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Aliases for SLC10A4 Gene

Aliases for SLC10A4 Gene

  • Solute Carrier Family 10 Member 4 2 3 4 5
  • Na(+)/Bile Acid Cotransporter 4 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 4 3
  • Solute Carrier Family 10, Member 4 2
  • Sodium/Bile Acid Cotransporter 4 3
  • Bile Acid Transporter SLC10A4 3
  • P4 3

External Ids for SLC10A4 Gene

Previous GeneCards Identifiers for SLC10A4 Gene

  • GC04P048335
  • GC04P048400
  • GC04P048326
  • GC04P048180
  • GC04P047805

Summaries for SLC10A4 Gene

GeneCards Summary for SLC10A4 Gene

SLC10A4 (Solute Carrier Family 10 Member 4) is a Protein Coding gene. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A1.

UniProtKB/Swiss-Prot for SLC10A4 Gene

  • Transporter for bile acids.

Additional gene information for SLC10A4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A4 Gene

Genomics for SLC10A4 Gene

Regulatory Elements for SLC10A4 Gene

Enhancers for SLC10A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H048775 1.6 Ensembl ENCODE dbSUPER 6.3 +295.1 295091 6 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 ZNF207 FOS OCIAD1 SLAIN2 NFXL1 TEC SLC10A4 FRYL GC04P048658
GH04H048375 1.1 Ensembl ENCODE 9 -107.3 -107341 1 FOXA2 FEZF1 ZNF2 CHAMP1 YY1 ZSCAN5C FOS KLF7 ZNF362 OVOL3 SLC10A4 GC04M048339
GH04H048697 1.5 Ensembl ENCODE dbSUPER 6.3 +216.3 216307 4 PKNOX1 FOXA2 ATF1 ARNT YY1 TCF12 ZNF121 GATA2 FOS ATF7 OCIAD1 SLC10A4 CWH43 GC04P048658 FRYL
GH04H048336 1.4 FANTOM5 ENCODE 5.9 -143.1 -143057 6 HDGF ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 SP3 SP5 TEC ZAR1 TXK SLAIN2 SLC10A4 GC04M048291
GH04H048683 1.2 Ensembl ENCODE 6.3 +201.0 200987 1 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ATF7 NCOA1 REST OCIAD1 SLC10A4 CNGA1 GC04P048658 FRYL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC10A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A4 Gene

Chromosome:
4
Start:
48,483,343 bp from pter
End:
48,489,524 bp from pter
Size:
6,182 bases
Orientation:
Plus strand

Genomic View for SLC10A4 Gene

Genes around SLC10A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A4 Gene

Proteins for SLC10A4 Gene

  • Protein details for SLC10A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EP9-NTCP4_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter 4
    Protein Accession:
    Q96EP9
    Secondary Accessions:
    • Q8WUZ2

    Protein attributes for SLC10A4 Gene

    Size:
    437 amino acids
    Molecular mass:
    46504 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A4 Gene

Post-translational modifications for SLC10A4 Gene

  • Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.
  • Ubiquitination at Lys407
  • Glycosylation at isoforms=6, Asn18, isoforms=24, isoforms=181, and isoforms=195
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A4 Gene

Domains & Families for SLC10A4 Gene

Gene Families for SLC10A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC10A4 Gene

Suggested Antigen Peptide Sequences for SLC10A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EP9

UniProtKB/Swiss-Prot:

NTCP4_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A4: view

Function for SLC10A4 Gene

Molecular function for SLC10A4 Gene

UniProtKB/Swiss-Prot Function:
Transporter for bile acids.

Phenotypes From GWAS Catalog for SLC10A4 Gene

Gene Ontology (GO) - Molecular Function for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A4: view
genes like me logo Genes that share phenotypes with SLC10A4: view

Animal Models for SLC10A4 Gene

MGI Knock Outs for SLC10A4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A4

CRISPR Products

miRNA for SLC10A4 Gene

miRTarBase miRNAs that target SLC10A4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC10A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC10A4 Gene

Localization for SLC10A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC10A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC10A4 Gene

Pathways & Interactions for SLC10A4 Gene

SuperPathways for SLC10A4 Gene

No Data Available

Interacting Proteins for SLC10A4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273861%0d%0a9606.ENSP00000306397%0d%0a9606.ENSP00000254940%0d%0a9606.ENSP00000316596%0d%0a
Selected Interacting proteins: ENSP00000273861 for SLC10A4 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A4 Gene

Drugs & Compounds for SLC10A4 Gene

(1) Additional Compounds for SLC10A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A4: view

Transcripts for SLC10A4 Gene

mRNA/cDNA for SLC10A4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A4 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC10A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A4 Gene

No ASD Table

Relevant External Links for SLC10A4 Gene

GeneLoc Exon Structure for
SLC10A4
ECgene alternative splicing isoforms for
SLC10A4

Expression for SLC10A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A4 Gene

This gene is overexpressed in Brain - Substantia nigra (x12.3), Pituitary (x5.5), and Brain - Hypothalamus (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC10A4 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC10A4 Gene:

SLC10A4

SOURCE GeneReport for Unigene cluster for SLC10A4 Gene:

Hs.132591

mRNA Expression by UniProt/SwissProt for SLC10A4 Gene:

Q96EP9-NTCP4_HUMAN
Tissue specificity: Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.

Evidence on tissue expression from TISSUES for SLC10A4 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SLC10A4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A4 Gene

Orthologs for SLC10A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A4 34
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5868 34
  • 92 (a)
OneToMany
Slc10a4 33 16 34
  • 83.75 (n)
dog
(Canis familiaris)
Mammalia SLC10A4 33 34
  • 88.37 (n)
cow
(Bos Taurus)
Mammalia SLC10A4 33 34
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia Slc10a4 33
  • 84.6 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC10A4 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A4 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC10A4 33 34
  • 70.02 (n)
lizard
(Anolis carolinensis)
Reptilia SLC10A4 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a4 33
  • 69.28 (n)
zebrafish
(Danio rerio)
Actinopterygii slc10a4 34
  • 61 (a)
OneToOne
Dr.15580 33
fruit fly
(Drosophila melanogaster)
Insecta CG11655 34
  • 15 (a)
ManyToMany
CG9903 34
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 34
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
-- 34
  • 28 (a)
OneToMany
Species where no ortholog for SLC10A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A4 Gene

ENSEMBL:
Gene Tree for SLC10A4 (if available)
TreeFam:
Gene Tree for SLC10A4 (if available)

Paralogs for SLC10A4 Gene

Paralogs for SLC10A4 Gene

(3) SIMAP similar genes for SLC10A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC10A4: view

Variants for SLC10A4 Gene

Sequence variations from dbSNP and Humsavar for SLC10A4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1001396672 -- 48,484,177(+) TGGGC(A/G)TCTGT intron-variant
rs1001468558 -- 48,484,441(+) TCGGG(G/T)TGGCA intron-variant
rs1003524575 -- 48,489,985(+) ATGAG(-/T)TTTCT downstream-variant-500B, upstream-variant-2KB
rs1003741661 -- 48,483,045(+) GCTAT(A/G)GGAAC upstream-variant-2KB
rs1005146291 -- 48,485,497(+) AATAA(A/C)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A4 Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV gain 18288195
nsv594121 CNV gain 21841781
nsv829925 CNV gain+loss 17160897

Variation tolerance for SLC10A4 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC10A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A4 Gene

Disorders for SLC10A4 Gene

Relevant External Links for SLC10A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC10A4

No disorders were found for SLC10A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A4 Gene

Publications for SLC10A4 Gene

  1. SLC10A4 is a protease-activated transporter that transports bile acids. (PMID: 23589386) Abe T … Tomioka Y (Journal of biochemistry 2013) 3 4 60
  2. Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. (PMID: 18355966) Geyer J … Petzinger E (Neuroscience 2008) 4 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes. (PMID: 26084360) Schmidt S … Geyer J (BMC neuroscience 2015) 3 60
  5. Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration. (PMID: 23948907) Popova SN … Alafuzoff I (Journal of Alzheimer's disease : JAD 2013) 3 60

Products for SLC10A4 Gene

Sources for SLC10A4 Gene

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