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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLAMF1 Gene

protein-coding   GIFtS: 63
GCID: GC01M160577

signaling lymphocytic activation molecule family member...

(Previous name: signaling lymphocytic activation molecule )
(Previous symbol: SLAM)
 Explore 28 diseases affiliated with
SLAMF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLAMF1    

Aliases
for SLAMF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Signaling Lymphocytic Activation Molecule Family Member 11 2     CDw1502 3
SLAM1 2 3 5     IPO-32 3
CD1501 2 5     CD150 Antigen3
Signaling Lymphocytic Activation Molecule1 2     CDW1505

External Ids:    HGNC: 109031   Entrez Gene: 65042   Ensembl: ENSG000001170907   OMIM: 6034925   UniProtKB: Q132913   

Export aliases for SLAMF1 gene to outside databases

Previous GC identifers: GC01M157796 GC01M157392 GC01M158844 GC01M131936


Summaries
for SLAMF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced
signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are
likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine
phosphatase 2C (PTPN11)-dependent signal transduction operates

Gene Wiki entry for SLAMF1


Genomic Views
for SLAMF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLAMF1 gene promoter:
         AP-2alpha isoform 3   ATF-2   MyoD   AP-2alpha isoform 2   CRE-BP1   AREB6   IRF-7A   AP-2alpha isoform 4   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLAMF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLAMF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAMF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23.3

SLAMF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAMF1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160577:  view genomic region     (about GC identifiers)

Start:
 160,577,890 bp from pter      End:
 160,617,085 bp from pter
Size:
 39,196 bases      Orientation:
 minus strand

Proteins
for SLAMF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291 (See protein sequence)
Recommended Name: Signaling lymphocytic activation molecule precursor  
Size: 335 amino acids; 37231 Da
Subunit: Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles
virus H protein and acts as a receptor for this virus
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and
T-cells
6/9 PDB 3D structures from and Proteopedia for SLAMF1 (see all 9):
1D4T (3D)        1D4W (3D)        1KA6 (3D)        1KA7 (3D)        1M27 (3D)        2DZF (3D)    
Secondary accessions: Q5W172
Alternative splicing: 3 isoforms:  Q13291-1   Q13291-2   Q13291-3   

Explore the universe of human proteins at neXtProt for SLAMF1: NX_Q13291

Post-translational modifications:

  • Phosphorylated by FYN1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13291

    • SLAMF1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003028.1  
    ENSEMBL proteins: 
     ENSP00000306190   ENSP00000235739   ENSP00000438406   ENSP00000347333  

    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for SLAMF1 (SLAM/CD150)
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for SLAMF1 
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    Novus Biologicals SLAMF1 Proteins
    Novus Biologicals SLAMF1 Lysate
    Sino Biological Recombinant Protein for SLAMF1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLAMF1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface ----
    GO:0016021integral to membrane IEA--


    SLAMF1 for ontologies           About GeneDecksing



    SLAMF1 Antibody Products: 
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    ThermoFisher Antibodies for SLAMF1

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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLAMF1

    Protein Domains /
    Families
    for SLAMF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLAMF1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR015631 SLAM_fam_rcpts
     IPR010407 Sig_lymph_act_molc_N

    Graphical View of Domain Structure for InterPro Entry Q13291

    ProtoNet protein and cluster: Q13291

    UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Domain: The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be
    phosphorylated on tyrosine residues
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for SLAMF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Function: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced
    signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are
    likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine
    phosphatase 2C (PTPN11)-dependent signal transduction operates

    miRNA
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    hsa-miR-3163 hsa-miR-3659 hsa-miR-2114 hsa-miR-759 hsa-miR-3190 hsa-miR-518a-5p hsa-miR-323-5p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SLAMF1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLAMF1 (see all 7)
    OriGene shRNA RFP: SLAMF1
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SLAMF1 (NM_003037)
    Sino Biological Human cDNA Clone for SLAMF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAMF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAMF1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SLAMF1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003823antigen binding TAS7617038
    GO:0004872receptor activity ----
    GO:0004888transmembrane signaling receptor activity TAS7617038
    GO:0005515protein binding IPI--


    SLAMF1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SLAMF1: Slamf1tm1Cpt Slamf1tm1Vei
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Slamf1):
     cellular  hematopoietic system  immune system 

    SLAMF1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLAMF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Measles
    		Measles1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SLAMF1):
        Measles


    SLAMF1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLAMF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/10 Interacting proteins for SLAMF1 (Q132911, 2, 3 ENSP000003061904) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH2D1AO608802, 3, ENSP000003601814MINT-8031819 MINT-8031894 MINT-8031924 MINT-59435 MINT-8031803 MINT-8031939 MINT-8031784 MINT-8031668 MINT-8031709 MINT-8031694 MINT-8031879 MINT-8031909 MINT-8027270 I2D: score=8 STRING: ENSP00000360181
    PTPN11Q061242, 3, ENSP000003409444MINT-8031754 MINT-8031769 I2D: score=5 STRING: ENSP00000340944
    INPP5DQ928352, 3, ENSP000003525754MINT-8031724 MINT-8031739 I2D: score=2 STRING: ENSP00000352575
    SH2D1BO147962, 3, ENSP000003569064MINT-8031683 I2D: score=4 STRING: ENSP00000356906
    FYNP062413, ENSP000003576564I2D: score=4 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation TAS7617038
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----
    GO:0046649lymphocyte activation IEA--


    SLAMF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLAMF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLAMF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLAMF1
    3 Novoseek chemical compound relationships for SLAMF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 41.4 18 11313386 (4), 11806999 (3), 11689425 (2), 10229804 (2) (see all 9)
    phosphotyrosine 40.7 2 11689425 (1), 10607564 (1)
    inositol 25.5 5 11313386 (2), 15315965 (2), 10229804 (1)

    Search CenterWatch for drugs/clinical trials and news about SLAMF1 / SLAF1 

    Transcripts
    for SLAMF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLAMF1 gene: 
    NM_003037.2  

    Unigene Cluster for SLAMF1:

    Signaling lymphocytic activation molecule family member 1
    Hs.523660  [show with all ESTs]
    Unigene Representative Sequence: NM_003037
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302035(uc001fwl.4 uc010pjk.2 uc010pjl.2 uc010pjm.2)
    ENST00000497223 ENST00000494463 ENST00000235739 ENST00000538290 ENST00000355199(uc001fwm.3)


    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAMF1:
    hsa-miR-3163 hsa-miR-3659 hsa-miR-2114 hsa-miR-759 hsa-miR-3190 hsa-miR-518a-5p hsa-miR-323-5p hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SLAMF1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLAMF1 (see all 7)
    OriGene shRNA RFP: SLAMF1
    OriGene siRNA: SLAMF1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK304237.1 AK311666.1 AK314244.1 AY040554.1 BC012602.1 BC110349.1 BC132792.1 BC144498.1 
    BC144499.1 BC144500.1 U33017.1 

    4 DOTS entries:

    DT.210509  DT.100738081  DT.100747441  DT.102837084 

    24/44 AceView cDNA sequences (see all 44):

    AY040554 CR590430 BF507546 BM676376 AA825199 BC067847 AA769421 BI911191 
    NM_003037 BX348938 BQ028153 BX482030 AW469535 AW340092 BM713255 BU616725 
    BX329073 AA458996 CB989224 BC012602 AW593108 U33017 AI224384 BP344458 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                          -                             -                           
    SP2:                          -                 -     -     -                           
    SP3:                          -                                                         
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for SLAMF1

    Expression
    for SLAMF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLAMF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAACCTGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLAMF1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    BoneBone MarrowHematopoietic Stem CellsBlood
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLAMF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLAMF1

    SOURCE GeneReport for Unigene cluster: Hs.523660

    UniProtKB/Swiss-Prot: SLAF1_HUMAN, Q13291
    Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and
    a proportion of B-cells, and is rapidly induced on naive T-cells after activation

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    In Situ
    Assay Products:     
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    Orthologs
    for SLAMF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SLAMF1 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLAMF11 signaling lymphocytic activation molecule family member more 45.93(n)
    34.29(a)    		   425300  XM_423077.3  XP_423077.3 


    ENSEMBL Gene Tree for SLAMF1 (if available)
    TreeFam Gene Tree for SLAMF1 (if available) 

    Paralogs
    for SLAMF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SLAMF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 NCBI SNPs in SLAMF1 are shown (see all 807)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs75286071,2
    		C,F,A,H,--160579489(+) TTCAAA/GGATTT 1 -- int15Minor allele frequency- G:0.01NS EA NA 532
    rs1872633721,2
    		--160579509(+) AGACCA/GAAATA 1 -- int10--------
    rs75195131,2
    		C,H,--160579799(+) TGCTAC/TGTTTT 1 -- int1 ese35Minor allele frequency- T:0.00NS EA NA 532
    rs37965031,2
    		C,H--160579806(+) TTTTTC/ATTTAA 1 -- int1 ese39Minor allele frequency- A:0.00MN NS EA 820
    rs92828491,2
    		C,F,--160579815(-) CATTCA/CGTTTT 1 -- int15Minor allele frequency- C:0.01MN 404
    rs1926005601,2
    		--160579943(+) CAAATA/GAAATA 1 -- ut310--------
    rs10612171,2
    		C,F,A,H,--160580015(-) GAGGCT/CGAAGG 1 -- ut31 ese336Minor allele frequency- C:0.48EA MN NA NS WA CSA 3457
    rs92828501,2
    		F--160580045(-) CAGTTT/-CTCTC 1 -- ut31 trp35Minor allele frequency- -:0.01MN 400
    rs92828511,2
    		C,--160580065(-) CTGATC/GAAGCC 1 -- ut315Minor allele frequency- G:0.01MN 396
    rs144131,2
    		C,F,H,--160580188(-) CTGAAA/TGCCAG 1 -- ut31 ese317Minor allele frequency- T:0.02MN NS EA NA WA 1268

    HapMap Linkage Disequilibrium report for SLAMF1 (160577890 - 160617085 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLAMF1: --

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    Disorders / Diseases
    for SLAMF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLAMF1 for disorders           About GeneDecksing

    OMIM gene information: 603492    OMIM disorders: --

    20/28 diseases for SLAMF1 (see all 28):    About MalaCards
    subacute sclerosing panencephalitis    hemophagocytic lymphohistiocytosis    lymphoproliferative syndrome    infectious mononucleosis
    dysgammaglobulinemia    systemic lupus erythematosus    allergic rhinitis    lupus erythematosus
    chronic lymphocytic leukemia    multiple sclerosis    stomatitis    lymphocytic leukemia
    measles    rhinitis    hodgkin's lymphoma    protein s deficiency
    crohn's disease    hepatitis b    conjunctivitis    pulmonary disease

    2 diseases from the University of Copenhagen DISEASES database for SLAMF1:
    Measles     Infectious mononucleosis

    10/14 Novoseek disease relationships for SLAMF1 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoproliferative syndrome 93.3 4 14523387 (1), 12766168 (1), 11313386 (1), 10229804 (1)
    x-linked lymphoproliferative syndrome 91.9 3 11313386 (1), 12458214 (1), 11099315 (1)
    measles 82.8 50 16889684 (2), 11950898 (2), 20071568 (2), 12270725 (2) (see all 23)
    distemper canine 75.1 6 12941904 (2), 16963735 (1), 16495625 (1), 12917459 (1)
    subacute sclerosing panencephalitis 68.4 2 11950898 (2)
    ebv infections 61.7 2 9774102 (1), 12766168 (1)
    vesicular stomatitis 55 2 11160657 (1)
    immunodeficiency 41.3 1 12766168 (1)
    virus infection 24.3 6 11376478 (1), 11244050 (1), 20042501 (1), 17135325 (1)
    hodgkin disease 15.3 5 15315965 (2), 15812353 (2)

    Genetic Association Database (GAD): SLAMF1
    Human Genome Epidemiology (HuGE) Navigator: SLAMF1 (7 documents)

    Export disorders for SLAMF1 gene to outside databases

    Publications
    for SLAMF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLAMF1 gene, integrated from 9 sources (see all 148):
    (articles sorted by number of sources associating them with SLAMF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel receptor involved in T-cell activation. (PubMed id 7617038)1, 2, 3 Cocks B.G....Aversa G. (1995)
    2. CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. (PubMed id 10229804)1, 2, 9 Mikhalap S.V....Sidorenko S.P. (1999)
    3. SAP couples Fyn to SLAM immune receptors. (PubMed id 12545174)1, 2, 9 Chan B....Eck M.J. (2003)
    4. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. (PubMed id 9774102)1, 2, 9 Sayos J.... Terhorst C. (1998)
    5. Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients. (PubMed id 12629654)1, 4 Ferrand V.... Yin L. (2003)
    6. SLAM (CDw150) is a cellular receptor for measles virus. (PubMed id 10972291)1, 2 Tatsuo H.... Yanagi Y. (2000)
    7. Enhancement of anti-tumor activity in vitro and in vivo by CD150 and SAP. (PubMed id 17692919)1, 9 Mehrle S....Marten A. (2008)
    8. Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification. (PubMed id 12270725)1, 9 Murabayashi N....Seya T. (2002)
    9. The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells. (PubMed id 15315965)1, 9 Mikhalap S.V....Sidorenko S.P. (2004)
    10. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. (PubMed id 11806999)1, 9 Howie D....Terhorst C. (2002)

    External Searches for SLAMF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing SLAMF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6504 HGNC: 10903 AceView: SLAMF1 Ensembl:ENSG00000117090 euGenes: HUgn6504
    ECgene: SLAMF1 Kegg: 6504 H-InvDB: SLAMF1

    Other Databases showing SLAMF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLAMF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLAMF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLAMF1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SLAMF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLAMF1 gene:
    Search GeneIP for patents involving SLAMF1

    GeneCards and IP:
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