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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SKP1 Gene

protein-coding GIFtS: 62
GCID: GC05M133521

S-phase kinase-associated protein 1

(Previous name: S-phase kinase-associated protein 1A (p19A) )
(Previous symbol: SKP1A)

Explore 18 diseases affiliated with
SKP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
S-Phase Kinase-Associated Protein 1¹ ²		Transcription Elongation Factor B² ³
OCP2¹ ² ³ ⁵		OCP-2² ³
SKP1A¹ ² ³ ⁵		SIII² ³
TCEB1L¹ ² ³ ⁵		P19skp1¹
EMC19¹ ² ³		MGC34403¹
OCP-II¹ ² ³		S-Phase Kinase-Associated Protein 1A (P19A)¹
P19A¹		Cyclin A/CDK2-Associated P19²
Cyclin-A/CDK2-Associated Protein P19² ³		Cyclin A/CDK2-Associated Protein P19²
Organ Of Corti Protein 2² ³		RNA Polymerase II Elongation Factor-Like Protein OCP2²
Organ Of Corti Protein II² ³		RNA Polymerase II Elongation Factor-Like Protein³

External Ids:	HGNC: 10899¹	Entrez Gene: 6500²	Ensembl: ENSG00000113558⁷	OMIM: 601434⁵	UniProtKB: P63208³

Export aliases for SKP1 gene to outside databases

Previous GC identifer: GC05M128677

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SKP1:

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and

one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins.

SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for

degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF

substrates have been identified including regulators of cell cycle progression and development. Studies have also

characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two

transcript variants. A related pseudogene has been identified on chromosome 7. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208

Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the

ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF

complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at

'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to

activate transcription. SCF(Cyclin F) directs ubiquitination of CP110

Gene Wiki entry for SKP1 (SKP1A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SKP1 gene promoter:
Nkx3-1 S8 POU2F1 POU2F1a Nkx3-1 v1 Pax-4a Ik-1 GATA-2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SKP1 promoter sequence

Search SABiosciences Chromatin IP Primers for SKP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31

SKP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKP1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M133521: view genomic region (about GC identifiers)

Start:	133,492,082 bp from pter	End:	133,561,762 bp from pter
Size:	69,681 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208 (See protein sequence)

Recommended Name: S-phase kinase-associated protein 1

Size: 163 amino acids; 18658 Da

Subunit: Component of an E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.

Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. Part of a SCF(BTRC)-like complex lacking CUL1,

which is associated with phosphorylated NFKBIA and RELA; RELA interacts directly with NFKBIA. Component of the

SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Identified in a complex with SKP2, CKS1B and CDKN1B. Interacts

with the cyclin A/CDK2 complex. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of several

SCF complexes containing SKP1 and one of the F-box proteins. Component of a SCF(SKP2)-like complex containing CUL1,

SKP1, TRIM21 and SKP2. Interacts with FBXO2, FBXO4, FBXW7 and TRIM21. Interacts with FBXO45 (By similarity). Component

of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1,

CUL1 and FBXO27. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF

6/13 PDB 3D structures from and Proteopedia for SKP1 (see all 13):

1FQV (3D)

1FS1 (3D)

1FS2 (3D)

1LDK (3D)

1P22 (3D)

2ASS (3D)

Secondary accessions: D3DQ97 D3DQ98 P34991 Q8TAY2

Alternative splicing: 2 isoforms: P63208-1, P34991-1 P63208-2, P34991-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKP1: NX_P63208

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P63208

SKP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_008861.2 NP_733779.1

ENSEMBL proteins:

ENSP00000231487 ENSP00000429472 ENSP00000431067 ENSP00000429961 ENSP00000429995

ENSP00000429686 ENSP00000331708 ENSP00000430885 ENSP00000429415 ENSP00000429996

ENSP00000430774 ENSP00000428962

Reactome Protein details: P63208
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SKP1 OriGene Protein Over-expression Lysate (see all 3): SKP1 OriGene Custom Protein Services for SKP1
	GenScript Custom Purified and Recombinant Proteins Services for SKP1
	Novus Biologicals SKP1 Proteins Novus Biologicals SKP1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SKP1
	Uscn Proteins for SKP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0019005	SCF ubiquitin ligase complex	IDA	--
GO:0031519	colocalizes with PcG protein complex	IDA	16943429

SKP1 for ontologies About GeneDecksing

SKP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SKP1 (SKP1A)
	OriGene Antibodies (see all 2): SKP1 OriGene Custom Antibody Services for SKP1
	GenScript Custom Superior Antibodies Services for SKP1
	Novus Biologicals SKP1 Antibodies
	Abcam antibodies for SKP1
	Uscn Antibodies for SKP1
	ThermoFisher Antibody for SKP1

Assay Products for SKP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SKP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SKP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SKP1 for domains About GeneDecksing

5 InterPro domains/families:

IPR016897 E3_ubiquit_lig_SCF_Skp

IPR001232 Skp1_comp

IPR011333 BTB/POZ_fold

IPR016072 Skp1_comp_dimer

IPR016073 Skp1_comp_POZ

Graphical View of Domain Structure for InterPro Entry P63208

ProtoNet protein and cluster: P63208

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208

Similarity: Belongs to the SKP1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208

Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the

ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF

complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at

'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to

activate transcription. SCF(Cyclin F) directs ubiquitination of CP110

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SKP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SKP1
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SKP1 (see all 56):
		hsa-miR-4328 hsa-miR-301a hsa-miR-371-5p hsa-miR-500a hsa-miR-3923 hsa-miR-374c hsa-miR-4330 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: SKP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SKP1 (see all 4) OriGene shRNA RFP: SKP1 OriGene siRNA: SKP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SKP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SKP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SKP1 (NM_006930)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SKP1
		Search LifeMap BioReagents cell lines for SKP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKP1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	--
GO:0005515	protein binding	IPI	--

SKP1 for ontologies About GeneDecksing

8 GenomeRNAi human phenotypes for SKP1:

Decreased Hepatitis C virus re	Decreased viability after Chla	Decreased viability of wild-ty	Decreased viability with pacli
Increased HPV18 LCR reporter a	Synthetic lethal with Ras	Synthetic lethal with imatinib	Upregulation of Wnt/beta-caten

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/16 pathways (see all 16)
Vpu mediated degradation of CD4	0.92	Signaling by Wnt	0.72
Degradation of ubiquitinated CD4	0.92	Degradation of ubiquitinated -beta catenin by the proteasome	0.72
SCF-mediated degradation of Emi1	0.87	Cyclin E associated events during G1/S transition	0.67
SCF-beta-TrCP mediated degradation of Emi1	0.87	Cyclin A:Cdk2-associated events at S phase entry	0.66

Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant

8/11 pathways (see all 11)
Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00	Signaling by NOTCH1	1.00
Signaling by NOTCH1 PEST Domain Mutants in Cancer	1.00	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.79
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	1.00	Signaling by NOTCH	0.77
Signaling by NOTCH1 in Cancer	1.00	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.71

FBXW7 WD mutants do not bind NICD1

Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	1.00	Prolactin receptor is internalized	0.25
FBXW7 WD mutants do not bind NICD1	1.00	Prolactin receptor signaling	0.18
p-NICD1 PEST domain mutants do not bind FBXW7	1.00	Nuclear signaling by ERBB4	0.07

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Cell cycle_Role of SCF complex in cell cycle regulation

Cell cycle_Role of SCF complex in cell cycle regulation

1.00

Cell cycle Role of SCF complex in cell cycle regulation

0.98

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for SKP1

	Cell cycle Regulation of G1/S transition (part 1)
	Cell cycle ESR1 regulation of G1/S transition
	Proteolysis Putative ubiquitin pathway
	Immune response MIF-JAB1 signaling
	Cell cycle Role of SCF complex in cell cycle regulation

1 Cell Signaling Technology (CST) Pathway for SKP1

Protein Stability

5 GeneGo (Thomson Reuters) Pathways for SKP1

	Cell cycle ESR1 regulation of G1/S transition
	Cell cycle Regulation of G1/S transition (part 1)
	Proteolysis Putative ubiquitin pathway
	Cell cycle Role of SCF complex in cell cycle regulation
	Immune response MIF-JAB1 signaling

5/7 BioSystems Pathways for SKP1 (see all 7)

	Delta-Notch Signaling Pathway
	TGF-beta Receptor Signaling Pathway
	Wnt Signaling Pathway NetPath
	TNF-alpha/NF-kB Signaling Pathway
	Notch signaling pathway

5/57 Reactome Pathways for SKP1 (see all 57)

	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	NOTCH1 Intracellular Domain Regulates Transcription
	SCF-beta-TrCP mediated degradation of Emi1
	FBXW7 Mutants and NOTCH1 in Cancer
	Prolactin receptor signaling

5/7 Kegg Pathways (Kegg details for SKP1) (see all 7):

	Cell cycle
	Oocyte meiosis
	Ubiquitin mediated proteolysis
	Protein processing in endoplasmic reticulum
	Wnt signaling pathway

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208

Pathway: Protein modification; protein ubiquitination

SKP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SKP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/384 Interacting proteins for SKP1 (P63208^{1, 2, 3} ENSP00000231487⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 384)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CUL1	Q13616¹^,²^,³, ENSP00000326804⁴	EBI-307486,EBI-359390 MINT-4304038 MINT-7305060 MINT-8399460 MINT-7305000 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=19 STRING: ENSP00000326804
SKP2	Q13309¹^,²^,³, ENSP00000274255⁴	EBI-307486,EBI-456291 MINT-14403 MINT-17351 MINT-7305110 MINT-7305092 MINT-1774079 MINT-6540206 I2D: score=9 STRING: ENSP00000274255
RBX1	P62877²^,³, ENSP00000216225⁴	MINT-8415355 MINT-18099 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=9 STRING: ENSP00000216225
ECD	O95905²^,³, ENSP00000401566⁴	MINT-7305074 MINT-7305092 MINT-7304971 I2D: score=1 STRING: ENSP00000401566
CDKN1A	P38936²^,³, ENSP00000244741⁴	MINT-1774098 MINT-1774140 I2D: score=1 STRING: ENSP00000244741

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000080	G1 phase of mitotic cell cycle	TAS	--
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006511	ubiquitin-dependent protein catabolic process	--	--

SKP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SKP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SKP1

5 DrugBank Compounds for SKP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2S)-2-(1H-indol-3-yl)hexanoic acid	--	--	target	--	10592235
(2S)-2-(1H-indol-3-yl)pentanoic acid	--	--	target	--	10592235
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid	--	--	target	--	10592235
1H-INDOL-3-YLACETIC ACID	--	--	target	--	10592235
Naphthalen-1-Yl-Acetic Acid	--	86-87-3	target	--	10592235

1 Novoseek chemical compound relationship for SKP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	0	1	12504026 (1)

Search CenterWatch for drugs/clinical trials and news about SKP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SKP1 gene (2 alternative transcripts):

NM_006930.3 NM_170679.2

Unigene Cluster for SKP1:

S-phase kinase-associated protein 1

Hs.171626 [show with all ESTs]

Unigene Representative Sequence: NM_006930

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000353411(uc003kzc.4 uc003kzd.4) ENST00000522552 ENST00000521216

ENST00000517691 ENST00000517625 ENST00000523966 ENST00000522855 ENST00000328392

ENST00000519054 ENST00000519321 ENST00000520417 ENST00000519718 ENST00000524288

ENST00000523359

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SKP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SKP1
		8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SKP1 (see all 56):
		hsa-miR-4328 hsa-miR-301a hsa-miR-371-5p hsa-miR-500a hsa-miR-3923 hsa-miR-374c hsa-miR-4330 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: SKP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SKP1 (see all 4) OriGene shRNA RFP: SKP1 OriGene siRNA: SKP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SKP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SKP1 (NM_006930)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SKP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKP1

Additional cDNA sequence:

AK057110.1 BC009839.2 BC020798.1 BC025673.1 BC065730.1 U33760.1 U37558.1 Z47087.1

24/66 DOTS entries (see all 66):

DT.100869237 DT.449717 DT.87016089 DT.101985983 DT.100873717 DT.95304030 DT.92467274 DT.100039519

DT.100696760 DT.100696751 DT.120801879 DT.92467303 DT.120801732 DT.100696762 DT.120801921 DT.120801910

DT.92467328 DT.100696749 DT.100696752 DT.100696763 DT.100696772 DT.120801883 DT.91993922 DT.95304017

24/1547 AceView cDNA sequences (see all 1547):

BG030711 BU688715 AA401725 BU163753 N35195 AW002694 CA976139 BM996371

CB994595 BM450423 BU183771 BQ417122 AL552713 BM708274 AA984964 BG199634

BI084047 CA775621 CA420838 CR617233 BM670641 CA944633 BU501504 BM711137

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SKP1 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7
SP1:							-		-				-								-
SP2:							-		-				-
SP3:									-				-
SP4:													-
SP5:							-		-

ECgene alternative splicing isoforms for SKP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SKP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAGTTTGA

About this image
See SKP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SKP1

SOURCE GeneReport for Unigene cluster: Hs.171626

SABiosciences Expression via Pathway-Focused PCR Arrays including SKP1:

Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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Ubiquitin Ligases in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SKP1 gene from 10/39 species (see all 39) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Skp1a^{1 , 5}	S-phase kinase-associated protein 1A^{1, 5}	94.48(n)¹ 99.39(a)¹		11 (31.86 cM)⁵ 21402¹ NM_011543.4¹ NP_035673.3¹ 52231995⁵
chicken (Gallus gallus)	Aves	SKP1¹	S-phase kinase-associated protein 1	88.55(n) 100(a)		416319 NM_001006153.1 NP_001006153.1
lizard (Anolis carolinensis)	Reptilia	SKP1⁶	--	100(a)	1 ↔ 1	2(130819346-130833477)
African clawed frog (Xenopus laevis)	Amphibia	skp1a-prov²	S-phase kinase-associated protein 1A (p19A)	82.72(n)		BC054184.1
zebrafish (Danio rerio)	Actinopterygii	zgc73186²	S-phase kinase-associated protein 1A	89.25(n)		393716 BC059536.1
fruit fly (Drosophila melanogaster)	Insecta	skpA¹	CG16983-PA	69.96(n) 77.16(a)		31016 NM_166861.2 NP_726695.1
worm (Caenorhabditis elegans)	Secernentea	skr-1¹	Protein SKR-1	65.62(n) 71.7(a)		172775 NM_060112.4 NP_492513.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SKP1(YDR328C)⁴ SKP1¹	Evolutionarily conserved kinetochore protein that is more⁴ Skp1p¹	58.12(n)¹ 55(a)¹		4(1126018-1125434)⁴ 851928^{1, 4} NP_010615.3¹ NP_010615.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	SKP1¹	S-phase kinase-associated protein 1	61.26(n) 60.39(a)		843928 NM_106245.4 NP_565123.1
rice (Oryza sativa)	Liliopsida	AK111678.1²	--	78.08(n)		AK111678.1

ENSEMBL Gene Tree for SKP1 (if available)
TreeFam Gene Tree for SKP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SKP1 gene

1 SIMAP similar gene for SKP1 using alignment to 9 protein entries: SKP1_HUMAN (see all proteins):

PPP2CB

SKP1 for paralogs About GeneDecksing

5/11 Pseudogenes.org Pseudogenes for SKP1 (see all 11)
PGOHUM00000238614 PGOHUM00000256661 PGOHUM00000239690 PGOHUM00000241050 PGOHUM00000245868

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78042489^1,2	F,	--	133491757(+)	`GTTGAG/AATTAC`	2	--	int¹		2		NA EA	240
rs140225658^1,2		--	133491918(+)	`GAAAAC/TAAGCT`	2	--	int¹		0	--	--	--	--
rs33989593^1,2	C,	--	133491932(+)	`CTCCT-/GAGA GAGAG`	2	--	int¹		0	--	--	--	--
rs72380905^1,2	C,	--	133491932(+)	`AGAGA-/GAGAGAG`	2	--	int¹		0	--	--	--	--
rs78078869^1,2	F,	--	133491948(+)	`AGAGAG/AAGAGA`	2	--	int¹		1		WA	118
rs56020717^1,2	C,	--	133492048(+)	`TTATAG/ATTTCC`	2	--	int¹		2		WA	120
rs17167326^1,2	C,F,H,	--	133492062(+)	`CTCTGG/CTACAG`	2	--	int¹		21		NA NS EA WA	2490
rs145528437^1,2		--	133492139(+)	`TGAAAA/GGTGAG`	2	--	ut3¹		0	--	--	--	--
rs57066510^1,2	C,	--	133492247(+)	`AAAAGC/GAAGGA`	2	--	ut3¹		2		WA	120
rs182079127^1,2		--	133492362(+)	`GCAGAC/GTAATT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SKP1 (133492082 - 133561762 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SKP1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SKP1 for disorders           About GeneDecksing

OMIM gene information: 601434    OMIM disorders: --

18 diseases for SKP1:    About MalaCards

coffin-lowry syndrome diffuse large b-cell lymphoma corneal staphyloma b-cell lymphomas

vitreoretinal dystrophy x inactivation oral squamous cell carcinoma squamous cell carcinoma

retinoschisis hearing loss myxoma laryngitis

laryngeal cancer parkinson's disease carcinoma hypoxia

malaria neuronitis

4 diseases from the University of Copenhagen DISEASES database for SKP1:

Retinoschisis Cancer Corneal staphyloma Coffin-Lowry syndrome

1 Novoseek disease relationship for SKP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	10430890 (1)

Human Genome Epidemiology (HuGE) Navigator: SKP1 (1 document)

Export disorders for SKP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SKP1 gene, integrated from 9 sources (see all 282):
(articles sorted by number of sources associating them with SKP1)

Utopia: connect your pdf to the dynamic
world of online information

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. (PubMed id 7553852)^{1, 2, 3} Zhang H.... Beach D. (1995)
Insights into SCF ubiquitin ligases from the structure of the Skp1- Skp2 complex. (PubMed id 11099048)^{1, 2, 9} Schulman B.A.... Pavletich N.P. (2000)
Chromosomal mapping of the genes for the human CDK2/c yclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PubMed id 8646875)^{1, 3, 9} Demetrick D.J....Beach D.H. (1996)
CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PubMed id 12481031)^{1, 2, 9} Dias D.C.... Pan Z.Q. (2002)
Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13- 12qter. (PubMed id 9031623)^{1, 2, 9} Liang Y.... Friedman T.B. (1997)
Structural basis of dimerization-dependent ubiquitina tion by the SCF(Fbx4) ubiquitin ligase. (PubMed id 20181953)^{1, 2} Li Y. and Hao B. (2010)
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)^{1, 2} Glenn K.A.... Paulson H.L. (2008)
Structure of a Fbw7-Skp1-cyclin E complex: multisite- phosphorylated substrate recognition by SCF ubiquitin ligases. (PubMed id 17434132)^{1, 2} Hao B....Pavletich N.P. (2007)
Structural basis for the selection of glycosylated su bstrates by SCF(Fbs1) ubiquitin ligase. (PubMed id 17389369)^{1, 2} Mizushima T....Tanaka K. (2007)
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. (PubMed id 16880511)^{1, 2} Sabile A....Krek W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6500	HGNC: 10899	AceView: SKP1A	Ensembl:ENSG00000113558	euGenes: HUgn6500
ECgene: SKP1	Kegg: 6500	H-InvDB: SKP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SKP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SKP1 gene
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Patent Information for SKP1 gene:
Search GeneIP for patents involving SKP1

GeneCards and IP:
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SKP1 Gene

S-phase kinase-associated protein 1

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SKP1 (Gene Symbol)
S-Phase Kinase-Associated Protein 1
OCP2
SKP1A
TCEB1L
EMC19
OCP-II
P19A
Cyclin-A/CDK2-Associated Protein P19
Organ Of Corti Protein 2
Organ Of Corti Protein II
Transcription Elongation Factor B
OCP-2
SIII
P19skp1
MGC34403
S-Phase Kinase-Associated Protein 1A (P19A)
Cyclin A/CDK2-Associated P19
Cyclin A/CDK2-Associated Protein P19
RNA Polymerase II Elongation Factor-Like Protein OCP2
RNA Polymerase II Elongation Factor-Like Protein

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SKP1 Gene

S-phase kinase-associated protein 1

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