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Aliases for SLC10A5 Gene

Aliases for SLC10A5 Gene

  • Solute Carrier Family 10, Member 5 2 3
  • Solute Carrier Family 10 Member 5 3 4
  • Na(+)/Bile Acid Cotransporter 5 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 5 3
  • Sodium/Bile Acid Cotransporter 5 3
  • P5 3

External Ids for SLC10A5 Gene

Previous GeneCards Identifiers for SLC10A5 Gene

  • GC08U900247
  • GC08M082655
  • GC08M082768
  • GC08M082605
  • GC08M078095

Summaries for SLC10A5 Gene

GeneCards Summary for SLC10A5 Gene

SLC10A5 (Solute Carrier Family 10, Member 5) is a Protein Coding gene. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A5 Gene

Genomics for SLC10A5 Gene

Regulatory Elements for SLC10A5 Gene

Genomic Location for SLC10A5 Gene

Start:
81,693,607 bp from pter
End:
81,696,174 bp from pter
Size:
2,568 bases
Orientation:
Minus strand

Genomic View for SLC10A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC10A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A5 Gene

Proteins for SLC10A5 Gene

  • Protein details for SLC10A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PT55-NTCP5_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter 5
    Protein Accession:
    Q5PT55
    Secondary Accessions:
    • B2RN26

    Protein attributes for SLC10A5 Gene

    Size:
    438 amino acids
    Molecular mass:
    48871 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A5 Gene

Proteomics data for SLC10A5 Gene at MOPED

Post-translational modifications for SLC10A5 Gene

  • Glycosylation at Asn56, Asn85, and Asn99
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A5 Gene

Domains for SLC10A5 Gene

Gene Families for SLC10A5 Gene

Protein Domains for SLC10A5 Gene

Suggested Antigen Peptide Sequences for SLC10A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5PT55

UniProtKB/Swiss-Prot:

NTCP5_HUMAN :
  • Q5PT55
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A5: view

Function for SLC10A5 Gene

Gene Ontology (GO) - Molecular Function for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity IBA --
genes like me logo Genes that share ontologies with SLC10A5: view

Phenotypes for SLC10A5 Gene

GenomeRNAi human phenotypes for SLC10A5:
genes like me logo Genes that share phenotypes with SLC10A5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC10A5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC10A5 Gene

Localization for SLC10A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A5 Gene COMPARTMENTS Subcellular localization image for SLC10A5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC10A5: view

Pathways for SLC10A5 Gene

SuperPathways for SLC10A5 Gene

No Data Available

Interacting Proteins for SLC10A5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000428612%0d%0a9606.ENSP00000254940%0d%0a
Selected Interacting proteins: ENSP00000428612 for SLC10A5 Gene via STRING

Symbol External ID(s) Details
NIP7

Gene Ontology (GO) - Biological Process for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A5: view

No data available for Pathways by source for SLC10A5 Gene

Compounds for SLC10A5 Gene

(1) HMDB Compounds for SLC10A5 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5
genes like me logo Genes that share compounds with SLC10A5: view

Transcripts for SLC10A5 Gene

mRNA/cDNA for SLC10A5 Gene

(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A5 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC10A5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC10A5
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A5 Gene

No ASD Table

Relevant External Links for SLC10A5 Gene

GeneLoc Exon Structure for
SLC10A5
ECgene alternative splicing isoforms for
SLC10A5

Expression for SLC10A5 Gene

mRNA expression in normal human tissues for SLC10A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC10A5 Gene

SOURCE GeneReport for Unigene cluster for SLC10A5 Gene Hs.683849

genes like me logo Genes that share expressions with SLC10A5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC10A5 Gene

Orthologs for SLC10A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A5 35
  • 99.7 (n)
  • 99.32 (a)
SLC10A5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC10A5 35
  • 82.41 (n)
  • 77.65 (a)
SLC10A5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a5 35
  • 77.72 (n)
  • 73.71 (a)
Slc10a5 16
Slc10a5 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC10A5 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc10a5 35
  • 76.77 (n)
  • 72.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 36
  • 19 (a)
ManyToMany
CG9903 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for SLC10A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC10A5 Gene

ENSEMBL:
Gene Tree for SLC10A5 (if available)
TreeFam:
Gene Tree for SLC10A5 (if available)

Paralogs for SLC10A5 Gene

Paralogs for SLC10A5 Gene

Selected SIMAP similar genes for SLC10A5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC10A5 Gene

genes like me logo Genes that share paralogs with SLC10A5: view

Variants for SLC10A5 Gene

Sequence variations from dbSNP and Humsavar for SLC10A5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2955002 -- 81,696,643(-) TTTCC(C/T)AGATT upstream-variant-2KB
rs2955003 -- 81,696,003(-) ACAAG(A/T)GTGTG upstream-variant-2KB
rs2955004 -- 81,695,517(-) TGCAT(C/G)TGGCT upstream-variant-2KB
rs2955006 -- 81,694,547(-) AGAAA(C/T)ATCCT synonymous-codon, reference
rs4546615 -- 81,693,513(+) TGTGT(A/G)TATAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC10A5 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV Gain 19166990
nsv831368 CNV Gain 17160897
nsv831369 CNV Gain+Loss 17160897

Relevant External Links for SLC10A5 Gene

HapMap Linkage Disequilibrium report
SLC10A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A5 Gene

Disorders for SLC10A5 Gene

No disorders were found for SLC10A5 Gene.

No data available for UniProtKB/Swiss-Prot for SLC10A5 Gene

Publications for SLC10A5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J. … Petzinger E. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 3
  3. The novel putative bile acid transporter SLC10A5 is highly expressed in liver and kidney. (PMID: 17632081) Fernandes C.F. … Geyer J. (Biochem. Biophys. Res. Commun. 2007) 3
  4. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC10A5 Gene

  • antibodies-online peptides for SLC10A5
  • antibodies-online antibodies for SLC10A5
  • antibodies-online kits for SLC10A5

Sources for SLC10A5 Gene

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