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Aliases for SLC10A1 Gene

Aliases for SLC10A1 Gene

  • Solute Carrier Family 10 Member 1 2 3 4 5
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 1 2 3
  • Sodium/Taurocholate Cotransporting Polypeptide 3 4
  • Cell Growth-Inhibiting Gene 29 Protein 3 4
  • Na(+)/Taurocholate Transport Protein 3 4
  • Na(+)/Bile Acid Cotransporter 3 4
  • NTCP 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 1 3
  • Na+/Taurocholate Cotransporting Polypeptide 2
  • Na/Taurocholate Cotransporting Polypeptide 3
  • Sodium/Taurocholate Cotransporter 3
  • Sodium/Bile Acid Cotransporter 3
  • Growth-Inhibiting Protein 29 3

External Ids for SLC10A1 Gene

Previous GeneCards Identifiers for SLC10A1 Gene

  • GC14M067747
  • GC14M064038
  • GC14M068232
  • GC14M069312
  • GC14M070242
  • GC14M050411

Summaries for SLC10A1 Gene

Entrez Gene Summary for SLC10A1 Gene

  • The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

GeneCards Summary for SLC10A1 Gene

SLC10A1 (Solute Carrier Family 10 Member 1) is a Protein Coding gene. Diseases associated with SLC10A1 include Hepatitis B and Hepatitis. Among its related pathways are Hepatic ABC Transporters and Drug Induction of Bile Acid Pathway. GO annotations related to this gene include bile acid:sodium symporter activity and bile acid transmembrane transporter activity. An important paralog of this gene is SLC10A4.

UniProtKB/Swiss-Prot for SLC10A1 Gene

  • The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

  • (Microbial infection) Acts as a receptor for hepatitis B virus.

Gene Wiki entry for SLC10A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A1 Gene

Genomics for SLC10A1 Gene

Regulatory Elements for SLC10A1 Gene

Enhancers for SLC10A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC10A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC10A1 Gene

69,775,417 bp from pter
69,797,289 bp from pter
21,873 bases
Minus strand

Genomic View for SLC10A1 Gene

Genes around SLC10A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A1 Gene

Proteins for SLC10A1 Gene

  • Protein details for SLC10A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/bile acid cotransporter
    Protein Accession:
    Secondary Accessions:
    • B9EGB6
    • Q2TU29

    Protein attributes for SLC10A1 Gene

    349 amino acids
    Molecular mass:
    38119 Da
    Quaternary structure:
    • (Microbial infection) Interacts with hepatitis B virus large envelope protein.

neXtProt entry for SLC10A1 Gene

Post-translational modifications for SLC10A1 Gene

  • Glycosylation at Asn 5, Asn 11, Asn 117, and Asn 336
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A1 Gene

Domains & Families for SLC10A1 Gene

Gene Families for SLC10A1 Gene

Protein Domains for SLC10A1 Gene

Suggested Antigen Peptide Sequences for SLC10A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A1: view

Function for SLC10A1 Gene

Molecular function for SLC10A1 Gene

GENATLAS Biochemistry:
solute carrier family 10,38kDa,(sodium/taurocholate cotransport),member 1,hepatic
UniProtKB/Swiss-Prot Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis B virus.

Gene Ontology (GO) - Molecular Function for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0008508 bile acid:sodium symporter activity IEA,TAS --
GO:0015125 bile acid transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A1: view
genes like me logo Genes that share phenotypes with SLC10A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A1

CRISPR Products

miRNA for SLC10A1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A1 Gene

Localization for SLC10A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC10A1 Gene COMPARTMENTS Subcellular localization image for SLC10A1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8132774
GO:0016020 membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC10A1: view

Pathways & Interactions for SLC10A1 Gene

genes like me logo Genes that share pathways with SLC10A1: view

Pathways by source for SLC10A1 Gene

1 KEGG pathway for SLC10A1 Gene
1 Qiagen pathway for SLC10A1 Gene

Interacting Proteins for SLC10A1 Gene

Gene Ontology (GO) - Biological Process for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8132774
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport IEA,TAS --
GO:0046718 viral entry into host cell IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A1: view

No data available for SIGNOR curated interactions for SLC10A1 Gene

Drugs & Compounds for SLC10A1 Gene

(24) Drugs for SLC10A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, inhibitor, Transporter Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Bumetanide Approved Pharma Agonist, Transporter, substrate, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 15
cholic acid Approved Pharma Full agonist, Agonist, Transporter, substrate, inhibitor 0
deoxycholic acid Approved Pharma Antagonist, Transporter, substrate 39
Ethinyl Estradiol Approved Pharma Transporter, inducer Oral contraceptive 704

(84) Additional Compounds for SLC10A1 Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Sodium
  • Sodium ion
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
genes like me logo Genes that share compounds with SLC10A1: view

Transcripts for SLC10A1 Gene

mRNA/cDNA for SLC10A1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC10A1 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A1 Gene

No ASD Table

Relevant External Links for SLC10A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC10A1 Gene

mRNA expression in normal human tissues for SLC10A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A1 Gene

This gene is overexpressed in Liver (x51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC10A1 Gene

Protein tissue co-expression partners for SLC10A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC10A1 Gene:


SOURCE GeneReport for Unigene cluster for SLC10A1 Gene:

genes like me logo Genes that share expression patterns with SLC10A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC10A1 Gene

Orthologs for SLC10A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC10A1 34
  • 85.99 (n)
  • 83.48 (a)
SLC10A1 35
  • 78 (a)
(Canis familiaris)
Mammalia SLC10A1 34
  • 86.82 (n)
  • 85.67 (a)
SLC10A1 35
  • 76 (a)
(Mus musculus)
Mammalia Slc10a1 34
  • 81.63 (n)
  • 78.13 (a)
Slc10a1 16
Slc10a1 35
  • 74 (a)
(Pan troglodytes)
Mammalia SLC10A1 34
  • 99.14 (n)
  • 99.14 (a)
SLC10A1 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc10a1 34
  • 82.46 (n)
  • 78.65 (a)
(Monodelphis domestica)
Mammalia SLC10A1 35
  • 75 (a)
(Gallus gallus)
Aves SLC10A1 35
  • 47 (a)
(Anolis carolinensis)
Reptilia SLC10A1 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489580 34
  • 58.54 (n)
  • 53.71 (a)
(Danio rerio)
Actinopterygii slc10a1 34
  • 60.37 (n)
  • 52.12 (a)
slc10a1 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 35
  • 15 (a)
CG9903 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
Species where no ortholog for SLC10A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A1 Gene

Gene Tree for SLC10A1 (if available)
Gene Tree for SLC10A1 (if available)

Paralogs for SLC10A1 Gene

Paralogs for SLC10A1 Gene

(3) SIMAP similar genes for SLC10A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC10A1: view

Variants for SLC10A1 Gene

Sequence variations from dbSNP and Humsavar for SLC10A1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2296651 - 69,778,476(+) TGGTG(A/G)AACAG reference, missense
rs8020504 -- 69,790,895(+) atTTT(C/T)CATTA intron-variant
rs8022592 -- 69,787,384(+) TTAAC(A/C)ATATA intron-variant
rs9323529 -- 69,777,096(+) GTCAC(G/T)TCAGG intron-variant
rs9944036 -- 69,789,970(+) GCAAG(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A1 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV gain 19166990
nsv565007 CNV gain 21841781

Variation tolerance for SLC10A1 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC10A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A1 Gene

Disorders for SLC10A1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC10A1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
  • acute and subacute liver necrosis
biliary atresia
  • atresia of bile duct
bile duct disease
  • bile duct disorder nos
extrahepatic cholestasis
  • extrahepatic biliary stasis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC10A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC10A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC10A1 Gene

Publications for SLC10A1 Gene

  1. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. (PMID: 8132774) Hagenbuch B. … Meier P.J. (J. Clin. Invest. 1994) 2 3 4 65
  2. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. (PMID: 23150796) Yan H. … Li W. (Elife 2012) 3 4 65
  3. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts K.E. … Fallon M.B. (Gastroenterology 2010) 3 46 65
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 65
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 65

Products for SLC10A1 Gene

Sources for SLC10A1 Gene

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