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SKP1 Gene

protein-coding   GIFtS: 64
GCID: GC05M133484

S-Phase Kinase-Associated Protein 1

(Previous name: S-phase kinase-associated protein 1A (p19A))
(Previous symbol: SKP1A)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
S-Phase Kinase-Associated Protein 11 2     OCP-II2 3
SKP1A1 2 3 5     SIII2 3
OCP22 3 5     p19A2 3
TCEB1L2 3 5     p19skp12 3
Cyclin-A/CDK2-Associated Protein P192 3     S-Phase Kinase-Associated Protein 1A (P19A)1
Organ Of Corti Protein 22 3     Cyclin A/CDK2-Associated P192
Organ Of Corti Protein II2 3     Cyclin A/CDK2-Associated Protein P192
Transcription Elongation Factor B2 3     RNA Polymerase II Elongation Factor-Like Protein OCP22
EMC192 3     RNA Polymerase II Elongation Factor-Like Protein3
OCP-22 3     

External Ids:    HGNC: 108991   Entrez Gene: 65002   Ensembl: ENSG000001135587   OMIM: 6014345   UniProtKB: P632083   

Export aliases for SKP1 gene to outside databases

Previous GC identifers: GC05M133521 GC05M128677


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SKP1 Gene:
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein,
and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box
proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which
targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s),
and many specific SCF substrates have been identified including regulators of cell cycle progression and
development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative
splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome
7. (provided by RefSeq, Jul 2008)

GeneCards Summary for SKP1 Gene:
SKP1 (S-phase kinase-associated protein 1) is a protein-coding gene. Diseases associated with SKP1 include corneal staphyloma, and vitreoretinal dystrophy. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ENSG00000272772.

UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208
Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the
ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF
complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex
depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination
of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.
SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11)
directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the
ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to
translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110.
SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and
TELO2

Gene Wiki entry for SKP1 (SKP1A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the SKP1 gene promoter:
         Nkx3-1   S8   POU2F1   POU2F1a   Nkx3-1 v1   Pax-4a   Ik-1   GATA-2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKP1 promoter sequence
   Search Chromatin IP Primers for SKP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31

SKP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKP1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M133484:  view genomic region     (about GC identifiers)

Start:
133,484,633 bp from pter      End:
133,512,729 bp from pter
Size:
28,097 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208 (See protein sequence)
Recommended Name: S-phase kinase-associated protein 1  
Size: 163 amino acids; 18658 Da
Subunit: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1,
RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11)
complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly
with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32)
complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the
SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the
SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component
of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of
SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1,
SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the
SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1,
CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the
SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1,
SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the
SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7
Selected PDB 3D structures from and Proteopedia for SKP1 (see all 14):
1FQV (3D)        1FS1 (3D)        1FS2 (3D)        1LDK (3D)        1P22 (3D)        2ASS (3D)    
Secondary accessions: D3DQ97 D3DQ98 P34991 Q8TAY2
Alternative splicing: 2 isoforms:  P63208-1, P34991-1   P63208-2, P34991-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKP1: NX_P63208

Explore proteomics data for SKP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys121, Lys130, Lys137, Lys142, Lys155
  • Modification sites at PhosphoSitePlus

  • See SKP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_008861.2  NP_733779.1  

    ENSEMBL proteins: 
     ENSP00000231487   ENSP00000429472   ENSP00000431067   ENSP00000429961   ENSP00000429995  
     ENSP00000429686   ENSP00000331708   ENSP00000430885   ENSP00000429415   ENSP00000429996  
     ENSP00000428962  
    Reactome Protein details: P63208

    SKP1 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SKP1
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    OriGene MassSpec for SKP1
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    Novus Biologicals SKP1 Proteins
    Novus Biologicals SKP1 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SKP1
    Cloud-Clone Corp. Proteins for SKP1

    SKP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for SKP1 at Abcam
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    SKP1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SKP1
    Cloud-Clone Corp. CLIAs for SKP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001232 Skp1_comp
     IPR016072 Skp1_comp_dimer
     IPR016897 E3_ubiquit_lig_SCF_Skp
     IPR011333 BTB/POZ_fold
     IPR016073 Skp1_comp_POZ

    Graphical View of Domain Structure for InterPro Entry P63208

    ProtoNet protein and cluster: P63208

    UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208
    Similarity: Belongs to the SKP1 family


    SKP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKP1_HUMAN, P63208
    Function: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the
    ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF
    complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex
    depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination
    of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA.
    SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2.
    SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S
    transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC
    and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and
    probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1.
    SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11)
    directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the
    ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to
    translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110.
    SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) direct ubiquitination of TTI1 and
    TELO2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI11099048
         
    SKP1 for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for SKP1:
     Decreased Hepatitis C virus re  Decreased viability after Chla  Decreased viability of wild-ty  Decreased viability with pacli 
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras  Synthetic lethal with imatinib  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SKP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SKP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SKP1:
    hsa-mir-151a-5p (MIRT038197), hsa-mir-1301-3p (MIRT035977)

    Block miRNA regulation of human, mouse, rat SKP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SKP1 (see all 56):
    hsa-miR-4328 hsa-miR-301a hsa-miR-371-5p hsa-miR-500a hsa-miR-3923 hsa-miR-374c hsa-miR-4330 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidSKP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SKP1
    Predesigned siRNA for gene silencing in human, mouse, rat SKP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SKP1

    Clone
    Products:
         
    OriGene clones in human, mouse for SKP1 (see all 12)
    OriGene ORF clones in mouse, rat for SKP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SKP1 (NM_006930)
    Sino Biological Human cDNA Clone for SKP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKP1

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SKP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0019005SCF ubiquitin ligase complex IDA15103331
    GO:0031467Cul7-RING ubiquitin ligase complex IDA--
    GO:0031519colocalizes with PcG protein complex IDA16943429

    SKP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKP1 About   (see all 35)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    4CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Cyclin E associated events during G1/S transition0.86
    Regulation of mitotic cell cycle0.94
    Cyclin A-Cdk2-associated events at S phase entry0.85
    Regulation of APC/C activators between G1/S and early anaphase0.94
    S Phase0.78
    Vpu mediated degradation of CD40.92
    Activation of NF-kappaB in B Cells0.74
    5Regulation of PLK1 Activity at G2/M Transition
    Regulation of PLK1 Activity at G2/M Transition0.77
    Mitotic G2-G2/M phases0.69
    G2/M Transition0.70

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SKP1
        Protein Stability

    5 GeneGo (Thomson Reuters) Pathways for SKP1
        Cell cycle ESR1 regulation of G1/S transition
    Cell cycle Regulation of G1/S transition (part 1)
    Proteolysis Putative ubiquitin pathway
    Cell cycle Role of SCF complex in cell cycle regulation
    Immune response MIF-JAB1 signaling

    Selected BioSystems Pathways for SKP1 (see all 7)
        TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    Delta-Notch Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    Canonical Wnt signaling pathway


    Selected Reactome Pathways for SKP1 (see all 14)
        NOTCH1 Intracellular Domain Regulates Transcription
    SCF(Skp2)-mediated degradation of p27/p21
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
    SCF-beta-TrCP mediated degradation of Emi1


    Selected Kegg Pathways  (Kegg details for SKP1) (see all 8):
        Cell cycle
    Oocyte meiosis
    Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Wnt signaling pathway

    UniProtKB/Swiss-Prot: SKP1_HUMAN, P63208
    Pathway: Protein modification; protein ubiquitination


    SKP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SKP1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SKP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SKP1 (P632081, 2, 3 ENSP000002314874) via UniProtKB, MINT, STRING, and/or I2D (see all 563)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136161, 2, 3, ENSP000003268044EBI-307486,EBI-359390 MINT-4304038 MINT-7305060 MINT-8399460 MINT-7305000 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=19 STRING: ENSP00000326804
    BTRCQ9Y2971, 2, 3, ENSP000003592064EBI-307486,EBI-307461 MINT-16900 MINT-14391 MINT-14390 I2D: score=10 STRING: ENSP00000359206
    ECDO959051, 2, 3, ENSP000004015664EBI-307486,EBI-2557598 MINT-7305074 MINT-7305092 MINT-7304971 I2D: score=1 STRING: ENSP00000401566
    CDKN1AP389361, 2, 3, ENSP000002447414EBI-307486,EBI-375077 MINT-1774098 MINT-1774140 I2D: score=1 STRING: ENSP00000244741
    RBX1P628772, 3, ENSP000002162254MINT-8415355 MINT-18099 MINT-6804066 MINT-6540206 MINT-8198846 I2D: score=9 STRING: ENSP00000216225
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007219Notch signaling pathway TAS--

    SKP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SKP1

    5 DrugBank Compounds for SKP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(1H-indol-3-yl)hexanoic acid-- --target--10592235
    (2S)-2-(1H-indol-3-yl)pentanoic acid-- --target--10592235
    (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid-- --target--10592235
    1H-INDOL-3-YLACETIC ACID-- --target--10592235
    Naphthalen-1-Yl-Acetic Acid-- 86-87-3target--10592235

    1 Novoseek inferred chemical compound relationship for SKP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 0 1 12504026 (1)



    SKP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SKP1 gene (2 alternative transcripts): 
    NM_006930.3  NM_170679.2  

    Unigene Cluster for SKP1:

    S-phase kinase-associated protein 1
    Hs.171626  [show with all ESTs]
    Unigene Representative Sequence: NM_006930
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353411(uc003kzc.4 uc003kzd.4) ENST00000522552 ENST00000521216
    ENST00000517691 ENST00000517625 ENST00000523966 ENST00000522855 ENST00000328392
    ENST00000519054 ENST00000519321 ENST00000520417 ENST00000524288 ENST00000523359

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate SKP1 (see all 56):
    hsa-miR-4328 hsa-miR-301a hsa-miR-371-5p hsa-miR-500a hsa-miR-3923 hsa-miR-374c hsa-miR-4330 hsa-miR-130b
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    Additional mRNA sequence: 

    AK057110.1 BC009839.2 BC020798.1 BC025673.1 BC065730.1 U33760.1 U37558.1 Z47087.1 

    Selected DOTS entries (see all 66):

    DT.100869237  DT.449717  DT.87016089  DT.101985983  DT.100873717  DT.95304030  DT.92467274  DT.100039519 
    DT.100696760  DT.100696751  DT.120801879  DT.92467303  DT.120801732  DT.100696762  DT.120801921  DT.120801910 
    DT.92467328  DT.100696749  DT.100696752  DT.100696763  DT.100696772  DT.120801883  DT.91993922  DT.95304017 

    Selected AceView cDNA sequences (see all 1547):

    BQ417122 BM708274 AA984964 AL552713 BG199634 CA775621 BI084047 CA420838 
    CR617233 BM670641 CA944633 CB994595 BU163753 BU183771 BQ719864 BC020798 
    BU731364 BU955854 CR621165 AI400448 AJ713181 AI384136 AI372410 CD370490 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SKP1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                    -     -           -                       -         
    SP2:                    -     -           -                                 
    SP3:                          -           -                                 
    SP4:                                      -                                 
    SP5:                    -     -                                             


    ECgene alternative splicing isoforms for SKP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SKP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGTTTGA
    SKP1 Expression
    About this image


    SKP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    SKP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171626
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SKP1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SKP1 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skp1a1 , 5 S-phase kinase-associated protein 1A1, 5 94.48(n)1
    99.39(a)1
      11 (31.86 cM)5
    214021  NM_011543.41  NP_035673.31 
     522319955 
    chicken
    (Gallus gallus)
    Aves SKP11 S-phase kinase-associated protein 1 88.55(n)
    100(a)
      416319  NM_001006153.1  NP_001006153.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    100(a)
    1 → many
    2(130819318-130833477)
    African clawed frog
    (Xenopus laevis)
    Amphibia skp1a-prov2 S-phase kinase-associated protein 1A (p19A) 82.72(n)    BC054184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731862 S-phase kinase-associated protein 1A 89.25(n)   393716  BC059536.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta skpA1 skpA 69.96(n)
    77.16(a)
      31016  NM_166861.2  NP_726695.1 
    worm
    (Caenorhabditis elegans)
    Secernentea skr-11 skr-1 65.2(n)
    71.7(a)
      172775  NM_060112.5  NP_492513.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKP1(YDR328C)4
    SKP11
    Evolutionarily conserved kinetochore protein that is more4
    SKP11
    59.49(n)1
    56.96(a)1
      4(1126018-1125434)4
    8519281, 4  NP_010615.31  NP_010615.14 
    soybean
    (Glycine max)
    eudicotyledons 467220572   -- 77.14(n)  
    rice
    (Oryza sativa)
    Liliopsida AK111678.12   -- 78.08(n)    AK111678.1 


    ENSEMBL Gene Tree for SKP1 (if available)
    TreeFam Gene Tree for SKP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SKP1 gene
    ENSG000002727722  

    SKP1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for SKP1 (see all 11)
    PGOHUM00000238614 PGOHUM00000256661 PGOHUM00000239690 PGOHUM00000241050 PGOHUM00000245868


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SKP1 (see all 480)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780424891,2
    C,F--133491757(+) GTTGAG/AATTAC 2 -- int12Minor allele frequency- A:0.24NA EA 240
    rs1402256581,2
    --133491918(+) GAAAAC/TAAGCT 2 -- int10--------
    rs339895931,2
    C--133491932(+) CTCCT-/GAGA  
            
    GAGAG
    2 -- int10--------
    rs723809051,2
    C--133491932(+) AGAGA-/GA    
       
    /GAGA
    GAGAG
    2 -- int10--------
    rs780788691,2
    F--133491948(+) AGAGAG/AAGAGA 2 -- int11Minor allele frequency- A:0.05WA 118
    rs560207171,2
    C,F--133492048(+) TTATAG/ATTTCC 2 -- int12Minor allele frequency- A:0.21WA 120
    rs171673261,2
    C,F,H--133492062(+) CTCTGG/CTACAG 2 -- int121Minor allele frequency- C:0.12NA NS EA WA 2490
    rs1455284371,2
    --133492139(+) TGAAAA/GGTGAG 2 -- ut310--------
    rs570665101,2
    C,F--133492247(+) AAAAGC/GAAGGA 2 -- ut312Minor allele frequency- G:0.21WA 120
    rs1820791271,2
    --133492362(+) GCAGAC/GTAATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SKP1 (133484633 - 133512729 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SKP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SKP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SKP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601434    OMIM disorders: --

    Selected diseases for SKP1 (see all 25):    
    About MalaCards
    corneal staphyloma    vitreoretinal dystrophy    glomuvenous malformation    coffin-lowry syndrome
    retinoschisis    hepatitis e    diffuse large b-cell lymphoma    b-cell lymphomas
    vaccinia    laryngitis    oral squamous cell carcinoma    parkinson's disease
    myeloma    multiple myeloma    herpes simplex    hypoxia
    squamous cell carcinoma    hiv-1    melanoma    hepatitis

    5 diseases from the University of Copenhagen DISEASES database for SKP1:
    Retinoschisis     Cancer     Corneal staphyloma     Coffin-Lowry syndrome
    Vitreoretinal dystrophy

    SKP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SKP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 10430890 (1)

    Genetic Association Database (GAD): SKP1
    Human Genome Epidemiology (HuGE) Navigator: SKP1 (1 document)

    Export disorders for SKP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SKP1 gene, integrated from 10 sources (see all 320):
    (articles sorted by number of sources associating them with SKP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. (PubMed id 7553852)1, 2, 3 Zhang H.... Beach D. (Cell 1995)
    2. Insights into SCF ubiquitin ligases from the structure of the Skp1- Skp2 complex. (PubMed id 11099048)1, 2, 9 Schulman B.A.... Pavletich N.P. (Nature 2000)
    3. Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2). (PubMed id 8646875)1, 3, 9 Demetrick D.J....Beach D.H. (Cytogenet. Cell Genet. 1996)
    4. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PubMed id 12481031)1, 2, 9 Dias D.C.... Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13- 12qter. (PubMed id 9031623)1, 2, 9 Liang Y.... Friedman T.B. (Gene 1997)
    6. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. (PubMed id 22113614)1, 2 Duan S....Pagano M. (Nature 2012)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. (PubMed id 20181953)1, 2 Li Y. and Hao B. (J. Biol. Chem. 2010)
    9. Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases. (PubMed id 18203720)1, 2 Glenn K.A.... Paulson H.L. (J. Biol. Chem. 2008)
    10. Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. (PubMed id 17434132)1, 2 Hao B.... Pavletich N.P. (Mol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6500 HGNC: 10899 AceView: SKP1A Ensembl:ENSG00000113558 euGenes: HUgn6500
    ECgene: SKP1 Kegg: 6500 H-InvDB: SKP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SKP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SKP1 gene:
    Search GeneIP for patents involving SKP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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