Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLAMF1 Gene

Aliases for SLAMF1 Gene

  • Signaling Lymphocytic Activation Molecule Family Member 1 2 3 5
  • Signaling Lymphocytic Activation Molecule 2 3
  • SLAM Family Member 1 3 4
  • CDw150 3 4
  • IPO-3 3 4
  • SLAM 3 4
  • CD150 Antigen 4
  • CD150 3

External Ids for SLAMF1 Gene

Previous HGNC Symbols for SLAMF1 Gene

  • SLAM

Previous GeneCards Identifiers for SLAMF1 Gene

  • GC01M157796
  • GC01M157392
  • GC01M158844
  • GC01M131936

Summaries for SLAMF1 Gene

GeneCards Summary for SLAMF1 Gene

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include Measles and Lymphoproliferative Syndrome, X-Linked, 1. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to this gene include receptor activity and antigen binding.

UniProtKB/Swiss-Prot for SLAMF1 Gene

  • Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in a allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity).

  • (Microbial infection) Acts as a receptor for measles virus; also including isoform 4 (PubMed:10972291, PubMed:25710480). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396).

Gene Wiki entry for SLAMF1 Gene

Additional gene information for SLAMF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF1 Gene

Genomics for SLAMF1 Gene

GeneHancer (GH) Regulatory Elements for SLAMF1 Gene

Promoters and enhancers for SLAMF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I160635 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.4 +5.5 5546 12.5 HDGF PKNOX1 SMAD1 RB1 BMI1 YBX1 BATF ATF7 ETV6 BCLAF1 SLAMF1 ENSG00000228863 RPL27AP2 SETP9 PPOX SLAMF6 CD48 CD84
GH01I160538 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.3 +105.9 105912 7.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT YY1 POLR2B ZNF766 CBX5 E2F8 CD84 SLAMF1 VANGL2 PPOX ENSG00000228863 SLAMF8 TSTD1 SLAMF6 CD48 DCAF8
GH01I160703 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -62.0 -62004 11.8 HDGF PKNOX1 SMAD1 KLF5 IRF4 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 CD48 SLAMF7 CD244 DEDD NCSTN ENSG00000228863 SLAMF1 LY9 LINC01133 ENSG00000256029
GH01I160573 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +70.6 70600 6.1 PKNOX1 RB1 ARNT BMI1 ZBTB40 ZNF766 EGR1 ATF7 FOS BCLAF1 CD84 SLAMF7 VANGL2 SLAMF6 SLAMF1 CD48 CD244 ATP1A4 LOC105371468
GH01I160794 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -150.7 -150653 6.8 HDGF PKNOX1 FOXA2 SMAD1 BMI1 BATF KLF5 IRF4 ZNF143 ATF7 LY9 SLAMF7 ENSG00000228863 ITLN1 SLAMF1 CD244 ATP1A4 SLAMF6 CD48 USF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLAMF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLAMF1 gene promoter:

Genomic Locations for SLAMF1 Gene

Genomic Locations for SLAMF1 Gene
chr1:160,608,100-160,647,537
(GRCh38/hg38)
Size:
39,438 bases
Orientation:
Minus strand
chr1:160,577,890-160,617,085
(GRCh37/hg19)

Genomic View for SLAMF1 Gene

Genes around SLAMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF1 Gene

Proteins for SLAMF1 Gene

  • Protein details for SLAMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13291-SLAF1_HUMAN
    Recommended name:
    Signaling lymphocytic activation molecule
    Protein Accession:
    Q13291
    Secondary Accessions:
    • Q5W172
    • Q9HBE8
    • W0HKK7

    Protein attributes for SLAMF1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37231 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:11313386, PubMed:11806999, PubMed:12458214). Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (PubMed:11313386, PubMed:12458214). Interacts with MAP4K1 (PubMed:20231852). Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:20818396).
    • (Microbial infection) Interacts with measles hemagglutinin protein.

    Three dimensional structures from OCA and Proteopedia for SLAMF1 Gene

    Alternative splice isoforms for SLAMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF1 Gene

Post-translational modifications for SLAMF1 Gene

  • Phosphorylated on tyrosine residues by FYN.
  • Glycosylation at isoforms=2, 353, isoforms=2, 357, isoforms=2, 3102, isoforms=2, 3125, posLast=150150, posLast=155155, isoforms=2, 3189, and posLast=217217

Antibody Products

No data available for DME Specific Peptides for SLAMF1 Gene

Domains & Families for SLAMF1 Gene

Gene Families for SLAMF1 Gene

Protein Domains for SLAMF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13291

UniProtKB/Swiss-Prot:

SLAF1_HUMAN :
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. For SLAMF1 a two-out-of-three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). SH2D1A binding is mediated by either three prongs (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-281 of ITSM 1 thus providing a positive feedback loop implicating SH2D1A-dependent recruitment of activating FYN. ITSM 2 needs to be phosphorylated on Tyr-327 for SH2D1A binding.
Domain:
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. For SLAMF1 a two-out-of-three-pronged mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). SH2D1A binding is mediated by either three prongs (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-281 of ITSM 1 thus providing a positive feedback loop implicating SH2D1A-dependent recruitment of activating FYN. ITSM 2 needs to be phosphorylated on Tyr-327 for SH2D1A binding.
genes like me logo Genes that share domains with SLAMF1: view

Function for SLAMF1 Gene

Molecular function for SLAMF1 Gene

UniProtKB/Swiss-Prot Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in a allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for measles virus; also including isoform 4 (PubMed:10972291, PubMed:25710480). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396).

Phenotypes From GWAS Catalog for SLAMF1 Gene

Gene Ontology (GO) - Molecular Function for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0003823 antigen binding TAS 7617038
GO:0004872 receptor activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS 7617038
GO:0005515 protein binding IPI 9774102
genes like me logo Genes that share ontologies with SLAMF1: view
genes like me logo Genes that share phenotypes with SLAMF1: view

Animal Models for SLAMF1 Gene

MGI Knock Outs for SLAMF1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLAMF1 Gene

Localization for SLAMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF1 Gene

Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). {ECO:0000269 PubMed:11806999}.
Isoform 3: Secreted.
Isoform 4: Cell membrane. Note=Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. {ECO:0000269 PubMed:25710480}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAMF1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLAMF1 Gene

Pathways & Interactions for SLAMF1 Gene

genes like me logo Genes that share pathways with SLAMF1: view

SIGNOR curated interactions for SLAMF1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002277 myeloid dendritic cell activation involved in immune response IDA 16317102
GO:0002376 immune system process IEA --
GO:0006909 phagocytosis IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SLAMF1: view

Drugs & Compounds for SLAMF1 Gene

(2) Drugs for SLAMF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLAMF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLAMF1: view

Transcripts for SLAMF1 Gene

Unigene Clusters for SLAMF1 Gene

Signaling lymphocytic activation molecule family member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLAMF1 Gene

GeneLoc Exon Structure for
SLAMF1
ECgene alternative splicing isoforms for
SLAMF1

Expression for SLAMF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLAMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLAMF1 Gene

This gene is overexpressed in Plasma (38.6), Peripheral blood mononuclear cells (9.2), CD8 Tcells (8.4), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLAMF1 Gene



Protein tissue co-expression partners for SLAMF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLAMF1 Gene:

SLAMF1

SOURCE GeneReport for Unigene cluster for SLAMF1 Gene:

Hs.523660

mRNA Expression by UniProt/SwissProt for SLAMF1 Gene:

Q13291-SLAF1_HUMAN
Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1, isoform 3 and a cytoplasmic isoform (PubMed:9091591). Isoform 4 is expressed in B-cells, primary T-cells, dendritic cells and macrophages. Isoform 4 is expressed in tumors of the central nervous system (PubMed:25710480).

Evidence on tissue expression from TISSUES for SLAMF1 Gene

  • Blood(4.5)
  • Lymph node(2.7)
  • Spleen(2.5)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SLAMF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAMF1 Gene

Orthologs for SLAMF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAMF1 33 34
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia SLAMF1 33 34
  • 78.64 (n)
dog
(Canis familiaris)
Mammalia SLAMF1 33
  • 78.41 (n)
SLAM 34
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slamf1 33 16 34
  • 74.83 (n)
rat
(Rattus norvegicus)
Mammalia Slamf1 33
  • 72.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLAMF1 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLAMF1 33 34
  • 47.12 (n)
Species where no ortholog for SLAMF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF1 Gene

ENSEMBL:
Gene Tree for SLAMF1 (if available)
TreeFam:
Gene Tree for SLAMF1 (if available)

Paralogs for SLAMF1 Gene

(1) SIMAP similar genes for SLAMF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLAMF1: view

No data available for Paralogs for SLAMF1 Gene

Variants for SLAMF1 Gene

Sequence variations from dbSNP and Humsavar for SLAMF1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
VAR_035524 A breast cancer sample p.Leu81Phe
rs1000054579 -- 160,645,564(-) C/T intron_variant
rs1000280750 -- 160,640,291(-) G/C intron_variant
rs1000306251 -- 160,635,753(-) G/C/T intron_variant
rs1000322931 -- 160,610,175(-) T/A 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF1 Gene

Variant ID Type Subtype PubMed ID
nsv831703 CNV gain 17160897
nsv831714 CNV gain 17160897

Variation tolerance for SLAMF1 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.99; 68.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLAMF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLAMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF1 Gene

Disorders for SLAMF1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLAMF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
measles
  • morbilli
lymphoproliferative syndrome, x-linked, 1
  • xlp1
lymphoproliferative syndrome
  • lymphoproliferative disorder
immune deficiency disease
  • primary immunodeficiency disease
systemic lupus erythematosus
  • sle
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLAMF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLAMF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLAMF1 Gene

Publications for SLAMF1 Gene

  1. SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells. (PMID: 16317102) Réthi B … Lányi A (Blood 2006) 3 4 22 58
  2. Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients. (PMID: 12629654) Ferrand V … Yin L (Journal of medical virology 2003) 3 4 44 58
  3. Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. (PMID: 12458214) Li C … Li SS (The Journal of biological chemistry 2003) 3 4 22 58
  4. SAP couples Fyn to SLAM immune receptors. (PMID: 12545174) Chan B … Eck MJ (Nature cell biology 2003) 3 4 22 58
  5. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. (PMID: 11806999) Howie D … Terhorst C (Blood 2002) 3 4 22 58

Products for SLAMF1 Gene

Sources for SLAMF1 Gene

Content
Loading form....