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Aliases for SLC10A6 Gene

Aliases for SLC10A6 Gene

  • Solute Carrier Family 10 Member 6 2 3
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 6 2 3 5
  • Sodium-Dependent Organic Anion Transporter 3 4
  • SOAT 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 6 3

External Ids for SLC10A6 Gene

Previous GeneCards Identifiers for SLC10A6 Gene

  • GC04M088103
  • GC04M087963
  • GC04M087744
  • GC04M083489

Summaries for SLC10A6 Gene

GeneCards Summary for SLC10A6 Gene

SLC10A6 (Solute Carrier Family 10 Member 6) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. An important paralog of this gene is SLC10A2.

UniProtKB/Swiss-Prot for SLC10A6 Gene

  • Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A6 Gene

Genomics for SLC10A6 Gene

Regulatory Elements for SLC10A6 Gene

Enhancers for SLC10A6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC10A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC10A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC10A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A6 Gene

Chromosome:
4
Start:
86,787,607 bp from pter
End:
86,849,360 bp from pter
Size:
61,754 bases
Orientation:
Minus strand

Genomic View for SLC10A6 Gene

Genes around SLC10A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A6 Gene

Proteins for SLC10A6 Gene

  • Protein details for SLC10A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW5-SOAT_HUMAN
    Recommended name:
    Solute carrier family 10 member 6
    Protein Accession:
    Q3KNW5
    Secondary Accessions:
    • Q70EX7

    Protein attributes for SLC10A6 Gene

    Size:
    377 amino acids
    Molecular mass:
    41259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A6 Gene

Proteomics data for SLC10A6 Gene at MOPED

Post-translational modifications for SLC10A6 Gene

Other Protein References for SLC10A6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A6 Gene

Domains & Families for SLC10A6 Gene

Gene Families for SLC10A6 Gene

Protein Domains for SLC10A6 Gene

Suggested Antigen Peptide Sequences for SLC10A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KNW5

UniProtKB/Swiss-Prot:

SOAT_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A6: view

Function for SLC10A6 Gene

Molecular function for SLC10A6 Gene

UniProtKB/Swiss-Prot Function:
Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner.
genes like me logo Genes that share phenotypes with SLC10A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A6

CRISPR Products

miRNA for SLC10A6 Gene

miRTarBase miRNAs that target SLC10A6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A6 Gene

Localization for SLC10A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A6 Gene COMPARTMENTS Subcellular localization image for SLC10A6 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for SLC10A6 Gene

Pathways & Interactions for SLC10A6 Gene

genes like me logo Genes that share pathways with SLC10A6: view

Interacting Proteins for SLC10A6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273905%0d%0a9606.ENSP00000254940%0d%0a
Selected Interacting proteins: ENSP00000273905 for SLC10A6 Gene via STRING

Symbol External ID(s) Details
NIP7

Gene Ontology (GO) - Biological Process for SLC10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
GO:0043251 sodium-dependent organic anion transport IEA --
genes like me logo Genes that share ontologies with SLC10A6: view

No data available for SIGNOR curated interactions for SLC10A6 Gene

Drugs & Compounds for SLC10A6 Gene

(2) Drugs for SLC10A6 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pregnenolone Experimental Pharma Transporter 0
dehydroepiandrosterone sulfate Investigational Pharma Transporter 0

(1) Additional Compounds for SLC10A6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A6: view

Transcripts for SLC10A6 Gene

mRNA/cDNA for SLC10A6 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A6 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A6 Gene

No ASD Table

Relevant External Links for SLC10A6 Gene

GeneLoc Exon Structure for
SLC10A6
ECgene alternative splicing isoforms for
SLC10A6

Expression for SLC10A6 Gene

mRNA expression in normal human tissues for SLC10A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.9), Skin - Sun Exposed (Lower leg) (x8.4), and Esophagus - Mucosa (x5.2).

SOURCE GeneReport for Unigene cluster for SLC10A6 Gene Hs.452996

mRNA Expression by UniProt/SwissProt for SLC10A6 Gene

Q3KNW5-SOAT_HUMAN
Tissue specificity: Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and thymus.
genes like me logo Genes that share expression patterns with SLC10A6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC10A6 Gene

Orthologs for SLC10A6 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC10A6 35
  • 83.64 (n)
  • 77.72 (a)
SLC10A6 36
  • 74 (a)
OneToMany
SLC10A6 36
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC10A6 35
  • 88.56 (n)
  • 86.44 (a)
SLC10A6 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a6 35
  • 78.46 (n)
  • 71.05 (a)
Slc10a6 16
Slc10a6 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC10A6 35
  • 99.47 (n)
  • 99.2 (a)
SLC10A6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc10a6 35
  • 77.03 (n)
  • 70.54 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC10A6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A6 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a6 35
  • 60.14 (n)
  • 55.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 36
  • 15 (a)
ManyToMany
CG9903 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for SLC10A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC10A6 Gene

ENSEMBL:
Gene Tree for SLC10A6 (if available)
TreeFam:
Gene Tree for SLC10A6 (if available)

Paralogs for SLC10A6 Gene

Paralogs for SLC10A6 Gene

(3) SIMAP similar genes for SLC10A6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC10A6: view

Variants for SLC10A6 Gene

Sequence variations from dbSNP and Humsavar for SLC10A6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17694522 - 86,849,099(+) TGCTG(A/C/G)AACAA upstream-variant-2KB, reference, missense
rs13106574 - 86,848,776(+) GAAAA(C/T)GTTAG upstream-variant-2KB, reference, missense
rs1272664 -- 86,843,920(-) attac(A/C)ggtgt intron-variant
rs1420622 -- 86,826,229(+) AAAAA(C/T)GTATA intron-variant
rs1420623 -- 86,818,197(+) actca(A/G)ctttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A6 Gene

Variant ID Type Subtype PubMed ID
nsv830001 CNV Loss 17160897
esv2727934 CNV Deletion 23290073

Variation tolerance for SLC10A6 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.60; 72.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC10A6 Gene

Disorders for SLC10A6 Gene

Relevant External Links for SLC10A6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A6

No disorders were found for SLC10A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A6 Gene

Publications for SLC10A6 Gene

  1. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (PMID: 17491011) Geyer J. … Petzinger E. (J. Biol. Chem. 2007) 2 3 4 23 25 67
  2. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J. … Petzinger E. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 3 23
  3. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. (PMID: 22791750) Chen G. … Rotimi C. (Hum. Mol. Genet. 2012) 3
  4. Identification of a sodium-dependent organic anion transporter from rat adrenal gland. (PMID: 15020217) Geyer J. … Petzinger E. (Biochem. Biophys. Res. Commun. 2004) 2
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC10A6 Gene

Sources for SLC10A6 Gene

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