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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SKP2 Gene

protein-coding GIFtS: 63
GCID: GC05P036103

S-phase kinase-associated protein 2, E3 ubiquitin protein...

(Previous name: S-phase kinase-associated protein 2 (p45) )

Explore 70 diseases affiliated with
SKP2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase¹ ²		P45skp2¹
FBXL1¹ ² ³		FLB1²
FBL1¹ ²		CDK2/Cyclin A-Associated Protein P45²
P45¹		S-Phase Kinase-Associated Protein 2²
S-Phase Kinase-Associated Protein 2 (P45)¹ ²		Cyclin-A/CDK2-Associated Protein P45³
F-Box/LRR-Repeat Protein 1² ³		F-Box Protein Skp2³

External Ids:	HGNC: 10901¹	Entrez Gene: 6502²	Ensembl: ENSG00000145604⁷	OMIM: 601436⁵	UniProtKB: Q13309³

Export aliases for SKP2 gene to outside databases

Previous GC identifers: GC05P036333 GC05P037218 GC05P036152 GC05P036197 GC05P036187

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SKP2:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif,

the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs

(SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3

classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different

protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls

class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential

element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase

inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase

kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved

in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding

different isoforms. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309

Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which

mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle

progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is

involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins

ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires

STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1

in a CK1-Dependent Manner, thereby regulating cell migration

Gene Wiki entry for SKP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SKP2 gene promoter:
AREB6 PPAR-gamma1 STAT3 CUTL1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SKP2 promoter sequence

Search SABiosciences Chromatin IP Primers for SKP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13 Ensembl cytogenetic band: 5p13.2 HGNC cytogenetic band: 5p13

SKP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKP2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P036103: view genomic region (about GC identifiers)

Start:	36,152,091 bp from pter	End:	36,184,421 bp from pter
Size:	32,331 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309 (See protein sequence)

Recommended Name: S-phase kinase-associated protein 2

Size: 424 amino acids; 47761 Da

Subunit: Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex

containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the

cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2,

FOXO1, UBP43, MYC, TOB1, TAL1 and MLL. Interacts with TRIM21

Subcellular location: Cytoplasm. Nucleus

Sequence caution: Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

6 PDB 3D structures from and Proteopedia for SKP2:

1FQV (3D)

1FS1 (3D)

1FS2 (3D)

1LDK (3D)

2ASS (3D)

2AST (3D)

Secondary accessions: A8K5E0 B4DJT4 Q8TDZ0 Q8TDZ1 Q9BV69

Alternative splicing: 3 isoforms: Q13309-1 Q13309-2 Q13309-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKP2: NX_Q13309

Post-translational modifications:

Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13¹

Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes

cytoplasmic retention. Deacetylated by SIRT3¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13309

SKP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001230049.1 NP_005974.2 NP_116026.1

ENSEMBL proteins:

ENSP00000274254 ENSP00000274255 ENSP00000421941 ENSP00000423188 ENSP00000426004

ENSP00000426675 ENSP00000424234 ENSP00000443492

Reactome Protein details: Q13309
Human Recombinant Protein Products:

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	Novus Biologicals SKP2 Proteins Novus Biologicals SKP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SKP2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0019005	SCF ubiquitin ligase complex	IDA	16880511

SKP2 for ontologies About GeneDecksing

SKP2 Antibody Products:

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	Uscn ELISAs and CLIAs for SKP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SKP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR001810 F-box_dom_cyclin-like

Graphical View of Domain Structure for InterPro Entry Q13309

ProtoNet protein and cluster: Q13309

1 Blocks protein family: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309

Similarity: Contains 1 F-box domain

Similarity: Contains 10 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309

Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which

mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle

progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is

involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins

ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires

STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1

in a CK1-Dependent Manner, thereby regulating cell migration

Genatlas biochemistry entry for SKP2:

S phase kinase associated protein 2 (p45),involved in regulation of cell cycle

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SKP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SKP2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SKP2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKP2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0016301	kinase activity	--	--
GO:0042802	identical protein binding	IPI	--

SKP2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for SKP2:

Cell cycle / mitosis defect	Decreased viability	Increased cell death in breast	Increased cell number in G2M,
Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Skp2^tm1Kin for SKP2
9 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Skp2):

cellular	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	liver/biliary system	renal/urinary system	reproductive system

SKP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/25 super-pathways (see all 25) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/9 pathways (see all 9)
Degradation of ubiquitinated p27/p21 by the 26S proteasome	0.75	Cyclin A:Cdk2-associated events at S phase entry	0.66
SCF(Skp2)-mediated degradation of p27/p21	0.75	Regulation of mitotic cell cycle	0.58
APC/C:Cdh1-mediated degradation of Skp2	0.74	APC/C-mediated degradation of cell cycle proteins	0.58
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.69	S Phase	0.40

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Role of SCF complex in cell cycle regulation

Cell cycle_Role of SCF complex in cell cycle regulation

1.00

Cell cycle Role of SCF complex in cell cycle regulation

0.98

Immune response_MIF-JAB1 signaling

Immune response_MIF-JAB1 signaling

1.00

Immune response MIF-JAB1 signaling

0.97

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for SKP2 (see all 6)

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle ESR1 regulation of G1/S transition
	Proteolysis Putative ubiquitin pathway
	Immune response MIF-JAB1 signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SKP2

Estrogen-mediated S-Phase Entry

2 Cell Signaling Technology (CST) Pathways for SKP2

	Cell Cycle / Checkpoint Control
	Protein Stability

5/6 GeneGo (Thomson Reuters) Pathways for SKP2 (see all 6)

	Cell cycle Role of APC in cell cycle regulation
	Cell cycle ESR1 regulation of G1/S transition
	Cell cycle Regulation of G1/S transition (part 1)
	Proteolysis Putative ubiquitin pathway
	Cell cycle Role of SCF complex in cell cycle regulation

5/8 BioSystems Pathways for SKP2 (see all 8)

	Cell cycle
	Delta-Notch Signaling Pathway
	FOXM1 transcription factor network
	Regulation of retinoblastoma protein
	C-MYC pathway

5/20 Reactome Pathways for SKP2 (see all 20)

	SCF(Skp2)-mediated degradation of p27/p21
	Mitotic G1-G1/S phases
	Cell Cycle
	Degradation of ubiquitinated p27/p21 by the 26S proteasome
	S Phase

4 Kegg Pathways (Kegg details for SKP2):

	Cell cycle
	Ubiquitin mediated proteolysis
	Pathways in cancer
	Small cell lung cancer

UniProtKB/Swiss-Prot: SKP2_HUMAN, Q13309

Pathway: Protein modification; protein ubiquitination

SKP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SKP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/192 Interacting proteins for SKP2 (Q13309^{1, 2, 3} ENSP00000274255⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 192)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUL1	Q13616¹^,²^,³, ENSP00000326804⁴	EBI-456291,EBI-359390 MINT-6540206 I2D: score=6 STRING: ENSP00000326804
CKS1B	P61024¹^,²^,³, ENSP00000311083⁴	EBI-456291,EBI-456371 MINT-6540206 I2D: score=5 STRING: ENSP00000311083
RBX1	P62877²^,³, ENSP00000216225⁴	MINT-6540245 MINT-6540279 MINT-6540206 I2D: score=2 STRING: ENSP00000216225
SPDYA	Q5MJ70²^,³, ENSP00000335628⁴	MINT-7226431 MINT-7226448 I2D: score=1 STRING: ENSP00000335628
CDKN1B	P46527¹^,³, ENSP00000228872⁴	EBI-456291,EBI-519280 I2D: score=5 STRING: ENSP00000228872

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	IEA	--
GO:0000209	protein polyubiquitination	IEA	--

SKP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SKP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SKP2
10/16 Novoseek chemical compound relationships for SKP2 gene (see all 16) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
eb 1089	76.1	7	12408227 (3), 11839571 (2), 12586749 (1)
leptomycin b	55.1	2	15735731 (1)
ns 398	35.8	4	15645119 (3)
ly294002	28	5	12242656 (1), 19147533 (1), 17407140 (1)
paraffin	21.5	3	20426910 (1), 12429803 (1), 11335900 (1)
rapamycin	20.4	7	16859513 (6)
troglitazone	13.2	9	12717389 (6), 14618613 (3)
pioglitazone	10.3	1	12717389 (1)
estrogen	9.68	6	16024059 (1), 16168119 (1), 18644126 (1), 19168586 (1) (see all 5)
retinoic acid	8.69	19	18212744 (6), 15735731 (4), 11595732 (4), 12700651 (2) (see all 5)

Search CenterWatch for drugs/clinical trials and news about SKP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SKP2 gene (3 alternative transcripts):

NM_001243120.1 NM_005983.3 NM_032637.3

Unigene Cluster for SKP2:

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Hs.23348 [show with all ESTs]

Unigene Representative Sequence: NM_005983

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000274254(uc003jkd.3) ENST00000274255(uc003jkc.2 uc011cou.2)

ENST00000508514 ENST00000513151 ENST00000509692 ENST00000513263 ENST00000504386

ENST00000546211

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKP2

Additional cDNA sequence:

AB050979.1 AB050980.1 AB050981.1 AK026224.1 AK291255.1 AK295152.1 AK296223.1 AY029177.1

BC001441.2 BC007441.2 U33761.1

10 DOTS entries:

DT.105392 DT.75159204 DT.312862 DT.120824110 DT.100653377 DT.97864569 DT.100653376 DT.97794969

DT.100720748 DT.95374574

24/174 AceView cDNA sequences (see all 174):

BE271494 BE207770 BM541586 AI801919 AW074277 BI850432 BU540915 BU193122

CR616738 AA988508 AI559886 BM458886 BX952434 BI759081 AW518513 AI867147

AB050979 BM846064 AK026224 CA390802 AU136769 AA036678 BU622724 BE253981

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SKP2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b
SP1:																															-		-		-
SP2:																															-
SP3:																																	-		-
SP4:													-
SP5:											-		-		-		-		-		-		-		-						-

ECgene alternative splicing isoforms for SKP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SKP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGAGTAAT

About this image
See SKP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SKP2

SOURCE GeneReport for Unigene cluster: Hs.23348

SABiosciences Expression via Pathway-Focused PCR Arrays including SKP2:

Ubiquitination (Ubiquitylation) Pathway in human mouse rat

Cell Cycle in human mouse rat

Cancer PathwayFinder in human mouse rat

Ubiquitin Ligases in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SKP2 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Skp2^{1 , 5}	S-phase kinase-associated protein 2 (p45)^{1, 5}	84.83(n)¹ 86.32(a)¹		15 (3.84 cM)⁵ 27401¹ NM_013787.2¹ NP_038815.1¹ 9111985⁵
chicken (Gallus gallus)	Aves	SKP2¹	S-phase kinase-associated protein 2 (p45)	66.1(n) 68.19(a)		427437 NM_001007982.1 NP_001007983.1
lizard (Anolis carolinensis)	Reptilia	SKP2⁶	--	63(a)	1 ↔ 1	GL343241.1(1551654-1563808)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12754²	Xenopus laevis transcribed sequence with weak similarity more	69.99(n)		BJ068744.1
zebrafish (Danio rerio)	Actinopterygii	wufa10b08²	wufa10b08	72.27(n)		334937 57042926
fruit fly (Drosophila melanogaster)	Insecta	CG9772¹	CG9772	44.38(n) 34.94(a)		40548 NM_164341.3 NP_730816.2
worm (Caenorhabditis elegans)	Secernentea	skpt-1¹	Protein SKPT-1	42.18(n) 30.74(a)		175749 NM_171121.2 NP_741136.1

ENSEMBL Gene Tree for SKP2 (if available)
TreeFam Gene Tree for SKP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SKP2 gene

SKP2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SKP2
PGOHUM00000238257 PGOHUM00000241900

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4452579^1,2	C,H	--	36150267(+)	`GGGGCA/CAACTA`	4	--	us2k¹ int¹		3		EA NS	288
rs182147302^1,2		--	36150366(+)	`TTCCCA/GGGTAA`	4	--	us2k¹ int¹		0	--	--	--	--
rs146464507^1,2		--	36150449(+)	`TTCCTA/GTCTAT`	4	--	us2k¹ int¹		0	--	--	--	--
rs185790185^1,2		--	36150457(+)	`TATGAA/GATCTA`	4	--	us2k¹ int¹		0	--	--	--	--
rs190166013^1,2		--	36150566(+)	`CTTACA/GGGCTC`	4	--	us2k¹ int¹		0	--	--	--	--
rs78936728^1,2	F,	--	36150624(+)	`AAAAAT/CATTTT`	4	--	us2k¹ int¹		1		WA	118
rs115755278^1,2	F,	--	36150697(+)	`CTTAGC/GCAAAG`	4	--	int¹ us2k¹		1		NA	120
rs75603609^1,2		--	36150829(+)	`GTTGTG/TAACAG`	4	--	int¹ us2k¹		0	--	--	--	--
rs183161118^1,2		--	36150845(+)	`TTCTTG/TACACC`	4	--	int¹ us2k¹		0	--	--	--	--
rs188350493^1,2		--	36150851(+)	`ACACCA/CATCTC`	4	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SKP2 (36152091 - 36184421 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SKP2: --

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing SKP2:

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SKP2 for disorders           About GeneDecksing

OMIM gene information: 601436    OMIM disorders: --

20/70 diseases for SKP2 (see all 70):    About MalaCards

diffuse large b-cell lymphoma squamous cell carcinoma non-small cell lung carcinoma b-cell lymphomas

laryngeal squamous cell carcinoma cervical squamous cell carcinoma non-hodgkin lymphoma soft tissue sarcoma

primary effusion lymphoma carcinoma urinary bladder cancer adenoid cystic carcinoma

oral squamous cell carcinoma merkel cell carcinoma esophageal squamous cell carcinoma benign tumors

hodgkin's lymphoma pancreatic ductal adenocarcinoma pituitary tumor laryngitis

1 disease from the University of Copenhagen DISEASES database for SKP2:

Cancer

10/55 Novoseek disease relationships for SKP2 gene (see all 55) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
aggressiveness	59	13	12796697 (2), 16428491 (2), 15483027 (2), 16168119 (1) (see all 8)
tumors	54.2	181	15642212 (5), 16525656 (5), 19094580 (4), 11309491 (4) (see all 82)
cancer	53.5	129	17308064 (4), 18260093 (4), 18922157 (3), 20526532 (3) (see all 65)
laryngeal squamous cell carcinoma	50.2	10	12579266 (2), 16075976 (2), 19961778 (1), 18800682 (1)
retinoblastoma	46.8	7	19966802 (1), 12783864 (1), 18074352 (1), 19168586 (1) (see all 6)
neoplasms cervical	46.4	3	17581405 (2), 17079005 (1)
carcinoma squamous cell	41.1	18	15767556 (4), 14707456 (2), 15215173 (1), 19094580 (1) (see all 13)
cervical squamous cell carcinoma	41.1	2	19094580 (2)
superficial gastritis	39.7	5	16405750 (2), 16425372 (2)
precancerous lesions	38.3	5	19094580 (2), 16075976 (1), 17345711 (1)

Human Genome Epidemiology (HuGE) Navigator: SKP2 (7 documents)

Export disorders for SKP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SKP2 gene, integrated from 9 sources (see all 477):
(articles sorted by number of sources associating them with SKP2)

Utopia: connect your pdf to the dynamic
world of online information

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. (PubMed id 12769844)^{1, 2, 9} von der Lehr N....Larsson L.G. (2003)
Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation. (PubMed id 16103164)^{1, 2, 9} Barboric M.... Peterlin B.M. (2005)
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. (PubMed id 12840033)^{1, 2, 9} Li X.... Wu X. (2003)
Chromosomal mapping of the genes for the human CDK2/c yclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PubMed id 8646875)^{1, 3, 9} Demetrick D.J....Beach D.H. (1996)
Acetylation-dependent regulation of Skp2 function. (PubMed id 22770219)^{1, 2} Inuzuka H.... Wei W. (2012)
Ubiquitin-recognition protein Ufd1 couples the endopl asmic reticulum (ER) stress response to cell cycle control. (PubMed id 21571647)^{1, 2} Chen M....Ronai Z.A. (2011)
Ubiquitination and degradation of Tal1/SCL are induced by Notch signaling and depend on Skp2 and CHIP. (PubMed id 17962192)^{1, 2} Nie L.... Sun X.H. (2008)
Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions. (PubMed id 17908926)^{1, 2} Liu H.... Hsieh J.J. (2007)
Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination. (PubMed id 16951159)^{1, 2} Hiramatsu Y....Kitagawa M. (2006)
The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. (PubMed id 16581786)^{1, 2} Liu Y....Nimer S.D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6502	HGNC: 10901	AceView: SKP2	Ensembl:ENSG00000145604	euGenes: HUgn6502
ECgene: SKP2	Kegg: 6502	H-InvDB: SKP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SKP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SKP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SKP2 gene
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Patent Information for SKP2 gene:
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