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Aliases for SLC11A1 Gene

Aliases for SLC11A1 Gene

  • Solute Carrier Family 11 Member 1 2 3 4 5
  • Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporter), Member 1 2 3
  • Natural Resistance-Associated Macrophage Protein 1 2 3
  • NRAMP 1 3 4
  • NRAMP1 3 4
  • NRAMP 3 4
  • LSH 3 4
  • Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 3
  • Solute Carrier Family 11 (Sodium/Phosphate Symporters), Member 1 3

External Ids for SLC11A1 Gene

Previous HGNC Symbols for SLC11A1 Gene

  • LSH
  • NRAMP
  • NRAMP1

Previous GeneCards Identifiers for SLC11A1 Gene

  • GC02P217262
  • GC02P217968
  • GC02P219210
  • GC02P219450
  • GC02P219449
  • GC02P219072
  • GC02P218955
  • GC02P219246
  • GC02P211100

Summaries for SLC11A1 Gene

Entrez Gene Summary for SLC11A1 Gene

  • This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC11A1 Gene

SLC11A1 (Solute Carrier Family 11 Member 1) is a Protein Coding gene. Diseases associated with SLC11A1 include Buruli Ulcer and Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included. Among its related pathways are Validated targets of C-MYC transcriptional repression and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and manganese ion transmembrane transporter activity. An important paralog of this gene is SLC11A2.

UniProtKB/Swiss-Prot for SLC11A1 Gene

  • Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Gene Wiki entry for SLC11A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC11A1 Gene

Genomics for SLC11A1 Gene

Regulatory Elements for SLC11A1 Gene

Enhancers for SLC11A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G218730 2.1 FANTOM5 Ensembl ENCODE dbSUPER 37.7 +350.9 350924 4.6 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SLC11A1 CYP27A1 PLCD4 USP37 NHEJ1 RNF25 ZNF142 BCS1L AAMP PNKD
GH02G218366 1.6 FANTOM5 ENCODE dbSUPER 47.5 -11.9 -11891 6.8 HDGF ATF1 CREB3L1 SIN3A YY1 ETS1 ZNF143 ZNF207 ZNF263 PAF1 SLC11A1 ENSG00000261338 ARPC2 CXCR2 CXCR1 CATIP PNKD CNOT9 TMBIM1 USP37
GH02G218281 2 FANTOM5 Ensembl ENCODE dbSUPER 21.3 -91.5 -91528 17.9 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000261338 SLC11A1 USP37 CTDSP1 MIR26B ARPC2 PNKD TMBIM1 CATIP-AS1 GPBAR1
GH02G217926 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.8 -449.1 -449071 12.6 HDAC1 SIN3A FEZF1 RAD21 RARA YY1 ZNF335 GATA2 FOS CEBPB SLC11A1 LOC105373878 TNS1 PNKD ARPC2 TMBIM1 GC02P217941 MIR6809
GH02G217897 2 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -479.3 -479263 9.9 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SLC11A1 LOC105373878 TNS1 RUFY4 PNKD ARPC2 TMBIM1 MIR6809 GC02P217941
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC11A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC11A1 Gene

Chromosome:
2
Start:
218,381,766 bp from pter
End:
218,396,894 bp from pter
Size:
15,129 bases
Orientation:
Plus strand

Genomic View for SLC11A1 Gene

Genes around SLC11A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC11A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC11A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC11A1 Gene

Proteins for SLC11A1 Gene

  • Protein details for SLC11A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49279-NRAM1_HUMAN
    Recommended name:
    Natural resistance-associated macrophage protein 1
    Protein Accession:
    P49279
    Secondary Accessions:
    • C0H5Y3

    Protein attributes for SLC11A1 Gene

    Size:
    550 amino acids
    Molecular mass:
    59872 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC11A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC11A1 Gene

Post-translational modifications for SLC11A1 Gene

  • Glycosylation at isoforms=2324 and Asn338
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC11A1 Gene

Domains & Families for SLC11A1 Gene

Gene Families for SLC11A1 Gene

Protein Domains for SLC11A1 Gene

Graphical View of Domain Structure for InterPro Entry

P49279

UniProtKB/Swiss-Prot:

NRAM1_HUMAN :
  • Belongs to the NRAMP family.
Family:
  • Belongs to the NRAMP family.
genes like me logo Genes that share domains with SLC11A1: view

Function for SLC11A1 Gene

Molecular function for SLC11A1 Gene

GENATLAS Biochemistry:
solute carrier family 11,member A1,proton-coupled divalent metal ion transporter family,natural resistance-associated macrophage protein 1,also expressed in liver,spleen with a polymorphism in the promoter region correlating with autoimmune versus infectious disease susceptibility
UniProtKB/Swiss-Prot Function:
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
UniProtKB/Swiss-Prot Induction:
In response to lymphokine or bacterial products.

Gene Ontology (GO) - Molecular Function for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005215 transporter activity IEA --
GO:0005384 manganese ion transmembrane transporter activity ISS --
GO:0042803 protein homodimerization activity IDA 8537108
GO:0046915 transition metal ion transmembrane transporter activity IGI 17932044
genes like me logo Genes that share ontologies with SLC11A1: view
genes like me logo Genes that share phenotypes with SLC11A1: view

Human Phenotype Ontology for SLC11A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC11A1 Gene

MGI Knock Outs for SLC11A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC11A1 Gene

Localization for SLC11A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC11A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC11A1 gene
Compartment Confidence
plasma membrane 5
endosome 5
lysosome 4
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005764 lysosome ISS --
GO:0005770 late endosome ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 8537108
genes like me logo Genes that share ontologies with SLC11A1: view

Pathways & Interactions for SLC11A1 Gene

genes like me logo Genes that share pathways with SLC11A1: view

Pathways by source for SLC11A1 Gene

Gene Ontology (GO) - Biological Process for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production ISS --
GO:0001819 positive regulation of cytokine production ISS --
GO:0002309 T cell proliferation involved in immune response ISS --
GO:0002369 T cell cytokine production ISS --
GO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS --
genes like me logo Genes that share ontologies with SLC11A1: view

No data available for SIGNOR curated interactions for SLC11A1 Gene

Drugs & Compounds for SLC11A1 Gene

(9) Drugs for SLC11A1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 34

(7) Additional Compounds for SLC11A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with SLC11A1: view

Transcripts for SLC11A1 Gene

Unigene Clusters for SLC11A1 Gene

Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC11A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 16b · 16c ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for SLC11A1 Gene

GeneLoc Exon Structure for
SLC11A1
ECgene alternative splicing isoforms for
SLC11A1

Expression for SLC11A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC11A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC11A1 Gene

This gene is overexpressed in Whole Blood (x34.2).

Protein differential expression in normal tissues from HIPED for SLC11A1 Gene

This gene is overexpressed in Kidney (60.6) and Monocytes (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC11A1 Gene



Protein tissue co-expression partners for SLC11A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC11A1 Gene:

SLC11A1

SOURCE GeneReport for Unigene cluster for SLC11A1 Gene:

Hs.591607

mRNA Expression by UniProt/SwissProt for SLC11A1 Gene:

P49279-NRAM1_HUMAN
Tissue specificity: Macrophages; peripheral blood leukocytes, lung, spleen and liver.

Evidence on tissue expression from TISSUES for SLC11A1 Gene

  • Blood(4.8)
  • Spleen(4.5)
  • Lung(2.6)
  • Intestine(2.5)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with SLC11A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC11A1 Gene

Orthologs for SLC11A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC11A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC11A1 34
  • 99.64 (n)
NRAMP1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC11A1 34 35
  • 88.85 (n)
cow
(Bos Taurus)
Mammalia SLC11A1 34 35
  • 88.6 (n)
mouse
(Mus musculus)
Mammalia Slc11a1 34 16 35
  • 83.49 (n)
rat
(Rattus norvegicus)
Mammalia Slc11a1 34
  • 83.14 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC11A1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC11A1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC11A1 34 35
  • 74.35 (n)
lizard
(Anolis carolinensis)
Reptilia SLC11A1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc11a1 34
  • 69.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Mvl 36 35
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea smf-1 36 35
  • 53 (a)
smf-2 36 35
  • 52 (a)
smf-3 35
  • 49 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMF3 35
  • 29 (a)
ManyToMany
SMF2 35
  • 27 (a)
ManyToMany
SMF1 35
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRAMP4 34
  • 54.36 (n)
rice
(Oryza sativa)
Liliopsida Os03g0208500 34
  • 56.67 (n)
Species where no ortholog for SLC11A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC11A1 Gene

ENSEMBL:
Gene Tree for SLC11A1 (if available)
TreeFam:
Gene Tree for SLC11A1 (if available)

Paralogs for SLC11A1 Gene

Paralogs for SLC11A1 Gene

(2) SIMAP similar genes for SLC11A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC11A1: view

Variants for SLC11A1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC11A1 Gene

NRAM1_HUMAN-P49279
Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIM:610446].
NRAM1_HUMAN-P49279
Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIM:607948].

Sequence variations from dbSNP and Humsavar for SLC11A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs17235409 other 218,395,009(+) AAGAG(A/C/G)ACCAG nc-transcript-variant, reference, missense
rs1000189829 -- 218,390,065(+) ACACA(C/T)GTACT intron-variant
rs1000204732 -- 218,390,444(+) GGAAC(A/T)AGCCA intron-variant
rs1000331553 -- 218,395,095(+) ATGTG(C/G)AGGGG nc-transcript-variant, utr-variant-3-prime
rs1000448969 -- 218,388,048(+) GCTCC(C/T)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC11A1 Gene

Variant ID Type Subtype PubMed ID
nsv3166 CNV insertion 18451855
nsv519829 CNV loss 19592680

Variation tolerance for SLC11A1 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.14; 61.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC11A1 Gene

Human Gene Mutation Database (HGMD)
SLC11A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC11A1

Disorders for SLC11A1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for SLC11A1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC11A1

Genetic Association Database (GAD)
SLC11A1
Human Genome Epidemiology (HuGE) Navigator
SLC11A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC11A1
genes like me logo Genes that share disorders with SLC11A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC11A1 Gene

Publications for SLC11A1 Gene

  1. Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism. (PMID: 16395392) Stienstra Y. … van der Steege G. (Genes Immun. 2006) 3 4 22 46 64
  2. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. (PMID: 16103355) Malik S. … Schurr E. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 46 64
  3. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. (PMID: 7964458) Cellier M. … Gros P. (J. Exp. Med. 1994) 2 3 4 22 64
  4. SLC11A1 (Formerly NRAMP1) gene polymorphisms associated with pediatric tuberculosis in China. (PMID: 19193106) Jin J. … Shen A. (Clin. Infect. Dis. 2009) 3 22 46 64
  5. Genetic susceptibility to BehAset's syndrome is associated with NRAMP1 (SLC11A1) polymorphism in Turkish patients. (PMID: 18998137) AteA9 O. … Topal-Sarikaya A. (Rheumatol. Int. 2009) 3 22 46 64

Products for SLC11A1 Gene

Sources for SLC11A1 Gene

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