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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC10A3 Gene

protein-coding   GIFtS: 50
GCID: GC0XM153715

Solute Carrier Family 10, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 10, Member 31 2     Protein P32
P32 3 5     Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 32
DXS253E2 3     Solute Carrier Family 10 Member 33
P3 Protein2     

External Ids:    HGNC: 229791   Entrez Gene: 82732   Ensembl: ENSG000001269037   OMIM: 3120905   UniProtKB: P091313   

Export aliases for SLC10A3 gene to outside databases

Previous GC identifers: GC0XM151301 GC0XM152183 GC0XM153279 GC0XM153368 GC0XM142292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC10A3 Gene:
This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is
thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct
isoforms.(provided by RefSeq, Dec 2008)

GeneCards Summary for SLC10A3 Gene: 
SLC10A3 (solute carrier family 10, member 3) is a protein-coding gene. Diseases associated with SLC10A3 include wernicke encephalopathy, and influenza. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A1.

UniProtKB/Swiss-Prot: P3_HUMAN, P09131
Function: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that
the gene codes for a protein with housekeeping functions

Gene Wiki entry for SLC10A3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC10A3 gene promoter:
         p53   HOXA3   ATF-2   MIF-1   E47   Arnt   GATA-2   PPAR-gamma2   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC10A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC10A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

SLC10A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC10A3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM153715:  view genomic region     (about GC identifiers)

Start:
153,715,645 bp from pter      End:
153,719,016 bp from pter
Size:
3,372 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P3_HUMAN, P09131 (See protein sequence)
Recommended Name: P3 protein  
Size: 477 amino acids; 50333 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Secondary accessions: Q5HY79 Q9BSL2
Alternative splicing: 2 isoforms:  P09131-1   P09131-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC10A3: NX_P09131

Explore proteomics data for SLC10A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09131

  • SLC10A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC10A3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001135863.1  NP_001135864.1  NP_062822.1  

    ENSEMBL proteins: 
     ENSP00000358663   ENSP00000377211   ENSP00000377212   ENSP00000395702   ENSP00000263512  

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    Cloud-Clone Corp. Proteins for SLC10A3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS--

    SLC10A3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/bile acid cotransporter 3 
    SLC10 family of sodium-bile acid co-transporters

    2 InterPro protein domains:
     IPR004710 Bil_ac_transpt
     IPR002657 BilAc/Na_symport

    Graphical View of Domain Structure for InterPro Entry P09131

    ProtoNet protein and cluster: P09131

    1 Blocks protein domain: IPB002657 Bile acid:sodium symporter

    UniProtKB/Swiss-Prot: P3_HUMAN, P09131
    Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family


    SLC10A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P3_HUMAN, P09131
    Function: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that
    the gene codes for a protein with housekeeping functions

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008508bile acid:sodium symporter activity NAS--
         
    SLC10A3 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC10A3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SLC10A3 (ENSP000002635124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    SORBS1ENSP000003551364STRING: ENSP00000355136
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006814sodium ion transport NAS--
    GO:0015711organic anion transport ----
    GO:0032526response to retinoic acid IEA--
    GO:0042221response to chemical stimulus ----

    SLC10A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC10A3 (P3)

    1 HMDB Compound for SLC10A3    About this table
    CompoundSynonyms CAS #PubMed Ids
    SodiumSodium (see all 2)7440-23-5--

    Search CenterWatch for drugs/clinical trials and news about SLC10A3 / P3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC10A3 gene (3 alternative transcripts): 
    NM_001142391.2  NM_001142392.2  NM_019848.4  

    Unigene Cluster for SLC10A3:

    Solute carrier family 10 (sodium/bile acid cotransporter family), member 3
    Hs.522826  [show with all ESTs]
    Unigene Representative Sequence: NM_019848
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369649 ENST00000393586 ENST00000393587 ENST00000453912 ENST00000263512(uc004flr.3 uc004flq.3 uc004flp.3)

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    Additional mRNA sequence: BC004966.1 

    8 DOTS entries:

    DT.210206  DT.100780148  DT.97820719  DT.97801248  DT.100774911  DT.97775993  DT.100780151  DT.95311913 

    24/95 AceView cDNA sequences (see all 95):

    BM755816 BQ421268 BQ221847 BE909566 CR622264 BX379235 BC004966 CR590776 
    BM981524 BE206509 CR598961 BU501859 CR591082 NM_019848 CR610627 BM743153 
    BE312742 BX356032 BX352602 BQ961722 BU732628 BG327309 BX401684 BF312930 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC10A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGTTAGG
    SLC10A3 Expression
    About this image


    See SLC10A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC10A3

    SOURCE GeneReport for Unigene cluster: Hs.522826
        SABiosciences Custom PCR Arrays for SLC10A3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC10A3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc10a31 , 5 solute carrier family 10 (sodium/bile acid cotransporter more1, 5 83.44(n)1
    85.84(a)1
      X (38.00 cM)5
    2146011  NM_001256104.11  NP_001243033.11 
     743692175 
    lizard
    (Anolis carolinensis)
    Reptilia SLC10A36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    1(204790610-204793611)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.97032 Xenopus laevis transcribed sequence with weak similarity more 78.84(n)    BX848794.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc10a31 solute carrier family 10 (sodium/bile acid cotransporter more 65.94(n)
    60.24(a)
      406519  NM_214740.1  NP_999905.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116556
    CG99036
    --
    19(a)
    17(a)
    many ↔ many
    many ↔ many
    X(15347504-15349584)
    X(16433186-16434885)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G10AR.46
    Protein Y71G10AR.4
    14(a)
    1 → many
    IV(2198997-2204545)


    ENSEMBL Gene Tree for SLC10A3 (if available)
    TreeFam Gene Tree for SLC10A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC10A3 gene
    SLC10A12  SLC10A62  SLC10A42  SLC10A22  SLC10A52  
    1 SIMAP similar gene for SLC10A3 using alignment to 2 protein entries:     P3_HUMAN (see all proteins):
    SLC10A5

    SLC10A3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/101 SNPs in SLC10A3 are shown (see all 101)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1135197051,2
    C,F--153583512(+) TAGCAT/CGCGCG 3 -- ds50011Minor allele frequency- C:0.00NA 1
    rs1884147961,2
    --153583602(+) TGGCGC/TCATCT 3 -- ds50010--------
    rs59454341,2
    C,F,H--153583675(+) CCACCC/TCACGC 3 -- ds500112Minor allele frequency- T:0.26NS EA CSA 1687
    rs1926900811,2
    --153584000(+) GAAGGA/GACCCA 3 -- ds50010--------
    rs115503651,2
    C--153584152(-) AAGTTC/TTCATG 3 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs1464065711,2
    C--153584347(+) GCATGG/ACCAAG 6 /A /V mis11Minor allele frequency- A:0.00NA 4448
    rs1997830341,2
    --153584489(+) GATGGA/GTAGCC 6 P S mis10--------
    rs1390149981,2
    C--153584503(+) TGCCTG/ACCAGG 6 /A /V mis11Minor allele frequency- A:0.00NA 4490
    rs344678571,2
    C,F--153584544(-) CTGGGC/TGGCCT 6 G syn13Minor allele frequency- T:0.04NA CSA 4567
    rs353815031,2,4
    C,F--153584579(-) TGCAGG/ATCGTC 6 /I /V mis14Minor allele frequency- A:0.01NA 4588

    HapMap Linkage Disequilibrium report for SLC10A3 (153715645 - 153719016 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC10A3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519042CNV Gain19592680
    esv33199CNV Gain+Loss17666407
    esv33784CNV Gain+Loss17666407


    Locus Specific Mutation Databases (LSDB): SLC10A3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 312090    OMIM disorders: --

    4 diseases for SLC10A3:    About MalaCards
    wernicke encephalopathy    influenza    retinitis    neuronitis


    SLC10A3 for disorders           About GeneDecksing


    Export disorders for SLC10A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC10A3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SLC10A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2, 3 Chen E.Y....D'Urso M. (1996)
    2. CpG islands of the X chromosome are gene associated. (PubMed id 3186440)1, 2 Alcalay M. and Toniolo D. (1988)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
    6. The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. (PubMed id 16541252)1 Geyer J....Petzinger E. (2006)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    8. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8273 HGNC: 22979 AceView: SLC10A3 Ensembl:ENSG00000126903 euGenes: HUgn8273
    ECgene: SLC10A3 H-InvDB: SLC10A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC10A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC10A3 gene:
    Search GeneIP for patents involving SLC10A3

    GeneCards and IP:
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