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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC10A5 Gene

protein-coding   GIFtS: 41
GCID: GC08M082605

Solute Carrier Family 10, Member 5

  Search for SLC10A5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 10, Member 51 2
Solute Carrier Family 10 Member 52 3
Na(+)/Bile Acid Cotransporter 52 3
P52
Sodium/Bile Acid Cotransporter 52
Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 52

External Ids:    HGNC: 229811   Entrez Gene: 3470512   Ensembl: ENSG000002535987   UniProtKB: Q5PT553   
ORGUL members:         
NONCODE14:n341549      

Export aliases for SLC10A5 gene to outside databases

Previous GC identifers: GC08U900247 GC08M082655 GC08M082768 GC08M078095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC10A5 Gene: 
SLC10A5 (solute carrier family 10, member 5) is a protein-coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC10A5 gene promoter:
         RORalpha1   c-Rel   NRF-2   Lmo2   E47   Evi-1   Hlf   Egr-4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLC10A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

SLC10A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC10A5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M082605:  view genomic region     (about GC identifiers)

Start:
82,605,842 bp from pter      End:
82,608,409 bp from pter
Size:
2,568 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTCP5_HUMAN, Q5PT55 (See protein sequence)
Recommended Name: Sodium/bile acid cotransporter 5 precursor  
Size: 438 amino acids; 48871 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RN26

Explore the universe of human proteins at neXtProt for SLC10A5: NX_Q5PT55

Explore proteomics data for SLC10A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5PT55

  • SLC10A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC10A5 Protein Expression
    REFSEQ proteins: NP_001010893.1  
    ENSEMBL proteins: 
     ENSP00000428612  

    Human Recombinant Protein Products for SLC10A5: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC10A5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/bile acid cotransporter 5 
    SLC10 family of sodium-bile acid co-transporters

    1 InterPro protein domain:
     IPR002657 BilAc/Na_symport

    Graphical View of Domain Structure for InterPro Entry Q5PT55

    ProtoNet protein and cluster: Q5PT55

    1 Blocks protein domain: IPB002657 Bile acid:sodium symporter

    UniProtKB/Swiss-Prot: NTCP5_HUMAN, Q5PT55
    Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family


    SLC10A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008508bile acid:sodium symporter activity IEA--
         
    SLC10A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC10A5:
     Decreased viability with pacli 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC10A5

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport ----

    SLC10A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC10A5 (NTCP5)

    1 HMDB Compound for SLC10A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC10A5 / NTCP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC10A5 gene: 
    NM_001010893.2  

    Unigene Cluster for SLC10A5:

    Solute carrier family 10 (sodium/bile acid cotransporter family), member 5
    Hs.683849
    Unigene Representative Sequence: AK095808
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000518568(uc011lfs.2)
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK095808.1 AY825924.1 BC136625.1 BC136631.1 

    1 DOTS entry:

    DT.99935560 

    1 AceView cDNA sequence:

    AK095808 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC10A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCTGGAT
    SLC10A5 Expression
    About this image


    See SLC10A5 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.683849
        SABiosciences Custom PCR Arrays for SLC10A5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC10A5 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc10a51 , 5 solute carrier family 10 (sodium/bile acid cotransporter more1, 5 77.4(n)1
    73.56(a)1
      3 (2.62 cM)5
    2418771  NM_001010834.21  NP_001010834.11 
     103317345 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116556
    CG99036
    --
    16(a)
    16(a)
    many ↔ many
    many ↔ many
    X(15347504-15349584)
    X(16433186-16434885)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G10AR.46
    Protein Y71G10AR.4
    15(a)
    1 → many
    IV(2198997-2204545)


    ENSEMBL Gene Tree for SLC10A5 (if available)
    TreeFam Gene Tree for SLC10A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC10A5 gene
    SLC10A32  SLC10A12  SLC10A62  SLC10A42  SLC10A22  
    2 SIMAP similar genes for SLC10A5 using alignment to 1 protein entry:     NTCP5_HUMAN:
    SLC10A3    SLC10A2

    SLC10A5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC10A5
    PGOHUM00000249408


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 SNPs in SLC10A5 are shown (see all 124)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs736947061,2
    C,F--82605437(+) AACATA/GCTTAT 1 -- ds50015Minor allele frequency- G:0.10WA CSA NA EA 362
    rs736947071,2
    C,F--82605452(+) ATGTGC/TTAATG 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs1928865411,2
    --82605555(+) TAAATA/GAGTTT 1 -- ds50010--------
    rs106533091,2
    C--82605718(+) ACGAA-/TG    
       
    /TGTG
    tgtgt
    1 -- ds50010--------
    rs45466151,2
    C,F,A--82605748(+) TGTGTA/GTATAT 1 -- ds50014Minor allele frequency- G:0.45NA CSA 125
    rs783731101,2
    C--82605750(+) TGTATA/GTATAT 1 -- ds50010--------
    rs1423416441,2
    F--82605998(+) CATGGC/ATACTG 2 /A /S mis11Minor allele frequency- A:0.00NA 4526
    rs1430462601,2
    C--82606131(+) GGCAGA/CGTACA 2 T syn10--------
    rs1996927611,2
    C--82606149(+) GCAAAG/AGAGTA 2 /S syn11Minor allele frequency- A:0.00EU 1315
    rs1424220171,2
    C,F--82606244(+) TGTGAA/GAGTCA 2 L F mis12Minor allele frequency- G:0.00NA EU 5045

    HapMap Linkage Disequilibrium report for SLC10A5 (82605842 - 82608409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC10A5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831368CNV Gain17160897
    nsv465721CNV Gain19166990
    nsv831369CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC10A5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC10A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. GWAS meta-analysis and replication identifies three ne w susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (2013)
    3. The novel putative bile acid transporter SLC10A5 is highly expressed in liver and kidney. (PubMed id 17632081)1 Fernandes C.F....Geyer J. (2007)
    4. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PubMed id 16541252)1 Geyer J....Petzinger E. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 347051 HGNC: 22981 AceView: SLC10A5 Ensembl:ENSG00000253598 euGenes: HUgn347051
    ECgene: SLC10A5 H-InvDB: SLC10A5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC10A5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC10A5 gene:
    Search GeneIP for patents involving SLC10A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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