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Aliases for SLC13A1 Gene

Aliases for SLC13A1 Gene

  • Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 1 2 3
  • NAS1 3 4 6
  • Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 1 2 3
  • Renal Sodium/Sulfate Cotransporter 3 4
  • Na(+)/Sulfate Cotransporter 3 4
  • HNaSi-1 3 4
  • Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 1 3
  • Solute Carrier Family 13 Member 1 3
  • NaSi-1 3
  • NASI1 4

External Ids for SLC13A1 Gene

Previous GeneCards Identifiers for SLC13A1 Gene

  • GC07M121231
  • GC07M122294
  • GC07M122308
  • GC07M122347
  • GC07M122540
  • GC07M122753
  • GC07M117116

Summaries for SLC13A1 Gene

GeneCards Summary for SLC13A1 Gene

SLC13A1 (Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 1) is a Protein Coding gene. Diseases associated with SLC13A1 include primary hyperoxaluria. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include sodium:sulfate symporter activity. An important paralog of this gene is SLC13A4.

UniProtKB/Swiss-Prot for SLC13A1 Gene

  • Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A1 Gene

Genomics for SLC13A1 Gene

Regulatory Elements for SLC13A1 Gene

Genomic Location for SLC13A1 Gene

Start:
123,113,531 bp from pter
End:
123,199,986 bp from pter
Size:
86,456 bases
Orientation:
Minus strand

Genomic View for SLC13A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC13A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A1 Gene

Proteins for SLC13A1 Gene

  • Protein details for SLC13A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW2-S13A1_HUMAN
    Recommended name:
    Solute carrier family 13 member 1
    Protein Accession:
    Q9BZW2
    Secondary Accessions:
    • Q9H5Z0

    Protein attributes for SLC13A1 Gene

    Size:
    595 amino acids
    Molecular mass:
    66134 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC13A1 Gene

Proteomics data for SLC13A1 Gene at MOPED

Post-translational modifications for SLC13A1 Gene

  • Glycosylation at Asn174, Asn207, and Asn591
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC13A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC13A1 Gene

Domains for SLC13A1 Gene

Protein Domains for SLC13A1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BZW2

UniProtKB/Swiss-Prot:

S13A1_HUMAN :
  • Q9BZW2
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A1: view

Function for SLC13A1 Gene

Molecular function for SLC13A1 Gene

UniProtKB/Swiss-Prot Function: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney
UniProtKB/Swiss-Prot Induction: Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate

Gene Ontology (GO) - Molecular Function for SLC13A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0008271 secondary active sulfate transmembrane transporter activity --
GO:0015382 sodium:sulfate symporter activity IEA --
genes like me logo Genes that share ontologies with SLC13A1: view
genes like me logo Genes that share phenotypes with SLC13A1: view

Animal Models for SLC13A1 Gene

MGI Knock Outs for SLC13A1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC13A1 Gene

Localization for SLC13A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC13A1 Gene COMPARTMENTS Subcellular localization image for SLC13A1 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC13A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC13A1: view

Pathways for SLC13A1 Gene

genes like me logo Genes that share pathways with SLC13A1: view

Interacting Proteins for SLC13A1 Gene

Gene Ontology (GO) - Biological Process for SLC13A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport --
GO:0008272 sulfate transport --
GO:0035725 sodium ion transmembrane transport IEA --
GO:0055085 transmembrane transport TAS --
GO:1902358 sulfate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC13A1: view

Compounds for SLC13A1 Gene

(1) HMDB Compounds for SLC13A1 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC13A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Succinic acid
  • 1,2-Ethanedicarboxylic acid
110-15-6 target

(6) Novoseek inferred chemical compound relationships for SLC13A1 Gene

Compound -log(P) Hits PubMed IDs
nadc 86.5 2
dicarboxylate 78.5 3
sulfate 76.8 15
citrate 48.8 1
succinate 42.7 1
genes like me logo Genes that share compounds with SLC13A1: view

Transcripts for SLC13A1 Gene

mRNA/cDNA for SLC13A1 Gene

Unigene Clusters for SLC13A1 Gene

Solute carrier family 13 (sodium/sulfate symporters), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A1 Gene

No ASD Table

Relevant External Links for SLC13A1 Gene

GeneLoc Exon Structure for
SLC13A1
ECgene alternative splicing isoforms for
SLC13A1

Expression for SLC13A1 Gene

mRNA expression in normal human tissues for SLC13A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A1 Gene

This gene is overexpressed in Kidney - Cortex (34.3) and Small Intestine - Terminal Ileum (16.1).

SOURCE GeneReport for Unigene cluster for SLC13A1 Gene Hs.489849

mRNA Expression by UniProt/SwissProt for SLC13A1 Gene

Q9BZW2-S13A1_HUMAN
Tissue specificity: Highly expressed in kidney; not detectable in the other tissues tested
genes like me logo Genes that share expressions with SLC13A1: view

No data available for Protein expression for SLC13A1 Gene

Orthologs for SLC13A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC13A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC13A1 35
  • 99.33 (n)
  • 98.66 (a)
SLC13A1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC13A1 35
  • 87.79 (n)
  • 88.24 (a)
SLC13A1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC13A1 35
  • 85.43 (n)
  • 87.39 (a)
SLC13A1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc13a1 35
  • 83.67 (n)
  • 81.14 (a)
Slc13a1 16
Slc13a1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC13A1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A1 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc13a1 35
  • 83.98 (n)
  • 82.86 (a)
chicken
(Gallus gallus)
Aves SLC13A1 35
  • 73.12 (n)
  • 73.85 (a)
SLC13A1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC13A1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc13a1 35
  • 68.71 (n)
  • 69.97 (a)
Str.2252 35
zebrafish
(Danio rerio)
Actinopterygii slc13a1 35
  • 60.85 (n)
  • 58.46 (a)
slc13a1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Indy-2 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nac-1 36
  • 33 (a)
ManyToMany
nac-3 36
  • 33 (a)
ManyToMany
R107.1 37
  • 29 (a)
B0285.6 37
  • 32 (a)
F31F6.6 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
Species with no ortholog for SLC13A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A1 Gene

ENSEMBL:
Gene Tree for SLC13A1 (if available)
TreeFam:
Gene Tree for SLC13A1 (if available)

Paralogs for SLC13A1 Gene

Paralogs for SLC13A1 Gene

genes like me logo Genes that share paralogs with SLC13A1: view

Variants for SLC13A1 Gene

Sequence variations from dbSNP and Humsavar for SLC13A1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1064464 -- 123,164,619(-) aacct(A/G)aaatg intron-variant
rs1141626 -- 123,164,653(-) tacct(A/G)tataa intron-variant
rs1317626 -- 123,131,301(+) TAATG(C/T)GCCAC intron-variant
rs1320393 -- 123,131,653(-) CAGCC(A/G)CTCCC intron-variant
rs1343903 -- 123,167,309(+) TATCT(C/T)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC13A1 Gene

Variant ID Type Subtype PubMed ID
nsv524192 CNV Gain 19592680
esv2735094 CNV Deletion 23290073
nsv520314 CNV Gain 19592680
esv34917 CNV Gain 17911159
dgv2134e1 CNV Complex 17122850
nsv818551 CNV Gain 17921354
nsv889123 CNV Loss 21882294

Relevant External Links for SLC13A1 Gene

HapMap Linkage Disequilibrium report
SLC13A1
Human Gene Mutation Database (HGMD)
SLC13A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC13A1 Gene

Disorders for SLC13A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC13A1 Gene including...

Search for SLC13A1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SLC13A1 Gene

(1) Novoseek inferred disease relationships for SLC13A1 Gene

Disease -log(P) Hits PubMed IDs
intoxication 32.4 2

Relevant External Links for SLC13A1

Genetic Association Database (GAD)
SLC13A1
Human Genome Epidemiology (HuGE) Navigator
SLC13A1
genes like me logo Genes that share disorders with SLC13A1: view

No data available for UniProtKB/Swiss-Prot for SLC13A1 Gene

Publications for SLC13A1 Gene

  1. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. (PMID: 11161786) Lee A. … Markovich D. (Genomics 2000) 2 3 4 23 25
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48
  4. Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma. (PMID: 20670164) Horinouchi M. … Nakamura T. (Pediatr Hematol Oncol 2010) 3 48
  5. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. (PMID: 12857732) Li H. … Pajor A.M. (J. Biol. Chem. 2003) 3 23

Products for SLC13A1 Gene

Sources for SLC13A1 Gene

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