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Aliases for SLA Gene

Aliases for SLA Gene

  • Src-Like-Adaptor 2 3
  • Src-Like-Adapter Protein 1 3 4
  • Src-Like-Adapter 2 3
  • SLAP-1 3 4
  • HSLAP 3 4
  • SLAP 3 4
  • SLAP1 4
  • SLA1 3

External Ids for SLA Gene

Summaries for SLA Gene

GeneCards Summary for SLA Gene

SLA (Src-Like-Adaptor) is a Protein Coding gene. Diseases associated with SLA include pontocerebellar hypoplasia type 2d. Among its related pathways are PDGFR-beta signaling pathway and EPHB forward signaling. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SLA2.

UniProtKB/Swiss-Prot for SLA Gene

  • Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLA Gene

Genomics for SLA Gene

Genomic Location for SLA Gene

Start:
133,036,724 bp from pter
End:
133,103,066 bp from pter
Size:
66,343 bases
Orientation:
Minus strand

Genomic View for SLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLA Gene

Regulatory Elements for SLA Gene

Proteins for SLA Gene

  • Protein details for SLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13239-SLAP1_HUMAN
    Recommended name:
    Src-like-adapter
    Protein Accession:
    Q13239
    Secondary Accessions:
    • B7Z4J2
    • B7Z4L6
    • Q6FI01
    • Q9UMQ8

    Protein attributes for SLA Gene

    Size:
    276 amino acids
    Molecular mass:
    31156 Da
    Quaternary structure:
    • Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.
    SequenceCaution:
    • Sequence=AAH07042.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG35478.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLA Gene

    Alternative splice isoforms for SLA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLA Gene

Proteomics data for SLA Gene at MOPED

Post-translational modifications for SLA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys60, Lys93, Lys104, Lys117, Lys252, and Lys264

No data available for DME Specific Peptides for SLA Gene

Domains for SLA Gene

Gene Families for SLA Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for SLA Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SLAP1_HUMAN
Domain:
  • The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization:
    • Q13239
  • Contains 1 SH2 domain.:
    • Q13239
  • Contains 1 SH3 domain.:
    • Q13239
genes like me logo Genes that share domains with SLA: view

Function for SLA Gene

Molecular function for SLA Gene

GENATLAS Biochemistry: mouse Src-like adaptor protein (Slap) homolog,binding the Eck receptor protein tyrosine kinase,involved in signal transduction
UniProtKB/Swiss-Prot Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
UniProtKB/Swiss-Prot Induction: By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.

Gene Ontology (GO) - Molecular Function for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 7543898
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with SLA: view
genes like me logo Genes that share phenotypes with SLA: view

Animal Models for SLA Gene

MGI Knock Outs for SLA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLA Gene

Localization for SLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLA Gene

Cytoplasm. Endosome. Note=Colocalizes with endosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLA Gene COMPARTMENTS Subcellular localization image for SLA gene
Compartment Confidence
cytosol 3
endosome 2
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with SLA: view

Pathways for SLA Gene

genes like me logo Genes that share pathways with SLA: view

Pathways by source for SLA Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for SLA Gene
1 BioSystems pathway for SLA Gene

Gene Ontology (GO) - Biological Process for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009967 positive regulation of signal transduction TAS 7543898
genes like me logo Genes that share ontologies with SLA: view

Compounds for SLA Gene

(2) Novoseek inferred chemical compound relationships for SLA Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 38.4 4
tyrosine 37.2 5
genes like me logo Genes that share compounds with SLA: view

Transcripts for SLA Gene

Unigene Clusters for SLA Gene

Src-like-adaptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLA Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - -
SP9: - -

Relevant External Links for SLA Gene

GeneLoc Exon Structure for
SLA
ECgene alternative splicing isoforms for
SLA

Expression for SLA Gene

mRNA expression in normal human tissues for SLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLA Gene

This gene is overexpressed in Whole Blood (28.9) and Spleen (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLA Gene

SOURCE GeneReport for Unigene cluster for SLA Gene Hs.75367

mRNA Expression by UniProt/SwissProt for SLA Gene

Q13239-SLAP1_HUMAN
Tissue specificity: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with SLA: view

Orthologs for SLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLA 36
  • 99.47 (n)
  • 99.68 (a)
SLA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLA 36
  • 86.23 (n)
  • 91.3 (a)
SLA 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLA 36
  • 84.13 (n)
  • 87.62 (a)
SLA 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sla 36
  • 80.94 (n)
  • 86.32 (a)
Sla 16
Sla 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLA 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLA 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sla 36
  • 81.54 (n)
  • 86.99 (a)
chicken
(Gallus gallus)
Aves SLA 36
  • 67.27 (n)
  • 68.84 (a)
SLA 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLA 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sla 36
  • 65.87 (n)
  • 65.34 (a)
zebrafish
(Danio rerio)
Actinopterygii sla1 36
  • 57.65 (n)
  • 52.55 (a)
sla1 37
  • 49 (a)
OneToOne
Species with no ortholog for SLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLA Gene

ENSEMBL:
Gene Tree for SLA (if available)
TreeFam:
Gene Tree for SLA (if available)

Paralogs for SLA Gene

Paralogs for SLA Gene

genes like me logo Genes that share paralogs with SLA: view

Variants for SLA Gene

Sequence variations from dbSNP and Humsavar for SLA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
VAR_061706 -

Structural Variations from Database of Genomic Variants (DGV) for SLA Gene

Variant ID Type Subtype PubMed ID
nsv482993 CNV Loss 15286789
nsv6402 CNV Insertion 18451855
nsv525105 CNV Loss 19592680
esv33548 CNV Gain 17666407
nsv465818 CNV Loss 19166990

Relevant External Links for SLA Gene

HapMap Linkage Disequilibrium report
SLA

Disorders for SLA Gene

Relevant External Links for SLA

Genetic Association Database (GAD)
SLA
Human Genome Epidemiology (HuGE) Navigator
SLA
genes like me logo Genes that share disorders with SLA: view

No data available for UniProtKB/Swiss-Prot for SLA Gene

Publications for SLA Gene

  1. Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. (PMID: 8825655) Angrist M. … Pandey A. (Genomics 1995) 2 3 4 23
  2. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. (PMID: 11179692) Kratchmarova I. … Pandey A. (Gene 2001) 2 3 4 23
  3. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PMID: 11696592) Holland S.J. … Wu J. (J. Exp. Med. 2001) 3 4 23
  4. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. (PMID: 9020066) Ohtsuki T. … Miura Y. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  5. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. (PMID: 10662792) Sosinowski T. … Weiss A. (J. Exp. Med. 2000) 3 23

Products for SLA Gene

Sources for SLA Gene

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