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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLA2 Gene

protein-coding   GIFtS: 55
GCID: GC20M035240

Src-like-adaptor 2


(Previous symbol: C20orf156)
 Explore 2 diseases affiliated with
SLA2 via our new
 Human Malady Compendium 
Biological research products
for SLA2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Src-Like-Adaptor 21 2     MARS2 3
C20orf1561 2 3     FLJ219921
SLAP-21 2 3     Src-Like Adapter Protein-22
SLAP22 3 5     Src-Like-Adapter 22
Modulator Of Antigen Receptor Signaling2 3     Src-Like Adapter Protein 23

External Ids:    HGNC: 173291   Entrez Gene: 841742   Ensembl: ENSG000001010827   OMIM: 6065775   UniProtKB: Q9H6Q33   

Export aliases for SLA2 gene to outside databases

Previous GC identifers: GC20M034969 GC20M035879 GC20M035926 GC20M034657 GC20M034674 GC20M031976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLA2:
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important
receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium
mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two
transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor
induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with
CBL, leading to a CBL dependent degradation of signaling proteins

Gene Wiki entry for SLA2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLA2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   AREB6   Pax-3   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

SLA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035240:  view genomic region     (about GC identifiers)

Start:
35,240,721 bp from pter      End:
35,274,619 bp from pter
Size:
33,899 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3 (See protein sequence)
Recommended Name: Src-like-adapter 2  
Size: 261 amino acids; 28585 Da
Subunit: Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain)
with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated)
Subcellular location: Cytoplasm
Subcellular location: Isoform 1: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and
intracellular vesicles, including late endosomal vesicles
Subcellular location: Isoform 2: Cytoplasm (Probable). Note=May be cytoplasmic and is not localized to membranes
Secondary accessions: A8K648 E1P5U1 E1P5U2 Q5TH27 Q5TH28 Q8WY18 Q96QI4 Q9H135
Alternative splicing, Alternative initiation: 4 isoforms:  Q9H6Q3-1   Q9H6Q3-2   Q9H6Q3-3   Q9H6Q3-4   (Produced by alternative initiation at Met-28 of isoform 2)

Explore the universe of human proteins at neXtProt for SLA2: NX_Q9H6Q3

Post-translational modifications:

  • Phosphorylated by CSF1R (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H6Q3

  • SLA2 Protein expression data from MOPED and PaxDb:    About this image 
    SLA2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_115590.1  NP_778252.1  

    ENSEMBL proteins: 
     ENSP00000262866   ENSP00000353890  

    Human Recombinant Protein Products for SLA2: 
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    Novus Biologicals SLA2 Protein
    Novus Biologicals SLA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLA2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS11696592
    GO:0005770late endosome IEA--
    GO:0005886plasma membrane TAS11891219
    GO:0010008endosome membrane NAS11696592
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    SLA2 for ontologies           About GeneDecksing



    SLA2 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLA2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9H6Q3

    ProtoNet protein and cluster: Q9H6Q3

    2 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
    Domain: The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated
    by higher level of protein expression
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAP2_HUMAN, Q9H6Q3
    Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor
    induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with
    CBL, leading to a CBL dependent degradation of signaling proteins

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IDA11891219
    GO:0005515protein binding IPI11891219
    GO:0047485protein N-terminus binding IPI11891219
         
    SLA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLA2:
     Decreased Salmonella enterica   Decreased nuclei size in G2M 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sla2):
     cellular  hematopoietic system  immune system 

    SLA2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Sla2tm1Amch for SLA2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLA2 

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SLA2 (see all 16):
    hsa-miR-623 hsa-miR-328 hsa-miR-1260b hsa-miR-204 hsa-miR-589 hsa-miR-761 hsa-miR-4306 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidSLA2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLA2 (see all 3)
    OriGene siRNA: SLA2
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SLA2 

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    Sirion Biotech Customized inducible overexpressing cell line services for SLA2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway1.00
    2TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells1.00


    2 BioSystems Pathways for SLA2 
        B Cell Receptor Signaling Pathway
    TCR signaling in naive CD4+ T cells


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for SLA2 (Q9H6Q32, 3 ENSP000002628664) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74748 MINT-74749 I2D: score=2 STRING: ENSP00000269571
    CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    LAMC2Q137533, ENSP000002641444I2D: score=1 STRING: ENSP00000264144
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11696592
    GO:0019724B cell mediated immunity TAS11891219
    GO:0030522intracellular receptor mediated signaling pathway TAS11891219
    GO:0042110T cell activation TAS11891219
    GO:0050776regulation of immune response NAS11696592

    SLA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLA2
    3 Novoseek chemical compound relationships for SLA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 60.5 1 11696592 (1)
    tyrosine 33.8 5 12024036 (2), 11696592 (2), 11891219 (1)
    calcium 8.92 1 11696592 (1)

    Search CenterWatch for drugs/clinical trials and news about SLA2 / SLAP2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLA2 gene (2 alternative transcripts): 
    NM_032214.3  NM_175077.2  

    Unigene Cluster for SLA2:

    Src-like-adaptor 2
    Hs.713578  [show with all ESTs]
    Unigene Representative Sequence: NM_032214
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262866(uc002xfu.3 uc002xfv.3) ENST00000360672

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SLA2 (see all 16):
    hsa-miR-623 hsa-miR-328 hsa-miR-1260b hsa-miR-204 hsa-miR-589 hsa-miR-761 hsa-miR-4306 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidSLA2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLA2

    Additional cDNA sequence: 

    AF290985.1 AF290986.1 AF326353.1 AK025645.1 AK291513.1 BC042041.1 

    5 DOTS entries:

    DT.100820465  DT.436670  DT.95157974  DT.95157975  DT.100820463 

    24/45 AceView cDNA sequences (see all 45):

    AF290985 NM_175077 AW366977 AW366963 AF326353 BC042041 BG677567 BU944126 
    BQ052468 AI476149 BQ054265 AL541041 NM_032214 AL844325 AI002059 AI476150 
    AL844307 AA309769 BF059756 AF290986 BF062179 BG178487 BX383606 AA305476 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLA2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                                                        
    SP2:                                            -                           
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for SLA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGTTTCACC
    SLA2 Expression
    About this image
    See SLA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLA2

    SOURCE GeneReport for Unigene cluster: Hs.713578

    UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
    Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes.
    Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in
    B-cells. Also detected in placenta, prostate, skin, retina and colon

        SABiosciences Custom PCR Arrays for SLA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLA2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008587501 src-like-adapter 2-like 62.63(n)
    55.65(a)
      100858750  XM_003642446.1  XP_003642494.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLA26
    --
    50(a)
    1 ↔ 1
    4(134678514-134682986)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689842 hypothetical protein MGC68984 71.16(n)    BC056035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sla21 Src-like-adaptor 2 57.64(n)
    44.62(a)
      568515  NM_001114435.1  NP_001107907.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G162706
    AT3G247156
    (see all 7)
    octicosapeptide/Phox/Be.1 domain-containing protei...
    octicosapeptide/Phox/Bem1p domain-containing prote...
    (see all 7)
    3(a)
    3(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    1(5563087-5568368)
    3(9025849-9029948)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 5)
    protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)
    3(a)
    3(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    3(16281357-16289129)
    6(26398279-26404234)


    ENSEMBL Gene Tree for SLA2 (if available)
    TreeFam Gene Tree for SLA2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLA2 gene
    SLA2  
    9 SIMAP similar genes for SLA2 using alignment to 1 protein entry:     SLAP2_HUMAN:
    LCK    BLK    HCK    FYN    FGR    LYN
    SLA    YES1    SRC

    SLA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/642 NCBI SNPs in SLA2 are shown (see all 642    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888255701,2
    --35241495(+) GTGTAC/TGCCTG 2 -- ut310--------
    rs1391596641,2
    --35241549(+) ATCCAA/GGAGAT 2 -- ut310--------
    rs1921483741,2
    --35241629(+) AAAAAA/TAGAAA 2 -- ut310--------
    rs1828591441,2
    --35241749(+) TGCTAC/TGGTAA 2 -- ut310--------
    rs1495181941,2
    --35241779(+) TTTCCC/TTTCTA 2 -- ut310--------
    rs413110491,2
    C--35241897(+) GGGGCC/GTGGTT 2 -- ut313Minor allele frequency- G:0.03NA WA 240
    rs1440257531,2
    --35241936(+) CAGGCA/TGGGCA 2 -- ut310--------
    rs61014361,2
    C,F,H--35242029(+) GCCCTG/AGTCCC 2 -- ut317Minor allele frequency- A:0.06NS NA WA 912
    rs455898381,2
    C,F--35242188(+) ACAGCC/TTTGCC 2 -- ut312Minor allele frequency- T:0.02NA EU 559
    rs60931441,2
    C,F--35242251(+) CCCTTT/GTGGCC 2 -- ut31 ese3 trp31Minor allele frequency- G:0.06WA 118

    HapMap Linkage Disequilibrium report for SLA2 (35240721 - 35274619 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SLA2
         1 Indel: 102961

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLA2 for disorders           About GeneDecksing

    OMIM gene information: 606577    OMIM disorders: --

    2 diseases for SLA2:    About MalaCards
    huntington's disease    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLA2:
    Blastomycosis
    Human Genome Epidemiology (HuGE) Navigator: SLA2 (1 document)

    Export disorders for SLA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLA2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SLA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PubMed id 11696592)1, 2, 3, 9 Holland S.J.... Wu J. (2001)
    2. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. (PubMed id 11891219)1, 2, 9 Pandey A.... Mann M. (2002)
    3. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. (PubMed id 12527895)1, 2, 9 Loreto M.P. and McGlade C.J. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. (PubMed id 12024036)1, 9 Loreto M.P....McGlade C.J. (2002)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. An integrative method for scoring candidate genes fro m association studies: application to warfarin dosing. (PubMed id 21044367)1 Tatonetti N.P....Altman R.B. (2010)
    10. Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI- mediated platelet activation SLAP-2 and GPVI signaling. (PubMed id 20828795)1 Sugihara S....Kimura A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84174 HGNC: 17329 AceView: SLA2 Ensembl:ENSG00000101082 euGenes: HUgn84174
    ECgene: SLA2 H-InvDB: SLA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLA2 gene:
    Search GeneIP for patents involving SLA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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