Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLAMF1 Gene

protein-coding   GIFtS: 65
GCID: GC01M160577

Signaling Lymphocytic Activation Molecule Family Member...

(Previous name: signaling lymphocytic activation molecule)
(Previous symbol: SLAM)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Signaling Lymphocytic Activation Molecule Family Member 11 2     IPO-32 3
SLAM1 2 3 5     CD1502 5
Signaling Lymphocytic Activation Molecule1 2     CD150 Antigen3
CDw1502 3     CDW1505

External Ids:    HGNC: 109031   Entrez Gene: 65042   Ensembl: ENSG000001170907   OMIM: 6034925   UniProtKB: Q132913   

Export aliases for SLAMF1 gene to outside databases

Previous GC identifers: GC01M157796 GC01M157392 GC01M158844 GC01M131936


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLAMF1 Gene:
SLAMF1 (signaling lymphocytic activation molecule family member 1) is a protein-coding gene. Diseases associated with SLAMF1 include dysgammaglobulinemia, and measles. GO annotations related to this gene include antigen binding and transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced
signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are
likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which
protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

Gene Wiki entry for SLAMF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLAMF1 gene promoter:
         AP-2alpha isoform 3   ATF-2   MyoD   AP-2alpha isoform 2   CRE-BP1   AREB6   IRF-7A   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLAMF1 promoter sequence
   Search Chromatin IP Primers for SLAMF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLAMF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

SLAMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAMF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160577:  view genomic region     (about GC identifiers)

Start:
160,577,890 bp from pter      End:
160,617,085 bp from pter
Size:
39,196 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291 (See protein sequence)
Recommended Name: Signaling lymphocytic activation molecule precursor  
Size: 335 amino acids; 37231 Da
Subunit: Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to
Measles virus H protein and acts as a receptor for this virus
Selected PDB 3D structures from and Proteopedia for SLAMF1 (see all 9):
1D4T (3D)        1D4W (3D)        1KA6 (3D)        1KA7 (3D)        1M27 (3D)        2DZF (3D)    
Secondary accessions: Q5W172
Alternative splicing: 3 isoforms:  Q13291-1   Q13291-2   Q13291-3   

Explore the universe of human proteins at neXtProt for SLAMF1: NX_Q13291

Explore proteomics data for SLAMF1 at MOPED

Post-translational modifications: 

  • Phosphorylated by FYN1
  • Glycosylation2 at Asn53, Asn57, Asn102, Asn125, Asn150, Asn155, Asn189, Asn217
  • Modification sites at PhosphoSitePlus

  • See SLAMF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003028.1  
    ENSEMBL proteins: 
     ENSP00000306190   ENSP00000235739   ENSP00000438406   ENSP00000347333  

    SLAMF1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SLAMF1 (SLAM/CD150)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLAMF1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLAMF1
    GenScript Custom Purified and Recombinant Proteins Services for SLAMF1
    Novus Biologicals SLAMF1 Proteins
    Novus Biologicals SLAMF1 Lysate
    Sino Biological Recombinant Protein for SLAMF1
    Sino Biological Cell Lysate for SLAMF1
    ProSpec Recombinant Protein for SLAMF1
    Cloud-Clone Corp. Proteins for SLAMF1

    SLAMF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLAMF1
    R&D Systems Antibodies for SLAMF1 (SLAM/CD150)
    OriGene Antibodies for SLAMF1
    OriGene Custom Antibody Services for SLAMF1
    Novus Biologicals SLAMF1 Antibodies
    Abcam antibodies for SLAMF1
    Cloud-Clone Corp. Antibodies for SLAMF1
    ThermoFisher Antibodies for SLAMF1
    LSBio Antibodies in human, mouse, rat for SLAMF1

    SLAMF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLAMF1
    R&D Systems ELISAs for SLAMF1 (SLAM/CD150)         (see all)
    GenScript Custom Assay Services for SLAMF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLAMF1
    Cloud-Clone Corp. CLIAs for SLAMF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR015631 SLAM_fam_rcpts
     IPR010407 Sig_lymph_act_molc_N
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13291

    ProtoNet protein and cluster: Q13291

    UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Domain: The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be
    phosphorylated on tyrosine residues
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SLAMF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAF1_HUMAN, Q13291
    Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced
    signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are
    likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which
    protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS7617038
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity TAS7617038
    GO:0005515protein binding IPI10549287
         
    SLAMF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slamf1):
     hematopoietic system  immune system 

    SLAMF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLAMF1: Slamf1tm1Cpt Slamf1tm1Vei

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLAMF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLAMF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLAMF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLAMF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLAMF1:
    hsa-mir-26b-5p (MIRT030083)

    Block miRNA regulation of human, mouse, rat SLAMF1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SLAMF1:
    hsa-miR-3163 hsa-miR-3659 hsa-miR-2114 hsa-miR-759 hsa-miR-3190 hsa-miR-518a-5p hsa-miR-323-5p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLAMF1
    Predesigned siRNA for gene silencing in human, mouse, rat SLAMF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLAMF1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLAMF1 (see all 6)
    OriGene ORF clones in mouse, rat for SLAMF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLAMF1 (NM_003037)
    Sino Biological Human cDNA Clone for SLAMF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLAMF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLAMF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SLAF1_HUMAN, Q13291: Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells
    and T-cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    SLAMF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLAMF1 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Measles0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for SLAMF1):
        Measles


    SLAMF1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLAMF1
    Interactions:

        GeneGlobe Interaction Network for SLAMF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for SLAMF1 (Q132911, 2, 3 ENSP000003061904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1AO608801, 2, 3, ENSP000003601814EBI-4315002,EBI-6983382 MINT-8031819 MINT-8031894 MINT-8031924 MINT-59435 MINT-8031803 MINT-8031939 MINT-8031784 MINT-8031668 MINT-8031709 MINT-8031694 MINT-8031879 MINT-8031909 MINT-8027270 I2D: score=8 STRING: ENSP00000360181
    PTPN11Q061242, 3, ENSP000003409444MINT-8031754 MINT-8031769 I2D: score=5 STRING: ENSP00000340944
    INPP5DQ928352, 3, ENSP000003525754MINT-8031724 MINT-8031739 I2D: score=2 STRING: ENSP00000352575
    SH2D1BO147962, 3, ENSP000003569064MINT-8031683 I2D: score=4 STRING: ENSP00000356906
    FYNP062413, ENSP000003576564I2D: score=4 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS7617038
    GO:0008284positive regulation of cell proliferation TAS7617038
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0046649lymphocyte activation IEA--

    SLAMF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLAMF1 (SLAF1)

    3 Novoseek inferred chemical compound relationships for SLAMF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 41.4 18 11313386 (4), 11806999 (3), 11689425 (2), 10229804 (2) (see all 9)
    phosphotyrosine 40.7 2 11689425 (1), 10607564 (1)
    inositol 25.5 5 11313386 (2), 15315965 (2), 10229804 (1)



    SLAMF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLAMF1 gene: 
    NM_003037.3  

    Unigene Cluster for SLAMF1:

    Signaling lymphocytic activation molecule family member 1
    Hs.523660  [show with all ESTs]
    Unigene Representative Sequence: NM_003037
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302035(uc001fwl.4 uc010pjk.2 uc010pjl.2 uc010pjm.2)
    ENST00000494463 ENST00000235739 ENST00000538290 ENST00000355199(uc001fwm.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLAMF1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SLAMF1:
    hsa-miR-3163 hsa-miR-3659 hsa-miR-2114 hsa-miR-759 hsa-miR-3190 hsa-miR-518a-5p hsa-miR-323-5p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLAMF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLAMF1
    Predesigned siRNA for gene silencing in human, mouse, rat SLAMF1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLAMF1 (see all 6)
    OriGene ORF clones in mouse, rat for SLAMF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLAMF1 (NM_003037)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLAMF1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLAMF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLAMF1
      QuantiTect SYBR Green Assays in human, mouse, rat SLAMF1
      QuantiFast Probe-based Assays in human, mouse, rat SLAMF1

    Additional mRNA sequence: 

    AK304237.1 AK311666.1 AK314244.1 AY040554.1 BC012602.1 BC110349.1 BC132792.1 BC144498.1 
    BC144499.1 BC144500.1 U33017.1 

    4 DOTS entries:

    DT.210509  DT.100738081  DT.100747441  DT.102837084 

    Selected AceView cDNA sequences (see all 44):

    BF507546 AY040554 CR590430 BC067847 BM713255 AA825199 BX329073 BU616725 
    BI911191 AA769421 BX482030 AW340092 AA458996 AW469535 BM676376 CB961154 
    AI224384 BX348938 AW593108 BQ028153 NM_003037 BP344458 BC012602 U33017 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                          -                             -                           
    SP2:                          -                 -     -     -                           
    SP3:                          -                                                         
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for SLAMF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLAMF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAACCTGCA
    SLAMF1 Expression
    About this image


    SLAMF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 11 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             b cells   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
             Liver Lobule
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    SLAMF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLAMF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523660

    UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature
    thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation

        Custom PCR Arrays for SLAMF1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLAMF1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLAMF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLAMF1
    QuantiTect SYBR Green Assays in human, mouse, rat SLAMF1
    QuantiFast Probe-based Assays in human, mouse, rat SLAMF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SLAMF1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slamf11 , 5 signaling lymphocytic activation molecule family member more1, 5 74.83(n)1
    62.09(a)1
      1 (79.54 cM)5
    272181  NM_013730.41  NP_038758.21 
     1717671275 
    chicken
    (Gallus gallus)
    Aves SLAMF11 signaling lymphocytic activation molecule family member more 47.12(n)
    35.26(a)
      425300  XM_423077.4  XP_423077.3 


    ENSEMBL Gene Tree for SLAMF1 (if available)
    TreeFam Gene Tree for SLAMF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLAMF1 gene
    1 SIMAP similar gene for SLAMF1 using alignment to 4 protein entries:     SLAF1_HUMAN (see all proteins):
    SLAM

    SLAMF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLAMF1 (see all 932)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355244
    A breast cancer sample4--see VAR_0355242 L F mis40--------
    rs75286071,2
    C,F,A,H--160579489(+) TTCAAA/GGATTT 1 -- int15Minor allele frequency- G:0.01NS EA NA 532
    rs1872633721,2
    --160579509(+) AGACCA/GAAATA 1 -- int10--------
    rs75195131,2
    C,H--160579799(+) TGCTAC/TGTTTT 1 -- int1 ese35Minor allele frequency- T:0.00NS EA NA 532
    rs37965031,2
    C,H--160579806(+) TTTTTC/ATTTAA 1 -- int1 ese39Minor allele frequency- A:0.00MN NS EA 820
    rs92828491,2
    C,F--160579815(-) CATTCA/CGTTTT 1 -- int15Minor allele frequency- C:0.01MN 404
    rs1926005601,2
    --160579943(+) CAAATA/GAAATA 1 -- ut310--------
    rs10612171,2
    C,F,A,H--160580015(-) GAGGCT/CGAAGG 1 -- ut31 ese336Minor allele frequency- C:0.48EA MN NA NS WA CSA 3457
    rs92828501,2
    F--160580045(-) CAGTTT/-CTCTC 1 -- ut31 trp35Minor allele frequency- -:0.01MN 400
    rs92828511,2
    C,F--160580065(-) CTGATC/GAAGCC 1 -- ut315Minor allele frequency- G:0.01MN 396

    HapMap Linkage Disequilibrium report for SLAMF1 (160577890 - 160617085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLAMF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv872491CNV Loss21882294
    nsv831714CNV Gain17160897
    nsv831703CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLAMF1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLAMF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603492    OMIM disorders: --

    Selected diseases for SLAMF1 (see all 31):    
    About MalaCards
    dysgammaglobulinemia    measles    subacute sclerosing panencephalitis    stomatitis
    hemophagocytic lymphohistiocytosis    protein s deficiency    allergic rhinitis    multiple sclerosis
    conjunctivitis    rhinitis    lung cancer susceptibility    blindness
    crohn's disease    systemic lupus erythematosus    chronic lymphocytic leukemia    lupus erythematosus
    breast and colorectal cancer    hodgkin's lymphoma    tuberculosis    inflammatory bowel disease

    1 disease from the University of Copenhagen DISEASES database for SLAMF1:
    Measles

    SLAMF1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SLAMF1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 93.3 4 14523387 (1), 12766168 (1), 11313386 (1), 10229804 (1)
    x-linked lymphoproliferative syndrome 91.9 3 11313386 (1), 12458214 (1), 11099315 (1)
    measles 82.8 50 16889684 (2), 11950898 (2), 20071568 (2), 12270725 (2) (see all 23)
    distemper canine 75.1 6 12941904 (2), 16963735 (1), 16495625 (1), 12917459 (1)
    subacute sclerosing panencephalitis 68.4 2 11950898 (2)
    ebv infections 61.7 2 9774102 (1), 12766168 (1)
    vesicular stomatitis 55 2 11160657 (1)
    immunodeficiency 41.3 1 12766168 (1)
    virus infection 24.3 6 11376478 (1), 11244050 (1), 20042501 (1), 17135325 (1)
    hodgkin disease 15.3 5 15315965 (2), 15812353 (2)

    Genetic Association Database (GAD): SLAMF1
    Human Genome Epidemiology (HuGE) Navigator: SLAMF1 (7 documents)

    Export disorders for SLAMF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLAMF1 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with SLAMF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel receptor involved in T-cell activation. (PubMed id 7617038)1, 2, 3 Cocks B.G....Aversa G. (Nature 1995)
    2. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PubMed id 10229804)1, 2, 9 Mikhalap S.V....Sidorenko S.P. (J. Immunol. 1999)
    3. SAP couples Fyn to SLAM immune receptors. (PubMed id 12545174)1, 2, 9 Chan B.... Eck M.J. (Nat. Cell Biol. 2003)
    4. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. (PubMed id 9774102)1, 2, 9 Sayos J.... Terhorst C. (Nature 1998)
    5. Genome-wide association study of treatment refractory schizophrenia in Han Chinese. (PubMed id 22479419)1, 4 Liou Y.J....Wu J.Y. (PLoS ONE 2012)
    6. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Detection and functional evaluation of -262A/T and -188A/G polymorphisms of SLAM gene in patients with systemic lupus erythematosus. (PubMed id 20810499)1, 4 You Y....Hao F. (J. Rheumatol. 2010)
    9. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6504 HGNC: 10903 AceView: SLAMF1 Ensembl:ENSG00000117090 euGenes: HUgn6504
    ECgene: SLAMF1 Kegg: 6504 H-InvDB: SLAMF1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLAMF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLAMF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLAMF1 gene:
    Search GeneIP for patents involving SLAMF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLAMF1
     
     EMD Millipore genomic analysis products

      
     Antibodies for SLAMF1 (SLAM/CD150)   Browse Cell Culture Products  
     ELISAs for SLAMF1 (SLAM/CD150)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for SLAMF1 (SLAM/CD150)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for SLAMF1 (SLAM/CD150)  
     OriGene Antibodies for SLAMF1   OriGene RNAi products in human, mouse, rat for SLAMF1  
     OriGene qPCR primer pairs and template standards for SLAMF1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLAMF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLAMF1   OriGene Purified Protein for SLAMF1  
     OriGene ORF clones in mouse, rat for SLAMF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLAMF1   OriGene Custom Protein Services for SLAMF1  

     
     
     Block miRNA regulation of human, mouse, rat SLAMF1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLAMF1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLAMF1 Predesigned siRNA for gene silencing in human, mouse, rat SLAMF1
     QuantiFast Probe-based Assays in human, mouse, rat SLAMF1 QuantiTect SYBR Green Assays in human, mouse, rat SLAMF1
     Custom PCR Arrays for SLAMF1 Search Chromatin IP Primers for SLAMF1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLAMF1  GeneGlobe Interaction Network for SLAMF1
     Regulatory tfbs in SLAMF1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLAMF1 GenScript cDNA clones with any tag delivered in your preferred vector for SLAMF1
     GenScript Custom Assay Services for SLAMF1 GenScript Custom overexpressing Cell Line Services for SLAMF1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLAMF1 (SLAF1)
     Proteins for SLAMF1
     Cell Lysates for SLAMF1
     cDNA Clones for SLAMF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLAMF1 antibodies
     SLAMF1 proteins
     SLAMF1 lysates
     Antibodies for SLAMF1
     See all of Abcam's Antibodies, Kits and Proteins for SLAMF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SLAMF1
     Proteins for SLAMF1
     Antibodies for SLAMF1
     ELISAs for SLAMF1
     CLIAs for SLAMF1



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLAMF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAMF1
     SwitchGear 3'UTR luciferase reporter plasmids for SLAMF1
     SwitchGear Promoter luciferase reporter plasmids for SLAMF1
     ThermoFisher Antibodies for SLAMF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLAMF1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLAMF1
     LSBio Antibodies in human, mouse, rat for SLAMF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLAMF1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4