SLAMF6 Gene

Aliases
for SLAMF6 gene

Previous GC identifers: GC01M157671 GC01M157267 GC01M158721 GC01M131811

Summaries
for SLAMF6 gene

Genomic Views
for SLAMF6 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004487.19  

SwitchGear Promoter luciferase reporter plasmid: SLAMF6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAMF6

SLAMF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160454:  view genomic region     (about GC identifiers)

Proteins
for SLAMF6 gene

1 PDB 3D structure from and Proteopedia for SLAMF6:

2IF7 (3D)    

Explore the universe of human proteins at neXtProt for SLAMF6: NX_Q96DU3

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SLAMF6 (NTB-A/SLAMF6)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): SLAMF6 OriGene Custom Protein Services for SLAMF6
	GenScript Custom Purified and Recombinant Proteins Services for SLAMF6
	Novus Biologicals SLAMF6 Proteins Novus Biologicals SLAMF6 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLAMF6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for SLAMF6 (NTB-A/SLAMF6)
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLAMF6
	GenScript Custom Superior Antibodies Services for SLAMF6
	Novus Biologicals SLAMF6 Antibodies
	Abcam antibodies for SLAMF6
	Uscn Antibodies for SLAMF6
	Search ThermoFisher Antibodies for SLAMF6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for SLAMF6 (NTB-A/SLAMF6)
	GenScript Custom Assay Services for SLAMF6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLAMF6

Protein Domains /
Families
for SLAMF6 gene

ProtoNet protein and cluster: Q96DU3

Function
for SLAMF6 gene

miRNA Products:		OriGene 3'-UTR Clone: SLAMF6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLAMF6
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAMF6 (see all 17):
		hsa-miR-485-5p hsa-miR-4307 hsa-miR-875-3p hsa-let-7d hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-28-5p
		SwitchGear 3'UTR luciferase reporter plasmid: SLAMF6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLAMF6 (see all 4) OriGene shRNA RFP: SLAMF6 OriGene siRNA: SLAMF6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLAMF6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLAMF6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLAMF6 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLAMF6 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): SLAMF6 (NM_052931)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAMF6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLAMF6
		Search LifeMap BioReagents cell lines for SLAMF6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF6

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Slamf6)

Pathways & Interactions
for SLAMF6 gene

Drugs & Compounds
for SLAMF6 gene

Transcripts
for SLAMF6 gene

Expression
for SLAMF6 gene

SLAMF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATGTATT

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	AdiposeBody Subcutaneous White Adipose			Adipose
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLAMF6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLAMF6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLAMF6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLAMF6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF6

Orthologs
for SLAMF6 gene

Paralogs
for SLAMF6 gene

Paralogs for SLAMF6 gene

SLAMF9²  SLAMF7²  CD84²  LY9²  

SLAMF6 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for SLAMF6
PGOHUM00000245049

Genomic Variants
for SLAMF6 gene

10/755 NCBI SNPs in SLAMF6 are shown (see all 755)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1809651251,2		--	160454339(+)	ATTATG/TTCAGT	4	--	ds5001		0	--	--	--	--
rs1850406761,2		--	160454351(+)	TTTCCC/TCATTC	4	--	ds5001		0	--	--	--	--
rs1901217761,2		--	160454370(+)	CAACCC/TCTTCC	4	--	ds5001		0	--	--	--	--
rs125660571,2	C,A,H,	--	160454460(+)	TCAGTG/AATAAT	4	--	ds5001		8		NA CSA WA EA	370
rs1831098331,2		--	160454594(+)	TATTTC/TATTTT	4	--	ds5001		0	--	--	--	--
rs1429955831,2		--	160454674(+)	CTGTGC/TTAGGT	4	--	ds5001		0	--	--	--	--
rs1884399801,2		--	160454691(+)	GTTACA/GGTGAT	4	--	ds5001		0	--	--	--	--
rs1917339881,2		--	160454789(+)	TGATAG/TGATAA	4	--	ds5001		0	--	--	--	--
rs121443591,2	C,	--	160454943(+)	TCAAGT/CGATTC	4	--	ut31		1		NA	2
rs1425639501,2		--	160455031(+)	AAAGAC/TGGGGT	4	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLAMF6 (160454820 - 160493052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SLAMF6: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLAMF6

DNA2.0 Custom Variant and Variant Library Synthesis for SLAMF6

Disorders / Diseases
for SLAMF6 gene

20/21 diseases for SLAMF6

4 Novoseek disease relationships for SLAMF6 gene    About this table

Publications
for SLAMF6 gene

PubMed articles for SLAMF6 gene, integrated from 9 sources (see all 93): (articles sorted by number of sources associating them with SLAMF6)

Utopia: connect your pdf to the dynamic world of online information

1. NTB-A, a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked Lymphoproliferative disease. (PubMed id 11489943)^{1, 2, 3, 9} Bottino C....Moretta A. (2001)
2. NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. (PubMed id 17045824)^{1, 2, 9} Cao E.... Almo S.C. (2006)
3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. (PubMed id 12928397)^{1, 9} Tangye S.G.... van de Weerdt B.C.M. (2003)
8. Increased expression of SLAM receptors SLAMF3 and SLAM F6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation. (PubMed id 22184727)¹ Chatterjee M....Tsokos G.C. (2012)
9. CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORgt recruitment to the IL17A promoter in human T lym phocytes. (PubMed id 22989874)¹ Chatterjee M....Tsokos G.C. (2012)
10. SLAMF6-driven co-stimulation of human peripheral T ce lls is defective in SLE T cells. (PubMed id 21231893)¹ Chatterjee M....Tsokos G.C. (2011)

External Searches for SLAMF6 gene

Genome Databases showing SLAMF6 gene

Other Databases showing SLAMF6 gene

Specialized Databases showing SLAMF6 gene

Products
for SLAMF6 gene