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Aliases for SKP2 Gene

Aliases for SKP2 Gene

  • S-Phase Kinase Associated Protein 2 2 3 5
  • S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase 2 3
  • F-Box/LRR-Repeat Protein 1 3 4
  • P45skp2 3 4
  • FBXL1 3 4
  • S-Phase Kinase-Associated Protein 2 (P45) 2
  • CDK2/Cyclin A-Associated Protein P45 3
  • Cyclin-A/CDK2-Associated Protein P45 4
  • S-Phase Kinase-Associated Protein 2 3
  • F-Box Protein Skp2 4
  • FBL1 3
  • FLB1 3
  • P45 3

External Ids for SKP2 Gene

Previous GeneCards Identifiers for SKP2 Gene

  • GC05P036333
  • GC05P037218
  • GC05P036152
  • GC05P036197
  • GC05P036187

Summaries for SKP2 Gene

Entrez Gene Summary for SKP2 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

GeneCards Summary for SKP2 Gene

SKP2 (S-Phase Kinase Associated Protein 2) is a Protein Coding gene. Diseases associated with SKP2 include Lung Cancer and Cervical Squamous Cell Carcinoma. Among its related pathways are Regulation of retinoblastoma protein and Mitotic G1-G1/S phases. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for SKP2 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

Gene Wiki entry for SKP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKP2 Gene

Genomics for SKP2 Gene

Regulatory Elements for SKP2 Gene

Enhancers for SKP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F036150 1.5 FANTOM5 Ensembl ENCODE 7.7 +3.2 3201 9.4 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 NADK2-AS1 UGT3A2 ENSG00000272103 ENSG00000251591 LMBRD2 SKP2 NADK2 RNU6-1305P PIR31598
GH05F036160 0.4 ENCODE 5.1 +9.3 9299 2.2 FOXA3 HNF4G YY1 RANBP3L SKP2 RNU6-1305P PIR31598
GH05F036180 0.6 ENCODE 4.5 +28.6 28625 0.2 ELF3 ATF1 MLX ARID4B DMAP1 RAD21 KAT2B RCOR1 CREM THAP11 RNU6-1305P RANBP3L SKP2 PIR31598 NADK2-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SKP2 on UCSC Golden Path with GeneCards custom track

Promoters for SKP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001278176 -89 3001 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1

Genomic Location for SKP2 Gene

Chromosome:
5
Start:
36,151,989 bp from pter
End:
36,192,788 bp from pter
Size:
40,800 bases
Orientation:
Plus strand

Genomic View for SKP2 Gene

Genes around SKP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKP2 Gene

Proteins for SKP2 Gene

  • Protein details for SKP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13309-SKP2_HUMAN
    Recommended name:
    S-phase kinase-associated protein 2
    Protein Accession:
    Q13309
    Secondary Accessions:
    • A8K5E0
    • B4DJT4
    • Q8TDZ0
    • Q8TDZ1
    • Q9BV69

    Protein attributes for SKP2 Gene

    Size:
    424 amino acids
    Molecular mass:
    47761 Da
    Quaternary structure:
    • Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21.
    SequenceCaution:
    • Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SKP2 Gene

    Alternative splice isoforms for SKP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKP2 Gene

Post-translational modifications for SKP2 Gene

  • Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.
  • Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.
  • Ubiquitination at Lys 145, Lys 228, and Lys 299
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SKP2 (SKP2)

No data available for DME Specific Peptides for SKP2 Gene

Domains & Families for SKP2 Gene

Gene Families for SKP2 Gene

Protein Domains for SKP2 Gene

Suggested Antigen Peptide Sequences for SKP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13309

UniProtKB/Swiss-Prot:

SKP2_HUMAN :
  • Contains 1 F-box domain.
  • Contains 10 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SKP2: view

Function for SKP2 Gene

Molecular function for SKP2 Gene

GENATLAS Biochemistry:
S phase kinase associated protein 2 (p45),involved in regulation of cell cycle
UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

Gene Ontology (GO) - Molecular Function for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 11099048
GO:0016301 kinase activity IEA --
GO:0042802 identical protein binding IPI 22770219
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with SKP2: view
genes like me logo Genes that share phenotypes with SKP2: view

Animal Models for SKP2 Gene

MGI Knock Outs for SKP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKP2 Gene

Localization for SKP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKP2 Gene COMPARTMENTS Subcellular localization image for SKP2 gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SKP2: view

Pathways & Interactions for SKP2 Gene

genes like me logo Genes that share pathways with SKP2: view

UniProtKB/Swiss-Prot Q13309-SKP2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SKP2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000209 protein polyubiquitination TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0008283 cell proliferation TAS 7553852
genes like me logo Genes that share ontologies with SKP2: view

Drugs & Compounds for SKP2 Gene

(9) Drugs for SKP2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Skp2 Inhibitor C1 Pharma 0

(8) Additional Compounds for SKP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SKP2 Gene

Compound Action Cas Number
Skp2 Inhibitor C1 432001-69-9
genes like me logo Genes that share compounds with SKP2: view

Transcripts for SKP2 Gene

Unigene Clusters for SKP2 Gene

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for SKP2 Gene

GeneLoc Exon Structure for
SKP2
ECgene alternative splicing isoforms for
SKP2

Expression for SKP2 Gene

mRNA expression in normal human tissues for SKP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SKP2 Gene

This gene is overexpressed in Platelet (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SKP2 Gene



Protein tissue co-expression partners for SKP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SKP2 Gene:

SKP2

SOURCE GeneReport for Unigene cluster for SKP2 Gene:

Hs.23348
genes like me logo Genes that share expression patterns with SKP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SKP2 Gene

Orthologs for SKP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SKP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKP2 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia SKP2 34 35
  • 90.8 (n)
cow
(Bos Taurus)
Mammalia SKP2 34 35
  • 89.23 (n)
-- 35
  • 87 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Skp2 34
  • 85.15 (n)
mouse
(Mus musculus)
Mammalia Skp2 34 16 35
  • 84.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SKP2 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SKP2 34 35
  • 66.26 (n)
lizard
(Anolis carolinensis)
Reptilia SKP2 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia skp2 34
  • 60.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12754 34
zebrafish
(Danio rerio)
Actinopterygii skp2 34 35
  • 55.29 (n)
wufa10b08 34
fruit fly
(Drosophila melanogaster)
Insecta Skp2 34 35
  • 43.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005297 34
  • 43.66 (n)
worm
(Caenorhabditis elegans)
Secernentea skpt-1 34 35
  • 42.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for SKP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SKP2 Gene

ENSEMBL:
Gene Tree for SKP2 (if available)
TreeFam:
Gene Tree for SKP2 (if available)

Paralogs for SKP2 Gene

Pseudogenes.org Pseudogenes for SKP2 Gene

genes like me logo Genes that share paralogs with SKP2: view

No data available for Paralogs for SKP2 Gene

Variants for SKP2 Gene

Sequence variations from dbSNP and Humsavar for SKP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10045632 -- 36,166,149(+) TAGAG(G/T)ATCCT intron-variant
rs10063940 -- 36,180,011(+) CCCCT(A/T)ATATA intron-variant, utr-variant-3-prime
rs10064044 -- 36,189,341(+) tttcc(C/T)tatct intron-variant
rs10069006 -- 36,186,145(+) aagga(A/G)atttt intron-variant
rs10070454 -- 36,162,063(+) actgc(A/G/T)cttcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKP2 Gene

Variant ID Type Subtype PubMed ID
esv3604707 CNV gain 21293372
nsv524075 CNV loss 19592680
nsv524991 CNV gain 19592680
nsv830262 CNV gain 17160897
nsv968165 CNV duplication 23825009

Variation tolerance for SKP2 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKP2 Gene

Disorders for SKP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SKP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
tongue squamous cell carcinoma
  • squamous-cell carcinoma
breast cancer
  • breast cancer, invasive ductal
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search SKP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SKP2

Genetic Association Database (GAD)
SKP2
Human Genome Epidemiology (HuGE) Navigator
SKP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKP2
genes like me logo Genes that share disorders with SKP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SKP2 Gene

Publications for SKP2 Gene

  1. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. (PMID: 12769844) von der Lehr N. … Larsson L.G. (Mol. Cell 2003) 3 4 22 64
  2. Acetylation-dependent regulation of Skp2 function. (PMID: 22770219) Inuzuka H. … Wei W. (Cell 2012) 3 4 64
  3. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. (PMID: 21571647) Chen M. … Ronai Z.A. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab. (PMID: 19889619) Seki R. … Okamura T. (Ann. Oncol. 2010) 3 22 64

Products for SKP2 Gene

Sources for SKP2 Gene

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