SLC10A3 Gene
protein-coding GIFtS: 50
GCID: GC0XM153715
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solute carrier family 10 (sodium/bile acid cotransporter...
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Aliases
for SLC10A3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member31 2 | | P31 2 3 5 | | DXS253E1 2 3 | | Solute Carrier Family 10 Member 32 3 | | P3 Protein2 | | Protein P32 |
Export aliases for SLC10A3 gene to outside databasesPrevious GC identifers: GC0XM151301 GC0XM152183 GC0XM153279 GC0XM153368 GC0XM142292 |
Summaries
for SLC10A3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC10A3:
This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It isthought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinctisoforms.(provided by RefSeq, Dec 2008)
UniProtKB/Swiss-Prot: P3_HUMAN, P09131Function: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that thegene codes for a protein with housekeeping functions
Gene Wiki entry for SLC10A3
|
Genomic Views
for SLC10A3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC10A3 gene promoter:
p53 HOXA3 ATF-2 MIF-1 E47 Arnt GATA-2 PPAR-gamma2 c-Jun RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC10A3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28SLC10A3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM153715: view genomic region
(about GC identifiers)
Start:
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153,715,645 bp from pter |
End:
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153,719,016 bp from pter |
Size:
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3,372 bases |
Orientation:
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minus strand |
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Proteins
for SLC10A3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P3_HUMAN, P09131 (See
protein sequence)Recommended Name: P3 protein Size: 477 amino acids; 50333 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: Q5HY79 Q9BSL2Alternative splicing: 2 isoforms: P09131-1 P09131-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC10A3: NX_P09131
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P09131
SLC10A3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001135863.1 NP_001135864.1 NP_062822.1
ENSEMBL proteins: ENSP00000358663 ENSP00000377211 ENSP00000377212 ENSP00000395702 ENSP00000263512
Human Recombinant Protein Products for SLC10A3:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLC10A3 for ontologies About GeneDecksing
SLC10A3 Antibody Products:
Assay Products for SLC10A3: |
Protein
Domains /
Families
for SLC10A3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC10A3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P09131ProtoNet protein and cluster: P09131 1 Blocks protein family: IPB002657 Bile acid:sodium symporter
UniProtKB/Swiss-Prot: P3_HUMAN, P09131Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family |
Function
for SLC10A3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: P3_HUMAN, P09131Function: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that thegene codes for a protein with housekeeping functions Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008508 | bile acid:sodium symporter activity |
NAS | -- |
SLC10A3 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A3 |
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Pathways & Interactions
for SLC10A3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC10A3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for SLC10A3 (ENSP000002635124) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC10A3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC10A3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC10A3
1 HMDB Compound for SLC10A3 About this table
Search CenterWatch for drugs/clinical trials and news about SLC10A3 / P3
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Transcripts
for SLC10A3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC10A3 gene (3 alternative transcripts): NM_001142391.1 NM_001142392.1 NM_019848.3 Unigene Cluster for SLC10A3: Solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Hs.522826 [show with all ESTs]Unigene Representative Sequence: NM_0198485 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369649 ENST00000393586 ENST00000393587 ENST00000453912 ENST00000263512(uc004flr.3 uc004flq.3 uc004flp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A3 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SLC10A3 (NM_001142391) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC10A3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A3 |
Additional cDNA sequence: BC004966.1 8 DOTS entries: DT.210206 DT.100780148 DT.97820719 DT.97801248 DT.100774911 DT.97775993 DT.100780151 DT.95311913 24/95 AceView cDNA sequences (see all 95): BQ221847 BM981524 CR590776 BU501859 CR591082 NM_019848 CR598961 CR610627 BQ421268 CR622264 BC004966 BE206509 BM755816 BX379235 BE909566 AA379247 BQ009247 AI972634 BX396383 BE312742 BX379234 BX352602 BX401493 BX401684
GeneLoc Exon Structure
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Expression
for SLC10A3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC10A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGTTAGG
About this image
See SLC10A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC10A3
SOURCE GeneReport for Unigene cluster: Hs.522826
SABiosciences Custom PCR Arrays for SLC10A3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC10A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A3 |
Orthologs
for SLC10A3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC10A3 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for SLC10A3 (if available)
TreeFam Gene Tree for SLC10A3 (if available) |
Paralogs
for SLC10A3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC10A3 gene
- SLC10A62 SLC10A12 SLC10A42 SLC10A22 SLC10A52
1 SIMAP similar gene for SLC10A3 using alignment to 2 protein entries: P3_HUMAN (see all proteins):SLC10A5
SLC10A3 for paralogs About GeneDecksing
|
Genomic Variants
for SLC10A3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC10A3 (153715645 - 153719016 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC10A3: --
Locus Specific Mutation Databases (LSDB): SLC10A3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A3 |
|
Disorders
/ Diseases
for SLC10A3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC10A3 for disorders About GeneDecksing
OMIM gene information: 312090
OMIM disorders: --
4  diseases for SLC10A3: About MalaCardswernicke encephalopathy influenza retinitis neuronitis
1 disease from the University of Copenhagen DISEASES database for SLC10A3:Wernicke encephalopathy Export disorders for SLC10A3 gene to outside databases
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Publications
for SLC10A3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC10A3 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SLC10A3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2, 3 Chen E.Y....D'Urso M. (1996)
- CpG islands of the X chromosome are gene associated. (PubMed id 3186440)1, 2 Alcalay M. and Toniolo D. (1988)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
- The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PubMed id 16541252)1 Geyer J....Petzinger E. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SLC10A3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC10A3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC10A3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC10A3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC10A3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC10A3 gene:
Search GeneIP for patents involving SLC10A3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC10A3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC10A3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC10A3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A3 | | | OriGene Protein Over-expression Lysate for SLC10A3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC10A3 | | OriGene 3'-UTR Clone for SLC10A3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC10A3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC10A3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A3 |
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 | | | SLC10A3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A3 |
|  |  |  |  | | | | ThermoFisher Antibodies for SLC10A3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A3 |
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