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Aliases for SKOR2 Gene

Aliases for SKOR2 Gene

  • SKI Family Transcriptional Corepressor 2 2 3
  • Functional Smad-Suppressing Element On Chromosome 18 3 4
  • Ladybird Homeobox Corepressor 1-Like Protein 3 4
  • Functional Smad Suppressing Element 18 2 3
  • LBX1 Corepressor 1-Like Protein 3 4
  • Fussel-18 3 4
  • FUSSEL18 3 4
  • CORL2 3 4

External Ids for SKOR2 Gene

Previous GeneCards Identifiers for SKOR2 Gene

  • GC18M044729

Summaries for SKOR2 Gene

GeneCards Summary for SKOR2 Gene

SKOR2 (SKI Family Transcriptional Corepressor 2) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and histone deacetylase binding. An important paralog of this gene is SKI.

UniProtKB/Swiss-Prot for SKOR2 Gene

  • Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKOR2 Gene

Genomics for SKOR2 Gene

Genomic Location for SKOR2 Gene

Start:
47,206,694 bp from pter
End:
47,249,183 bp from pter
Size:
42,490 bases
Orientation:
Minus strand

Genomic View for SKOR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKOR2 Gene

No data available for Regulatory Elements for SKOR2 Gene

Proteins for SKOR2 Gene

  • Protein details for SKOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VWA4-SKOR2_HUMAN
    Recommended name:
    SKI family transcriptional corepressor 2
    Protein Accession:
    Q2VWA4
    Secondary Accessions:

    Protein attributes for SKOR2 Gene

    Size:
    1001 amino acids
    Molecular mass:
    104235 Da
    Quaternary structure:
    • Interacts with SMAD2 and SMAD3.

    Alternative splice isoforms for SKOR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKOR2 Gene

Proteomics data for SKOR2 Gene at MOPED

Post-translational modifications for SKOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKOR2 Gene

No data available for DME Specific Peptides for SKOR2 Gene

Domains for SKOR2 Gene

Gene Families for SKOR2 Gene

HGNC:
  • SKOR :SKI transcriptional corepressors

Suggested Antigen Peptide Sequences for SKOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2VWA4

UniProtKB/Swiss-Prot:

SKOR2_HUMAN :
  • Q2VWA4
Family:
  • Belongs to the SKI family.
genes like me logo Genes that share domains with SKOR2: view

Function for SKOR2 Gene

Molecular function for SKOR2 Gene

UniProtKB/Swiss-Prot Function: Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.

Gene Ontology (GO) - Molecular Function for SKOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity ISS --
GO:0042826 histone deacetylase binding --
GO:0046332 SMAD binding IPI 16200078
genes like me logo Genes that share ontologies with SKOR2: view
genes like me logo Genes that share phenotypes with SKOR2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SKOR2 Gene

Localization for SKOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKOR2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKOR2 Gene COMPARTMENTS Subcellular localization image for SKOR2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SKOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16200078
GO:0005737 cytoplasm IDA 16200078
genes like me logo Genes that share ontologies with SKOR2: view

Pathways for SKOR2 Gene

SuperPathways for SKOR2 Gene

No Data Available

Interacting Proteins for SKOR2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000414750%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000359212%0d%0a
Selected Interacting proteins: ENSP00000414750 Q2VWA4-SKOR2_HUMAN for SKOR2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SKOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 16200078
GO:0021587 cerebellum morphogenesis --
GO:0021702 cerebellar Purkinje cell differentiation --
genes like me logo Genes that share ontologies with SKOR2: view

No data available for Pathways by source for SKOR2 Gene

Transcripts for SKOR2 Gene

mRNA/cDNA for SKOR2 Gene

(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SKOR2 Gene

No ASD Table

Relevant External Links for SKOR2 Gene

GeneLoc Exon Structure for
SKOR2
ECgene alternative splicing isoforms for
SKOR2

Expression for SKOR2 Gene

mRNA expression in normal human tissues for SKOR2 Gene

mRNA differential expression in normal tissues according to GTEx for SKOR2 Gene

This gene is overexpressed in Testis (26.0), Brain - Spinal cord (cervical c-1) (9.9), Brain - Cerebellum (9.1), and Brain - Hypothalamus (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SKOR2 Gene

mRNA Expression by UniProt/SwissProt for SKOR2 Gene

Q2VWA4-SKOR2_HUMAN
Tissue specificity: Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level).
genes like me logo Genes that share expressions with SKOR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SKOR2 Gene

Orthologs for SKOR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SKOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKOR2 35
  • 96.6 (n)
  • 96.09 (a)
SKOR2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKOR2 35
  • 89.69 (n)
  • 92.81 (a)
SKOR2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKOR2 35
  • 91.48 (n)
  • 93 (a)
SKOR2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skor2 35
  • 85.5 (n)
  • 90.67 (a)
Skor2 16
Skor2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKOR2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Skor2 35
  • 85.5 (n)
  • 90.76 (a)
chicken
(Gallus gallus)
Aves SKOR2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKOR2 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SKOR2 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11093 36
  • 31 (a)
OneToMany
Species with no ortholog for SKOR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKOR2 Gene

ENSEMBL:
Gene Tree for SKOR2 (if available)
TreeFam:
Gene Tree for SKOR2 (if available)

Paralogs for SKOR2 Gene

Paralogs for SKOR2 Gene

Selected SIMAP similar genes for SKOR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SKOR2: view

Variants for SKOR2 Gene

Sequence variations from dbSNP and Humsavar for SKOR2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs938134 -- 47,225,003(+) CTGCC(A/G)CCCCG intron-variant
rs1025562 -- 47,213,606(+) AAAAA(A/C)AGGAC intron-variant
rs1025563 -- 47,213,632(+) ATCTC(A/G)CTATT intron-variant
rs1355593 -- 47,220,089(-) GACTG(A/T)CAATA intron-variant
rs1355594 -- 47,237,623(+) AAAGA(G/T)CAAAA intron-variant

Relevant External Links for SKOR2 Gene

HapMap Linkage Disequilibrium report
SKOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SKOR2 Gene

Disorders for SKOR2 Gene

Relevant External Links for SKOR2

Genetic Association Database (GAD)
SKOR2
Human Genome Epidemiology (HuGE) Navigator
SKOR2
genes like me logo Genes that share disorders with SKOR2: view

No data available for UniProtKB/Swiss-Prot for SKOR2 Gene

Publications for SKOR2 Gene

  1. Cloning and functional characterization of a new Ski homolog, Fussel- 18, specifically expressed in neuronal tissues. (PMID: 16200078) Arndt S. … Bosserhoff A.-K. (Lab. Invest. 2005) 2 3 4
  2. Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker. (PMID: 18522874) Minaki Y. … Ono Y. (Gene Expr. Patterns 2008) 2 3
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 4

Products for SKOR2 Gene

Sources for SKOR2 Gene

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