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Aliases for SLAMF7 Gene

Aliases for SLAMF7 Gene

  • SLAM Family Member 7 2 3 5
  • CD2-Like Receptor-Activating Cytotoxic Cells 3 4
  • Membrane Protein FOAP-12 3 4
  • CD2 Subset 1 3 4
  • Protein 19A 3 4
  • CRACC 3 4
  • CS1 3 4
  • Novel LY9 (Lymphocyte Antigen 9) Like Protein 3
  • CD2-Like Receptor Activating Cytotoxic Cells 3
  • 19A24 Protein 3
  • CD319 Antigen 4
  • Novel Ly9 4
  • CD319 3
  • 19A 3

External Ids for SLAMF7 Gene

Previous GeneCards Identifiers for SLAMF7 Gene

  • GC01P157925
  • GC01P157522
  • GC01P158975
  • GC01P132065

Summaries for SLAMF7 Gene

GeneCards Summary for SLAMF7 Gene

SLAMF7 (SLAM Family Member 7) is a Protein Coding gene. Diseases associated with SLAMF7 include Systemic Lupus Erythematosus. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and Immune System. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF6.

UniProtKB/Swiss-Prot for SLAMF7 Gene

  • Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).

  • Isoform 3 does not mediate any NK cell activation.

Gene Wiki entry for SLAMF7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF7 Gene

Genomics for SLAMF7 Gene

Regulatory Elements for SLAMF7 Gene

Enhancers for SLAMF7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLAMF7 on UCSC Golden Path with GeneCards custom track

Promoters for SLAMF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLAMF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLAMF7 Gene

Chromosome:
1
Start:
160,739,057 bp from pter
End:
160,754,821 bp from pter
Size:
15,765 bases
Orientation:
Plus strand

Genomic View for SLAMF7 Gene

Genes around SLAMF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF7 Gene

Proteins for SLAMF7 Gene

  • Protein details for SLAMF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ25-SLAF7_HUMAN
    Recommended name:
    SLAM family member 7
    Protein Accession:
    Q9NQ25
    Secondary Accessions:
    • A8K3U1
    • B4DPU4
    • B4DPY3
    • B4DWA3
    • Q8N6Y8
    • Q8ND32
    • Q9NY08
    • Q9NY23

    Protein attributes for SLAMF7 Gene

    Size:
    335 amino acids
    Molecular mass:
    37421 Da
    Quaternary structure:
    • Isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro); low affinity binding, the physiological relevance of the interaction is questioned. Interacts with SH2D1B; in NK cells (PubMed:16339536). Interacts (via ITSM phosphorylated on Tyr-302) with SH2D1B, PTPN6/SHP-1, PTPN11/SHP-2, INPP5D/SHIP1, CSK and FYN (By similarity).
    Miscellaneous:
    • Proposed to be involved in systemic lupus erythematosus (SLE) disease process.
    SequenceCaution:
    • Sequence=CAB76561.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for SLAMF7 Gene

neXtProt entry for SLAMF7 Gene

Proteomics data for SLAMF7 Gene at MOPED

Post-translational modifications for SLAMF7 Gene

  • Glycosylation at Asn 98, Asn 142, Asn 148, Asn 172, Asn 176, and Asn 204
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SLAMF7 (CRACC/SLAMF7)

No data available for DME Specific Peptides for SLAMF7 Gene

Domains & Families for SLAMF7 Gene

Gene Families for SLAMF7 Gene

Protein Domains for SLAMF7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQ25

UniProtKB/Swiss-Prot:

SLAF7_HUMAN :
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
Domain:
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SLAMF7: view

Function for SLAMF7 Gene

Molecular function for SLAMF7 Gene

UniProtKB/Swiss-Prot Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
UniProtKB/Swiss-Prot Function:
Isoform 3 does not mediate any NK cell activation.
genes like me logo Genes that share phenotypes with SLAMF7: view

Animal Models for SLAMF7 Gene

MGI Knock Outs for SLAMF7:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLAMF7

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLAMF7 Gene

Localization for SLAMF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAMF7 Gene COMPARTMENTS Subcellular localization image for SLAMF7 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SLAMF7 Gene

Pathways & Interactions for SLAMF7 Gene

genes like me logo Genes that share pathways with SLAMF7: view

Gene Ontology (GO) - Biological Process for SLAMF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030101 natural killer cell activation NAS 11698418
genes like me logo Genes that share ontologies with SLAMF7: view

No data available for SIGNOR curated interactions for SLAMF7 Gene

Drugs & Compounds for SLAMF7 Gene

(1) Drugs for SLAMF7 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ELOTUZUMAB Pharma 0
genes like me logo Genes that share compounds with SLAMF7: view

Transcripts for SLAMF7 Gene

Unigene Clusters for SLAMF7 Gene

SLAM family member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF7 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11:
SP12: - -
SP13: - - - -

Relevant External Links for SLAMF7 Gene

GeneLoc Exon Structure for
SLAMF7
ECgene alternative splicing isoforms for
SLAMF7

Expression for SLAMF7 Gene

mRNA expression in normal human tissues for SLAMF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF7 Gene

This gene is overexpressed in Whole Blood (x6.4) and Spleen (x4.7).

Protein differential expression in normal tissues from HIPED for SLAMF7 Gene

This gene is overexpressed in Plasma (59.8) and Pancreatic juice (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLAMF7 Gene



SOURCE GeneReport for Unigene cluster for SLAMF7 Gene Hs.517265

mRNA Expression by UniProt/SwissProt for SLAMF7 Gene

Q9NQ25-SLAF7_HUMAN
Tissue specificity: Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1.
genes like me logo Genes that share expression patterns with SLAMF7: view

Protein tissue co-expression partners for SLAMF7 Gene

Primer Products

Orthologs for SLAMF7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLAMF7 35
  • 75.5 (n)
  • 60.54 (a)
SLAMF7 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLAMF7 35
  • 76.13 (n)
  • 61.03 (a)
SLAMF7 36
  • 58 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slamf7 35
  • 67.68 (n)
  • 49.85 (a)
Slamf7 16
Slamf7 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLAMF7 35
  • 98.81 (n)
  • 98.21 (a)
SLAMF7 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slamf7 35
  • 66.98 (n)
  • 51.57 (a)
oppossum
(Monodelphis domestica)
Mammalia SLAMF7 36
  • 26 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
ManyToMany
Species with no ortholog for SLAMF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF7 Gene

ENSEMBL:
Gene Tree for SLAMF7 (if available)
TreeFam:
Gene Tree for SLAMF7 (if available)

Paralogs for SLAMF7 Gene

Paralogs for SLAMF7 Gene

(3) SIMAP similar genes for SLAMF7 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SLAMF7 Gene

genes like me logo Genes that share paralogs with SLAMF7: view

Variants for SLAMF7 Gene

Sequence variations from dbSNP and Humsavar for SLAMF7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35325048 - 160,749,967(-) ATTAT(A/G)GGACT intron-variant, reference, missense
rs2295617 - 160,752,217(+) AAATA(C/T)GGTTT reference, synonymous-codon, missense
rs484703 -- 160,737,683(-) ttttt(A/G)gacga upstream-variant-2KB
rs489286 -- 160,752,760(+) CAGTA(A/G)TGGTA intron-variant
rs535622 -- 160,740,955(+) CAAGC(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF7 Gene

Variant ID Type Subtype PubMed ID
nsv831714 CNV Gain 17160897

Variation tolerance for SLAMF7 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.70% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLAMF7 Gene

Disorders for SLAMF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLAMF7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLAMF7

Genetic Association Database (GAD)
SLAMF7
Human Genome Epidemiology (HuGE) Navigator
SLAMF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLAMF7
genes like me logo Genes that share disorders with SLAMF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLAMF7 Gene

Publications for SLAMF7 Gene

  1. A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion. (PMID: 11802771) Murphy J.J. … Norton J.D. (Biochem. J. 2002) 2 3 4 23 67
  2. Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis. (PMID: 19904767) Fasth A.E. … MalmstrAPm V. (Eur. J. Immunol. 2010) 3 23
  3. CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma. (PMID: 18451245) Hsi E.D. … Williams M.B. (Clin. Cancer Res. 2008) 3 23
  4. CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. (PMID: 17878365) Lee J.K. … Mathew P.A. (J. Immunol. 2007) 3 23
  5. Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. (PMID: 15368295) Lee J.K. … Mathew P.A. (Eur. J. Immunol. 2004) 3 23

Products for SLAMF7 Gene

Sources for SLAMF7 Gene

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