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Aliases for SLAIN1 Gene

Aliases for SLAIN1 Gene

  • SLAIN Motif Family Member 1 2 3 5
  • C13orf32 3 4
  • Chromosome 13 Open Reading Frame 32 2
  • SLAIN Motif Family, Member 1 3

External Ids for SLAIN1 Gene

Previous HGNC Symbols for SLAIN1 Gene

  • C13orf32

Previous GeneCards Identifiers for SLAIN1 Gene

  • GC13P077170
  • GC13P078272
  • GC13P058971

Summaries for SLAIN1 Gene

GeneCards Summary for SLAIN1 Gene

SLAIN1 (SLAIN Motif Family Member 1) is a Protein Coding gene. An important paralog of this gene is SLAIN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAIN1 Gene

Genomics for SLAIN1 Gene

Regulatory Elements for SLAIN1 Gene

Enhancers for SLAIN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLAIN1 on UCSC Golden Path with GeneCards custom track

Promoters for SLAIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLAIN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLAIN1 Gene

77,697,854 bp from pter
77,764,242 bp from pter
66,389 bases
Plus strand

Genomic View for SLAIN1 Gene

Genes around SLAIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAIN1 Gene

Proteins for SLAIN1 Gene

  • Protein details for SLAIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAIN motif-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K0Z9
    • B7Z209
    • Q5T6P4
    • Q5T6P7
    • Q8ND10
    • Q96NV0

    Protein attributes for SLAIN1 Gene

    568 amino acids
    Molecular mass:
    60595 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI11498.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD39000.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12505.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SLAIN1 Gene


neXtProt entry for SLAIN1 Gene

Proteomics data for SLAIN1 Gene at MOPED

Post-translational modifications for SLAIN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SLAIN1 Gene

Domains & Families for SLAIN1 Gene

Protein Domains for SLAIN1 Gene


Suggested Antigen Peptide Sequences for SLAIN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLAIN motif-containing family.
  • Belongs to the SLAIN motif-containing family.
genes like me logo Genes that share domains with SLAIN1: view

No data available for Gene Families for SLAIN1 Gene

Function for SLAIN1 Gene

Phenotypes for SLAIN1 Gene

MGI mutant phenotypes for SLAIN1:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with SLAIN1: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLAIN1 Gene

Localization for SLAIN1 Gene

Subcellular locations from

Jensen Localization Image for SLAIN1 Gene COMPARTMENTS Subcellular localization image for SLAIN1 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SLAIN1 Gene

Pathways & Interactions for SLAIN1 Gene

SuperPathways for SLAIN1 Gene

No Data Available

Interacting Proteins for SLAIN1 Gene

Gene Ontology (GO) - Biological Process for SLAIN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLAIN1 Gene

Drugs & Compounds for SLAIN1 Gene

No Compound Related Data Available

Transcripts for SLAIN1 Gene

Unigene Clusters for SLAIN1 Gene

SLAIN motif family, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - -

Relevant External Links for SLAIN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAIN1 Gene

mRNA expression in normal human tissues for SLAIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAIN1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.6), Brain - Substantia nigra (x5.9), and Brain - Hippocampus (x4.6).

Protein differential expression in normal tissues from HIPED for SLAIN1 Gene

This gene is overexpressed in Monocytes (20.7) and Lung (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLAIN1 Gene

SOURCE GeneReport for Unigene cluster for SLAIN1 Gene Hs.349955

mRNA Expression by UniProt/SwissProt for SLAIN1 Gene

Tissue specificity: Expressed in embryonic stem cells.
genes like me logo Genes that share expression patterns with SLAIN1: view

Protein tissue co-expression partners for SLAIN1 Gene

Primer Products

Orthologs for SLAIN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAIN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SLAIN1 35
  • 89.44 (n)
  • 91.95 (a)
  • 64 (a)
(Mus musculus)
Mammalia Slain1 35
  • 84.43 (n)
  • 88.91 (a)
Slain1 16
Slain1 36
  • 62 (a)
(Pan troglodytes)
Mammalia SLAIN1 35
  • 96.48 (n)
  • 96.13 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Slain1 35
  • 84.92 (n)
  • 93.44 (a)
(Bos Taurus)
Mammalia SLAIN1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia SLAIN1 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia SLAIN1 36
  • 83 (a)
(Gallus gallus)
Aves SLAIN1 35
  • 77.98 (n)
  • 85.49 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia SLAIN1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slain1 35
  • 71.98 (n)
  • 73.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2429 35
(Danio rerio)
Actinopterygii slain1a 35
  • 59.26 (n)
  • 58.21 (a)
slain1a 36
  • 33 (a)
slain1b 36
  • 51 (a)
Species with no ortholog for SLAIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLAIN1 Gene

Gene Tree for SLAIN1 (if available)
Gene Tree for SLAIN1 (if available)

Paralogs for SLAIN1 Gene

Paralogs for SLAIN1 Gene

(1) SIMAP similar genes for SLAIN1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SLAIN1: view

Variants for SLAIN1 Gene

Sequence variations from dbSNP and Humsavar for SLAIN1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1279382 -- 77,713,287(-) ttagc(C/G)ctttg intron-variant
rs1279383 -- 77,712,693(-) taatt(A/C)tgtga intron-variant
rs1279384 -- 77,711,586(-) atagg(C/T)tatta intron-variant
rs1279385 -- 77,710,723(-) gtcca(C/G)agctg intron-variant
rs1279440 -- 77,716,916(+) gaagc(A/G)atgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLAIN1 Gene

Variant ID Type Subtype PubMed ID
esv23084 CNV Loss 19812545
esv1521787 CNV Insertion 17803354
esv1172184 CNV Insertion 17803354
esv2747691 CNV Deletion 23290073
esv2747692 CNV Deletion 23290073
esv2747693 CNV Deletion 23290073

Variation tolerance for SLAIN1 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLAIN1 Gene

Disorders for SLAIN1 Gene

Relevant External Links for SLAIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLAIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAIN1 Gene

Publications for SLAIN1 Gene

  1. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PMID: 16546155) Hirst C.E. … Elefanty A.G. (Dev. Biol. 2006) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLAIN1 Gene

Sources for SLAIN1 Gene