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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLA Gene

protein-coding   GIFtS: 56
GCID: GC08M134118

Src-like-adaptor

(Previous name: Src-like-adapter )
 Explore 3 diseases affiliated with
SLA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLA    

Aliases
for SLA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Src-Like-Adaptor1     HSLAP1
SLA11 2     Src-Like-Adapter1
Src-Like-Adapter Protein 12 3     Src-Like-Adapter1
SLAP2 3     SLAP13
SLAP-12 3     

External Ids:    HGNC: 109021   Entrez Gene: 65032   Ensembl: ENSG000001559267   OMIM: 6010995   UniProtKB: Q132393   

Export aliases for SLA gene to outside databases

Previous GC identifers: GC08M132778 GC08M134136 GC08M133719 GC08M134005 GC08M129368


Summaries
for SLA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor
induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection
and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent
degradation of signaling proteins




Genomic Views
for SLA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLA gene promoter:
         USF1   AML1a   POU6F1 (c2)   IRF-1   E47   AREB6   POU2F1   POU2F1a   USF-1   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLA promoter sequence
   Search SABiosciences Chromatin IP Primers for SLA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q22.3-qter

SLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M134118:  view genomic region     (about GC identifiers)

Start:
 134,048,973 bp from pter      End:
 134,115,310 bp from pter
Size:
 66,338 bases      Orientation:
 minus strand

Proteins
for SLA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239 (See protein sequence)
Recommended Name: Src-like-adapter  
Size: 276 amino acids; 31156 Da
Subunit: Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with
phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT
via its SH2 domain
Subcellular location: Cytoplasm (By similarity). Endosome (By similarity). Note=Colocalizes with endosomes (By
similarity)
1 PDB 3D structure from and Proteopedia for SLA:
2CUD (3D)    
Secondary accessions: Q9UMQ8

Explore the universe of human proteins at neXtProt for SLA: NX_Q13239

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13239

    • SLA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001039021.1  NP_001039022.2  NP_006739.2  

    ENSEMBL proteins: 
     ENSP00000337548   ENSP00000394049   ENSP00000378759   ENSP00000427928   ENSP00000428559  
     ENSP00000430596   ENSP00000429681   ENSP00000429844   ENSP00000430184   ENSP00000428087  
     ENSP00000428971   ENSP00000429143  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SLA
    OriGene Custom Protein Services for SLA 
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    Novus Biologicals SLA Proteins
    Novus Biologicals SLA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLA

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--


    SLA for ontologies           About GeneDecksing



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    Uscn Antibodies for SLA
    ThermoFisher Antibodies for SLA

    Assay Products for SLA: 
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    Uscn ELISAs and CLIAs for SLA

    Protein Domains /
    Families
    for SLA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000980 SH2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q13239

    ProtoNet protein and cluster: Q13239

    1 Blocks protein family: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
    Domain: The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction
    with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently
    required for the homodimerization
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for SLA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
    Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor
    induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection
    and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent
    degradation of signaling proteins
    Induction: By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins

         Genatlas biochemistry entry for SLA:
    mouse Src-like adaptor protein (Slap) homolog,binding the Eck receptor protein tyrosine kinase,involved in signal
    transduction

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SLA (see all 20):
    hsa-miR-4254 hsa-miR-181c hsa-miR-1260b hsa-miR-578 hsa-miR-2115 hsa-miR-383 hsa-miR-155 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: SLA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLA (see all 7)
    OriGene shRNA RFP: SLA
    OriGene siRNA: SLA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLA

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS7543898


    SLA for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Slatm1Weis for SLA
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sla):
     cellular  hematopoietic system  immune system 

    SLA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Ephrins signaling
    		Cell adhesion_Ephrins signaling1.00
    		Cell adhesion Ephrins signaling1.00
    2PDGFR-beta signaling pathway
    		PDGFR-beta signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLA
        Cell adhesion Ephrins signaling


    1 GeneGo (Thomson Reuters) Pathway for SLA
        Cell adhesion Ephrins signaling

    1 BioSystems Pathway for SLA 
        PDGFR-beta signaling pathway



    SLA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for SLA (Q132392, 3 ENSP000003940494) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFRBP096192, 3, ENSP000002617994MINT-8038085 MINT-8026898 MINT-8026913 MINT-8038100 I2D: score=1 STRING: ENSP00000261799
    ERBB2P046262, 3, ENSP000002695714MINT-74747 I2D: score=1 STRING: ENSP00000269571
    PAFAH1B2P684022, 3MINT-64002 I2D: score=3 
    GSK3BP498412, 3MINT-8257702 I2D: score=2 
    EGFRP005332, 3, ENSP000002754934MINT-74746 I2D: score=1 STRING: ENSP00000275493
    About this table

    Drugs & Compounds
    for SLA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLA
    2 Novoseek chemical compound relationships for SLA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 38.4 6 9020066 (3), 11179692 (1)
    tyrosine 37.2 8 16887961 (2), 8825655 (2), 11179692 (1)

    Search CenterWatch for drugs/clinical trials and news about SLA / SLAP1 

    Transcripts
    for SLA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLA gene (3 alternative transcripts): 
    NM_001045556.2  NM_001045557.2  NM_006748.3  

    Unigene Cluster for SLA:

    Src-like-adaptor
    Hs.75367  [show with all ESTs]
    Unigene Representative Sequence: BX647569
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000338087(uc011ljd.2 uc003ytz.3 uc011lje.2 uc011ljf.2 uc011ljg.2)
    ENST00000427060 ENST00000395352 ENST00000517549 ENST00000524345 ENST00000517648
    ENST00000522119 ENST00000523224(uc010mdy.1) ENST00000521823 ENST00000519341
    ENST00000522002(uc010mdz.1) ENST00000518565(uc010mea.2) ENST00000520106
    ENST00000522432 ENST00000519504 ENST00000518594 ENST00000521302 ENST00000523610


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLA
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SLA (see all 20):
    hsa-miR-4254 hsa-miR-181c hsa-miR-1260b hsa-miR-578 hsa-miR-2115 hsa-miR-383 hsa-miR-155 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: SLA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLA (see all 7)
    OriGene shRNA RFP: SLA
    OriGene siRNA: SLA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLA
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): SLA (NM_001045556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLA

    Additional cDNA sequence: 

    AJ238591.1 AK297423.1 AK297519.1 AK309401.1 AK310092.1 AK310108.1 AK310115.1 AK311010.1 
    AK312584.1 BC007042.1 BT019994.1 BX647569.1 BX648382.1 CR536537.1 D89077.1 U30473.1 
    U44403.1 

    24/25 DOTS entries (see all 25):

    DT.75102889  DT.100745672  DT.445563  DT.97816119  DT.92425755  DT.100745673  DT.120642389  DT.120642420 
    DT.120642281  DT.120642349  DT.120642470  DT.120642338  DT.120642459  DT.100000459  DT.100745674  DT.120642180 
    DT.120642235  DT.120642249  DT.120642494  DT.40226559  DT.75151691  DT.95081040  DT.95128762  DT.99965233 

    24/185 AceView cDNA sequences (see all 185):

    CR617843 AA486660 Z38323 BQ709240 AI239511 R58897 AI696144 CR601997 
    CR617946 AA651886 BX436824 AL548133 BE676541 BQ184724 U44403 AA310113 
    BC007042 CB155263 BX383094 T33710 BM975355 AI815620 C01387 CD365707 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLA (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
    SP1:                                                  -           -                       -     -     -                 -                                       
    SP2:              -     -     -     -     -     -     -           -                       -     -     -                 -                                       
    SP3:              -     -     -     -     -     -     -           -                       -                                                                     
    SP4:                                                  -                                                                                                         
    SP5:                                            -     -           -                       -     -     -                                                         


    ECgene alternative splicing isoforms for SLA

    Expression
    for SLA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLA

    SOURCE GeneReport for Unigene cluster: Hs.75367

    UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
    Tissue specificity: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver,
    skeletal muscle, kidney and pancreas

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA

    Orthologs
    for SLA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLA gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLA1 Src-like-adaptor 67.27(n)
    68.84(a)    		   378908  NM_204391.1  NP_989722.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLA6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 4(750482-762914)
    zebrafish
    (Danio rerio)    		 Actinopterygii sla11 Src-like-adaptor 1 60.09(n)
    55.79(a)    		   571922  NM_001034989.1  NP_001030161.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G469206
    AT5G576106
    (see all 7)    		 octicosapeptide/Phox/Bem1p domain-containing prote...
    octicosapeptide/Phox/Bem1p domain-containing prote...
    (see all 7)    		 3(a)
    3(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 3(17280430-17284857)
    5(23324791-23329347)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 3(a)
    3(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 3(16281357-16289129)
    6(26398279-26404234)


    ENSEMBL Gene Tree for SLA (if available)
    TreeFam Gene Tree for SLA (if available) 

    Paralogs
    for SLA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLA gene
    SLA22  
    11 SIMAP similar genes for SLA using alignment to 11 protein entries:     SLAP1_HUMAN (see all proteins):
    GRAP2    BLK    HCK    FYN    SLA2    GRAPL
    LYN    YES1    LCK    SRC    FGR

    SLA for paralogs           About GeneDecksing



    Genomic Variants
    for SLA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1448 NCBI SNPs in SLA are shown (see all 1448)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10495351,2
    		C--129368915(-) GATGTC/TTGCAC 1 -- int1 ese32Minor allele frequency- T:0.00NA 4
    rs562296081,2
    		C,F,--129368960(+) AGTCAA/GTGTCC 1 -- int11Minor allele frequency- G:0.08NA 120
    rs101060751,2
    		C,F,A,H,--129369663(+) ACTTAC/TGCATC 1 -- int1 ese320Minor allele frequency- T:0.13NS EA NA CSA WA 2549
    rs787046031,2
    		C,F,--129369726(+) CTATTC/TGGGCA 1 -- int11Minor allele frequency- T:0.02WA 118
    rs64711101,2
    		C,F,A,H,--129369983(+) TGAAGG/TCTAAG 1 -- int111Minor allele frequency- T:0.01NS EA NA WA 1250
    rs614015471,2
    		C,--129370130(+) CAGCTT/GTTGTT 1 -- int12Minor allele frequency- G:0.07WA 120
    rs10495291,2
    		--129370340(-) ATCACA/GAAACA 1 -- int1 ese30--------
    rs597004531,2
    		C,--129370452(+) AATACG/ATGAGG 1 -- int12Minor allele frequency- A:0.05WA 120
    rs608291381,2
    		C,--129371046(+) GGGATC/TACAAC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs559873151,2
    		C,F,--129371752(+) AGAATG/ATATAT 1 -- int14Minor allele frequency- A:0.09WA NA 242

    HapMap Linkage Disequilibrium report for SLA (134048973 - 134115310 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLA
         2 CNVs: 7669 0123

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLA
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    Disorders / Diseases
    for SLA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLA for disorders           About GeneDecksing

    OMIM gene information: 601099    OMIM disorders: --

    3 diseases for SLA:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: SLA (7 documents)

    Export disorders for SLA gene to outside databases

    Publications
    for SLA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLA gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SLA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. (PubMed id 8825655)1, 2, 3, 9 Angrist M.... Pandey A. (1995)
    2. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. (PubMed id 11179692)1, 2, 3, 9 Kratchmarova I....Pandey A. (2001)
    3. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. (PubMed id 9020066)1, 2, 9 Ohtsuki T....Miura Y. (1997)
    4. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PubMed id 11696592)1, 2, 9 Holland S.J.... Wu J. (2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. (PubMed id 10449770)1, 2 Tang J.... Burakoff S.J. (1999)
    7. The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene. (PubMed id 9660183)1, 2 Meijerink P.H.S.... Baas F. (1998)
    8. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. (PubMed id 10662792)1, 9 Sosinowski T....Weiss A. (2000)
    9. Genome-wide association analyses identify 13 new susce ptibility loci for generalized vitiligo. (PubMed id 22561518)1 Jin Y....Spritz R.A. (2012)
    10. CD3z-chain expression of human T lymphocytes is regula ted by TNF via Src-like adaptor protein-dependent proteasomal degradation. (PubMed id 22798681)1 Ersek B....Nagy G. (2012)

    External Searches for SLA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
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    Genome Databases showing SLA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6503 HGNC: 10902 AceView: SLA Ensembl:ENSG00000155926 euGenes: HUgn6503
    ECgene: SLA H-InvDB: SLA

    Other Databases showing SLA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLA gene:
    Search GeneIP for patents involving SLA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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