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Aliases for SLAMF9 Gene

Aliases for SLAMF9 Gene

  • SLAM Family Member 9 2 3
  • CD2 Family Member 10 3 4
  • CD84 Homolog 1 3 4
  • CD2F-10 3 4
  • CD84-H1 3 4
  • CD2F10 3 4
  • Signaling Lymphocytic Activation Molecule Family Member 2001 3
  • Signaling Lymphocytic Activation Molecule Family Member 9 3
  • Cluster Of Differentiation 2 Antigen Family Member 10 3
  • Cluster Of Differentiation 84 Homolog 1 3
  • CD84H1 3
  • SF2001 3

External Ids for SLAMF9 Gene

Summaries for SLAMF9 Gene

Entrez Gene Summary for SLAMF9 Gene

  • This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

GeneCards Summary for SLAMF9 Gene

SLAMF9 (SLAM Family Member 9) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.

UniProtKB/Swiss-Prot for SLAMF9 Gene

  • May play a role in the immune response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF9 Gene

Genomics for SLAMF9 Gene

Genomic Location for SLAMF9 Gene

Start:
159,951,492 bp from pter
End:
159,954,254 bp from pter
Size:
2,763 bases
Orientation:
Minus strand

Genomic View for SLAMF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLAMF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF9 Gene

Regulatory Elements for SLAMF9 Gene

Proteins for SLAMF9 Gene

  • Protein details for SLAMF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A28-SLAF9_HUMAN
    Recommended name:
    SLAM family member 9
    Protein Accession:
    Q96A28
    Secondary Accessions:
    • Q5JRQ9
    • Q5JRR0
    • Q6UWG1

    Protein attributes for SLAMF9 Gene

    Size:
    289 amino acids
    Molecular mass:
    32436 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLAMF9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF9 Gene

Proteomics data for SLAMF9 Gene at MOPED

Post-translational modifications for SLAMF9 Gene

  • Glycosylation at Asn99 and Asn208

Other Protein References for SLAMF9 Gene

No data available for DME Specific Peptides for SLAMF9 Gene

Domains for SLAMF9 Gene

Gene Families for SLAMF9 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SLAMF9 Gene

UniProtKB/Swiss-Prot:

SLAF9_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q96A28
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q96A28
genes like me logo Genes that share domains with SLAMF9: view

Function for SLAMF9 Gene

Molecular function for SLAMF9 Gene

UniProtKB/Swiss-Prot Function: May play a role in the immune response.

Gene Ontology (GO) - Molecular Function for SLAMF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLAMF9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLAMF9 Gene

Localization for SLAMF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAMF9 Gene COMPARTMENTS Subcellular localization image for SLAMF9 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLAMF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF9: view

Pathways for SLAMF9 Gene

SuperPathways for SLAMF9 Gene

No Data Available

Interacting Proteins for SLAMF9 Gene

Gene Ontology (GO) - Biological Process for SLAMF9 Gene

None

No data available for Pathways by source for SLAMF9 Gene

Transcripts for SLAMF9 Gene

Unigene Clusters for SLAMF9 Gene

SLAM family member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1:
SP2: -
SP3: - -

Relevant External Links for SLAMF9 Gene

GeneLoc Exon Structure for
SLAMF9
ECgene alternative splicing isoforms for
SLAMF9

Expression for SLAMF9 Gene

mRNA expression in normal human tissues for SLAMF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF9 Gene

This gene is overexpressed in Liver (9.8), Whole Blood (6.5), and Testis (6.5).

SOURCE GeneReport for Unigene cluster for SLAMF9 Gene Hs.661712

mRNA Expression by UniProt/SwissProt for SLAMF9 Gene

Q96A28-SLAF9_HUMAN
Tissue specificity: Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP-1.
genes like me logo Genes that share expressions with SLAMF9: view

Orthologs for SLAMF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAMF9 36
  • 97.46 (n)
  • 95.16 (a)
SLAMF9 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLAMF9 36
  • 81.14 (n)
  • 70.07 (a)
SLAMF9 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLAMF9 36
  • 74.87 (n)
  • 62.89 (a)
SLAMF9 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slamf9 36
  • 74.74 (n)
  • 60 (a)
Slamf9 16
Slamf9 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLAMF9 37
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 29 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slamf9 36
  • 75.13 (n)
  • 60.77 (a)
Species with no ortholog for SLAMF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF9 Gene

ENSEMBL:
Gene Tree for SLAMF9 (if available)
TreeFam:
Gene Tree for SLAMF9 (if available)

Paralogs for SLAMF9 Gene

Paralogs for SLAMF9 Gene

Selected SIMAP similar genes for SLAMF9 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SLAMF9 Gene

genes like me logo Genes that share paralogs with SLAMF9: view

Variants for SLAMF9 Gene

Sequence variations from dbSNP and Humsavar for SLAMF9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1317520 -- 159,952,668(+) AAGCA(A/G)ACAAA intron-variant
rs1344028 -- 159,953,685(-) CAGCT(A/G)GGTTG intron-variant
rs2249707 -- 159,953,169(-) ATACT(A/G)TGATT intron-variant
rs2789415 -- 159,954,530(-) TAGGG(A/C)AGAAT upstream-variant-2KB
rs2789416 -- 159,953,838(-) CTCCT(G/T)TTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF9 Gene

Variant ID Type Subtype PubMed ID
nsv872489 CNV Loss 21882294
nsv524006 CNV Gain 19592680
nsv520773 CNV Loss 19592680

Relevant External Links for SLAMF9 Gene

HapMap Linkage Disequilibrium report
SLAMF9

Disorders for SLAMF9 Gene

No disorders were found for SLAMF9 Gene.

No data available for UniProtKB/Swiss-Prot for SLAMF9 Gene

Publications for SLAMF9 Gene

  1. CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily. (PMID: 11685473) Fennelly J.A. … Evans E.J. (Immunogenetics 2001) 2 3 4
  2. Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue. (PMID: 11300479) Zhang W. … Cao X. (Clin. Cancer Res. Suppl. 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for SLAMF9 Gene

  • antibodies-online peptides for SLAMF9
  • antibodies-online antibodies for SLAMF9
  • antibodies-online kits for SLAMF9

Sources for SLAMF9 Gene

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