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Aliases for SLC10A4 Gene

Aliases for SLC10A4 Gene

  • Solute Carrier Family 10 Member 4 2 3 4 5
  • Solute Carrier Family 10, Member 4 2 3
  • Na(+)/Bile Acid Cotransporter 4 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 4 3
  • Bile Acid Transporter SLC10A4 3
  • P4 3

External Ids for SLC10A4 Gene

Previous GeneCards Identifiers for SLC10A4 Gene

  • GC04P048335
  • GC04P048400
  • GC04P048326
  • GC04P048180
  • GC04P047805

Summaries for SLC10A4 Gene

GeneCards Summary for SLC10A4 Gene

SLC10A4 (Solute Carrier Family 10 Member 4) is a Protein Coding gene. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A6.

UniProtKB/Swiss-Prot for SLC10A4 Gene

  • Transporter for bile acids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A4 Gene

Genomics for SLC10A4 Gene

Regulatory Elements for SLC10A4 Gene

Promoters for SLC10A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC10A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A4 Gene

Chromosome:
4
Start:
48,483,343 bp from pter
End:
48,489,524 bp from pter
Size:
6,182 bases
Orientation:
Plus strand

Genomic View for SLC10A4 Gene

Genes around SLC10A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A4 Gene

Proteins for SLC10A4 Gene

  • Protein details for SLC10A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EP9-NTCP4_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter 4
    Protein Accession:
    Q96EP9
    Secondary Accessions:
    • Q8WUZ2

    Protein attributes for SLC10A4 Gene

    Size:
    437 amino acids
    Molecular mass:
    46504 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A4 Gene

Proteomics data for SLC10A4 Gene at MOPED

Post-translational modifications for SLC10A4 Gene

  • Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.
  • Ubiquitination at Lys 407
  • Glycosylation at Asn 6, Asn 18, Asn 24, Asn 181, and Asn 195
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC10A4 Gene

Domains & Families for SLC10A4 Gene

Gene Families for SLC10A4 Gene

Protein Domains for SLC10A4 Gene

Suggested Antigen Peptide Sequences for SLC10A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EP9

UniProtKB/Swiss-Prot:

NTCP4_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A4: view

Function for SLC10A4 Gene

Molecular function for SLC10A4 Gene

UniProtKB/Swiss-Prot Function:
Transporter for bile acids.
genes like me logo Genes that share phenotypes with SLC10A4: view

Animal Models for SLC10A4 Gene

MGI Knock Outs for SLC10A4:

Animal Model Products

CRISPR Products

miRNA for SLC10A4 Gene

miRTarBase miRNAs that target SLC10A4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC10A4 Gene

Localization for SLC10A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A4 Gene COMPARTMENTS Subcellular localization image for SLC10A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC10A4: view

Pathways & Interactions for SLC10A4 Gene

SuperPathways for SLC10A4 Gene

No Data Available

Interacting Proteins for SLC10A4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273861%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000254940%0d%0a
Selected Interacting proteins: ENSP00000273861 for SLC10A4 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with SLC10A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A4 Gene

Drugs & Compounds for SLC10A4 Gene

(1) Additional Compounds for SLC10A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A4: view

Transcripts for SLC10A4 Gene

mRNA/cDNA for SLC10A4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A4 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A4 Gene

No ASD Table

Relevant External Links for SLC10A4 Gene

GeneLoc Exon Structure for
SLC10A4
ECgene alternative splicing isoforms for
SLC10A4

Expression for SLC10A4 Gene

mRNA expression in normal human tissues for SLC10A4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A4 Gene

This gene is overexpressed in Brain - Substantia nigra (x12.3), Pituitary (x5.5), and Brain - Hypothalamus (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC10A4 Gene



SOURCE GeneReport for Unigene cluster for SLC10A4 Gene Hs.132591

mRNA Expression by UniProt/SwissProt for SLC10A4 Gene

Q96EP9-NTCP4_HUMAN
Tissue specificity: Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.
genes like me logo Genes that share expression patterns with SLC10A4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for SLC10A4 Gene

Orthologs for SLC10A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC10A4 35
  • 88.12 (n)
  • 86.44 (a)
SLC10A4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC10A4 35
  • 88.37 (n)
  • 90.34 (a)
SLC10A4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a4 35
  • 83.75 (n)
  • 87.36 (a)
Slc10a4 16
Gm5868 36
  • 92 (a)
OneToMany
Slc10a4 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc10a4 35
  • 84.6 (n)
  • 87.13 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC10A4 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A4 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC10A4 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC10A4 35
  • 70.02 (n)
  • 71.79 (a)
SLC10A4 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC10A4 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a4 35
  • 69.28 (n)
  • 73.19 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15580 35
slc10a4 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11655 36
  • 15 (a)
ManyToMany
CG9903 36
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
Species with no ortholog for SLC10A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A4 Gene

ENSEMBL:
Gene Tree for SLC10A4 (if available)
TreeFam:
Gene Tree for SLC10A4 (if available)

Paralogs for SLC10A4 Gene

Paralogs for SLC10A4 Gene

(3) SIMAP similar genes for SLC10A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC10A4: view

Variants for SLC10A4 Gene

Sequence variations from dbSNP and Humsavar for SLC10A4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6447640 -- 48,481,399(+) ACCAT(A/G)CCCAA upstream-variant-2KB
rs6812622 -- 48,487,822(+) tttgg(G/T)gaaat intron-variant
rs6812980 -- 48,482,043(+) TATCC(G/T)CCTAG upstream-variant-2KB
rs6836632 -- 48,483,058(+) TTTCT(A/G)CCATG upstream-variant-2KB
rs6829144 -- 48,487,752(+) TTCAG(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A4 Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV Gain 18288195
nsv829925 CNV Gain+Loss 17160897
dgv5542n71 CNV Loss 21882294

Variation tolerance for SLC10A4 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A4 Gene

HapMap Linkage Disequilibrium report
SLC10A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A4 Gene

Disorders for SLC10A4 Gene

Relevant External Links for SLC10A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A4

No disorders were found for SLC10A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A4 Gene

Publications for SLC10A4 Gene

  1. SLC10A4 is a protease-activated transporter that transports bile acids. (PMID: 23589386) Abe T. … Tomioka Y. (J. Biochem. 2013) 3 4 67
  2. Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration. (PMID: 23948907) Popova S.N. … Alafuzoff I. (J. Alzheimers Dis. 2013) 3
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  4. Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. (PMID: 18355966) Geyer J. … Petzinger E. (Neuroscience 2008) 23
  5. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PMID: 16541252) Geyer J. … Petzinger E. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 3

Products for SLC10A4 Gene

Sources for SLC10A4 Gene

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