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Aliases for SLC10A1 Gene

Aliases for SLC10A1 Gene

  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 1 2 3
  • Sodium/Taurocholate Cotransporting Polypeptide 3 4
  • Cell Growth-Inhibiting Gene 29 Protein 3 4
  • Na(+)/Taurocholate Transport Protein 3 4
  • Solute Carrier Family 10 Member 1 3 4
  • Na(+)/Bile Acid Cotransporter 3 4
  • NTCP 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 1 3
  • Na/Taurocholate Cotransporting Polypeptide 3
  • Sodium/Taurocholate Cotransporter 3
  • Sodium/Bile Acid Cotransporter 3
  • Growth-Inhibiting Protein 29 3
  • NTCP1 6

External Ids for SLC10A1 Gene

Summaries for SLC10A1 Gene

Entrez Gene Summary for SLC10A1 Gene

  • The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

GeneCards Summary for SLC10A1 Gene

SLC10A1 (Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 1) is a Protein Coding gene. Diseases associated with SLC10A1 include biliary atresia and hepatoblastoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A6.

UniProtKB/Swiss-Prot for SLC10A1 Gene

  • The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium

Gene Wiki entry for SLC10A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A1 Gene

Genomics for SLC10A1 Gene

Genomic Location for SLC10A1 Gene

Start:
69,775,417 bp from pter
End:
69,797,289 bp from pter
Size:
21,873 bases
Orientation:
Minus strand

Genomic View for SLC10A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC10A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A1 Gene

Regulatory Elements for SLC10A1 Gene

Proteins for SLC10A1 Gene

  • Protein details for SLC10A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14973-NTCP_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter
    Protein Accession:
    Q14973
    Secondary Accessions:
    • B9EGB6
    • Q2TU29

    Protein attributes for SLC10A1 Gene

    Size:
    349 amino acids
    Molecular mass:
    38119 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC10A1 Gene

Proteomics data for SLC10A1 Gene at MOPED

Post-translational modifications for SLC10A1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn5, Asn11, Asn117, and Asn336

Other Protein References for SLC10A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A1 Gene

Domains for SLC10A1 Gene

Gene Families for SLC10A1 Gene

Protein Domains for SLC10A1 Gene

UniProtKB/Swiss-Prot:

NTCP_HUMAN
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.:
    • Q14973
genes like me logo Genes that share domains with SLC10A1: view

Function for SLC10A1 Gene

Molecular function for SLC10A1 Gene

GENATLAS Biochemistry: solute carrier family 10,38kDa,(sodium/taurocholate cotransport),member 1,hepatic
UniProtKB/Swiss-Prot Function: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium

Gene Ontology (GO) - Molecular Function for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity IEA --
GO:0015125 bile acid transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC10A1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC10A1 Gene

Localization for SLC10A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC10A1 Gene COMPARTMENTS Subcellular localization image for SLC10A1 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8132774
GO:0016020 membrane --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC10A1: view

Pathways for SLC10A1 Gene

genes like me logo Genes that share pathways with SLC10A1: view

Pathways by source for SLC10A1 Gene

1 Qiagen pathway for SLC10A1 Gene
1 BioSystems pathway for SLC10A1 Gene

Interacting Proteins for SLC10A1 Gene

Gene Ontology (GO) - Biological Process for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8132774
GO:0006814 sodium ion transport IEA --
GO:0008206 bile acid metabolic process TAS --
GO:0015721 bile acid and bile salt transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SLC10A1: view

Compounds for SLC10A1 Gene

(86) HMDB Compounds for SLC10A1 Gene

Compound Synonyms Cas Number PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanic acid
15173-23-6

(16) Drugbank Compounds for SLC10A1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bumetanide
  • Bumetanida [INN-Spanish]
28395-03-1 transporter substrate inhibitor
Cholic Acid
81-25-4 transporter substrate inhibitor
Conjugated Estrogens
  • Estrogens
438-67-5 transporter inhibitor
Cyclosporine
  • Ciclosporin
59865-13-3 transporter inhibitor
Deoxycholic Acid
83-44-3 transporter substrate

(3) IUPHAR Ligand for SLC10A1 Gene

Ligand Type Action Affinity Pubmed IDs
propranolol Inhibitor Inhibition
cyclosporin A Inhibitor Inhibition
chenodeoxycholyl-Nepsilon-nitrobenzoxadiazol-lysine None None

(6) Novoseek inferred chemical compound relationships for SLC10A1 Gene

Compound -log(P) Hits PubMed IDs
taurocholate 89.2 27
oatp 79.7 6
sodium 35 4
cholesterol 23.9 2
phospholipid 19.7 1
genes like me logo Genes that share compounds with SLC10A1: view

Transcripts for SLC10A1 Gene

mRNA/cDNA for SLC10A1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A1 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A1 Gene

No ASD Table

Relevant External Links for SLC10A1 Gene

GeneLoc Exon Structure for
SLC10A1
ECgene alternative splicing isoforms for
SLC10A1

Expression for SLC10A1 Gene

mRNA expression in normal human tissues for SLC10A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A1 Gene

This gene is overexpressed in Liver (51.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC10A1 Gene

SOURCE GeneReport for Unigene cluster for SLC10A1 Gene Hs.952

genes like me logo Genes that share expressions with SLC10A1: view

Orthologs for SLC10A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A1 36
  • 99.14 (n)
  • 99.14 (a)
SLC10A1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC10A1 36
  • 85.99 (n)
  • 83.48 (a)
SLC10A1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC10A1 36
  • 86.82 (n)
  • 85.67 (a)
SLC10A1 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc10a1 36
  • 81.63 (n)
  • 78.13 (a)
Slc10a1 16
Slc10a1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC10A1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc10a1 36
  • 82.46 (n)
  • 78.65 (a)
chicken
(Gallus gallus)
Aves SLC10A1 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC10A1 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489580 36
  • 58.54 (n)
  • 53.71 (a)
zebrafish
(Danio rerio)
Actinopterygii slc10a1 36
  • 60.37 (n)
  • 52.12 (a)
slc10a1 37
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11655 37
  • 15 (a)
ManyToMany
CG9903 37
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for SLC10A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A1 Gene

ENSEMBL:
Gene Tree for SLC10A1 (if available)
TreeFam:
Gene Tree for SLC10A1 (if available)

Paralogs for SLC10A1 Gene

Paralogs for SLC10A1 Gene

Selected SIMAP similar genes for SLC10A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC10A1: view

Variants for SLC10A1 Gene

Sequence variations from dbSNP and Humsavar for SLC10A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs943276 -- 69,794,213(+) GGTTT(A/G)CACAT intron-variant
rs943277 -- 69,794,608(+) AAGTT(A/G)TCCCA intron-variant
rs2296651 - 69,778,476(+) TGGTG(A/G)AACAG reference, missense
rs2332167 -- 69,787,610(+) GGTAG(A/G)CATGT intron-variant
rs3784152 -- 69,781,051(+) GATCC(A/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A1 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV Gain 19166990

Relevant External Links for SLC10A1 Gene

HapMap Linkage Disequilibrium report
SLC10A1
Human Gene Mutation Database (HGMD)
SLC10A1

Disorders for SLC10A1 Gene

(1) University of Copenhagen DISEASES for SLC10A1 Gene

(4) Novoseek inferred disease relationships for SLC10A1 Gene

Disease -log(P) Hits PubMed IDs
cholestasis 72.1 3
biliary atresia 57 3
hepatoblastoma 46.4 1
liver diseases 38.3 2

Relevant External Links for SLC10A1

Genetic Association Database (GAD)
SLC10A1
Human Genome Epidemiology (HuGE) Navigator
SLC10A1
genes like me logo Genes that share disorders with SLC10A1: view

No data available for UniProtKB/Swiss-Prot for SLC10A1 Gene

Publications for SLC10A1 Gene

  1. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. (PMID: 8132774) Hagenbuch B. … Meier P.J. (J. Clin. Invest. 1994) 2 3 4
  2. The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells. (PMID: 17635184) Dias V. … Ribeiro V. (Fundam. Clin. Pharmacol. 2007) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Developmental expression of canalicular transporter genes in human liver. (PMID: 15922475) Chen H.L. … Chang M.H. (J. Hepatol. 2005) 3 23
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 49

Products for SLC10A1 Gene

Sources for SLC10A1 Gene

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