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Aliases for SLC10A7 Gene

Aliases for SLC10A7 Gene

  • Solute Carrier Family 10 Member 7 2 3 4 5
  • Na(+)/Bile Acid Cotransporter 7 3 4
  • C4orf13 3 4
  • P7 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 7 3
  • Chromosome 4 Open Reading Frame 13 2
  • Solute Carrier Family 10, Member 7 2
  • Sodium/Bile Acid Cotransporter 7 3
  • SBF-Domain Containing Protein 3

External Ids for SLC10A7 Gene

Previous HGNC Symbols for SLC10A7 Gene

  • C4orf13

Previous GeneCards Identifiers for SLC10A7 Gene

  • GC04M147396
  • GC04M147175
  • GC04M142895

Summaries for SLC10A7 Gene

GeneCards Summary for SLC10A7 Gene

SLC10A7 (Solute Carrier Family 10 Member 7) is a Protein Coding gene. GO annotations related to this gene include symporter activity.

Gene Wiki entry for SLC10A7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A7 Gene

Genomics for SLC10A7 Gene

Regulatory Elements for SLC10A7 Gene

Enhancers for SLC10A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G146519 1.1 ENCODE 10 +0.5 512 3.7 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 SLC10A7 MIR7849
GH04G146255 0.6 ENCODE 5.5 +265.9 265939 1.8 CTCF JUND JUN STAT3 CEBPB EP300 LOC345051 SLC10A7 ENSG00000251010 LOC105377472
GH04G146271 0.8 FANTOM5 1.2 +250.3 250345 0.3 TBL1XR1 BMI1 CEBPG EBF1 YY1 RELA EED ETV6 RELB IKZF2 ENSG00000251010 ZNF827 SLC10A7 LOC105377472
GH04G146511 0.6 Ensembl 0.4 +10.4 10371 0.4 ARID1B ETV1 ELF1 ETV6 NFE2 ZBTB40 SPI1 GABPA SLC10A7 MIR7849
GH04G146458 1 FANTOM5 ENCODE 0.2 +63.4 63424 1.0 TBP JUND NFYB JUNB FOS FOSL2 RELB RELA LSM6 MIR7849 SLC10A7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC10A7 on UCSC Golden Path with GeneCards custom track

Promoters for SLC10A7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174367 171 2801 PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for SLC10A7 Gene

Chromosome:
4
Start:
146,253,975 bp from pter
End:
146,521,971 bp from pter
Size:
267,997 bases
Orientation:
Minus strand

Genomic View for SLC10A7 Gene

Genes around SLC10A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A7 Gene

Proteins for SLC10A7 Gene

  • Protein details for SLC10A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0GE19-NTCP7_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter 7
    Protein Accession:
    Q0GE19
    Secondary Accessions:
    • A7E2E6
    • A7MAX9
    • Q0VAP9
    • Q45NG1
    • Q45NG2
    • Q5H9S6
    • Q6P4E6
    • Q8IZ62
    • Q8NBP8
    • Q9H0M9

    Protein attributes for SLC10A7 Gene

    Size:
    358 amino acids
    Molecular mass:
    39485 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC10A7 Gene

neXtProt entry for SLC10A7 Gene

Post-translational modifications for SLC10A7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC10A7 Gene

Domains & Families for SLC10A7 Gene

Gene Families for SLC10A7 Gene

Protein Domains for SLC10A7 Gene

Suggested Antigen Peptide Sequences for SLC10A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0GE19

UniProtKB/Swiss-Prot:

NTCP7_HUMAN :
  • Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family.
Family:
  • Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family.
genes like me logo Genes that share domains with SLC10A7: view

Function for SLC10A7 Gene

Gene Ontology (GO) - Molecular Function for SLC10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A7: view
genes like me logo Genes that share phenotypes with SLC10A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A7

CRISPR Products

miRNA for SLC10A7 Gene

miRTarBase miRNAs that target SLC10A7

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A7 Gene

Localization for SLC10A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A7 gene
Compartment Confidence
plasma membrane 4
nucleus 3

Gene Ontology (GO) - Cellular Components for SLC10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC10A7: view

Pathways & Interactions for SLC10A7 Gene

SuperPathways for SLC10A7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A7: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A7 Gene

Drugs & Compounds for SLC10A7 Gene

(1) Additional Compounds for SLC10A7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A7: view

Transcripts for SLC10A7 Gene

Unigene Clusters for SLC10A7 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A7 Gene

No ASD Table

Relevant External Links for SLC10A7 Gene

GeneLoc Exon Structure for
SLC10A7
ECgene alternative splicing isoforms for
SLC10A7

Expression for SLC10A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A7 Gene

Protein differential expression in normal tissues from HIPED for SLC10A7 Gene

This gene is overexpressed in Placenta (62.5) and Islet of Langerhans (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC10A7 Gene



Protein tissue co-expression partners for SLC10A7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC10A7 Gene:

SLC10A7

SOURCE GeneReport for Unigene cluster for SLC10A7 Gene:

Hs.659209

Evidence on tissue expression from TISSUES for SLC10A7 Gene

  • Kidney(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with SLC10A7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A7 Gene

Orthologs for SLC10A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC10A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC740545 34
  • 100 (n)
SLC10A7 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC10A7 34 35
  • 94.48 (n)
-- 35
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC10A7 34 35
  • 94.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A7 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a7 34 16 35
  • 87.35 (n)
rat
(Rattus norvegicus)
Mammalia Slc10a7 34
  • 86.86 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC10A7 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC10A7 34 35
  • 82.87 (n)
lizard
(Anolis carolinensis)
Reptilia SLC10A7 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a7 34
  • 79.43 (n)
Str.16755 34
African clawed frog
(Xenopus laevis)
Amphibia dkfzp566m114-prov 34
zebrafish
(Danio rerio)
Actinopterygii slc10a7 34 35
  • 70.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR085C 34
  • 44.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 20 (a)
OneToOne
RCH1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6964 35
  • 55 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8480 34
Species where no ortholog for SLC10A7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC10A7 Gene

ENSEMBL:
Gene Tree for SLC10A7 (if available)
TreeFam:
Gene Tree for SLC10A7 (if available)

Paralogs for SLC10A7 Gene

No data available for Paralogs for SLC10A7 Gene

Variants for SLC10A7 Gene

Sequence variations from dbSNP and Humsavar for SLC10A7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000014417 -- 146,443,686(+) CACTG(C/T)AGTAA intron-variant
rs1000022006 -- 146,513,648(+) CCATG(C/T)TGGCT intron-variant
rs1000023446 -- 146,345,385(+) ACTGG(C/T)CTTTA intron-variant
rs1000033531 -- 146,254,237(+) TGTAA(C/T)AACCA nc-transcript-variant, utr-variant-3-prime
rs1000034741 -- 146,514,048(+) TGGGA(A/C)GTAGA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC10A7 Gene

Variant ID Type Subtype PubMed ID
dgv3095e59 CNV duplication 20981092
esv1000928 CNV insertion 20482838
esv1004247 CNV deletion 20482838
esv1640176 CNV insertion 17803354
esv2438325 CNV insertion 19546169
esv2550267 CNV insertion 19546169
esv2661274 CNV deletion 23128226
esv2662568 CNV deletion 23128226
esv27195 CNV loss 19812545
esv2728494 CNV deletion 23290073
esv2728495 CNV deletion 23290073
esv28273 CNV gain 19812545
esv3305689 CNV mobile element insertion 20981092
esv3307055 CNV mobile element insertion 20981092
esv3326432 CNV insertion 20981092
esv3413916 CNV insertion 20981092
esv3431014 CNV duplication 20981092
esv3602576 CNV loss 21293372
esv3602577 CNV loss 21293372
esv3894049 CNV gain 25118596
esv8434 CNV loss 19470904
nsv1123853 CNV deletion 24896259
nsv428453 CNV gain 18775914
nsv4537 CNV insertion 18451855
nsv4538 CNV insertion 18451855
nsv461675 CNV gain 19166990
nsv509017 CNV insertion 20534489
nsv595651 CNV gain 21841781
nsv819040 CNV loss 19587683
nsv822765 CNV gain 20364138
nsv822766 CNV loss 20364138
nsv822767 CNV loss 20364138

Variation tolerance for SLC10A7 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC10A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A7 Gene

Disorders for SLC10A7 Gene

Relevant External Links for SLC10A7

Genetic Association Database (GAD)
SLC10A7
Human Genome Epidemiology (HuGE) Navigator
SLC10A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A7

No disorders were found for SLC10A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A7 Gene

Publications for SLC10A7 Gene

  1. Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family. (PMID: 15932064) Zou X. … Mao Y. (Biochem. Genet. 2005) 2 3 4 22 64
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SLC10A7 Gene

Sources for SLC10A7 Gene

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