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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLAIN2 Gene

protein-coding   GIFtS: 50
GCID: GC04P048343

SLAIN Motif Family, Member 2

(Previous name: KIAA1458)
(Previous symbol: KIAA1458)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SLAIN Motif Family, Member 21 2
KIAA14581 2 3
SLAIN Motif-Containing Protein 22

External Ids:    HGNC: 292821   Entrez Gene: 576062   Ensembl: ENSG000001091717   OMIM: 6104925   UniProtKB: Q9P2703   

Export aliases for SLAIN2 gene to outside databases

Previous GC identifers: GC04P047991 GC04P047663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLAIN2 Gene: 
SLAIN2 (SLAIN motif family, member 2) is a protein-coding gene. Diseases associated with SLAIN2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include protein binding. An important paralog of this gene is SLAIN1.

UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270
Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.
Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule
cytoskeleton during interphase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006238.11  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLAIN2 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pbx1a   Nkx2-2   E2F-2   E2F-1   E2F   HOXA5   ARP-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SLAIN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAIN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p12

SLAIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAIN2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P048343:  view genomic region     (about GC identifiers)

Start:
48,343,339 bp from pter      End:
48,428,229 bp from pter
Size:
84,891 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270 (See protein sequence)
Recommended Name: SLAIN motif-containing protein 2  
Size: 581 amino acids; 62543 Da
Subunit: Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3
Subcellular location: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of
growing microtubules
Sequence caution: Sequence=AAH31691.2; Type=Erroneous initiation; Sequence=BAA95982.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SLAIN2:
3RDV (3D)    
Secondary accessions: A8K4P1 Q8N5R3

Explore the universe of human proteins at neXtProt for SLAIN2: NX_Q9P270

Explore proteomics data for SLAIN2 at MOPED 

Post-translational modifications:

  • UniProtKB: Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not
    localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P270

  • SLAIN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLAIN2 Protein Expression
    REFSEQ proteins: NP_065897.1  
    ENSEMBL proteins: 
     ENSP00000264313   ENSP00000425923   ENSP00000426744   ENSP00000424473  

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    Cloud-Clone Corp. Proteins for SLAIN2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0035371colocalizes with microtubule plus end IDA--

    SLAIN2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026179 Slain

    Graphical View of Domain Structure for InterPro Entry Q9P270

    ProtoNet protein and cluster: Q9P270

    UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270
    Domain: The N-terminus forms a two-stranded coiled coil
    Similarity: Belongs to the SLAIN motif-containing family


    SLAIN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAI2_HUMAN, Q9P270
    Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.
    Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule
    cytoskeleton during interphase

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SLAIN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLAIN2:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLAIN2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLAIN2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLAIN2 (Q9P2702, 3 ENSP000002643134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3306673 I2D: score=1 STRING: ENSP00000309503
    CKAP5Q140083, ENSP000003465664I2D: score=1 STRING: ENSP00000346566
    GRB2ENSP000003390074STRING: ENSP00000339007
    SH3KBP1ENSP000003809214STRING: ENSP00000380921
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007020microtubule nucleation IMP--
    GO:0031113regulation of microtubule polymerization ----
    GO:0031116positive regulation of microtubule polymerization IMP--
    GO:0031122cytoplasmic microtubule organization IMP--

    SLAIN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLAIN2 (SLAI2)

    Search CenterWatch for drugs/clinical trials and news about SLAIN2 / SLAI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLAIN2 gene: 
    NM_020846.1  

    Unigene Cluster for SLAIN2:

    SLAIN motif family, member 2
    Hs.479677  [show with all ESTs]
    Unigene Representative Sequence: NM_020846
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264313(uc003gya.4) ENST00000506375 ENST00000512093 ENST00000505131
    ENST00000510595
    miRNA
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    hsa-miR-640 hsa-miR-106a hsa-miR-3653 hsa-miR-3074-3p hsa-miR-519a hsa-miR-637 hsa-miR-208b hsa-miR-376a*
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    Additional mRNA sequence: 

    AB040891.1 AK025264.1 AK026476.1 AK096470.1 AK291006.1 BC006139.1 BC007701.2 BC012067.1 
    BC031691.2 BC040993.1 

    8 DOTS entries:

    DT.313380  DT.100031691  DT.95135522  DT.95240369  DT.121272447  DT.100760647  DT.91812850  DT.97868506 

    24/215 AceView cDNA sequences (see all 215):

    AA033669 BU183215 AA011669 AW006251 BM795243 AI089385 BQ019733 BF197968 
    AI926631 AI201784 AI498485 AA417303 AI093245 AI701478 BQ006754 BU674233 
    BG118570 BC031691 AI992106 AI949699 AW589990 AI393546 AI095532 AA011654 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9
    SP1:                          -                       -     -           -         
    SP2:                                                  -                           
    SP3:                                                                              


    ECgene alternative splicing isoforms for SLAIN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLAIN2 expression in normal human tissues (normalized intensities)      SLAIN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLAIN2 Expression
    About this image


    SLAIN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             platelets   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius   
     
     Epithelium (Respiratory System)
             airway epithelial cells   
     
     Testis (Reproductive System)

    See SLAIN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLAIN2

    SOURCE GeneReport for Unigene cluster: Hs.479677

    UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270
    Tissue specificity: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in
    adult pancreas and spleen and in fetal brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLAIN2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slain21 , 5 SLAIN motif family, member 21, 5 91.03(n)1
    94.14(a)1
      5 (38.44 cM)5
    759911  NM_153567.21  NP_705795.21 
     729143045 
    chicken
    (Gallus gallus)
    Aves SLAIN21 SLAIN motif family, member 2 77.52(n)
    78.7(a)
      422766  XM_420719.3  XP_420719.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLAIN26
    SLAIN motif family, member 2
    69(a)
    1 ↔ 1
    GL343293.1(763927-802624)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd58c022 wufd58c02 73.96(n)   326023  BC055660.1 


    ENSEMBL Gene Tree for SLAIN2 (if available)
    TreeFam Gene Tree for SLAIN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLAIN2 gene
    SLAIN12  
    1 SIMAP similar gene for SLAIN2 using alignment to 4 protein entries:     SLAI2_HUMAN (see all proteins):
    SLAIN1

    SLAIN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1665 SNPs in SLAIN2 are shown (see all 1665)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711912221,2
    C--48296290(+) TCTCT-/CTGTGTC 1 -- int11Minor allele frequency- CT:0.00NA 2
    rs105725221,2
    C--48297096(+) GCCTC-/A/A   
       A
    /AAA
    AAAAA
    1 -- int11CSA 2
    rs1921073391,2
    --48341766(+) GGGTTC/TGCCTT 1 -- us2k10--------
    rs1158995451,2
    F--48341855(+) TTTTTA/CACCCT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1455698511,2
    --48342034(+) AAATAC/TGTTTT 1 -- us2k10--------
    rs1135723621,2
    C,F--48342046(+) TGCTAC/TGAATA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1499286141,2
    C--48342103(+) ACAAA-/CCCAAG 1 -- us2k10--------
    rs1486394691,2
    --48342283(+) TGCAGA/CATAAT 1 -- us2k10--------
    rs1846042401,2
    --48342352(+) GAAAAG/TAATCA 1 -- us2k10--------
    rs792534271,2
    F--48342361(+) CAGATA/GTGGCA 1 -- us2k12Minor allele frequency- G:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for SLAIN2 (48343339 - 48428229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLAIN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662770CNV Deletion23128226
    nsv528084CNV Loss19592680
    nsv509896CNV Loss20534489
    nsv470034CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610492    OMIM disorders: --

    2 diseases for SLAIN2:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma


    SLAIN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLAIN2
    Human Genome Epidemiology (HuGE) Navigator: SLAIN2 (1 document)

    Export disorders for SLAIN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLAIN2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with SLAIN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. (PubMed id 21646404)1, 2 van der Vaart B.... Akhmanova A. (2011)
    2. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    3. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PubMed id 16546155)1, 3 Hirst C.E....Elefanty A.G. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    6. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    9. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. (PubMed id 21706016)1 Bisson N....Pawson T. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57606 HGNC: 29282 AceView: KIAA1458 Ensembl:ENSG00000109171 euGenes: HUgn57606
    ECgene: SLAIN2 H-InvDB: SLAIN2

    (According to HUGE)
    About This Section
    HUGE: KIAA1458

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLAIN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLAIN2 gene:
    Search GeneIP for patents involving SLAIN2

    GeneCards and IP:
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