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Aliases for SKP2 Gene

Aliases for SKP2 Gene

  • S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase 2 3
  • S-Phase Kinase-Associated Protein 2 (P45) 2 3
  • F-Box/LRR-Repeat Protein 1 3 4
  • P45skp2 3 4
  • FBXL1 3 4
  • CDK2/Cyclin A-Associated Protein P45 3
  • Cyclin-A/CDK2-Associated Protein P45 4
  • S-Phase Kinase-Associated Protein 2 3
  • F-Box Protein Skp2 4
  • FBL1 3
  • FLB1 3
  • P45 3

External Ids for SKP2 Gene

Previous GeneCards Identifiers for SKP2 Gene

  • GC05P036333
  • GC05P037218
  • GC05P036152
  • GC05P036197
  • GC05P036187

Summaries for SKP2 Gene

Entrez Gene Summary for SKP2 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

GeneCards Summary for SKP2 Gene

SKP2 (S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with SKP2 include hepatocellular carcinoma and prostate cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Pathways in cancer. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for SKP2 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

Gene Wiki entry for SKP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKP2 Gene

Genomics for SKP2 Gene

Regulatory Elements for SKP2 Gene

Genomic Location for SKP2 Gene

Start:
36,151,989 bp from pter
End:
36,184,319 bp from pter
Size:
32,331 bases
Orientation:
Plus strand

Genomic View for SKP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKP2 Gene

Proteins for SKP2 Gene

  • Protein details for SKP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13309-SKP2_HUMAN
    Recommended name:
    S-phase kinase-associated protein 2
    Protein Accession:
    Q13309
    Secondary Accessions:
    • A8K5E0
    • B4DJT4
    • Q8TDZ0
    • Q8TDZ1
    • Q9BV69

    Protein attributes for SKP2 Gene

    Size:
    424 amino acids
    Molecular mass:
    47761 Da
    Quaternary structure:
    • Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21.
    SequenceCaution:
    • Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SKP2 Gene

    Alternative splice isoforms for SKP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKP2 Gene

Proteomics data for SKP2 Gene at MOPED

Post-translational modifications for SKP2 Gene

  • Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.
  • Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.
  • Ubiquitination at Lys145, Lys228, and Lys299
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SKP2 Gene

Domains for SKP2 Gene

Gene Families for SKP2 Gene

HGNC:
  • FBXL :F-boxes / Leucine-rich repeats

Protein Domains for SKP2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SKP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q13309

UniProtKB/Swiss-Prot:

SKP2_HUMAN :
  • Q13309
Domain:
  • Contains 1 F-box domain.
Similarity:
  • Contains 10 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with SKP2: view

Function for SKP2 Gene

Molecular function for SKP2 Gene

GENATLAS Biochemistry: S phase kinase associated protein 2 (p45),involved in regulation of cell cycle
UniProtKB/Swiss-Prot Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.

Gene Ontology (GO) - Molecular Function for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 11099048
GO:0042802 identical protein binding IPI 22770219
genes like me logo Genes that share ontologies with SKP2: view
genes like me logo Genes that share phenotypes with SKP2: view

Animal Models for SKP2 Gene

MGI Knock Outs for SKP2:

miRNA for SKP2 Gene

miRTarBase miRNAs that target SKP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SKP2 Gene

Localization for SKP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKP2 Gene COMPARTMENTS Subcellular localization image for SKP2 gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SKP2: view

Pathways for SKP2 Gene

genes like me logo Genes that share pathways with SKP2: view

UniProtKB/Swiss-Prot Q13309-SKP2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0000209 protein polyubiquitination IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0006511 ubiquitin-dependent protein catabolic process --
genes like me logo Genes that share ontologies with SKP2: view

Compounds for SKP2 Gene

(16) Novoseek inferred chemical compound relationships for SKP2 Gene

Compound -log(P) Hits PubMed IDs
eb 1089 76.1 6
leptomycin b 55.1 1
ns 398 35.8 3
ly294002 28 3
paraffin 21.5 3
genes like me logo Genes that share compounds with SKP2: view

Transcripts for SKP2 Gene

Unigene Clusters for SKP2 Gene

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for SKP2 Gene

GeneLoc Exon Structure for
SKP2
ECgene alternative splicing isoforms for
SKP2

Expression for SKP2 Gene

mRNA expression in normal human tissues for SKP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKP2 Gene

SOURCE GeneReport for Unigene cluster for SKP2 Gene Hs.23348

genes like me logo Genes that share expressions with SKP2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SKP2 Gene

Orthologs for SKP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SKP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKP2 35
  • 99.84 (n)
  • 100 (a)
SKP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
SKP2 35
  • 89.23 (n)
  • 90.57 (a)
SKP2 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SKP2 35
  • 90.8 (n)
  • 92.69 (a)
SKP2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skp2 35
  • 84.83 (n)
  • 86.32 (a)
Skp2 16
Skp2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKP2 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Skp2 35
  • 85.15 (n)
  • 88.15 (a)
chicken
(Gallus gallus)
Aves SKP2 35
  • 66.26 (n)
  • 68.45 (a)
SKP2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKP2 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12754 35
tropical clawed frog
(Silurana tropicalis)
Amphibia skp2 35
  • 60.52 (n)
  • 58.01 (a)
zebrafish
(Danio rerio)
Actinopterygii skp2 35
  • 55.29 (n)
  • 47.85 (a)
skp2 36
  • 45 (a)
OneToOne
wufa10b08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005297 35
  • 43.66 (n)
  • 34.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Skp2 35
  • 43.94 (n)
  • 33.52 (a)
Skp2 36
  • 22 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea skpt-1 35
  • 42.18 (n)
  • 30.74 (a)
skpt-1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for SKP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SKP2 Gene

ENSEMBL:
Gene Tree for SKP2 (if available)
TreeFam:
Gene Tree for SKP2 (if available)

Paralogs for SKP2 Gene

Pseudogenes.org Pseudogenes for SKP2 Gene

genes like me logo Genes that share paralogs with SKP2: view

No data available for Paralogs for SKP2 Gene

Variants for SKP2 Gene

Sequence variations from dbSNP and Humsavar for SKP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27127 -- 36,175,914(+) ACTGG(A/G)CCAAA intron-variant
rs27128 -- 36,175,972(+) GTTCA(C/G)TATCC intron-variant
rs27129 -- 36,163,309(+) CCACA(C/G)CCTCC intron-variant
rs27130 -- 36,180,685(-) TAGTC(A/G)TTCAT intron-variant
rs27505 -- 36,165,705(+) TGGTC(C/G)ACTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKP2 Gene

Variant ID Type Subtype PubMed ID
nsv830262 CNV Gain 17160897
nsv524991 CNV Gain 19592680
nsv524075 CNV Loss 19592680

Relevant External Links for SKP2 Gene

HapMap Linkage Disequilibrium report
SKP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKP2 Gene

Disorders for SKP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SKP2 Gene including...

Search for SKP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SKP2 Gene

(55) Novoseek inferred disease relationships for SKP2 Gene

Disease -log(P) Hits PubMed IDs
aggressiveness 59 11
tumors 54.2 128
cancer 53.5 88
laryngeal squamous cell carcinoma 50.2 6
retinoblastoma 46.8 6

Relevant External Links for SKP2

Genetic Association Database (GAD)
SKP2
Human Genome Epidemiology (HuGE) Navigator
SKP2
genes like me logo Genes that share disorders with SKP2: view

No data available for UniProtKB/Swiss-Prot for SKP2 Gene

Publications for SKP2 Gene

  1. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. (PMID: 12769844) von der Lehr N. … Larsson L.G. (Mol. Cell 2003) 3 4 23
  2. Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes. (PMID: 19587092) Yu J.C. … Shen C.Y. (Carcinogenesis 2009) 3 23 48
  3. Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. (PMID: 19615363) Park T.J. … Lim I.K. (Exp. Cell Res. 2009) 3 23
  4. Transcriptional repression of SKP2 is impaired in MYCN-amplified neuroblastoma. (PMID: 20424123) Muth D. … Westermann F. (Cancer Res. 2010) 3 23
  5. The role of Skp2 in extranodal NK/T-cell lymphoma. (PMID: 20426910) Guo H.Q. … Lin T.Y. (Chin J Cancer 2010) 3 23

Products for SKP2 Gene

  • Addgene plasmids for SKP2

Sources for SKP2 Gene

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