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Aliases for SLC10A5 Gene

Aliases for SLC10A5 Gene

  • Solute Carrier Family 10 Member 5 2 3 4 5
  • Solute Carrier Family 10, Member 5 2 3
  • Na(+)/Bile Acid Cotransporter 5 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 5 3
  • P5 3

External Ids for SLC10A5 Gene

Previous GeneCards Identifiers for SLC10A5 Gene

  • GC08U900247
  • GC08M082655
  • GC08M082768
  • GC08M082605
  • GC08M078095

Summaries for SLC10A5 Gene

GeneCards Summary for SLC10A5 Gene

SLC10A5 (Solute Carrier Family 10 Member 5) is a Protein Coding gene. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A5 Gene

Genomics for SLC10A5 Gene

Regulatory Elements for SLC10A5 Gene

Enhancers for SLC10A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC10A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A5 Gene

Chromosome:
8
Start:
81,693,607 bp from pter
End:
81,696,174 bp from pter
Size:
2,568 bases
Orientation:
Minus strand

Genomic View for SLC10A5 Gene

Genes around SLC10A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A5 Gene

Proteins for SLC10A5 Gene

  • Protein details for SLC10A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PT55-NTCP5_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter 5
    Protein Accession:
    Q5PT55
    Secondary Accessions:
    • B2RN26

    Protein attributes for SLC10A5 Gene

    Size:
    438 amino acids
    Molecular mass:
    48871 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A5 Gene

Proteomics data for SLC10A5 Gene at MOPED

Post-translational modifications for SLC10A5 Gene

  • Glycosylation at Asn 56, Asn 85, and Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A5 Gene

Domains & Families for SLC10A5 Gene

Gene Families for SLC10A5 Gene

Protein Domains for SLC10A5 Gene

Suggested Antigen Peptide Sequences for SLC10A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5PT55

UniProtKB/Swiss-Prot:

NTCP5_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A5: view

Function for SLC10A5 Gene

genes like me logo Genes that share phenotypes with SLC10A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A5

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A5 Gene

Localization for SLC10A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A5 Gene COMPARTMENTS Subcellular localization image for SLC10A5 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC10A5: view

Pathways & Interactions for SLC10A5 Gene

SuperPathways for SLC10A5 Gene

No Data Available

Interacting Proteins for SLC10A5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000428612%0d%0a9606.ENSP00000254940%0d%0a
Selected Interacting proteins: ENSP00000428612 for SLC10A5 Gene via STRING

Symbol External ID(s) Details
NIP7

Gene Ontology (GO) - Biological Process for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with SLC10A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A5 Gene

Drugs & Compounds for SLC10A5 Gene

(1) Additional Compounds for SLC10A5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A5: view

Transcripts for SLC10A5 Gene

mRNA/cDNA for SLC10A5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A5 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A5 Gene

No ASD Table

Relevant External Links for SLC10A5 Gene

GeneLoc Exon Structure for
SLC10A5
ECgene alternative splicing isoforms for
SLC10A5

Expression for SLC10A5 Gene

mRNA expression in normal human tissues for SLC10A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for SLC10A5 Gene

This gene is overexpressed in Serum (36.2), Blymphocyte (26.8), and Neutrophil (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC10A5 Gene



SOURCE GeneReport for Unigene cluster for SLC10A5 Gene Hs.683849

genes like me logo Genes that share expression patterns with SLC10A5: view

Protein tissue co-expression partners for SLC10A5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC10A5 Gene

Orthologs for SLC10A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC10A5 35
  • 82.41 (n)
  • 77.65 (a)
SLC10A5 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a5 35
  • 77.72 (n)
  • 73.71 (a)
Slc10a5 16
Slc10a5 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC10A5 35
  • 99.7 (n)
  • 99.32 (a)
SLC10A5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc10a5 35
  • 76.77 (n)
  • 72.73 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC10A5 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11655 36
  • 19 (a)
ManyToMany
CG9903 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for SLC10A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC10A5 Gene

ENSEMBL:
Gene Tree for SLC10A5 (if available)
TreeFam:
Gene Tree for SLC10A5 (if available)

Paralogs for SLC10A5 Gene

Paralogs for SLC10A5 Gene

(2) SIMAP similar genes for SLC10A5 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SLC10A5 Gene

genes like me logo Genes that share paralogs with SLC10A5: view

Variants for SLC10A5 Gene

Sequence variations from dbSNP and Humsavar for SLC10A5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7012758 - 81,694,113(+) TTCCA(A/G)TTGAT reference, missense
rs2955002 -- 81,696,643(-) TTTCC(C/T)AGATT upstream-variant-2KB
rs2955003 -- 81,696,003(-) ACAAG(A/T)GTGTG upstream-variant-2KB
rs2955004 -- 81,695,517(-) TGCAT(C/G)TGGCT upstream-variant-2KB
rs2955006 -- 81,694,547(-) AGAAA(C/T)ATCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC10A5 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV Gain 19166990
nsv831368 CNV Gain 17160897
nsv831369 CNV Gain+Loss 17160897

Variation tolerance for SLC10A5 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A5 Gene

HapMap Linkage Disequilibrium report
SLC10A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A5 Gene

Disorders for SLC10A5 Gene

Relevant External Links for SLC10A5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A5

No disorders were found for SLC10A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A5 Gene

Publications for SLC10A5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3
  3. The novel putative bile acid transporter SLC10A5 is highly expressed in liver and kidney. (PMID: 17632081) Fernandes C.F. … Geyer J. (Biochem. Biophys. Res. Commun. 2007) 3
  4. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J. … Petzinger E. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC10A5 Gene

Sources for SLC10A5 Gene

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