Aliases for SLC12A4 Gene
- Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 4 2 3
- Electroneutral Potassium-Chloride Cotransporter 1 3 4
- Erythroid K-Cl Cotransporter 1 3 4
- HKCC1 3 4
- KCC1 3 4
- Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 4 3
- Potassium/Chloride Cotransporter 1 3
- CTC-479C5.17 3
External Ids for SLC12A4 Gene
Previous GeneCards Identifiers for SLC12A4 Gene
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
GeneCards Summary for SLC12A4 Gene
SLC12A4 (Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein kinase binding and cation:chloride symporter activity. An important paralog of this gene is SLC12A2.
UniProtKB/Swiss-Prot for SLC12A4 Gene
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.