SLC10A7 Gene
protein-coding GIFtS: 51
GCID: GC04M147175
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solute carrier family 10 (sodium/bile acid cotransporter...(Previous name: chromosome 4 open reading frame 13 )
(Previous symbol: C4orf13)
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Aliases
for SLC10A7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member71 2 | | DKFZp566M1141 | | C4orf131 2 3 | | DKFZp779O24381 | | Solute Carrier Family 10 Member 72 3 | | MGC250431 | | P72 3 | | Chromosome 4 Open Reading Frame 131 | | Na(+)/Bile Acid Cotransporter 72 3 | | SBF-Domain Containing Protein2 | | DKFZp313H05311 | | Sodium/Bile Acid Cotransporter 72 |
Export aliases for SLC10A7 gene to outside databasesPrevious GC identifers: GC04M147396 GC04M142895 |
Summaries
for SLC10A7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for SLC10A7
|
Genomic Views
for SLC10A7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC10A7 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx2-2 POU3F1 Nkx3-1 v1 HNF-3beta Nkx3-1 v2 Nkx3-1 v3 ZID Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC10A7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q31.22 Ensembl cytogenetic band: 4q31.22 HGNC cytogenetic band: 4q31.2SLC10A7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M147175: view genomic region
(about GC identifiers)
Start:
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147,175,127 bp from pter |
End:
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147,443,123 bp from pter |
Size:
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267,997 bases |
Orientation:
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minus strand |
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Proteins
for SLC10A7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NTCP7_HUMAN, Q0GE19 (See
protein sequence)Recommended Name: Sodium/bile acid cotransporter 7 Size: 358 amino acids; 39485 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAC11571.1; Type=Erroneous initiation;
Secondary accessions: A7E2E6 A7MAX9 Q0VAP9 Q45NG1 Q45NG2 Q5H9S6 Q6P4E6 Q8IZ62 Q8NBP8 Q9H0M9Alternative splicing: 7 isoforms: Q0GE19-1 Q0GE19-2 Q0GE19-3 Q0GE19-4 Q0GE19-5 Q0GE19-6 Q0GE19-7 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC10A7: NX_Q0GE19
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q0GE19
SLC10A7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001025169.1 NP_115504.1
ENSEMBL proteins: ENSP00000411297 ENSP00000334594 ENSP00000421275 ENSP00000377623 ENSP00000421603 ENSP00000422577 ENSP00000377626 ENSP00000264986
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC10A7 for ontologies About GeneDecksing
SLC10A7 Antibody Products:
Assay Products for SLC10A7: |
Protein
Domains /
Families
for SLC10A7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC10A7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q0GE19ProtoNet protein and cluster: Q0GE19 1 Blocks protein family: IPB002657 Bile acid:sodium symporter
UniProtKB/Swiss-Prot: NTCP7_HUMAN, Q0GE19Similarity: Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family |
Function
for SLC10A7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SLC10A7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015293 | symporter activity |
IEA | -- |
SLC10A7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC10A7:
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Pathways & Interactions
for SLC10A7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC10A7
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/13 Interacting proteins for SLC10A7 (Q0GE193 ENSP000003345944) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006814 | sodium ion transport |
IEA | -- |
SLC10A7 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC10A7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC10A7
1 HMDB Compound for SLC10A7 About this table
Search CenterWatch for drugs/clinical trials and news about SLC10A7 / NTCP7
|
Transcripts
for SLC10A7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC10A7 gene (3 alternative transcripts): NM_001030316.1 NM_001029998.3 NM_032128.3 Unigene Cluster for SLC10A7: Solute carrier family 10 (sodium/bile acid cotransporter family), member 7 Hs.659209 [show with all ESTs]Unigene Representative Sequence: NM_00102999811 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432059(uc003ikr.2 uc010ioz.2 uc010ipa.2 uc003iks.2)
ENST00000335472 ENST00000507030 ENST00000507560 ENST00000394059(uc003ikt.3)
ENST00000511315 ENST00000511374 ENST00000513583 ENST00000502607(uc003iku.4)
ENST00000394062 ENST00000264986
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC10A7 (NM_001029998) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC10A7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A7 |
Additional cDNA sequence: AK075364.1 AK126000.1 AK172727.1 AK291046.1 AL136728.1 AY346324.1 BC023288.1 BC063471.1 BC120970.1 BC120971.1 BC127626.1 BC127627.1 BC148252.1 BC150308.1 CR933647.1 CR936751.1 DQ122860.1 DQ871036.1 8 DOTS entries: DT.86840720 DT.100749004 DT.121228207 DT.91948153 DT.99936796 DT.121228285 DT.95161723 DT.121228290 24/49 AceView cDNA sequences (see all 49): BX091165 AK126000 BC023288 BE048810 BX280286 AL599929 AI351026 BU784904 BI917106 AI261734 AK075364 AK172727 CF122191 BM016458 BU681227 BF205167 AA251443 NM_032128 AL136728 BU785161 BG253997 BQ771787 BI767886 AI572409
GeneLoc Exon Structure
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Expression
for SLC10A7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC10A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTCTTA
About this image
See SLC10A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC10A7
SOURCE GeneReport for Unigene cluster: Hs.659209
SABiosciences Custom PCR Arrays for SLC10A7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC10A7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A7 |
Orthologs
for SLC10A7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SLC10A7 gene from 9/23 species (see all 23) About this table
ENSEMBL Gene Tree for SLC10A7 (if available)
TreeFam Gene Tree for SLC10A7 (if available) |
Paralogs
for SLC10A7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLC10A7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for SLC10A7
7 CNVs: 68822 59173 80507 36206 63979 98914 23707
3 Indels: 98913 92444 62271 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A7 |
|
Disorders
/ Diseases
for SLC10A7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC10A7 for disorders About GeneDecksing
OMIM gene information: 611459
OMIM disorders: --
1  disease for SLC10A7: About MalaCardsazoospermia
Human Genome Epidemiology (HuGE) Navigator: SLC10A7 (1 document)
Export disorders for SLC10A7 gene to outside databases
|
Publications
for SLC10A7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC10A7 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SLC10A7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family. (PubMed id 15932064)1, 2, 3, 9 Zou X.... Mao Y. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. (PubMed id 17628207)1 Godoy J.R....Geyer J. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
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External Searches for SLC10A7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC10A7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC10A7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC10A7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC10A7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC10A7 gene:
Search GeneIP for patents involving SLC10A7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC10A7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC10A7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC10A7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC10A7 | | OriGene 3'-UTR Clone for SLC10A7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC10A7 | | OriGene Custom Protein Services for SLC10A7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC10A7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC10A7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A7 |
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| | | | Search Tocris compounds for SLC10A7 |
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 | | | SLC10A7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A7 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A7 |
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