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Aliases for SLAMF1 Gene

Aliases for SLAMF1 Gene

  • Signaling Lymphocytic Activation Molecule Family Member 1 2 3
  • CDw150 3 4 6
  • SLAM 3 4 6
  • Signaling Lymphocytic Activation Molecule 2 3
  • CD150 3 6
  • IPO-3 3 4
  • CD150 Antigen 4

External Ids for SLAMF1 Gene

Previous Symbols for SLAMF1 Gene

  • SLAM

Summaries for SLAMF1 Gene

GeneCards Summary for SLAMF1 Gene

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include measles. Among its related pathways are Influenza A. GO annotations related to this gene include transmembrane signaling receptor activity and antigen binding.

UniProtKB/Swiss-Prot for SLAMF1 Gene

  • High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

Gene Wiki entry for SLAMF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF1 Gene

Genomics for SLAMF1 Gene

Genomic Location for SLAMF1 Gene

Start:
160,608,100 bp from pter
End:
160,647,311 bp from pter
Size:
39,212 bases
Orientation:
Minus strand

Genomic View for SLAMF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLAMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF1 Gene

Proteins for SLAMF1 Gene

  • Protein details for SLAMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13291-SLAF1_HUMAN
    Recommended name:
    Signaling lymphocytic activation molecule
    Protein Accession:
    Q13291
    Secondary Accessions:
    • Q5W172
    • Q9HBE8

    Protein attributes for SLAMF1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37231 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with SH2D1A, SH2D1B and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus H protein and acts as a receptor for this virus.

    Three dimensional structures from OCA and Proteopedia for SLAMF1 Gene

    Alternative splice isoforms for SLAMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF1 Gene

Proteomics data for SLAMF1 Gene at MOPED

Post-translational modifications for SLAMF1 Gene

  • Phosphorylated by FYN
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn53, Asn57, Asn102, Asn125, Asn150, Asn155, Asn189, and Asn217

Other Protein References for SLAMF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLAMF1 Gene

Domains for SLAMF1 Gene

Gene Families for SLAMF1 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for SLAMF1 Gene

UniProtKB/Swiss-Prot:

SLAF1_HUMAN
Domain:
  • The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues:
    • Q13291
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q13291
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q13291
genes like me logo Genes that share domains with SLAMF1: view

Function for SLAMF1 Gene

Molecular function for SLAMF1 Gene

UniProtKB/Swiss-Prot Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

Gene Ontology (GO) - Molecular Function for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 7617038
GO:0004872 receptor activity --
GO:0004888 transmembrane signaling receptor activity TAS 7617038
GO:0005515 protein binding IPI 10549287
genes like me logo Genes that share ontologies with SLAMF1: view

Phenotypes for SLAMF1 Gene

genes like me logo Genes that share phenotypes with SLAMF1: view

Animal Models for SLAMF1 Gene

MGI Knock Outs for SLAMF1:

miRNA for SLAMF1 Gene

miRTarBase miRNAs that target SLAMF1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLAMF1 Gene

Localization for SLAMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF1 Gene

Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAMF1 Gene COMPARTMENTS Subcellular localization image for SLAMF1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
GO:0016021 integral component of membrane IEA --
GO:0045335 phagocytic vesicle IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SLAMF1: view

Pathways for SLAMF1 Gene

SuperPathways for SLAMF1 Gene

Superpath Contained pathways
1 Influenza A
.34
genes like me logo Genes that share pathways with SLAMF1: view

Pathways by source for SLAMF1 Gene

1 KEGG pathway for SLAMF1 Gene

Gene Ontology (GO) - Biological Process for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7617038
GO:0008284 positive regulation of cell proliferation TAS 7617038
GO:0016032 viral process IEA --
GO:0031338 regulation of vesicle fusion IEA --
GO:0046649 lymphocyte activation IEA --
genes like me logo Genes that share ontologies with SLAMF1: view

Compounds for SLAMF1 Gene

(3) Novoseek inferred chemical compound relationships for SLAMF1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 41.4 16
phosphotyrosine 40.7 2
inositol 25.5 5
genes like me logo Genes that share compounds with SLAMF1: view

Transcripts for SLAMF1 Gene

Unigene Clusters for SLAMF1 Gene

Signaling lymphocytic activation molecule family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLAMF1 Gene

GeneLoc Exon Structure for
SLAMF1
ECgene alternative splicing isoforms for
SLAMF1

Expression for SLAMF1 Gene

mRNA expression in normal human tissues for SLAMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLAMF1 Gene

SOURCE GeneReport for Unigene cluster for SLAMF1 Gene Hs.523660

mRNA Expression by UniProt/SwissProt for SLAMF1 Gene

Q13291-SLAF1_HUMAN
Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation
genes like me logo Genes that share expressions with SLAMF1: view

Orthologs for SLAMF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAMF1 36
  • 99.8 (n)
  • 99.7 (a)
SLAMF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLAMF1 36
  • 78.64 (n)
  • 66.77 (a)
SLAMF1 37
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLAM 37
  • 65 (a)
OneToOne
SLAMF1 36
  • 78.41 (n)
  • 65.97 (a)
mouse
(Mus musculus)
Mammalia Slamf1 36
  • 74.83 (n)
  • 62.09 (a)
Slamf1 16
Slamf1 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLAMF1 37
  • 31 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slamf1 36
  • 72.94 (n)
  • 60 (a)
chicken
(Gallus gallus)
Aves SLAMF1 36
  • 47.12 (n)
  • 35.26 (a)
SLAMF1 37
  • 30 (a)
OneToOne
Species with no ortholog for SLAMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF1 Gene

ENSEMBL:
Gene Tree for SLAMF1 (if available)
TreeFam:
Gene Tree for SLAMF1 (if available)

Paralogs for SLAMF1 Gene

Selected SIMAP similar genes for SLAMF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLAMF1: view

No data available for Paralogs for SLAMF1 Gene

Variants for SLAMF1 Gene

Sequence variations from dbSNP and Humsavar for SLAMF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14413 -- 160,610,398(-) CTGAA(A/T)GCCAG utr-variant-3-prime, nc-transcript-variant
rs149160 -- 160,615,764(-) ggaca(C/G)tcatc intron-variant
rs151607 -- 160,615,916(-) CTTTA(A/G)GAGAA intron-variant
rs164274 -- 160,618,308(-) AGTGA(A/G)TTACC intron-variant
rs164275 -- 160,617,331(-) ttttt(G/T)gggta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF1 Gene

Variant ID Type Subtype PubMed ID
nsv872491 CNV Loss 21882294
nsv831703 CNV Gain 17160897
nsv831714 CNV Gain 17160897

Relevant External Links for SLAMF1 Gene

HapMap Linkage Disequilibrium report
SLAMF1

Disorders for SLAMF1 Gene

(1) MalaCards Diseases for SLAMF1 Gene

Search for SLAMF1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLAMF1 Gene

(14) Novoseek inferred disease relationships for SLAMF1 Gene

Disease -log(P) Hits PubMed IDs
lymphoproliferative syndrome 93.3 4
x-linked lymphoproliferative syndrome 91.9 3
measles 82.8 32
distemper canine 75.1 5
subacute sclerosing panencephalitis 68.4 2

Relevant External Links for SLAMF1

Genetic Association Database (GAD)
SLAMF1
Human Genome Epidemiology (HuGE) Navigator
SLAMF1
genes like me logo Genes that share disorders with SLAMF1: view

No data available for UniProtKB/Swiss-Prot for SLAMF1 Gene

Publications for SLAMF1 Gene

  1. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. (PMID: 9774102) Sayos J. … Terhorst C. (Nature 1998) 3 4 23
  2. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PMID: 10229804) Mikhalap S.V. … Sidorenko S.P. (J. Immunol. 1999) 3 4 23
  3. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. (PMID: 11689425) Morra M. … Terhorst C. (EMBO J. 2001) 3 4 23
  4. SAP couples Fyn to SLAM immune receptors. (PMID: 12545174) Chan B. … Eck M.J. (Nat. Cell Biol. 2003) 3 4 23
  5. A novel receptor involved in T-cell activation. (PMID: 7617038) Cocks B.G. … Aversa G. (Nature 1995) 2 3 4

Products for SLAMF1 Gene

Sources for SLAMF1 Gene

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