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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLAMF7 Gene

protein-coding   GIFtS: 53
GCID: GC01P160709

SLAM family member 7

 Explore 13 diseases affiliated with
SLAMF7 via our new
 Human Malady Compendium 
Biological research products
for SLAMF7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
SLAM Family Member 71 2     CD2 Subset 12 3
CRACC1 2 3 5     CD2-Like Receptor-Activating Cytotoxic Cells2 3
CS11 2 3 5     19A24 Protein2
19A1 2     CD2-Like Receptor Activating Cytotoxic Cells2
CD3191 2     Novel LY9 (Lymphocyte Antigen 9) Like Protein2
Membrane Protein FOAP-122 3     CD319 Antigen3
Protein 19A2 3     Novel Ly93

External Ids:    HGNC: 213941   Entrez Gene: 578232   Ensembl: ENSG000000267517   OMIM: 6066255   UniProtKB: Q9NQ253   

Export aliases for SLAMF7 gene to outside databases

Previous GC identifers: GC01P157925 GC01P157522 GC01P158975 GC01P132065


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
Function: Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated
ERK-mediated pathway. May play a role in lymphocyte adhesion
Function: Isoform 3 does not mediate any NK cell activation

Gene Wiki entry for SLAMF7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLAMF7 gene promoter:
         TBP   STAT1   POU3F1   Pax-6   STAT1beta   LUN-1   LCR-F1   C/EBPalpha   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLAMF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLAMF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAMF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1-q24.1   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1-q24.1

SLAMF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAMF7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160709:  view genomic region     (about GC identifiers)

Start:
160,709,037 bp from pter      End:
160,724,611 bp from pter
Size:
15,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25 (See protein sequence)
Recommended Name: SLAM family member 7 precursor  
Size: 335 amino acids; 37421 Da
Subunit: Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro)
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=CAB76561.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8N6Y8 Q8ND32 Q9NY08 Q9NY23
Alternative splicing: 3 isoforms:  Q9NQ25-1   Q9NQ25-2   Q9NQ25-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLAMF7: NX_Q9NQ25

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NQ25

  • SLAMF7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067004.3  
    ENSEMBL proteins: 
     ENSP00000357022   ENSP00000357021   ENSP00000352281   ENSP00000405605   ENSP00000409965  
     ENSP00000416592   ENSP00000403294  

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    Uscn Proteins for SLAMF7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS--
    GO:0016021integral to membrane IEA--


    SLAMF7 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLAMF7 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q9NQ25

    ProtoNet protein and cluster: Q9NQ25

    1 Blocks protein family: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
    Function: Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated
    ERK-mediated pathway. May play a role in lymphocyte adhesion
    Function: Isoform 3 does not mediate any NK cell activation

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--


    SLAMF7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLAMF7:
     Decreased circadian period len 

    Animal Models:
         Mouse knock-out Slamf7tm1Vei for SLAMF7
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slamf7):
     immune system 

    SLAMF7 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLAMF7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLAMF7 (Q9NQ253 ENSP000003570224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1AO608803, ENSP000003601814I2D: score=2 STRING: ENSP00000360181
    MAKENSP000003130214STRING: ENSP00000313021
    TRIB2ENSP000001559264STRING: ENSP00000155926
    --ENSP000003915184STRING: ENSP00000391518
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS11802771
    GO:0030101natural killer cell activation NAS11698418
    GO:0032814regulation of natural killer cell activation IEA--
    GO:0042267natural killer cell mediated cytotoxicity NAS11698418


    SLAMF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLAMF7
    Search CenterWatch for drugs/clinical trials and news about SLAMF7 / SLAF7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLAMF7 gene: 
    NM_021181.3  

    Unigene Cluster for SLAMF7:

    SLAM family member 7
    Hs.517265  [show with all ESTs]
    Unigene Representative Sequence: AL713801
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488819 ENST00000466792 ENST00000368043(uc001fwq.3 uc001fwr.3 uc010pjo.2 uc010pjq.2)
    ENST00000368042(uc010pjn.2 uc001fws.3 uc010pjp.2 uc010pjr.2)
    ENST00000359331 ENST00000495334 ENST00000484221 ENST00000441662 ENST00000458602
    ENST00000444090 ENST00000458104

    miRNA
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    hsa-miR-3150b-3p hsa-miR-4263
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    Additional cDNA sequence: 

    AB027233.1 AF291815.1 AF390894.1 AJ271869.1 AJ276429.2 AK290706.1 AK292097.1 AK292148.1 
    AK298499.1 AK298548.1 AK301137.1 AK301432.1 AK301438.1 AL713801.1 AL833025.1 AL834424.1 
    AY358512.1 BC027867.1 

    10 DOTS entries:

    DT.105165  DT.100778463  DT.100024090  DT.309909  DT.121394217  DT.121394220  DT.40120590  DT.95157794 
    DT.95267725  DT.95157797 

    24/107 AceView cDNA sequences (see all 107):

    BE467670 AW059854 AW197989 CD364928 BP346211 CD366944 AW572670 AF291815 
    CB529471 AA381714 BC027867 CD364943 AW630293 AY358512 BQ712547 CA432799 
    CB529490 BQ053807 AW515147 BE671926 CD107362 AV713600 BU183701 AB027233 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF7 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                                  -                 -                 -     -                                                         
    SP2:                                                  -     -     -     -                 -     -     -                                                   
    SP3:                                                  -                 -                 -     -           -     -                                       
    SP4:                                                  -     -     -     -                 -     -                                                         
    SP5:                                                                                      -     -           -     -                                       


    ECgene alternative splicing isoforms for SLAMF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLAMF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAAGGGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLAMF7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartMyocardiumMature Cardiac FibroblastsEpicardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLAMF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLAMF7

    SOURCE GeneReport for Unigene cluster: Hs.517265

    UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
    Tissue specificity: Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine,
    stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in
    promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1

        SABiosciences Custom PCR Arrays for SLAMF7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLAMF7 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LY96
    --
    21(a)
    1 → many
    25(1373488-1374310)


    ENSEMBL Gene Tree for SLAMF7 (if available)
    TreeFam Gene Tree for SLAMF7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLAMF7 gene
    SLAMF92  SLAMF62  CD842  LY92  
    3 SIMAP similar genes for SLAMF7 using alignment to 6 protein entries:     SLAF7_HUMAN (see all proteins):
    SLAMF9    LY9    CD84

    SLAMF7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLAMF7
    PGOHUM00000245050


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    8 NCBI SNPs in SLAMF7 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411505411,2
    C,--160707364(+) AGCTA-/CCTCAG 1 -- us2k10--------
    rs668987181,2
    C--160710074(-) TTTTT-/TAAAGT 1 -- int13Minor allele frequency- T:0.17NA CSA 6
    rs613783861,2
    ----160721632(+) TCTCT-/CTCTCTCTCTCTCT
    CTCTCTCTATATATAT
    ATATA
    1 -- int10--------
    rs2006245901,2
    ----160721653(+) CTCTC-/TATA  
      TATATA
    TATAT
    1 -- int10--------
    rs286174671,2
    ----160721652(+) TCTCTA/CTATAT 1 -- int1 trp30--------
    rs2021647391,2
    ----160710074(+) ACTTTA/TAAAAA 1 -- int10--------
    rs105379871,2
    ----160721653(+) atata-/TAtatat 1 -- int10--------
    rs607570431,2
    ----160721653(+) ATATA-/TATA  
            
    CACAC
    1 -- int10--------

    HapMap Linkage Disequilibrium report for SLAMF7 (160709037 - 160724611 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLAMF7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLAMF7
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLAMF7 for disorders           About GeneDecksing

    OMIM gene information: 606625    OMIM disorders: --

    13 diseases for SLAMF7:    About MalaCards
    shipyard eye    pleural empyema    otitis media    systemic lupus erythematosus
    lupus erythematosus    multiple myeloma    rheumatoid arthritis    hepatitis b
    meningitis    myeloma    pneumonia    arthritis
    hepatitis

    Human Genome Epidemiology (HuGE) Navigator: SLAMF7 (2 documents)

    Export disorders for SLAMF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLAMF7 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with SLAMF7)
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    1. A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion. (PubMed id 11802771)1, 2, 3, 9 Murphy J.J.... Norton J.D. (2002)
    2. Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily. (PubMed id 11220635)1, 2, 3 Boles K.S. and Mathew P.A. (2001)
    3. Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. (PubMed id 15368295)1, 2, 9 Lee J.K.... Mathew P.A. (2004)
    4. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. (PubMed id 12242590)1, 2, 9 Tovar V.... Engel P. (2002)
    5. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. (PubMed id 11698418)1, 2, 9 Bouchon A.... Colonna M. (2001)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. (PubMed id 17878365)1, 9 Lee J.K....Mathew P.A. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57823 HGNC: 21394 AceView: SLAMF7 Ensembl:ENSG00000026751 euGenes: HUgn57823
    ECgene: SLAMF7 H-InvDB: SLAMF7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLAMF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLAMF7 gene:
    Search GeneIP for patents involving SLAMF7

    GeneCards and IP:
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