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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC12A7 Gene

protein-coding   GIFtS: 63
GCID: GC05M001050

solute carrier family 12 (potassium/chloride transporters),...
 Explore 7 diseases affiliated with
SLC12A7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC12A7    

Aliases
for SLC12A7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 71 2     DKFZP434F0761
KCC41 2 3 5     Potassium/Chloride Transporter KCC42
Electroneutral Potassium-Chloride Cotransporter 42 3     Solute Carrier Family 12 Member 72
K-Cl Cotransporter 42 3     

External Ids:    HGNC: 109151   Entrez Gene: 107232   Ensembl: ENSG000001135047   OMIM: 6048795   UniProtKB: Q9Y6663   

Export aliases for SLC12A7 gene to outside databases

Previous GC identifers: GC05M001254 GC05P001115 GC05M001083 GC05M001103 GC05M001032


Summaries
for SLC12A7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+)
uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the
survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for
basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)

Gene Wiki entry for SLC12A7


Genomic Views
for SLC12A7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC12A7 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   NF-E2 p45   HNF-4alpha1   Gfi-1   Cart-1   AP-2alpha isoform 4   AP-2alpha   NF-E2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC12A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC12A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC12A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15

SLC12A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC12A7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001050:  view genomic region     (about GC identifiers)

Start:
 1,050,489 bp from pter      End:
 1,112,172 bp from pter
Size:
 61,684 bases      Orientation:
 minus strand

Proteins
for SLC12A7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666 (See protein sequence)
Recommended Name: Solute carrier family 12 member 7  
Size: 1083 amino acids; 119106 Da
Subunit: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A6NDS8 Q4G0F3 Q96I81 Q9H7I3 Q9H7I7 Q9UFW2
Alternative splicing: 2 isoforms:  Q9Y666-1   Q9Y666-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC12A7: NX_Q9Y666

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y666

    • SLC12A7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006589.2  
    ENSEMBL proteins: 
     ENSP00000264930   ENSP00000428854  
    Reactome Protein details: Q9Y666
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC12A7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC12A7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10347194


    SLC12A7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SLC12A7

    Protein Domains /
    Families
    for SLC12A7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC12A7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000076 KCL_cotranspt
     IPR004841 AA-permease_dom
     IPR004842 Na/K/Cl_cotransptS

    Graphical View of Domain Structure for InterPro Entry Q9Y666

    ProtoNet protein and cluster: Q9Y666

    1 Blocks protein family: IPB000076 K-Cl co-transporter signature

    UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
    Similarity: Belongs to the SLC12A transporter family


    Function
    for SLC12A7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
    Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+)
    uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the
    survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for
    basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)
    Enzyme regulation: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The inhibition is
    much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by WNK3

         Genatlas biochemistry entry for SLC12A7:
    solute carrier family 12 (sodium/potassium/chloride cotransporter),highly expressed in muscle,brain,heart,lung and
    kidney,regulated in vascular endothelial cells by EGF

    miRNA
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    hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC12A7 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A7 (see all 2)
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    Cell Line
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    Search LifeMap BioReagents cell lines for SLC12A7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A7

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015379potassium:chloride symporter activity IEA--


    SLC12A7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC12A7:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Slc12a7tm1Tjj for SLC12A7
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc12a7):
     behavior/neurological  growth/size  hearing/vestibular/ear  homeostasis/metabolism  nervous system 
     renal/urinary system  vision/eye 

    SLC12A7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC12A7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    2Cation-coupled Chloride cotransporters
    		Cation-coupled Chloride cotransporters1.00
    3Insulin receptor recycling
    		Collecting duct acid secretion0.68
    4Amino acid and oligopeptide SLC transporters
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC12A7
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Cation-coupled Chloride cotransporters
    Transport of inorganic cations/anions and amino acids/oligopeptides


    1         Kegg Pathway  (Kegg details for SLC12A7):
        Collecting duct acid secretion


    SLC12A7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC12A7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SLC12A7 (Q9Y6663 ENSP000002649304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1AQ166653I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10347194
    GO:0006811ion transport TAS--
    GO:0006813potassium ion transport IEA--
    GO:0006884cell volume homeostasis IEA--
    GO:0055085transmembrane transport TAS--


    SLC12A7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC12A7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC12A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC12A7

    1 HMDB Compound for SLC12A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 DrugBank Compound for SLC12A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Potassium ChlorideChlorid draselny [Czech] (see all 9)7447-40-7target--17418819 16949074 16943364
    transportersubstrate17418819 16949074 16943364 17418819 16949074 16943364

    3 Novoseek chemical compound relationships for SLC12A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    furosemide 46.5 2 10913127 (1)
    phosphatidylinositol 30.4 1 17133354 (1)
    chloride 27.5 1 12709395 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC12A7 / S12A7 

    Transcripts
    for SLC12A7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC12A7 gene: 
    NM_006598.2  

    Unigene Cluster for SLC12A7:

    Solute carrier family 12 (potassium/chloride transporters), member 7
    Hs.172613  [show with all ESTs]
    Unigene Representative Sequence: NM_006598
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264930(uc003jbu.3) ENST00000514994 ENST00000513223 ENST00000504576
    ENST00000510943

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC12A7:
    hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC12A7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC12A7 (see all 4)
    OriGene shRNA RFP: SLC12A7
    OriGene siRNA: SLC12A7
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF105365.1 AK024493.1 AK024497.1 AK026625.1 AK302856.1 AL117433.1 BC007760.2 BC018982.2 
    BC098390.1 

    7 DOTS entries:

    DT.417207  DT.99972844  DT.120871124  DT.95259216  DT.95366517  DT.95366598  DT.100692023 

    24/252 AceView cDNA sequences (see all 252):

    AI480367 BM742091 AW662599 BU931988 BQ219432 AK024493 AI923407 AI492956 
    BF062992 BU687993 CB268290 BG830253 CB851679 BM988250 AL043236 AW473616 
    BG248758 AI014455 CD366310 BI793060 AW954145 BG741816 AI363258 CB529127 

    GeneLoc Exon Structure


    Expression
    for SLC12A7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC12A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCTGGCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC12A7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    mK4 (Cell line)Kidney
    mK3 (Cell line)Kidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC12A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC12A7

    SOURCE GeneReport for Unigene cluster: Hs.172613

    UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
    Tissue specificity: Detected in muscle, brain, lung, heart and kidney

        SABiosciences Custom PCR Arrays for SLC12A7
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A7

    Orthologs
    for SLC12A7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC12A7 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC12A71 solute carrier family 12 (potassium/chloride transporters), more 70.03(n)
    82.59(a)    		   420797  NM_001006371.2  NP_001006371.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC12A76
    		 --
    		 79(a)
    		 1 ↔ 1
    		 4(67863604-67937608)
    zebrafish
    (Danio rerio)    		 Actinopterygii 570972102   -- 77(n)    57097210 
    fruit fly
    (Drosophila melanogaster)    		 Insecta kcc6
    		 kazachoc
    		 51(a)
    		 1 → many
    		 2R(19795651-19812619)
    worm
    (Caenorhabditis elegans)    		 Secernentea H16O14.13   -- 46(a)
    (best of 3)    		   IV(6065705-6074152)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CCC16
    		 cation-chloride co-transporter 1
    		 34(a)
    		 1 → many
    		 1(10762739-10769532)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 amino acid permease family protein, putative
    		 34(a)
    33(a)
    		 many ↔ many
    many ↔ many
    		 8(14183430-14192706)
    1(11253120-11260660)


    ENSEMBL Gene Tree for SLC12A7 (if available)
    TreeFam Gene Tree for SLC12A7 (if available) 

    Paralogs
    for SLC12A7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC12A7 gene
    SLC12A12  SLC12A42  SLC12A52  SLC12A82  SLC12A32  SLC12A92  SLC12A62  SLC12A22  
    4 SIMAP similar genes for SLC12A7 using alignment to 3 protein entries:     S12A7_HUMAN (see all proteins):
    SLC12A5    DKFZp686O1827    SLC12A6    SLC12A4

    SLC12A7 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC12A7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1859 NCBI SNPs in SLC12A7 are shown (see all 1859)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs800908011,2
    		C,F,--1035488(+) GCAGAA/GGTGGC 1 -- ds50015Minor allele frequency- G:0.22WA CSA EA 245
    rs779562781,2
    		F,--1035489(+) CAGAAG/TTGGCG 1 -- ds50011Minor allele frequency- T:0.03EA 120
    rs1127994131,2
    		--1035632(+) GCAAGC/TGCTTT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1114609981,2
    		--1035998(+) TCCTAC/TGGCCC 1 -- nc-transcript-variant2Minor allele frequency- T:0.06CSA EA 122
    rs755243051,2
    		F,--1036818(+) AAGTGA/GAAGCA 1 -- nc-transcript-variant1Minor allele frequency- G:0.05WA 118
    rs1113787681,2
    		--1037103(+) AAATGC/TGTGCA 1 -- nc-transcript-variant2Minor allele frequency- T:0.06CSA EA 122
    rs1136237151,2
    		--1037232(+) AGCACG/ACACAC 1 -- nc-transcript-variant2Minor allele frequency- A:0.04CSA WA 120
    rs1133250041,2
    		--1037944(+) CCCCGG/AAGCTC 1 -- us2k12Minor allele frequency- A:0.06CSA EA 122
    rs125151971,2
    		C,F,H,--1038116(+) CCCTGC/TGAGGC 1 -- us2k16Minor allele frequency- T:0.10WA NA CSA 246
    rs100703551,2
    		C,--1038322(+) TGCACG/AGGGCA 1 -- us2k12Minor allele frequency- A:0.21CSA WA 120

    HapMap Linkage Disequilibrium report for SLC12A7 (1050489 - 1112172 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 20 variations for SLC12A7
         10 CNVs: 68955 32694 2081 3537 68957 33931 68958 23747 31218 53332
         10 Indels: 27766 68956 62329 12641 27768 41797 12642 12643 46756 40725

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    Disorders / Diseases
    for SLC12A7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC12A7 for disorders           About GeneDecksing

    OMIM gene information: 604879    OMIM disorders: --

    7 diseases for SLC12A7:    About MalaCards
    renal tubular acidosis    hermaphroditism    cervical cancer    cervicitis
    ovarian cancer    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC12A7:
    Renal tubular acidosis
    Human Genome Epidemiology (HuGE) Navigator: SLC12A7 (1 document)

    Export disorders for SLC12A7 gene to outside databases

    Publications
    for SLC12A7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC12A7 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with SLC12A7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. (PubMed id 10347194)1, 2, 3, 9 Mount D.B....Gamba G. (1999)
    2. Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4. (PubMed id 10913127)1, 2, 9 Mercado A.... Gamba G. (2000)
    3. Similar Effects of all WNK3 Variants upon SLC12 Cotransporters. (PubMed id 21613606)1, 2 Cruz-Rangel S.... Mercado A. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    6. Motor protein-dependent membrane trafficking of KCl c otransporter-4 is important for cancer cell invasion. (PubMed id 19887603)1, 9 Chen Y.F....Shen M.R. (2009)
    7. Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells. (PubMed id 18984587)1, 9 Fujii T....Sakai H. (2009)
    8. IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness. (PubMed id 17133354)1, 9 Hsu Y.M....Shen M.R. (2007)
    9. KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts. (PubMed id 16949074)7, 9 Misri S....Lauf P.K. (2006)
    10. Functional and molecular characterization of multiple K-Cl cotransporter isoforms in corneal epithelial cells. (PubMed id 17418819)7, 9 Capo-Aponte J.E....Reinach P.S. (2007)

    External Searches for SLC12A7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing SLC12A7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10723 HGNC: 10915 AceView: SLC12A7 Ensembl:ENSG00000113504 euGenes: HUgn10723
    ECgene: SLC12A7 Kegg: 10723 H-InvDB: SLC12A7

    Other Databases showing SLC12A7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC12A7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC12A7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC12A7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC12A7 gene:
    Search GeneIP for patents involving SLC12A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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