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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SKP1 Gene

protein-coding   GIFtS: 64
GCID: GC05M133521

S-Phase Kinase-Associated Protein 1

(Previous name: S-phase kinase-associated protein 1A (p19A))
(Previous symbol: SKP1A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
S-Phase Kinase-Associated Protein 11 2     OCP-II2 3
SKP1A1 2 3 5     SIII2 3
OCP22 3 5     p19A2 3
TCEB1L2 3 5     p19skp12 3
Cyclin-A/CDK2-Associated Protein P192 3     S-Phase Kinase-Associated Protein 1A (P19A)1
Organ Of Corti Protein 22 3     Cyclin A/CDK2-Associated P192
Organ Of Corti Protein II2 3     Cyclin A/CDK2-Associated Protein P192
Transcription Elongation Factor B2 3     RNA Polymerase II Elongation Factor-Like Protein OCP22
EMC192 3     RNA Polymerase II Elongation Factor-Like Protein3
OCP-22 3     

External Ids:    HGNC: 108991   Entrez Gene: 65002   Ensembl: ENSG000001135587   OMIM: 6014345   UniProtKB: P632083   

Export aliases for SKP1 gene to outside databases

Previous GC identifer: GC05M128677


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SKP1 Gene:
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein,
and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box
proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which
targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s),
and many specific SCF substrates have been identified including regulators of cell cycle progression and
development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative
splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome
7. (provided by RefSeq, Jul 2008)

GeneCards Summary for SKP1 Gene: 
SKP1 (S-phase kinase-associated protein 1) is a protein-coding gene. Diseases associated with SKP1 include corneal staphyloma, and vitreoretinal dystrophy, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Wnt Signaling Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and protein binding.

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the
ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF
complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex
depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination
of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.
SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11)
does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and
'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate
transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of
CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2

Gene Wiki entry for SKP1 (SKP1A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SKP1 gene promoter:
         Nkx3-1   S8   POU2F1   POU2F1a   Nkx3-1 v1   Pax-4a   Ik-1   GATA-2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SKP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

SKP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M133521:  view genomic region     (about GC identifiers)

Start:
133,484,633 bp from pter      End:
133,561,762 bp from pter
Size:
77,130 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208 (See protein sequence)
Recommended Name: S-phase kinase-associated protein 1  
Size: 163 amino acids; 18658 Da
Subunit: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1,
RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11)
complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly
with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32)
complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the
SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the
SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component
of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of
SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1,
SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the
SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1,
CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the
SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1,
SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the
SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7
6/14 PDB 3D structures from and Proteopedia for SKP1 (see all 14):
1FQV (3D)        1FS1 (3D)        1FS2 (3D)        1LDK (3D)        1P22 (3D)        2ASS (3D)    
Secondary accessions: D3DQ97 D3DQ98 P34991 Q8TAY2
Alternative splicing: 2 isoforms:  P63208-1, P34991-1   P63208-2, P34991-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKP1: NX_P63208

Explore proteomics data for SKP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P63208

  • SKP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SKP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_008861.2  NP_733779.1  

    ENSEMBL proteins: 
     ENSP00000231487   ENSP00000429472   ENSP00000431067   ENSP00000429961   ENSP00000429995  
     ENSP00000429686   ENSP00000331708   ENSP00000430885   ENSP00000429415   ENSP00000429996  
     ENSP00000430774   ENSP00000428962  
    Reactome Protein details: P63208
    Human Recombinant Protein Products for SKP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SKP1
    OriGene Protein Over-expression Lysate for SKP1
    OriGene MassSpec for SKP1 
    OriGene Custom Protein Services for SKP1
    GenScript Custom Purified and Recombinant Proteins Services for SKP1
    Novus Biologicals SKP1 Proteins
    Novus Biologicals SKP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SKP1
    Cloud-Clone Corp. Proteins for SKP1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0019005SCF ubiquitin ligase complex IDA15103331
    GO:0031467Cul7-RING ubiquitin ligase complex IDA--
    GO:0031519colocalizes with PcG protein complex IDA16943429

    SKP1 for ontologies           About GeneDecksing



    SKP1 Antibody Products: 
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    GenScript Custom Superior Antibodies Services for SKP1
    Novus Biologicals SKP1 Antibodies
    Abcam antibodies for SKP1
    Cloud-Clone Corp. Antibodies for SKP1 
    ThermoFisher Antibody for SKP1
    LSBio Antibodies in human, mouse, rat for SKP1 

    Assay Products for SKP1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SKP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SKP1 
    Cloud-Clone Corp. CLIAs for SKP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR016897 E3_ubiquit_lig_SCF_Skp
     IPR001232 Skp1_comp
     IPR011333 BTB/POZ_fold
     IPR016072 Skp1_comp_dimer
     IPR016073 Skp1_comp_POZ

    Graphical View of Domain Structure for InterPro Entry P63208

    ProtoNet protein and cluster: P63208

    UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208
    Similarity: Belongs to the SKP1 family


    SKP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKP1_HUMAN, P63208
    Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the
    ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF
    complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex
    depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination
    of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.
    SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
    SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
    transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
    and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
    probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
    SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11)
    does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and
    'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate
    transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of
    CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and TELO2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI11099048
         
    SKP1 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for SKP1:
     Decreased Hepatitis C virus re  Decreased viability after Chla  Decreased viability of wild-ty  Decreased viability with pacli 
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras  Synthetic lethal with imatinib  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SKP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SKP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SKP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SKP1
    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SKP1 (see all 56):
    hsa-miR-4328 hsa-miR-301a hsa-miR-371-5p hsa-miR-500a hsa-miR-3923 hsa-miR-374c hsa-miR-4330 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidSKP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SKP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SKP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SKP1
    Sirion Biotech Customized adenovirus for overexpression of SKP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SKP1 (see all 13)
    OriGene ORF clones in mouse, rat for SKP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SKP1 (NM_006930)
    Sino Biological Human cDNA Clone for SKP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKP1
    Sirion Biotech Customized lentivirus for stable overexpression of SKP1 
                         Customized lentivirus expression plasmids for stable overexpression of SKP1 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SKP1 About   (see all 34)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    3Circadian Clock
    Circadian Clock0.40
    Circadian rhythm0.35
    4CDK-mediated phosphorylation and removal of Cdc6
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cyclin E associated events during G1/S transition 0.89
    APC/C-mediated degradation of cell cycle proteins0.94
    Cyclin A:Cdk2-associated events at S phase entry0.88
    Regulation of mitotic cell cycle0.94
    S Phase0.79
    Vpu mediated degradation of CD40.92
    Degradation of beta-catenin by the destruction complex0.75
    5Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for SKP1
        Cell cycle Regulation of G1/S transition (part 1)
    Cell cycle ESR1 regulation of G1/S transition
    Proteolysis Putative ubiquitin pathway
    Immune response MIF-JAB1 signaling
    Cell cycle Role of SCF complex in cell cycle regulation


    1 Cell Signaling Technology (CST) Pathway for SKP1
        Protein Stability

    5 GeneGo (Thomson Reuters) Pathways for SKP1
        Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation
    Immune response MIF-JAB1 signaling

    5/7 BioSystems Pathways for SKP1 (see all 7)
        TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    TNF-alpha/NF-kB Signaling Pathway
    Delta-Notch Signaling Pathway
    Canonical Wnt signaling pathway


    5/47        Reactome Pathways for SKP1 (see all 47)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    SCF-beta-TrCP mediated degradation of Emi1
    FBXW7 Mutants and NOTCH1 in Cancer
    Prolactin receptor signaling


    5/8         Kegg Pathways  (Kegg details for SKP1) (see all 8):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Wnt signaling pathway

    UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208
    Pathway: Protein modification; protein ubiquitination


    SKP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SKP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/397 Interacting proteins for SKP1 (P632081, 2, 3 ENSP000002314874) via UniProtKB, MINT, STRING, and/or I2D (see all 397)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136161, 2, 3, ENSP000003268044EBI-307486,EBI-359390 MINT-4304038 MINT-7305060 MINT-8399460 MINT-7305000 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=19 STRING: ENSP00000326804
    BTRCQ9Y2971, 2, 3, ENSP000003592064EBI-307486,EBI-307461 MINT-16900 MINT-14391 MINT-14390 I2D: score=10 STRING: ENSP00000359206
    RBX1P628772, 3, ENSP000002162254MINT-8415355 MINT-18099 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=9 STRING: ENSP00000216225
    ECDO959052, 3, ENSP000004015664MINT-7305074 MINT-7305092 MINT-7304971 I2D: score=1 STRING: ENSP00000401566
    CDKN1AP389362, 3, ENSP000002447414MINT-1774098 MINT-1774140 I2D: score=1 STRING: ENSP00000244741
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007219Notch signaling pathway TAS--
    GO:0016032viral process TAS--

    SKP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SKP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SKP1

    5 DrugBank Compounds for SKP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(1H-indol-3-yl)hexanoic acid-- --target--10592235
    (2S)-2-(1H-indol-3-yl)pentanoic acid-- --target--10592235
    (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid-- --target--10592235
    1H-INDOL-3-YLACETIC ACID-- --target--10592235
    Naphthalen-1-Yl-Acetic Acid-- 86-87-3target--10592235

    1 Novoseek inferred chemical compound relationship for SKP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 0 1 12504026 (1)

    Search CenterWatch for drugs/clinical trials and news about SKP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SKP1 gene (2 alternative transcripts): 
    NM_006930.3  NM_170679.2  

    Unigene Cluster for SKP1:

    S-phase kinase-associated protein 1
    Hs.171626  [show with all ESTs]
    Unigene Representative Sequence: NM_006930
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353411(uc003kzc.4 uc003kzd.4) ENST00000522552 ENST00000521216
    ENST00000517691 ENST00000517625 ENST00000523966 ENST00000522855 ENST00000328392
    ENST00000519054 ENST00000519321 ENST00000520417 ENST00000519718 ENST00000524288
    ENST00000523359
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/56 QIAGEN miScript miRNA Assays for microRNAs that regulate SKP1 (see all 56):
    hsa-miR-4328 hsa-miR-301a hsa-miR-371-5p hsa-miR-500a hsa-miR-3923 hsa-miR-374c hsa-miR-4330 hsa-miR-130b
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    Additional mRNA sequence: 

    AK057110.1 BC009839.2 BC020798.1 BC025673.1 BC065730.1 U33760.1 U37558.1 Z47087.1 

    24/66 DOTS entries (see all 66):

    DT.100869237  DT.449717  DT.87016089  DT.101985983  DT.100873717  DT.95304030  DT.92467274  DT.100039519 
    DT.100696760  DT.100696751  DT.120801879  DT.92467303  DT.120801732  DT.100696762  DT.120801921  DT.120801910 
    DT.92467328  DT.100696749  DT.100696752  DT.100696763  DT.100696772  DT.120801883  DT.91993922  DT.95304017 

    24/1547 AceView cDNA sequences (see all 1547):

    CR617233 AA715316 BM352493 BQ632052 AI086935 AI367799 BM311131 CA430990 
    AI093034 AI262854 CB128877 CR602170 BI325058 AI866981 BM761161 BQ917266 
    AI199407 AI755122 BU542620 CB119283 AI865425 AI419410 BM677100 AW515304 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SKP1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                    -     -           -                       -         
    SP2:                    -     -           -                                 
    SP3:                          -           -                                 
    SP4:                                      -                                 
    SP5:                    -     -                                             


    ECgene alternative splicing isoforms for SKP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SKP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGTTTGA
    SKP1 Expression
    About this image


    See SKP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SKP1

    SOURCE GeneReport for Unigene cluster: Hs.171626
        SABiosciences Expression via Pathway-Focused PCR Arrays including SKP1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SKP1 gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skp1a1 , 5 S-phase kinase-associated protein 1A1, 5 94.48(n)1
    99.39(a)1
      11 (31.86 cM)5
    214021  NM_011543.41  NP_035673.31 
     522319955 
    chicken
    (Gallus gallus)
    Aves SKP11 S-phase kinase-associated protein 1 88.55(n)
    100(a)
      416319  NM_001006153.1  NP_001006153.1 
    lizard
    (Anolis carolinensis)
    Reptilia SKP16
    Uncharacterized protein
    100(a)
    1 ↔ 1
    2(130819318-130833477)
    African clawed frog
    (Xenopus laevis)
    Amphibia skp1a-prov2 S-phase kinase-associated protein 1A (p19A) 82.72(n)    BC054184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731862 S-phase kinase-associated protein 1A 89.25(n)   393716  BC059536.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta skpA1 CG16983-PA 69.96(n)
    77.16(a)
      31016  NM_166861.2  NP_726695.1 
    worm
    (Caenorhabditis elegans)
    Secernentea skr-11 Protein SKR-1 65.62(n)
    71.7(a)
      172775  NM_060112.4  NP_492513.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKP1(YDR328C)4
    SKP11
    Evolutionarily conserved kinetochore protein that is more4
    Skp1p1
    58.12(n)1
    55(a)1
      4(1126018-1125434)4
    8519281, 4  NP_010615.31  NP_010615.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SKP11 S-phase kinase-associated protein 1 61.26(n)
    60.39(a)
      843928  NM_106245.4  NP_565123.1 
    rice
    (Oryza sativa)
    Liliopsida AK111678.12   -- 78.08(n)    AK111678.1 


    ENSEMBL Gene Tree for SKP1 (if available)
    TreeFam Gene Tree for SKP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SKP1 gene
    1 SIMAP similar gene for SKP1 using alignment to 9 protein entries:     SKP1_HUMAN (see all proteins):
    PPP2CB

    SKP1 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for SKP1 (see all 11)
    PGOHUM00000238614 PGOHUM00000256661 PGOHUM00000239690 PGOHUM00000241050 PGOHUM00000245868


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/480 SNPs in SKP1 are shown (see all 480)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0519994
    ----see VAR_0519992 F L mis40--------
    rs780424891,2
    C,F--133491757(+) GTTGAG/AATTAC 2 -- int12Minor allele frequency- A:0.24NA EA 240
    rs1402256581,2
    --133491918(+) GAAAAC/TAAGCT 2 -- int10--------
    rs339895931,2
    C--133491932(+) CTCCT-/GAGA  
            
    GAGAG
    2 -- int10--------
    rs723809051,2
    C--133491932(+) AGAGA-/GA    
       
    /GAGA
    GAGAG
    2 -- int10--------
    rs780788691,2
    F--133491948(+) AGAGAG/AAGAGA 2 -- int11Minor allele frequency- A:0.05WA 118
    rs560207171,2
    C,F--133492048(+) TTATAG/ATTTCC 2 -- int12Minor allele frequency- A:0.21WA 120
    rs171673261,2
    C,F,H--133492062(+) CTCTGG/CTACAG 2 -- int121Minor allele frequency- C:0.12NA NS EA WA 2490
    rs1455284371,2
    --133492139(+) TGAAAA/GGTGAG 2 -- ut310--------
    rs570665101,2
    C,F--133492247(+) AAAAGC/GAAGGA 2 -- ut312Minor allele frequency- G:0.21WA 120

    HapMap Linkage Disequilibrium report for SKP1 (133484633 - 133561762 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SKP1: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601434    OMIM disorders: --

    20/21 diseases for SKP1 (see all 21):    About MalaCards
    corneal staphyloma    vitreoretinal dystrophy    glomuvenous malformation    coffin-lowry syndrome
    retinoschisis    hepatitis e    diffuse large b-cell lymphoma    laryngitis
    b-cell lymphomas    oral squamous cell carcinoma    parkinson's disease    multiple myeloma
    hypoxia    myeloma    squamous cell carcinoma    gastric cancer
    melanoma    endotheliitis    hepatitis    neuronitis

    5 diseases from the University of Copenhagen DISEASES database for SKP1:
    Retinoschisis     Cancer     Corneal staphyloma     Coffin-Lowry syndrome
    Vitreoretinal dystrophy

    SKP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SKP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 10430890 (1)

    Genetic Association Database (GAD): SKP1
    Human Genome Epidemiology (HuGE) Navigator: SKP1 (1 document)

    Export disorders for SKP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SKP1 gene, integrated from 9 sources (see all 311):
    (articles sorted by number of sources associating them with SKP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. (PubMed id 7553852)1, 2, 3 Zhang H.... Beach D. (1995)
    2. Insights into SCF ubiquitin ligases from the structure of the Skp1- Skp2 complex. (PubMed id 11099048)1, 2, 9 Schulman B.A.... Pavletich N.P. (2000)
    3. Chromosomal mapping of the genes for the human CDK2/c yclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PubMed id 8646875)1, 3, 9 Demetrick D.J....Beach D.H. (1996)
    4. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PubMed id 12481031)1, 2, 9 Dias D.C.... Pan Z.Q. (2002)
    5. Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13- 12qter. (PubMed id 9031623)1, 2, 9 Liang Y.... Friedman T.B. (1997)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Structural basis of dimerization-dependent ubiquitina tion by the SCF(Fbx4) ubiquitin ligase. (PubMed id 20181953)1, 2 Li Y. and Hao B. (2010)
    8. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2 Glenn K.A.... Paulson H.L. (2008)
    9. Structure of a Fbw7-Skp1-cyclin E complex: multisite- phosphorylated substrate recognition by SCF ubiquitin ligases. (PubMed id 17434132)1, 2 Hao B....Pavletich N.P. (2007)
    10. Structural basis for the selection of glycosylated su bstrates by SCF(Fbs1) ubiquitin ligase. (PubMed id 17389369)1, 2 Mizushima T....Tanaka K. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6500 HGNC: 10899 AceView: SKP1A Ensembl:ENSG00000113558 euGenes: HUgn6500
    ECgene: SKP1 Kegg: 6500 H-InvDB: SKP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SKP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SKP1 gene:
    Search GeneIP for patents involving SKP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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