Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLAMF7 Gene

protein-coding   GIFtS: 56
GCID: GC01P160709

SLAM Family Member 7

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SLAM Family Member 71 2     19A2
CRACC2 3 5     19A24 Protein2
CS12 3 5     CD3192
Membrane Protein FOAP-122 3     CD2-Like Receptor Activating Cytotoxic Cells2
Protein 19A2 3     Novel LY9 (Lymphocyte Antigen 9) Like Protein2
CD2 Subset 12 3     CD319 Antigen3
CD2-Like Receptor-Activating Cytotoxic Cells2 3     Novel Ly93

External Ids:    HGNC: 213941   Entrez Gene: 578232   Ensembl: ENSG000000267517   OMIM: 6066255   UniProtKB: Q9NQ253   
ORGUL members:         

Export aliases for SLAMF7 gene to outside databases

Previous GC identifers: GC01P157925 GC01P157522 GC01P158975 GC01P132065


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLAMF7 Gene:
SLAMF7 (SLAM family member 7) is a protein-coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF9.

UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
Function: Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated
ERK-mediated pathway. May play a role in lymphocyte adhesion
Function: Isoform 3 does not mediate any NK cell activation

Gene Wiki entry for SLAMF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLAMF7 gene promoter:
         TBP   STAT1   POU3F1   Pax-6   STAT1beta   LUN-1   LCR-F1   C/EBPalpha   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLAMF7 promoter sequence
   Search Chromatin IP Primers for SLAMF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLAMF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1-q24.1   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.1-q24.1

SLAMF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAMF7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P160709:  view genomic region     (about GC identifiers)

Start:
160,709,037 bp from pter      End:
160,724,611 bp from pter
Size:
15,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25 (See protein sequence)
Recommended Name: SLAM family member 7 precursor  
Size: 335 amino acids; 37421 Da
Subunit: Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro)
Sequence caution: Sequence=CAB76561.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8N6Y8 Q8ND32 Q9NY08 Q9NY23
Alternative splicing: 3 isoforms:  Q9NQ25-1   Q9NQ25-2   Q9NQ25-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLAMF7: NX_Q9NQ25

Explore proteomics data for SLAMF7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn98, Asn142, Asn148, Asn172, Asn176, Asn204
  • Modification sites at PhosphoSitePlus

  • See SLAMF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001269517.1  NP_001269518.1  NP_001269519.1  NP_001269520.1  NP_001269521.1  NP_001269522.1  NP_001269523.1  NP_001269524.1  
    NP_001269525.1  NP_067004.3  

    ENSEMBL proteins: 
     ENSP00000357022   ENSP00000357021   ENSP00000352281   ENSP00000473590   ENSP00000405605  
     ENSP00000409965   ENSP00000416592   ENSP00000403294  

    SLAMF7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLAMF7
    OriGene Protein Over-expression Lysate for SLAMF7
    OriGene MassSpec for SLAMF7
    OriGene Custom Protein Services for SLAMF7
    GenScript Custom Purified and Recombinant Proteins Services for SLAMF7
    Novus Biologicals SLAMF7 Proteins
    Novus Biologicals SLAMF7 Lysates
    Sino Biological Recombinant Protein for SLAMF7
    Sino Biological Cell Lysate for SLAMF7
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLAMF7

     
    Search eBioscience for Proteins for SLAMF7 

     
    antibodies-online proteins for SLAMF7 (12 products) 

     
    antibodies-online peptides for SLAMF7

    SLAMF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SLAMF7 (CRACC/SLAMF7)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLAMF7
    Novus Biologicals SLAMF7 Antibodies
    Abcam antibodies for SLAMF7
    Cloud-Clone Corp. Antibodies for SLAMF7
    ThermoFisher Antibodies for SLAMF7
    LSBio Antibodies in human, mouse, rat for SLAMF7
    antibodies-online antibodies for SLAMF7 (28 products) 

    SLAMF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLAMF7
    R&D Systems Proteome Profiler Antibody Arrays for SLAMF7 (CRACC/SLAMF7)
    GenScript Custom Assay Services for SLAMF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLAMF7
    Cloud-Clone Corp. CLIAs for SLAMF7
    Search eBioscience for ELISAs for SLAMF7 
    antibodies-online kits for SLAMF7 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9NQ25

    ProtoNet protein and cluster: Q9NQ25

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    Find genes that share domains with SLAMF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAF7_HUMAN, Q9NQ25
    Function: Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated
    ERK-mediated pathway. May play a role in lymphocyte adhesion
    Function: Isoform 3 does not mediate any NK cell activation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SLAMF7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLAMF7:
     Decreased circadian period len 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slamf7):
     hematopoietic system  immune system 

    Find genes that share phenotypes with SLAMF7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slamf7tm1Vei for SLAMF7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLAMF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLAMF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLAMF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLAMF7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SLAMF7 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SLAMF7:
    hsa-miR-3150b-3p hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLAMF7
    Predesigned siRNA for gene silencing in human, mouse, rat SLAMF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLAMF7

    Clone
    Products:
         
    OriGene clones in human, mouse for SLAMF7 (see all 7)
    OriGene ORF clones in mouse, rat for SLAMF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLAMF7 (NM_021181)
    Sino Biological Human cDNA Clone for SLAMF7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAMF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLAMF7
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLAMF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SLAF7_HUMAN, Q9NQ25: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLAMF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLAMF7
    Interactions:

        GeneGlobe Interaction Network for SLAMF7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLAMF7 (Q9NQ253 ENSP000003570224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1AO608803, ENSP000003601814I2D: score=2 STRING: ENSP00000360181
    MAKENSP000003130214STRING: ENSP00000313021
    TRIB2ENSP000001559264STRING: ENSP00000155926
    --ENSP000003915184STRING: ENSP00000391518
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion NAS11802771
    GO:0030101natural killer cell activation NAS11698418
    GO:0032814regulation of natural killer cell activation IEA--
    GO:0042267natural killer cell mediated cytotoxicity NAS11698418

    Find genes that share ontologies with SLAMF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLAMF7 (SLAF7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLAMF7 gene (10 alternative transcripts): 
    NM_001282588.1  NM_001282589.1  NM_001282590.1  NM_001282591.1  NM_001282592.1  NM_001282593.1  NM_001282594.1  NM_001282595.1  
    NM_001282596.1  NM_021181.4  

    Unigene Cluster for SLAMF7:

    SLAM family member 7
    Hs.517265  [show with all ESTs]
    Unigene Representative Sequence: AL713801
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488819 ENST00000368043(uc001fwq.3 uc001fwr.3 uc010pjo.2 uc010pjq.2)
    ENST00000368042(uc010pjn.2 uc001fws.3 uc010pjp.2 uc010pjr.2)
    ENST00000359331 ENST00000495334 ENST00000484221 ENST00000441662 ENST00000458602
    ENST00000444090 ENST00000458104
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLAMF7 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SLAMF7:
    hsa-miR-3150b-3p hsa-miR-4263
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLAMF7
    Predesigned siRNA for gene silencing in human, mouse, rat SLAMF7
    Clone
    Products:
         
    OriGene clones in human, mouse for SLAMF7 (see all 7)
    OriGene ORF clones in mouse, rat for SLAMF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLAMF7 (NM_021181)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAMF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLAMF7
    OriGene qSTAR qPCR primer pairs in human, mouse for SLAMF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLAMF7
      QuantiTect SYBR Green Assays in human, mouse, rat SLAMF7
      QuantiFast Probe-based Assays in human, mouse, rat SLAMF7

    Additional mRNA sequence: 

    AB027233.1 AF291815.1 AF390894.1 AJ271869.1 AJ276429.2 AK290706.1 AK292097.1 AK292148.1 
    AK298499.1 AK298548.1 AK301137.1 AK301432.1 AK301438.1 AL713801.1 AL833025.1 AL834424.1 
    AY358512.1 BC027867.1 

    10 DOTS entries:

    DT.105165  DT.100778463  DT.100024090  DT.309909  DT.121394217  DT.121394220  DT.40120590  DT.95157794 
    DT.95267725  DT.95157797 

    Selected AceView cDNA sequences (see all 107):

    CB529471 AW630293 AW059854 BE467670 AW515147 CB529490 CD366944 CA432799 
    AW572670 CD364943 BP346211 BQ053807 AA381714 AY358512 BC027867 BE671926 
    BQ712547 AF291815 AW197989 CD364928 BX279875 AI521522 AF390894 BQ000581 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF7 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                                  -                 -                 -     -                                                         
    SP2:                                                  -     -     -     -                 -     -     -                                                   
    SP3:                                                  -                 -                 -     -           -     -                                       
    SP4:                                                  -     -     -     -                 -     -                                                         
    SP5:                                                                                      -     -           -     -                                       


    ECgene alternative splicing isoforms for SLAMF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLAMF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAAGGGGA
    SLAMF7 Expression
    About this image


    SLAMF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
    SLAMF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLAMF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517265

    UniProtKB/Swiss-Prot: SLAF7_HUMAN, Q9NQ25
    Tissue specificity: Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine,
    stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not
    in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1

        Custom PCR Arrays for SLAMF7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLAMF7
    OriGene qSTAR qPCR primer pairs in human, mouse for SLAMF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLAMF7
    QuantiTect SYBR Green Assays in human, mouse, rat SLAMF7
    QuantiFast Probe-based Assays in human, mouse, rat SLAMF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SLAMF7 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slamf71 , 5 SLAM family member 71, 5 67.68(n)1
    49.85(a)1
      1 (79.54 cM)5
    753451  NM_144539.51  NP_653122.21 
     1716349255 


    ENSEMBL Gene Tree for SLAMF7 (if available)
    TreeFam Gene Tree for SLAMF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLAMF7 gene
    SLAMF92  SLAMF62  CD842  LY92  
    3 SIMAP similar genes for SLAMF7 using alignment to 7 protein entries:     SLAF7_HUMAN (see all proteins):
    SLAMF9    LY9    CD84

    Find genes that share paralogs with SLAMF7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLAMF7
    PGOHUM00000245050


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLAMF7 (see all 435)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668987181,2
    C--160710074(-) TTTTT-/TAAAGT 1 -- int13Minor allele frequency- T:0.17NA CSA 6
    rs730159211,2
    C,F--167203024(+) GCTTAT/ACATAA 1 -- us2k13Minor allele frequency- A:0.07WA CSA 122
    rs1910888261,2
    --167203032(+) TAAAAA/GAATTC 1 -- us2k10--------
    rs1436830231,2
    C--167203067(+) GAAATG/TATTAA 1 -- us2k10--------
    rs1841465161,2
    --167203110(+) CATACC/TTGTAA 1 -- us2k10--------
    rs1885024881,2
    --167203185(+) GCCAAA/CATGGC 1 -- us2k10--------
    rs1143099291,2
    C,F--167203220(+) CAAAAA/TGTAGG 1 -- us2k12Minor allele frequency- T:0.07WA EA 238
    rs20907561,2
    C--167203299(-) TCCGCC/TTCCTG 1 -- us2k13Minor allele frequency- T:0.17NA WA 6
    rs22223181,2
    C--167203302(-) ATCTCC/TGCCTC 1 -- us2k1 tfbs30--------
    rs1816368961,2
    --167203365(+) ACTTCA/GTCCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLAMF7 (160709037 - 160724611 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLAMF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831714CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLAMF7
    DNA2.0 Custom Variant and Variant Library Synthesis for SLAMF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606625    OMIM disorders: --


    Find genes that share disorders with SLAMF7           About GenesLikeMe

    Genetic Association Database (GAD): SLAMF7
    Human Genome Epidemiology (HuGE) Navigator: SLAMF7 (2 documents)

    Export disorders for SLAMF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLAMF7 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with SLAMF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion. (PubMed id 11802771)1, 2, 3, 9 Murphy J.J.... Norton J.D. (Biochem. J. 2002)
    2. Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily. (PubMed id 11220635)1, 2, 3 Boles K.S. and Mathew P.A. (Immunogenetics 2001)
    3. Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. (PubMed id 15368295)1, 2, 9 Lee J.K.... Mathew P.A. (Eur. J. Immunol. 2004)
    4. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. (PubMed id 12242590)1, 2, 9 Tovar V.... Engel P. (Immunogenetics 2002)
    5. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. (PubMed id 11698418)1, 2, 9 Bouchon A.... Colonna M. (J. Immunol. 2001)
    6. Association of LY9 in UK and Canadian SLE families. (PubMed id 18216865)1, 4 Cunninghame Graham D.S....Rioux J.D. (Genes Immun. 2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57823 HGNC: 21394 AceView: SLAMF7 Ensembl:ENSG00000026751 euGenes: HUgn57823
    ECgene: SLAMF7 H-InvDB: SLAMF7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLAMF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLAMF7 gene:
    Search GeneIP for patents involving SLAMF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for SLAMF7 (CRACC/SLAMF7)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for SLAMF7 (CRACC/SLAMF7)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLAMF7  
     OriGene qPCR primer pairs and template standards for SLAMF7   OriGene Protein Over-expression Lysate for SLAMF7  
     OriGene MassSpec for SLAMF7   OriGene clones in human, mouse for SLAMF7  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLAMF7   OriGene Purified Protein for SLAMF7  
     OriGene ORF clones in mouse, rat for SLAMF7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLAMF7   OriGene Custom Protein Services for SLAMF7  

     
     
     Block miRNA regulation of human, mouse, rat SLAMF7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLAMF7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLAMF7 Predesigned siRNA for gene silencing in human, mouse, rat SLAMF7
     QuantiFast Probe-based Assays in human, mouse, rat SLAMF7 QuantiTect SYBR Green Assays in human, mouse, rat SLAMF7
     Custom PCR Arrays for SLAMF7 Search Chromatin IP Primers for SLAMF7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLAMF7  GeneGlobe Interaction Network for SLAMF7
     Regulatory tfbs in SLAMF7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLAMF7 GenScript cDNA clones with any tag delivered in your preferred vector for SLAMF7
     GenScript Custom Assay Services for SLAMF7 GenScript Custom overexpressing Cell Line Services for SLAMF7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLAMF7 (SLAF7)
     Proteins for SLAMF7
     Cell Lysates for SLAMF7
     cDNA Clones for SLAMF7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLAMF7 antibodies
     SLAMF7 proteins
     SLAMF7 lysates
     Antibodies for SLAMF7
     See all of Abcam's Antibodies, Kits and Proteins for SLAMF7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SLAMF7
     Antibodies for SLAMF7
     ELISAs for SLAMF7
     CLIAs for SLAMF7



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLAMF7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF7
     SwitchGear 3'UTR luciferase reporter plasmids for SLAMF7
     SwitchGear Promoter luciferase reporter plasmids for SLAMF7
     ThermoFisher Antibodies for SLAMF7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLAMF7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLAMF7
     LSBio Antibodies in human, mouse, rat for SLAMF7
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLAMF7
      Search eBioscience for proteins for SLAMF7
      Search eBioscience for elisas for SLAMF7
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for SLAMF7 (28 products)
     antibodies-online kits for SLAMF7 (6 products)
     antibodies-online peptides for SLAMF7
     antibodies-online proteins for SLAMF7 (12 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLAMF7 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4