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Aliases for SLAIN2 Gene

Aliases for SLAIN2 Gene

  • SLAIN Motif Family Member 2 2 3 5
  • KIAA1458 2 3 4
  • SLAIN Motif Family, Member 2 3

External Ids for SLAIN2 Gene

Previous HGNC Symbols for SLAIN2 Gene

  • KIAA1458

Previous GeneCards Identifiers for SLAIN2 Gene

  • GC04P047991
  • GC04P047663

Summaries for SLAIN2 Gene

GeneCards Summary for SLAIN2 Gene

SLAIN2 (SLAIN Motif Family Member 2) is a Protein Coding gene. An important paralog of this gene is SLAIN1.

UniProtKB/Swiss-Prot for SLAIN2 Gene

  • Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAIN2 Gene

Genomics for SLAIN2 Gene

Regulatory Elements for SLAIN2 Gene

Promoters for SLAIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLAIN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLAIN2 Gene

Chromosome:
4
Start:
48,341,322 bp from pter
End:
48,426,212 bp from pter
Size:
84,891 bases
Orientation:
Plus strand

Genomic View for SLAIN2 Gene

Genes around SLAIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAIN2 Gene

Proteins for SLAIN2 Gene

  • Protein details for SLAIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P270-SLAI2_HUMAN
    Recommended name:
    SLAIN motif-containing protein 2
    Protein Accession:
    Q9P270
    Secondary Accessions:
    • A8K4P1
    • Q8N5R3

    Protein attributes for SLAIN2 Gene

    Size:
    581 amino acids
    Molecular mass:
    62543 Da
    Quaternary structure:
    • Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3.
    SequenceCaution:
    • Sequence=AAH31691.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA95982.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLAIN2 Gene

neXtProt entry for SLAIN2 Gene

Proteomics data for SLAIN2 Gene at MOPED

Post-translational modifications for SLAIN2 Gene

  • Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLAIN2 Gene

Antibody Products

No data available for DME Specific Peptides for SLAIN2 Gene

Domains & Families for SLAIN2 Gene

Protein Domains for SLAIN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLAIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P270

UniProtKB/Swiss-Prot:

SLAI2_HUMAN :
  • The N-terminus forms a two-stranded coiled coil.
  • Belongs to the SLAIN motif-containing family.
Domain:
  • The N-terminus forms a two-stranded coiled coil.
Family:
  • Belongs to the SLAIN motif-containing family.
genes like me logo Genes that share domains with SLAIN2: view

No data available for Gene Families for SLAIN2 Gene

Function for SLAIN2 Gene

Molecular function for SLAIN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.

Phenotypes for SLAIN2 Gene

GenomeRNAi human phenotypes for SLAIN2:
genes like me logo Genes that share phenotypes with SLAIN2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLAIN2 Gene

Localization for SLAIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAIN2 Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAIN2 Gene COMPARTMENTS Subcellular localization image for SLAIN2 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for SLAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IDA 21646404
genes like me logo Genes that share ontologies with SLAIN2: view

Pathways & Interactions for SLAIN2 Gene

SuperPathways for SLAIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IMP 21646404
GO:0031122 cytoplasmic microtubule organization IEA,IMP 21646404
genes like me logo Genes that share ontologies with SLAIN2: view

No data available for Pathways by source and SIGNOR curated interactions for SLAIN2 Gene

Drugs & Compounds for SLAIN2 Gene

No Compound Related Data Available

Transcripts for SLAIN2 Gene

Unigene Clusters for SLAIN2 Gene

SLAIN motif family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: -
SP3:

Relevant External Links for SLAIN2 Gene

GeneLoc Exon Structure for
SLAIN2
ECgene alternative splicing isoforms for
SLAIN2

Expression for SLAIN2 Gene

mRNA expression in normal human tissues for SLAIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLAIN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLAIN2 Gene



SOURCE GeneReport for Unigene cluster for SLAIN2 Gene Hs.479677

mRNA Expression by UniProt/SwissProt for SLAIN2 Gene

Q9P270-SLAI2_HUMAN
Tissue specificity: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain.
genes like me logo Genes that share expression patterns with SLAIN2: view

Protein tissue co-expression partners for SLAIN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLAIN2 Gene

Orthologs for SLAIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAIN2 35
  • 99.83 (n)
  • 99.83 (a)
SLAIN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLAIN2 36
  • 97 (a)
OneToOne
SLAIN2 35
  • 96.1 (n)
  • 97.07 (a)
dog
(Canis familiaris)
Mammalia SLAIN2 35
  • 92.03 (n)
  • 92.08 (a)
SLAIN2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slain2 16
Slain2 36
  • 90 (a)
OneToOne
Slain2 35
  • 91.03 (n)
  • 94.14 (a)
oppossum
(Monodelphis domestica)
Mammalia SLAIN2 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLAIN2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slain2 35
  • 90.92 (n)
  • 95.86 (a)
chicken
(Gallus gallus)
Aves SLAIN2 35
  • 78.53 (n)
  • 79.54 (a)
SLAIN2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLAIN2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491488 35
  • 70.28 (n)
  • 68.74 (a)
zebrafish
(Danio rerio)
Actinopterygii slain2 36
  • 55 (a)
OneToOne
slain2 35
  • 63.97 (n)
  • 65.98 (a)
wufd58c02 35
Species with no ortholog for SLAIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLAIN2 Gene

ENSEMBL:
Gene Tree for SLAIN2 (if available)
TreeFam:
Gene Tree for SLAIN2 (if available)

Paralogs for SLAIN2 Gene

Paralogs for SLAIN2 Gene

(1) SIMAP similar genes for SLAIN2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLAIN2: view

Variants for SLAIN2 Gene

Sequence variations from dbSNP and Humsavar for SLAIN2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs411261 -- 48,352,040(-) ATTCA(A/G)CTTTC intron-variant
rs417242 -- 48,359,970(+) CCAAC(A/G)TGGTG intron-variant
rs429969 -- 48,354,316(+) TGGGT(A/G)ATTAA intron-variant
rs432927 -- 48,347,315(-) TGGTA(C/T)TGAAG intron-variant
rs436979 -- 48,360,524(-) acctc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAIN2 Gene

Variant ID Type Subtype PubMed ID
nsv528084 CNV Loss 19592680
nsv509896 CNV Loss 20534489
esv2662770 CNV Deletion 23128226
nsv470034 CNV Gain 18288195

Variation tolerance for SLAIN2 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLAIN2 Gene

HapMap Linkage Disequilibrium report
SLAIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAIN2 Gene

Disorders for SLAIN2 Gene

Relevant External Links for SLAIN2

Genetic Association Database (GAD)
SLAIN2
Human Genome Epidemiology (HuGE) Navigator
SLAIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLAIN2

No disorders were found for SLAIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAIN2 Gene

Publications for SLAIN2 Gene

  1. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. (PMID: 21646404) van der Vaart B. … Akhmanova A. (J. Cell Biol. 2011) 3 4 67
  2. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PMID: 16546155) Hirst C.E. … Elefanty A.G. (Dev. Biol. 2006) 2 3
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3

Products for SLAIN2 Gene

Sources for SLAIN2 Gene

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