Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLBP Gene

protein-coding GIFtS: 55
GCID: GC04M001694

stem-loop binding protein

(Previous name: stem-loop (histone) binding protein )

Explore 6 diseases affiliated with
SLBP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Stem-Loop Binding Protein¹ ²		Hairpin Binding Protein, Histone²
HBP¹ ² ³ ⁵		Histone Binding Protein²
Stem-Loop (Histone) Binding Protein¹ ²		Histone RNA Hairpin-Binding Protein²
Histone Stem-Loop-Binding Protein² ³		Histone Stem-Loop Binding Protein²

External Ids:	HGNC: 10904¹	Entrez Gene: 7884²	Ensembl: ENSG00000163950⁷	OMIM: 602422⁵	UniProtKB: Q14493³

Export aliases for SLBP gene to outside databases

Previous GC identifers: GC04M001686 GC04M001656 GC04M001661 GC04M001664 GC04M001637

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLBP:

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs

do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop

structure is essential for efficient processing but this structure also controls the transport, translation and

stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold

during the latter part of G1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493

Function: RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of

replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex

between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE).

Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation

machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression.

Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds

to the 5' side of the stem-loop structure of histone pre-mRNAs

Gene Wiki entry for SLBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_006051.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLBP gene promoter:
AML1a p53 HTF Nkx2-5 NF-E2 p45 NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLBP promoter sequence

Search SABiosciences Chromatin IP Primers for SLBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3

SLBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLBP gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M001694: view genomic region (about GC identifiers)

Start:	1,694,527 bp from pter	End:	1,714,282 bp from pter
Size:	19,756 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493 (See protein sequence)

Recommended Name: Histone RNA hairpin-binding protein

Size: 270 amino acids; 31286 Da

Subunit: Monomer. SLBP/pre-mRNA complex interacts with ZNF473. Interacts with the Importin alpha/Importin beta

receptor, LSM1, MIF4GD, TNPO3 and UPF1. Interaction with LSM1 occurs when histone mRNA is being rapidly degraded

during the S phase. Found in a ternary complex with ERI1 and the stem-loop structure of the 3' end of histone mRNA.

Associates with polyribosomes. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP,

SNRPB, SYNCRIP and YBX1 (By similarity). Binds in a cooperative manner with ERI1 to the mature 3'-end of histone mRNAs

(By similarity)

Subcellular location: Cytoplasm. Nucleus. Note=Polyribosome-associated. Localizes predominantly in the nucleus at the

G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to

histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in

the nucleus by the Importin alpha/Importin beta receptor

Developmental stage: Regulated during the cell cycle: protein levels increase 10 to 20 fold in the late G1 and decrease

at the S/G2 border

2 PDB 3D structures from and Proteopedia for SLBP:

2KJM (3D)

4HXH (3D)

Secondary accessions: B3KRJ5

Alternative splicing: 2 isoforms: Q14493-1 Q14493-2

Explore the universe of human proteins at neXtProt for SLBP: NX_Q14493

Post-translational modifications:

Phosphorylated on Thr-61 and Thr-62 in the S-phase. Phosphorylation of Thr-62 by CDK1 primes phosphorylation of Thr-61

by CK2. Phosphorylation of Thr-62 is required for its degradation by the proteasome at the end of the S phase. Its

degradation is not required for histone mRNA degradation at the end of the S phase. All the phosphorylated forms

detected are present in the cytoplasm. Both unphosphorylated and phosphorylated forms bind the stem-loop structure of

histone mRNAs¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14493

SLBP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006518.1

ENSEMBL proteins:

ENSP00000406322 ENSP00000417686 ENSP00000418869 ENSP00000316490 ENSP00000426891

ENSP00000418658 ENSP00000417359

Reactome Protein details: Q14493
Human Recombinant Protein Products for SLBP:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLBP OriGene Custom Protein Services for SLBP
	GenScript Custom Purified and Recombinant Proteins Services for SLBP
	Novus Biologicals SLBP Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLBP

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	15829567
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IDA	15829567
GO:0005829	cytosol	TAS	--
GO:0030529	ribonucleoprotein complex	TAS	10825184

SLBP for ontologies About GeneDecksing

SLBP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SLBP
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLBP
	GenScript Custom Superior Antibodies Services for SLBP
	Novus Biologicals SLBP Antibodies
	Abcam antibodies for SLBP
	Uscn Antibodies for SLBP
	ThermoFisher Antibodies for SLBP

Assay Products for SLBP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLBP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLBP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLBP for domains About GeneDecksing

1 InterPro domain/family:

IPR026502 SLBP1/SLBP2

Graphical View of Domain Structure for InterPro Entry Q14493

ProtoNet protein and cluster: Q14493

UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493

Domain: Amino acids 31-34, 96-99 and 241-244 are necessary for interaction with the Importin alpha/Importin beta

receptor. The first 18 amino acids, amino acids 69-76 and 179-182 are necessary for interaction with TNPO3. Amino

acids 31-34, 96-99 and 241-244 are necessary for nuclear localization

Similarity: Belongs to the SLBP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SLBP_HUMAN, Q14493

Function: RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of

replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex

between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE).

Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation

machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression.

Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds

to the 5' side of the stem-loop structure of histone pre-mRNAs

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003729	mRNA binding	IDA	16912046
GO:0005515	protein binding	IPI	15829567
GO:0071207	histone pre-mRNA stem-loop binding	ISS	--
GO:0071208	histone pre-mRNA DCP binding	ISS	--

SLBP for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for SLBP:

Increased S DNA content

Increased cell number in S

S arrest

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLBP

miRNA Products:		OriGene 3'-UTR Clone: SLBP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLBP
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLBP:
		hsa-miR-3942-5p hsa-miR-3120-3p hsa-miR-624* hsa-miR-507 hsa-miR-466 hsa-miR-129-5p hsa-miR-590-3p hsa-miR-450b-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SLBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLBP (see all 7) OriGene shRNA RFP: SLBP OriGene siRNA: SLBP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLBP
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLBP

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SLBP
			Sirion Biotech Customized adenovirus for overexpression of SLBP Sirion Biotech Customized adenovirus for potent knockdown of SLBP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLBP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLBP (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLBP (NM_006527)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLBP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLBP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLBP
		Search LifeMap BioReagents cell lines for SLBP
		Sirion Biotech Customized stable knockdown cell line services for SLBP Sirion Biotech Customized inducible knockdown cell line services for SLBP Sirion Biotech Customized stable overexpressing cell line services for SLBP Sirion Biotech Customized inducible overexpressing cell line services for SLBP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLBP

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

RNA Polymerase II Transcription Termination

	RNA Polymerase II Transcription Termination	1.00			Cleavage of Growing Transcript in the Termination Region	1.00
	Post-Elongation Processing of the Transcript	1.00

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

Post-Elongation Processing of Intronless pre-mRNA

Processing of Capped Intronless Pre-mRNA

1.00

Post-Elongation Processing of Intronless pre-mRNA

1.00

mRNA Splicing - Major Pathway

Processing of Capped Intron-Containing Pre-mRNA

0.96

mRNA Processing

0.82

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for SLBP

Cell Cycle / Checkpoint Control

5/14 Reactome Pathways for SLBP (see all 14)

	Transport of Mature Transcript to Cytoplasm
	RNA Polymerase II Transcription
	Transcription
	Cleavage of Growing Transcript in the Termination Region
	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

SLBP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SLBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for SLBP (Q14493³ ENSP00000417686⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LSM10	Q969L4³, ENSP00000319341⁴	I2D: score=2 STRING: ENSP00000319341
UPF1	Q92900³, ENSP00000262803⁴	I2D: score=1 STRING: ENSP00000262803
ERI1	Q8IV48³, ENSP00000250263⁴	I2D: score=1 STRING: ENSP00000250263
ZNF473	Q8WTR7³, ENSP00000270617⁴	I2D: score=4 STRING: ENSP00000270617
USP8	P40818³, ENSP00000302239⁴	I2D: score=2 STRING: ENSP00000302239

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006369	termination of RNA polymerase II transcription	TAS	--
GO:0006397	mRNA processing	TAS	--
GO:0006398	histone mRNA 3'-end processing	ISS	--
GO:0006406	mRNA export from nucleus	TAS	--

SLBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLBP
Search CenterWatch for drugs/clinical trials and news about SLBP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLBP gene:

NM_006527.2

Unigene Cluster for SLBP:

Stem-loop binding protein

Hs.298345 [show with all ESTs]

Unigene Representative Sequence: AK094257

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000429429(uc003gdk.1) ENST00000489418(uc003gdi.1 uc011bvf.1 uc003gdl.1)

ENST00000460392 ENST00000318386 ENST00000483348 ENST00000488267 ENST00000480936

miRNA Products:		OriGene 3'-UTR Clone: SLBP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLBP
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLBP:
		hsa-miR-3942-5p hsa-miR-3120-3p hsa-miR-624* hsa-miR-507 hsa-miR-466 hsa-miR-129-5p hsa-miR-590-3p hsa-miR-450b-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SLBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLBP (see all 7) OriGene shRNA RFP: SLBP OriGene siRNA: SLBP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLBP
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLBP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLBP (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLBP (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLBP (NM_006527)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLBP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLBP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLBP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLBP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLBP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLBP

Additional cDNA sequence:

AK091735.1 AK093314.1 AK094257.1 AK300826.1 AK315635.1 BC014908.1 BC015703.1 BT007433.1

U75679.1 Z71188.1

13 DOTS entries:

DT.442797 DT.100817799 DT.97846195 DT.100817803 DT.100817798 DT.100036572 DT.100817805 DT.100817806

DT.102832421 DT.102832423 DT.121262729 DT.95148652 DT.95254823

24/243 AceView cDNA sequences (see all 243):

CR612335 CR607040 AU156616 BC014908 CR625225 AK091735 CR612255 BU195724

AI924261 CR625037 BM922157 U75679 BF590552 AA744535 AU102851 CR596014

AW197179 AA583320 BQ230125 AU098556 BM977736 AI022315 CR618954 AA630018

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLBP About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b
SP1:			-		-
SP2:
SP3:					-		-		-
SP4:											-

ECgene alternative splicing isoforms for SLBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAATTGCT

About this image

SLBP expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Renal Vesicle

Kidney

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLBP

SOURCE GeneReport for Unigene cluster: Hs.298345

UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for SLBP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLBP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLBP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLBP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLBP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLBP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SLBP gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slbp^{1 , 5}	stem-loop binding protein^{1, 5}	85.43(n)¹ 88.89(a)¹		5 (17.83 cM)⁵ 20492¹ NM_009193.1¹ NP_033219.1¹ 33634952⁵
chicken (Gallus gallus)	Aves	SLBP¹	stem-loop binding protein	71.99(n) 72.24(a)		422902 NM_001004403.2 NP_001004403.1
lizard (Anolis carolinensis)	Reptilia	SLBP⁶	--	69(a)	1 ↔ 1	2(146512900-146513373)
African clawed frog (Xenopus laevis)	Amphibia	SLBP²	histone stem-loop binding protein	75.45(n)		U75681.1
zebrafish (Danio rerio)	Actinopterygii	Dr.26399²	Danio rerio cDNA clone IMAGE5412740, partial cds	74.79(n)		BC055585.1
fruit fly (Drosophila melanogaster)	Insecta	Slbp⁶	Stem-loop binding protein	22(a)	1 ↔ 1	3R(24977793-24978969)
worm (Caenorhabditis elegans)	Secernentea	cdl-1⁶	Histone RNA hairpin-binding protein	13(a)	1 ↔ 1	II(10785391-10787206)

ENSEMBL Gene Tree for SLBP (if available)
TreeFam Gene Tree for SLBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLBP gene

SLBP for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for SLBP
PGOHUM00000236905 PGOHUM00000240424 PGOHUM00000235769

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184165715^1,2		--	1694085(+)	`AAGGCC/TCCCGG`	1	--	ds500¹		0	--	--	--	--
rs798718^1,2	C,F,A	--	1694185(+)	`GACCAA/GCATGG`	1	--	ds500¹		8		NA WA CSA	18
rs150216761^1,2		--	1694186(+)	`ACCAGC/TATGGA`	1	--	ds500¹		0	--	--	--	--
rs145733127^1,2		--	1694295(+)	`AACCCA/GGGAGA`	1	--	ds500¹		0	--	--	--	--
rs188569415^1,2		--	1694323(+)	`CATGAC/TTGCAC`	1	--	ds500¹		0	--	--	--	--
rs76577154^1,2	C,F	--	1694487(+)	`TCTCAC/TGGCAG`	1	--	ds500¹		1		WA	118
rs112061197^1,2	C	--	1694526(+)	`GTGAAT/AGAGGG`	1	--	ds500¹		1		CSA	1
rs115326684^1,2	C,F	--	1694626(+)	`AGAAAA/GTCTGT`	1	--	ut3¹		1		WA	118
rs180728523^1,2		--	1694693(+)	`TTCTTC/TCTAAA`	1	--	ut3¹		0	--	--	--	--
rs75528032^1,2	C,F	--	1694700(+)	`TAAATC/TGCTCC`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for SLBP (1694527 - 1714282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLBP
2 CNVs: 30192 3476
Human Gene Mutation Database (HGMD): SLBP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLBP

DNA2.0 Custom Variant and Variant Library Synthesis for SLBP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLBP for disorders           About GeneDecksing

OMIM gene information: 602422    OMIM disorders: --

6 diseases for SLBP:    About MalaCards

wolf-hirschhorn syndrome urinary bladder cancer digeorge syndrome dermatomyositis

sarcoma carcinoma

1 Novoseek disease relationship for SLBP gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
accca	90.8	3	15451662 (1), 14536070 (1)

Export disorders for SLBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLBP gene, integrated from 9 sources (see all 97):
(articles sorted by number of sources associating them with SLBP)

Utopia: connect your pdf to the dynamic
world of online information

The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein. (PubMed id 9049306)^{1, 2, 3, 9} Martin F.... Mueller B. (1997)
Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3. (PubMed id 1338771)^{1, 2, 3} McCombie W.R....Venter J.C. (1992)
Nuclear import of the stem-loop binding protein and localization during the cell cycle. (PubMed id 15829567)^{1, 2, 9} Erkmann J.A.... Marzluff W.F. (2005)
Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase. (PubMed id 12588979)^{1, 2, 9} Zheng L....Marzluff W.F. (2003)
Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase. (PubMed id 18490441)^{1, 2, 9} Koseoglu M.M.... Marzluff W.F. (2008)
Knockdown of SLBP results in nuclear retention of histone mRNA. (PubMed id 19155325)^{1, 2, 9} Sullivan K.D....Wagner E.J. (2009)
SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PubMed id 18025107)^{1, 2, 9} Cakmakci N.G....Marzluff W.F. (2008)
The protein that binds the 3' end of histone mRNA: a novel RNA- binding protein required for histone pre-mRNA processing. (PubMed id 8957003)^{1, 2, 9} Wang Z.-F....Marzluff W.F. (1996)
Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)^{1, 2, 9} Mullen T.E. and Marzluff W.F. (2008)
Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. (PubMed id 16912046)^{1, 2} Yang X.-C.... Dominski Z. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7884	HGNC: 10904	AceView: SLBP	Ensembl:ENSG00000163950	euGenes: HUgn7884
ECgene: SLBP	H-InvDB: SLBP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLBP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLBP gene:
Search GeneIP for patents involving SLBP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SLBP
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLBP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLBP
	OriGene Protein Over-expression Lysate for SLBP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLBP		OriGene 3'-UTR Clone for SLBP
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLBP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLBP
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLBP		OriGene Custom Protein Services for SLBP
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLBP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLBP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLBP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLBP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLBP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLBP

	GenScript Custom Purified and Recombinant Proteins Services for SLBP		GenScript cDNA clones with any tag delivered in your preferred vector for SLBP
	GenScript Custom Assay Services for SLBP		GenScript Custom Superior Antibodies Services for SLBP
	GenScript Custom overexpressing Cell Line Services for SLBP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for SLBP

	Regulatory tfbs in SLBP promoter
	Search Chromatin IP Primers for SLBP
	RT² qPCR Primer Assay in human, mouse, rat SLBP
	GNC Network for SLBP
	SABiosciences Custom PCR Arrays for SLBP

Search Tocris compounds for SLBP

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLBP antibodies
	SLBP proteins

	Antibodies for SLBP
	See all of Abcam's Antibodies, Kits and Proteins for SLBP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLBP Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLBP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLBP

	SwitchGear 3'UTR luciferase reporter plasmids for SLBP
	SwitchGear Promoter luciferase reporter plasmids for SLBP

ThermoFisher Antibodies for SLBP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLBP

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLBP

Sirion Biotech Customized:

	stable knockdown cell line services for SLBP
	inducible knockdown cell line services for SLBP
	design and validation of potent shRNA sequences against SLBP
	adenovirus for potent knockdown of SLBP
	adenovirus for overexpression of SLBP
	stable overexpressing cell line services for SLBP
	inducible overexpressing cell line services for SLBP

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLBP gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SLBP Gene

stem-loop binding protein

Aliases
for SLBP gene

Summaries
for SLBP gene

Genomic Views
for SLBP gene

Proteins
for SLBP gene

Protein Domains /
Families
for SLBP gene

Function
for SLBP gene

Pathways & Interactions
for SLBP gene

Drugs & Compounds
for SLBP gene

Transcripts
for SLBP gene

Expression
for SLBP gene

Orthologs
for SLBP gene

Paralogs
for SLBP gene

Genomic Variants
for SLBP gene

Disorders / Diseases
for SLBP gene

Publications
for SLBP gene

External Searches for SLBP gene

Genome Databases showing SLBP gene

Other Databases showing SLBP gene

Specialized Databases showing SLBP gene

Intellectual Property
for SLBP gene

Products
for SLBP gene

View Random Gene

Advanced Search

Export list of displayed genes

SLBP Gene

stem-loop binding protein

Aliasesfor SLBP gene

Summariesfor SLBP gene

Genomic Viewsfor SLBP gene

Proteinsfor SLBP gene

Protein Domains /Familiesfor SLBP gene

Functionfor SLBP gene

Pathways & Interactionsfor SLBP gene

Drugs & Compoundsfor SLBP gene

Transcriptsfor SLBP gene

Expression for SLBP gene

Orthologsfor SLBP gene

Paralogsfor SLBP gene

Genomic Variantsfor SLBP gene

Disorders / Diseasesfor SLBP gene

Publicationsfor SLBP gene

External Searches for SLBP gene

Genome Databases showing SLBP gene

Other Databases showing SLBP gene

Specialized Databases showing SLBP gene

Intellectual Propertyfor SLBP gene

Productsfor SLBP gene

View Random Gene

Aliases
for SLBP gene

Summaries
for SLBP gene

Genomic Views
for SLBP gene

Proteins
for SLBP gene

Protein Domains /
Families
for SLBP gene

Function
for SLBP gene

Pathways & Interactions
for SLBP gene

Drugs & Compounds
for SLBP gene

Transcripts
for SLBP gene

Expression
for SLBP gene

Orthologs
for SLBP gene

Paralogs
for SLBP gene

Genomic Variants
for SLBP gene

Disorders / Diseases
for SLBP gene

Publications
for SLBP gene

Intellectual Property
for SLBP gene

Products
for SLBP gene