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SLA Gene

protein-coding   GIFtS: 57
GCID: GC08M134048

Src-Like-Adaptor

(Previous name: Src-like-adapter)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src-like-adaptor1 2     Src-like-adapter1
Src-Like-Adapter Protein 12 3     SLA12
SLAP2 3     src-like-adapter2
SLAP-12 3     SLAP13
hSLAP2 3     

External Ids:    HGNC: 109021   Entrez Gene: 65032   Ensembl: ENSG000001559267   OMIM: 6010995   UniProtKB: Q132393   

Export aliases for SLA gene to outside databases

Previous GC identifers: GC08M132778 GC08M134136 GC08M133719 GC08M134005 GC08M134118 GC08M129368


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLA Gene:
SLA (Src-like-adaptor) is a protein-coding gene. Diseases associated with SLA include pontocerebellar hypoplasia type 2d, and vitiligo. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SLA2.

UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell
antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation
of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL,
leading to a CBL dependent degradation of signaling proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLA gene promoter:
         USF1   AML1a   POU6F1 (c2)   IRF-1   E47   AREB6   POU2F1   POU2F1a   USF-1   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLA promoter sequence
   Search Chromatin IP Primers for SLA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24.22

SLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M134048:  view genomic region     (about GC identifiers)

Start:
134,048,973 bp from pter      End:
134,115,310 bp from pter
Size:
66,338 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239 (See protein sequence)
Recommended Name: Src-like-adapter  
Size: 276 amino acids; 31156 Da
Subunit: Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction
with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK
and LAT via its SH2 domain
1 PDB 3D structure from and Proteopedia for SLA:
2CUD (3D)    
Secondary accessions: Q9UMQ8

Explore the universe of human proteins at neXtProt for SLA: NX_Q13239

Explore proteomics data for SLA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys60, Lys93, Lys104, Lys117, Lys252, Lys264
  • Modification sites at PhosphoSitePlus

  • See SLA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001039021.1  NP_001039022.2  NP_001269893.1  NP_001269894.1  NP_006739.2  

    ENSEMBL proteins: 
     ENSP00000337548   ENSP00000394049   ENSP00000378759   ENSP00000427928   ENSP00000428559  
     ENSP00000430596   ENSP00000429681   ENSP00000429844   ENSP00000430184   ENSP00000428087  
     ENSP00000428971   ENSP00000429143  

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    Cloud-Clone Corp. Proteins for SLA

    SLA Antibody Products:

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    SLA Assay Products:

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    Cloud-Clone Corp. CLIAs for SLA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q13239

    ProtoNet protein and cluster: Q13239

    1 Blocks protein domain: IPB000980 SH2 domain signature

    UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
    Domain: The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the
    interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region
    is apparently required for the homodimerization
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    SLA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SLAP1_HUMAN, Q13239
    Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell
    antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation
    of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL,
    leading to a CBL dependent degradation of signaling proteins
    Induction: By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins

         Genatlas biochemistry entry for SLA:
    mouse Src-like adaptor protein (Slap) homolog,binding the Eck receptor protein tyrosine kinase,involved in signal
    transduction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS7543898
    GO:0005515protein binding IPI9742401
         
    SLA for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sla):
     cellular  hematopoietic system  immune system 

    SLA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slatm1Weis for SLA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLA
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    Selected qRT-PCR Assays for microRNAs that regulate SLA (see all 20):
    hsa-miR-4254 hsa-miR-181c hsa-miR-1260b hsa-miR-578 hsa-miR-2115 hsa-miR-383 hsa-miR-155 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSLA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLA

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): SLA (NM_001045556)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLA

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SLAP1_HUMAN, Q13239: Cytoplasm (By similarity). Endosome (By similarity). Note=Colocalizes with endosomes (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endosome2
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IEA--

    SLA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLA About    
    See pathways by source

    SuperPathContained pathways About
    1EPHB forward signaling
    Cell adhesion Ephrins signaling0.30
    2PDGFR-beta signaling pathway
    PDGFR-beta signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for SLA
        Cell adhesion Ephrins signaling

    1 BioSystems Pathway for SLA
        PDGFR-beta signaling pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLA
    Interactions:

        GeneGlobe Interaction Network for SLA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SLA (Q132391, 2, 3 ENSP000003940494) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFRBP096191, 2, 3, ENSP000002617994EBI-726214,EBI-641237 MINT-8038085 MINT-8026898 MINT-8026913 MINT-8038100 I2D: score=1 STRING: ENSP00000261799
    ERBB2P046262, 3, ENSP000002695714MINT-74747 I2D: score=1 STRING: ENSP00000269571
    PAFAH1B2P684022, 3MINT-64002 I2D: score=3 
    GSK3BP498412, 3MINT-8257702 I2D: score=2 
    EGFRP005332, 3, ENSP000002754934MINT-74746 I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009967positive regulation of signal transduction TAS7543898

    SLA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLA (SLAP1)

    2 Novoseek inferred chemical compound relationships for SLA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 38.4 6 9020066 (3), 11179692 (1)
    tyrosine 37.2 8 16887961 (2), 8825655 (2), 11179692 (1)



    SLA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLA gene (5 alternative transcripts): 
    NM_001045556.2  NM_001045557.2  NM_001282964.1  NM_001282965.1  NM_006748.3  

    Unigene Cluster for SLA:

    Src-like-adaptor
    Hs.75367  [show with all ESTs]
    Unigene Representative Sequence: BX647569
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000338087(uc011ljd.2 uc003ytz.3 uc011lje.2 uc011ljf.2 uc011ljg.2)
    ENST00000427060 ENST00000395352 ENST00000517549 ENST00000524345 ENST00000517648
    ENST00000522119 ENST00000523224(uc010mdy.1) ENST00000521823 ENST00000519341
    ENST00000522002(uc010mdz.1) ENST00000518565(uc010mea.2) ENST00000520106
    ENST00000522432 ENST00000519504 ENST00000518594 ENST00000521302 ENST00000523610

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLA (see all 20):
    hsa-miR-4254 hsa-miR-181c hsa-miR-1260b hsa-miR-578 hsa-miR-2115 hsa-miR-383 hsa-miR-155 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSLA 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): SLA (NM_001045556)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SLA
      QuantiFast Probe-based Assays in human, mouse, rat SLA

    Additional mRNA sequence: 

    AJ238591.1 AK297423.1 AK297519.1 AK309401.1 AK310092.1 AK310108.1 AK310115.1 AK311010.1 
    AK312584.1 BC007042.1 BT019994.1 BX647569.1 BX648382.1 CR536537.1 D89077.1 U30473.1 
    U44403.1 

    Selected DOTS entries (see all 25):

    DT.75102889  DT.100745672  DT.445563  DT.97816119  DT.92425755  DT.100745673  DT.120642389  DT.120642420 
    DT.120642281  DT.120642349  DT.120642470  DT.120642338  DT.120642459  DT.100000459  DT.100745674  DT.120642180 
    DT.120642235  DT.120642249  DT.120642494  DT.40226559  DT.75151691  DT.95081040  DT.95128762  DT.99965233 

    Selected AceView cDNA sequences (see all 185):

    CB155263 AI696144 AI239511 BQ029750 T33710 BM975355 BQ017607 BE676541 
    CR617946 C01387 BX383094 F05292 CD365707 BQ709240 AI815620 AA813870 
    AW136985 U44403 CR594017 AL597453 BC007042 CR536537 AA651886 Z38323 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLA (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
    SP1:                                                  -           -                       -     -     -                 -                                       
    SP2:              -     -     -     -     -     -     -           -                       -     -     -                 -                                       
    SP3:              -     -     -     -     -     -     -           -                       -                                                                     
    SP4:                                                  -                                                                                                         
    SP5:                                            -     -           -                       -     -     -                                                         


    ECgene alternative splicing isoforms for SLA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLA Expression
    About this image


    SLA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    SLA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75367

    UniProtKB/Swiss-Prot: SLAP1_HUMAN, Q13239
    Tissue specificity: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver,
    skeletal muscle, kidney and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sla1 , 5 src-like adaptor1, 5 80.94(n)1
    86.32(a)1
      15 (29.30 cM)5
    204911  NM_001029841.41  NP_001025012.11 
     667808195 
    chicken
    (Gallus gallus)
    Aves SLA1 Src-like-adaptor 67.27(n)
    68.84(a)
      378908  NM_204391.1  NP_989722.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLA6
    Src-like-adaptor
    61(a)
    1 ↔ 1
    4(746961-775552)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sla1 Src-like-adaptor 65.87(n)
    65.34(a)
      100491564  XM_004915043.1  XP_004915100.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sla11 Src-like-adaptor 1 57.65(n)
    52.55(a)
      571922  NM_001034989.2  NP_001030161.1 


    ENSEMBL Gene Tree for SLA (if available)
    TreeFam Gene Tree for SLA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLA gene
    SLA22  
    11 SIMAP similar genes for SLA using alignment to 11 protein entries:     SLAP1_HUMAN (see all proteins):
    GRAP2    BLK    HCK    FYN    SLA2    GRAPL
    LYN    YES1    LCK    SRC    FGR

    SLA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for SLA    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44861831,2,4
    ----see VAR_0617062 mis40--------

    HapMap Linkage Disequilibrium report for SLA (134048973 - 134115310 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6402CNV Insertion18451855
    nsv465818CNV Loss19166990
    nsv482993CNV Loss15286789
    nsv525105CNV Loss19592680
    esv33548CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601099    OMIM disorders: --

    6 diseases for SLA:    
    About MalaCards
    pontocerebellar hypoplasia type 2d    vitiligo    lymphoblastic leukemia    graves' disease
    leukemia    cerebritis


    SLA for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLA
    Human Genome Epidemiology (HuGE) Navigator: SLA (7 documents)

    Export disorders for SLA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLA gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SLA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. (PubMed id 8825655)1, 2, 3, 9 Angrist M.... Pandey A. (Genomics 1995)
    2. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. (PubMed id 11179692)1, 2, 3, 9 Kratchmarova I....Pandey A. (Gene 2001)
    3. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. (PubMed id 9020066)1, 2, 9 Ohtsuki T....Miura Y. (Biochem. Biophys. Res. Commun. 1997)
    4. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PubMed id 11696592)1, 2, 9 Holland S.J.... Wu J. (J. Exp. Med. 2001)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. (PubMed id 10449770)1, 2 Tang J.... Burakoff S.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    9. The gene for the human Src-like adaptor protein (hSLAP) is located within the 64-kb intron of the thyroglobulin gene. (PubMed id 9660183)1, 2 Meijerink P.H.S.... Baas F. (Eur. J. Biochem. 1998)
    10. Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. (PubMed id 10662792)1, 9 Sosinowski T....Weiss A. (J. Exp. Med. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6503 HGNC: 10902 AceView: SLA Ensembl:ENSG00000155926 euGenes: HUgn6503
    ECgene: SLA H-InvDB: SLA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLA gene:
    Search GeneIP for patents involving SLA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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