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Aliases for SLC10A4 Gene

Aliases for SLC10A4 Gene

  • Solute Carrier Family 10 Member 4 2 3 4 5
  • Solute Carrier Family 10, Member 4 2 3
  • Na(+)/Bile Acid Cotransporter 4 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 4 3
  • Bile Acid Transporter SLC10A4 3
  • P4 3

External Ids for SLC10A4 Gene

Previous GeneCards Identifiers for SLC10A4 Gene

  • GC04P048335
  • GC04P048400
  • GC04P048326
  • GC04P048180
  • GC04P047805

Summaries for SLC10A4 Gene

GeneCards Summary for SLC10A4 Gene

SLC10A4 (Solute Carrier Family 10 Member 4) is a Protein Coding gene. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A6.

UniProtKB/Swiss-Prot for SLC10A4 Gene

  • Transporter for bile acids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A4 Gene

Genomics for SLC10A4 Gene

Regulatory Elements for SLC10A4 Gene

Enhancers for SLC10A4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC10A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC10A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC10A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A4 Gene

48,483,343 bp from pter
48,489,524 bp from pter
6,182 bases
Plus strand

Genomic View for SLC10A4 Gene

Genes around SLC10A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A4 Gene

Proteins for SLC10A4 Gene

  • Protein details for SLC10A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/bile acid cotransporter 4
    Protein Accession:
    Secondary Accessions:
    • Q8WUZ2

    Protein attributes for SLC10A4 Gene

    437 amino acids
    Molecular mass:
    46504 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A4 Gene

Proteomics data for SLC10A4 Gene at MOPED

Post-translational modifications for SLC10A4 Gene

  • Activated following N-terminal proteolytic cleavage by thrombin and/or proteases.
  • Ubiquitination at Lys 407
  • Glycosylation at Asn 6, Asn 18, Asn 24, Asn 181, and Asn 195
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A4 Gene

Domains & Families for SLC10A4 Gene

Gene Families for SLC10A4 Gene

Protein Domains for SLC10A4 Gene

Suggested Antigen Peptide Sequences for SLC10A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A4: view

Function for SLC10A4 Gene

Molecular function for SLC10A4 Gene

UniProtKB/Swiss-Prot Function:
Transporter for bile acids.
genes like me logo Genes that share phenotypes with SLC10A4: view

Animal Models for SLC10A4 Gene

MGI Knock Outs for SLC10A4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A4

CRISPR Products

miRNA for SLC10A4 Gene

miRTarBase miRNAs that target SLC10A4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC10A4 Gene

Localization for SLC10A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC10A4 Gene COMPARTMENTS Subcellular localization image for SLC10A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC10A4: view

Pathways & Interactions for SLC10A4 Gene

SuperPathways for SLC10A4 Gene

No Data Available

Interacting Proteins for SLC10A4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000273861 for SLC10A4 Gene via STRING

Gene Ontology (GO) - Biological Process for SLC10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with SLC10A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A4 Gene

Drugs & Compounds for SLC10A4 Gene

(1) Additional Compounds for SLC10A4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with SLC10A4: view

Transcripts for SLC10A4 Gene

mRNA/cDNA for SLC10A4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A4 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A4 Gene

No ASD Table

Relevant External Links for SLC10A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC10A4 Gene

mRNA expression in normal human tissues for SLC10A4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A4 Gene

This gene is overexpressed in Brain - Substantia nigra (x12.3), Pituitary (x5.5), and Brain - Hypothalamus (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC10A4 Gene

SOURCE GeneReport for Unigene cluster for SLC10A4 Gene Hs.132591

mRNA Expression by UniProt/SwissProt for SLC10A4 Gene

Tissue specificity: Highly expressed in brain and small intestine, and moderately expressed in colon, heart, prostate, and testis. Very low levels were detected in kidney, liver, ovary, placenta, spleen, and thymus.
genes like me logo Genes that share expression patterns with SLC10A4: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for SLC10A4 Gene

Orthologs for SLC10A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC10A4 35
  • 88.12 (n)
  • 86.44 (a)
SLC10A4 36
  • 84 (a)
(Canis familiaris)
Mammalia SLC10A4 35
  • 88.37 (n)
  • 90.34 (a)
SLC10A4 36
  • 92 (a)
(Mus musculus)
Mammalia Slc10a4 35
  • 83.75 (n)
  • 87.36 (a)
Slc10a4 16
Gm5868 36
  • 92 (a)
Slc10a4 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Slc10a4 35
  • 84.6 (n)
  • 87.13 (a)
(Monodelphis domestica)
Mammalia SLC10A4 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia SLC10A4 36
  • 64 (a)
(Pan troglodytes)
Mammalia SLC10A4 36
  • 97 (a)
(Gallus gallus)
Aves SLC10A4 35
  • 70.02 (n)
  • 71.79 (a)
SLC10A4 36
  • 69 (a)
(Anolis carolinensis)
Reptilia SLC10A4 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a4 35
  • 69.28 (n)
  • 73.19 (a)
(Danio rerio)
Actinopterygii Dr.15580 35
slc10a4 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 36
  • 15 (a)
CG9903 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
-- 36
  • 31 (a)
-- 36
  • 39 (a)
Species with no ortholog for SLC10A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A4 Gene

Gene Tree for SLC10A4 (if available)
Gene Tree for SLC10A4 (if available)

Paralogs for SLC10A4 Gene

Paralogs for SLC10A4 Gene

(3) SIMAP similar genes for SLC10A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC10A4: view

Variants for SLC10A4 Gene

Sequence variations from dbSNP and Humsavar for SLC10A4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6447640 -- 48,481,399(+) ACCAT(A/G)CCCAA upstream-variant-2KB
rs6824075 -- 48,486,933(+) AGTTA(C/T)GCCAT intron-variant
rs6824125 -- 48,487,011(+) TCTGG(A/C)TCTAG intron-variant
rs6829144 -- 48,487,752(+) TTCAG(A/G)AAAAA intron-variant
rs6829716 -- 48,485,797(+) GGCTT(A/C)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A4 Gene

Variant ID Type Subtype PubMed ID
nsv470034 CNV Gain 18288195
nsv829925 CNV Gain+Loss 17160897
dgv5542n71 CNV Loss 21882294

Variation tolerance for SLC10A4 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC10A4 Gene

Disorders for SLC10A4 Gene

Relevant External Links for SLC10A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC10A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A4 Gene

Publications for SLC10A4 Gene

  1. SLC10A4 is a protease-activated transporter that transports bile acids. (PMID: 23589386) Abe T. … Tomioka Y. (J. Biochem. 2013) 3 4 67
  2. Expression, sorting and transport studies for the orphan carrier SLC10A4 in neuronal and non-neuronal cell lines and in Xenopus laevis oocytes. (PMID: 26084360) Schmidt S. … Geyer J. (BMC Neurosci 2015) 3
  3. Distribution of SLC10A4, a synaptic vesicle protein in the human brain, and the association of this protein with Alzheimer's disease-related neuronal degeneration. (PMID: 23948907) Popova S.N. … Alafuzoff I. (J. Alzheimers Dis. 2013) 3
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3
  5. Cloning and molecular characterization of the orphan carrier protein Slc10a4: expression in cholinergic neurons of the rat central nervous system. (PMID: 18355966) Geyer J. … Petzinger E. (Neuroscience 2008) 23

Products for SLC10A4 Gene

Sources for SLC10A4 Gene