Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC10A6 Gene

Aliases for SLC10A6 Gene

  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 6 2 3
  • SOAT 3 4 6
  • Sodium-Dependent Organic Anion Transporter 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 6 3
  • Solute Carrier Family 10 Member 6 3

External Ids for SLC10A6 Gene

Summaries for SLC10A6 Gene

GeneCards Summary for SLC10A6 Gene

SLC10A6 (Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 6) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. An important paralog of this gene is SLC10A5.

UniProtKB/Swiss-Prot for SLC10A6 Gene

  • Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A6 Gene

Genomics for SLC10A6 Gene

Genomic Location for SLC10A6 Gene

Start:
86,823,324 bp from pter
End:
86,849,263 bp from pter
Size:
25,940 bases
Orientation:
Minus strand

Genomic View for SLC10A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC10A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A6 Gene

Regulatory Elements for SLC10A6 Gene

Proteins for SLC10A6 Gene

  • Protein details for SLC10A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW5-SOAT_HUMAN
    Recommended name:
    Solute carrier family 10 member 6
    Protein Accession:
    Q3KNW5
    Secondary Accessions:
    • Q70EX7

    Protein attributes for SLC10A6 Gene

    Size:
    377 amino acids
    Molecular mass:
    41259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A6 Gene

Proteomics data for SLC10A6 Gene at MOPED

Post-translational modifications for SLC10A6 Gene

Other Protein References for SLC10A6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A6 Gene

Domains for SLC10A6 Gene

Gene Families for SLC10A6 Gene

Protein Domains for SLC10A6 Gene

UniProtKB/Swiss-Prot:

SOAT_HUMAN
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.:
    • Q3KNW5
genes like me logo Genes that share domains with SLC10A6: view

Function for SLC10A6 Gene

Molecular function for SLC10A6 Gene

UniProtKB/Swiss-Prot Function: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.

Gene Ontology (GO) - Molecular Function for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity IBA --
GO:0043250 sodium-dependent organic anion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC10A6 Gene

Localization for SLC10A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A6 Gene COMPARTMENTS Subcellular localization image for SLC10A6 gene
Compartment Confidence
plasma membrane 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC10A6: view

Pathways for SLC10A6 Gene

genes like me logo Genes that share pathways with SLC10A6: view

Interacting Proteins for SLC10A6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273905%0d%0a9606.ENSP00000254940%0d%0a
Selected Interacting proteins: ENSP00000273905 for SLC10A6 Gene via STRING

Symbol External ID(s) Details
NIP7

Gene Ontology (GO) - Biological Process for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport IBA --
GO:0043251 sodium-dependent organic anion transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC10A6: view

Compounds for SLC10A6 Gene

(1) HMDB Compounds for SLC10A6 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC10A6: view

Transcripts for SLC10A6 Gene

mRNA/cDNA for SLC10A6 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A6 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A6 Gene

No ASD Table

Relevant External Links for SLC10A6 Gene

GeneLoc Exon Structure for
SLC10A6
ECgene alternative splicing isoforms for
SLC10A6

Expression for SLC10A6 Gene

mRNA expression in normal human tissues for SLC10A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (9.9), Skin - Sun Exposed (Lower leg) (8.4), and Esophagus - Mucosa (5.2).

SOURCE GeneReport for Unigene cluster for SLC10A6 Gene Hs.452996

mRNA Expression by UniProt/SwissProt for SLC10A6 Gene

Q3KNW5-SOAT_HUMAN
Tissue specificity: Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.
genes like me logo Genes that share expressions with SLC10A6: view

Orthologs for SLC10A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A6 36
  • 99.47 (n)
  • 99.2 (a)
SLC10A6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC10A6 36
  • 83.64 (n)
  • 77.72 (a)
SLC10A6 37
  • 74 (a)
OneToMany
SLC10A6 37
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC10A6 36
  • 88.56 (n)
  • 86.44 (a)
SLC10A6 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a6 36
  • 78.46 (n)
  • 71.05 (a)
Slc10a6 16
Slc10a6 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC10A6 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A6 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc10a6 36
  • 77.03 (n)
  • 70.54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a6 36
  • 60.14 (n)
  • 55.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 37
  • 15 (a)
ManyToMany
CG9903 37
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToMany
Species with no ortholog for SLC10A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC10A6 Gene

ENSEMBL:
Gene Tree for SLC10A6 (if available)
TreeFam:
Gene Tree for SLC10A6 (if available)

Paralogs for SLC10A6 Gene

Paralogs for SLC10A6 Gene

Selected SIMAP similar genes for SLC10A6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC10A6: view

Variants for SLC10A6 Gene

Sequence variations from dbSNP and Humsavar for SLC10A6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1272664 -- 86,843,920(-) attac(A/C)ggtgt intron-variant
rs1420622 -- 86,826,229(+) AAAAA(C/T)GTATA intron-variant
rs2869619 -- 86,832,709(+) ATCTT(C/T)AGGAA intron-variant
rs4386565 -- 86,833,313(+) ATGTT(C/T)TGATA synonymous-codon, reference
rs4419446 -- 86,831,672(+) TGTAA(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A6 Gene

Variant ID Type Subtype PubMed ID
nsv830001 CNV Loss 17160897
esv2727934 CNV Deletion 23290073

Relevant External Links for SLC10A6 Gene

HapMap Linkage Disequilibrium report
SLC10A6

Disorders for SLC10A6 Gene

No disorders were found for SLC10A6 Gene.

No data available for UniProtKB/Swiss-Prot for SLC10A6 Gene

Publications for SLC10A6 Gene

  1. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (PMID: 17491011) Geyer J. … Petzinger E. (J. Biol. Chem. 2007) 2 3 4 23
  2. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J. … Petzinger E. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. (PMID: 22791750) Chen G. … Rotimi C. (Hum. Mol. Genet. 2012) 3
  5. Identification of a sodium-dependent organic anion transporter from rat adrenal gland. (PMID: 15020217) Geyer J. … Petzinger E. (Biochem. Biophys. Res. Commun. 2004) 2

Products for SLC10A6 Gene

Sources for SLC10A6 Gene

Back to Top

Content