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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLAMF1 Gene

protein-coding   GIFtS: 64
GCID: GC01M160577

Signaling Lymphocytic Activation Molecule Family Member...

(Previous name: signaling lymphocytic activation molecule)
(Previous symbol: SLAM)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signaling Lymphocytic Activation Molecule Family Member 11 2     IPO-32 3
SLAM1 2 3 5     CD1502 5
Signaling Lymphocytic Activation Molecule1 2     CD150 Antigen3
CDw1502 3     CDW1505

External Ids:    HGNC: 109031   Entrez Gene: 65042   Ensembl: ENSG000001170907   OMIM: 6034925   UniProtKB: Q132913   

Export aliases for SLAMF1 gene to outside databases

Previous GC identifers: GC01M157796 GC01M157392 GC01M158844 GC01M131936


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLAMF1 Gene: 
SLAMF1 (signaling lymphocytic activation molecule family member 1) is a protein-coding gene. Diseases associated with SLAMF1 include dysgammaglobulinemia, and subacute sclerosing panencephalitis, and among its related super-pathways are Influenza A. GO annotations related to this gene include antigen binding and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced
signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are
likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which
protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

Gene Wiki entry for SLAMF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLAMF1 gene promoter:
         AP-2alpha isoform 3   ATF-2   MyoD   AP-2alpha isoform 2   CRE-BP1   AREB6   IRF-7A   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLAMF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLAMF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAMF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

SLAMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAMF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160577:  view genomic region     (about GC identifiers)

Start:
160,577,890 bp from pter      End:
160,617,085 bp from pter
Size:
39,196 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291 (See protein sequence)
Recommended Name: Signaling lymphocytic activation molecule precursor  
Size: 335 amino acids; 37231 Da
Subunit: Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to
Measles virus H protein and acts as a receptor for this virus
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells
and T-cells
6/9 PDB 3D structures from and Proteopedia for SLAMF1 (see all 9):
1D4T (3D)        1D4W (3D)        1KA6 (3D)        1KA7 (3D)        1M27 (3D)        2DZF (3D)    
Secondary accessions: Q5W172
Alternative splicing: 3 isoforms:  Q13291-1   Q13291-2   Q13291-3   

Explore the universe of human proteins at neXtProt for SLAMF1: NX_Q13291

Explore proteomics data for SLAMF1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by FYN
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13291

  • SLAMF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLAMF1 Protein Expression
    REFSEQ proteins: NP_003028.1  
    ENSEMBL proteins: 
     ENSP00000306190   ENSP00000235739   ENSP00000438406   ENSP00000347333  

    Human Recombinant Protein Products for SLAMF1: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
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    Sino Biological Recombinant Protein for SLAMF1
    Sino Biological Cell Lysate for SLAMF1 
    ProSpec Recombinant Protein for SLAMF1
    Cloud-Clone Corp. Proteins for SLAMF1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral to membrane IEA--

    SLAMF1 for ontologies           About GeneDecksing



    SLAMF1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SLAMF1 

    Assay Products for SLAMF1: 
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    GenScript Custom Assay Services for SLAMF1
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    Cloud-Clone Corp. ELISAs for SLAMF1 
    Cloud-Clone Corp. CLIAs for SLAMF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR015631 SLAM_fam_rcpts
     IPR010407 Sig_lymph_act_molc_N

    Graphical View of Domain Structure for InterPro Entry Q13291

    ProtoNet protein and cluster: Q13291

    UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Domain: The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be
    phosphorylated on tyrosine residues
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SLAMF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAF1_HUMAN, Q13291
    Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced
    signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are
    likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which
    protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS7617038
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity TAS7617038
    GO:0005515protein binding IPI10549287
         
    SLAMF1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slamf1):
     cellular  hematopoietic system  immune system 

    SLAMF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLAMF1: Slamf1tm1Cpt Slamf1tm1Vei

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLAMF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLAMF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLAMF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLAMF1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSLAMF1 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of SLAMF1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLAMF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Measles0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for SLAMF1):
        Measles


    SLAMF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLAMF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for SLAMF1 (Q132911, 2, 3 ENSP000003061904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1AO608802, 3, ENSP000003601814MINT-8031819 MINT-8031894 MINT-8031924 MINT-59435 MINT-8031803 MINT-8031939 MINT-8031784 MINT-8031668 MINT-8031709 MINT-8031694 MINT-8031879 MINT-8031909 MINT-8027270 I2D: score=8 STRING: ENSP00000360181
    PTPN11Q061242, 3, ENSP000003409444MINT-8031754 MINT-8031769 I2D: score=5 STRING: ENSP00000340944
    INPP5DQ928352, 3, ENSP000003525754MINT-8031724 MINT-8031739 I2D: score=2 STRING: ENSP00000352575
    SH2D1BO147962, 3, ENSP000003569064MINT-8031683 I2D: score=4 STRING: ENSP00000356906
    FYNP062413, ENSP000003576564I2D: score=4 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation TAS7617038
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0046649lymphocyte activation IEA--

    SLAMF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLAMF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLAMF1 (SLAF1)

    3 Novoseek inferred chemical compound relationships for SLAMF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 41.4 18 11313386 (4), 11806999 (3), 11689425 (2), 10229804 (2) (see all 9)
    phosphotyrosine 40.7 2 11689425 (1), 10607564 (1)
    inositol 25.5 5 11313386 (2), 15315965 (2), 10229804 (1)

    Search CenterWatch for drugs/clinical trials and news about SLAMF1 / SLAF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLAMF1 gene: 
    NM_003037.2  

    Unigene Cluster for SLAMF1:

    Signaling lymphocytic activation molecule family member 1
    Hs.523660  [show with all ESTs]
    Unigene Representative Sequence: NM_003037
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302035(uc001fwl.4 uc010pjk.2 uc010pjl.2 uc010pjm.2)
    ENST00000497223 ENST00000494463 ENST00000235739 ENST00000538290 ENST00000355199(uc001fwm.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAMF1:
    hsa-miR-3163 hsa-miR-3659 hsa-miR-2114 hsa-miR-759 hsa-miR-3190 hsa-miR-518a-5p hsa-miR-323-5p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK304237.1 AK311666.1 AK314244.1 AY040554.1 BC012602.1 BC110349.1 BC132792.1 BC144498.1 
    BC144499.1 BC144500.1 U33017.1 

    4 DOTS entries:

    DT.210509  DT.100738081  DT.100747441  DT.102837084 

    24/44 AceView cDNA sequences (see all 44):

    AY040554 BF507546 CR590430 BC012602 AI224384 AW340092 BX348938 AA865341 
    BI911191 AW593108 BX482030 BX329073 CB989224 BQ028153 AA769421 AA825199 
    BC067847 BU616725 BM676376 AA458996 AW469535 CB961154 NM_003037 BM713255 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                          -                             -                           
    SP2:                          -                 -     -     -                           
    SP3:                          -                                                         
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for SLAMF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLAMF1 expression in normal human tissues (normalized intensities)      SLAMF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAACCTGCA
    SLAMF1 Expression
    About this image


    SLAMF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 11 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             b cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
             Liver Lobule
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac

    See SLAMF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLAMF1

    SOURCE GeneReport for Unigene cluster: Hs.523660

    UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature
    thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLAMF1 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slamf11 , 5 signaling lymphocytic activation molecule family member more1, 5 74.83(n)1
    62.09(a)1
      1 (79.54 cM)5
    272181  NM_013730.41  NP_038758.21 
     1717671275 
    chicken
    (Gallus gallus)
    Aves SLAMF11 signaling lymphocytic activation molecule family member more 45.93(n)
    34.29(a)
      425300  XM_423077.3  XP_423077.3 


    ENSEMBL Gene Tree for SLAMF1 (if available)
    TreeFam Gene Tree for SLAMF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLAMF1 gene
    1 SIMAP similar gene for SLAMF1 using alignment to 3 protein entries:     SLAF1_HUMAN (see all proteins):
    SLAM

    SLAMF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/932 SNPs in SLAMF1 are shown (see all 932)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355244
    A breast cancer sample4--see VAR_0355242 L F mis40--------
    rs75286071,2
    C,F,A,H--160579489(+) TTCAAA/GGATTT 1 -- int15Minor allele frequency- G:0.01NS EA NA 532
    rs1872633721,2
    --160579509(+) AGACCA/GAAATA 1 -- int10--------
    rs75195131,2
    C,H--160579799(+) TGCTAC/TGTTTT 1 -- int1 ese35Minor allele frequency- T:0.00NS EA NA 532
    rs37965031,2
    C,H--160579806(+) TTTTTC/ATTTAA 1 -- int1 ese39Minor allele frequency- A:0.00MN NS EA 820
    rs92828491,2
    C,F--160579815(-) CATTCA/CGTTTT 1 -- int15Minor allele frequency- C:0.01MN 404
    rs1926005601,2
    --160579943(+) CAAATA/GAAATA 1 -- ut310--------
    rs10612171,2
    C,F,A,H--160580015(-) GAGGCT/CGAAGG 1 -- ut31 ese336Minor allele frequency- C:0.48EA MN NA NS WA CSA 3457
    rs92828501,2
    F--160580045(-) CAGTTT/-CTCTC 1 -- ut31 trp35Minor allele frequency- -:0.01MN 400
    rs92828511,2
    C,F--160580065(-) CTGATC/GAAGCC 1 -- ut315Minor allele frequency- G:0.01MN 396

    HapMap Linkage Disequilibrium report for SLAMF1 (160577890 - 160617085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLAMF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872491CNV Loss21882294
    nsv831714CNV Gain17160897
    nsv831703CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603492    OMIM disorders: --

    20/24 diseases for SLAMF1 (see all 24):    About MalaCards
    dysgammaglobulinemia    subacute sclerosing panencephalitis    measles    stomatitis
    hemophagocytic lymphohistiocytosis    protein s deficiency    allergic rhinitis    conjunctivitis
    multiple sclerosis    rhinitis    chronic lymphocytic leukemia    blindness
    crohn's disease    systemic lupus erythematosus    lupus erythematosus    hodgkin's lymphoma
    hepatitis b    ovarian cancer    tuberculosis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for SLAMF1:
    Measles

    SLAMF1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/14 Novoseek inferred disease relationships for SLAMF1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 93.3 4 14523387 (1), 12766168 (1), 11313386 (1), 10229804 (1)
    x-linked lymphoproliferative syndrome 91.9 3 11313386 (1), 12458214 (1), 11099315 (1)
    measles 82.8 50 16889684 (2), 11950898 (2), 20071568 (2), 12270725 (2) (see all 23)
    distemper canine 75.1 6 12941904 (2), 16963735 (1), 16495625 (1), 12917459 (1)
    subacute sclerosing panencephalitis 68.4 2 11950898 (2)
    ebv infections 61.7 2 9774102 (1), 12766168 (1)
    vesicular stomatitis 55 2 11160657 (1)
    immunodeficiency 41.3 1 12766168 (1)
    virus infection 24.3 6 11376478 (1), 11244050 (1), 20042501 (1), 17135325 (1)
    hodgkin disease 15.3 5 15315965 (2), 15812353 (2)

    Genetic Association Database (GAD): SLAMF1
    Human Genome Epidemiology (HuGE) Navigator: SLAMF1 (7 documents)

    Export disorders for SLAMF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLAMF1 gene, integrated from 9 sources (see all 151):
    (articles sorted by number of sources associating them with SLAMF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel receptor involved in T-cell activation. (PubMed id 7617038)1, 2, 3 Cocks B.G....Aversa G. (1995)
    2. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PubMed id 10229804)1, 2, 9 Mikhalap S.V....Sidorenko S.P. (1999)
    3. SAP couples Fyn to SLAM immune receptors. (PubMed id 12545174)1, 2, 9 Chan B....Eck M.J. (2003)
    4. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. (PubMed id 9774102)1, 2, 9 Sayos J.... Terhorst C. (1998)
    5. Genome-wide association study of treatment refractory schizophrenia in Han Chinese. (PubMed id 22479419)1, 4 Liou Y.J....Wu J.Y. (2012)
    6. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Detection and functional evaluation of -262A/T and -1 88A/G polymorphisms of SLAM gene in patients with systemic lupus erythematosus. (PubMed id 20810499)1, 4 You Y....Hao F. (2010)
    9. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6504 HGNC: 10903 AceView: SLAMF1 Ensembl:ENSG00000117090 euGenes: HUgn6504
    ECgene: SLAMF1 Kegg: 6504 H-InvDB: SLAMF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLAMF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLAMF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLAMF1 gene:
    Search GeneIP for patents involving SLAMF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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