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Aliases for SLA2 Gene

Aliases for SLA2 Gene

  • Src-Like-Adaptor 2 2 3
  • SLAP2 3 4 6
  • Modulator Of Antigen Receptor Signaling 3 4
  • C20orf156 3 4
  • SLAP-2 3 4
  • MARS 3 4
  • Src-Like Adapter Protein-2 3
  • Src-Like Adapter Protein 2 4
  • Src-Like-Adapter 2 3

External Ids for SLA2 Gene

Previous Symbols for SLA2 Gene

  • C20orf156

Summaries for SLA2 Gene

Entrez Gene Summary for SLA2 Gene

  • This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLA2 Gene

SLA2 (Src-Like-Adaptor 2) is a Protein Coding gene. Diseases associated with SLA2 include blastomycosis. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways) and Gene Expression. GO annotations related to this gene include protein N-terminus binding and SH3/SH2 adaptor activity. An important paralog of this gene is SLA.

UniProtKB/Swiss-Prot for SLA2 Gene

  • Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Gene Wiki entry for SLA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLA2 Gene

Genomics for SLA2 Gene

Genomic Location for SLA2 Gene

Start:
36,612,318 bp from pter
End:
36,646,216 bp from pter
Size:
33,899 bases
Orientation:
Minus strand

Genomic View for SLA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLA2 Gene

Regulatory Elements for SLA2 Gene

Proteins for SLA2 Gene

  • Protein details for SLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Q3-SLAP2_HUMAN
    Recommended name:
    Src-like-adapter 2
    Protein Accession:
    Q9H6Q3
    Secondary Accessions:
    • A8K648
    • E1P5U1
    • E1P5U2
    • Q5TH27
    • Q5TH28
    • Q8WY18
    • Q96QI4
    • Q9H135

    Protein attributes for SLA2 Gene

    Size:
    261 amino acids
    Molecular mass:
    28585 Da
    Quaternary structure:
    • Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for SLA2 Gene

    Alternative splice isoforms for SLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLA2 Gene

Proteomics data for SLA2 Gene at MOPED

Post-translational modifications for SLA2 Gene

Other Protein References for SLA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLA2 Gene

Domains for SLA2 Gene

Gene Families for SLA2 Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for SLA2 Gene

UniProtKB/Swiss-Prot:

SLAP2_HUMAN
Domain:
  • The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression:
    • Q9H6Q3
  • Contains 1 SH2 domain.:
    • Q9H6Q3
  • Contains 1 SH3 domain.:
    • Q9H6Q3
genes like me logo Genes that share domains with SLA2: view

Function for SLA2 Gene

Molecular function for SLA2 Gene

UniProtKB/Swiss-Prot Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Gene Ontology (GO) - Molecular Function for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IDA 11891219
GO:0005515 protein binding IPI 11891219
GO:0047485 protein N-terminus binding IPI 11891219
genes like me logo Genes that share ontologies with SLA2: view
genes like me logo Genes that share phenotypes with SLA2: view

Animal Models for SLA2 Gene

MGI Knock Outs for SLA2:

miRNA for SLA2 Gene

miRTarBase miRNAs that target SLA2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLA2 Gene

Localization for SLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLA2 Gene

Cytoplasm.
Isoform 1: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2: Cytoplasm. Note=May be cytoplasmic and is not localized to membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLA2 Gene COMPARTMENTS Subcellular localization image for SLA2 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 11696592
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane TAS 11891219
GO:0010008 endosome membrane NAS 11696592
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with SLA2: view

Pathways for SLA2 Gene

genes like me logo Genes that share pathways with SLA2: view

Pathways by source for SLA2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SLA2 Gene

Gene Ontology (GO) - Biological Process for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11696592
GO:0009967 positive regulation of signal transduction IDA 11891219
GO:0019724 B cell mediated immunity TAS 11891219
GO:0030522 intracellular receptor signaling pathway TAS 11891219
GO:0042110 T cell activation TAS 11891219
genes like me logo Genes that share ontologies with SLA2: view

Compounds for SLA2 Gene

(3) Novoseek inferred chemical compound relationships for SLA2 Gene

Compound -log(P) Hits PubMed IDs
ionomycin 60.5 1
tyrosine 33.8 5
calcium 8.92 1
genes like me logo Genes that share compounds with SLA2: view

Transcripts for SLA2 Gene

Unigene Clusters for SLA2 Gene

Src-like-adaptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for SLA2 Gene

GeneLoc Exon Structure for
SLA2
ECgene alternative splicing isoforms for
SLA2

Expression for SLA2 Gene

mRNA expression in normal human tissues for SLA2 Gene

mRNA differential expression in normal tissues according to GTEx for SLA2 Gene

This gene is overexpressed in Whole Blood (34.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLA2 Gene

SOURCE GeneReport for Unigene cluster for SLA2 Gene Hs.713578

mRNA Expression by UniProt/SwissProt for SLA2 Gene

Q9H6Q3-SLAP2_HUMAN
Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon
genes like me logo Genes that share expressions with SLA2: view

Orthologs for SLA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLA2 36
  • 99.23 (n)
  • 98.85 (a)
SLA2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLA2 36
  • 88.08 (n)
  • 84.62 (a)
SLA2 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLA2 36
  • 86.03 (n)
  • 82.69 (a)
SLA2 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sla2 36
  • 81.52 (n)
  • 79.46 (a)
Sla2 16
Sla2 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLA2 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sla2 36
  • 81.67 (n)
  • 79.62 (a)
chicken
(Gallus gallus)
Aves SLA2 36
  • 66.83 (n)
  • 61 (a)
SLA2 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLA2 37
  • 45 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68984 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sla2 36
  • 59.08 (n)
  • 51.07 (a)
zebrafish
(Danio rerio)
Actinopterygii sla2 36
  • 57.41 (n)
  • 44.84 (a)
sla2 37
  • 41 (a)
OneToOne
Species with no ortholog for SLA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLA2 Gene

ENSEMBL:
Gene Tree for SLA2 (if available)
TreeFam:
Gene Tree for SLA2 (if available)

Paralogs for SLA2 Gene

Paralogs for SLA2 Gene

Selected SIMAP similar genes for SLA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLA2: view

Variants for SLA2 Gene

Sequence variations from dbSNP and Humsavar for SLA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs183399 -- 36,644,968(-) ATGGG(C/G)TACAT intron-variant
rs190088 -- 36,644,917(-) TGTAT(C/T)TGAAA intron-variant
rs191989 -- 36,644,924(-) TGGTC(A/C/G)CTGTA intron-variant
rs221308 -- 36,647,995(-) aaagc(C/T)ccaag upstream-variant-2KB
rs221309 -- 36,646,270(-) GAACT(C/T)GGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLA2 Gene

Variant ID Type Subtype PubMed ID
nsv833967 CNV Loss 17160897
esv2554197 CNV Insertion 19546169

Relevant External Links for SLA2 Gene

HapMap Linkage Disequilibrium report
SLA2

Disorders for SLA2 Gene

(1) MalaCards Diseases for SLA2 Gene

Search for SLA2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLA2 Gene

Relevant External Links for SLA2

Human Genome Epidemiology (HuGE) Navigator
SLA2
genes like me logo Genes that share disorders with SLA2: view

No data available for UniProtKB/Swiss-Prot for SLA2 Gene

Publications for SLA2 Gene

  1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PMID: 11696592) Holland S.J. … Wu J. (J. Exp. Med. 2001) 2 3 4 23
  2. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. (PMID: 11891219) Pandey A. … Mann M. (J. Biol. Chem. 2002) 3 4 23
  3. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. (PMID: 12527895) Loreto M.P. … McGlade C.J. (Oncogene 2003) 3 4 23
  4. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. (PMID: 12024036) Loreto M.P. … McGlade C.J. (Mol. Cell. Biol. 2002) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for SLA2 Gene

Sources for SLA2 Gene

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