Aliases for SLC10A1 Gene
External Ids for SLC10A1 Gene
Previous GeneCards Identifiers for SLC10A1 Gene
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
GeneCards Summary for SLC10A1 Gene
SLC10A1 (Solute Carrier Family 10 Member 1) is a Protein Coding gene. Diseases associated with SLC10A1 include Biliary Atresia and Hepatitis B. Among its related pathways are Farnesoid X Receptor Pathway and Bile secretion. GO annotations related to this gene include bile acid:sodium symporter activity and bile acid transmembrane transporter activity. An important paralog of this gene is SLC10A4.
UniProtKB/Swiss-Prot for SLC10A1 Gene
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
(Microbial infection) Acts as a receptor for hepatitis B virus.