SLAMF8 Gene
protein-coding GIFtS: 44
GCID: GC01P159796
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|
SLAM family member 8
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Aliases
for SLAMF8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SLAM Family Member 81 2 | | B-Lymphocyte Activator Macrophage Expressed2 3 | | BLAME1 2 3 5 | | BCM-Like Membrane Protein2 3 | | CD3531 2 | | B Lymphocyte Activator Macrophage Expressed2 | | SBBI421 2 | | CD353 Antigen3 |
Export aliases for SLAMF8 gene to outside databasesPrevious GC identifers: GC01P157013 GC01P156609 GC01P158063 GC01P131152 |
Summaries
for SLAMF8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLAMF8:
This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteinsare characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein inmouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1containing many CD2 genes. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SLAF8_HUMAN, Q9P0V8Function: May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor
Gene Wiki entry for SLAMF8
|
Genomic Views
for SLAMF8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLAMF8 gene promoter:
Oct-B1 HOXA9 HOXA9B Spz1 oct-B3 oct-B2 Meis-1b POU2F1 POU2F1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLAMF8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAMF8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.2 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q23.1SLAMF8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P159796: view genomic region
(about GC identifiers)
Start:
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159,796,479 bp from pter |
End:
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159,807,282 bp from pter |
Size:
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10,804 bases |
Orientation:
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plus strand |
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Proteins
for SLAMF8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SLAF8_HUMAN, Q9P0V8 (See
protein sequence)Recommended Name: SLAM family member 8 precursor Size: 285 amino acids; 31670 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q32MC6 Q5VU15Alternative splicing: 2 isoforms: Q9P0V8-1 Q9P0V8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLAMF8: NX_Q9P0V8
SLAMF8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064510.1
ENSEMBL proteins: ENSP00000289707 ENSP00000357084
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLAMF8 for ontologies About GeneDecksing
SLAMF8 Antibody Products:
Assay Products for SLAMF8: |
Protein
Domains /
Families
for SLAMF8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLAMF8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0V8ProtoNet protein and cluster: Q9P0V8 UniProtKB/Swiss-Prot: SLAF8_HUMAN, Q9P0V8Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for SLAMF8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SLAF8_HUMAN, Q9P0V8Function: May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLAMF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- |
SLAMF8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SLAMF8:
Animal Models:
Mouse knock-out Slamf8tm1Lex for SLAMF8
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Slamf8):
SLAMF8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLAMF8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLAMF8
|
Drugs & Compounds
for SLAMF8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLAMF8
Search CenterWatch for drugs/clinical trials and news about SLAMF8 / SLAF8
|
Transcripts
for SLAMF8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLAMF8 gene: NM_020125.2 Unigene Cluster for SLAMF8: SLAM family member 8 Hs.438683 [show with all ESTs]Unigene Representative Sequence: NM_0201254 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000289707(uc001fue.4) ENST00000368104 ENST00000471286 ENST00000497141
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLAMF8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLAMF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLAMF8 (NM_020125) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLAMF8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF8 |
Additional cDNA sequence: AF144235.1 AF146761.1 AK074669.1 BC109194.2 11 DOTS entries: DT.441784 DT.91708048 DT.121405823 DT.97815630 DT.97837392 DT.121405954 DT.100783193 DT.100777798 DT.91708049 DT.100715115 DT.100777799 24/78 AceView cDNA sequences (see all 78): N79421 AW664177 BG230648 NM_020125 CD365198 CD368492 AA627522 BX118110 CD367956 AF146761 CA307477 AI680659 AW662401 AA320408 BM725151 CA440043 CO246344 AW206273 CA307285 N62522 AI298413 BU618114 AW952171 BF591200
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF8 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLAMF8
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Expression
for SLAMF8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLAMF8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAAACTGGC
About this image
See SLAMF8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLAMF8
SOURCE GeneReport for Unigene cluster: Hs.438683
UniProtKB/Swiss-Prot: SLAF8_HUMAN, Q9P0V8Tissue specificity: Expressed in lymph node, spleen, thymus and bone marrow
SABiosciences Custom PCR Arrays for SLAMF8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLAMF8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLAMF8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLAMF8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLAMF8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF8 |
Orthologs
for SLAMF8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SLAMF8 (if available)
TreeFam Gene Tree for SLAMF8 (if available) |
Paralogs
for SLAMF8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SLAMF8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLAMF8 (159796479 - 159807282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLAMF8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLAMF8 |
|
Disorders
/ Diseases
for SLAMF8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLAMF8 for disorders About GeneDecksing
OMIM gene information: 606620
OMIM disorders: --
3  diseases for SLAMF8: About MalaCardsdental caries hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: SLAMF8 (1 document)
Export disorders for SLAMF8 gene to outside databases
|
Publications
for SLAMF8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLAMF8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLAMF8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression, and function of BLAME, a novel member of the CD2 family. (PubMed id 11313408)1, 2, 3 Kingsbury G.A....Villeval J.-L. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PubMed id 12928397)1, 9 Tangye S.G.... van de Weerdt B.C.M. (2003)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLAMF8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLAMF8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLAMF8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLAMF8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLAMF8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLAMF8 gene:
Search GeneIP for patents involving SLAMF8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLAMF8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | SLAMF8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF8 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLAMF8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF8 |
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