Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLAIN2 Gene

protein-coding GIFtS: 48
GCID: GC04P048343

SLAIN motif family, member 2

(Previous name: KIAA1458 )
(Previous symbol: KIAA1458)

Explore 2 diseases affiliated with
SLAIN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SLAIN Motif Family, Member 2¹ ²
KIAA1458¹ ² ³
FLJ21611¹
SLAIN Motif-Containing Protein 2²

External Ids:	HGNC: 29282¹	Entrez Gene: 57606²	Ensembl: ENSG00000109171⁷	OMIM: 610492⁵	UniProtKB: Q9P270³

Export aliases for SLAIN2 gene to outside databases

Previous GC identifers: GC04P047991 GC04P047663

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270

Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.

Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule

cytoskeleton during interphase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_006238.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLAIN2 gene promoter:
E2F-3a E2F-4 E2F-5 Pbx1a Nkx2-2 E2F-2 E2F-1 E2F HOXA5 ARP-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SLAIN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAIN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p11 Ensembl cytogenetic band: 4p11 HGNC cytogenetic band: 4p12

SLAIN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLAIN2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P048343: view genomic region (about GC identifiers)

Start:	48,343,339 bp from pter	End:	48,428,215 bp from pter
Size:	84,877 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270 (See protein sequence)

Recommended Name: SLAIN motif-containing protein 2

Size: 581 amino acids; 62543 Da

Subunit: Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3

Subcellular location: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing

microtubules

Sequence caution: Sequence=AAH31691.2; Type=Erroneous initiation; Sequence=BAA95982.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for SLAIN2:

3RDV (3D)

Secondary accessions: A8K4P1 Q8N5R3

Explore the universe of human proteins at neXtProt for SLAIN2: NX_Q9P270

Post-translational modifications:

Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at

microtubule plus ends and does not interact with MAPRE1 or CKAP5¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P270

SLAIN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065897.1

ENSEMBL proteins:

ENSP00000264313 ENSP00000425923 ENSP00000426744 ENSP00000424473

Human Recombinant Protein Products for SLAIN2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SLAIN2
	GenScript Custom Purified and Recombinant Proteins Services for SLAIN2
	Novus Biologicals SLAIN2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLAIN2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	--
GO:0015630	microtubule cytoskeleton	IDA	--
GO:0035371	colocalizes with microtubule plus end	IDA	--

SLAIN2 for ontologies About GeneDecksing

SLAIN2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLAIN2
	GenScript Custom Superior Antibodies Services for SLAIN2
	Novus Biologicals SLAIN2 Antibodies
	Abcam antibodies for SLAIN2
	Uscn Antibodies for SLAIN2
	ThermoFisher Antibody for SLAIN2

Assay Products for SLAIN2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLAIN2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLAIN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLAIN2 for domains About GeneDecksing

1 InterPro domain/family:

IPR026179 Slain

Graphical View of Domain Structure for InterPro Entry Q9P270

ProtoNet protein and cluster: Q9P270

UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270

Domain: The N-terminus forms a two-stranded coiled coil

Similarity: Belongs to the SLAIN motif-containing family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SLAI2_HUMAN, Q9P270

Function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization.

Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule

cytoskeleton during interphase

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

SLAIN2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SLAIN2:

Decreased viability with pacli

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLAIN2

miRNA Products:		OriGene 3'-UTR Clone: SLAIN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLAIN2
		8/154 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAIN2 (see all 154):
		hsa-miR-640 hsa-miR-106a hsa-miR-3653 hsa-miR-3074-3p hsa-miR-519a hsa-miR-637 hsa-miR-208b hsa-miR-376a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLAIN2 (see all 7) OriGene shRNA RFP: SLAIN2 OriGene siRNA: SLAIN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLAIN2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLAIN2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SLAIN2
			Sirion Biotech Customized adenovirus for overexpression of SLAIN2 Sirion Biotech Customized adenovirus for potent knockdown of SLAIN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLAIN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLAIN2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLAIN2 (NM_020846)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAIN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAIN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLAIN2
		Search LifeMap BioReagents cell lines for SLAIN2
		Sirion Biotech Customized stable knockdown cell line services for SLAIN2 Sirion Biotech Customized inducible knockdown cell line services for SLAIN2 Sirion Biotech Customized stable overexpressing cell line services for SLAIN2 Sirion Biotech Customized inducible overexpressing cell line services for SLAIN2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAIN2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLAIN2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for SLAIN2 (Q9P270^{2, 3} ENSP00000264313⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-3306673 I2D: score=1 STRING: ENSP00000309503
CKAP5	Q14008³, ENSP00000346566⁴	I2D: score=1 STRING: ENSP00000346566
GRB2	ENSP00000339007⁴	STRING: ENSP00000339007
SH3KBP1	ENSP00000380921⁴	STRING: ENSP00000380921

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007020	microtubule nucleation	IMP	--
GO:0031113	regulation of microtubule polymerization	--	--
GO:0031116	positive regulation of microtubule polymerization	IMP	--
GO:0031122	cytoplasmic microtubule organization	IMP	--

SLAIN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLAIN2
Search CenterWatch for drugs/clinical trials and news about SLAIN2 / SLAI2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLAIN2 gene:

NM_020846.1

Unigene Cluster for SLAIN2:

SLAIN motif family, member 2

Hs.479677 [show with all ESTs]

Unigene Representative Sequence: NM_020846

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264313(uc003gya.4) ENST00000506375 ENST00000512093 ENST00000505131

ENST00000506141(uc003gyb.1) ENST00000510595

miRNA Products:		OriGene 3'-UTR Clone: SLAIN2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLAIN2
		8/154 QIAGEN miScript miRNA Assays for microRNAs that regulate SLAIN2 (see all 154):
		hsa-miR-640 hsa-miR-106a hsa-miR-3653 hsa-miR-3074-3p hsa-miR-519a hsa-miR-637 hsa-miR-208b hsa-miR-376a*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLAIN2 (see all 7) OriGene shRNA RFP: SLAIN2 OriGene siRNA: SLAIN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLAIN2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLAIN2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLAIN2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLAIN2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SLAIN2 (NM_020846)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLAIN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAIN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLAIN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLAIN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLAIN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLAIN2

Additional cDNA sequence:

AB040891.1 AK025264.1 AK026476.1 AK096470.1 AK291006.1 BC006139.1 BC007701.2 BC012067.1

BC031691.2 BC040993.1

8 DOTS entries:

DT.313380 DT.100031691 DT.95135522 DT.95240369 DT.121272447 DT.100760647 DT.91812850 DT.97868506

24/215 AceView cDNA sequences (see all 215):

AI138449 AI275013 BQ686858 AA353662 AI738429 AI579993 CB529968 AI160614

BU521235 AI186466 CR621779 BQ008967 AW073808 AA456668 AW771350 AW368119

AW192527 AW196706 CB157681 BQ029264 AB040891 AW439812 AW771201 BX118871

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9
SP1:									-								-		-				-
SP2:																	-
SP3:

ECgene alternative splicing isoforms for SLAIN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLAIN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

SLAIN2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLAIN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLAIN2

SOURCE GeneReport for Unigene cluster: Hs.479677

UniProtKB/Swiss-Prot: SLAI2_HUMAN, Q9P270

Tissue specificity: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult

pancreas and spleen and in fetal brain

SABiosciences Custom PCR Arrays for SLAIN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLAIN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLAIN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLAIN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLAIN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAIN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SLAIN2 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Slain2^{1 , 5}	SLAIN motif family, member 2^{1, 5}	91.03(n)¹ 94.14(a)¹		5 (38.44 cM)⁵ 75991¹ NM_153567.2¹ NP_705795.2¹ 72914304⁵
chicken (Gallus gallus)	Aves	SLAIN2¹	SLAIN motif family, member 2	77.52(n) 78.7(a)		422766 XM_420719.3 XP_420719.3
lizard (Anolis carolinensis)	Reptilia	SLAIN2⁶	--	76(a)	1 ↔ 1	GL343293.1(764073-802599)
zebrafish (Danio rerio)	Actinopterygii	wufd58c02²	wufd58c02	73.96(n)		326023 BC055660.1

ENSEMBL Gene Tree for SLAIN2 (if available)
TreeFam Gene Tree for SLAIN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLAIN2 gene

SLAIN1²

1 SIMAP similar gene for SLAIN2 using alignment to 4 protein entries: SLAI2_HUMAN (see all proteins):

SLAIN1

SLAIN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192107339^1,2		--	48341766(+)	`GGGTTC/TGCCTT`	1	--	us2k¹		0	--	--	--	--
rs115899545^1,2		--	48341855(+)	`TTTTTA/CACCCT`	1	--	us2k¹		1		WA	118
rs145569851^1,2		--	48342034(+)	`AAATAC/TGTTTT`	1	--	us2k¹		0	--	--	--	--
rs113572362^1,2	C	--	48342046(+)	`TGCTAC/TGAATA`	1	--	us2k¹		1		NA	2
rs149928614^1,2	C	--	48342103(+)	`ACAAA-/CCCAAG`	1	--	us2k¹		0	--	--	--	--
rs148639469^1,2		--	48342283(+)	`TGCAGA/CATAAT`	1	--	us2k¹		0	--	--	--	--
rs184604240^1,2		--	48342352(+)	`GAAAAG/TAATCA`	1	--	us2k¹		0	--	--	--	--
rs79253427^1,2		--	48342361(+)	`CAGATA/GTGGCA`	1	--	us2k¹		2		CSA WA	120
rs200066160^1,2	C	--	48342372(-)	`TATTCC/TCCGCC`	1	--	us2k¹		0	--	--	--	--
rs112028616^1,2	F	--	48342436(+)	`ACTCAG/CGTGTA`	1	--	us2k¹		2		CSA	4

HapMap Linkage Disequilibrium report for SLAIN2 (48343339 - 48428215 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLAIN2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLAIN2

DNA2.0 Custom Variant and Variant Library Synthesis for SLAIN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLAIN2 for disorders           About GeneDecksing

OMIM gene information: 610492    OMIM disorders: --

2 diseases for SLAIN2:    About MalaCards

intrahepatic cholangiocarcinoma cholangiocarcinoma

Human Genome Epidemiology (HuGE) Navigator: SLAIN2 (1 document)

Export disorders for SLAIN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLAIN2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SLAIN2)

Utopia: connect your pdf to the dynamic
world of online information

SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. (PubMed id 21646404)^{1, 2} van der Vaart B.... Akhmanova A. (2011)
Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PubMed id 16546155)^{1, 3} Hirst C.E....Elefanty A.G. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)¹ Segat L....Crovella S. (2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57606	HGNC: 29282	AceView: KIAA1458	Ensembl:ENSG00000109171	euGenes: HUgn57606
ECgene: SLAIN2	H-InvDB: SLAIN2

(According to HUGE)
About This Section

HUGE: KIAA1458

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLAIN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLAIN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLAIN2 gene:
Search GeneIP for patents involving SLAIN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SLAIN2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLAIN2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLAIN2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLAIN2		OriGene 3'-UTR Clone for SLAIN2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLAIN2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLAIN2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLAIN2		OriGene Custom Protein Services for SLAIN2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLAIN2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLAIN2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLAIN2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLAIN2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLAIN2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLAIN2

	GenScript Custom Purified and Recombinant Proteins Services for SLAIN2		GenScript cDNA clones with any tag delivered in your preferred vector for SLAIN2
	GenScript Custom Assay Services for SLAIN2		GenScript Custom Superior Antibodies Services for SLAIN2
	GenScript Custom overexpressing Cell Line Services for SLAIN2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SLAIN2 promoter
	Search Chromatin IP Primers for SLAIN2
	RT² qPCR Primer Assay in human, mouse, rat SLAIN2
	Search GNC Networks for SLAIN2
	SABiosciences Custom PCR Arrays for SLAIN2

Search Tocris compounds for SLAIN2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLAIN2 antibodies
	SLAIN2 proteins

	Antibodies for SLAIN2
	See all of Abcam's Antibodies, Kits and Proteins for SLAIN2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLAIN2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLAIN2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLAIN2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SLAIN2
	Browse SwitchGear Promoter luciferase reporter plasmids for SLAIN2

ThermoFisher Antibody for SLAIN2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLAIN2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLAIN2

Sirion Biotech Customized:

	stable knockdown cell line services for SLAIN2
	inducible knockdown cell line services for SLAIN2
	design and validation of potent shRNA sequences against SLAIN2
	adenovirus for potent knockdown of SLAIN2
	adenovirus for overexpression of SLAIN2
	stable overexpressing cell line services for SLAIN2
	inducible overexpressing cell line services for SLAIN2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLAIN2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SLAIN2 Gene

SLAIN motif family, member 2

Aliases
for SLAIN2 gene

Summaries
for SLAIN2 gene

Genomic Views
for SLAIN2 gene

Proteins
for SLAIN2 gene

Protein Domains /
Families
for SLAIN2 gene

Function
for SLAIN2 gene

Pathways & Interactions
for SLAIN2 gene

Drugs & Compounds
for SLAIN2 gene

Transcripts
for SLAIN2 gene

Expression
for SLAIN2 gene

Orthologs
for SLAIN2 gene

Paralogs
for SLAIN2 gene

Genomic Variants
for SLAIN2 gene

Disorders / Diseases
for SLAIN2 gene

Publications
for SLAIN2 gene

External Searches for SLAIN2 gene

Genome Databases showing SLAIN2 gene

Other Databases showing SLAIN2 gene

Specialized Databases showing SLAIN2 gene

Intellectual Property
for SLAIN2 gene

Products
for SLAIN2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SLAIN2 Gene

SLAIN motif family, member 2

Aliasesfor SLAIN2 gene

Summariesfor SLAIN2 gene

Genomic Viewsfor SLAIN2 gene

Proteinsfor SLAIN2 gene

Protein Domains /Familiesfor SLAIN2 gene

Functionfor SLAIN2 gene

Pathways & Interactionsfor SLAIN2 gene

Drugs & Compoundsfor SLAIN2 gene

Transcriptsfor SLAIN2 gene

Expression for SLAIN2 gene

Orthologsfor SLAIN2 gene

Paralogsfor SLAIN2 gene

Genomic Variantsfor SLAIN2 gene

Disorders / Diseasesfor SLAIN2 gene

Publicationsfor SLAIN2 gene

External Searches for SLAIN2 gene

Genome Databases showing SLAIN2 gene

Other Databases showing SLAIN2 gene

Specialized Databases showing SLAIN2 gene

Intellectual Propertyfor SLAIN2 gene

Productsfor SLAIN2 gene

View Random Gene

Aliases
for SLAIN2 gene

Summaries
for SLAIN2 gene

Genomic Views
for SLAIN2 gene

Proteins
for SLAIN2 gene

Protein Domains /
Families
for SLAIN2 gene

Function
for SLAIN2 gene

Pathways & Interactions
for SLAIN2 gene

Drugs & Compounds
for SLAIN2 gene

Transcripts
for SLAIN2 gene

Expression
for SLAIN2 gene

Orthologs
for SLAIN2 gene

Paralogs
for SLAIN2 gene

Genomic Variants
for SLAIN2 gene

Disorders / Diseases
for SLAIN2 gene

Publications
for SLAIN2 gene

Intellectual Property
for SLAIN2 gene

Products
for SLAIN2 gene