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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC13A1 Gene

protein-coding   GIFtS: 56
GCID: GC07M122753

Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member...

(Previous names: solute carrier family 13 (sodium/sulphate symporters), member...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 11 2     Na(+)/Sulfate Cotransporter2 3
NAS12 3 5     NaSi-12
Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 11 2     Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 12
Renal Sodium/Sulfate Cotransporter2 3     Solute Carrier Family 13 Member 12
hNaSi-12 3     NASI13

External Ids:    HGNC: 109161   Entrez Gene: 65612   Ensembl: ENSG000000818007   OMIM: 6061935   UniProtKB: Q9BZW23   

Export aliases for SLC13A1 gene to outside databases

Previous GC identifers: GC07M121231 GC07M122294 GC07M122308 GC07M122347 GC07M122540 GC07M117116


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC13A1 Gene: 
SLC13A1 (solute carrier family 13 (sodium/sulfate symporter), member 1) is a protein-coding gene. Diseases associated with SLC13A1 include diastrophic dysplasia, and primary hyperoxaluria, and among its related super-pathways are Transmembrane transport of small molecules and Sodium-coupled sulphate, di- and tri-carboxylate transporters. GO annotations related to this gene include sodium:sulfate symporter activity. An important paralog of this gene is SLC13A5.

UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
Function: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC13A1 gene promoter:
         Nkx3-1   Nkx3-1 v4   USF1   IRF-1   Nkx3-1 v1   Nkx2-5   C/EBPalpha   Nkx3-1 v2   USF-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC13A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC13A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC13A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.32   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.32

SLC13A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC13A1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M122753:  view genomic region     (about GC identifiers)

Start:
122,753,585 bp from pter      End:
122,840,040 bp from pter
Size:
86,456 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 122,142,198-122,228,657     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2 (See protein sequence)
Recommended Name: Solute carrier family 13 member 1  
Size: 595 amino acids; 66134 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9H5Z0

Explore the universe of human proteins at neXtProt for SLC13A1: NX_Q9BZW2

Explore proteomics data for SLC13A1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZW2

  • SLC13A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC13A1 Protein Expression
    REFSEQ proteins: NP_071889.2  
    ENSEMBL proteins: 
     ENSP00000194130   ENSP00000388403   ENSP00000401417   ENSP00000441309  
    Reactome Protein details: Q9BZW2
    Human Recombinant Protein Products for SLC13A1: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC13A1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC13A1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for SLC13A1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Na+/sulfate cotransporter 
    SLC13 family of sodium-dependent sulphate/carboxylate transporters

    1 InterPro protein domain:
     IPR001898 Na/sul_symport

    Graphical View of Domain Structure for InterPro Entry Q9BZW2

    ProtoNet protein and cluster: Q9BZW2

    1 Blocks protein domain: IPB001898 Sodium/sulphate symporter

    UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
    Similarity: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily


    SLC13A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S13A1_HUMAN, Q9BZW2
    Function: Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney
    Induction: Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity ----
    GO:0008271secondary active sulfate transmembrane transporter activity ----
    GO:0015382sodium:sulfate symporter activity IEA--
         
    SLC13A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC13A1:
     Increased cell number in G2M,  

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc13a1):
     behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism  limbs/digits/tail 
     liver/biliary system  nervous system  renal/urinary system  reproductive system  skeleton 

    SLC13A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc13a1tm1Mark for SLC13A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC13A1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC13A1 
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    miRNA
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    hsa-miR-4291 hsa-miR-656 hsa-miR-633 hsa-miR-380 hsa-miR-944 hsa-miR-664 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidSLC13A1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC13A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Bile salt and organic anion SLC transporters
    Bile salt and organic anion SLC transporters0.42
    Sodium-coupled sulphate, di- and tri-carboxylate transporters0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5        Reactome Pathways for SLC13A1
        Sodium-coupled sulphate, di- and tri-carboxylate transporters
    Bile salt and organic anion SLC transporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds



    SLC13A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC13A1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport ----
    GO:0008272sulfate transport IEA--
    GO:0055085transmembrane transport TAS--

    SLC13A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC13A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC13A1 (S13A1)

    1 HMDB Compound for SLC13A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for SLC13A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Succinic acid1,2-Ethanedicarboxylic acid (see all 8)110-15-6target--11161786 17139284 17016423

    6 Novoseek inferred chemical compound relationships for SLC13A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadc 86.5 2 12867358 (1), 12857732 (1)
    dicarboxylate 78.5 3 12857732 (1), 10535998 (1), 9518567 (1)
    sulfate 76.8 17 11231338 (3), 11161786 (2), 10998198 (2), 9486223 (1) (see all 11)
    citrate 48.8 1 11161786 (1)
    succinate 42.7 1 11161786 (1)
    vitamin d 29.2 3 15197597 (2), 11231338 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC13A1 / S13A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC13A1 gene: 
    NM_022444.3  

    Unigene Cluster for SLC13A1:

    Solute carrier family 13 (sodium/sulfate symporters), member 1
    Hs.489849  [show with all ESTs]
    Unigene Representative Sequence: AF260824
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000194130(uc003vkm.3 uc010lks.3) ENST00000427975 ENST00000439260
    ENST00000539873
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC13A1:
    hsa-miR-4291 hsa-miR-656 hsa-miR-633 hsa-miR-380 hsa-miR-944 hsa-miR-664 hsa-miR-493
    SwitchGear 3'UTR luciferase reporter plasmidSLC13A1 3' UTR sequence
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    Additional mRNA sequence: 

    AF260824.1 AK026413.1 AK314537.1 BC111775.1 

    3 DOTS entries:

    DT.204482  DT.121105243  DT.40304031 

    18 AceView cDNA sequences:

    NM_022444 AI015652 AI732845 AI469201 AI733589 AA858019 BG054487 AF260824 
    AI491922 AI792169 BX104566 BG400459 BG433404 BP382927 AK026413 BG430415 
    BG428081 AW236701 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC13A1 expression in normal human tissues (normalized intensities)      SLC13A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCATTTT
    SLC13A1 Expression
    About this image


    SLC13A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             ganglion/cranial   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Thoracic Rib
             skeleton/cranium/viscerocranium   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             skeleton/cranium/viscerocranium   

    See SLC13A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC13A1

    SOURCE GeneReport for Unigene cluster: Hs.489849

    UniProtKB/Swiss-Prot: S13A1_HUMAN, Q9BZW2
    Tissue specificity: Highly expressed in kidney; not detectable in the other tissues tested

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC13A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC13A1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc13a11 , 5 solute carrier family 13 (sodium/sulfate symporters), more1, 5 83.67(n)1
    81.14(a)1
      6 (11.22 cM)5
    559611  NM_019481.21  NP_062354.21 
     240882835 
    chicken
    (Gallus gallus)
    Aves SLC13A11 solute carrier family 13 (sodium/sulfate symporters), more 73.9(n)
    75.44(a)
      770198  XM_001233530.2  XP_001233531.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC13A16
    Uncharacterized protein
    74(a)
    1 ↔ 1
    5(67706435-67764512)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.22522 Transcribed sequence with weak similarity to protein more 71.72(n)    142032759 
    zebrafish
    (Danio rerio)
    Actinopterygii slc13a12 solute carrier family 13 (sodium/sulphate symporters), more 74.72(n)   387592  BC058313.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Indy6
    CG339346
    (see all 4)
    --
    31(a)
    31(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    3L(18821732-18839367)
    3R(15868479-15874438)
    worm
    (Caenorhabditis elegans)
    Secernentea F31F6.63 Na+/sulphate co-transporter like 33(a)
    (best of 3)
      X(14930379-14933500)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHO916
    PHO906
    (see all 3)
    Low-affinity phosphate transporter of the vacuolar...
    Low-affinity phosphate transporter; deletion of ph...
    (see all 3)
    11(a)
    11(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    XIV(649028-651712)
    X(60844-63489)


    ENSEMBL Gene Tree for SLC13A1 (if available)
    TreeFam Gene Tree for SLC13A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC13A1 gene
    SLC13A52  SLC13A42  SLC13A22  SLC13A32  
    5 SIMAP similar genes for SLC13A1 using alignment to 8 protein entries:     S13A1_HUMAN (see all proteins):
    SLC13A4    SLC13A3    SLC13A5    DKFZp686E17257    SLC13A2

    SLC13A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1756 SNPs in SLC13A1 are shown (see all 1756)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127064851,2
    C,F,H--122753122(+) CATGAA/GCAGAC 1 -- ds500119Minor allele frequency- G:0.20NS EA NA WA 2344
    rs102519631,2
    C,F--122753178(+) TCCAAT/CCCTAA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs102467951,2
    C,F--122753338(+) ACAGTA/TTGCAA 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1816992901,2
    --122753380(+) TGTAAA/GTGGGA 1 -- ds50010--------
    rs1513103291,2
    --122753508(+) GCTAGA/CAGCTA 1 -- ds50010--------
    rs1151405511,2
    C,F--122753641(+) TCTGAT/GGCAAT 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1864888421,2
    C--122753741(+) AGGAAC/TAAATG 1 -- ut310--------
    rs765241101,2
    C--122753766(+) AGAAGA/TGTTAT 1 -- ut310--------
    rs1133159501,2
    F--122753962(+) TAATCG/TTATTT 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs126736691,2
    C,A,H--122754046(+) GGCAGG/CAGAAT 1 -- ut31 ese35Minor allele frequency- C:0.29NA EA 246

    HapMap Linkage Disequilibrium report for SLC13A1 (122753585 - 122840040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SLC13A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2735094CNV Deletion23290073
    nsv889123CNV Loss21882294
    nsv520314CNV Gain19592680
    nsv524192CNV Gain19592680
    esv34917CNV Gain17911159
    nsv818551CNV Gain17921354
    dgv2134e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606193    OMIM disorders: --

    9 diseases for SLC13A1:    About MalaCards
    diastrophic dysplasia    primary hyperoxaluria    nephrolithiasis    hypothyroidism
    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia    endotheliitis
    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for SLC13A1:
    Primary hyperoxaluria     Nephrolithiasis

    SLC13A1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC13A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intoxication 32.4 2 9486223 (1), 11231338 (1)

    Genetic Association Database (GAD): SLC13A1
    Human Genome Epidemiology (HuGE) Navigator: SLC13A1 (3 documents)

    Export disorders for SLC13A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC13A1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SLC13A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. (PubMed id 11161786)1, 2, 3, 7, 9 Lee A.... Markovich D. (2000)
    2. Association of genetic polymorphisms with hepatotoxic ity in patients with childhood acute lymphoblastic leukemia or lymphoma. (PubMed id 20670164)1, 4 Horinouchi M....Nakamura T. (2010)
    3. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (2009)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity. (PubMed id 12867358)1, 9 Li H. and Pajor A.M. (2003)
    6. Serines 260 and 288 are involved in sulfate transport by hNaSi-1. (PubMed id 12857732)1, 9 Li H. and Pajor A.M. (2003)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    8. Genome-wide association with diabetes-related traits in the Framingham Heart Study. (PubMed id 17903298)4 Meigs J.B....Dupuis J. (2007)
    9. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (PubMed id 17463248)4 Scott L.J....Boehnke M. (2007)
    10. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6561 HGNC: 10916 AceView: SLC13A1 Ensembl:ENSG00000081800 euGenes: HUgn6561
    ECgene: SLC13A1 H-InvDB: SLC13A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC13A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC13A1 gene:
    Search GeneIP for patents involving SLC13A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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