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Aliases for SLC13A1 Gene

Aliases for SLC13A1 Gene

  • Solute Carrier Family 13 Member 1 2 3
  • Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 1 2 3 5
  • Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 1 2 3
  • Renal Sodium/Sulfate Cotransporter 3 4
  • Na(+)/Sulfate Cotransporter 3 4
  • HNaSi-1 3 4
  • NAS1 3 4
  • Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 1 3
  • NaSi-1 3
  • NASI1 4

External Ids for SLC13A1 Gene

Previous GeneCards Identifiers for SLC13A1 Gene

  • GC07M121231
  • GC07M122294
  • GC07M122308
  • GC07M122347
  • GC07M122540
  • GC07M122753
  • GC07M117116

Summaries for SLC13A1 Gene

GeneCards Summary for SLC13A1 Gene

SLC13A1 (Solute Carrier Family 13 Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transporter activity and sodium:sulfate symporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot for SLC13A1 Gene

  • Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A1 Gene

Genomics for SLC13A1 Gene

Regulatory Elements for SLC13A1 Gene

Enhancers for SLC13A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC13A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC13A1 Gene

Chromosome:
7
Start:
123,113,531 bp from pter
End:
123,199,986 bp from pter
Size:
86,456 bases
Orientation:
Minus strand

Genomic View for SLC13A1 Gene

Genes around SLC13A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC13A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC13A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A1 Gene

Proteins for SLC13A1 Gene

  • Protein details for SLC13A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW2-S13A1_HUMAN
    Recommended name:
    Solute carrier family 13 member 1
    Protein Accession:
    Q9BZW2
    Secondary Accessions:
    • Q9H5Z0

    Protein attributes for SLC13A1 Gene

    Size:
    595 amino acids
    Molecular mass:
    66134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC13A1 Gene

Proteomics data for SLC13A1 Gene at MOPED

Post-translational modifications for SLC13A1 Gene

  • Glycosylation at Asn 174, Asn 207, and Asn 591
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC13A1 Gene

No data available for DME Specific Peptides for SLC13A1 Gene

Domains & Families for SLC13A1 Gene

Gene Families for SLC13A1 Gene

Protein Domains for SLC13A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZW2

UniProtKB/Swiss-Prot:

S13A1_HUMAN :
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A1: view

Function for SLC13A1 Gene

Molecular function for SLC13A1 Gene

UniProtKB/Swiss-Prot Function:
Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney.
UniProtKB/Swiss-Prot Induction:
Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate.
genes like me logo Genes that share phenotypes with SLC13A1: view

Animal Models for SLC13A1 Gene

MGI Knock Outs for SLC13A1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC13A1 Gene

Localization for SLC13A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A1 Gene COMPARTMENTS Subcellular localization image for SLC13A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC13A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC13A1: view

Pathways & Interactions for SLC13A1 Gene

genes like me logo Genes that share pathways with SLC13A1: view

Interacting Proteins for SLC13A1 Gene

Gene Ontology (GO) - Biological Process for SLC13A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902358 sulfate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC13A1: view

No data available for SIGNOR curated interactions for SLC13A1 Gene

Drugs & Compounds for SLC13A1 Gene

(3) Drugs for SLC13A1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0

(5) Additional Compounds for SLC13A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC13A1: view

Transcripts for SLC13A1 Gene

Unigene Clusters for SLC13A1 Gene

Solute carrier family 13 (sodium/sulfate symporters), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A1 Gene

No ASD Table

Relevant External Links for SLC13A1 Gene

GeneLoc Exon Structure for
SLC13A1
ECgene alternative splicing isoforms for
SLC13A1

Expression for SLC13A1 Gene

mRNA expression in normal human tissues for SLC13A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A1 Gene

This gene is overexpressed in Kidney - Cortex (x34.3) and Small Intestine - Terminal Ileum (x16.1).

SOURCE GeneReport for Unigene cluster for SLC13A1 Gene Hs.489849

mRNA Expression by UniProt/SwissProt for SLC13A1 Gene

Q9BZW2-S13A1_HUMAN
Tissue specificity: Highly expressed in kidney; not detectable in the other tissues tested.
genes like me logo Genes that share expression patterns with SLC13A1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC13A1 Gene

Orthologs for SLC13A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC13A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC13A1 35
  • 87.79 (n)
  • 88.24 (a)
SLC13A1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A1 35
  • 85.43 (n)
  • 87.39 (a)
SLC13A1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a1 35
  • 83.67 (n)
  • 81.14 (a)
Slc13a1 16
Slc13a1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC13A1 35
  • 99.33 (n)
  • 98.66 (a)
SLC13A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a1 35
  • 83.98 (n)
  • 82.86 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC13A1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC13A1 35
  • 73.12 (n)
  • 73.85 (a)
SLC13A1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc13a1 35
  • 68.71 (n)
  • 69.97 (a)
Str.2252 35
zebrafish
(Danio rerio)
Actinopterygii slc13a1 35
  • 60.85 (n)
  • 58.46 (a)
slc13a1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Indy-2 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea B0285.6 37
  • 32 (a)
F31F6.6 37
  • 33 (a)
R107.1 37
  • 29 (a)
nac-1 36
  • 33 (a)
ManyToMany
nac-3 36
  • 33 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for SLC13A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A1 Gene

ENSEMBL:
Gene Tree for SLC13A1 (if available)
TreeFam:
Gene Tree for SLC13A1 (if available)

Paralogs for SLC13A1 Gene

Paralogs for SLC13A1 Gene

genes like me logo Genes that share paralogs with SLC13A1: view

Variants for SLC13A1 Gene

Sequence variations from dbSNP and Humsavar for SLC13A1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2140516 - 123,169,180(+) ATCCG(C/T)TGAAG reference, missense
rs28364181 - 123,181,077(-) CACTC(C/T)TTGTG reference, missense, utr-variant-5-prime
rs28364177 - 123,181,071(-) TTGTG(A/G)TCGCC reference, missense, utr-variant-5-prime
rs28364196 - 123,169,232(-) TGCAG(C/G)AGATC reference, missense
rs28364231 - 123,168,420(-) CAGAT(A/G)CAATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC13A1 Gene

Variant ID Type Subtype PubMed ID
nsv524192 CNV Gain 19592680
esv2735094 CNV Deletion 23290073
nsv520314 CNV Gain 19592680
esv34917 CNV Gain 17911159
dgv2134e1 CNV Complex 17122850
nsv818551 CNV Gain 17921354
nsv889123 CNV Loss 21882294

Variation tolerance for SLC13A1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC13A1 Gene

Human Gene Mutation Database (HGMD)
SLC13A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC13A1 Gene

Disorders for SLC13A1 Gene

Relevant External Links for SLC13A1

Genetic Association Database (GAD)
SLC13A1
Human Genome Epidemiology (HuGE) Navigator
SLC13A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC13A1

No disorders were found for SLC13A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC13A1 Gene

Publications for SLC13A1 Gene

  1. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. (PMID: 11161786) Lee A. … Markovich D. (Genomics 2000) 2 3 4 23 25 26 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. (PMID: 12857732) Li H. … Pajor A.M. (J. Biol. Chem. 2003) 3 23
  5. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. (PMID: 12867358) Li H. … Pajor A.M. (Am. J. Physiol., Cell Physiol. 2003) 3 23

Products for SLC13A1 Gene

Sources for SLC13A1 Gene

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