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Aliases for SLAMF7 Gene

Aliases for SLAMF7 Gene

  • SLAM Family Member 7 2 3
  • CRACC 3 4 6
  • CS1 3 4 6
  • CD2-Like Receptor-Activating Cytotoxic Cells 3 4
  • Membrane Protein FOAP-12 3 4
  • CD2 Subset 1 3 4
  • Protein 19A 3 4
  • Novel LY9 (Lymphocyte Antigen 9) Like Protein 3
  • CD2-Like Receptor Activating Cytotoxic Cells 3
  • 19A24 Protein 3
  • CD319 Antigen 4
  • Novel Ly9 4
  • CD319 3
  • 19A 3

External Ids for SLAMF7 Gene

Previous GeneCards Identifiers for SLAMF7 Gene

  • GC01P157925
  • GC01P157522
  • GC01P158975
  • GC01P132065

Summaries for SLAMF7 Gene

GeneCards Summary for SLAMF7 Gene

SLAMF7 (SLAM Family Member 7) is a Protein Coding gene. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.

UniProtKB/Swiss-Prot for SLAMF7 Gene

  • Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion

  • Isoform 3 does not mediate any NK cell activation

Gene Wiki entry for SLAMF7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF7 Gene

Genomics for SLAMF7 Gene

Regulatory Elements for SLAMF7 Gene

Genomic Location for SLAMF7 Gene

160,739,057 bp from pter
160,754,821 bp from pter
15,765 bases
Plus strand

Genomic View for SLAMF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLAMF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF7 Gene

Proteins for SLAMF7 Gene

  • Protein details for SLAMF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAM family member 7
    Protein Accession:
    Secondary Accessions:
    • A8K3U1
    • B4DPU4
    • B4DPY3
    • B4DWA3
    • Q8N6Y8
    • Q8ND32
    • Q9NY08
    • Q9NY23

    Protein attributes for SLAMF7 Gene

    335 amino acids
    Molecular mass:
    37421 Da
    Quaternary structure:
    • Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro).
    • Sequence=CAB76561.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for SLAMF7 Gene

neXtProt entry for SLAMF7 Gene

Proteomics data for SLAMF7 Gene at MOPED

Post-translational modifications for SLAMF7 Gene

  • Glycosylation at Asn98, Asn142, Asn148, Asn172, Asn176, and Asn204
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SLAMF7 (CRACC/SLAMF7)

No data available for DME Specific Peptides for SLAMF7 Gene

Domains for SLAMF7 Gene

Gene Families for SLAMF7 Gene

  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SLAMF7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NQ25
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SLAMF7: view

Function for SLAMF7 Gene

Molecular function for SLAMF7 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion
UniProtKB/Swiss-Prot Function:
Isoform 3 does not mediate any NK cell activation

Gene Ontology (GO) - Molecular Function for SLAMF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLAMF7: view

Phenotypes for SLAMF7 Gene

MGI mutant phenotypes for SLAMF7:
inferred from 1 alleles
GenomeRNAi human phenotypes for SLAMF7:
genes like me logo Genes that share phenotypes with SLAMF7: view

Animal Models for SLAMF7 Gene

MGI Knock Outs for SLAMF7:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLAMF7 Gene

Localization for SLAMF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SLAMF7 Gene COMPARTMENTS Subcellular localization image for SLAMF7 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLAMF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF7: view

Pathways for SLAMF7 Gene

SuperPathways for SLAMF7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLAMF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 11802771
GO:0030101 natural killer cell activation NAS 11698418
GO:0042267 natural killer cell mediated cytotoxicity NAS 11698418
genes like me logo Genes that share ontologies with SLAMF7: view

No data available for Pathways by source for SLAMF7 Gene

Transcripts for SLAMF7 Gene

Unigene Clusters for SLAMF7 Gene

SLAM family member 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLAMF7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP12: - -
SP13: - - - -

Relevant External Links for SLAMF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAMF7 Gene

mRNA expression in normal human tissues for SLAMF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF7 Gene

This gene is overexpressed in Whole Blood (6.4) and Spleen (4.7).

Protein differential expression in normal tissues for SLAMF7 Gene

This gene is overexpressed in Plasma (59.8) and Pancreatic juice (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLAMF7 Gene

SOURCE GeneReport for Unigene cluster for SLAMF7 Gene Hs.517265

mRNA Expression by UniProt/SwissProt for SLAMF7 Gene

Tissue specificity: Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1.
genes like me logo Genes that share expressions with SLAMF7: view

Expression partners for SLAMF7 Gene

In Situ Assay Products

Orthologs for SLAMF7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLAMF7 35
  • 75.5 (n)
  • 60.54 (a)
  • 60 (a)
(Canis familiaris)
Mammalia SLAMF7 35
  • 76.13 (n)
  • 61.03 (a)
  • 58 (a)
(Mus musculus)
Mammalia Slamf7 35
  • 67.68 (n)
  • 49.85 (a)
Slamf7 16
Slamf7 36
  • 49 (a)
(Pan troglodytes)
Mammalia SLAMF7 35
  • 98.81 (n)
  • 98.21 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Slamf7 35
  • 66.98 (n)
  • 51.57 (a)
(Monodelphis domestica)
Mammalia SLAMF7 36
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
Species with no ortholog for SLAMF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF7 Gene

Gene Tree for SLAMF7 (if available)
Gene Tree for SLAMF7 (if available)

Paralogs for SLAMF7 Gene

Paralogs for SLAMF7 Gene

Selected SIMAP similar genes for SLAMF7 Gene using alignment to 7 proteins: Pseudogenes for SLAMF7 Gene

genes like me logo Genes that share paralogs with SLAMF7: view

Variants for SLAMF7 Gene

Sequence variations from dbSNP and Humsavar for SLAMF7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs484703 -- 160,737,683(-) ttttt(A/G)gacga upstream-variant-2KB
rs489286 -- 160,752,760(+) CAGTA(A/G)TGGTA intron-variant
rs495706 -- 160,753,466(+) CTATA(A/G)AAATG utr-variant-3-prime
rs508744 -- 160,737,989(-) atatt(A/G)cattt upstream-variant-2KB
rs510131 -- 160,740,469(+) GCCCT(C/G)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF7 Gene

Variant ID Type Subtype PubMed ID
nsv831714 CNV Gain 17160897

Relevant External Links for SLAMF7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF7 Gene

Disorders for SLAMF7 Gene

Relevant External Links for SLAMF7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SLAMF7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLAMF7 Gene

Publications for SLAMF7 Gene

  1. A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion. (PMID: 11802771) Murphy J.J. … Norton J.D. (Biochem. J. 2002) 2 3 4 23
  2. Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. (PMID: 15368295) Lee J.K. … Mathew P.A. (Eur. J. Immunol. 2004) 3 4 23
  3. Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily. (PMID: 11220635) Boles K.S. … Mathew P.A. (Immunogenetics 2001) 2 3 4
  4. Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors. (PMID: 12242590) Tovar V. … Engel P. (Immunogenetics 2002) 3 4 23
  5. Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. (PMID: 11698418) Bouchon A. … Colonna M. (J. Immunol. 2001) 3 4 23

Products for SLAMF7 Gene

Sources for SLAMF7 Gene

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