Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SKOR2 Gene

Aliases for SKOR2 Gene

  • SKI Family Transcriptional Corepressor 2 2 3 5
  • Functional Smad-Suppressing Element On Chromosome 18 3 4
  • Ladybird Homeobox Corepressor 1-Like Protein 3 4
  • Functional Smad Suppressing Element 18 2 3
  • LBX1 Corepressor 1-Like Protein 3 4
  • Fussel-18 3 4
  • FUSSEL18 3 4
  • CORL2 3 4
  • CH18515 3

External Ids for SKOR2 Gene

Previous GeneCards Identifiers for SKOR2 Gene

  • GC18M044729

Summaries for SKOR2 Gene

GeneCards Summary for SKOR2 Gene

SKOR2 (SKI Family Transcriptional Corepressor 2) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is SKI.

UniProtKB/Swiss-Prot for SKOR2 Gene

  • Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKOR2 Gene

Genomics for SKOR2 Gene

Regulatory Elements for SKOR2 Gene

Enhancers for SKOR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SKOR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SKOR2 Gene

47,206,203 bp from pter
47,249,630 bp from pter
43,428 bases
Minus strand

Genomic View for SKOR2 Gene

Genes around SKOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKOR2 Gene

Proteins for SKOR2 Gene

  • Protein details for SKOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SKI family transcriptional corepressor 2
    Protein Accession:

    Protein attributes for SKOR2 Gene

    1001 amino acids
    Molecular mass:
    104235 Da
    Quaternary structure:
    • Interacts with SMAD2 and SMAD3.

    Alternative splice isoforms for SKOR2 Gene


neXtProt entry for SKOR2 Gene

Proteomics data for SKOR2 Gene at MOPED

Post-translational modifications for SKOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKOR2 Gene

No data available for DME Specific Peptides for SKOR2 Gene

Domains & Families for SKOR2 Gene

Gene Families for SKOR2 Gene

Suggested Antigen Peptide Sequences for SKOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SKI family.
  • Belongs to the SKI family.
genes like me logo Genes that share domains with SKOR2: view

Function for SKOR2 Gene

Molecular function for SKOR2 Gene

UniProtKB/Swiss-Prot Function:
Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.
genes like me logo Genes that share phenotypes with SKOR2: view

Animal Models for SKOR2 Gene

MGI Knock Outs for SKOR2:

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SKOR2 Gene

Localization for SKOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKOR2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for SKOR2 Gene COMPARTMENTS Subcellular localization image for SKOR2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SKOR2 Gene

Pathways & Interactions for SKOR2 Gene

SuperPathways for SKOR2 Gene

No Data Available

Interacting Proteins for SKOR2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000414750 Q2VWA4-SKOR2_HUMAN for SKOR2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SKOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 16200078
GO:0021587 cerebellum morphogenesis IEA --
GO:0021702 cerebellar Purkinje cell differentiation IEA --
GO:0021936 regulation of cerebellar granule cell precursor proliferation IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with SKOR2: view

No data available for Pathways by source and SIGNOR curated interactions for SKOR2 Gene

Drugs & Compounds for SKOR2 Gene

No Compound Related Data Available

Transcripts for SKOR2 Gene

mRNA/cDNA for SKOR2 Gene

(3) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SKOR2 Gene

No ASD Table

Relevant External Links for SKOR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SKOR2 Gene

mRNA expression in normal human tissues for SKOR2 Gene

mRNA differential expression in normal tissues according to GTEx for SKOR2 Gene

This gene is overexpressed in Testis (x26.0), Brain - Spinal cord (cervical c-1) (x9.9), Brain - Cerebellum (x9.1), and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for SKOR2 Gene

This gene is overexpressed in Platelet (41.9), Peripheral blood mononuclear cells (13.9), and Adipocyte (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SKOR2 Gene

mRNA Expression by UniProt/SwissProt for SKOR2 Gene

Tissue specificity: Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at protein level).
genes like me logo Genes that share expression patterns with SKOR2: view

Protein tissue co-expression partners for SKOR2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SKOR2 Gene

Orthologs for SKOR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SKOR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SKOR2 35
  • 89.69 (n)
  • 92.81 (a)
SKOR2 36
  • 82 (a)
(Canis familiaris)
Mammalia SKOR2 35
  • 91.48 (n)
  • 93 (a)
SKOR2 36
  • 78 (a)
(Mus musculus)
Mammalia Skor2 35
  • 85.5 (n)
  • 90.67 (a)
Skor2 16
Skor2 36
  • 91 (a)
(Pan troglodytes)
Mammalia SKOR2 35
  • 96.6 (n)
  • 96.09 (a)
SKOR2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Skor2 35
  • 85.5 (n)
  • 90.76 (a)
(Monodelphis domestica)
Mammalia SKOR2 36
  • 78 (a)
(Gallus gallus)
Aves SKOR2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia SKOR2 36
  • 61 (a)
(Danio rerio)
Actinopterygii SKOR2 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11093 36
  • 31 (a)
Species with no ortholog for SKOR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKOR2 Gene

Gene Tree for SKOR2 (if available)
Gene Tree for SKOR2 (if available)

Paralogs for SKOR2 Gene

Paralogs for SKOR2 Gene

(1) SIMAP similar genes for SKOR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SKOR2: view

Variants for SKOR2 Gene

Sequence variations from dbSNP and Humsavar for SKOR2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs7235231 - 47,230,536(+) GTTCA(A/C)ATAAA reference, missense
rs8086549 -- 47,230,050(+) CTATC(A/C)GGAAC intron-variant
rs7236105 -- 47,230,855(+) TGGTG(G/T)AGAAC intron-variant, downstream-variant-500B
rs1836259 -- 47,206,018(+) CCAAA(C/G)GCTGG downstream-variant-500B
rs9950812 -- 47,239,572(+) AGTGC(A/G)TCTCG intron-variant

Variation tolerance for SKOR2 Gene

Gene Damage Index Score: 8.50; 85.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for SKOR2 Gene

Disorders for SKOR2 Gene

Relevant External Links for SKOR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SKOR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKOR2 Gene

Publications for SKOR2 Gene

  1. Cloning and functional characterization of a new Ski homolog, Fussel- 18, specifically expressed in neuronal tissues. (PMID: 16200078) Arndt S. … Bosserhoff A.-K. (Lab. Invest. 2005) 2 3 4 67
  2. Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker. (PMID: 18522874) Minaki Y. … Ono Y. (Gene Expr. Patterns 2008) 2 3
  3. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  5. HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. (PMID: 20029986) Bennett K.L. … Eng C. (Genes Chromosomes Cancer 2010) 3

Products for SKOR2 Gene

Sources for SKOR2 Gene