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Aliases for SLC10A6 Gene

Aliases for SLC10A6 Gene

  • Solute Carrier Family 10 Member 6 2 3 5
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 6 2 3
  • Sodium-Dependent Organic Anion Transporter 3 4
  • SOAT 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 6 3

External Ids for SLC10A6 Gene

Previous GeneCards Identifiers for SLC10A6 Gene

  • GC04M088103
  • GC04M087963
  • GC04M087744
  • GC04M083489

Summaries for SLC10A6 Gene

GeneCards Summary for SLC10A6 Gene

SLC10A6 (Solute Carrier Family 10 Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. An important paralog of this gene is SLC10A2.

UniProtKB/Swiss-Prot for SLC10A6 Gene

  • Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.

Additional gene information for SLC10A6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A6 Gene

Genomics for SLC10A6 Gene

Regulatory Elements for SLC10A6 Gene

Enhancers for SLC10A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H086479 1.2 Ensembl ENCODE dbSUPER 10.4 +367.0 366954 5 CTCF PKNOX1 CBFB FEZF1 ZNF384 ZIC2 ETS1 ZNF664 POLR2A GLIS1 PTPN13 MAPK10 SLC10A6 HSD17B13 MIR4452 RN7SKP96
GH04H086844 0.9 FANTOM5 ENCODE dbSUPER 9.6 +3.7 3665 1 NR2F2 SLC10A6 AFF1 GC04P086697
GH04H087004 2 FANTOM5 Ensembl ENCODE dbSUPER 4.1 -161.1 -161094 11 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 AFF1 RPL6P13 C4orf36 AFF1-AS1 LOC100419572 LOC260422 MAPK10 HSD17B13 SLC10A6 GC04P087042
GH04H086496 0.7 ENCODE 10.6 +352.4 352440 1 SMARCE1 CTCF DPF2 RAD21 RFX5 GATA3 EED SCRT2 IKZF1 SMC3 PTPN13 MAPK10 SLC10A6 MIR4452 RN7SKP96
GH04H087024 1.4 Ensembl ENCODE dbSUPER 5 -177.2 -177229 3 PKNOX1 FOXA2 ARID4B ATF7 ETV6 RUNX3 CREM IKZF2 SMAD5 CBFB AFF1-AS1 C4orf36 AFF1 LOC260422 SLC10A6 GC04P087042 GC04P086967 PIR55151
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC10A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A6 Gene

Chromosome:
4
Start:
86,787,607 bp from pter
End:
86,849,360 bp from pter
Size:
61,754 bases
Orientation:
Minus strand

Genomic View for SLC10A6 Gene

Genes around SLC10A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A6 Gene

Proteins for SLC10A6 Gene

  • Protein details for SLC10A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW5-SOAT_HUMAN
    Recommended name:
    Solute carrier family 10 member 6
    Protein Accession:
    Q3KNW5
    Secondary Accessions:
    • Q70EX7

    Protein attributes for SLC10A6 Gene

    Size:
    377 amino acids
    Molecular mass:
    41259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A6 Gene

Post-translational modifications for SLC10A6 Gene

Other Protein References for SLC10A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A6 Gene

Domains & Families for SLC10A6 Gene

Gene Families for SLC10A6 Gene

Protein Domains for SLC10A6 Gene

Suggested Antigen Peptide Sequences for SLC10A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KNW5

UniProtKB/Swiss-Prot:

SOAT_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A6: view

Function for SLC10A6 Gene

Molecular function for SLC10A6 Gene

UniProtKB/Swiss-Prot Function:
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.

Phenotypes From GWAS Catalog for SLC10A6 Gene

Gene Ontology (GO) - Molecular Function for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity TAS --
GO:0015293 symporter activity IEA --
GO:0043250 sodium-dependent organic anion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A6: view
genes like me logo Genes that share phenotypes with SLC10A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A6

CRISPR Products

miRNA for SLC10A6 Gene

miRTarBase miRNAs that target SLC10A6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC10A6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A6 Gene

Localization for SLC10A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC10A6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC10A6 Gene

Pathways & Interactions for SLC10A6 Gene

genes like me logo Genes that share pathways with SLC10A6: view

Interacting Proteins for SLC10A6 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273905%0d%0a9606.ENSP00000306397%0d%0a9606.ENSP00000254940%0d%0a9606.ENSP00000316596%0d%0a
Selected Interacting proteins: ENSP00000273905 for SLC10A6 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport IEA --
GO:0043251 sodium-dependent organic anion transport IEA --
genes like me logo Genes that share ontologies with SLC10A6: view

No data available for SIGNOR curated interactions for SLC10A6 Gene

Drugs & Compounds for SLC10A6 Gene

(2) Drugs for SLC10A6 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pregnenolone Experimental Pharma Transporter 0
Prasterone sulfate Investigational Pharma Transporter 0

(1) Additional Compounds for SLC10A6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A6: view

Transcripts for SLC10A6 Gene

mRNA/cDNA for SLC10A6 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A6 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC10A6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A6 Gene

No ASD Table

Relevant External Links for SLC10A6 Gene

GeneLoc Exon Structure for
SLC10A6
ECgene alternative splicing isoforms for
SLC10A6

Expression for SLC10A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.9), Skin - Sun Exposed (Lower leg) (x8.4), and Esophagus - Mucosa (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of SLC10A6 Gene:

SLC10A6

SOURCE GeneReport for Unigene cluster for SLC10A6 Gene:

Hs.452996

mRNA Expression by UniProt/SwissProt for SLC10A6 Gene:

Q3KNW5-SOAT_HUMAN
Tissue specificity: Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.

Evidence on tissue expression from TISSUES for SLC10A6 Gene

  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with SLC10A6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A6 Gene

Orthologs for SLC10A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A6 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia SLC10A6 33 34
  • 88.56 (n)
cow
(Bos Taurus)
Mammalia SLC10A6 33 34 34
  • 83.64 (n)
mouse
(Mus musculus)
Mammalia Slc10a6 33 16 34
  • 78.46 (n)
rat
(Rattus norvegicus)
Mammalia Slc10a6 33
  • 77.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC10A6 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A6 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a6 33
  • 60.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 34
  • 15 (a)
ManyToMany
CG9903 34
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToMany
Species where no ortholog for SLC10A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC10A6 Gene

ENSEMBL:
Gene Tree for SLC10A6 (if available)
TreeFam:
Gene Tree for SLC10A6 (if available)

Paralogs for SLC10A6 Gene

Paralogs for SLC10A6 Gene

(3) SIMAP similar genes for SLC10A6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC10A6: view

Variants for SLC10A6 Gene

Sequence variations from dbSNP and Humsavar for SLC10A6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000077124 -- 86,836,617(+) TTTCT(C/T)TTCTC intron-variant
rs1000147274 -- 86,835,212(+) CCCCA(C/T)TGGAT intron-variant
rs1000178970 -- 86,834,892(+) GCAAG(A/G)GAGAG intron-variant
rs1000449434 -- 86,836,933(+) TTGTA(G/T)TTTTA intron-variant
rs1000479068 -- 86,836,744(+) GCAGA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A6 Gene

Variant ID Type Subtype PubMed ID
dgv1510e212 CNV loss 25503493
esv2727934 CNV deletion 23290073
esv3564194 CNV deletion 23714750
nsv1013308 CNV gain 25217958
nsv594787 CNV gain 21841781
nsv830001 CNV loss 17160897

Variation tolerance for SLC10A6 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC10A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A6 Gene

Disorders for SLC10A6 Gene

Relevant External Links for SLC10A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A6

No disorders were found for SLC10A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A6 Gene

Publications for SLC10A6 Gene

  1. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (PMID: 17491011) Geyer J … Petzinger E (The Journal of biological chemistry 2007) 2 3 4 22 60
  2. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J … Petzinger E (Naunyn-Schmiedeberg's archives of pharmacology 2006) 3 22 60
  3. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. (PMID: 22791750) Chen G … Rotimi C (Human molecular genetics 2012) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Identification of a sodium-dependent organic anion transporter from rat adrenal gland. (PMID: 15020217) Geyer J … Petzinger E (Biochemical and biophysical research communications 2004) 2 60

Products for SLC10A6 Gene

Sources for SLC10A6 Gene

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