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Aliases for SLAIN1 Gene

Aliases for SLAIN1 Gene

  • SLAIN Motif Family Member 1 2 3 5
  • C13orf32 3 4
  • Chromosome 13 Open Reading Frame 32 2
  • SLAIN Motif-Containing Protein 1 3

External Ids for SLAIN1 Gene

Previous HGNC Symbols for SLAIN1 Gene

  • C13orf32

Previous GeneCards Identifiers for SLAIN1 Gene

  • GC13P077170
  • GC13P078272
  • GC13P058971

Summaries for SLAIN1 Gene

GeneCards Summary for SLAIN1 Gene

SLAIN1 (SLAIN Motif Family Member 1) is a Protein Coding gene. An important paralog of this gene is SLAIN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAIN1 Gene

Genomics for SLAIN1 Gene

Regulatory Elements for SLAIN1 Gene

Enhancers for SLAIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F077584 0.6 FANTOM5 25.9 -113.6 -113558 0.2 SLAIN1 SCEL-AS1 EDNRB MYCBP2 SCEL
GH13F077724 1.1 ENCODE 11.8 +26.4 26427 0.2 MTA2 IKZF1 MLLT1 TBX21 SLAIN1 GC13M077708 EDNRB-AS1
GH13F077730 0.3 FANTOM5 7.8 +32.7 32664 0.4 ZBED1 CBFB JUNB TRIM22 BMI1 EP300 CBX5 IKZF1 NBN TCF7 SLAIN1 GC13M077708 EDNRB-AS1
GH13F077304 1.5 FANTOM5 Ensembl ENCODE 2.1 -389.3 -389254 7.6 PKNOX1 ZNF362 FOXA3 JUN ZBTB40 ZNF121 SMARCA4 IKZF1 SPI1 CLN5 SLAIN1 MYCBP2 GC13P077273
GH13F077696 0.4 ENCODE 0.8 0.0 -24 3.5 HDGF PKNOX1 ZNF76 SIN3A FEZF1 GLIS2 EGR1 ZNF366 SCRT2 ZNF143 CLN5 FBXL3 RPL31P54 SLAIN1 LOC100129307
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLAIN1 on UCSC Golden Path with GeneCards custom track

Promoters for SLAIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000518014 46 3401 HDGF PKNOX1 ZNF76 SIN3A FEZF1 GLIS2 EGR1 ZNF366 SCRT2 CREM

Genomic Location for SLAIN1 Gene

Chromosome:
13
Start:
77,697,854 bp from pter
End:
77,764,242 bp from pter
Size:
66,389 bases
Orientation:
Plus strand

Genomic View for SLAIN1 Gene

Genes around SLAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAIN1 Gene

Proteins for SLAIN1 Gene

  • Protein details for SLAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND83-SLAI1_HUMAN
    Recommended name:
    SLAIN motif-containing protein 1
    Protein Accession:
    Q8ND83
    Secondary Accessions:
    • A8K0Z9
    • B7Z209
    • Q5T6P4
    • Q5T6P7
    • Q8ND10
    • Q96NV0

    Protein attributes for SLAIN1 Gene

    Size:
    568 amino acids
    Molecular mass:
    60595 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI11498.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD39000.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12505.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLAIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAIN1 Gene

Post-translational modifications for SLAIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLAIN1 Gene

Domains & Families for SLAIN1 Gene

Protein Domains for SLAIN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLAIN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8ND83

UniProtKB/Swiss-Prot:

SLAI1_HUMAN :
  • Belongs to the SLAIN motif-containing family.
Family:
  • Belongs to the SLAIN motif-containing family.
genes like me logo Genes that share domains with SLAIN1: view

No data available for Gene Families for SLAIN1 Gene

Function for SLAIN1 Gene

Gene Ontology (GO) - Molecular Function for SLAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLAIN1: view

Phenotypes for SLAIN1 Gene

MGI mutant phenotypes for SLAIN1:
inferred from 2 alleles
GenomeRNAi human phenotypes for SLAIN1:
genes like me logo Genes that share phenotypes with SLAIN1: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLAIN1 Gene

Localization for SLAIN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLAIN1 Gene COMPARTMENTS Subcellular localization image for SLAIN1 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLAIN1 Gene

Pathways & Interactions for SLAIN1 Gene

SuperPathways for SLAIN1 Gene

No Data Available

Interacting Proteins for SLAIN1 Gene

Gene Ontology (GO) - Biological Process for SLAIN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLAIN1 Gene

Transcripts for SLAIN1 Gene

Unigene Clusters for SLAIN1 Gene

SLAIN motif family, member 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - -
SP2:
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - -

Relevant External Links for SLAIN1 Gene

GeneLoc Exon Structure for
SLAIN1
ECgene alternative splicing isoforms for
SLAIN1

Expression for SLAIN1 Gene

mRNA expression in normal human tissues for SLAIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAIN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.6), Brain - Substantia nigra (x5.9), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for SLAIN1 Gene

This gene is overexpressed in Monocytes (20.7) and Lung (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLAIN1 Gene



Protein tissue co-expression partners for SLAIN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLAIN1 Gene:

SLAIN1

SOURCE GeneReport for Unigene cluster for SLAIN1 Gene:

Hs.349955

mRNA Expression by UniProt/SwissProt for SLAIN1 Gene:

Q8ND83-SLAI1_HUMAN
Tissue specificity: Expressed in embryonic stem cells.
genes like me logo Genes that share expression patterns with SLAIN1: view

Primer Products

Orthologs for SLAIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAIN1 34 35
  • 96.48 (n)
cow
(Bos Taurus)
Mammalia SLAIN1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLAIN1 34 35
  • 89.44 (n)
rat
(Rattus norvegicus)
Mammalia Slain1 34
  • 84.92 (n)
mouse
(Mus musculus)
Mammalia Slain1 34 16 35
  • 84.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLAIN1 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLAIN1 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLAIN1 34 35
  • 77.98 (n)
lizard
(Anolis carolinensis)
Reptilia SLAIN1 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slain1 34
  • 71.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2429 34
zebrafish
(Danio rerio)
Actinopterygii slain1a 34 35
  • 59.26 (n)
slain1b 35
  • 51 (a)
OneToMany
Species where no ortholog for SLAIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLAIN1 Gene

ENSEMBL:
Gene Tree for SLAIN1 (if available)
TreeFam:
Gene Tree for SLAIN1 (if available)

Paralogs for SLAIN1 Gene

Paralogs for SLAIN1 Gene

(1) SIMAP similar genes for SLAIN1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SLAIN1: view

Variants for SLAIN1 Gene

Sequence variations from dbSNP and Humsavar for SLAIN1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10444657 -- 77,754,585(+) TTTTC(C/T)TTCTT intron-variant
rs10599579 -- 77,723,947(+) AAAAA(-/A)CACAT intron-variant
rs10678746 -- 77,704,003(+) TATAC(-/AT)ATGTT intron-variant
rs10718987 -- 77,723,933(+) AGATT(-/A)AAAAA intron-variant
rs111216598 -- 77,704,259(+) GTTTT(A/C)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAIN1 Gene

Variant ID Type Subtype PubMed ID
dgv3262n54 CNV gain 21841781
dgv3263n54 CNV loss 21841781
esv1172184 CNV insertion 17803354
esv1521787 CNV insertion 17803354
esv23084 CNV loss 19812545
esv2747691 CNV deletion 23290073
esv2747692 CNV deletion 23290073
esv2747693 CNV deletion 23290073
nsv1070597 CNV deletion 25765185
nsv1120284 CNV tandem duplication 24896259
nsv1136173 CNV deletion 24896259
nsv562376 CNV loss 21841781
nsv562377 CNV gain 21841781
nsv562387 CNV loss 21841781
nsv562388 CNV loss 21841781
nsv951899 CNV duplication 24416366

Variation tolerance for SLAIN1 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLAIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLAIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAIN1 Gene

Disorders for SLAIN1 Gene

Relevant External Links for SLAIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLAIN1

No disorders were found for SLAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAIN1 Gene

Publications for SLAIN1 Gene

  1. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PMID: 16546155) Hirst C.E. … Elefanty A.G. (Dev. Biol. 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for SLAIN1 Gene

Sources for SLAIN1 Gene

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