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SLC10A6 Gene

protein-coding   GIFtS: 47
GCID: GC04M087744

Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 61 2
SOAT2 3 5
Sodium-Dependent Organic Anion Transporter2 3
Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 62
Solute Carrier Family 10 Member 62

External Ids:    HGNC: 306031   Entrez Gene: 3452742   Ensembl: ENSG000001452837   OMIM: 6133665   UniProtKB: Q3KNW53   

Export aliases for SLC10A6 gene to outside databases

Previous GC identifers: GC04M088103 GC04M087963 GC04M083489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC10A6 Gene:
SLC10A6 (solute carrier family 10 (sodium/bile acid cotransporter), member 6) is a protein-coding gene. Diseases associated with SLC10A6 include insulin resistance, and prostatitis. GO annotations related to this gene include sodium-dependent organic anion transmembrane transporter activity and bile acid:sodium symporter activity. An important paralog of this gene is SLC10A3.

UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5
Function: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and
sulfoconjugated pyrenes in a sodium-dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC10A6 gene promoter:
         AP-2rep   p53   Pax-5   ATF-2   Lmo2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   CRE-BP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC10A6 promoter sequence
   Search Chromatin IP Primers for SLC10A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC10A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.3   Ensembl cytogenetic band:  4q21.3   HGNC cytogenetic band: 4q22.1

SLC10A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC10A6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M087744:  view genomic region     (about GC identifiers)

Start:
87,744,621 bp from pter      End:
87,770,416 bp from pter
Size:
25,796 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5 (See protein sequence)
Recommended Name: Solute carrier family 10 member 6  
Size: 377 amino acids; 41259 Da
Secondary accessions: Q70EX7

Explore the universe of human proteins at neXtProt for SLC10A6: NX_Q3KNW5

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn4, Asn157
  • REFSEQ proteins: NP_932069.1  
    ENSEMBL proteins: 
     ENSP00000273905  
    Reactome Protein details: Q3KNW5

    SLC10A6 Human Recombinant Protein Products:

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    SLC10A6 Assay Products:

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    Cloud-Clone Corp. CLIAs for SLC10A6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/bile acid cotransporter 6
    SLC10 family of sodium-bile acid co-transporters

    2 InterPro protein domains:
     IPR004710 Bil_ac_transpt
     IPR002657 BilAc/Na_symport

    Graphical View of Domain Structure for InterPro Entry Q3KNW5

    ProtoNet protein and cluster: Q3KNW5

    1 Blocks protein domain: IPB002657 Bile acid:sodium symporter

    UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5
    Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family


    SLC10A6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SOAT_HUMAN, Q3KNW5
    Function: Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and
    sulfoconjugated pyrenes in a sodium-dependent manner

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008508bile acid:sodium symporter activity IEA--
    GO:0043250sodium-dependent organic anion transmembrane transporter activity IEA--
         
    SLC10A6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC10A6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC10A6
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    miRNA
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    Block miRNA regulation of human, mouse, rat SLC10A6 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SLC10A6:
    hsa-miR-193a-3p hsa-miR-193b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SOAT_HUMAN, Q3KNW5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    SLC10A6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC10A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC10A6
        Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Recycling of bile acids and salts



    SLC10A6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC10A6
    Interactions:

        Search GeneGlobe Interaction Network for SLC10A6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC10A6 (ENSP000002739054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NIP7ENSP000002549404STRING: ENSP00000254940
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport ----
    GO:0015711organic anion transport ----
    GO:0043251sodium-dependent organic anion transport IEA--
    GO:0055085transmembrane transport TAS--

    SLC10A6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC10A6 (SOAT)

    1 HMDB Compound for SLC10A6    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC10A6 gene: 
    NM_197965.2  

    Unigene Cluster for SLC10A6:

    Solute carrier family 10 (sodium/bile acid cotransporter family), member 6
    Hs.452996
    Unigene Representative Sequence: NM_197965
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273905(uc003hqd.2) ENST00000505535
    miRNA
    Products:
         
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    2 qRT-PCR Assays for microRNAs that regulate SLC10A6:
    hsa-miR-193a-3p hsa-miR-193b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SLC10A6 (NM_197965)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC10A6
      QuantiTect SYBR Green Assays in human, mouse, rat SLC10A6
      QuantiFast Probe-based Assays in human, mouse, rat SLC10A6

    Additional mRNA sequence: 

    AJ583502.1 BC107051.1 BC107052.1 EF437223.1 

    1 DOTS entry:

    DT.91814753 

    3 AceView cDNA sequences:

    NM_197965 AJ583502 BE181226 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC10A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGATTGTGA
    SLC10A6 Expression
    About this image

    SLC10A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.452996

    UniProtKB/Swiss-Prot: SOAT_HUMAN, Q3KNW5
    Tissue specificity: Highly expressed in testis, placenta and pancreas. Moderately expressed in heart, lung and
    mammary gland. Weakly expressed in brain, colon, kidney, liver, ovary, prostate, small intestine, spleen and
    thymus

        Custom PCR Arrays for SLC10A6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC10A6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc10a61 , 5 solute carrier family 10 (sodium/bile acid cotransporter more1, 5 78.46(n)1
    71.05(a)1
      5 (50.45 cM)5
    757501  NM_029415.21  NP_083691.11 
     1036057115 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc10a61 solute carrier family 10 (sodium/bile acid cotransporter more 60.14(n)
    55.66(a)
      100488946  XM_002936465.1  XP_002936511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116556
    CG99036
    --
    15(a)
    15(a)
    many ↔ many
    many ↔ many
    X(15347504-15349584)
    X(16433186-16434885)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G10AR.46
    Protein Y71G10AR.4 (Y71G10AR.4) mRNA, complete cds...
    16(a)
    1 → many
    IV(2198997-2208831) WBGene00044650


    ENSEMBL Gene Tree for SLC10A6 (if available)
    TreeFam Gene Tree for SLC10A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC10A6 gene
    SLC10A32  SLC10A12  SLC10A42  SLC10A22  SLC10A52  
    3 SIMAP similar genes for SLC10A6 using alignment to 1 protein entry:     SOAT_HUMAN:
    SLC10A2    SLC10A1    SLC10A4

    SLC10A6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC10A6 (see all 576)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339970871,2
    C--83498687(+) GTCTC-/A/AA  
            
    AAAAA
    1 -- int11CSA 2
    rs1428192051,2
    C--87744142(+) GTCAAC/GAAGTC 1 -- ds50010--------
    rs1866958841,2
    --87744331(+) CCAACA/GTGGTG 1 -- ds50010--------
    rs1999423331,2
    C--87744356(+) CTAAA-/ATACAAA 1 -- ds50010--------
    rs1114084571,2
    C,F--87744368(+) ATATTC/AGCCAG 1 -- ds50012Minor allele frequency- A:0.33WA CSA 3
    rs1911469971,2
    --87744378(+) GGCATG/TGTGGC 1 -- ds50010--------
    rs1388731661,2
    --87744447(+) GAGGCA/GGAGGT 1 -- ds50010--------
    rs1494365251,2
    C--87744464(+) GAGCCA/GAGATT 1 -- ds50010--------
    rs1391589661,2
    C,F--87744883(+) GCCCTG/CTGGCA 2 /H /Q mis12Minor allele frequency- C:0.00NA EU 5875
    rs2009830641,2
    --87744969(+) AGAAGC/TCGATT 2 T A mis10--------

    HapMap Linkage Disequilibrium report for SLC10A6 (87744621 - 87770416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC10A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727934CNV Deletion23290073
    nsv830001CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC10A6
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC10A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613366    OMIM disorders: --

    2 diseases for SLC10A6:    
    About MalaCards
    insulin resistance    prostatitis


    SLC10A6 for disorders           About GeneDecksing


    Export disorders for SLC10A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC10A6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC10A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (PubMed id 17491011)1, 2, 3, 9 Geyer J.... Petzinger E. (J. Biol. Chem. 2007)
    2. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PubMed id 16541252)1, 9 Geyer J....Petzinger E. (Naunyn Schmiedebergs Arch. Pharmacol. 2006)
    3. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. (PubMed id 22791750)1 Chen G....Rotimi C. (Hum. Mol. Genet. 2012)
    4. Identification of a sodium-dependent organic anion transporter from rat adrenal gland. (PubMed id 15020217)3 Geyer J....Petzinger E. (Biochem. Biophys. Res. Commun. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345274 HGNC: 30603 AceView: SOAT Ensembl:ENSG00000145283 euGenes: HUgn345274
    ECgene: SLC10A6 H-InvDB: SLC10A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC10A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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