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Aliases for SLA Gene

Aliases for SLA Gene

  • Src Like Adaptor 2 3 5
  • Src-Like-Adapter Protein 1 3 4
  • Src-Like-Adapter 2 3
  • SLAP-1 3 4
  • HSLAP 3 4
  • SLAP 3 4
  • Src-Like-Adaptor 2
  • SLAP1 4
  • SLA1 3

External Ids for SLA Gene

Previous GeneCards Identifiers for SLA Gene

  • GC08M132778
  • GC08M134136
  • GC08M133719
  • GC08M134005
  • GC08M134118
  • GC08M129368
  • GC08M134048

Summaries for SLA Gene

GeneCards Summary for SLA Gene

SLA (Src Like Adaptor) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and EPH-Ephrin signaling. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SLA2.

UniProtKB/Swiss-Prot for SLA Gene

  • Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLA Gene

Genomics for SLA Gene

Regulatory Elements for SLA Gene

Enhancers for SLA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G133048 1.2 Ensembl ENCODE dbSUPER 22.5 +52.9 52918 2.3 NFIB JUN MAX CEBPG FOSL1 GTF3C2 PRDM10 FOS TCF7L2 SMARCC1 SLA ENSG00000223697 WISP1 MIR7848 GC08P133054
GH08G133051 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.3 +38.4 38372 25.8 CTCF PKNOX1 ZNF146 MAX RAD21 GATA3 POLR2A FOS MAFK RFX1 TG WISP1 SLA TMEM71 PHF20L1 ENSG00000270137 GC08P133054 GC08P133070
GH08G133080 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14 +20.9 20913 3.2 CTCF ZFP64 ZNF140 CEBPG RAD21 ZNF697 ZNF433 ZBTB11 CEBPB ZNF426 TMEM71 PHF20L1 WISP1 SLA ST3GAL1 TG GC08P133070
GH08G133138 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -36.3 -36317 2.4 ESRRA HLF CEBPB HMG20A CEBPG RARA CTBP1 GATA3 GATA2 CEBPA SLA WISP1 ST3GAL1 TMEM71 PHF20L1 LOC105375769 GC08P133116
GH08G133128 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -26.8 -26843 3.4 ELF3 ZNF792 CEBPG RAD21 ZNF644 HBP1 FOS ZNF652 HOMEZ THAP11 WISP1 TG SLA ST3GAL1 PHF20L1 NDRG1 GC08P133116 LOC105375769
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLA on UCSC Golden Path with GeneCards custom track

Genomic Location for SLA Gene

Chromosome:
8
Start:
133,036,724 bp from pter
End:
133,103,066 bp from pter
Size:
66,343 bases
Orientation:
Minus strand

Genomic View for SLA Gene

Genes around SLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLA Gene

Proteins for SLA Gene

  • Protein details for SLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13239-SLAP1_HUMAN
    Recommended name:
    Src-like-adapter
    Protein Accession:
    Q13239
    Secondary Accessions:
    • B7Z4J2
    • B7Z4L6
    • Q6FI01
    • Q9UMQ8

    Protein attributes for SLA Gene

    Size:
    276 amino acids
    Molecular mass:
    31156 Da
    Quaternary structure:
    • Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.
    SequenceCaution:
    • Sequence=AAH07042.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLA Gene

    Alternative splice isoforms for SLA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLA Gene

Post-translational modifications for SLA Gene

  • Ubiquitination at isoforms=3, 4, 560, Lys93, Lys104, isoforms=2, 3, 5117, Lys252, and Lys264
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLA Gene

Domains & Families for SLA Gene

Gene Families for SLA Gene

Protein Domains for SLA Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q13239

UniProtKB/Swiss-Prot:

SLAP1_HUMAN :
  • The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
Domain:
  • The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
genes like me logo Genes that share domains with SLA: view

Function for SLA Gene

Molecular function for SLA Gene

GENATLAS Biochemistry:
mouse Src-like adaptor protein (Slap) homolog,binding the Eck receptor protein tyrosine kinase,involved in signal transduction
UniProtKB/Swiss-Prot Function:
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.

Gene Ontology (GO) - Molecular Function for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA --
GO:0005070 SH3/SH2 adaptor activity IEA,TAS --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 9742401
genes like me logo Genes that share ontologies with SLA: view
genes like me logo Genes that share phenotypes with SLA: view

Animal Models for SLA Gene

MGI Knock Outs for SLA:

Animal Model Products

miRNA for SLA Gene

miRTarBase miRNAs that target SLA

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLA Gene

Localization for SLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLA Gene

Cytoplasm. Endosome. Note=Colocalizes with endosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLA gene
Compartment Confidence
plasma membrane 4
cytosol 3
endosome 3
mitochondrion 2
nucleus 2
extracellular 1
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with SLA: view

Pathways & Interactions for SLA Gene

genes like me logo Genes that share pathways with SLA: view

Pathways by source for SLA Gene

1 Sino Biological pathway for SLA Gene
1 BioSystems pathway for SLA Gene
1 GeneGo (Thomson Reuters) pathway for SLA Gene

Gene Ontology (GO) - Biological Process for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0016477 cell migration IBA --
GO:0030154 cell differentiation IBA --
GO:0038083 peptidyl-tyrosine autophosphorylation IBA --
genes like me logo Genes that share ontologies with SLA: view

No data available for SIGNOR curated interactions for SLA Gene

Drugs & Compounds for SLA Gene

(2) Drugs for SLA Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vaccines Pharma 6611

(1) Additional Compounds for SLA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLA: view

Transcripts for SLA Gene

Unigene Clusters for SLA Gene

Src-like-adaptor:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLA Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - -
SP9: - -

Relevant External Links for SLA Gene

GeneLoc Exon Structure for
SLA
ECgene alternative splicing isoforms for
SLA

Expression for SLA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLA Gene

This gene is overexpressed in Whole Blood (x28.9) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for SLA Gene

This gene is overexpressed in CD8 Tcells (41.9) and Monocytes (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLA Gene



Protein tissue co-expression partners for SLA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLA Gene:

SLA

SOURCE GeneReport for Unigene cluster for SLA Gene:

Hs.75367

mRNA Expression by UniProt/SwissProt for SLA Gene:

Q13239-SLAP1_HUMAN
Tissue specificity: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for SLA Gene

  • Nervous system(5)
  • Blood(4.7)
  • Bone marrow(4.4)
  • Liver(4.2)
  • Intestine(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SLA: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLA Gene

Orthologs for SLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLA 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia SLA 34 35
  • 86.23 (n)
dog
(Canis familiaris)
Mammalia SLA 34 35
  • 84.13 (n)
rat
(Rattus norvegicus)
Mammalia Sla 34
  • 81.54 (n)
oppossum
(Monodelphis domestica)
Mammalia SLA 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sla 34 16 35
  • 80.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLA 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLA 34 35
  • 67.27 (n)
lizard
(Anolis carolinensis)
Reptilia SLA 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sla 34
  • 65.87 (n)
zebrafish
(Danio rerio)
Actinopterygii sla1 34 35
  • 57.65 (n)
Species where no ortholog for SLA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLA Gene

ENSEMBL:
Gene Tree for SLA (if available)
TreeFam:
Gene Tree for SLA (if available)

Paralogs for SLA Gene

Paralogs for SLA Gene

genes like me logo Genes that share paralogs with SLA: view

Variants for SLA Gene

Sequence variations from dbSNP and Humsavar for SLA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2069568 Likely benign 133,096,209(+) AGCTC(C/T)TGGCC intron-variant, reference, synonymous-codon
rs73354644 Likely benign 133,095,068(+) CGGCC(A/G/T)CCGTC intron-variant, reference, missense
rs114539802 Uncertain significance 133,096,340(+) CAGGA(C/T)GACGG intron-variant, reference, synonymous-codon
rs2069569 Benign 133,096,302(+) CTTTA(C/T)GGGTA intron-variant, reference, missense
rs1000116559 -- 133,039,572(+) TTCTC(G/T)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLA Gene

Variant ID Type Subtype PubMed ID
esv33548 CNV gain 17666407
esv3573001 CNV loss 25503493
esv3573002 CNV loss 25503493
nsv465818 CNV loss 19166990
nsv482993 CNV loss 15286789
nsv525105 CNV loss 19592680
nsv612328 CNV loss 21841781
nsv6402 CNV insertion 18451855
nsv949988 CNV duplication 24416366

Variation tolerance for SLA Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLA Gene

Disorders for SLA Gene

Relevant External Links for SLA

Genetic Association Database (GAD)
SLA
Human Genome Epidemiology (HuGE) Navigator
SLA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLA

No disorders were found for SLA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLA Gene

Publications for SLA Gene

  1. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. (PMID: 11179692) Kratchmarova I. … Pandey A. (Gene 2001) 2 3 4 22 64
  2. Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. (PMID: 8825655) Angrist M. … Pandey A. (Genomics 1995) 2 3 4 22 64
  3. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PMID: 11696592) Holland S.J. … Wu J. (J. Exp. Med. 2001) 3 4 22 64
  4. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. (PMID: 9020066) Ohtsuki T. … Miura Y. (Biochem. Biophys. Res. Commun. 1997) 3 4 22 64
  5. The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease. (PMID: 26339145) Marton N. … Nagy G. (Mediators Inflamm. 2015) 2 3 64

Products for SLA Gene

  • Addgene plasmids for SLA

Sources for SLA Gene

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