Aliases for SLAMF6 Gene
External Ids for SLAMF6 Gene
Previous GeneCards Identifiers for SLAMF6 Gene
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
GeneCards Summary for SLAMF6 Gene
SLAMF6 (SLAM Family Member 6) is a Protein Coding gene. Diseases associated with SLAMF6 include bare lymphocyte syndrome, type i and griscelli syndrome. GO annotations related to this gene include receptor activity. An important paralog of this gene is CD84.
UniProtKB/Swiss-Prot for SLAMF6 Gene
Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.