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Aliases for SLAMF8 Gene

Aliases for SLAMF8 Gene

  • SLAM Family Member 8 2 3 5
  • B-Lymphocyte Activator Macrophage Expressed 3 4
  • BCM-Like Membrane Protein 3 4
  • BLAME 3 4
  • B Lymphocyte Activator Macrophage Expressed 3
  • CD353 Antigen 4
  • SBBI42 3
  • CD353 3

External Ids for SLAMF8 Gene

Previous GeneCards Identifiers for SLAMF8 Gene

  • GC01P157013
  • GC01P156609
  • GC01P158063
  • GC01P131152

Summaries for SLAMF8 Gene

Entrez Gene Summary for SLAMF8 Gene

  • This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLAMF8 Gene

SLAMF8 (SLAM Family Member 8) is a Protein Coding gene. GO annotations related to this gene include receptor activity.

UniProtKB/Swiss-Prot for SLAMF8 Gene

  • May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Gene Wiki entry for SLAMF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF8 Gene

Genomics for SLAMF8 Gene

Regulatory Elements for SLAMF8 Gene

Enhancers for SLAMF8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLAMF8 on UCSC Golden Path with GeneCards custom track

Promoters for SLAMF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLAMF8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLAMF8 Gene

Chromosome:
1
Start:
159,826,650 bp from pter
End:
159,837,497 bp from pter
Size:
10,848 bases
Orientation:
Plus strand

Genomic View for SLAMF8 Gene

Genes around SLAMF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF8 Gene

Proteins for SLAMF8 Gene

  • Protein details for SLAMF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0V8-SLAF8_HUMAN
    Recommended name:
    SLAM family member 8
    Protein Accession:
    Q9P0V8
    Secondary Accessions:
    • Q32MC6
    • Q5VU15

    Protein attributes for SLAMF8 Gene

    Size:
    285 amino acids
    Molecular mass:
    31670 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLAMF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF8 Gene

Proteomics data for SLAMF8 Gene at MOPED

Post-translational modifications for SLAMF8 Gene

Other Protein References for SLAMF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLAMF8 Gene

Domains & Families for SLAMF8 Gene

Protein Domains for SLAMF8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLAMF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0V8

UniProtKB/Swiss-Prot:

SLAF8_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SLAMF8: view

Function for SLAMF8 Gene

Molecular function for SLAMF8 Gene

UniProtKB/Swiss-Prot Function:
May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
genes like me logo Genes that share phenotypes with SLAMF8: view

Animal Models for SLAMF8 Gene

MGI Knock Outs for SLAMF8:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLAMF8

CRISPR Products

miRNA for SLAMF8 Gene

miRTarBase miRNAs that target SLAMF8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLAMF8 Gene

Localization for SLAMF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAMF8 Gene COMPARTMENTS Subcellular localization image for SLAMF8 gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SLAMF8 Gene

Pathways & Interactions for SLAMF8 Gene

SuperPathways for SLAMF8 Gene

No Data Available

Interacting Proteins for SLAMF8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000289707%0d%0a9606.ENSP00000357025%0d%0a
Selected Interacting proteins: ENSP00000289707 for SLAMF8 Gene via STRING

Symbol External ID(s) Details
CD48

Gene Ontology (GO) - Biological Process for SLAMF8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLAMF8 Gene

Drugs & Compounds for SLAMF8 Gene

No Compound Related Data Available

Transcripts for SLAMF8 Gene

Unigene Clusters for SLAMF8 Gene

SLAM family member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: - -
SP3: -

Relevant External Links for SLAMF8 Gene

GeneLoc Exon Structure for
SLAMF8
ECgene alternative splicing isoforms for
SLAMF8

Expression for SLAMF8 Gene

mRNA expression in normal human tissues for SLAMF8 Gene

mRNA differential expression in normal tissues according to GTEx for SLAMF8 Gene

This gene is overexpressed in Spleen (x5.4) and Lung (x4.9).

Protein differential expression in normal tissues from HIPED for SLAMF8 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLAMF8 Gene



SOURCE GeneReport for Unigene cluster for SLAMF8 Gene Hs.438683

mRNA Expression by UniProt/SwissProt for SLAMF8 Gene

Q9P0V8-SLAF8_HUMAN
Tissue specificity: Expressed in lymph node, spleen, thymus and bone marrow.
genes like me logo Genes that share expression patterns with SLAMF8: view

Protein tissue co-expression partners for SLAMF8 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLAMF8 Gene

Orthologs for SLAMF8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLAMF8 35
  • 85.24 (n)
  • 80.36 (a)
SLAMF8 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slamf8 35
  • 80.1 (n)
  • 76.98 (a)
Slamf8 16
Slamf8 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLAMF8 35
  • 99.33 (n)
  • 99.6 (a)
SLAMF8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slamf8 35
  • 80.39 (n)
  • 75.45 (a)
dog
(Canis familiaris)
Mammalia SLAMF8 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLAMF8 36
  • 64 (a)
OneToOne
Species with no ortholog for SLAMF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF8 Gene

ENSEMBL:
Gene Tree for SLAMF8 (if available)
TreeFam:
Gene Tree for SLAMF8 (if available)

Paralogs for SLAMF8 Gene

No data available for Paralogs for SLAMF8 Gene

Variants for SLAMF8 Gene

Sequence variations from dbSNP and Humsavar for SLAMF8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2494514 - 159,826,911(+) TGAGG(A/C/T)CCCTG reference, missense, utr-variant-5-prime
rs34687326 - 159,830,120(-) GTTGC(C/T)GCTGT intron-variant, reference, missense
rs3795331 - 159,832,893(+) GGCCC(A/G)TGGTA reference, missense, utr-variant-5-prime
rs2494480 -- 159,832,837(+) CCAGC(A/C)TCCCT intron-variant
rs2494495 -- 159,824,724(+) GGGCT(A/G)AGCCT upstream-variant-2KB

Variation tolerance for SLAMF8 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SLAMF8 Gene

Disorders for SLAMF8 Gene

Relevant External Links for SLAMF8

Human Genome Epidemiology (HuGE) Navigator
SLAMF8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLAMF8

No disorders were found for SLAMF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAMF8 Gene

Publications for SLAMF8 Gene

  1. Cloning, expression, and function of BLAME, a novel member of the CD2 family. (PMID: 11313408) Kingsbury G.A. … Villeval J.-L. (J. Immunol. 2001) 2 3 4 67
  2. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PMID: 12928397) Tangye S.G. … van de Weerdt B.C.M. (J. Immunol. 2003) 3 23
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for SLAMF8 Gene

Sources for SLAMF8 Gene

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