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Aliases for SLC10A7 Gene

Aliases for SLC10A7 Gene

  • Solute Carrier Family 10 Member 7 2 3 4 5
  • Na(+)/Bile Acid Cotransporter 7 3 4
  • C4orf13 3 4
  • P7 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 7 3
  • Chromosome 4 Open Reading Frame 13 2
  • Solute Carrier Family 10, Member 7 2
  • Sodium/Bile Acid Cotransporter 7 3
  • SBF-Domain Containing Protein 3

External Ids for SLC10A7 Gene

Previous HGNC Symbols for SLC10A7 Gene

  • C4orf13

Previous GeneCards Identifiers for SLC10A7 Gene

  • GC04M147396
  • GC04M147175
  • GC04M142895

Summaries for SLC10A7 Gene

GeneCards Summary for SLC10A7 Gene

SLC10A7 (Solute Carrier Family 10 Member 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include symporter activity.

Gene Wiki entry for SLC10A7 Gene

Additional gene information for SLC10A7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A7 Gene

Genomics for SLC10A7 Gene

GeneHancer (GH) Regulatory Elements for SLC10A7 Gene

Promoters and enhancers for SLC10A7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I146519 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560 +0.5 511 3.7 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 GLI4 IRF4 ZNF48 YY1 SLC10A7 MIR7849
GH04I145934 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.3 +584.6 584577 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF827 GC04M145938 SLC10A7 LSM6 PIR42534
GH04I145812 Enhancer 1 ENCODE dbSUPER 12.2 +708.9 708913 1.6 PKNOX1 ZFP64 SIN3A BRCA1 RCOR1 FOS ZNF680 ZBTB11 CEBPB ZC3H11A OTUD4 ENSG00000248356 SLC10A7 ANAPC10 LSM6 ENSG00000279481 GC04M145759 ZNF827
GH04I145769 Enhancer 0.6 Ensembl 12.2 +752.1 752070 0.6 ZNF654 ZNF680 CEBPB ZNF140 ZC3H11A CEBPG REST ZNF623 ZNF781 ZNF697 OTUD4 ENSG00000248356 SLC10A7 LSM6 GC04M145759 ENSG00000279481 C4orf51 ZNF827
GH04I146255 Enhancer 0.5 ENCODE 5.5 +265.9 265939 1.8 SP1 JUND JUN STAT3 CEBPB FOSL2 EP300 REELD1 SLC10A7 ENSG00000251010 LOC105377472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC10A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC10A7 gene promoter:

Genomic Locations for SLC10A7 Gene

Genomic Locations for SLC10A7 Gene
267,997 bases
Minus strand

Genomic View for SLC10A7 Gene

Genes around SLC10A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A7 Gene

Proteins for SLC10A7 Gene

  • Protein details for SLC10A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/bile acid cotransporter 7
    Protein Accession:
    Secondary Accessions:
    • A7E2E6
    • A7MAX9
    • Q0VAP9
    • Q45NG1
    • Q45NG2
    • Q5H9S6
    • Q6P4E6
    • Q8IZ62
    • Q8NBP8
    • Q9H0M9

    Protein attributes for SLC10A7 Gene

    358 amino acids
    Molecular mass:
    39485 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11571.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC10A7 Gene

neXtProt entry for SLC10A7 Gene

Post-translational modifications for SLC10A7 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC10A7 Gene

Domains & Families for SLC10A7 Gene

Gene Families for SLC10A7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC10A7 Gene

Suggested Antigen Peptide Sequences for SLC10A7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family.
  • Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family.
genes like me logo Genes that share domains with SLC10A7: view

Function for SLC10A7 Gene

Phenotypes From GWAS Catalog for SLC10A7 Gene

Gene Ontology (GO) - Molecular Function for SLC10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A7: view
genes like me logo Genes that share phenotypes with SLC10A7: view

miRNA for SLC10A7 Gene

miRTarBase miRNAs that target SLC10A7

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A7 Gene

Localization for SLC10A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A7 gene
Compartment Confidence
plasma membrane 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC10A7: view

Pathways & Interactions for SLC10A7 Gene

SuperPathways for SLC10A7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A7: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A7 Gene

Drugs & Compounds for SLC10A7 Gene

(1) Additional Compounds for SLC10A7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC10A7: view

Transcripts for SLC10A7 Gene

Unigene Clusters for SLC10A7 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A7 Gene

No ASD Table

Relevant External Links for SLC10A7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC10A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A7 Gene

Protein differential expression in normal tissues from HIPED for SLC10A7 Gene

This gene is overexpressed in Placenta (62.5) and Islet of Langerhans (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC10A7 Gene

Protein tissue co-expression partners for SLC10A7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC10A7 Gene:


SOURCE GeneReport for Unigene cluster for SLC10A7 Gene:


Evidence on tissue expression from TISSUES for SLC10A7 Gene

  • Kidney(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with SLC10A7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A7 Gene

Orthologs for SLC10A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC10A7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC740545 33
  • 100 (n)
SLC10A7 34
  • 92 (a)
(Bos Taurus)
Mammalia SLC10A7 33 34
  • 94.48 (n)
-- 34
  • 90 (a)
(Canis familiaris)
Mammalia SLC10A7 33 34
  • 94.02 (n)
(Ornithorhynchus anatinus)
Mammalia SLC10A7 34
  • 93 (a)
(Mus musculus)
Mammalia Slc10a7 33 16 34
  • 87.35 (n)
(Rattus norvegicus)
Mammalia Slc10a7 33
  • 86.86 (n)
(Monodelphis domestica)
Mammalia SLC10A7 34
  • 79 (a)
(Gallus gallus)
Aves SLC10A7 33 34
  • 82.87 (n)
(Anolis carolinensis)
Reptilia SLC10A7 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a7 33
  • 79.43 (n)
Str.16755 33
African clawed frog
(Xenopus laevis)
Amphibia dkfzp566m114-prov 33
(Danio rerio)
Actinopterygii slc10a7 33 34
  • 70.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR085C 33
  • 44.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 20 (a)
RCH1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6964 34
  • 55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8480 33
Species where no ortholog for SLC10A7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC10A7 Gene

Gene Tree for SLC10A7 (if available)
Gene Tree for SLC10A7 (if available)

Paralogs for SLC10A7 Gene

No data available for Paralogs for SLC10A7 Gene

Variants for SLC10A7 Gene

Sequence variations from dbSNP and Humsavar for SLC10A7 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000014417 -- 146,443,686(-) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000022006 -- 146,513,648(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000023446 -- 146,345,385(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000033531 -- 146,254,237(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000034741 -- 146,514,048(-) C/A/T 3_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A7 Gene

Variant ID Type Subtype PubMed ID
dgv3095e59 CNV duplication 20981092
esv1000928 CNV insertion 20482838
esv1004247 CNV deletion 20482838
esv1640176 CNV insertion 17803354
esv2438325 CNV insertion 19546169
esv2550267 CNV insertion 19546169
esv2661274 CNV deletion 23128226
esv2662568 CNV deletion 23128226
esv27195 CNV loss 19812545
esv2728494 CNV deletion 23290073
esv2728495 CNV deletion 23290073
esv28273 CNV gain 19812545
esv3305689 CNV mobile element insertion 20981092
esv3307055 CNV mobile element insertion 20981092
esv3326432 CNV insertion 20981092
esv3413916 CNV insertion 20981092
esv3431014 CNV duplication 20981092
esv3602576 CNV loss 21293372
esv3602577 CNV loss 21293372
esv3894049 CNV gain 25118596
esv8434 CNV loss 19470904
nsv1123853 CNV deletion 24896259
nsv428453 CNV gain 18775914
nsv4537 CNV insertion 18451855
nsv4538 CNV insertion 18451855
nsv461675 CNV gain 19166990
nsv509017 CNV insertion 20534489
nsv595651 CNV gain 21841781
nsv819040 CNV loss 19587683
nsv822765 CNV gain 20364138
nsv822766 CNV loss 20364138
nsv822767 CNV loss 20364138

Variation tolerance for SLC10A7 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC10A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A7 Gene

Disorders for SLC10A7 Gene

Additional Disease Information for SLC10A7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC10A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A7 Gene

Publications for SLC10A7 Gene

  1. Molecular cloning and characterization of a novel human C4orf13 gene, tentatively a member of the sodium bile acid cotransporter family. (PMID: 15932064) Zou X … Mao Y (Biochemical genetics 2005) 2 3 4 22 58
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SLC10A7 Gene

Sources for SLC10A7 Gene

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