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Aliases for SLC11A1 Gene

Aliases for SLC11A1 Gene

  • Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporter), Member 1 2 3
  • NRAMP1 3 4 6
  • Natural Resistance-Associated Macrophage Protein 1 2 3
  • Solute Carrier Family 11 Member 1 3 4
  • NRAMP 1 3 4
  • NRAMP 3 4
  • LSH 3 4
  • Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 3
  • Solute Carrier Family 11 (Sodium/Phosphate Symporters), Member 1 3
  • NRAMP, 6

External Ids for SLC11A1 Gene

Previous HGNC Symbols for SLC11A1 Gene

  • LSH
  • NRAMP
  • NRAMP1

Previous GeneCards Identifiers for SLC11A1 Gene

  • GC02P217262
  • GC02P217968
  • GC02P219210
  • GC02P219450
  • GC02P219449
  • GC02P219072
  • GC02P218955
  • GC02P219246
  • GC02P211100

Summaries for SLC11A1 Gene

Entrez Gene Summary for SLC11A1 Gene

  • This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC11A1 Gene

SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC11A1 include buruli ulcer and pulmonary tuberculosis. Among its related pathways are Disease and Lysosome. GO annotations related to this gene include protein homodimerization activity and transition metal ion transmembrane transporter activity. An important paralog of this gene is SLC11A2.

UniProtKB/Swiss-Prot for SLC11A1 Gene

  • Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes

Gene Wiki entry for SLC11A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC11A1 Gene

Genomics for SLC11A1 Gene

Regulatory Elements for SLC11A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC11A1 Gene

Start:
218,382,029 bp from pter
End:
218,396,894 bp from pter
Size:
14,866 bases
Orientation:
Plus strand

Genomic View for SLC11A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC11A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC11A1 Gene

Proteins for SLC11A1 Gene

  • Protein details for SLC11A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49279-NRAM1_HUMAN
    Recommended name:
    Natural resistance-associated macrophage protein 1
    Protein Accession:
    P49279
    Secondary Accessions:
    • C0H5Y3

    Protein attributes for SLC11A1 Gene

    Size:
    550 amino acids
    Molecular mass:
    59872 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC11A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC11A1 Gene

Proteomics data for SLC11A1 Gene at MOPED

Post-translational modifications for SLC11A1 Gene

  • Glycosylation at Asn324 and Asn338
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC11A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SLC11A1 (NRAMP1/SLC11A1)

No data available for DME Specific Peptides for SLC11A1 Gene

Domains for SLC11A1 Gene

Gene Families for SLC11A1 Gene

Protein Domains for SLC11A1 Gene

Graphical View of Domain Structure for InterPro Entry

P49279

UniProtKB/Swiss-Prot:

NRAM1_HUMAN :
  • P49279
Family:
  • Belongs to the NRAMP family.
genes like me logo Genes that share domains with SLC11A1: view

Function for SLC11A1 Gene

Molecular function for SLC11A1 Gene

GENATLAS Biochemistry: solute carrier family 11,member A1,proton-coupled divalent metal ion transporter family,natural resistance-associated macrophage protein 1,also expressed in liver,spleen with a polymorphism in the promoter region correlating with autoimmune versus infectious disease susceptibility
UniProtKB/Swiss-Prot Function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes
UniProtKB/Swiss-Prot Induction: In response to lymphokine or bacterial products

Gene Ontology (GO) - Molecular Function for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0005215 transporter activity --
GO:0005384 manganese ion transmembrane transporter activity ISS --
GO:0042803 protein homodimerization activity IDA 8537108
GO:0046915 transition metal ion transmembrane transporter activity IGI 17932044
genes like me logo Genes that share ontologies with SLC11A1: view
genes like me logo Genes that share phenotypes with SLC11A1: view

Animal Models for SLC11A1 Gene

MGI Knock Outs for SLC11A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC11A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC11A1 Gene

Localization for SLC11A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC11A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC11A1 Gene COMPARTMENTS Subcellular localization image for SLC11A1 gene
Compartment Confidence
plasma membrane 5
endosome 4
lysosome 3
vacuole 3

Gene Ontology (GO) - Cellular Components for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component --
GO:0005764 lysosome ISS --
GO:0005770 late endosome ISS --
GO:0005886 plasma membrane IMP 17932044
GO:0005887 integral component of plasma membrane NAS 8537108
genes like me logo Genes that share ontologies with SLC11A1: view

Pathways for SLC11A1 Gene

genes like me logo Genes that share pathways with SLC11A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
    • Th1/Th2 Response in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for SLC11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IEA --
GO:0001818 negative regulation of cytokine production ISS --
GO:0001819 positive regulation of cytokine production ISS --
GO:0002309 T cell proliferation involved in immune response ISS --
GO:0002369 T cell cytokine production ISS --
genes like me logo Genes that share ontologies with SLC11A1: view

Compounds for SLC11A1 Gene

(2) HMDB Compounds for SLC11A1 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
Manganese
  • manganese
7439-96-5

(16) Novoseek inferred chemical compound relationships for SLC11A1 Gene

Compound -log(P) Hits PubMed IDs
tgtg 93.5 7
lepromin 56.3 2
iron 54.5 53
vitamin d 42.8 10
manganese 30.8 3
genes like me logo Genes that share compounds with SLC11A1: view

Transcripts for SLC11A1 Gene

Unigene Clusters for SLC11A1 Gene

Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC11A1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC11A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC11A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 16b · 16c ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:

Relevant External Links for SLC11A1 Gene

GeneLoc Exon Structure for
SLC11A1
ECgene alternative splicing isoforms for
SLC11A1

Expression for SLC11A1 Gene

mRNA expression in normal human tissues for SLC11A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC11A1 Gene

This gene is overexpressed in Whole Blood (34.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC11A1 Gene

SOURCE GeneReport for Unigene cluster for SLC11A1 Gene Hs.591607

mRNA Expression by UniProt/SwissProt for SLC11A1 Gene

P49279-NRAM1_HUMAN
Tissue specificity: Macrophages; peripheral blood leukocytes, lung, spleen and liver
genes like me logo Genes that share expressions with SLC11A1: view

In Situ Assay Products

Orthologs for SLC11A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC11A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRAMP1 36
  • 99 (a)
OneToOne
SLC11A1 35
  • 99.64 (n)
  • 99.45 (a)
cow
(Bos Taurus)
Mammalia SLC11A1 35
  • 88.6 (n)
  • 89.58 (a)
SLC11A1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC11A1 35
  • 88.85 (n)
  • 88.3 (a)
SLC11A1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc11a1 35
  • 83.49 (n)
  • 87.66 (a)
Slc11a1 16
Slc11a1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC11A1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC11A1 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc11a1 35
  • 83.14 (n)
  • 86.76 (a)
chicken
(Gallus gallus)
Aves SLC11A1 35
  • 74.35 (n)
  • 72.96 (a)
SLC11A1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC11A1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc11a1 35
  • 69.11 (n)
  • 68.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mvl 36
  • 49 (a)
OneToMany
Mvl 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea smf-1 36
  • 46 (a)
ManyToMany
smf-2 36
  • 48 (a)
ManyToMany
smf-3 36
  • 49 (a)
ManyToMany
smf-1 37
  • 53 (a)
smf-2 37
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SMF1 36
  • 25 (a)
ManyToMany
SMF2 36
  • 27 (a)
ManyToMany
SMF3 36
  • 29 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NRAMP4 35
  • 54.36 (n)
  • 55.4 (a)
rice
(Oryza sativa)
Liliopsida Os03g0208500 35
  • 56.67 (n)
  • 54.68 (a)
Species with no ortholog for SLC11A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC11A1 Gene

ENSEMBL:
Gene Tree for SLC11A1 (if available)
TreeFam:
Gene Tree for SLC11A1 (if available)

Paralogs for SLC11A1 Gene

Paralogs for SLC11A1 Gene

Selected SIMAP similar genes for SLC11A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC11A1: view

Variants for SLC11A1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC11A1 Gene

P49279-NRAM1_HUMAN
Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIM:610446]

Sequence variations from dbSNP and Humsavar for SLC11A1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13062 -- 218,395,928(+) TAAAA(A/C/G/T)GGCGG utr-variant-3-prime, nc-transcript-variant
rs1059823 -- 218,395,121(+) AGGAT(A/G)GAGTG utr-variant-3-prime, nc-transcript-variant
rs1059824 -- 218,395,237(+) gagaC(A/G)CCACC utr-variant-3-prime, nc-transcript-variant
rs2045433 -- 218,392,965(-) GGTGA(A/G)CTCCT intron-variant, nc-transcript-variant
rs2276631 -- 218,384,290(-) ATGAG(A/G)AAGCC reference, synonymous-codon, utr-variant-5-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC11A1 Gene

Variant ID Type Subtype PubMed ID
nsv519829 CNV Loss 19592680
nsv875855 CNV Loss 21882294
nsv3166 CNV Insertion 18451855
dgv4435n71 CNV Loss 21882294
nsv875858 CNV Loss 21882294

Relevant External Links for SLC11A1 Gene

HapMap Linkage Disequilibrium report
SLC11A1
Human Gene Mutation Database (HGMD)
SLC11A1

Disorders for SLC11A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (21) Diseases for SLC11A1 Gene including...

Search for SLC11A1 Gene in MalaCards »

(2) OMIM Diseases for SLC11A1 Gene (600266)

(4) University of Copenhagen DISEASES for SLC11A1 Gene

(35) Novoseek inferred disease relationships for SLC11A1 Gene

Disease -log(P) Hits PubMed IDs
tuberculosis 73.1 115
genetic susceptibility 62 8
tuberculosis pulmonary 57.3 24
mycobacterial infection 56.2 3
infectious disease 55.2 13

Relevant External Links for SLC11A1

Genetic Association Database (GAD)
SLC11A1
Human Genome Epidemiology (HuGE) Navigator
SLC11A1
genes like me logo Genes that share disorders with SLC11A1: view

No data available for UniProtKB/Swiss-Prot for SLC11A1 Gene

Publications for SLC11A1 Gene

  1. Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. (PMID: 7964458) Cellier M. … Gros P. (J. Exp. Med. 1994) 2 3 4 23
  2. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. (PMID: 16103355) Malik S. … Schurr E. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23 48
  3. Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism. (PMID: 16395392) Stienstra Y. … van der Steege G. (Genes Immun. 2006) 3 4 23 48
  4. Global distribution of a novel trinucleotide microsatellite polymorphism (ATA)n in intron 8 of the SLC11A1 gene and susceptibility to pulmonary tuberculosis. (PMID: 16426236) Awomoyi A. … Tishkoff S. (Int. J. Immunogenet. 2006) 3 23 48
  5. Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population. (PMID: 16461017) Taype C.A. … Espinoza J.R. (Infect. Genet. Evol. 2006) 3 23 48

Products for SLC11A1 Gene

Sources for SLC11A1 Gene

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