SLC10A5 Gene
protein-coding GIFtS: 38
GCID: GC08M082605
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solute carrier family 10 (sodium/bile acid cotransporter...
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Aliases
for SLC10A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member51 2 | | Solute Carrier Family 10 Member 52 3 | | Na(+)/Bile Acid Cotransporter 52 3 | | P52 | | Sodium/Bile Acid Cotransporter 52 |
| External Ids: | HGNC: 229811 | Entrez Gene: 3470512 | Ensembl: ENSG000002535987 | UniProtKB: Q5PT553 | | ORGUL members: | |
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| NONCODE:n341549 | |
Export aliases for SLC10A5 gene to outside databasesPrevious GC identifers: GC08U900247 GC08M082655 GC08M082768 GC08M078095
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Summaries
for SLC10A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC10A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC10A5 gene promoter:
RORalpha1 c-Rel NRF-2 Lmo2 E47 Evi-1 Hlf Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC10A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.13 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.13SLC10A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M082605: view genomic region
(about GC identifiers)
Start:
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82,605,842 bp from pter |
End:
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82,608,409 bp from pter |
Size:
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2,568 bases |
Orientation:
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minus strand |
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Proteins
for SLC10A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NTCP5_HUMAN, Q5PT55 (See
protein sequence)Recommended Name: Sodium/bile acid cotransporter 5 precursor Size: 438 amino acids; 48871 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RN26Explore the universe of human proteins at neXtProt for SLC10A5: NX_Q5PT55
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5PT55
SLC10A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010893.1
ENSEMBL proteins: ENSP00000428612
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC10A5 for ontologies About GeneDecksing
SLC10A5 Antibody Products:
Assay Products for SLC10A5: |
Protein
Domains /
Families
for SLC10A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC10A5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5PT55ProtoNet protein and cluster: Q5PT55 1 Blocks protein family: IPB002657 Bile acid:sodium symporter
UniProtKB/Swiss-Prot: NTCP5_HUMAN, Q5PT55Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family |
Function
for SLC10A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC10A5 (NM_001010893) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC10A5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008508 | bile acid:sodium symporter activity |
IEA | -- |
SLC10A5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLC10A5:
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Pathways & Interactions
for SLC10A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC10A5
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Drugs & Compounds
for SLC10A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC10A5
1 HMDB Compound for SLC10A5 About this table
Search CenterWatch for drugs/clinical trials and news about SLC10A5 / NTCP5
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Transcripts
for SLC10A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC10A5 gene: NM_001010893.2 Unigene Cluster for SLC10A5: Solute carrier family 10 (sodium/bile acid cotransporter family), member 5 Hs.683849 Unigene Representative Sequence: AK0958081 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000518568(uc011lfs.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC10A5 (NM_001010893) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC10A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A5 |
Additional cDNA sequence: AK095808.1 AY825924.1 BC136625.1 BC136631.1 1 DOTS entry: DT.99935560 1 AceView cDNA sequence: AK095808
GeneLoc Exon Structure
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Expression
for SLC10A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC10A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTCTGGAT
About this image
See SLC10A5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.683849
SABiosciences Custom PCR Arrays for SLC10A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC10A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A5 |
Orthologs
for SLC10A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC10A5 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for SLC10A5 (if available)
TreeFam Gene Tree for SLC10A5 (if available) |
Paralogs
for SLC10A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC10A5 gene
- SLC10A32 SLC10A62 SLC10A12 SLC10A42 SLC10A22
2 SIMAP similar genes for SLC10A5 using alignment to 1 protein entry: NTCP5_HUMAN:SLC10A3 SLC10A2
SLC10A5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLC10A5
PGOHUM00000249408
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Genomic Variants
for SLC10A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC10A5 (82605842 - 82608409 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC10A5: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SLC10A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for SLC10A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC10A5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC10A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The novel putative bile acid transporter SLC10A5 is highly expressed in liver and kidney. (PubMed id 17632081)1 Fernandes C.F....Geyer J. (2007)
- The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PubMed id 16541252)1 Geyer J....Petzinger E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SLC10A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SLC10A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SLC10A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC10A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC10A5 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SLC10A5 gene:
Search GeneIP for patents involving SLC10A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC10A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC10A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC10A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC10A5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC10A5 | | OriGene Custom Protein Services for SLC10A5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC10A5 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC10A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A5 |
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 |  |  |  | |
| | | | Search Tocris compounds for SLC10A5 |
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 | | | SLC10A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A5 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC10A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A5 |
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