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Aliases for SLAMF1 Gene

Aliases for SLAMF1 Gene

  • Signaling Lymphocytic Activation Molecule Family Member 1 2 3
  • CDw150 3 4
  • IPO-3 3 4
  • SLAM 3 4
  • Signaling Lymphocytic Activation Molecule 2
  • CD150 Antigen 4
  • CD150 3

External Ids for SLAMF1 Gene

Previous HGNC Symbols for SLAMF1 Gene

  • SLAM

Previous GeneCards Identifiers for SLAMF1 Gene

  • GC01M157796
  • GC01M157392
  • GC01M158844
  • GC01M131936

Summaries for SLAMF1 Gene

GeneCards Summary for SLAMF1 Gene

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include measles and subacute sclerosing panencephalitis. Among its related pathways are Influenza A. GO annotations related to this gene include receptor activity and antigen binding.

UniProtKB/Swiss-Prot for SLAMF1 Gene

  • High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

  • (Microbial infection) Acts as a receptor for measles virus.

Gene Wiki entry for SLAMF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF1 Gene

Genomics for SLAMF1 Gene

Genomic Location for SLAMF1 Gene

Chromosome:
1
Start:
160,608,100 bp from pter
End:
160,647,537 bp from pter
Size:
39,438 bases
Orientation:
Minus strand

Genomic View for SLAMF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLAMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF1 Gene

Proteins for SLAMF1 Gene

  • Protein details for SLAMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13291-SLAF1_HUMAN
    Recommended name:
    Signaling lymphocytic activation molecule
    Protein Accession:
    Q13291
    Secondary Accessions:
    • Q5W172
    • Q9HBE8

    Protein attributes for SLAMF1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37231 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with SH2D1A, SH2D1B and with PTPN11. Interacts with INPP5D/SHIP1. (Microbial infection) Interacts with measles hemagglutinin protein (PubMed:10972291).

    Three dimensional structures from OCA and Proteopedia for SLAMF1 Gene

    Alternative splice isoforms for SLAMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF1 Gene

Proteomics data for SLAMF1 Gene at MOPED

Post-translational modifications for SLAMF1 Gene

  • Phosphorylated by FYN
  • Glycosylation at Asn 53, Asn 57, Asn 102, Asn 125, Asn 150, Asn 155, Asn 189, and Asn 217
  • Modification sites at PhosphoSitePlus

Other Protein References for SLAMF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for SLAMF1

No data available for DME Specific Peptides for SLAMF1 Gene

Domains & Families for SLAMF1 Gene

Gene Families for SLAMF1 Gene

Protein Domains for SLAMF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q13291

UniProtKB/Swiss-Prot:

SLAF1_HUMAN :
  • The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues
Domain:
  • The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SLAMF1: view

Function for SLAMF1 Gene

Molecular function for SLAMF1 Gene

UniProtKB/Swiss-Prot Function:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for measles virus.

Gene Ontology (GO) - Molecular Function for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0003823 antigen binding TAS 7617038
GO:0004872 receptor activity --
GO:0004888 transmembrane signaling receptor activity TAS 7617038
GO:0005515 protein binding IPI 9774102
genes like me logo Genes that share ontologies with SLAMF1: view
genes like me logo Genes that share phenotypes with SLAMF1: view

Animal Models for SLAMF1 Gene

MGI Knock Outs for SLAMF1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLAMF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLAMF1 Gene

Localization for SLAMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF1 Gene

Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAMF1 Gene COMPARTMENTS Subcellular localization image for SLAMF1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface --
GO:0016021 integral component of membrane IEA --
GO:0045335 phagocytic vesicle IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SLAMF1: view

Pathways & Interactions for SLAMF1 Gene

SuperPathways for SLAMF1 Gene

Superpath Contained pathways
1 Influenza A
.35
genes like me logo Genes that share pathways with SLAMF1: view

Pathways by source for SLAMF1 Gene

1 KEGG pathway for SLAMF1 Gene

SIGNOR curated interactions for SLAMF1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 7617038
GO:0008284 positive regulation of cell proliferation TAS 7617038
GO:0016032 viral process --
GO:0031338 regulation of vesicle fusion IEA --
GO:0046649 lymphocyte activation IEA --
genes like me logo Genes that share ontologies with SLAMF1: view

Drugs & Compounds for SLAMF1 Gene

(2) Drugs for SLAMF1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Inositol Nutra 65
tyrosine Nutra 547

(1) Additional Compounds for SLAMF1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphotyrosine
genes like me logo Genes that share compounds with SLAMF1: view

Transcripts for SLAMF1 Gene

Unigene Clusters for SLAMF1 Gene

Signaling lymphocytic activation molecule family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLAMF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLAMF1 Gene

GeneLoc Exon Structure for
SLAMF1
ECgene alternative splicing isoforms for
SLAMF1

Expression for SLAMF1 Gene

mRNA expression in normal human tissues for SLAMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLAMF1 Gene

This gene is overexpressed in Plasma (38.6), Peripheral blood mononuclear cells (9.2), CD8 Tcells (8.4), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLAMF1 Gene



SOURCE GeneReport for Unigene cluster for SLAMF1 Gene Hs.523660

mRNA Expression by UniProt/SwissProt for SLAMF1 Gene

Q13291-SLAF1_HUMAN
Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation
genes like me logo Genes that share expression patterns with SLAMF1: view

Protein tissue co-expression partners for SLAMF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLAMF1 Gene

Orthologs for SLAMF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAMF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLAMF1 35
  • 78.64 (n)
  • 66.77 (a)
SLAMF1 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLAMF1 35
  • 78.41 (n)
  • 65.97 (a)
SLAM 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slamf1 35
  • 74.83 (n)
  • 62.09 (a)
Slamf1 16
Slamf1 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLAMF1 35
  • 99.8 (n)
  • 99.7 (a)
SLAMF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slamf1 35
  • 72.94 (n)
  • 60 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SLAMF1 36
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLAMF1 35
  • 47.12 (n)
  • 35.26 (a)
SLAMF1 36
  • 30 (a)
OneToOne
Species with no ortholog for SLAMF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF1 Gene

ENSEMBL:
Gene Tree for SLAMF1 (if available)
TreeFam:
Gene Tree for SLAMF1 (if available)

Paralogs for SLAMF1 Gene

(1) SIMAP similar genes for SLAMF1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLAMF1: view

No data available for Paralogs for SLAMF1 Gene

Variants for SLAMF1 Gene

Sequence variations from dbSNP and Humsavar for SLAMF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1726 -- 160,608,214(-) GTTAC(A/T)GCGGG utr-variant-3-prime
rs14413 -- 160,610,398(-) CTGAA(A/T)GCCAG utr-variant-3-prime, nc-transcript-variant
rs149160 -- 160,615,764(-) ggaca(C/G)tcatc intron-variant
rs151607 -- 160,615,916(-) CTTTA(A/G)GAGAA intron-variant
rs164274 -- 160,618,308(-) AGTGA(A/G)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF1 Gene

Variant ID Type Subtype PubMed ID
nsv872491 CNV Loss 21882294
nsv831703 CNV Gain 17160897
nsv831714 CNV Gain 17160897

Variation tolerance for SLAMF1 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.99; 68.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLAMF1 Gene

HapMap Linkage Disequilibrium report
SLAMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF1 Gene

Disorders for SLAMF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLAMF1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
measles
  • morbilli
subacute sclerosing panencephalitis
  • subacute sclerosing leukoencephalopathy
lymphoproliferative syndrome, x-linked, 1
  • lymphoproliferative syndrome, x-linked
- elite association

Relevant External Links for SLAMF1

Genetic Association Database (GAD)
SLAMF1
Human Genome Epidemiology (HuGE) Navigator
SLAMF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLAMF1
genes like me logo Genes that share disorders with SLAMF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLAMF1 Gene

Publications for SLAMF1 Gene

  1. Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). (PMID: 20042501) Ferreira C.S. … Cattaneo R. (J. Virol. 2010) 23 67
  2. Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. (PMID: 20071568) Leonard V.H. … Cattaneo R. (J. Virol. 2010) 23 67
  3. Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. (PMID: 20153220) Cannons J.L. … Schwartzberg P.L. (Immunity 2010) 23 67
  4. Measles virus-induced immunosuppression in SLAM knock-in mice. (PMID: 20200244) Koga R. … Yanagi Y. (J. Virol. 2010) 23 67
  5. Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells. (PMID: 19124732) Good K.L. … Tangye S.G. (J. Immunol. 2009) 23 67

Products for SLAMF1 Gene

Sources for SLAMF1 Gene

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