SLC12A5 Gene
protein-coding GIFtS: 57
GCID: GC20P044651
|
|
solute carrier family 12 (potassium/chloride transporter),...
| |
Aliases
for SLC12A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 51 2 | | HKCC21 | | KCC21 2 3 5 | | K-Cl Cotransporter 22 3 | | KIAA11761 3 5 | | Erythroid K-Cl Cotransporter 22 | | Electroneutral Potassium-Chloride Cotransporter 22 3 | | Solute Carrier Family 12 Member 52 | | Neuronal K-Cl Cotransporter2 3 | | |
Export aliases for SLC12A5 gene to outside databasesPrevious GC identifers: GC20P044386 GC20P045296 GC20P045343 GC20P044091 GC20P041391 |
Summaries
for SLC12A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC12A5:
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibriumpotential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either anet efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encodedprotein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloridehomeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. (providedby RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: S12A5_HUMAN, Q9H2X9Function: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonicconditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons
Gene Wiki entry for SLC12A5 (Chloride potassium symporter 5)
|
Genomic Views
for SLC12A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC12A5 gene promoter:
CREB NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC12A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC12A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12SLC12A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P044651: view genomic region
(about GC identifiers)
Start:
|
44,650,329 bp from pter |
End:
|
44,688,789 bp from pter |
Size:
|
38,461 bases |
Orientation:
|
plus strand |
|
Proteins
for SLC12A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S12A5_HUMAN, Q9H2X9 (See
protein sequence)Recommended Name: Solute carrier family 12 member 5 Size: 1139 amino acids; 126184 Da
Subunit: Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Inhibited by furosemide and bumetanide
Secondary accessions: A2RTX2 Q5VZ41 Q9H4Z0 Q9ULP4Alternative splicing: 2 isoforms: Q9H2X9-1 Q9H2X9-2 (Ref.1 (AAG43493) sequence is in conflict in position: 2:L->P)Explore the universe of human proteins at neXtProt for SLC12A5: NX_Q9H2X9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H2X9
SLC12A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001128243.1 NP_065759.1
ENSEMBL proteins: ENSP00000361389 ENSP00000243964 ENSP00000387694 ENSP00000446091 Reactome Protein details: Q9H2X9
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SLC12A5 for ontologies About GeneDecksing
SLC12A5 Antibody Products:
Assay Products for SLC12A5: |
Protein
Domains /
Families
for SLC12A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC12A5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H2X9ProtoNet protein and cluster: Q9H2X9 1 Blocks protein family: IPB000076 K-Cl co-transporter signature
UniProtKB/Swiss-Prot: S12A5_HUMAN, Q9H2X9Similarity: Belongs to the SLC12A transporter family |
Function
for SLC12A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S12A5_HUMAN, Q9H2X9Function: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonicconditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neuronsEnzyme regulation: Inhibited by WNK3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SLC12A5 (NM_020708) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC12A5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC12A5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SLC12A5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SLC12A5: Slc12a5tm1Tjj Slc12a5tm1Dlp
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Slc12a5):
SLC12A5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC12A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Cation-coupled Chloride cotransporters | | | 3 | Synaptic transmission: ion currents | | | 4 | Amino acid and oligopeptide SLC transporters | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SLC12A5
4 
Reactome Pathways for SLC12A5
SLC12A5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC12A5
3 Interacting proteins for SLC12A5 (Q9H2X93) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
SLC12A5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC12A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SLC12A5 for compounds About GeneDecksing
 Browse Tocris compounds for SLC12A5
2 HMDB Compounds for SLC12A5 About this table
2 DrugBank Compounds for SLC12A5 About this table
10 Novoseek chemical compound relationships for SLC12A5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bumetanide |
82.9 |
1 |
18840481 (1) |
| potassium chloride |
79.2 |
16 |
19767413 (2), 18063479 (1), 18602983 (1), 20086212 (1) (see all 9) |
| gaba |
78.6 |
45 |
19679663 (4), 18755547 (4), 15932617 (3), 16081002 (3) (see all 21) |
| chloride |
78.1 |
34 |
18772206 (3), 19923298 (2), 18769373 (2), 17093093 (1) (see all 20) |
| furosemide |
71.3 |
5 |
15175220 (2), 18840481 (1), 16905250 (1) |
| glutamate |
38.4 |
2 |
18772206 (2) |
| strychnine |
38.1 |
2 |
12401451 (1), 16905250 (1) |
| bicuculline |
35.3 |
3 |
16905250 (1), 18755547 (1) |
| tyrosine |
3.96 |
11 |
19679663 (6), 10942735 (2), 18063479 (1) |
| calcium |
0 |
4 |
18076645 (1), 17855601 (1), 19376067 (1), 15932617 (1) |
Search CenterWatch for drugs/clinical trials and news about SLC12A5 / S12A5
|
Transcripts
for SLC12A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC12A5 gene (2 alternative transcripts): NM_001134771.1 NM_020708.4 Unigene Cluster for SLC12A5: Solute carrier family 12 (potassium/chloride transporter), member 5 Hs.21413 [show with all ESTs]Unigene Representative Sequence: NM_0207084 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372315(uc002xra.2) ENST00000243964(uc010zxm.1 uc002xrb.2)
ENST00000454036(uc010zxl.1) ENST00000539566
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC12A5 (NM_020708) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC12A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC12A5 |
Additional cDNA sequence: AB033002.1 AF208159.1 AK055066.1 AK289758.1 AK294059.1 AK295096.1 AK295900.1 AK296331.1 BC036329.1 BC132668.1 BC132670.1 U79245.1 12 DOTS entries: DT.115090 DT.97841683 DT.120817721 DT.120817448 DT.120817873 DT.40246449 DT.95094916 DT.95253335 DT.95359806 DT.99935455 DT.213088 DT.97784737 24/104 AceView cDNA sequences (see all 104): BC036329 BM725637 NM_020708 AK098371 AB033002 H85788 AA322772 Z43090 AL711911 AA322789 BM661553 AA166885 AA708345 BI758196 H84882 BM695423 BI754995 AA788885 F10893 BV168425 U79245 AV750287 BM689499 AA010975
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC12A5 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 |
|---|
|
| SP1: | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC12A5
|
Expression
for SLC12A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC12A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLC12A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC12A5
SOURCE GeneReport for Unigene cluster: Hs.21413
UniProtKB/Swiss-Prot: S12A5_HUMAN, Q9H2X9Tissue specificity: Brain specific. Detected in neuronal cells
SABiosciences Expression via Pathway-Focused PCR Array including SLC12A5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC12A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC12A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC12A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC12A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A5 |
Orthologs
for SLC12A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC12A5 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SLC12A51 |
solute carrier family 12 (potassium/chloride transporter), more |
84.95(n)
94.06(a) |
|
777252 XM_001236721.2 XP_001236722.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SLC12A56 |
-- |
87(a) |
1 ↔ 1 |
GL343741.1(2308-66963) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5722151 |
solute carrier family 12 member 5-like |
74.06(n)
78.72(a) |
|
572215 XM_695908.4 XP_701000.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
kcc6 |
kazachoc |
52(a) |
1 → many |
2R(19795651-19812619) |
worm
(Caenorhabditis elegans) |
Secernentea |
H16O14.13 |
-- |
45(a)
(best of 3) |
|
IV(6065705-6074152) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CCC11 |
cation-chloride co-transporter 1 |
48.45(n)
40.05(a) |
|
839924 NM_102781.2 NP_174333.2 |
rice
(Oryza sativa) |
Liliopsida |
Os08g03237001 |
hypothetical protein |
45.9(n)
29.97(a) |
|
4345272 NM_001068078.1 NP_001061543.1 |
ENSEMBL Gene Tree for SLC12A5 (if available)
TreeFam Gene Tree for SLC12A5 (if available) |
Paralogs
for SLC12A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC12A5 gene
- SLC12A72 SLC12A12 SLC12A42 SLC12A82 SLC12A32 SLC12A92 SLC12A62 SLC12A22
7 SIMAP similar genes for SLC12A5 using alignment to 3 protein entries: S12A5_HUMAN (see all proteins):SLC12A7 DKFZp686O1827 SLC12A4 SLC12A6 SLC12A3 SLC12A1
SLC12A2
SLC12A5 for paralogs About GeneDecksing
|
Genomic Variants
for SLC12A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC12A5 (44650329 - 44688789 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC12A5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC12A5 |
|
Disorders
/ Diseases
for SLC12A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC12A5 for disorders About GeneDecksing
OMIM gene information: 606726
OMIM disorders: --
12  diseases for SLC12A5: About MalaCardsneuronitis cleft lip/palate focal cortical dysplasia hypothalamic hamartomas
temporal lobe epilepsy cleft lip intractable epilepsy brain injury
neurologic diseases hermaphroditism seizures retinitis
1 disease from the University of Copenhagen DISEASES database for SLC12A5:Gitelman syndrome 2 Novoseek disease relationships for SLC12A5 gene About this table
Human Genome Epidemiology (HuGE) Navigator: SLC12A5 (5 documents)
Export disorders for SLC12A5 gene to outside databases
|
Publications
for SLC12A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC12A5 gene, integrated from 9 sources (see all 112):
(articles sorted by number of sources associating them with SLC12A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Similar Effects of all WNK3 Variants upon SLC12 Cotransporters. (PubMed id 21613606)1, 2 Cruz-Rangel S.... Mercado A. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 2 Kimura K.... Sugano S. (2006)
- Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. (PubMed id 12106695)1, 2 Song L.... Mount D.B. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport. (PubMed id 16291749)1, 9 Mercado A....Mount D.B. (2006)
- Opposite effect of membrane raft perturbation on tran sport activity of KCC2 and NKCC1. (PubMed id 19686239)1, 9 Hartmann A.M....Nothwang H.G. (2009)
- KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses. (PubMed id 15932617)1, 9 Lee H....Kandler K. (2005)
- Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology. (PubMed id 11701957)1, 9 Sallinen R....Wessman M. (2001)
- A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. (PubMed id 17715129)1, 9 Uvarov P....Airaksinen M.S. (2007)
|
External Searches for SLC12A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC12A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SLC12A5 gene
(According to HUGE)
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Specialized Databases showing SLC12A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SLC12A5 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SLC12A5 gene:
Search GeneIP for patents involving SLC12A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SLC12A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC12A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC12A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC12A5 | | | OriGene Protein Over-expression Lysate for SLC12A5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC12A5 | | OriGene 3'-UTR Clone for SLC12A5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC12A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC12A5 | | OriGene Custom Protein Services for SLC12A5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC12A5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC12A5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC12A5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC12A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC12A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC12A5 |
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| | | | Search Tocris compounds for SLC12A5 |
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 | | | SLC12A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC12A5 |
|  |  |  | | | | ThermoFisher Antibodies for SLC12A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC12A5 |
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