Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLA2 Gene

protein-coding   GIFtS: 56
GCID: GC20M035240

Src-Like-Adaptor 2


(Previous symbol: C20orf156)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Src-Like-Adaptor 21 2     SLAP-22 3
C20orf1561 2 3     Src-Like Adapter Protein-22
SLAP22 3 5     Src-Like-Adapter 22
Modulator Of Antigen Receptor Signaling2 3     Src-Like Adapter Protein 23
MARS2 3     

External Ids:    HGNC: 173291   Entrez Gene: 841742   Ensembl: ENSG000001010827   OMIM: 6065775   UniProtKB: Q9H6Q33   

Export aliases for SLA2 gene to outside databases

Previous GC identifers: GC20M034969 GC20M035879 GC20M035926 GC20M034657 GC20M034674 GC20M031976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLA2 Gene:
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important
receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced
calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c.
Two transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for SLA2 Gene: 
SLA2 (Src-like-adaptor 2) is a protein-coding gene. Diseases associated with SLA2 include blastomycosis, and prostatitis, and among its related super-pathways are TCR signaling in naive CD8+ T cells. GO annotations related to this gene include SH3/SH2 adaptor activity and protein N-terminus binding. An important paralog of this gene is SLA.

UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell
antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins
such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins

Gene Wiki entry for SLA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLA2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   AREB6   Pax-3   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

SLA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035240:  view genomic region     (about GC identifiers)

Start:
35,240,721 bp from pter      End:
35,274,619 bp from pter
Size:
33,899 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3 (See protein sequence)
Recommended Name: Src-like-adapter 2  
Size: 261 amino acids; 28585 Da
Subunit: Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2
domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL
(phosphorylated)
Subcellular location: Cytoplasm
Subcellular location: Isoform 1: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and
intracellular vesicles, including late endosomal vesicles
Subcellular location: Isoform 2: Cytoplasm (Probable). Note=May be cytoplasmic and is not localized to membranes
Secondary accessions: A8K648 E1P5U1 E1P5U2 Q5TH27 Q5TH28 Q8WY18 Q96QI4 Q9H135
Alternative splicing, Alternative initiation: 4 isoforms:  Q9H6Q3-1   Q9H6Q3-2   Q9H6Q3-3   Q9H6Q3-4   (Produced by alternative initiation at Met-28 of isoform 2)

Explore the universe of human proteins at neXtProt for SLA2: NX_Q9H6Q3

Explore proteomics data for SLA2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CSF1R (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H6Q3

  • SLA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLA2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_115590.1  NP_778252.1  

    ENSEMBL proteins: 
     ENSP00000262866   ENSP00000353890  

    Human Recombinant Protein Products for SLA2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLA2
    OriGene Protein Over-expression Lysate for SLA2
    OriGene MassSpec for SLA2 
    OriGene Custom Protein Services for SLA2
    GenScript Custom Purified and Recombinant Proteins Services for SLA2
    Novus Biologicals SLA2 Proteins
    Novus Biologicals SLA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLA2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS11696592
    GO:0005770late endosome IEA--
    GO:0005886plasma membrane TAS11891219
    GO:0010008endosome membrane NAS11696592
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    SLA2 for ontologies           About GeneDecksing



    SLA2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLA2
    OriGene Custom Antibody Services for SLA2
    GenScript Custom Superior Antibodies Services for SLA2
    Novus Biologicals SLA2 Antibodies
    Abcam antibodies for SLA2
    Cloud-Clone Corp. Antibodies for SLA2 
    Search ThermoFisher Antibodies for SLA2
    LSBio Antibodies in human, mouse, rat for SLA2 

    Assay Products for SLA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLA2 
    Cloud-Clone Corp. CLIAs for SLA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9H6Q3

    ProtoNet protein and cluster: Q9H6Q3

    2 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
    Domain: The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially
    compensated by higher level of protein expression
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    SLA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAP2_HUMAN, Q9H6Q3
    Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell
    antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins
    such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IDA11891219
    GO:0005515protein binding IPI11891219
    GO:0047485protein N-terminus binding IPI11891219
         
    SLA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLA2:
     Decreased Salmonella enterica   Decreased nuclei size in G2M 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sla2):
     cellular  hematopoietic system  immune system 

    SLA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sla2tm1Amch for SLA2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLA2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLA2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SLA2 (see all 16):
    hsa-miR-623 hsa-miR-328 hsa-miR-1260b hsa-miR-204 hsa-miR-589 hsa-miR-761 hsa-miR-4306 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidSLA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLA2
    Sirion Biotech Customized adenovirus for overexpression of SLA2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLA2 (see all 13)
    OriGene ORF clones in mouse, rat for SLA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLA2 (NM_032214)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA2
    Sirion Biotech Customized lentivirus for stable overexpression of SLA2 
                         Customized lentivirus expression plasmids for stable overexpression of SLA2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLA2
    Search LifeMap BioReagents cell lines for SLA2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    2B Cell Receptor Signaling Pathway
    B Cell Receptor Signaling Pathway


    2 BioSystems Pathways for SLA2
        B Cell Receptor Signaling Pathway
    TCR signaling in naive CD4+ T cells


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/16 Interacting proteins for SLA2 (Q9H6Q32, 3 ENSP000002628664) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74748 MINT-74749 I2D: score=2 STRING: ENSP00000269571
    CD247P209633, ENSP000003547824I2D: score=2 STRING: ENSP00000354782
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    LAMC2Q137533, ENSP000002641444I2D: score=1 STRING: ENSP00000264144
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11696592
    GO:0019724B cell mediated immunity TAS11891219
    GO:0030522intracellular receptor signaling pathway TAS11891219
    GO:0042110T cell activation TAS11891219
    GO:0050776regulation of immune response NAS11696592

    SLA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLA2 (SLAP2)

    3 Novoseek inferred chemical compound relationships for SLA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ionomycin 60.5 1 11696592 (1)
    tyrosine 33.8 5 12024036 (2), 11696592 (2), 11891219 (1)
    calcium 8.92 1 11696592 (1)

    Search CenterWatch for drugs/clinical trials and news about SLA2 / SLAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLA2 gene (2 alternative transcripts): 
    NM_032214.3  NM_175077.2  

    Unigene Cluster for SLA2:

    Src-like-adaptor 2
    Hs.713578  [show with all ESTs]
    Unigene Representative Sequence: NM_032214
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262866(uc002xfu.3 uc002xfv.3) ENST00000360672
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLA2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SLA2 (see all 16):
    hsa-miR-623 hsa-miR-328 hsa-miR-1260b hsa-miR-204 hsa-miR-589 hsa-miR-761 hsa-miR-4306 hsa-miR-1267
    SwitchGear 3'UTR luciferase reporter plasmidSLA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLA2
    Clone
    Products:
         
    OriGene clones in human, mouse for SLA2 (see all 13)
    OriGene ORF clones in mouse, rat for SLA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLA2 (NM_032214)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA2
    Sirion Biotech Customized lentivirus for stable overexpression of SLA2 
                         Customized lentivirus expression plasmids for stable overexpression of SLA2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLA2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLA2

    Additional mRNA sequence: 

    AF290985.1 AF290986.1 AF326353.1 AK025645.1 AK291513.1 BC042041.1 

    6 DOTS entries:

    DT.100820465  DT.436670  DT.95157974  DT.100820460  DT.100820463  DT.95157975 

    24/45 AceView cDNA sequences (see all 45):

    NM_032214 AL541041 BC042041 NM_175077 AL844325 AW366977 AI476149 AI002059 
    BQ054265 AI476150 AF326353 AF290985 BQ052468 AW366963 BG677567 BU944126 
    AA305476 AF290986 AA310216 BF059756 AK025645 AA309769 AL844307 BG178487 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLA2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                                                        
    SP2:                                            -                           
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for SLA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTTCACC
    SLA2 Expression
    About this image


    See SLA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLA2

    SOURCE GeneReport for Unigene cluster: Hs.713578

    UniProtKB/Swiss-Prot: SLAP2_HUMAN, Q9H6Q3
    Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes.
    Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in
    B-cells. Also detected in placenta, prostate, skin, retina and colon

        SABiosciences Custom PCR Arrays for SLA2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLA2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLA2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLA2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLA2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sla21 , 5 Src-like-adaptor 21, 5 83.59(n)1
    81.01(a)1
      2 (77.89 cM)5
    777991  NM_029983.51  NP_084259.11 
     1568724575 
    chicken
    (Gallus gallus)
    Aves LOC1008587501 src-like-adapter 2-like 62.63(n)
    55.65(a)
      100858750  XM_003642446.1  XP_003642494.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLA26
    Uncharacterized protein
    45(a)
    1 ↔ 1
    4(134678505-134687916)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689842 hypothetical protein MGC68984 71.16(n)    BC056035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sla21 Src-like-adaptor 2 57.64(n)
    44.62(a)
      568515  NM_001114435.1  NP_001107907.1 


    ENSEMBL Gene Tree for SLA2 (if available)
    TreeFam Gene Tree for SLA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLA2 gene
    SLA2  
    9 SIMAP similar genes for SLA2 using alignment to 1 protein entry:     SLAP2_HUMAN:
    LCK    BLK    HCK    FYN    FGR    LYN
    SLA    YES1    SRC

    SLA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/851 SNPs in SLA2 are shown (see all 851)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907420831,2
    Cuntested135205447(+) TTGATC/TGTTGG 2 -- ds50010--------
    rs1382442401,2
    C--35205345(+) TTGGAC/TCATCT 2 -- int10--------
    rs1451567591,2
    C,F--35205381(+) ATGGTG/ATACAG 2 -- int11Minor allele frequency- A:0.00NA 4552
    rs1439174101,2
    C--35205428(+) TTGATC/TACAGC 2 -- int10--------
    rs22329111,2
    C,F,H--35205479(+) TTGGAA/GGACCC 2 -- int14Minor allele frequency- G:0.00NS CSA WA NA 4792
    rs2001281481,2
    C--35205498(+) TGGACC/TGCGAA 2 -- int10--------
    rs1418835881,2
    C,F--35205500(+) GACCGC/TGAATC 2 -- int12Minor allele frequency- T:0.00NA EU 5873
    rs60283601,2
    C,H--35205535(+) TGCAAG/AGGTTG 2 -- int14Minor allele frequency- A:0.00NS EA 406
    rs10603201,2
    C--35205586(+) CATTTC/TTGAAT 2 -- int13Minor allele frequency- T:0.07MN NA 188
    rs1425024671,2
    C--35205744(+) AAACT-/ATCATCAA 2 -- cds10--------

    HapMap Linkage Disequilibrium report for SLA2 (35240721 - 35274619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2554197CNV Insertion19546169
    nsv833967CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLA2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606577    OMIM disorders: --

    2 diseases for SLA2:    About MalaCards
    blastomycosis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLA2:
    Blastomycosis

    SLA2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: SLA2 (1 document)

    Export disorders for SLA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLA2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SLA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PubMed id 11696592)1, 2, 3, 9 Holland S.J.... Wu J. (2001)
    2. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. (PubMed id 11891219)1, 2, 9 Pandey A.... Mann M. (2002)
    3. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. (PubMed id 12527895)1, 2, 9 Loreto M.P. and McGlade C.J. (2003)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. (PubMed id 12024036)1, 9 Loreto M.P....McGlade C.J. (2002)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. An integrative method for scoring candidate genes fro m association studies: application to warfarin dosing. (PubMed id 21044367)1 Tatonetti N.P....Altman R.B. (2010)
    10. Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI- mediated platelet activation SLAP-2 and GPVI signaling. (PubMed id 20828795)1 Sugihara S....Kimura A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84174 HGNC: 17329 AceView: SLA2 Ensembl:ENSG00000101082 euGenes: HUgn84174
    ECgene: SLA2 H-InvDB: SLA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLA2 gene:
    Search GeneIP for patents involving SLA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLA2   OriGene RNAi products in human, mouse, rat for SLA2  
     OriGene qPCR primer pairs and template standards for SLA2   OriGene Protein Over-expression Lysate for SLA2  
     OriGene MassSpec something-or-other for SLA2   OriGene clones in human, mouse for SLA2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLA2   OriGene Purified Protein for SLA2  
     OriGene ORF clones in mouse, rat for SLA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLA2   OriGene Custom Protein Services for SLA2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLA2
     QIAGEN SeqTarget long-range PCR primers for resequencing SLA2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLA2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLA2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLA2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLA2
     GenScript Custom Purified and Recombinant Proteins Services for SLA2 GenScript cDNA clones with any tag delivered in your preferred vector for SLA2
     GenScript Custom Assay Services for SLA2 GenScript Custom Superior Antibodies Services for SLA2
     GenScript Custom overexpressing Cell Line Services for SLA2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLA2 promoter
     Search Chromatin IP Primers for SLA2
     RT2 qPCR Primer Assay in human, mouse, rat SLA2
     GNC Network for SLA2
     SABiosciences Custom PCR Arrays for SLA2
     Search Tocris compounds for SLA2 (SLAP2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLA2 antibodies
     SLA2 proteins
     SLA2 lysates
     Antibodies for SLA2
     See all of Abcam's Antibodies, Kits and Proteins for SLA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLA2
     Antibodies for SLA2
     ELISAs for SLA2
     CLIAs for SLA2
     Search LifeMap BioReagents cell lines for SLA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA2
     SwitchGear 3'UTR luciferase reporter plasmids for SLA2
     SwitchGear Promoter luciferase reporter plasmids for SLA2
     Search ThermoFisher Antibodies for SLA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLA2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLA2
    Customized:
     lentivirus for stable overexpression of SLA2
     lentivirus expression plasmids for stable overexpression of SLA2
     adenovirus for overexpression of SLA2
     LSBio Antibodies in human, mouse, rat for SLA2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLA2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4