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Aliases for SLAIN1 Gene

Aliases for SLAIN1 Gene

  • SLAIN Motif Family Member 1 2 3 5
  • C13orf32 3 4
  • Chromosome 13 Open Reading Frame 32 2
  • SLAIN Motif-Containing Protein 1 3

External Ids for SLAIN1 Gene

Previous HGNC Symbols for SLAIN1 Gene

  • C13orf32

Previous GeneCards Identifiers for SLAIN1 Gene

  • GC13P077170
  • GC13P078272
  • GC13P058971

Summaries for SLAIN1 Gene

GeneCards Summary for SLAIN1 Gene

SLAIN1 (SLAIN Motif Family Member 1) is a Protein Coding gene. An important paralog of this gene is SLAIN2.

UniProtKB/Swiss-Prot for SLAIN1 Gene

  • Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.

Additional gene information for SLAIN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAIN1 Gene

Genomics for SLAIN1 Gene

GeneHancer (GH) Regulatory Elements for SLAIN1 Gene

Promoters and enhancers for SLAIN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I077696 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 0.0 -23 3.4 HDGF PKNOX1 ARNT SIN3A FEZF1 BRCA1 GLIS2 ZNF143 RUNX3 SP3 MIR3665 SLAIN1 RPL31P54 LOC100129307
GH13I077742 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.3 +43.3 43346 0.1 POLR2A SLAIN1 GC13M077708 EDNRB-AS1
GH13I077744 Promoter/Enhancer 0.8 EPDnew dbSUPER 550.2 +45.2 45232 0.1 POLR2A SLAIN1 SCEL-AS1 GC13M077708 EDNRB-AS1
GH13I077741 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.3 +43.5 43483 0.1 SLAIN1 GC13M077708 EDNRB-AS1
GH13I077725 Enhancer 0.7 ENCODE dbSUPER 11.8 +26.4 26427 0.2 IKZF1 MLLT1 DPF2 IKZF2 RUNX3 SLAIN1 GC13M077708 EDNRB-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLAIN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLAIN1 gene promoter:

Genomic Locations for SLAIN1 Gene

Genomic Locations for SLAIN1 Gene
66,389 bases
Plus strand

Genomic View for SLAIN1 Gene

Genes around SLAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAIN1 Gene

Proteins for SLAIN1 Gene

  • Protein details for SLAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAIN motif-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K0Z9
    • B7Z209
    • Q5T6P4
    • Q5T6P7
    • Q8ND10
    • Q96NV0

    Protein attributes for SLAIN1 Gene

    568 amino acids
    Molecular mass:
    60595 Da
    Quaternary structure:
    • Interacts with MAPRE1, MAPRE2, MAPRE3 and CKAP5 (PubMed:21646404). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).
    • Sequence=AAI11498.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD39000.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12505.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLAIN1 Gene


neXtProt entry for SLAIN1 Gene

Post-translational modifications for SLAIN1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLAIN1 Gene

Domains & Families for SLAIN1 Gene

Gene Families for SLAIN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLAIN1 Gene


Suggested Antigen Peptide Sequences for SLAIN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLAIN motif-containing family.
  • Belongs to the SLAIN motif-containing family.
genes like me logo Genes that share domains with SLAIN1: view

Function for SLAIN1 Gene

Molecular function for SLAIN1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation.

Phenotypes From GWAS Catalog for SLAIN1 Gene

Gene Ontology (GO) - Molecular Function for SLAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SLAIN1: view

Phenotypes for SLAIN1 Gene

MGI mutant phenotypes for SLAIN1:
inferred from 2 alleles
GenomeRNAi human phenotypes for SLAIN1:
genes like me logo Genes that share phenotypes with SLAIN1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLAIN1 Gene

Localization for SLAIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAIN1 Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules. {ECO:0000269 PubMed:21646404}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAIN1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLAIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SLAIN1: view

Pathways & Interactions for SLAIN1 Gene

SuperPathways for SLAIN1 Gene

No Data Available

Interacting Proteins for SLAIN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8ND83-SLAI1_HUMAN ENSP00000418707 for SLAIN1 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for SLAIN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLAIN1 Gene

Drugs & Compounds for SLAIN1 Gene

No Compound Related Data Available

Transcripts for SLAIN1 Gene

Unigene Clusters for SLAIN1 Gene

SLAIN motif family, member 1:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - -

Relevant External Links for SLAIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLAIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAIN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.6), Brain - Substantia nigra (x5.9), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for SLAIN1 Gene

This gene is overexpressed in Monocytes (20.7) and Lung (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLAIN1 Gene

Protein tissue co-expression partners for SLAIN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLAIN1 Gene:


SOURCE GeneReport for Unigene cluster for SLAIN1 Gene:


mRNA Expression by UniProt/SwissProt for SLAIN1 Gene:

Tissue specificity: Expressed in embryonic stem cells (PubMed:16546155). Expressed in brain (PubMed:21646404).

Evidence on tissue expression from TISSUES for SLAIN1 Gene

  • Nervous system(4.9)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with SLAIN1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAIN1 Gene

Orthologs for SLAIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLAIN1 33 34
  • 96.48 (n)
(Bos Taurus)
Mammalia SLAIN1 34
  • 96 (a)
(Canis familiaris)
Mammalia SLAIN1 33 34
  • 89.44 (n)
(Rattus norvegicus)
Mammalia Slain1 33
  • 84.92 (n)
(Mus musculus)
Mammalia Slain1 33 16 34
  • 84.43 (n)
(Ornithorhynchus anatinus)
Mammalia SLAIN1 34
  • 83 (a)
(Monodelphis domestica)
Mammalia SLAIN1 34
  • 51 (a)
(Gallus gallus)
Aves SLAIN1 33 34
  • 77.98 (n)
(Anolis carolinensis)
Reptilia SLAIN1 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slain1 33
  • 71.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2429 33
(Danio rerio)
Actinopterygii slain1a 33 34
  • 59.26 (n)
slain1b 34
  • 51 (a)
Species where no ortholog for SLAIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLAIN1 Gene

Gene Tree for SLAIN1 (if available)
Gene Tree for SLAIN1 (if available)

Paralogs for SLAIN1 Gene

Paralogs for SLAIN1 Gene

(1) SIMAP similar genes for SLAIN1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SLAIN1: view

Variants for SLAIN1 Gene

Sequence variations from dbSNP and Humsavar for SLAIN1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000007779 -- 77,721,186(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000023798 -- 77,742,916(+) T/C intron_variant
rs1000032841 -- 77,697,360(+) C/G/T upstream_transcript_variant
rs1000054768 -- 77,742,592(+) G/A intron_variant
rs1000062170 -- 77,708,613(+) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLAIN1 Gene

Variant ID Type Subtype PubMed ID
dgv3262n54 CNV gain 21841781
dgv3263n54 CNV loss 21841781
esv1172184 CNV insertion 17803354
esv1521787 CNV insertion 17803354
esv23084 CNV loss 19812545
esv2747691 CNV deletion 23290073
esv2747692 CNV deletion 23290073
esv2747693 CNV deletion 23290073
nsv1070597 CNV deletion 25765185
nsv1120284 CNV tandem duplication 24896259
nsv1136173 CNV deletion 24896259
nsv562376 CNV loss 21841781
nsv562377 CNV gain 21841781
nsv562387 CNV loss 21841781
nsv562388 CNV loss 21841781
nsv951899 CNV duplication 24416366

Variation tolerance for SLAIN1 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLAIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAIN1 Gene

Disorders for SLAIN1 Gene

Additional Disease Information for SLAIN1

No disorders were found for SLAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAIN1 Gene

Publications for SLAIN1 Gene

  1. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PMID: 16546155) Hirst CE … Elefanty AG (Developmental biology 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Peptide array-based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase. (PMID: 28882895) Lemonidis K … Chamberlain LH (The Journal of biological chemistry 2017) 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for SLAIN1 Gene

Sources for SLAIN1 Gene

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