Aliases for SLA Gene
External Ids for SLA Gene
GeneCards Summary for SLA Gene
SLA (Src-Like-Adaptor) is a Protein Coding gene. Diseases associated with SLA include pontocerebellar hypoplasia type 2d. Among its related pathways are PDGFR-beta signaling pathway and EPHB forward signaling. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SLA2.
UniProtKB/Swiss-Prot for SLA Gene
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.