SLC10A2 Gene

Aliases
for SLC10A2 gene

Previous GC identifers: GC13M102056 GC13M098083 GC13M102532 GC13M101394 GC13M102494 GC13M084288

Summaries
for SLC10A2 gene

Genomic Views
for SLC10A2 gene

RefSeq DNA sequence:

NC_000013.10  NC_018924.1  NT_009952.14  

SwitchGear Promoter luciferase reporter plasmid: SLC10A2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC10A2

SLC10A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M103696:  view genomic region     (about GC identifiers)

Proteins
for SLC10A2 gene

Explore the universe of human proteins at neXtProt for SLC10A2: NX_Q12908

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLC10A2 OriGene Custom Protein Services for SLC10A2
	GenScript Custom Purified and Recombinant Proteins Services for SLC10A2
	Novus Biologicals SLC10A2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC10A2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for SLC10A2
	Novus Biologicals SLC10A2 Antibodies
	Abcam antibodies for SLC10A2
	Uscn Antibodies for SLC10A2
	Search ThermoFisher Antibodies for SLC10A2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC10A2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC10A2

Protein Domains /
Families
for SLC10A2 gene

ProtoNet protein and cluster: Q12908

Function
for SLC10A2 gene

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Slc10a2)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC10A2

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC10A2
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC10A2 (see all 13):
		hsa-miR-579 hsa-miR-3163 hsa-miR-203 hsa-miR-1301 hsa-miR-664 hsa-miR-1305 hsa-miR-1184 hsa-miR-513b
		SwitchGear 3'UTR luciferase reporter plasmid: SLC10A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC10A2 (see all 7) OriGene shRNA RFP: SLC10A2 OriGene siRNA: SLC10A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC10A2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLC10A2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SLC10A2
			Sirion Biotech Customized adenovirus for overexpression of SLC10A2  Sirion Biotech Customized adenovirus for potent knockdown of SLC10A2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC10A2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLC10A2 (NM_000452)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC10A2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC10A2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC10A2
		Search LifeMap BioReagents cell lines for SLC10A2
		Sirion Biotech Customized stable knockdown cell line services for SLC10A2  Sirion Biotech Customized inducible knockdown cell line services for SLC10A2 Sirion Biotech Customized stable overexpressing cell line services for SLC10A2 Sirion Biotech Customized inducible overexpressing cell line services for SLC10A2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A2

Pathways & Interactions
for SLC10A2 gene

	Super-pathway	contained gene-specific pathways
1	Metabolism	Metabolism 1.00 Metabolism of lipids and lipoproteins 0.34
2	Synthesis of bile acids and bile salts	Bile acid and bile salt metabolism 0.70 Recycling of bile acids and salts 0.11
3	Bile secretion	Bile secretion 1.00

4        Reactome Pathways for SLC10A2

	Bile acid and bile salt metabolism
	Metabolism
	Recycling of bile acids and salts
	Metabolism of lipids and lipoproteins

1         Kegg Pathway  (Kegg details for SLC10A2)

Bile secretion

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SLC10A2 gene

Transcripts
for SLC10A2 gene

Expression
for SLC10A2 gene

SLC10A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGAGTTC

About this image

SLC10A2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeVisceral White Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Human kidney epithelial cell spheroids (Kidney spheroids for...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC10A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC10A2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC10A2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC10A2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC10A2

Orthologs
for SLC10A2 gene

Paralogs
for SLC10A2 gene

Paralogs for SLC10A2 gene

SLC10A3²  SLC10A6²  SLC10A1²  SLC10A4²  SLC10A5²  

4 SIMAP similar genes for SLC10A2 using alignment to 1 protein entry:     NTCP2_HUMAN:

SLC10A6    SLC10A1    SLC10A4    SLC10A5

SLC10A2 for paralogs           About GeneDecksing

Genomic Variants
for SLC10A2 gene

10/865 NCBI SNPs in SLC10A2 are shown (see all 865)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs725475051,2	C,F	pathogenic	84294052(-)	TGAAAA/C/TGGGGA	3	K T M	mis1		1		NA	4550
rs1151545201,2	C,F	--	84288907(+)	TGGCAT/CCCAGG	1	--	ut31		1		WA	118
rs793092661,2	C,F	--	84289027(+)	GACTGT/CAAATC	1	--	ut31		1		WA	118
rs1845855111,2	C	--	84289193(+)	TTGCAG/TAAAAA	1	--	ut31		0	--	--	--	--
rs1886054371,2	C	--	84289345(+)	AAACAC/GTTGAA	1	--	ut31		0	--	--	--	--
rs797319041,2		--	84289535(+)	TGCTAC/TCGTAT	1	--	ut31		1		WA	118
rs412816761,2	C,F	--	84289608(+)	TGGTGG/AGGCCC	1	--	ut31		2		WA NA	238
rs1418012621,2	C	--	84289634(+)	CCTGGA/GACACG	1	--	ut31		0	--	--	--	--
rs1505575401,2	C	--	84289700(+)	TCTTCG/TTATAC	1	--	ut31		0	--	--	--	--
rs32167811,2	C	--	84289737(-)	AAATGCTTAA/-          CTAGA	1	--	ut31		1		NA	2

HapMap Linkage Disequilibrium report for SLC10A2 (103696348 - 103719196 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC10A2
     2 CNVs: 9721 66534
Human Gene Mutation Database (HGMD): SLC10A2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC10A2

DNA2.0 Custom Variant and Variant Library Synthesis for SLC10A2

Disorders / Diseases
for SLC10A2 gene

20/34 diseases for SLC10A2

10/11 Novoseek disease relationships for SLC10A2 gene (see all 11)    About this table

Publications
for SLC10A2 gene

PubMed articles for SLC10A2 gene, integrated from 9 sources (see all 143): (articles sorted by number of sources associating them with SLC10A2)

Utopia: connect your pdf to the dynamic world of online information

1. Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2). (PubMed id 15350125)^{1, 2, 9} Zhang E.Y.... Swaan P.W. (2004)
2. An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas. (PubMed id 11535543)^{1, 4, 9} Wang W....Haile R.W. (2001)
3. Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption. (PubMed id 11589382)^{1, 2, 9} Montagnani M.... Qvist P. (2001)
4. Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. (PubMed id 11742882)^{1, 2, 9} Love M.W....Dawson P.A. (2001)
5. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). (PubMed id 9109432)^{1, 2, 9} Oelkers P.... Dawson P.A. (1997)
6. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. (PubMed id 7592981)^{1, 2, 9} Wong M.H.... Dawson P.A. (1995)
7. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. (PubMed id 9458785)^{1, 7, 9} Craddock A.L....Dawson P.A. (1998)
8. Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33. (PubMed id 8661017)^{1, 3, 9} Wong M.H....Dawson P.A. (1996)
9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
10. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)^{1, 2} Chumakov I.... Cohen D. (2002)

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