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SLC10A1 Gene

protein-coding   GIFtS: 60
GCID: GC14M070242

Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter),...

  See SLC10A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 11 2     Growth-Inhibiting Protein 292
Cell Growth-Inhibiting Gene 29 Protein2 3     Na/Taurocholate Cotransporting Polypeptide2
Sodium/Taurocholate Cotransporting Polypeptide2 3     Sodium/Bile Acid Cotransporter2
Solute Carrier Family 10 Member 12 3     Sodium/Taurocholate Cotransporter2
NTCP2 3     Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 12
Na(+)/Bile Acid Cotransporter2 3     NTCP15
Na(+)/Taurocholate Transport Protein2 3     

External Ids:    HGNC: 109051   Entrez Gene: 65542   Ensembl: ENSG000001006527   OMIM: 1823965   UniProtKB: Q149733   

Export aliases for SLC10A1 gene to outside databases

Previous GC identifers: GC14M067747 GC14M064038 GC14M068232 GC14M069312 GC14M050411


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC10A1 Gene:
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane
glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are
involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell
localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific
sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of
hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for
cholesterol homeostasis. (provided by RefSeq, Oct 2011)

GeneCards Summary for SLC10A1 Gene:
SLC10A1 (solute carrier family 10 (sodium/bile acid cotransporter), member 1) is a protein-coding gene. Diseases associated with SLC10A1 include biliary atresia, and erythropoietic protoporphyria. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A3.

UniProtKB/Swiss-Prot: NTCP_HUMAN, Q14973
Function: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various
non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium

Gene Wiki entry for SLC10A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC10A1 gene promoter:
         Max1   c-Fos   PPAR-gamma1   AP-1   ATF-2   STAT3   c-Jun   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC10A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC10A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

SLC10A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC10A1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M070242:  view genomic region     (about GC identifiers)

Start:
70,242,134 bp from pter      End:
70,264,006 bp from pter
Size:
21,873 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NTCP_HUMAN, Q14973 (See protein sequence)
Recommended Name: Sodium/bile acid cotransporter  
Size: 349 amino acids; 38119 Da
Secondary accessions: B9EGB6 Q2TU29

Explore the universe of human proteins at neXtProt for SLC10A1: NX_Q14973

Explore proteomics data for SLC10A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn11, Asn117, Asn336
  • Modification sites at PhosphoSitePlus

  • See SLC10A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003040.1  
    ENSEMBL proteins: 
     ENSP00000216540  
    Reactome Protein details: Q14973

    SLC10A1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Sodium/bile acid cotransporter 1
    SLC10 family of sodium-bile acid co-transporters

    2 InterPro protein domains:
     IPR004710 Bil_ac_transpt
     IPR002657 BilAc/Na_symport

    Graphical View of Domain Structure for InterPro Entry Q14973

    ProtoNet protein and cluster: Q14973

    1 Blocks protein domain: IPB002657 Bile acid:sodium symporter

    UniProtKB/Swiss-Prot: NTCP_HUMAN, Q14973
    Similarity: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family


    Find genes that share domains with SLC10A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTCP_HUMAN, Q14973
    Function: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various
    non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium

         Genatlas biochemistry entry for SLC10A1:
    solute carrier family 10,38kDa,(sodium/taurocholate cotransport),member 1,hepatic

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008508bile acid:sodium symporter activity IEA--
    GO:0015125bile acid transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC10A1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC10A1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTCP_HUMAN, Q14973: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8132774
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--

    Find genes that share ontologies with SLC10A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC10A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.73
    Recycling of bile acids and salts0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Hepatic ABC Transporters
    Hepatic ABC Transporters0.41
    4Drug Induction of Bile Acid Pathway
    Drug Induction of Bile Acid Pathway
    5Bile secretion
    Bile secretion


    Find genes that share SuperPaths with SLC10A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC10A1
        Hepatic ABC Transporters

    1 BioSystems Pathway for SLC10A1
        Drug Induction of Bile Acid Pathway


    1 Reactome Pathway for SLC10A1
        Recycling of bile acids and salts


    1 Kegg Pathway  (Kegg details for SLC10A1):
        Bile secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC10A1: 
              Drug Transporters in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC10A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SLC10A1 (ENSP000002165404) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB11ENSP000002638174STRING: ENSP00000263817
    ABCC3ENSP000002852384STRING: ENSP00000285238
    ALBENSP000002958974STRING: ENSP00000295897
    FABP6ENSP000003775494STRING: ENSP00000377549
    NIP7ENSP000002549404STRING: ENSP00000254940
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8132774
    GO:0006814sodium ion transport ----
    GO:0008206bile acid metabolic process TAS--
    GO:0015711organic anion transport ----
    GO:0015721bile acid and bile salt transport TAS--

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC10A1 (NTCP)

    Selected HMDB Compounds for SLC10A1 (see all 86)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acidChenodeoxycholic acid 3-glucuronide (see all 3)58814-71-4--
    1,3,12-Trihydroxycholan-24-oic acid1,3,12-Trihydroxycholan-24-oate (see all 6)63266-91-1--
    1,3,7,12-Tetrahydroxycholan-24-oic acid1,3,7,12-Tetrahydroxycholan-24-oate (see all 10)63266-89-7--
    12-Ketodeoxycholic acid12-Dehydrodeoxycholate (see all 20)5130-29-0--
    12a-Hydroxy-3-oxocholadienic acid12a-Hydroxy-3-oxo-4,6-choladien-24-oate (see all 8)13535-96-1--
    12b-Hydroxy-5b-cholanoic acid12b-Hydroxy-5b-cholanic acid (see all 9)15173-23-6--
    1b,3a,12a-Trihydroxy-5b-cholanoic acid1,3,12-trihydroxy-(5b)-Cholan-24-oate (see all 6)80434-32-8--
    1b,3a,7a-Trihydroxy-5b-cholanoic acid1 beta,3a,7a-Trihydroxy-5b-cholanoate (see all 18)99598-04-6--
    1b-Hydroxycholic acid1b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 5)80875-94-1--
    2b,3a,7a,12a-Tetrahydroxy-5b-cholanoic acid2b,3a,7a,12a-Tetrahydroxy-5b-cholan-24-oate (see all 7)60696-60-8--

    Selected DrugBank Compounds for SLC10A1 (see all 16)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4transportersubstrate inhibitor15297262 1961729 9486191 12842829 8738419
    Taurocholic Acid-- 81-24-3transportersubstrate15297262 12842829 12518026 8166278
    BumetanideBumetanida [INN-Spanish] (see all 2)28395-03-1transportersubstrate inhibitor1961729 8738419
    Ursodeoxycholic acid(3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid (see all 18)128-13-2transportersubstrate inhibitor15297262 8166278
    Conjugated EstrogensEstrogens (see all 10)438-67-5transporterinhibitor9486191
    CyclosporineCiclosporin (see all 4)59865-13-3transporterinhibitor9486191
    Deoxycholic Acid-- 83-44-3transportersubstrate12842829
    Ethinyl Estradiol17 alpha-Ethinylestradiol (see all 17)57-63-6transporterinducer10611165
    Glycochenodeoxycholic Acid-- 640-79-9transportersubstrate15297262
    IndomethacinIMN (see all 9)53-86-1transportersubstrate10870987

    3 IUPHAR Ligands for SLC10A1 (Sodium/bile acid cotransporter 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    propranolol
    InhibitorInhibition10565843
    cyclosporin A
    InhibitorInhibition10565843
    chenodeoxycholyl-Nepsilon-nitrobenzoxadiazol-lysine
    NoneNone9856990

    6 Novoseek inferred chemical compound relationships for SLC10A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    taurocholate 89.2 36 16760228 (4), 16027164 (2), 10565843 (2), 9425937 (2) (see all 20)
    oatp 79.7 11 17724432 (4), 15345472 (1), 18327154 (1)
    sodium 35 10 15932064 (2), 18355966 (1), 9645505 (1)
    cholesterol 23.9 2 9645505 (1), 17635184 (1)
    phospholipid 19.7 1 12763363 (1)
    cyclosporin a 1.76 1 10565843 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC10A1 gene: 
    NM_003049.3  

    Unigene Cluster for SLC10A1:

    Solute carrier family 10 (sodium/bile acid cotransporter family), member 1
    Hs.952  [show with all ESTs]
    Unigene Representative Sequence: NM_003049
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000216540(uc001xlr.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC10A1

    Additional mRNA sequence: 

    AK314028.1 AY544127.1 BC069799.1 BC069822.1 BC074724.2 BC126298.1 BC136355.1 JQ814895.1 
    L21893.1 

    5 DOTS entries:

    DT.409866  DT.97788355  DT.95169746  DT.95169772  DT.100685567 

    19 AceView cDNA sequences:

    CB157583 BC069799 AL712508 L21893 BC074724 CB123014 CB154117 BC069822 
    NM_003049 CB164333 AA701183 CB162482 T68568 T68645 N70966 BF356838 
    W01479 T67771 AV764080 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC10A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGACTGGAT
    SLC10A1 Expression
    About this image

    SLC10A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC10A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.952
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC10A1: 
              Drug Transporters in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC10A1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc10a11 , 5 solute carrier family 10 (sodium/bile acid cotransporter more1, 5 81.63(n)1
    78.13(a)1
      12 (37.21 cM)5
    204931  NM_001177561.11  NP_001171032.11 
     809531855 
    chicken
    (Gallus gallus)
    Aves SLC10A16
    solute carrier family 10 (sodium/bile acid cotrans...
    47(a)
    1 ↔ 1
    5(27145874-27148416)
    lizard
    (Anolis carolinensis)
    Reptilia SLC10A16
    solute carrier family 10 (sodium/bile acid cotrans...
    56(a)
    1 ↔ 1
    GL343318.1(712891-730153)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004895801 sodium/bile acid cotransporter-like 58.54(n)
    53.71(a)
      100489580  XM_002936898.2  XP_002936944.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slc10a11 solute carrier family 10 (sodium/bile acid cotransporter more 60.37(n)
    52.12(a)
      562260  XM_685653.4  XP_690745.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116556
    CG99036
    --
    15(a)
    14(a)
    many ↔ many
    many ↔ many
    X(15347504-15349584)
    X(16433186-16434885)
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G10AR.46
    Protein Y71G10AR.4 (Y71G10AR.4) mRNA, complete cds...
    17(a)
    1 → many
    IV(2198997-2208831) WBGene00044650


    ENSEMBL Gene Tree for SLC10A1 (if available)
    TreeFam Gene Tree for SLC10A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC10A1 gene
    SLC10A32  SLC10A62  SLC10A42  SLC10A22  SLC10A52  
    3 SIMAP similar genes for SLC10A1 using alignment to 2 protein entries:     NTCP_HUMAN (see all proteins):
    SLC10A6    SLC10A2    SLC10A4

    Find genes that share paralogs with SLC10A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC10A1 (see all 739)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785786211,2
    F--70242072(+) GCATGA/GTTGAC 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1479937011,2
    C--70242261(+) TGGGGA/GCGCCT 1 -- ds50010--------
    rs760127671,2
    C,F--70242643(+) TATTTG/AAGTAA 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1416724911,2
    C--70242654(+) TGGGTA/TAAACA 1 -- ut310--------
    rs1501239201,2
    --70242708(+) ATCAGA/GCACTT 1 -- ut310--------
    rs1387425461,2
    C--70242723(+) AGATCA/CCAGCA 1 -- ut310--------
    rs1427914771,2
    C--70242740(+) AGATTC/TGGTTT 1 -- ut310--------
    rs1877292861,2
    --70242744(+) TCGGTG/TTCTGG 1 -- ut310--------
    rs1910865611,2
    C--70242755(+) TTTCAG/TAGAGT 1 -- ut310--------
    rs1821386951,2
    --70242838(+) GACACC/TCTGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC10A1 (70242134 - 70264006 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC10A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv456336CNV Gain19166990

    Human Gene Mutation Database (HGMD): SLC10A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC10A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC10A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182396    OMIM disorders: --

    4 diseases for SLC10A1:    
    About MalaCards
    biliary atresia    erythropoietic protoporphyria    hepatoblastoma    primary biliary cirrhosis

    1 disease from the University of Copenhagen DISEASES database for SLC10A1:
    Cholestasis

    Find genes that share disorders with SLC10A1           About GenesLikeMe

    4 Novoseek inferred disease relationships for SLC10A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholestasis 72.1 4 9141436 (1), 18327154 (1), 15205115 (1)
    biliary atresia 57 3 15922475 (2), 9141436 (1)
    hepatoblastoma 46.4 2 14598021 (1)
    liver diseases 38.3 2 9141436 (2)

    Genetic Association Database (GAD): SLC10A1
    Human Genome Epidemiology (HuGE) Navigator: SLC10A1 (8 documents)

    Export disorders for SLC10A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC10A1 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with SLC10A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. (PubMed id 8132774)1, 2, 3 Hagenbuch B. and Meier P.J. (J. Clin. Invest. 1994)
    2. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    5. Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. (PubMed id 20031551)1, 4 Voora D....Ginsburg G.S. (Circ Cardiovasc Genet 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp. (PubMed id 16027164)1, 9 Anwer M.S....Ananthanarayanan M. (J. Biol. Chem. 2005)
    8. Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene. (PubMed id 14701722)1, 9 Jung D....Kullak-Ublick G.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2004)
    9. Structural and functional characterization of liver cell-specific activity of the human sodium/taurocholate cotransporter. (PubMed id 11031103)1, 9 Shiao T.... Simon F.R. (Genomics 2000)
    10. Developmental expression of canalicular transporter genes in human liver. (PubMed id 15922475)1, 9 Chen H.L....Chang M.H. (J. Hepatol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6554 HGNC: 10905 AceView: SLC10A1 Ensembl:ENSG00000100652 euGenes: HUgn6554
    ECgene: SLC10A1 Kegg: 6554 H-InvDB: SLC10A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC10A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC10A1 gene:
    Search GeneIP for patents involving SLC10A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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