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Aliases for SLC10A5 Gene

Aliases for SLC10A5 Gene

  • Solute Carrier Family 10 Member 5 2 3 4 5
  • Na(+)/Bile Acid Cotransporter 5 2 3 4
  • Sodium/Bile Acid Cotransporter 5 2 3
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 5 3
  • Solute Carrier Family 10, Member 5 2
  • P5 3

External Ids for SLC10A5 Gene

Previous GeneCards Identifiers for SLC10A5 Gene

  • GC08U900247
  • GC08M082655
  • GC08M082768
  • GC08M082605
  • GC08M078095

Summaries for SLC10A5 Gene

GeneCards Summary for SLC10A5 Gene

SLC10A5 (Solute Carrier Family 10 Member 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A3.

Additional gene information for SLC10A5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A5 Gene

Genomics for SLC10A5 Gene

GeneHancer (GH) Regulatory Elements for SLC10A5 Gene

Promoters and enhancers for SLC10A5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I081692 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +1.8 1769 3.1 ELF3 SOX13 FOXA2 ZNF792 SAP130 ARID4B ZNF644 YY1 GATA3 POLR2A ENSG00000280193 SLC10A5 IMPA1 CHMP4C ZFAND1
GH08I081696 Promoter 0.8 EPDnew 550.8 -0.1 -101 0.1 SSRP1 POLR2A ATF3 ZNF507 ENSG00000280193 SLC10A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC10A5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC10A5 gene promoter:

Genomic Locations for SLC10A5 Gene

Genomic Locations for SLC10A5 Gene
2,568 bases
Minus strand

Genomic View for SLC10A5 Gene

Genes around SLC10A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A5 Gene

Proteins for SLC10A5 Gene

  • Protein details for SLC10A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/bile acid cotransporter 5
    Protein Accession:
    Secondary Accessions:
    • B2RN26

    Protein attributes for SLC10A5 Gene

    438 amino acids
    Molecular mass:
    48871 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A5 Gene

Post-translational modifications for SLC10A5 Gene

  • Glycosylation at posLast=5656, isoforms=85, and isoforms=99

Other Protein References for SLC10A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A5 Gene

Domains & Families for SLC10A5 Gene

Gene Families for SLC10A5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC10A5 Gene

Suggested Antigen Peptide Sequences for SLC10A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A5: view

Function for SLC10A5 Gene

Gene Ontology (GO) - Molecular Function for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A5: view
genes like me logo Genes that share phenotypes with SLC10A5: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A5 Gene

Localization for SLC10A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A5 gene
Compartment Confidence
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC10A5: view

Pathways & Interactions for SLC10A5 Gene

SuperPathways for SLC10A5 Gene

No Data Available

Interacting Proteins for SLC10A5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000428612 for SLC10A5 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A5 Gene

Drugs & Compounds for SLC10A5 Gene

(1) Additional Compounds for SLC10A5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC10A5: view

Transcripts for SLC10A5 Gene

mRNA/cDNA for SLC10A5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A5 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A5 Gene

No ASD Table

Relevant External Links for SLC10A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC10A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A5 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.4).

Protein differential expression in normal tissues from HIPED for SLC10A5 Gene

This gene is overexpressed in Serum (36.2), Blymphocyte (26.8), and Neutrophil (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC10A5 Gene

Protein tissue co-expression partners for SLC10A5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC10A5 Gene:


SOURCE GeneReport for Unigene cluster for SLC10A5 Gene:


Evidence on tissue expression from TISSUES for SLC10A5 Gene

  • Liver(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SLC10A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A5 Gene

Orthologs for SLC10A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC10A5 33 34
  • 99.7 (n)
(Bos Taurus)
Mammalia SLC10A5 33 34
  • 82.41 (n)
(Mus musculus)
Mammalia Slc10a5 33 16 34
  • 77.72 (n)
(Rattus norvegicus)
Mammalia Slc10a5 33
  • 76.77 (n)
(Monodelphis domestica)
Mammalia SLC10A5 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 34
  • 19 (a)
CG9903 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
-- 34
  • 34 (a)
Species where no ortholog for SLC10A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC10A5 Gene

Gene Tree for SLC10A5 (if available)
Gene Tree for SLC10A5 (if available)

Paralogs for SLC10A5 Gene

Paralogs for SLC10A5 Gene

(2) SIMAP similar genes for SLC10A5 Gene using alignment to 1 proteins: Pseudogenes for SLC10A5 Gene

genes like me logo Genes that share paralogs with SLC10A5: view

Variants for SLC10A5 Gene

Sequence variations from dbSNP and Humsavar for SLC10A5 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000537153 -- 81,693,480(-) C/T downstream_transcript_variant
rs1002013756 -- 81,696,084(-) G/A upstream_transcript_variant
rs1002554387 -- 81,695,822(-) C/T upstream_transcript_variant
rs1003535014 -- 81,696,173(-) G/A upstream_transcript_variant
rs1005129124 -- 81,694,855(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A5 Gene

Variant ID Type Subtype PubMed ID
nsv465721 CNV gain 19166990
nsv611607 CNV gain 21841781
nsv831368 CNV gain 17160897
nsv831369 CNV gain+loss 17160897

Variation tolerance for SLC10A5 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC10A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A5 Gene

Disorders for SLC10A5 Gene

Additional Disease Information for SLC10A5

No disorders were found for SLC10A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A5 Gene

Publications for SLC10A5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah PD … Sellers TA (Nature genetics 2013) 3 58
  3. The novel putative bile acid transporter SLC10A5 is highly expressed in liver and kidney. (PMID: 17632081) Fernandes CF … Geyer J (Biochemical and biophysical research communications 2007) 3 58
  4. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J … Petzinger E (Naunyn-Schmiedeberg's archives of pharmacology 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SLC10A5 Gene

Sources for SLC10A5 Gene

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