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Aliases for SLAMF9 Gene

Aliases for SLAMF9 Gene

  • SLAM Family Member 9 2 3 5
  • CD2 Family Member 10 3 4
  • CD84 Homolog 1 3 4
  • CD2F-10 3 4
  • CD84-H1 3 4
  • CD2F10 3 4
  • Signaling Lymphocytic Activation Molecule Family Member 2001 3
  • Signaling Lymphocytic Activation Molecule Family Member 9 3
  • Cluster Of Differentiation 2 Antigen Family Member 10 3
  • Cluster Of Differentiation 84 Homolog 1 3
  • CD84H1 3
  • SF2001 3

External Ids for SLAMF9 Gene

Previous GeneCards Identifiers for SLAMF9 Gene

  • GC01M157138
  • GC01M156734
  • GC01M158187
  • GC01M159923
  • GC01M131277

Summaries for SLAMF9 Gene

Entrez Gene Summary for SLAMF9 Gene

  • This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

GeneCards Summary for SLAMF9 Gene

SLAMF9 (SLAM Family Member 9) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is CD84.

UniProtKB/Swiss-Prot for SLAMF9 Gene

  • May play a role in the immune response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF9 Gene

Genomics for SLAMF9 Gene

Regulatory Elements for SLAMF9 Gene

Enhancers for SLAMF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F159888 1.6 FANTOM5 Ensembl ENCODE 5.8 +63.9 63854 3.2 HDGF TBP ATF1 KLF17 PTRF SIN3A ZNF2 RAD21 RFX5 GLIS2 ENSG00000272668 VSIG8 SLAMF8 C1orf204 FCRL6 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01F159879 1.6 FANTOM5 Ensembl ENCODE 5.4 +73.2 73154 4.2 PKNOX1 SIN3A FOS DEK ZNF518A MAFF SMARCA4 GLIS1 STAT3 KDM1A ENSG00000228606 ENSG00000272668 SLAMF8 VSIG8 SLAMF9 C1orf204 TAGLN2 COPA ENSG00000256029 MIR4259
GH01F160427 1.7 FANTOM5 Ensembl ENCODE 3.3 -476.4 -476387 6.0 HDGF PKNOX1 SIN3A ZNF766 CBX5 ZNF143 SP3 JUNB REST TBX21 VANGL2 SLAMF7 SLAMF1 NCSTN ENSG00000228863 NHLH1 ITLN1 CD48 CD244 LY9
GH01F159848 1.2 FANTOM5 Ensembl ENCODE 4.4 +104.7 104659 2.0 ZNF589 HLF CEBPB FOS ZNF24 ENSG00000272668 SLAMF9 SLAMF8 TAGLN2 ENSG00000212161 GC01M159841 GC01M159852
GH01F159828 1.4 FANTOM5 Ensembl ENCODE 3.7 +124.2 124228 2.7 CTCF ARNT ZNF2 ZNF644 RAD21 ZNF143 SMC3 FOS ZNF600 MAZ C1orf204 SLAMF8 SLAMF9 GC01M159841
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLAMF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLAMF9 Gene

159,951,492 bp from pter
159,954,254 bp from pter
2,763 bases
Minus strand

Genomic View for SLAMF9 Gene

Genes around SLAMF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF9 Gene

Proteins for SLAMF9 Gene

  • Protein details for SLAMF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAM family member 9
    Protein Accession:
    Secondary Accessions:
    • Q5JRQ9
    • Q5JRR0
    • Q6UWG1

    Protein attributes for SLAMF9 Gene

    289 amino acids
    Molecular mass:
    32436 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLAMF9 Gene


neXtProt entry for SLAMF9 Gene

Post-translational modifications for SLAMF9 Gene

  • Glycosylation at Asn 99 and Asn 208

Other Protein References for SLAMF9 Gene

No data available for DME Specific Peptides for SLAMF9 Gene

Domains & Families for SLAMF9 Gene

Gene Families for SLAMF9 Gene

Protein Domains for SLAMF9 Gene

Suggested Antigen Peptide Sequences for SLAMF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SLAMF9: view

Function for SLAMF9 Gene

Molecular function for SLAMF9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response.
genes like me logo Genes that share phenotypes with SLAMF9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLAMF9

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLAMF9 Gene

Localization for SLAMF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAMF9 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLAMF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF9: view

Pathways & Interactions for SLAMF9 Gene

SuperPathways for SLAMF9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLAMF9 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLAMF9 Gene

Transcripts for SLAMF9 Gene

Unigene Clusters for SLAMF9 Gene

SLAM family member 9:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP2: -
SP3: - -

Relevant External Links for SLAMF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAMF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLAMF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF9 Gene

This gene is overexpressed in Liver (x9.8), Whole Blood (x6.5), and Testis (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of SLAMF9 Gene:


SOURCE GeneReport for Unigene cluster for SLAMF9 Gene:


mRNA Expression by UniProt/SwissProt for SLAMF9 Gene:

Tissue specificity: Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP-1.
genes like me logo Genes that share expression patterns with SLAMF9: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLAMF9 Gene

Orthologs for SLAMF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLAMF9 34 35
  • 97.46 (n)
(Bos Taurus)
Mammalia SLAMF9 34 35
  • 81.14 (n)
(Rattus norvegicus)
Mammalia Slamf9 34
  • 75.13 (n)
(Canis familiaris)
Mammalia SLAMF9 34 35
  • 74.87 (n)
(Mus musculus)
Mammalia Slamf9 34 16 35
  • 74.74 (n)
(Monodelphis domestica)
Mammalia SLAMF9 35
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
Species where no ortholog for SLAMF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF9 Gene

Gene Tree for SLAMF9 (if available)
Gene Tree for SLAMF9 (if available)

Paralogs for SLAMF9 Gene

Paralogs for SLAMF9 Gene

(3) SIMAP similar genes for SLAMF9 Gene using alignment to 2 proteins: Pseudogenes for SLAMF9 Gene

genes like me logo Genes that share paralogs with SLAMF9: view

Variants for SLAMF9 Gene

Sequence variations from dbSNP and Humsavar for SLAMF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10532824 -- 159,976,113(+) TGTGT(-/GTGTGTGTGT)AAGTT intron-variant
rs10908752 -- 159,985,204(+) TTAAT(A/C)CCTAC upstream-variant-2KB
rs111272082 -- 159,970,844(+) ATACA(A/G)TGAAA intron-variant
rs111338035 -- 159,975,975(+) TTCAG(A/G)ATCTG intron-variant
rs111417012 -- 159,977,536(+) GGCCA(-/G)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF9 Gene

Variant ID Type Subtype PubMed ID
esv3578219 CNV loss 25503493
esv3587705 CNV loss 21293372
nsv520773 CNV loss 19592680
nsv524006 CNV gain 19592680
nsv548055 CNV loss 21841781

Variation tolerance for SLAMF9 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLAMF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF9 Gene

Disorders for SLAMF9 Gene

Relevant External Links for SLAMF9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLAMF9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAMF9 Gene

Publications for SLAMF9 Gene

  1. CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily. (PMID: 11685473) Fennelly J.A. … Evans E.J. (Immunogenetics 2001) 2 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue. (PMID: 11300479) Zhang W. … Cao X. (Clin. Cancer Res. Suppl. 2001) 3 4 64

Products for SLAMF9 Gene

Sources for SLAMF9 Gene

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