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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC12A9 Gene

protein-coding   GIFtS: 49
GCID: GC07P100424

Solute Carrier Family 12, Member 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 12, Member 91 2     CCC-Interacting Protein 12 3
Cation-Chloride Cotransporter 62 3     hCCC62 3
Cation-Chloride Cotransporter-Interacting Protein 12 3     Cation-Chloride Cotransporter-Interacting Protein1
Potassium-Chloride Transporter 92 3     Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 92
CCC62 3     Solute Carrier Family 12 Member 92
CIP12 3     hCIP13
WO3.32 3     

External Ids:    HGNC: 174351   Entrez Gene: 569962   Ensembl: ENSG000001468287   UniProtKB: Q9BXP23   

Export aliases for SLC12A9 gene to outside databases

Previous GC identifers: GC07P100047 GC07P100061 GC07P100095 GC07P100290 GC07P095080


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC12A9 Gene: 
SLC12A9 (solute carrier family 12, member 9) is a protein-coding gene. Diseases associated with SLC12A9 include gitelman syndrome, and resting heart rate. GO annotations related to this gene include cation:chloride symporter activity. An important paralog of this gene is SLC12A7.

UniProtKB/Swiss-Prot: S12A9_HUMAN, Q9BXP2
Function: May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and
thus, additional subunits may be required for its function

Gene Wiki entry for SLC12A9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC12A9 gene promoter:
         c-Fos   STAT1   p53   AP-1   c-Jun   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): SLC12A9 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC12A9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC12A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

SLC12A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC12A9 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100424:  view genomic region     (about GC identifiers)

Start:
100,424,442 bp from pter      End:
100,464,634 bp from pter
Size:
40,193 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,809,963-99,824,239     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S12A9_HUMAN, Q9BXP2 (See protein sequence)
Recommended Name: Solute carrier family 12 member 9  
Size: 914 amino acids; 96110 Da
Subunit: Interacts with SLC12A1
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B7Z740 D6W5X0 D6W5X2 F5H8C2 Q9BWL2 Q9BXP1 Q9BYI0 Q9NQR5
Alternative splicing: 4 isoforms:  Q9BXP2-1   Q9BXP2-2   Q9BXP2-3   Q9BXP2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC12A9: NX_Q9BXP2

Explore proteomics data for SLC12A9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXP2

  • SLC12A9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC12A9 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001254741.1  NP_001254743.1  NP_064631.2  

    ENSEMBL proteins: 
     ENSP00000401583   ENSP00000406560   ENSP00000413796   ENSP00000275730   ENSP00000410692  
     ENSP00000408571   ENSP00000408301   ENSP00000275729   ENSP00000443702  

    Human Recombinant Protein Products for SLC12A9: 
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    Novus Biologicals SLC12A9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC12A9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cation-chloride cotransporter 6 
    SLC12 family of cation-coupled chloride transporters

    1 InterPro protein domain:
     IPR004841 AA-permease_dom

    Graphical View of Domain Structure for InterPro Entry Q9BXP2

    ProtoNet protein and cluster: Q9BXP2

    UniProtKB/Swiss-Prot: S12A9_HUMAN, Q9BXP2
    Similarity: Belongs to the SLC12A transporter family


    SLC12A9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S12A9_HUMAN, Q9BXP2
    Function: May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and
    thus, additional subunits may be required for its function

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015377cation:chloride symporter activity TAS10871601
         
    SLC12A9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC12A9:
     Synthetic lethal with c-Myc af 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC12A9 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLC12A9 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC12A9

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/23 Interacting proteins for SLC12A9 (Q9BXP23 ENSP000002757304) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF4O956393, ENSP000002924764I2D: score=1 STRING: ENSP00000292476
    ATAD2Q6PL183I2D: score=1 
    ATP6V0A1Q930503I2D: score=1 
    DIAPH1O606103I2D: score=1 
    ELP3Q9H9T33I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0055085transmembrane transport ----

    SLC12A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC12A9 (S12A9)

    Search CenterWatch for drugs/clinical trials and news about SLC12A9 / S12A9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC12A9 gene (3 alternative transcripts): 
    NM_001267812.1  NM_001267814.1  NM_020246.3  

    Unigene Cluster for SLC12A9:

    Solute carrier family 12 (potassium/chloride transporters), member 9
    Hs.521087  [show with all ESTs]
    Unigene Representative Sequence: NM_020246
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461016 ENST00000448342 ENST00000418037 ENST00000415287(uc003uwq.3)
    ENST00000462106 ENST00000354161(uc003uwp.3) ENST00000416675 ENST00000434158
    ENST00000475687(uc003uwr.3) ENST00000467972(uc003uwt.3) ENST00000497958
    ENST00000487651(uc011kki.2 uc003uwv.3) ENST00000475623 ENST00000482184
    ENST00000428758 ENST00000275729(uc003uwo.1) ENST00000540482
    miRNA
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    hsa-miR-142-3p hsa-miR-2052 hsa-miR-4291 hsa-miR-19b-2* hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidSLC12A9 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC12A9

    Additional mRNA sequence: 

    AB033284.1 AF284422.1 AK026624.1 AK128873.1 AK301411.1 BC000154.2 

    15 DOTS entries:

    DT.112471  DT.100779176  DT.97799872  DT.97844443  DT.100779170  DT.121068883  DT.100686167  DT.100779168 
    DT.100701485  DT.102843084  DT.75138336  DT.100686386  DT.121068827  DT.121068881  DT.121068951 

    24/142 AceView cDNA sequences (see all 142):

    CA943814 AI831378 AW574997 AI627244 BU431433 AW005000 AA427782 AI499636 
    AI208223 AI540616 BM769085 BU149251 AI302617 AI089415 AA825567 NM_020246 
    AK024494 AK026624 AW778976 BM768674 BU608808 AA917606 CA976065 AI654384 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SLC12A9 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
    SP1:                                -                             -     -                       -                             -     -                           
    SP2:                                -           -     -     -     -     -                       -                             -     -                           
    SP3:                                                                                            -           -                                                   
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -     -                       -                             -     -                           

    ExUns: 15 ^ 16 ^ 17
    SP1:        -         
    SP2:                  
    SP3:        -         
    SP4:        -         
    SP5:                  


    ECgene alternative splicing isoforms for SLC12A9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC12A9 expression in normal human tissues (normalized intensities)      SLC12A9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAGAC
    SLC12A9 Expression
    About this image


    SLC12A9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             neutrophils   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See SLC12A9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC12A9

    SOURCE GeneReport for Unigene cluster: Hs.521087

    UniProtKB/Swiss-Prot: S12A9_HUMAN, Q9BXP2
    Tissue specificity: Highly expressed in placenta, brain and kidney. Lower expression in lung, liver and heart

        SABiosciences Custom PCR Arrays for SLC12A9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC12A9 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc12a91 , 5 solute carrier family 12 (potassium/chloride transporters), more1, 5 85.54(n)1
    93.54(a)1
      5 (76.35 cM)5
    837041  NM_031406.31  NP_113583.21 
     1373145585 
    chicken
    (Gallus gallus)
    Aves SLC12A91 solute carrier family 12 (potassium/chloride transporters), more 65.37(n)
    60.94(a)
      424938  XM_003641791.1  XP_003641839.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC12A96
    --
    Uncharacterized protein
    69(a)
    51(a)
    1 ↔ 1
    possible ortholog
    GL343939.1(104795-120788)
    GL343304.1(331266-504794)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX773985.12   -- 75.11(n)    BX773985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc12a91 solute carrier family 12 (potassium/chloride transporters), more 61.7(n)
    60.91(a)
      793341  NM_001128548.1  NP_001122020.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG104131 CG10413 51.43(n)
    46.19(a)
      35111  NM_136043.2  NP_609887.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T04B8.51 Protein T04B8.5 48.55(n)
    42.89(a)
      173453  NM_001027134.2  NP_001022305.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YBR235W)4
    YBR235W1
    Putative ion transporter, similar to mammalian electroneutral more4
    hypothetical protein1
    42.04(n)1
    36.16(a)1
      2(686901-690263)4
    8525371, 4  NP_009794.31  NP_009794.14 


    ENSEMBL Gene Tree for SLC12A9 (if available)
    TreeFam Gene Tree for SLC12A9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC12A9 gene
    SLC12A72  SLC12A82  SLC12A12  SLC12A42  SLC12A52  SLC12A32  SLC12A22  SLC12A62  
    10 SIMAP similar genes for SLC12A9 using alignment to 7 protein entries:     S12A9_HUMAN (see all proteins):
    FLJ00009    FLJ00059    FLJ00100    FLJ00379    FLJ00010    SLC12A6
    SLC12A5    SLC12A8    SLC12A4    SLC12A3

    SLC12A9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/457 SNPs in SLC12A9 are shown (see all 457)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105985731,2
    C--100461719(+) ttttt-/T/TT  
            
    ggaca
    3 -- int11NA 2
    rs1823997811,2
    --103754318(+) GTTTTC/GCTCTT 3 -- us2k10--------
    rs1873973321,2
    --103754374(+) CCTCCA/GCCTCC 3 -- us2k10--------
    rs1906861961,2
    --103754380(+) CCTCCC/TGTGTT 3 -- us2k10--------
    rs3143681,2
    C,A--103754391(-) agaatC/Agcttg 3 -- us2k13Minor allele frequency- A:0.17NA CSA 6
    rs1407960621,2
    --103754422(+) AGCTGA/GGATTA 3 -- us2k10--------
    rs1828585771,2
    --103754828(+) AAGAGG/TTGAAC 3 -- us2k10--------
    rs1500790601,2
    C--103754850(+) GGCTGC/GAGTCA 3 -- us2k10--------
    rs1434020301,2
    C--103754972(+) GCTTA-/TAAC  
            
    TAACT
    3 -- us2k10--------
    rs624824611,2
    C,F--103755043(+) CTGGAG/ATGCAG 3 -- us2k12Minor allele frequency- A:0.05NA 122

    HapMap Linkage Disequilibrium report for SLC12A9 (100424442 - 100464634 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC12A9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv5870CNV Insertion18451855
    dgv7403n71CNV Loss21882294
    nsv831073CNV Loss17160897
    dgv7402n71CNV Loss21882294
    dgv2119e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for SLC12A9:    About MalaCards
    gitelman syndrome    resting heart rate    lipoma

    1 disease from the University of Copenhagen DISEASES database for SLC12A9:
    Gitelman syndrome

    SLC12A9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC12A9
    Human Genome Epidemiology (HuGE) Navigator: SLC12A9 (1 document)

    Export disorders for SLC12A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC12A9 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SLC12A9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2, 3 Wilson M.D....Koop B.F. (2001)
    2. Cloning and functional characterization of a cation-Cl-cotransporter- interacting protein. (PubMed id 10871601)1, 2, 3 Caron L.... Isenring P. (2000)
    3. Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)1, 4 Lettre G....Boerwinkle E. (2011)
    4. Genome-wide association analysis identifies multiple loci related to resting heart rate. (PubMed id 20639392)1, 4 Eijgelsheim M....O'Donnell C.J. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Physiology of SLC12 transporters: lessons from inherit ed human genetic mutations and genetically engineered mouse knockouts. (PubMed id 23325410)1 Gagnon K.B. and Delpire E. (2013)
    7. Genome-wide association study for circulating levels o f PAI-1 provides novel insights into its regulation. (PubMed id 22990020)1 Huang J....Hamsten A. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56996 HGNC: 17435 AceView: SLC12A9 Ensembl:ENSG00000146828 euGenes: HUgn56996
    ECgene: SLC12A9 H-InvDB: SLC12A9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC12A9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC12A9 gene:
    Search GeneIP for patents involving SLC12A9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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