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SLC12A8 Gene

protein-coding   GIFtS: 49
GCID: GC03M124801

Solute Carrier Family 12, Member 8

  See SLC12A8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 12, Member 81 2     Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporters)1
Cation-Chloride Cotransporter 91 2 3     Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 82
CCC92 3     Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporters), Member
82
Member 81     Solute Carrier Family 12 Member 82

External Ids:    HGNC: 155951   Entrez Gene: 845612   Ensembl: ENSG000002219557   OMIM: 6113165   UniProtKB: A0AV023   

Export aliases for SLC12A8 gene to outside databases

Previous GC identifers: GC03M121548 GC03M124832 GC03M126083 GC03M126122 GC03M126284 GC03M122175


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC12A8 Gene:
This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript
variants of this gene have been described, but the full-length nature of some of these variants has not been
determined. (provided by RefSeq, Sep 2010)

GeneCards Summary for SLC12A8 Gene:
SLC12A8 (solute carrier family 12, member 8) is a protein-coding gene. Diseases associated with SLC12A8 include gitelman syndrome, and psoriasis. GO annotations related to this gene include symporter activity. An important paralog of this gene is SLC12A7.

UniProtKB/Swiss-Prot: S12A8_HUMAN, A0AV02
Function: Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation

Gene Wiki entry for SLC12A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC12A8 gene promoter:
         CUTL1   Nkx2-5   E47   S8   POU2F1   Ik-2   HFH-1   Sox9   Ik-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC12A8 promoter sequence
   Search Chromatin IP Primers for SLC12A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC12A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

SLC12A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC12A8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M124801:  view genomic region     (about GC identifiers)

Start:
124,801,480 bp from pter      End:
124,998,021 bp from pter
Size:
196,542 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S12A8_HUMAN, A0AV02 (See protein sequence)
Recommended Name: Solute carrier family 12 member 8  
Size: 714 amino acids; 78223 Da
Sequence caution: Sequence=AAH20506.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH63528.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH63528.1;
Type=Frameshift; Positions=569; Sequence=AAK94307.1; Type=Erroneous gene model prediction; Sequence=AAM73657.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD97969.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JJJ2 Q68D04 Q6I9Z2 Q6P4C0 Q7Z3A6 Q86WK0 Q8NFX9 Q8WUI3 Q96RF9 Q9H5P9
Alternative splicing: 5 isoforms:  A0AV02-1   A0AV02-2   A0AV02-3   A0AV02-4   A0AV02-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC12A8: NX_A0AV02

Explore proteomics data for SLC12A8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn221
  • Modification sites at PhosphoSitePlus

  • See SLC12A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182412.1  NP_078904.3  

    ENSEMBL proteins: 
     ENSP00000415713   ENSP00000377112   ENSP00000419424   ENSP00000418783   ENSP00000420197  
     ENSP00000418636   ENSP00000404243   ENSP00000323632  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online peptides for SLC12A8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Cation-chloride cotransporter 9
    SLC12 family of cation-coupled chloride transporters

    1 InterPro protein domain:
     IPR004841 AA-permease/SLC12A_dom

    Graphical View of Domain Structure for InterPro Entry A0AV02

    ProtoNet protein and cluster: A0AV02

    UniProtKB/Swiss-Prot: S12A8_HUMAN, A0AV02
    Similarity: Belongs to the SLC12A transporter family


    Find genes that share domains with SLC12A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S12A8_HUMAN, A0AV02
    Function: Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding ----
    GO:0015293symporter activity IEA--
    GO:0042626ATPase activity, coupled to transmembrane movement of substances ----
         
    Find genes that share ontologies with SLC12A8           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc12a8):
     normal 

    Find genes that share phenotypes with SLC12A8           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC12A8

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S12A8_HUMAN, A0AV02: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus1
    vacuole1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC12A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC12A8
    Interactions:

        Search GeneGlobe Interaction Network for SLC12A8

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006813potassium ion transport IEA--
    GO:0055085transmembrane transport ----

    Find genes that share ontologies with SLC12A8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC12A8 (S12A8)

    1 HMDB Compound for SLC12A8    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC12A8 gene (2 alternative transcripts): 
    NM_001195483.1  NM_024628.5  

    Unigene Cluster for SLC12A8:

    Solute carrier family 12 (potassium/chloride transporters), member 8
    Hs.658514  [show with all ESTs]
    Unigene Representative Sequence: NM_024628
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430155(uc003eht.4 uc010hry.3) ENST00000393469(uc003ehv.4)
    ENST00000473262 ENST00000465475 ENST00000469902(uc010hrz.1) ENST00000479352
    ENST00000483944 ENST00000461616 ENST00000485954 ENST00000479231 ENST00000465777
    ENST00000495105 ENST00000485849 ENST00000479826 ENST00000462437 ENST00000481760
    ENST00000423114(uc003ehw.4) ENST00000314584
    miRNA
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    hsa-miR-509-5p hsa-miR-509-3-5p hsa-miR-105
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      QuantiFast Probe-based Assays in human, mouse, rat SLC12A8

    Additional mRNA sequence: 

    AF345197.1 AF390442.1 AK026841.1 AK123001.1 AK308484.1 BC020506.1 BC063528.1 BC126158.1 
    BC126160.1 BX538023.1 CR457363.1 

    9 DOTS entries:

    DT.310637  DT.97838644  DT.91883193  DT.101983324  DT.91904941  DT.100774290  DT.120909144  DT.92414678 
    DT.120909177 

    Selected AceView cDNA sequences (see all 314):

    BM665217 BM771821 AA399260 BF195807 AF039019 AI669012 CR596399 BM719799 
    BC018971 AA721431 BQ674550 AI735246 AA593021 AU133977 AA213408 BU739668 
    AI669304 AA084104 AA213407 AA325583 BQ686353 AA383189 BU178504 BU902868 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC12A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC12A8 Expression
    About this image


    SLC12A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
    SLC12A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC12A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658514

    UniProtKB/Swiss-Prot: S12A8_HUMAN, A0AV02
    Tissue specificity: Ubiquitous with very low level in normal skin

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC12A8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc12a81 , 5 solute carrier family 12 (potassium/chloride transporters), more1, 5 82.64(n)1
    81.4(a)1
      16 (24.12 cM)5
    1712861  NM_134251.21  NP_599012.21 
     335173285 
    chicken
    (Gallus gallus)
    Aves SLC12A81 solute carrier family 12 (potassium/chloride transporters), more 68.95(n)
    68.05(a)
      424258  XM_003641624.2  XP_003641672.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    72(a)
    56(a)
    1 ↔ many
    1 ↔ many
    AAWZ02037227(7465-15846)
    1(77957827-77992994)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.181552 Transcribed sequence with weak similarity to protein more 80.65(n)    AL956069.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi11e032 Transcribed sequence with weak similarity to protein more 73.25(n)    57063469 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG127731 CG12773 54.04(n)
    43.19(a)
      31082  NM_130549.3  NP_569905.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F10E7.91 F10E7.9 47.92(n)
    40.78(a)
      174167  NM_063068.4  NP_495469.2 


    ENSEMBL Gene Tree for SLC12A8 (if available)
    TreeFam Gene Tree for SLC12A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC12A8 gene
    SLC12A72  SLC12A32  SLC12A92  SLC12A62  SLC12A22  SLC12A12  SLC12A42  SLC12A52  
    6 SIMAP similar genes for SLC12A8 using alignment to 6 protein entries:     S12A8_HUMAN (see all proteins):
    SLC12A1    SLC12A9    SLC12A6    SLC12A3    SLC12A5    SLC12A4

    Find genes that share paralogs with SLC12A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC12A8 (see all 3050)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117145091,2
    C,F--124768579(+) TGCCCA/GCCATC 2 -- ds50012Minor allele frequency- G:0.33WA CSA 3
    rs1932668271,2
    C--124768651(+) GTCTCA/GAACTC 2 -- ds50010--------
    rs1854351931,2
    --124768678(+) CACCCA/GTCTCA 2 -- ds50010--------
    rs1446754551,2
    --124768711(+) CCGGCA/GTGAAC 2 -- ds50010--------
    rs1893704611,2
    C--124768782(+) TGATTA/CATGAG 2 -- ds50010--------
    rs1385683891,2
    C--124768840(+) CCTCCA/GTGGCT 2 -- ds50010--------
    rs20767281,2
    C,F--124768907(-) GGGCCG/ATGGCA 2 -- ds50017Minor allele frequency- A:0.23NA CSA WA EA 366
    rs1161186671,2
    F--124769008(+) AGCTGC/TGAAGG 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1817405481,2
    C--124769071(+) GGCAAA/C/TTCATG 4 -- ut310--------
    rs1860926501,2
    --124769234(+) GTCATC/TGCAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC12A8 (124801480 - 124998021 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC12A8 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675147CNV Deletion23128226
    esv2551779CNV Deletion19546169
    esv2119517CNV Deletion18987734
    esv2725853CNV Deletion23290073
    nsv3982CNV Insertion18451855
    esv1521223CNV Insertion17803354
    esv989274CNV Insertion20482838
    nsv511221CNV Loss21212237
    nsv523278CNV Loss19592680
    esv34126CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611316    OMIM disorders: --

    UniProtKB/Swiss-Prot: S12A8_HUMAN, A0AV02
  • Note=SLC12A8 has been identified as a possible susceptibility gene for psoriasis mapped to chromosome
    3q21 (PSORS5)

  • 2 diseases for SLC12A8:    
    About MalaCards
    gitelman syndrome    psoriasis

    1 disease from the University of Copenhagen DISEASES database for SLC12A8:
    Gitelman syndrome

    Find genes that share disorders with SLC12A8           About GenesLikeMe

    Genetic Association Database (GAD): SLC12A8
    Human Genome Epidemiology (HuGE) Navigator: SLC12A8 (2 documents)

    Export disorders for SLC12A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC12A8 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SLC12A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a psoriasis susceptibility candidate gene by linkage disequilibrium mapping with a localized single nucleotide polymorphism map. (PubMed id 11863360)1, 2, 3, 9 Hewett D.... Purvis I. (Genomics 2002)
    2. Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris. (PubMed id 16297188)1, 2, 4 Hueffmeier U.... Reis A. (J. Invest. Dermatol. 2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Molecular characterization of a human cation-Cl- cotransporter (SLC12A8A, CCC9A) that promotes polyamine and amino acid transport. (PubMed id 19472210)1, 9 Daigle N.D....Isenring P. (J. Cell. Physiol. 2009)
    5. Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts. (PubMed id 23325410)1 Gagnon K.B. and Delpire E. (Am. J. Physiol., Cell Physiol. 2013)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. (PubMed id 12739168)1 Hebert S.C....Gamba G. (Pflugers Arch. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84561 HGNC: 15595 AceView: ZNF148andSLC12A8 Ensembl:ENSG00000221955 euGenes: HUgn84561
    ECgene: SLC12A8 H-InvDB: SLC12A8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC12A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC12A8 gene:
    Search GeneIP for patents involving SLC12A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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