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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC12A4 Gene

protein-coding GIFtS: 62
GCID: GC16M067979

solute carrier family 12 (potassium/chloride transporters),...

Explore 8 diseases affiliated with
SLC12A4 via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 4¹ ²		HKCC1¹
KCC1¹ ² ³ ⁵		Potassium/Chloride Cotransporter 1²
Electroneutral Potassium-Chloride Cotransporter 1² ³		Solute Carrier Family 12 Member 4²
Erythroid K-Cl Cotransporter 1² ³

External Ids:	HGNC: 10913¹	Entrez Gene: 6560²	Ensembl: ENSG00000124067⁷	OMIM: 604119⁵	UniProtKB: Q9UP95³

Export aliases for SLC12A4 gene to outside databases

Previous GC identifers: GC16M058673 GC16M068355 GC16M067713 GC16M067754 GC16M066535 GC16M053850

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC12A4:

This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of

potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively

spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jan 2013)

UniProtKB/Swiss-Prot: S12A4_HUMAN, Q9UP95

Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to

cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing

epithelia (By similarity). Isoform 4 has no transport activity

Gene Wiki entry for SLC12A4 (Chloride potassium symporter 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC12A4 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 4 AP-2alpha isoform 2 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC12A4 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC12A4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC12A4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

SLC12A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC12A4 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M067979: view genomic region (about GC identifiers)

Start:	67,977,377 bp from pter	End:	68,003,504 bp from pter
Size:	26,128 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S12A4_HUMAN, Q9UP95 (See protein sequence)

Recommended Name: Solute carrier family 12 member 4

Size: 1085 amino acids; 120650 Da

Subunit: Homomultimer and heteromultimer with other K-Cl cotransporters

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAC35282.1; Type=Frameshift; Positions=454;

Secondary accessions: B4DR04 B4DZ82 B7ZAV0 F5H066 F5H0S9 O60632 O75893 Q13953 Q96LD5

Alternative splicing: 6 isoforms: Q9UP95-1 Q9UP95-2 Q9UP95-3 Q9UP95-4 Q9UP95-5 Q9UP95-6 (No experimental confirmation available. Ref.3 (BAH14786) sequence is in conflict in position: 4:E->G)

Explore the universe of human proteins at neXtProt for SLC12A4: NX_Q9UP95

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UP95

SLC12A4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001139433.1 NP_001139434.1 NP_001139435.1 NP_001139436.1 NP_005063.1

ENSEMBL proteins:

ENSP00000318557 ENSP00000461403 ENSP00000438334 ENSP00000458902 ENSP00000445962

ENSP00000463148 ENSP00000464660 ENSP00000458975 ENSP00000464168 ENSP00000395983

ENSP00000343374

Reactome Protein details: Q9UP95
Human Recombinant Protein Products for SLC12A4:

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	Uscn Proteins for SLC12A4

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8663127
GO:0016020	membrane	TAS	8663127
GO:0016021	integral to membrane	--	--

SLC12A4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC12A4 for domains About GeneDecksing

5 InterPro domains/families:

IPR000622 K/Cl_cotranspt1

IPR000076 KCL_cotranspt

IPR004841 AA-permease_dom

IPR004842 Na/K/Cl_cotransptS

IPR018491 K/Cl_cotranspt_1/3

Graphical View of Domain Structure for InterPro Entry Q9UP95

ProtoNet protein and cluster: Q9UP95

2 Blocks protein families:

IPB000076 K-Cl co-transporter signature

IPB000622 K-Cl co-transporter type 1 (KCC1) signature

UniProtKB/Swiss-Prot: S12A4_HUMAN, Q9UP95

Similarity: Belongs to the SLC12A transporter family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: S12A4_HUMAN, Q9UP95

Function: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to

cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing

epithelia (By similarity). Isoform 4 has no transport activity

Enzyme regulation: Inhibited by WNK3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015379	potassium:chloride symporter activity	IEA	--

SLC12A4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLC12A4:

Decreased influenza A/WSN/33 r

Animal Models:

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Cation-coupled Chloride cotransporters

Cation-coupled Chloride cotransporters

1.00

Amino acid and oligopeptide SLC transporters

Transport of inorganic cations/anions and amino acids/oligopeptides

0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SLC12A4

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Cation-coupled Chloride cotransporters
	Transport of inorganic cations/anions and amino acids/oligopeptides

SLC12A4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLC12A4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

3 Interacting proteins for SLC12A4 (Q9UP95^{2, 3} ENSP00000318557⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATF7IP	Q6VMQ6²^,³	MINT-61899 I2D: score=3
CKB	P12277³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	TAS	8663127
GO:0006811	ion transport	TAS	--
GO:0006813	potassium ion transport	IEA	--
GO:0006884	cell volume homeostasis	TAS	9516379
GO:0055085	transmembrane transport	TAS	--

SLC12A4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC12A4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC12A4

1 HMDB Compound for SLC12A4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Chlorine	Cl2 (see all 13)	16887-00-6	--

2 DrugBank Compounds for SLC12A4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Potassium Chloride	Chlorid draselny [Czech] (see all 9)	7447-40-7	target	--	17418819 16949074 16943364
Potassium Chloride	Chlorid draselny [Czech] (see all 9)	7447-40-7	transporter	substrate	17418819 16949074 16943364 17418819 16949074 16943364
Bumetanide	Bumetanida [INN-Spanish] (see all 2)	28395-03-1	target	inhibitor	10793196 16807348

6 Novoseek chemical compound relationships for SLC12A4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
n-ethylmaleimide	78.9	4	11410710 (1), 9950760 (1), 10564083 (1)
bumetanide	74.2	2	8663127 (1), 10913127 (1)
potassium chloride	70.9	5	14976052 (2), 18923037 (1)
furosemide	61.4	1	10913127 (1)
calyculin a	57.6	1	10564083 (1)
potassium	5.91	4	10973789 (1), 16364949 (1)

Search CenterWatch for drugs/clinical trials and news about SLC12A4 / S12A4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC12A4 gene (5 alternative transcripts):

NM_001145961.1 NM_001145962.1 NM_001145963.1 NM_001145964.1 NM_005072.4

Unigene Cluster for SLC12A4:

Solute carrier family 12 (potassium/chloride transporters), member 4

Hs.10094 [show with all ESTs]

Unigene Representative Sequence: NM_005072

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000316341 ENST00000572037 ENST00000541864 ENST00000576616(uc002eva.2)

ENST00000570802 ENST00000537830(uc002evb.2) ENST00000570616 ENST00000575857

ENST00000573023 ENST00000576513 ENST00000572476 ENST00000574665 ENST00000572766

ENST00000573702 ENST00000576377 ENST00000571299 ENST00000572010(uc010cew.1)

ENST00000576462

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Additional cDNA sequence:

AF047338.1 AF053402.1 AK026911.1 AK097808.1 AK124821.1 AK293906.1 AK293956.1 AK299042.1

AK302790.1 AK310027.1 AK311073.1 AK316415.1 AY026038.1 BC021193.2 U55054.1

20 DOTS entries:

DT.75157243 DT.100785102 DT.92378138 DT.100841838 DT.95192460 DT.95192461 DT.70102444 DT.102829038

DT.120672142 DT.91987825 DT.92431083 DT.100785105 DT.92391473 DT.100785103 DT.100799331 DT.446537

DT.120672110 DT.91727543 DT.95258264 DT.95362242

24/205 AceView cDNA sequences (see all 205):

BM830708 BM921605 BC035480 BC021193 CA454853 CD359822 BQ707084 BE253319

CA421717 AK097808 BP379463 CA395804 BC014781 H41220 NM_000229 CO247030

BU731894 BU733031 AF047338 NM_005072 AA831103 F08392 BM825709 BU617122

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for SLC12A4 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	^
SP1:
SP2:																																													-
SP3:																																													-
SP4:							-						-		-										-
SP5:																									-

ExUns:	12	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c	·	14d	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25a	·	25b	^	26a	·	26b
SP1:			-																																										-
SP2:			-
SP3:			-
SP4:
SP5:

ECgene alternative splicing isoforms for SLC12A4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC12A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTCCTCG

About this image

SLC12A4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Trachea

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC12A4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC12A4

SOURCE GeneReport for Unigene cluster: Hs.10094

UniProtKB/Swiss-Prot: S12A4_HUMAN, Q9UP95

Tissue specificity: Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to

normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell

disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC12A4 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC12A4¹	solute carrier family 12 (potassium/chloride transporters), more	73.46(n) 85.44(a)		415715 XM_003641916.1 XP_003641964.1
lizard (Anolis carolinensis)	Reptilia	SLC12A4⁶	--	85(a)	1 ↔ 1	LGc(6102720-6152320)
zebrafish (Danio rerio)	Actinopterygii	Dr.20057²	Transcribed sequence with moderate similarity to protein more	77.79(n)		CF543890.1
fruit fly (Drosophila melanogaster)	Insecta	kcc¹	kazachoc	59.65(n) 58.11(a)		37800 NM_166631.1 NP_726378.1
worm (Caenorhabditis elegans)	Secernentea	H16O14.1³ kcc-2¹	Protein KCC-2¹	48(a) (best of 3)³ 51.89(n)¹ 50.17(a)¹		IV(6065705-6074152)³ 177370¹ NM_068509.4¹ NP_500910.3¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CCC1⁶	cation-chloride co-transporter 1	34(a)	1 → many	1(10762739-10769532)
rice (Oryza sativa)	Liliopsida	-- --	amino acid permease family protein, putative	33(a) 32(a)	many ↔ many many ↔ many	8(14183430-14192706) 1(11253120-11260660)

ENSEMBL Gene Tree for SLC12A4 (if available)
TreeFam Gene Tree for SLC12A4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SLC12A4 gene

SLC12A7² SLC12A1² SLC12A5² SLC12A8² SLC12A3² SLC12A9² SLC12A6² SLC12A2²

6 SIMAP similar genes for SLC12A4 using alignment to 8 protein entries: S12A4_HUMAN (see all proteins):

DKFZp686O1827 SLC12A6 SLC12A7 SLC12A5 SLC12A9 SLC12A8

SLC12A4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201771708^1,2	C	--	67980050(+)	`CTCTCA/GTCTGC`	5	--	int¹		1		EU	1323
rs116185138^1,2	C,F	--	67980089(+)	`CGCAGC/GAGGAA`	10	L	syn¹		2		WA NA	4670
rs142605989^1,2	C	--	67980162(+)	`GGTAGC/TGCTCG`	10	H R	mis¹		1		NA	4552
rs113758909^1,2	C,F	--	67980268(+)	`CTGACG/CACCAG`	5	--	int¹		2		CSA	6
rs200924017^1,2		--	67980323(+)	`CCAGGC/TCCCAG`	5	--	int¹		0	--	--	--	--
rs200229449^1,2		--	67980373(+)	`CCTCGC/TTCTGT`	10	N S	mis¹		0	--	--	--	--
rs143852396^1,2	C	--	67980401(+)	`GCCCAG/ACACCA`	10	/L	syn¹		1		NA	4522
rs201320680^1,2		--	67980456(+)	`TGGGCC/TAGCCC`	10	L	syn¹		0	--	--	--	--
rs117639598^1,2	C	--	67980911(+)	`GGTCAG/AGCCCT`	10	/L	syn¹		1		EA	120
rs200615931^1,2		--	67980945(+)	`AAGGTA/GAGGAG`	10	L	syn¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC12A4 (67977377 - 68003504 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC12A4: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SLC12A4 for disorders           About GeneDecksing

OMIM gene information: 604119    OMIM disorders: --

8 diseases for SLC12A4:    About MalaCards

sickle cell disease hermaphroditism endometrial cancer cervical cancer

cervicitis ovarian cancer cholesterol neuronitis

1 Novoseek disease relationship for SLC12A4 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sickle cell disease	53.1	2	14976052 (1), 10564083 (1)

Human Genome Epidemiology (HuGE) Navigator: SLC12A4 (4 documents)

Export disorders for SLC12A4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC12A4 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with SLC12A4)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. (PubMed id 8663127)^{1, 2, 3, 9} Gillen C.M.... Forbush B. III (1996)
Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. (PubMed id 10564083)^{1, 2, 9} Su W.... Alper S.L. (1999)
Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. (PubMed id 9516379)^{1, 2, 9} Pellegrino C.M.... Schwartz R.S. (1998)
Similar Effects of all WNK3 Variants upon SLC12 Cotransporters. (PubMed id 21613606)^{1, 2} Cruz-Rangel S.... Mercado A. (2011)
The role of potassium chloride cotransporters in muri ne and human sperm volume regulation. (PubMed id 16943364)^{1, 7} Klein T....Yeung C.H. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. (PubMed id 11551954)^{1, 2} Casula S.... Alper S.L. (2001)
Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element. (PubMed id 14976052)^{1, 9} Zhou G.P....Gallagher P.G. (2004)
The up-regulation of KCC1 gene expression in cervical cancer cells by IGF-II through the ERK1/2MAPK and PI3K/AKT pathways and its significance. (PubMed id 19317253)^{1, 9} Zhang S....Sun X. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6560	HGNC: 10913	AceView: LCATandSLC12A4	Ensembl:ENSG00000124067	euGenes: HUgn6560
ECgene: SLC12A4	H-InvDB: SLC12A4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SLC12A4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC12A4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SLC12A4 gene:
Search GeneIP for patents involving SLC12A4

GeneCards and IP:
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