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SLBP Gene

protein-coding   GIFtS: 55
GCID: GC04M001694

Stem-Loop Binding Protein

(Previous name: stem-loop (histone) binding protein)
  See SLBP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Stem-Loop Binding Protein1 2     Histone Stem-Loop-Binding Protein2 3
HBP2 3 5     Hairpin Binding Protein, Histone2
Stem-Loop (Histone) Binding Protein1 2     Histone RNA Hairpin-Binding Protein2
Histone Binding Protein1 2     Histone Stem-Loop Binding Protein2

External Ids:    HGNC: 109041   Entrez Gene: 78842   Ensembl: ENSG000001639507   OMIM: 6024225   UniProtKB: Q144933   

Export aliases for SLBP gene to outside databases

Previous GC identifers: GC04M001686 GC04M001656 GC04M001661 GC04M001664 GC04M001637


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLBP Gene:
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone
mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The
stem-loop structure is essential for efficient processing but this structure also controls the transport,
translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle,
increasing more than 10-fold during the latter part of G1. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLBP Gene:
SLBP (stem-loop binding protein) is a protein-coding gene. Diseases associated with SLBP include wolf-hirschhorn syndrome. GO annotations related to this gene include mRNA binding and histone pre-mRNA stem-loop binding.

UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493
Function: RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of
replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex
between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element
(HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the
translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone
gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support
early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs

Gene Wiki entry for SLBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLBP gene promoter:
         AML1a   p53   HTF   Nkx2-5   NF-E2 p45   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLBP promoter sequence
   Search Chromatin IP Primers for SLBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

SLBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLBP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M001694:  view genomic region     (about GC identifiers)

Start:
1,694,527 bp from pter      End:
1,714,282 bp from pter
Size:
19,756 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493 (See protein sequence)
Recommended Name: Histone RNA hairpin-binding protein  
Size: 270 amino acids; 31286 Da
Subunit: Monomer. SLBP/pre-mRNA complex interacts with ZNF473. Interacts with the Importin alpha/Importin beta
receptor, LSM1, MIF4GD, TNPO3 and UPF1. Interaction with LSM1 occurs when histone mRNA is being rapidly degraded
during the S phase. Found in a ternary complex with ERI1 and the stem-loop structure of the 3' end of histone
mRNA. Associates with polyribosomes. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11,
SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Binds in a cooperative manner with ERI1 to the mature 3'-end of
histone mRNAs (By similarity)
Developmental stage: Regulated during the cell cycle: protein levels increase 10 to 20 fold in the late G1 and
decrease at the S/G2 border
2 PDB 3D structures from and Proteopedia for SLBP:
2KJM (3D)        4L8R (3D)    
Secondary accessions: B3KRJ5
Alternative splicing: 2 isoforms:  Q14493-1   Q14493-2   

Explore the universe of human proteins at neXtProt for SLBP: NX_Q14493

Explore proteomics data for SLBP at MOPED

Post-translational modifications: 

  • Phosphorylated on Thr-61 and Thr-62 in the S-phase. Phosphorylation of Thr-62 by CDK1 primes phosphorylation of
    Thr-61 by CK2. Phosphorylation of Thr-62 is required for its degradation by the proteasome at the end of the S
    phase. Its degradation is not required for histone mRNA degradation at the end of the S phase. All the
    phosphorylated forms detected are present in the cytoplasm. Both unphosphorylated and phosphorylated forms bind
    the stem-loop structure of histone mRNAs. Phosphorylation at Thr-171 increases affinity for histone mRNAs1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006518.1  
    ENSEMBL proteins: 
     ENSP00000406322   ENSP00000417686   ENSP00000316490   ENSP00000426891   ENSP00000418658  
     ENSP00000417359  
    Reactome Protein details: Q14493

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026502 SLBP1/SLBP2

    Graphical View of Domain Structure for InterPro Entry Q14493

    ProtoNet protein and cluster: Q14493

    UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493
    Domain: Amino acids 31-34, 96-99 and 241-244 are necessary for interaction with the Importin alpha/Importin beta
    receptor. The first 18 amino acids, amino acids 69-76 and 179-182 are necessary for interaction with TNPO3. Amino
    acids 31-34, 96-99 and 241-244 are necessary for nuclear localization
    Similarity: Belongs to the SLBP family


    Find genes that share domains with SLBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLBP_HUMAN, Q14493
    Function: RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of
    replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex
    between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element
    (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the
    translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone
    gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support
    early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA16912046
    GO:0005515protein binding IPI15829567
    GO:0044822poly(A) RNA binding IDA--
    GO:0071207histone pre-mRNA stem-loop binding ISS--
    GO:0071208histone pre-mRNA DCP binding ISS--
         
    Find genes that share ontologies with SLBP           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SLBP:
     Increased S DNA content  Increased cell number in S  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLBP
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    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate SLBP:
    hsa-miR-3942-5p hsa-miR-3120-3p hsa-miR-624* hsa-miR-507 hsa-miR-466 hsa-miR-129-5p hsa-miR-590-3p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLBP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLBP_HUMAN, Q14493: Cytoplasm. Nucleus. Note=Polyribosome-associated. Localizes predominantly in the nucleus at
    the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm.
    Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the
    cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15829567
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA15829567
    GO:0005829cytosol TAS--
    GO:0030529ribonucleoprotein complex TAS10825184

    Find genes that share ontologies with SLBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLBP About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    Processing of Capped Intronless Pre-mRNA0.52
    Cleavage of Growing Transcript in the Termination Region0.80
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs0.00
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    4mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.78
    5Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60


    Find genes that share SuperPaths with SLBP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SLBP
        Cell Cycle / Checkpoint Control


    3 Reactome Pathways for SLBP
        Transport of the SLBP Dependant Mature mRNA
    Cleavage of Growing Transcript in the Termination Region
    SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLBP
    Interactions:

        GeneGlobe Interaction Network for SLBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLBP (Q144933 ENSP000004176864) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM10Q969L43, ENSP000003193414I2D: score=2 STRING: ENSP00000319341
    UPF1Q929003, ENSP000002628034I2D: score=1 STRING: ENSP00000262803
    ERI1Q8IV483, ENSP000002502634I2D: score=1 STRING: ENSP00000250263
    ZNF473Q8WTR73, ENSP000002706174I2D: score=4 STRING: ENSP00000270617
    USP8P408183, ENSP000003022394I2D: score=2 STRING: ENSP00000302239
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006398histone mRNA 3'-end processing ISS--
    GO:0006406mRNA export from nucleus TAS--
    GO:0008334histone mRNA metabolic process TAS--

    Find genes that share ontologies with SLBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SLBP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLBP gene: 
    NM_006527.2  

    Unigene Cluster for SLBP:

    Stem-loop binding protein
    Hs.298345  [show with all ESTs]
    Unigene Representative Sequence: AK094257
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429429(uc003gdk.1) ENST00000489418(uc003gdi.1 uc011bvf.1 uc003gdl.1)
    ENST00000318386 ENST00000483348 ENST00000488267 ENST00000480936
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate SLBP:
    hsa-miR-3942-5p hsa-miR-3120-3p hsa-miR-624* hsa-miR-507 hsa-miR-466 hsa-miR-129-5p hsa-miR-590-3p hsa-miR-450b-5p
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    Additional mRNA sequence: 

    AK091735.1 AK093314.1 AK094257.1 AK300826.1 AK315635.1 BC014908.1 BC015703.1 BT007433.1 
    U75679.1 Z71188.1 

    13 DOTS entries:

    DT.442797  DT.100817799  DT.97846195  DT.100817803  DT.100817798  DT.100036572  DT.100817805  DT.100817806 
    DT.102832421  DT.102832423  DT.121262729  DT.95148652  DT.95254823 

    Selected AceView cDNA sequences (see all 243):

    AW197179 AK093314 AI278948 CR594689 BM676712 AA630018 CR593596 BE549971 
    CR612255 CB305349 AK091735 CR625037 CR600158 CR612335 AX747152 AA705380 
    AW264286 BM977736 AA744535 AA629558 BM679830 AU102851 AI022315 AU156616 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLBP    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:        -     -                                                         
    SP2:                                                                        
    SP3:              -     -     -                                             
    SP4:                                -                                       


    ECgene alternative splicing isoforms for SLBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAATTGCT
    SLBP Expression
    About this image


    SLBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    SLBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.298345

    UniProtKB/Swiss-Prot: SLBP_HUMAN, Q14493
    Tissue specificity: Widely expressed

        Custom PCR Arrays for SLBP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLBP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slbp1 , 5 stem-loop binding protein1, 5 85.43(n)1
    88.89(a)1
      5 (17.83 cM)5
    204921  NM_009193.11  NP_033219.11 
     336349525 
    chicken
    (Gallus gallus)
    Aves SLBP1 stem-loop binding protein 71.86(n)
    72.62(a)
      422902  NM_001004403.2  NP_001004403.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLBP6
    stem-loop binding protein
    69(a)
    1 ↔ 1
    2(146512900-146513373)
    African clawed frog
    (Xenopus laevis)
    Amphibia SLBP2 histone stem-loop binding protein 75.45(n)    U75681.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.263992 Danio rerio cDNA clone IMAGE5412740, partial cds 74.79(n)    BC055585.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Slbp6
    Stem-loop binding protein
    21(a)
    1 ↔ 1
    3R(24977793-24978969)
    worm
    (Caenorhabditis elegans)
    Secernentea cdl-16
    Protein CDL-1 (cdl-1) mRNA, complete cds
    17(a)
    1 ↔ 1
    II(10785452-10787265) WBGene00000411


    ENSEMBL Gene Tree for SLBP (if available)
    TreeFam Gene Tree for SLBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLBP gene

    Find genes that share paralogs with SLBP           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SLBP
    PGOHUM00000236905 PGOHUM00000240424 PGOHUM00000235769


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLBP (see all 407)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841657151,2
    --1694085(+) AAGGCC/TCCCGG 1 -- ds50010--------
    rs7987181,2
    C,F,A--1694185(+) GACCAA/GCATGG 1 -- ds50018Minor allele frequency- G:0.33NA WA CSA 18
    rs1502167611,2
    --1694186(+) ACCAGC/TATGGA 1 -- ds50010--------
    rs1457331271,2
    --1694295(+) AACCCA/GGGAGA 1 -- ds50010--------
    rs1885694151,2
    --1694323(+) CATGAC/TTGCAC 1 -- ds50010--------
    rs765771541,2
    C,F--1694487(+) TCTCAC/G/TGGCAG 1 -- ds50011WA 118
    rs1120611971,2
    C--1694526(+) GTGAAT/AGAGGG 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1153266841,2
    C,F--1694626(+) AGAAAA/GTCTGT 1 -- ut311Minor allele frequency- G:0.04WA 118
    rs1807285231,2
    --1694693(+) TTCTTC/TCTAAA 1 -- ut310--------
    rs755280321,2
    C,F--1694700(+) TAAATC/TGCTCC 1 -- ut311Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for SLBP (1694527 - 1714282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLBP (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508989CNV Insertion20534489
    dgv5416n71CNV Loss21882294
    nsv878347CNV Loss21882294
    nsv470000CNV Loss18288195
    nsv878368CNV Loss21882294
    nsv878393CNV Loss21882294
    dgv5415n71CNV Loss21882294
    nsv822437CNV Loss20364138
    dgv5412n71CNV Loss21882294
    nsv878328CNV Loss21882294

    Human Gene Mutation Database (HGMD): SLBP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLBP
    DNA2.0 Custom Variant and Variant Library Synthesis for SLBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602422    OMIM disorders: --

    1 disease for SLBP:    
    About MalaCards
    wolf-hirschhorn syndrome


    Find genes that share disorders with SLBP           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLBP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    accca 90.8 3 15451662 (1), 14536070 (1)


    Export disorders for SLBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLBP gene, integrated from 10 sources (see all 101):
    (articles sorted by number of sources associating them with SLBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein. (PubMed id 9049306)1, 2, 3, 9 Martin F.... Mueller B. (EMBO J. 1997)
    2. Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3. (PubMed id 1338771)1, 2, 3 McCombie W.R....Venter J.C. (Nat. Genet. 1992)
    3. Nuclear import of the stem-loop binding protein and localization during the cell cycle. (PubMed id 15829567)1, 2, 9 Erkmann J.A.... Marzluff W.F. (Mol. Biol. Cell 2005)
    4. Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase. (PubMed id 12588979)1, 2, 9 Zheng L....Marzluff W.F. (Mol. Cell. Biol. 2003)
    5. Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase. (PubMed id 18490441)1, 2, 9 Koseoglu M.M.... Marzluff W.F. (Mol. Cell. Biol. 2008)
    6. Knockdown of SLBP results in nuclear retention of histone mRNA. (PubMed id 19155325)1, 2, 9 Sullivan K.D.... Wagner E.J. (RNA 2009)
    7. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. (PubMed id 18025107)1, 2, 9 Cakmakci N.G.... Marzluff W.F. (Mol. Cell. Biol. 2008)
    8. The protein that binds the 3' end of histone mRNA: a novel RNA- binding protein required for histone pre-mRNA processing. (PubMed id 8957003)1, 2, 9 Wang Z.-F....Marzluff W.F. (Genes Dev. 1996)
    9. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2, 9 Mullen T.E. and Marzluff W.F. (Genes Dev. 2008)
    10. Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization. (PubMed id 22439849)1, 2 Zhang M.... Thapar R. (Biochemistry 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7884 HGNC: 10904 AceView: SLBP Ensembl:ENSG00000163950 euGenes: HUgn7884
    ECgene: SLBP H-InvDB: SLBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLBP gene:
    Search GeneIP for patents involving SLBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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