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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLAMF6 Gene

protein-coding   GIFtS: 53
GCID: GC01M160454

SLAM Family Member 6

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SLAM Family Member 61 2     KALIb2
Activating NK Receptor2 3     Ly1082
KALI2 3     SF20002
NK-T-B-antigen2 3     Natural Killer-, T- And B-Cell Antigen2
NTB-A2 3     NTBA Receptor2
NTBA2 5     CD352 Antigen3
CD3522     

External Ids:    HGNC: 213921   Entrez Gene: 1148362   Ensembl: ENSG000001627397   OMIM: 6064465   UniProtKB: Q96DU33   

Export aliases for SLAMF6 gene to outside databases

Previous GC identifers: GC01M157671 GC01M157267 GC01M158721 GC01M131811


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLAMF6 Gene:
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the
immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It
undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as
well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell
activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by RefSeq, May
2010)

GeneCards Summary for SLAMF6 Gene: 
SLAMF6 (SLAM family member 6) is a protein-coding gene. Diseases associated with SLAMF6 include griscelli syndrome, and bare lymphocyte syndrome. GO annotations related to this gene include receptor activity. An important paralog of this gene is SLAMF9.

UniProtKB/Swiss-Prot: SLAF6_HUMAN, Q96DU3
Function: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of
natural cytotoxicity receptors

Gene Wiki entry for SLAMF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLAMF6 gene promoter:
         Pax-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Pax-2a   POU3F2   FOXJ2 (long isoform)   FOXJ2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLAMF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLAMF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAMF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.1

SLAMF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAMF6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160454:  view genomic region     (about GC identifiers)

Start:
160,454,820 bp from pter      End:
160,493,052 bp from pter
Size:
38,233 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLAF6_HUMAN, Q96DU3 (See protein sequence)
Recommended Name: SLAM family member 6 precursor  
Size: 332 amino acids; 37345 Da
Subunit: Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable)
1 PDB 3D structure from and Proteopedia for SLAMF6:
2IF7 (3D)    
Secondary accessions: A6NMW2 B2R8X8 Q14CF0 Q5TAS4 Q5TAS6 Q5TAT3 Q96DV0
Alternative splicing: 3 isoforms:  Q96DU3-1   Q96DU3-2   Q96DU3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLAMF6: NX_Q96DU3

Explore proteomics data for SLAMF6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DU3

  • SLAMF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLAMF6 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001171643.1  NP_001171644.1  NP_001171645.1  NP_443163.1  

    ENSEMBL proteins: 
     ENSP00000357038   ENSP00000357036   ENSP00000357034  

    Human Recombinant Protein Products for SLAMF6: 
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    Sino Biological Recombinant Protein for SLAMF6
    Sino Biological Cell Lysate for SLAMF6 
    ProSpec Recombinant Protein for SLAMF6
    Cloud-Clone Corp. Proteins for SLAMF6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    SLAMF6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR015631 SLAM_fam_rcpts
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q96DU3

    ProtoNet protein and cluster: Q96DU3

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: SLAF6_HUMAN, Q96DU3
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain


    SLAMF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAF6_HUMAN, Q96DU3
    Function: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of
    natural cytotoxicity receptors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
         
    SLAMF6 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slamf6):
     homeostasis/metabolism  immune system  mortality/aging  normal 

    SLAMF6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLAMF6: Slamf6tm1Dhow Slamf6tm1Lex Slamf6tm1Pls

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLAMF6 
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAMF6 (see all 17):
    hsa-miR-485-5p hsa-miR-4307 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLAMF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SLAMF6 (Q96DU33 ENSP000003570384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061243, ENSP000003409444I2D: score=2 STRING: ENSP00000340944
    PTPN6P293503, ENSP000003915924I2D: score=2 STRING: ENSP00000391592
    ZAP70P434033, ENSP000002649724I2D: score=1 STRING: ENSP00000264972
    SH2D1AO608803, ENSP000003601814I2D: score=3 STRING: ENSP00000360181
    DAPP1ENSP000002964144STRING: ENSP00000296414
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLAMF6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLAMF6 (SLAF6)

    1 Novoseek inferred chemical compound relationship for SLAMF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 24.6 3 11489943 (2), 17339454 (1)

    Search CenterWatch for drugs/clinical trials and news about SLAMF6 / SLAF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLAMF6 gene (4 alternative transcripts): 
    NM_001184714.1  NM_001184715.1  NM_001184716.1  NM_052931.4  

    Unigene Cluster for SLAMF6:

    SLAM family member 6
    Hs.492348  [show with all ESTs]
    Unigene Representative Sequence: NM_001184714
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368059(uc001fwe.2 uc010pji.2 uc001fwd.2 uc010pjh.2 uc010pjj.2 uc009wtm.2)
    ENST00000368057 ENST00000368055
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLAMF6
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAMF6 (see all 17):
    hsa-miR-485-5p hsa-miR-4307 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-28-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF6 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLAMF6
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    Additional mRNA sequence: 

    AJ306388.1 AK125624.1 AK300013.1 AK301026.1 AK303990.1 AK310085.1 AK313549.1 AL832854.1 
    AY358159.1 BC113893.1 BC114495.1 

    5 DOTS entries:

    DT.102821872  DT.86858666  DT.40248250  DT.95246608  DT.95264526 

    24/26 AceView cDNA sequences (see all 26):

    BP344056 AK125624 AJ306388 AL832854 AY358159 NM_052931 BE242910 AW851581 
    AW401768 CD635373 AW402723 AA361286 BF108763 CD635377 BP338062 BI834685 
    AI445224 AJ277141 AW408124 CD635375 AW575067 AI445297 BU430881 BG540789 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF6    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                                            -                                             
    SP2:                                            -                                             
    SP3:                                            -                                             
    SP4:                          -     -           -                                             
    SP5:                          -                                                               


    ECgene alternative splicing isoforms for SLAMF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLAMF6 expression in normal human tissues (normalized intensities)      SLAMF6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATGTATT
    SLAMF6 Expression
    About this image


    SLAMF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Spleen (Hematopoietic System)

    See SLAMF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLAMF6

    SOURCE GeneReport for Unigene cluster: Hs.492348

    UniProtKB/Swiss-Prot: SLAF6_HUMAN, Q96DU3
    Tissue specificity: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLAMF6 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slamf61 , 5 SLAM family member 61, 5 64.81(n)1
    46.41(a)1
      1 (79.54 cM)5
    309251  NM_030710.21  NP_109635.11 
     1719175375 
    chicken
    (Gallus gallus)
    Aves --
    --
    21(a)
    1 → many
    25(1223442-1225768)


    ENSEMBL Gene Tree for SLAMF6 (if available)
    TreeFam Gene Tree for SLAMF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLAMF6 gene
    SLAMF92  SLAMF72  CD842  LY92  

    SLAMF6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLAMF6
    PGOHUM00000245049


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/862 SNPs in SLAMF6 are shown (see all 862)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809651251,2
    --160454339(+) ATTATG/TTCAGT 4 -- ds50010--------
    rs1850406761,2
    --160454351(+) TTTCCC/TCATTC 4 -- ds50010--------
    rs1901217761,2
    --160454370(+) CAACCC/TCTTCC 4 -- ds50010--------
    rs125660571,2
    C,A,H--160454460(+) TCAGTG/AATAAT 4 -- ds50018Minor allele frequency- A:0.40NA CSA WA EA 370
    rs1831098331,2
    C--160454594(+) TATTTC/TATTTT 4 -- ds50010--------
    rs1429955831,2
    --160454674(+) CTGTGC/TTAGGT 4 -- ds50010--------
    rs1884399801,2
    C--160454691(+) GTTACA/GGTGAT 4 -- ds50010--------
    rs1917339881,2
    --160454789(+) TGATAG/TGATAA 4 -- ds50010--------
    rs121443591,2
    C--160454943(+) tcaagT/Cgattc 4 -- ut311Minor allele frequency- C:0.00NA 2
    rs1425639501,2
    --160455031(+) AAAGAC/TGGGGT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for SLAMF6 (160454820 - 160493052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLAMF6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872491CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606446    OMIM disorders: --

    20 diseases for SLAMF6:    About MalaCards
    griscelli syndrome    bare lymphocyte syndrome    leukocyte adhesion deficiency    cytomegalovirus infection
    human t-cell leukemia virus type 1    myelodysplastic syndromes    t-cell leukemia    influenza
    multiple myeloma    acute myeloid leukemia    myeloma    melanoma
    glioblastoma    myeloid leukemia    hepatitis b    leukemia
    systemic lupus erythematosus    lupus erythematosus    hepatocellular carcinoma    hepatitis


    SLAMF6 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SLAMF6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 58.6 2 11489943 (2)
    tumors 24.1 9 17395718 (1), 15187109 (1), 16709835 (1), 19404979 (1) (see all 8)
    virus infection 21.3 2 16709835 (1), 18524833 (1)
    melanoma 0 2 19259667 (1), 19491215 (1)

    Genetic Association Database (GAD): SLAMF6
    Human Genome Epidemiology (HuGE) Navigator: SLAMF6 (5 documents)

    Export disorders for SLAMF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLAMF6 gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with SLAMF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease. (PubMed id 11489943)1, 2, 3, 9 Bottino C....Moretta A. (2001)
    2. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. (PubMed id 17045824)1, 2, 9 Cao E.... Almo S.C. (2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PubMed id 12928397)1, 9 Tangye S.G.... van de Weerdt B.C.M. (2003)
    10. HIV-1 Vpu affects the anterograde transport and the gl ycosylation pattern of NTB-A. (PubMed id 23528733)1 Bolduan S....Schubert U. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114836 HGNC: 21392 AceView: SLAMF6 Ensembl:ENSG00000162739 euGenes: HUgn114836
    ECgene: SLAMF6 H-InvDB: SLAMF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLAMF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLAMF6 gene:
    Search GeneIP for patents involving SLAMF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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