SLC10A6 Gene
protein-coding GIFtS: 44
GCID: GC04M087744
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solute carrier family 10 (sodium/bile acid cotransporter...
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Aliases
for SLC10A6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member61 2 | | SOAT1 2 3 5 | | Sodium-Dependent Organic Anion Transporter2 3 | | Solute Carrier Family 10 Member 62 |
Export aliases for SLC10A6 gene to outside databasesPrevious GC identifers: GC04M088103 GC04M087963 GC04M083489 |
Summaries
for SLC10A6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5Function: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugatedpyrenes in a sodium-dependent manner
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Genomic Views
for SLC10A6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC10A6 gene promoter:
AP-2rep p53 Pax-5 ATF-2 Lmo2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Evi-1 CRE-BP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC10A6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.3 Ensembl cytogenetic band: 4q21.3 HGNC cytogenetic band: 4q22.1SLC10A6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M087744: view genomic region
(about GC identifiers)
Start:
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87,744,621 bp from pter |
End:
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87,770,416 bp from pter |
Size:
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25,796 bases |
Orientation:
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minus strand |
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Proteins
for SLC10A6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5 (See
protein sequence)Recommended Name: Solute carrier family 10 member 6 Size: 377 amino acids; 41259 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q70EX7Explore the universe of human proteins at neXtProt for SLC10A6: NX_Q3KNW5
Post-translational modifications:
Glycosylated1
View neXtProt modification sites for NX_Q3KNW5
SLC10A6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_932069.1
ENSEMBL proteins: ENSP00000273905 ENSP00000421022 Reactome Protein details: Q3KNW5
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC10A6 for ontologies About GeneDecksing
SLC10A6 Antibody Products:
Assay Products for SLC10A6: |
Protein
Domains /
Families
for SLC10A6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC10A6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3KNW5ProtoNet protein and cluster: Q3KNW5 1 Blocks protein family: IPB002657 Bile acid:sodium symporter
UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family |
Function
for SLC10A6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5Function: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugatedpyrenes in a sodium-dependent manner
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for SLC10A6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008508 | bile acid:sodium symporter activity |
IEA | -- | | GO:0043250 | sodium-dependent organic anion transmembrane transporter activity |
IEA | -- |
SLC10A6 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC10A6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Bile salt and organic anion SLC transporters | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for SLC10A6
SLC10A6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC10A6
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0043251 | sodium-dependent organic anion transport |
IEA | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
SLC10A6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC10A6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC10A6
1 HMDB Compound for SLC10A6 About this table
Search CenterWatch for drugs/clinical trials and news about SLC10A6 / SOAT
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Transcripts
for SLC10A6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC10A6 gene: NM_197965.2 Unigene Cluster for SLC10A6: Solute carrier family 10 (sodium/bile acid cotransporter family), member 6 Hs.452996 Unigene Representative Sequence: NM_1979652 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000273905(uc003hqd.2) ENST00000505535
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC10A6 (NM_197965) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC10A6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A6 |
Additional cDNA sequence: AJ583502.1 BC107051.1 BC107052.1 EF437223.1 1 DOTS entry: DT.91814753 3 AceView cDNA sequences: NM_197965 AJ583502 BE181226
GeneLoc Exon Structure
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Expression
for SLC10A6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC10A6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGATTGTGA
About this image
See SLC10A6 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.452996
UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5Tissue specificity: Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammarygland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus
SABiosciences Custom PCR Arrays for SLC10A6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC10A6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A6 |
Orthologs
for SLC10A6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC10A6 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for SLC10A6 (if available)
TreeFam Gene Tree for SLC10A6 (if available) |
Paralogs
for SLC10A6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC10A6 gene
- SLC10A32 SLC10A12 SLC10A42 SLC10A22 SLC10A52
3 SIMAP similar genes for SLC10A6 using alignment to 2 protein entries: SOAT_HUMAN (see all proteins):SLC10A2 SLC10A1 SLC10A4
SLC10A6 for paralogs About GeneDecksing
|
Genomic Variants
for SLC10A6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A6 |
|
Disorders
/ Diseases
for SLC10A6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC10A6 for disorders About GeneDecksing
OMIM gene information: 613366
OMIM disorders: --
1  disease for SLC10A6: About MalaCardsprostatitis
Export disorders for SLC10A6 gene to outside databases
|
Publications
for SLC10A6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC10A6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC10A6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (PubMed id 17491011)1, 2, 3, 9 Geyer J.... Petzinger E. (2007)
- The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PubMed id 16541252)1, 9 Geyer J....Petzinger E. (2006)
- Genome-wide association study identifies novel loci as sociation with fasting insulin and insulin resistance in African Americans. (PubMed id 22791750)1 Chen G....Rotimi C. (2012)
- Identification of a sodium-dependent organic anion transporter from rat adrenal gland. (PubMed id 15020217)3 Geyer J....Petzinger E. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SLC10A6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC10A6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC10A6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC10A6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC10A6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC10A6 gene:
Search GeneIP for patents involving SLC10A6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC10A6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC10A6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC10A6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A6 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC10A6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | SLC10A6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A6 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC10A6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A6 |
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