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SLA2 Gene

protein-coding   GIFtS: 54
GCID: GC20M035240

Src-Like-Adaptor 2


(Previous symbol: C20orf156)
  See SLA2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src-Like-Adaptor 21 2     SLAP-22 3
C20orf1561 2 3     Src-Like Adapter Protein-22
SLAP22 3 5     Src-Like-Adapter 22
Modulator Of Antigen Receptor Signaling2 3     Src-Like Adapter Protein 23
MARS2 3     

External Ids:    HGNC: 173291   Entrez Gene: 841742   Ensembl: ENSG000001010827   OMIM: 6065775   UniProtKB: Q9H6Q33   

Export aliases for SLA2 gene to outside databases

Previous GC identifers: GC20M034969 GC20M035879 GC20M035926 GC20M034657 GC20M034674 GC20M031976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLA2 Gene:
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important
receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced
calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c.
Two transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SLA2 Gene:
SLA2 (Src-like-adaptor 2) is a protein-coding gene. Diseases associated with SLA2 include blastomycosis. GO annotations related to this gene include SH3/SH2 adaptor activity and protein N-terminus binding. An important paralog of this gene is SLA.

UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell
antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins
such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins

Gene Wiki entry for SLA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SLA2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   AREB6   Pax-3   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLA2 promoter sequence
   Search Chromatin IP Primers for SLA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

SLA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035240:  view genomic region     (about GC identifiers)

Start:
35,240,721 bp from pter      End:
35,274,619 bp from pter
Size:
33,899 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3 (See protein sequence)
Recommended Name: Src-like-adapter 2  
Size: 261 amino acids; 28585 Da
Subunit: Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2
domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL
(phosphorylated)
1 PDB 3D structure from and Proteopedia for SLA2:
4M4Z (3D)    
Secondary accessions: A8K648 E1P5U1 E1P5U2 Q5TH27 Q5TH28 Q8WY18 Q96QI4 Q9H135
Alternative splicing, Alternative initiation: 4 isoforms:  Q9H6Q3-1   Q9H6Q3-2   Q9H6Q3-3   Q9H6Q3-4   (Produced by alternative initiation at Met-28 of isoform 2)

Explore the universe of human proteins at neXtProt for SLA2: NX_Q9H6Q3

Explore proteomics data for SLA2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CSF1R (By similarity)1
  • Ubiquitination2 at Lys34
  • Modification sites at PhosphoSitePlus

  • See SLA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_115590.1  NP_778252.1  

    ENSEMBL proteins: 
     ENSP00000262866   ENSP00000353890  

    SLA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals SLA2 Proteins
    Novus Biologicals SLA2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SLA2

     
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    Cloud-Clone Corp. ELISAs for SLA2
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    Search eBioscience for ELISAs for SLA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q9H6Q3

    ProtoNet protein and cluster: Q9H6Q3

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
    Domain: The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially
    compensated by higher level of protein expression
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SLA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAP2_HUMAN, Q9H6Q3
    Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell
    antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins
    such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IDA11891219
    GO:0005515protein binding IPI11891219
    GO:0047485protein N-terminus binding IPI11891219
         
    Find genes that share ontologies with SLA2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLA2:
     Decreased Salmonella enterica   Decreased nuclei size in G2M 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sla2):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with SLA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sla2tm1Amch for SLA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLA2:
    hsa-mir-335-5p (MIRT018729)

    Block miRNA regulation of human, mouse, rat SLA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLA2 (see all 16):
    hsa-miR-623 hsa-miR-328 hsa-miR-1260b hsa-miR-204 hsa-miR-589 hsa-miR-761 hsa-miR-4306 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidSLA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLA2
    Predesigned siRNA for gene silencing in human, mouse, rat SLA2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SLA2

    Clone
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    OriGene clones in human, mouse for SLA2 (see all 12)
    OriGene ORF clones in mouse, rat for SLA2
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLA2 (NM_032214)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SLA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLAP2_HUMAN, Q9H6Q3: Cytoplasm
    SLAP2_HUMAN, Q9H6Q3: Isoform 1: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and
    intracellular vesicles, including late endosomal vesicles
    SLAP2_HUMAN, Q9H6Q3: Isoform 2: Cytoplasm (Probable). Note=May be cytoplasmic and is not localized to membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS11696592
    GO:0005770late endosome IEA--
    GO:0005886plasma membrane TAS11891219
    GO:0010008endosome membrane NAS11696592
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with SLA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLA2 About    
    See pathways by source

    SuperPathContained pathways About
    1TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    2B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    2 BioSystems Pathways for SLA2
        B Cell Receptor Signaling Pathway
    TCR signaling in naive CD4+ T cells


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLA2
    Interactions:

        GeneGlobe Interaction Network for SLA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for SLA2 (Q9H6Q31, 2, 3 ENSP000002628664) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-1222854,EBI-641062 MINT-74748 MINT-74749 I2D: score=2 STRING: ENSP00000269571
    CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    LAMC2Q137533, ENSP000002641444I2D: score=1 STRING: ENSP00000264144
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11696592
    GO:0009967positive regulation of signal transduction IDA11891219
    GO:0019724B cell mediated immunity TAS11891219
    GO:0030522intracellular receptor signaling pathway TAS11891219
    GO:0042110T cell activation TAS11891219

    Find genes that share ontologies with SLA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLA2 (SLAP2)

    3 Novoseek inferred chemical compound relationships for SLA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 60.5 1 11696592 (1)
    tyrosine 33.8 5 12024036 (2), 11696592 (2), 11891219 (1)
    calcium 8.92 1 11696592 (1)



    Find genes that share compounds with SLA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLA2 gene (2 alternative transcripts): 
    NM_032214.3  NM_175077.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262866(uc002xfu.3 uc002xfv.3) ENST00000360672
    miRNA
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    Block miRNA regulation of human, mouse, rat SLA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLA2 (see all 16):
    hsa-miR-623 hsa-miR-328 hsa-miR-1260b hsa-miR-204 hsa-miR-589 hsa-miR-761 hsa-miR-4306 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidSLA2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): SLA2 (NM_032214)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA2
    Primer
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    OriGene qPCR primer pairs and template standards for SLA2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLA2
      QuantiTect SYBR Green Assays in human, mouse, rat SLA2
      QuantiFast Probe-based Assays in human, mouse, rat SLA2

    Selected AceView cDNA sequences (see all 45):

    AF326353 AI476149 BU944126 AL541041 AF290985 AI476150 AW366977 BQ052468 
    BQ054265 NM_032214 AI002059 BG677567 NM_175077 AW366963 AL844325 BC042041 
    AA305476 BQ054281 BF062179 BG178487 AF290986 AW612786 AK025645 AA310216 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLA2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                                                        
    SP2:                                            -                           
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for SLA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTTCACC
    SLA2 Expression
    About this image

    SLA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLA2 Protein Expression

    UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
    Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes.
    Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in
    B-cells. Also detected in placenta, prostate, skin, retina and colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLA2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sla21 , 5 Src-like-adaptor 21, 5 81.52(n)1
    79.46(a)1
      2 (77.89 cM)5
    777991  NM_029983.51  NP_084259.11 
     1568724575 
    chicken
    (Gallus gallus)
    Aves SLA21 Src-like-adaptor 2 66.83(n)
    61(a)
      100858750  XM_003642446.2  XP_003642494.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLA26
    Src-like-adaptor 2
    45(a)
    1 ↔ 1
    4(134678505-134687916)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689842 hypothetical protein MGC68984 71.16(n)    BC056035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sla21 Src-like-adaptor 2 57.41(n)
    44.84(a)
      568515  NM_001114435.1  NP_001107907.1 


    ENSEMBL Gene Tree for SLA2 (if available)
    TreeFam Gene Tree for SLA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLA2 gene
    SLA2  
    9 SIMAP similar genes for SLA2 using alignment to 1 protein entry:     SLAP2_HUMAN:
    LCK    BLK    HCK    FYN    FGR    LYN
    SLA    YES1    SRC

    Find genes that share paralogs with SLA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLA2 (see all 851)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907420831,2
    Cuntested135205447(+) TTGATC/TGTTGG 2 -- ds50010--------
    rs1382442401,2
    C--35205345(+) TTGGAC/TCATCT 2 -- int10--------
    rs1451567591,2
    C,F--35205381(+) ATGGTG/ATACAG 2 -- int11Minor allele frequency- A:0.00NA 4552
    rs1439174101,2
    C--35205428(+) TTGATC/TACAGC 2 -- int10--------
    rs22329111,2
    C,F,H--35205479(+) TTGGAA/GGACCC 2 -- int14Minor allele frequency- G:0.00NS CSA WA NA 4792
    rs2001281481,2
    C--35205498(+) TGGACC/TGCGAA 2 -- int10--------
    rs1418835881,2
    C,F--35205500(+) GACCGC/TGAATC 2 -- int12Minor allele frequency- T:0.00NA EU 5873
    rs60283601,2
    C,H--35205535(+) TGCAAG/AGGTTG 2 -- int14Minor allele frequency- A:0.00NS EA 406
    rs10603201,2
    C--35205586(+) CATTTC/TTGAAT 2 -- int13Minor allele frequency- T:0.07MN NA 188
    rs1425024671,2
    C--35205744(+) AAACT-/ATCATCAA 2 -- cds10--------

    HapMap Linkage Disequilibrium report for SLA2 (35240721 - 35274619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2554197CNV Insertion19546169
    nsv833967CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606577    OMIM disorders: --

    1 disease for SLA2:    
    About MalaCards
    blastomycosis

    1 disease from the University of Copenhagen DISEASES database for SLA2:
    Blastomycosis

    Find genes that share disorders with SLA2           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SLA2 (1 document)

    Export disorders for SLA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLA2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SLA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PubMed id 11696592)1, 2, 3, 9 Holland S.J.... Wu J. (J. Exp. Med. 2001)
    2. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. (PubMed id 11891219)1, 2, 9 Pandey A.... Mann M. (J. Biol. Chem. 2002)
    3. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. (PubMed id 12527895)1, 2, 9 Loreto M.P. and McGlade C.J. (Oncogene 2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. (PubMed id 12024036)1, 9 Loreto M.P....McGlade C.J. (Mol. Cell. Biol. 2002)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. (PubMed id 21044367)1 Tatonetti N.P....Altman R.B. (BMC Bioinformatics 2010)
    10. Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling. (PubMed id 20828795)1 Sugihara S....Kimura A. (Thromb. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84174 HGNC: 17329 AceView: SLA2 Ensembl:ENSG00000101082 euGenes: HUgn84174
    ECgene: SLA2 H-InvDB: SLA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLA2 gene:
    Search GeneIP for patents involving SLA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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