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Aliases for SKP1 Gene

Aliases for SKP1 Gene

  • S-Phase Kinase Associated Protein 1 2 3 5
  • Transcription Elongation Factor B Polypeptide 1-Like 3 4
  • Cyclin-A/CDK2-Associated Protein P19 3 4
  • Organ Of Corti Protein II 3 4
  • Organ Of Corti Protein 2 3 4
  • P19skp1 3 4
  • OCP-II 3 4
  • TCEB1L 3 4
  • SKP1A 3 4
  • EMC19 3 4
  • OCP-2 3 4
  • SIII 3 4
  • OCP2 3 4
  • P19A 3 4
  • RNA Polymerase II Elongation Factor-Like Protein OCP2 3
  • RNA Polymerase II Elongation Factor-Like Protein 4
  • S-Phase Kinase-Associated Protein 1A (P19A) 2
  • S-Phase Kinase-Associated Protein 1 3
  • Cyclin A/CDK2-Associated P19 3

External Ids for SKP1 Gene

Previous HGNC Symbols for SKP1 Gene

  • SKP1A

Previous GeneCards Identifiers for SKP1 Gene

  • GC05M133521
  • GC05M128677
  • GC05M133484

Summaries for SKP1 Gene

Entrez Gene Summary for SKP1 Gene

  • This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for SKP1 Gene

SKP1 (S-Phase Kinase Associated Protein 1) is a Protein Coding gene. Diseases associated with SKP1 include Parkinson Disease 15, Autosomal Recessive. Among its related pathways are IL-1 signaling pathway and Notch signaling pathway (KEGG). GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000272772.

UniProtKB/Swiss-Prot for SKP1 Gene

  • Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Wiki entry for SKP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKP1 Gene

Genomics for SKP1 Gene

Regulatory Elements for SKP1 Gene

Enhancers for SKP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G134113 2 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +46.5 46513 34.1 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B YBX1 ZNF2 YY1 ZNF143 TCF7 C5orf24 VDAC1 SKP1 CDKL3 MTND4LP30 JADE2 CDKN2AIPNL SAR1B UBE2B
GH05G134289 0.9 ENCODE 16.9 -112.7 -112667 0.1 RB1 ARID4B ZNF2 THRB RAD21 RFX5 ZNF143 MIXL1 DEK ZNF654 SKP1 JADE2 PPP2CA ENSG00000248559 CDKN2AIPNL RPS10P11 DDX46 GC05P134270 ENSG00000273345
GH05G134174 1.1 ENCODE 11.3 +0.6 575 4.5 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 KLF13 SKP1 CDKN2AIPNL CAMLG MTND4LP30 PIR58605
GH05G134111 1.3 Ensembl ENCODE dbSUPER 9.5 +65.0 65029 1.3 HDGF PKNOX1 WRNIP1 FEZF1 EBF1 FOSL1 ZNF664 ZFHX2 EGR1 ZBTB48 SKP1 TCF7 LOC105379185
GH05G134244 1.5 Ensembl ENCODE dbSUPER 8.2 -69.6 -69645 4.4 FOXA2 SIN3A ZNF48 ZNF121 ZNF143 FOS CAVIN1 ZNF592 KAT8 MIER3 CDKN2AIPNL SKP1 RPS13P6 ENSG00000270177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SKP1 on UCSC Golden Path with GeneCards custom track

Promoters for SKP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187050 838 3201 FOXA2 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for SKP1 Gene

Chromosome:
5
Start:
134,148,935 bp from pter
End:
134,177,038 bp from pter
Size:
28,104 bases
Orientation:
Minus strand

Genomic View for SKP1 Gene

Genes around SKP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKP1 Gene

Proteins for SKP1 Gene

  • Protein details for SKP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63208-SKP1_HUMAN
    Recommended name:
    S-phase kinase-associated protein 1
    Protein Accession:
    P63208
    Secondary Accessions:
    • D3DQ97
    • D3DQ98
    • P34991
    • Q8TAY2

    Protein attributes for SKP1 Gene

    Size:
    163 amino acids
    Molecular mass:
    18658 Da
    Quaternary structure:
    • Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CEP68 (PubMed:25503564).

    Three dimensional structures from OCA and Proteopedia for SKP1 Gene

    Alternative splice isoforms for SKP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKP1 Gene

Post-translational modifications for SKP1 Gene

  • Ubiquitination at isoforms=2121, Lys137, Lys142, and Lys155
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SKP1 (SKP1A)

No data available for DME Specific Peptides for SKP1 Gene

Domains & Families for SKP1 Gene

Gene Families for SKP1 Gene

Protein Domains for SKP1 Gene

Suggested Antigen Peptide Sequences for SKP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63208

UniProtKB/Swiss-Prot:

SKP1_HUMAN :
  • Belongs to the SKP1 family.
Family:
  • Belongs to the SKP1 family.
genes like me logo Genes that share domains with SKP1: view

Function for SKP1 Gene

Molecular function for SKP1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at Lys-21 and Lys-22; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Ontology (GO) - Molecular Function for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS,IDA --
GO:0005515 protein binding IPI 11099048
GO:0008013 beta-catenin binding IDA 12820959
GO:0019904 protein domain specific binding IPI 15996101
GO:0061630 contributes_to ubiquitin protein ligase activity IDA 12820959
genes like me logo Genes that share ontologies with SKP1: view
genes like me logo Genes that share phenotypes with SKP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SKP1 Gene

Localization for SKP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18929646
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 18929646
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IDA 11956208
genes like me logo Genes that share ontologies with SKP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SKP1 Gene

Pathways & Interactions for SKP1 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Activated TLR4 signalling
3 Signaling by NOTCH1
4 HIV Life Cycle
.45
5 Cell cycle Role of SCF complex in cell cycle regulation
genes like me logo Genes that share pathways with SKP1: view

UniProtKB/Swiss-Prot P63208-SKP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SKP1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006879 cellular iron ion homeostasis TAS --
genes like me logo Genes that share ontologies with SKP1: view

Drugs & Compounds for SKP1 Gene

(6) Drugs for SKP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(1H-indol-3-yl)hexanoic acid Experimental Pharma Target 0
(2S)-2-(1H-indol-3-yl)pentanoic acid Experimental Pharma Target 0
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Experimental Pharma Target 0
1H-INDOL-3-YLACETIC ACID Experimental Pharma Target 0
Naphthalen-1-Yl-Acetic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with SKP1: view

Transcripts for SKP1 Gene

Unigene Clusters for SKP1 Gene

S-phase kinase-associated protein 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for SKP1 Gene

GeneLoc Exon Structure for
SKP1
ECgene alternative splicing isoforms for
SKP1

Expression for SKP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SKP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SKP1 Gene

This gene is overexpressed in Brain (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SKP1 Gene



Protein tissue co-expression partners for SKP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SKP1 Gene:

SKP1

SOURCE GeneReport for Unigene cluster for SKP1 Gene:

Hs.171626

Evidence on tissue expression from TISSUES for SKP1 Gene

  • Blood(4.8)
  • Liver(4.8)
  • Lung(4.8)
  • Nervous system(4.8)
  • Skin(4.5)
  • Muscle(3.8)
  • Pancreas(3.8)
  • Kidney(3.5)
  • Heart(2.6)
  • Eye(2.4)
  • Intestine(2.4)
  • Adrenal gland(2.3)
  • Thyroid gland(2.3)
  • Gall bladder(2.1)
  • Spleen(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SKP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKP1 Gene

Orthologs for SKP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SKP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKP1 34
  • 100 (n)
-- 35
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
ManyToMany
SKP1 34
  • 92.84 (n)
dog
(Canis familiaris)
Mammalia SKP1 34 35
  • 97.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Skp1a 34 16 35
  • 94.48 (n)
rat
(Rattus norvegicus)
Mammalia Skp1 34
  • 94.48 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SKP1 34 35
  • 88.55 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia skp1 34
  • 84.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia skp1a-prov 34
zebrafish
(Danio rerio)
Actinopterygii skp1 34 35
  • 84.05 (n)
zgc73186 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11291 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008719 34
  • 70.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta skpA 34 35
  • 69.96 (n)
skpB 35
  • 69 (a)
ManyToMany
skpC 35
  • 54 (a)
ManyToMany
skpF 35
  • 54 (a)
ManyToMany
skpD 35
  • 51 (a)
ManyToMany
skpE 35
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea skr-1 34 35
  • 65.2 (n)
skr-2 35
  • 56 (a)
ManyToMany
skr-3 35
  • 54 (a)
ManyToMany
skr-5 35
  • 53 (a)
ManyToMany
skr-4 35
  • 52 (a)
ManyToMany
skr-6 35
  • 45 (a)
ManyToMany
skr-12 35
  • 38 (a)
ManyToMany
skr-13 35
  • 38 (a)
ManyToMany
skr-10 35
  • 35 (a)
ManyToMany
skr-7 35
  • 35 (a)
ManyToMany
skr-8 35
  • 35 (a)
ManyToMany
skr-19 35
  • 34 (a)
ManyToMany
skr-9 35
  • 34 (a)
ManyToMany
skr-17 35
  • 33 (a)
ManyToMany
skr-14 35
  • 32 (a)
ManyToMany
skr-18 35
  • 30 (a)
ManyToMany
skr-20 35
  • 30 (a)
ManyToMany
skr-15 35
  • 29 (a)
ManyToMany
skr-16 35
  • 29 (a)
ManyToMany
skr-21 35
  • 25 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16941g 34
  • 61.6 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SKP1 34 35 37
  • 59.49 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR295C 34
  • 53.75 (n)
rice
(Oryza sativa)
Liliopsida Os11g0456300 34
  • 62.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11317 35
  • 90 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08991 34
  • 64.36 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes skp1 34
  • 57.02 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3812 34
Species where no ortholog for SKP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SKP1 Gene

ENSEMBL:
Gene Tree for SKP1 (if available)
TreeFam:
Gene Tree for SKP1 (if available)

Paralogs for SKP1 Gene

Variants for SKP1 Gene

Sequence variations from dbSNP and Humsavar for SKP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000175431 -- 134,161,607(+) ACTGA(C/T)ACTAA intron-variant
rs1000416790 -- 134,167,592(+) ATCTC(A/G)GCTCA intron-variant
rs1000510106 -- 134,163,137(+) TTGAG(C/T)CCAGG intron-variant
rs1000674601 -- 134,172,419(+) ACTGA(-/T)TTTGT intron-variant
rs1000737364 -- 134,156,585(+) GGAAG(A/G)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SKP1 Gene

Variant ID Type Subtype PubMed ID
nsv1126724 CNV deletion 24896259
nsv599732 CNV loss 21841781
nsv964939 CNV duplication 23825009

Variation tolerance for SKP1 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKP1 Gene

Disorders for SKP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SKP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease 15, autosomal recessive
  • autosomal recessive early-onset parkinson disease 15
- elite association - COSMIC cancer census association via MalaCards
Search SKP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SKP1

Genetic Association Database (GAD)
SKP1
Human Genome Epidemiology (HuGE) Navigator
SKP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKP1
genes like me logo Genes that share disorders with SKP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SKP1 Gene

Publications for SKP1 Gene

  1. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PMID: 12481031) Dias D.C. … Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 22 64
  2. Insights into SCF ubiquitin ligases from the structure of the Skp1- Skp2 complex. (PMID: 11099048) Schulman B.A. … Pavletich N.P. (Nature 2000) 3 4 22 64
  3. Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13- 12qter. (PMID: 9031623) Liang Y. … Friedman T.B. (Gene 1997) 3 4 22 64
  4. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PMID: 8646875) Demetrick D.J. … Beach D.H. (Cytogenet. Cell Genet. 1996) 2 3 22 64
  5. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. (PMID: 7553852) Zhang H. … Beach D. (Cell 1995) 2 3 4 64

Products for SKP1 Gene

Sources for SKP1 Gene

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