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Aliases for SLA2 Gene

Aliases for SLA2 Gene

  • Src Like Adaptor 2 2 3 5
  • Modulator Of Antigen Receptor Signaling 3 4
  • C20orf156 3 4
  • SLAP-2 3 4
  • SLAP2 3 4
  • MARS 3 4
  • Src-Like Adapter Protein-2 3
  • Src-Like Adapter Protein 2 4
  • Src-Like-Adaptor 2 2
  • Src-Like-Adapter 2 3

External Ids for SLA2 Gene

Previous HGNC Symbols for SLA2 Gene

  • C20orf156

Previous GeneCards Identifiers for SLA2 Gene

  • GC20M034969
  • GC20M035879
  • GC20M035926
  • GC20M034657
  • GC20M034674
  • GC20M035240
  • GC20M031976

Summaries for SLA2 Gene

Entrez Gene Summary for SLA2 Gene

  • This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLA2 Gene

SLA2 (Src Like Adaptor 2) is a Protein Coding gene. Among its related pathways are TCR signaling in naive CD4+ T cells. GO annotations related to this gene include protein N-terminus binding and SH3/SH2 adaptor activity. An important paralog of this gene is SLA.

UniProtKB/Swiss-Prot for SLA2 Gene

  • Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Gene Wiki entry for SLA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLA2 Gene

Genomics for SLA2 Gene

Regulatory Elements for SLA2 Gene

Enhancers for SLA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F035739 2.6 FANTOM5 ENCODE 9.7 +904.5 904493 7.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CPNE1 RBM12 PHF20 AAR2 RBM39 EIF6 TRPC4AP RPL36P4 SLA2 SPAG4
GH20F036830 1.8 FANTOM5 Ensembl ENCODE 9.8 -187.6 -187640 7.5 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 FOS ZNF263 SLA2 NDRG3 BLCAP RBL1 DSN1 SOGA1 GC20P036795
GH20F035765 1.6 FANTOM5 ENCODE 9.7 +876.7 876671 9.2 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CPNE1 RBM12 NCOA6 PHF20 AAR2 TRPC4AP PROCR RPF2P1 C20orf173 HMGB3P2
GH20F036643 1.2 FANTOM5 ENCODE 12.6 +0.3 267 4.1 PKNOX1 ZFP64 ARID4B ZNF362 CEBPB MIER2 TGIF2 MIER3 SSRP1 CEBPA NDRG3 SLA2 C20orf24 RBL1 SAMHD1 TGIF2 HNRNPA3P2
GH20F036942 1.4 FANTOM5 Ensembl ENCODE 9.1 -298.1 -298104 3.1 ZNF133 RARA TEAD3 ZNF121 TRIM24 PRDM10 KLF8 ZNF639 SOX5 ZNF280D SLA2 SAMHD1 MANBAL RBL1 TGIF2 TLDC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLA2 on UCSC Golden Path with GeneCards custom track

Promoters for SLA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001837110 516 201 POLR2A

Genomic Location for SLA2 Gene

Chromosome:
20
Start:
36,612,318 bp from pter
End:
36,646,216 bp from pter
Size:
33,899 bases
Orientation:
Minus strand

Genomic View for SLA2 Gene

Genes around SLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLA2 Gene

Proteins for SLA2 Gene

  • Protein details for SLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Q3-SLAP2_HUMAN
    Recommended name:
    Src-like-adapter 2
    Protein Accession:
    Q9H6Q3
    Secondary Accessions:
    • A8K648
    • E1P5U1
    • E1P5U2
    • Q5TH27
    • Q5TH28
    • Q8WY18
    • Q96QI4
    • Q9H135

    Protein attributes for SLA2 Gene

    Size:
    261 amino acids
    Molecular mass:
    28585 Da
    Quaternary structure:
    • Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated).

    Three dimensional structures from OCA and Proteopedia for SLA2 Gene

    Alternative splice isoforms for SLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLA2 Gene

Post-translational modifications for SLA2 Gene

Other Protein References for SLA2 Gene

Antibody Products

  • Abcam antibodies for SLA2

No data available for DME Specific Peptides for SLA2 Gene

Domains & Families for SLA2 Gene

Gene Families for SLA2 Gene

Protein Domains for SLA2 Gene

Suggested Antigen Peptide Sequences for SLA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6Q3

UniProtKB/Swiss-Prot:

SLAP2_HUMAN :
  • The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression.
Domain:
  • The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with SLA2: view

Function for SLA2 Gene

Molecular function for SLA2 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Gene Ontology (GO) - Molecular Function for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IDA 11891219
GO:0005515 protein binding IPI 11891219
GO:0047485 protein N-terminus binding IPI 11891219
genes like me logo Genes that share ontologies with SLA2: view
genes like me logo Genes that share phenotypes with SLA2: view

Animal Models for SLA2 Gene

MGI Knock Outs for SLA2:

Animal Model Products

miRNA for SLA2 Gene

miRTarBase miRNAs that target SLA2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SLA2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLA2 Gene

Localization for SLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLA2 Gene

Cytoplasm.
Isoform 1: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
Isoform 2: Cytoplasm. Note=May be cytoplasmic and is not localized to membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLA2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
golgi apparatus 5
endosome 5
cytosol 3
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 11696592
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane TAS 11891219
GO:0010008 endosome membrane NAS 11696592
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLA2: view

Pathways & Interactions for SLA2 Gene

genes like me logo Genes that share pathways with SLA2: view

Pathways by source for SLA2 Gene

1 BioSystems pathway for SLA2 Gene

Gene Ontology (GO) - Biological Process for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11696592
GO:0009967 positive regulation of signal transduction IEA --
GO:0019724 B cell mediated immunity TAS 11891219
GO:0030522 intracellular receptor signaling pathway TAS 11891219
GO:0042110 T cell activation TAS 11891219
genes like me logo Genes that share ontologies with SLA2: view

No data available for SIGNOR curated interactions for SLA2 Gene

Drugs & Compounds for SLA2 Gene

(3) Drugs for SLA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLA2: view

Transcripts for SLA2 Gene

Unigene Clusters for SLA2 Gene

Src-like-adaptor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SLA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for SLA2 Gene

GeneLoc Exon Structure for
SLA2
ECgene alternative splicing isoforms for
SLA2

Expression for SLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLA2 Gene

mRNA differential expression in normal tissues according to GTEx for SLA2 Gene

This gene is overexpressed in Whole Blood (x34.2).

Protein differential expression in normal tissues from HIPED for SLA2 Gene

This gene is overexpressed in Platelet (52.9) and Peripheral blood mononuclear cells (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLA2 Gene



Protein tissue co-expression partners for SLA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLA2 Gene:

SLA2

SOURCE GeneReport for Unigene cluster for SLA2 Gene:

Hs.713578

mRNA Expression by UniProt/SwissProt for SLA2 Gene:

Q9H6Q3-SLAP2_HUMAN
Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.
genes like me logo Genes that share expression patterns with SLA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLA2 Gene

Orthologs for SLA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLA2 34 35
  • 99.23 (n)
cow
(Bos Taurus)
Mammalia SLA2 34 35
  • 88.08 (n)
dog
(Canis familiaris)
Mammalia SLA2 34 35
  • 86.03 (n)
rat
(Rattus norvegicus)
Mammalia Sla2 34
  • 81.67 (n)
mouse
(Mus musculus)
Mammalia Sla2 34 16 35
  • 81.52 (n)
oppossum
(Monodelphis domestica)
Mammalia SLA2 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLA2 34 35
  • 66.83 (n)
lizard
(Anolis carolinensis)
Reptilia SLA2 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sla2 34
  • 59.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68984 34
zebrafish
(Danio rerio)
Actinopterygii sla2 34 35
  • 57.41 (n)
Species where no ortholog for SLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLA2 Gene

ENSEMBL:
Gene Tree for SLA2 (if available)
TreeFam:
Gene Tree for SLA2 (if available)

Paralogs for SLA2 Gene

Paralogs for SLA2 Gene

(9) SIMAP similar genes for SLA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLA2: view

Variants for SLA2 Gene

Sequence variations from dbSNP and Humsavar for SLA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1060320 -- 36,612,261(+) CATTT(C/T)TGAAT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111270662 -- 36,612,281(+) ACCAA(C/T)CATTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111336116 -- 36,644,412(+) GAGAG(G/T)TGCAG intron-variant
rs111403157 -- 36,639,396(+) TCTCT(-/AC)ACACA intron-variant
rs111431205 -- 36,620,575(+) TTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLA2 Gene

Variant ID Type Subtype PubMed ID
esv2554197 CNV insertion 19546169
esv3575371 CNV gain 25503493
nsv1057192 CNV loss 25217958
nsv1119489 CNV insertion 24896259
nsv477320 CNV novel sequence insertion 20440878
nsv833967 CNV loss 17160897
nsv962575 CNV duplication 23825009

Variation tolerance for SLA2 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLA2 Gene

Disorders for SLA2 Gene

Relevant External Links for SLA2

Human Genome Epidemiology (HuGE) Navigator
SLA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLA2

No disorders were found for SLA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLA2 Gene

Publications for SLA2 Gene

  1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PMID: 11696592) Holland S.J. … Wu J. (J. Exp. Med. 2001) 2 3 4 22 64
  2. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. (PMID: 12527895) Loreto M.P. … McGlade C.J. (Oncogene 2003) 3 4 22 64
  3. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. (PMID: 11891219) Pandey A. … Mann M. (J. Biol. Chem. 2002) 3 4 22 64
  4. The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease. (PMID: 26339145) Marton N. … Nagy G. (Mediators Inflamm. 2015) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SLA2 Gene

Sources for SLA2 Gene

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