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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC12A7 Gene

protein-coding   GIFtS: 65
GCID: GC05M001050

Solute Carrier Family 12 (Potassium/Chloride Transporter),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 71 2     Potassium/Chloride Transporter KCC42
KCC42 3 5     Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 72
Electroneutral Potassium-Chloride Cotransporter 42 3     Solute Carrier Family 12 Member 72
K-Cl Cotransporter 42 3     

External Ids:    HGNC: 109151   Entrez Gene: 107232   Ensembl: ENSG000001135047   OMIM: 6048795   UniProtKB: Q9Y6663   

Export aliases for SLC12A7 gene to outside databases

Previous GC identifers: GC05M001254 GC05P001115 GC05M001083 GC05M001103 GC05M001032


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC12A7 Gene: 
SLC12A7 (solute carrier family 12 (potassium/chloride transporter), member 7) is a protein-coding gene. Diseases associated with SLC12A7 include renal tubular acidosis, and cervical cancer, and among its related super-pathways are Transmembrane transport of small molecules and Insulin receptor recycling. GO annotations related to this gene include potassium:chloride symporter activity. An important paralog of this gene is SLC12A3.

UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+)
uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the
survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for
basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)

Gene Wiki entry for SLC12A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC12A7 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   NF-E2 p45   HNF-4alpha1   Gfi-1   Cart-1   AP-2alpha isoform 4   AP-2alpha   NF-E2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC12A7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC12A7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC12A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15

SLC12A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC12A7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001050:  view genomic region     (about GC identifiers)

Start:
1,050,489 bp from pter      End:
1,112,172 bp from pter
Size:
61,684 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666 (See protein sequence)
Recommended Name: Solute carrier family 12 member 7  
Size: 1083 amino acids; 119106 Da
Subunit: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A6NDS8 Q4G0F3 Q96I81 Q9H7I3 Q9H7I7 Q9UFW2
Alternative splicing: 2 isoforms:  Q9Y666-1   Q9Y666-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC12A7: NX_Q9Y666

Explore proteomics data for SLC12A7 at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylation at Asn-331 and Asn-344 is required for proper trafficking to the cell surface
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y666

  • SLC12A7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC12A7 Protein Expression
    REFSEQ proteins: NP_006589.2  
    ENSEMBL proteins: 
     ENSP00000264930   ENSP00000428854  
    Reactome Protein details: Q9Y666
    Human Recombinant Protein Products for SLC12A7: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10347194
    GO:0016020membrane ----
    GO:0016021integral to membrane ----

    SLC12A7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: K-Cl cotransporter 4 
    SLC12 family of cation-coupled chloride transporters

    3 InterPro protein domains:
     IPR000076 KCL_cotranspt
     IPR004841 AA-permease_dom
     IPR004842 Na/K/Cl_cotransptS

    Graphical View of Domain Structure for InterPro Entry Q9Y666

    ProtoNet protein and cluster: Q9Y666

    1 Blocks protein domain: IPB000076 K-Cl co-transporter signature

    UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
    Similarity: Belongs to the SLC12A transporter family


    SLC12A7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S12A7_HUMAN, Q9Y666
    Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+)
    uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the
    survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for
    basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity)
    Enzyme regulation: Activated by N-ethylmaleimide (NEM). Inhibited by furosemide, DIDS and bumetanide. The
    inhibition is much stronger in the presence of 50 mM K(+) in the uptake medium. Inhibited by DIOA. Inhibited by
    WNK3

         Genatlas biochemistry entry for SLC12A7:
    solute carrier family 12 (sodium/potassium/chloride cotransporter),highly expressed in muscle,brain,heart,lung and
    kidney,regulated in vascular endothelial cells by EGF

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015377cation:chloride symporter activity ----
    GO:0015379potassium:chloride symporter activity IEA--
         
    SLC12A7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC12A7:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc12a7):
     behavior/neurological  growth/size  hearing/vestibular/ear  homeostasis/metabolism  nervous system 
     renal/urinary system  vision/eye 

    SLC12A7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc12a7tm1Tjj for SLC12A7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC12A7 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC12A7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC12A7 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC12A7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50
    2Insulin receptor recycling
    Collecting duct acid secretion0.68
    3Amino acid and oligopeptide SLC transporters
    Transport of inorganic cations/anions and amino acids/oligopeptides0.52
    4Cation-coupled Chloride cotransporters
    Cation-coupled Chloride cotransporters

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC12A7
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Cation-coupled Chloride cotransporters
    Transport of inorganic cations/anions and amino acids/oligopeptides


    1         Kegg Pathway  (Kegg details for SLC12A7):
        Collecting duct acid secretion


    SLC12A7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC12A7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for SLC12A7 (Q9Y6663 ENSP000002649304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIF1AQ166653I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS10347194
    GO:0006811ion transport TAS--
    GO:0006813potassium ion transport IEA--
    GO:0006884cell volume homeostasis IEA--
    GO:0055085transmembrane transport TAS--

    SLC12A7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC12A7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC12A7 (S12A7)

    1 HMDB Compound for SLC12A7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 DrugBank Compound for SLC12A7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Potassium ChlorideChlorid draselny [Czech] (see all 9)7447-40-7target--17418819 16949074 16943364
    transportersubstrate17418819 16949074 16943364 17418819 16949074 16943364

    1 IUPHAR Ligand for SLC12A7 (K-Cl cotransporter 4)    About this table 
    LigandTypeActionAffinityPubmed IDs
    DIOA
    InhibitorInhibition--

    3 Novoseek inferred chemical compound relationships for SLC12A7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    furosemide 46.5 2 10913127 (1)
    phosphatidylinositol 30.4 1 17133354 (1)
    chloride 27.5 1 12709395 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC12A7 / S12A7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC12A7 gene: 
    NM_006598.2  

    Unigene Cluster for SLC12A7:

    Solute carrier family 12 (potassium/chloride transporters), member 7
    Hs.172613  [show with all ESTs]
    Unigene Representative Sequence: NM_006598
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264930(uc003jbu.3) ENST00000514994 ENST00000513223 ENST00000504576
    ENST00000510943
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    Additional mRNA sequence: 

    AF105365.1 AK024493.1 AK024497.1 AK026625.1 AK302856.1 AL117433.1 BC007760.2 BC018982.2 
    BC098390.1 

    7 DOTS entries:

    DT.417207  DT.99972844  DT.120871124  DT.95259216  DT.95366517  DT.95366598  DT.100692023 

    24/252 AceView cDNA sequences (see all 252):

    BF061743 AW662599 AI014455 CB529127 AI401790 BG830253 BM673571 AI363258 
    CB268290 CA947002 BM764365 AA349584 AI923407 BG981485 BX332206 BG741816 
    BG248758 BF062992 AI492956 BM830125 BM742091 AK024497 BM850709 AA678767 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC12A7 expression in normal human tissues (normalized intensities)      SLC12A7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGGCTC
    SLC12A7 Expression
    About this image


    SLC12A7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             mK3
     
     Heart (Cardiovascular System)
             left ventricular apex samples   
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

    See SLC12A7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC12A7

    SOURCE GeneReport for Unigene cluster: Hs.172613

    UniProtKB/Swiss-Prot: S12A7_HUMAN, Q9Y666
    Tissue specificity: Detected in muscle, brain, lung, heart and kidney

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC12A7 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc12a71 , 5 solute carrier family 12, member 71, 5 84.64(n)1
    91.04(a)1
      13 (40.15 cM)5
    204991  NM_011390.21  NP_035520.11 
     737636975 
    chicken
    (Gallus gallus)
    Aves SLC12A71 solute carrier family 12 (potassium/chloride transporters), more 70.03(n)
    82.59(a)
      420797  NM_001006371.2  NP_001006371.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC12A76
    Uncharacterized protein
    78(a)
    1 ↔ 1
    4(67861091-67937608)
    zebrafish
    (Danio rerio)
    Actinopterygii 570972102   -- 77(n)    57097210 
    fruit fly
    (Drosophila melanogaster)
    Insecta kcc6
    kazachoc
    52(a)
    1 → many
    2R(19795651-19812619)
    worm
    (Caenorhabditis elegans)
    Secernentea H16O14.13   -- 46(a)
    (best of 3)
      IV(6065705-6074152)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YBR235W6
    Putative ion transporter, similar to mammalian ele...
    19(a)
    1 → many
    II(686901-690263)


    ENSEMBL Gene Tree for SLC12A7 (if available)
    TreeFam Gene Tree for SLC12A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC12A7 gene
    SLC12A32  SLC12A92  SLC12A62  SLC12A22  SLC12A82  SLC12A12  SLC12A42  SLC12A52  
    4 SIMAP similar genes for SLC12A7 using alignment to 3 protein entries:     S12A7_HUMAN (see all proteins):
    SLC12A5    DKFZp686O1827    SLC12A6    SLC12A4

    SLC12A7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2122 SNPs in SLC12A7 are shown (see all 2122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838988271,2
    --1049995(+) TGGCCA/GGGCAT 1 -- int10--------
    rs354282491,2
    F--1050162(+) TATTCG/AGGAGG 1 -- int12Minor allele frequency- A:0.50NA 4
    rs1878920981,2
    --1050188(+) AGCTTC/GAACCT 1 -- int10--------
    rs1926700921,2
    --1050225(+) GGTGAC/TGCCAC 1 -- int10--------
    rs68594001,2
    C,F,H--1050275(+) CAGAGA/GTTGGG 1 -- int115Minor allele frequency- G:0.13EA NS NA WA 1994
    rs1398262821,2
    --1050332(+) AAGCCA/GATGAC 1 -- int10--------
    rs1163932061,2
    F--1050414(+) CCTGAC/TGCTCC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1849612621,2
    --1050434(+) AGGGGC/TGGCCA 1 -- int10--------
    rs1897933701,2
    --1050487(+) GAGATA/TCTTCA 1 -- spd10--------
    rs3714067411,2
    C--1050615(+) CAACA-/AAAG  
     G
    /AAGGA
    AAGGA
    3 -- ut31 cds10--------

    HapMap Linkage Disequilibrium report for SLC12A7 (1050489 - 1112172 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/70 variations for SLC12A7 (see all 70):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3216CNV Deletion18987735
    esv2729409CNV Deletion23290073
    esv2729413CNV Deletion23290073
    esv1017705CNV Deletion17803354
    dgv959e201CNV Deletion23290073
    esv2658162CNV Deletion23128226
    esv2729419CNV Deletion23290073
    esv2729412CNV Deletion23290073
    esv2729414CNV Deletion23290073
    esv2729422CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604879    OMIM disorders: --

    6 diseases for SLC12A7:    About MalaCards
    renal tubular acidosis    cervical cancer    cervicitis    ovarian cancer
    endotheliitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SLC12A7:
    Renal tubular acidosis

    SLC12A7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC12A7
    Human Genome Epidemiology (HuGE) Navigator: SLC12A7 (1 document)

    Export disorders for SLC12A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC12A7 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with SLC12A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. (PubMed id 10347194)1, 2, 3, 9 Mount D.B....Gamba G. (1999)
    2. Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4. (PubMed id 10913127)1, 2, 9 Mercado A.... Gamba G. (2000)
    3. Similar Effects of all WNK3 Variants upon SLC12 Cotransporters. (PubMed id 21613606)1, 2 Cruz-Rangel S.... Mercado A. (2011)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    5. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
    8. Motor protein-dependent membrane trafficking of KCl c otransporter-4 is important for cancer cell invasion. (PubMed id 19887603)1, 9 Chen Y.F....Shen M.R. (2009)
    9. Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells. (PubMed id 18984587)1, 9 Fujii T....Sakai H. (2009)
    10. IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness. (PubMed id 17133354)1, 9 Hsu Y.M....Shen M.R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10723 HGNC: 10915 AceView: SLC12A7 Ensembl:ENSG00000113504 euGenes: HUgn10723
    ECgene: SLC12A7 Kegg: 10723 H-InvDB: SLC12A7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC12A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC12A7 gene:
    Search GeneIP for patents involving SLC12A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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