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SKP2 Gene

protein-coding   GIFtS: 67
GCID: GC05P036103

S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein...

(Previous name: S-phase kinase-associated protein 2 (p45))
  Search for SKP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase1 2     FLB12
S-Phase Kinase-Associated Protein 2 (P45)1 2     CDK2/Cyclin A-Associated Protein P452
FBXL12 3     p452
F-Box/LRR-Repeat Protein 12 3     S-Phase Kinase-Associated Protein 22
p45skp22 3     Cyclin-A/CDK2-Associated Protein P453
FBL12     F-Box Protein Skp23

External Ids:    HGNC: 109011   Entrez Gene: 65022   Ensembl: ENSG000001456047   OMIM: 6014365   UniProtKB: Q133093   

Export aliases for SKP2 gene to outside databases

Previous GC identifers: GC05P036333 GC05P037218 GC05P036152 GC05P036197 GC05P036187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SKP2 Gene:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid
motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex
called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins
are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs
containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by
this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich
repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes
phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S
phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established
as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene
generates three transcript variants encoding different isoforms. (provided by RefSeq, Jul 2011)

GeneCards Summary for SKP2 Gene:
SKP2 (S-phase kinase-associated protein 2, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and identical protein binding.

UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309
Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell
cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip
and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes
target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1.
Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes
ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration

Gene Wiki entry for SKP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SKP2 gene promoter:
         AREB6   PPAR-gamma1   STAT3   CUTL1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKP2 promoter sequence
   Search Chromatin IP Primers for SKP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13

SKP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P036103:  view genomic region     (about GC identifiers)

Start:
36,152,091 bp from pter      End:
36,184,421 bp from pter
Size:
32,331 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309 (See protein sequence)
Recommended Name: S-phase kinase-associated protein 2  
Size: 424 amino acids; 47761 Da
Subunit: Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like
complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1.
Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4,
phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21
Sequence caution: Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
6 PDB 3D structures from and Proteopedia for SKP2:
1FQV (3D)        1FS1 (3D)        1FS2 (3D)        1LDK (3D)        2ASS (3D)        2AST (3D)    
Secondary accessions: A8K5E0 B4DJT4 Q8TDZ0 Q8TDZ1 Q9BV69
Alternative splicing: 3 isoforms:  Q13309-1   Q13309-2   Q13309-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKP2: NX_Q13309

Explore proteomics data for SKP2 at MOPED

Post-translational modifications: 

  • Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP131
  • Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes
    cytoplasmic retention. Deacetylated by SIRT31
  • Ubiquitination2 at Lys145, Lys228, Lys299
  • Modification sites at PhosphoSitePlus

  • See SKP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230049.1  NP_005974.2  NP_116026.1  

    ENSEMBL proteins: 
     ENSP00000274254   ENSP00000274255   ENSP00000421941   ENSP00000423188   ENSP00000426004  
     ENSP00000426675   ENSP00000424234   ENSP00000443492  
    Reactome Protein details: Q13309

    SKP2 Human Recombinant Protein Products:

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    Novus Biologicals SKP2 Proteins
    Novus Biologicals SKP2 Lysates
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FBXL: F-boxes / Leucine-rich repeats

    1 InterPro protein domain:
     IPR001810 F-box_dom

    Graphical View of Domain Structure for InterPro Entry Q13309

    ProtoNet protein and cluster: Q13309

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309
    Similarity: Contains 1 F-box domain
    Similarity: Contains 10 LRR (leucine-rich) repeats


    Find genes that share domains with SKP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKP2_HUMAN, Q13309
    Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex
    which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell
    cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip
    and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes
    target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1.
    Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes
    ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration

         Genatlas biochemistry entry for SKP2:
    S phase kinase associated protein 2 (p45),involved in regulation of cell cycle

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI11099048
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with SKP2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SKP2:
     Cell cycle / mitosis defect  Decreased viability  Increased cell death in breast  Increased cell number in G2M,  
     Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Skp2):
     cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  renal/urinary system  reproductive system 

    Find genes that share phenotypes with SKP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Skp2tm1Kin for SKP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SKP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SKP2

    miRNA
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    miRTarBase miRNAs that target SKP2:
    hsa-mir-142-3p (MIRT021626), hsa-mir-21-5p (MIRT030943)

    Block miRNA regulation of human, mouse, rat SKP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SKP2
    SwitchGear 3'UTR luciferase reporter plasmidSKP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SKP2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SKP2 (NM_032637)
    Sino Biological Human cDNA Clone for SKP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKP2
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    Addgene plasmids for SKP2 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SKP2_HUMAN, Q13309: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SKP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKP2 About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Cyclin E associated events during G1/S transition0.86
    Regulation of mitotic cell cycle0.94
    Cyclin A-Cdk2-associated events at S phase entry0.85
    APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G10.93
    S Phase0.78
    SCF(Skp2)-mediated degradation of p27/p210.86
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5E2F mediated regulation of DNA replication
    G1/S Transition0.81
    Mitotic G1-G1/S phases0.81


    Find genes that share SuperPaths with SKP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SKP2
        Estrogen-mediated S-Phase Entry

    2 Cell Signaling Technology (CST) Pathways for SKP2
        Cell Cycle / Checkpoint Control
    Protein Stability

    Selected GeneGo (Thomson Reuters) Pathways for SKP2 (see all 6)
        Cell cycle Role of APC in cell cycle regulation
    Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation

    Selected BioSystems Pathways for SKP2 (see all 9)
        Cell cycle
    Delta-Notch Signaling Pathway
    RB in Cancer
    FOXM1 transcription factor network
    FoxO family signaling


    4 Reactome Pathways for SKP2
        SCF(Skp2)-mediated degradation of p27/p21
    Antigen processing: Ubiquitination & Proteasome degradation
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
    Cyclin D associated events in G1


    Selected Kegg Pathways  (Kegg details for SKP2) (see all 8):
        FoxO signaling pathway
    Cell cycle
    Ubiquitin mediated proteolysis
    Herpes simplex infection
    Epstein-Barr virus infection

    UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SKP2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SKP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SKP2 (Q133091, 2, 3 ENSP000002742554) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBX1P628771, 2, 3, ENSP000002162254EBI-456291,EBI-398523 MINT-6540245 MINT-6540279 MINT-6540206 I2D: score=2 STRING: ENSP00000216225
    CUL1Q136161, 2, 3, ENSP000003268044EBI-456291,EBI-359390 MINT-6540206 I2D: score=6 STRING: ENSP00000326804
    CKS1BP610241, 2, 3, ENSP000003110834EBI-456291,EBI-456371 MINT-6540206 I2D: score=5 STRING: ENSP00000311083
    SPDYAQ5MJ702, 3, ENSP000003356284MINT-7226431 MINT-7226448 I2D: score=1 STRING: ENSP00000335628
    CDKN1BP465271, 3, ENSP000002288724EBI-456291,EBI-519280 I2D: score=5 STRING: ENSP00000228872
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle IEA--
    GO:0000209protein polyubiquitination IEA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process ----

    Find genes that share ontologies with SKP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SKP2

    Selected Novoseek inferred chemical compound relationships for SKP2 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eb 1089 76.1 7 12408227 (3), 11839571 (2), 12586749 (1)
    leptomycin b 55.1 2 15735731 (1)
    ns 398 35.8 4 15645119 (3)
    ly294002 28 5 12242656 (1), 19147533 (1), 17407140 (1)
    paraffin 21.5 3 20426910 (1), 12429803 (1), 11335900 (1)
    rapamycin 20.4 7 16859513 (6)
    troglitazone 13.2 9 12717389 (6), 14618613 (3)
    pioglitazone 10.3 1 12717389 (1)
    estrogen 9.68 6 16024059 (1), 16168119 (1), 18644126 (1), 19168586 (1) (see all 5)
    retinoic acid 8.69 19 18212744 (6), 15735731 (4), 11595732 (4), 12700651 (2) (see all 5)



    Find genes that share compounds with SKP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SKP2 gene (3 alternative transcripts): 
    NM_001243120.1  NM_005983.3  NM_032637.3  

    Unigene Cluster for SKP2:

    S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
    Hs.23348  [show with all ESTs]
    Unigene Representative Sequence: NM_005983
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274254(uc003jkd.3) ENST00000274255(uc003jkc.2 uc011cou.2)
    ENST00000508514 ENST00000513151 ENST00000509692 ENST00000513263 ENST00000504386
    ENST00000546211
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKP2
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    Additional mRNA sequence: 

    AB050979.1 AB050980.1 AB050981.1 AK026224.1 AK291255.1 AK295152.1 AK296223.1 AY029177.1 
    BC001441.2 BC007441.2 U33761.1 

    10 DOTS entries:

    DT.105392  DT.75159204  DT.312862  DT.120824110  DT.100653377  DT.97864569  DT.100653376  DT.97794969 
    DT.100720748  DT.95374574 

    Selected AceView cDNA sequences (see all 174):

    BM925946 BM541586 CA390802 BM846064 BM798641 AA988508 AB050980 BU193122 
    AU136769 NM_032637 BU540915 BE207770 BE271494 AA036678 AK026224 BE645777 
    AI801919 AI620019 AI559886 C02356 CR616738 AI867147 BU622724 AA232795 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SKP2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:                                                                                            -     -     -               
    SP2:                                                                                            -                           
    SP3:                                                                                                  -     -               
    SP4:                                      -                                                                                 
    SP5:                                -     -     -     -     -     -     -     -                 -                           


    ECgene alternative splicing isoforms for SKP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SKP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGAGTAAT
    SKP2 Expression
    About this image


    SKP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Hippocampus
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    SKP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23348
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SKP2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Cell Cycle in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SKP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skp21 , 5 S-phase kinase-associated protein 2 (p45)1, 5 84.83(n)1
    86.32(a)1
      15 (3.84 cM)5
    274011  NM_013787.31  NP_038815.11 
     91119855 
    chicken
    (Gallus gallus)
    Aves SKP21 S-phase kinase-associated protein 2, E3 ubiquitin protein more 66.26(n)
    68.45(a)
      427437  NM_001007982.1  NP_001007983.1 
    lizard
    (Anolis carolinensis)
    Reptilia SKP26
    S-phase kinase-associated protein 2, E3 ubiquitin ...
    62(a)
    1 ↔ 1
    GL343241.1(1551654-1563808)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.127542 Xenopus laevis transcribed sequence with weak similarity more 69.99(n)    BJ068744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa10b082 wufa10b08 72.27(n)   334937  57042926 
    fruit fly
    (Drosophila melanogaster)
    Insecta Skp21 Skp2 43.94(n)
    33.52(a)
      40548  NM_164341.3  NP_730816.2 
    worm
    (Caenorhabditis elegans)
    Secernentea skpt-11 skpt-1 42.18(n)
    30.74(a)
      175749  NM_171121.3  NP_741136.1 


    ENSEMBL Gene Tree for SKP2 (if available)
    TreeFam Gene Tree for SKP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SKP2 gene

    Find genes that share paralogs with SKP2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SKP2
    PGOHUM00000238257 PGOHUM00000241900


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SKP2 (see all 720)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44525791,2
    C,H--36094149(+) GGGGCA/CAACTA 3 -- us2k13Minor allele frequency- C:0.00EA NS 288
    rs1821473021,2
    --36094248(+) TTCCCA/GGGTAA 3 -- us2k10--------
    rs1464645071,2
    --36094331(+) TTCCTA/GTCTAT 3 -- us2k10--------
    rs1857901851,2
    --36094339(+) TATGAA/GATCTA 3 -- us2k10--------
    rs1901660131,2
    --36094448(+) CTTACA/GGGCTC 3 -- us2k10--------
    rs789367281,2
    C,F--36094506(+) AAAAAT/CATTTT 3 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1157552781,2
    F--36094579(+) CTTAGC/GCAAAG 3 -- us2k11Minor allele frequency- G:0.02NA 120
    rs756036091,2
    --36094711(+) GTTGTG/TAACAG 3 -- us2k10--------
    rs1831611181,2
    --36094727(+) TTCTTG/TACACC 3 -- us2k10--------
    rs1883504931,2
    --36094733(+) ACACCA/CATCTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SKP2 (36152091 - 36184421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SKP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524075CNV Loss19592680
    nsv830262CNV Gain17160897
    nsv524991CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing SKP2:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing SKP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SKP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601436    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SKP2:
    Cancer

    Find genes that share disorders with SKP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SKP2 gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aggressiveness 59 13 12796697 (2), 16428491 (2), 15483027 (2), 16168119 (1) (see all 8)
    tumors 54.2 181 15642212 (5), 16525656 (5), 19094580 (4), 11309491 (4) (see all 82)
    cancer 53.5 129 17308064 (4), 18260093 (4), 18922157 (3), 20526532 (3) (see all 65)
    laryngeal squamous cell carcinoma 50.2 10 12579266 (2), 16075976 (2), 19961778 (1), 18800682 (1)
    retinoblastoma 46.8 7 19966802 (1), 12783864 (1), 18074352 (1), 19168586 (1) (see all 6)
    neoplasms cervical 46.4 3 17581405 (2), 17079005 (1)
    carcinoma squamous cell 41.1 18 15767556 (4), 14707456 (2), 15215173 (1), 19094580 (1) (see all 13)
    cervical squamous cell carcinoma 41.1 2 19094580 (2)
    superficial gastritis 39.7 5 16405750 (2), 16425372 (2)
    precancerous lesions 38.3 5 19094580 (2), 16075976 (1), 17345711 (1)

    Genetic Association Database (GAD): SKP2
    Human Genome Epidemiology (HuGE) Navigator: SKP2 (7 documents)

    Export disorders for SKP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SKP2 gene, integrated from 10 sources (see all 512):
    (articles sorted by number of sources associating them with SKP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. (PubMed id 12769844)1, 2, 9 von der Lehr N.... Larsson L.G. (Mol. Cell 2003)
    2. Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation. (PubMed id 16103164)1, 2, 9 Barboric M.... Peterlin B.M. (J. Virol. 2005)
    3. The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. (PubMed id 12840033)1, 2, 9 Li X.... Wu X. (J. Biol. Chem. 2003)
    4. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PubMed id 8646875)1, 3, 9 Demetrick D.J....Beach D.H. (Cytogenet. Cell Genet. 1996)
    5. Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes. (PubMed id 19587092)1, 4, 9 Yu J.C....Shen C.Y. (Carcinogenesis 2009)
    6. Acetylation-dependent regulation of Skp2 function. (PubMed id 22770219)1, 2 Inuzuka H.... Wei W. (Cell 2012)
    7. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. (PubMed id 21571647)1, 2 Chen M.... Ronai Z.A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    8. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. (PubMed id 19738611)1, 4 Cunningham J.M....Goode E.L. (Br. J. Cancer 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6502 HGNC: 10901 AceView: SKP2 Ensembl:ENSG00000145604 euGenes: HUgn6502
    ECgene: SKP2 Kegg: 6502 H-InvDB: SKP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SKP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SKP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SKP2 gene:
    Search GeneIP for patents involving SKP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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