SKOR2 Gene
protein-coding GIFtS: 32
GCID: GC18M044729
|
|
SKI family transcriptional corepressor 2
| |
Aliases
for SKOR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SKI Family Transcriptional Corepressor 21 2 | | Ladybird Homeobox Corepressor 1-Like Protein2 3 | | CORL21 2 3 | | LBX1 Corepressor 1-Like Protein2 3 | | FUSSEL181 2 3 | | Functional Smad Suppressing Element 182 | | Fussel-181 3 | | Fussel-181 3 | | Functional Smad-Suppressing Element On Chromosome 182 3 | | |
Export aliases for SKOR2 gene to outside databases |
Summaries
for SKOR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SKOR2_HUMAN, Q2VWA4Function: Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervoussystem
|
Genomic Views
for SKOR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SKOR2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SKOR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKOR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q21.1 Ensembl cytogenetic band: 18q21.1 HGNC cytogenetic band: 18q21.1SKOR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M044729: view genomic region
(about GC identifiers)
Start:
|
44,746,293 bp from pter |
End:
|
44,775,554 bp from pter |
Size:
|
29,262 bases |
Orientation:
|
minus strand |
|
Proteins
for SKOR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SKOR2_HUMAN, Q2VWA4 (See
protein sequence)Recommended Name: SKI family transcriptional corepressor 2 Size: 1001 amino acids; 104235 Da
Subunit: Interacts with SMAD2 and SMAD3
Subcellular location: Nucleus. CytoplasmAlternative splicing: 2 isoforms: Q2VWA4-1 Q2VWA4-2 Explore the universe of human proteins at neXtProt for SKOR2: NX_Q2VWA4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2VWA4
SKOR2 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000414750 ENSP00000383255
Human Recombinant Protein Products for SKOR2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SKOR2 for ontologies About GeneDecksing
SKOR2 Antibody Products:
Assay Products for SKOR2: |
Protein
Domains /
Families
for SKOR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SKOR2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2VWA4ProtoNet protein and cluster: Q2VWA4 2 Blocks protein families: IPB000770 SAND domain IPB010919 SAND-like
UniProtKB/Swiss-Prot: SKOR2_HUMAN, Q2VWA4Similarity: Belongs to the SKI family |
Function
for SKOR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SKOR2_HUMAN, Q2VWA4Function: Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervoussystem Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SKOR2 for ontologies About GeneDecksing
Phenotypes:
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Skor2):
SKOR2 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SKOR2 (XM_001715219) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SKOR2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SKOR2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKOR2 |
|
Pathways & Interactions
for SKOR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SKOR2
5/13 Interacting proteins for SKOR2 (Q2VWA43) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IBA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 16200078 | | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
IDA | 16200078 |
SKOR2 for ontologies About GeneDecksing
|
Drugs & Compounds
for SKOR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SKOR2
Search CenterWatch for drugs/clinical trials and news about SKOR2
|
Transcripts
for SKOR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SKOR2 gene: NM_001037802.1 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000425639 ENST00000400404(uc010dnt.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SKOR2 (XM_001715219) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SKOR2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SKOR2 |
GeneLoc Exon Structure
|
Expression
for SKOR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SKOR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SKOR2 Protein Expression from SPIRE MOPED and PaxDB UniProtKB/Swiss-Prot: SKOR2_HUMAN, Q2VWA4Tissue specificity: Expressed in cerebellum, spinal cord and testis. Isoform 2 is present in cerebellum (at proteinlevel)
SABiosciences Custom PCR Arrays for SKOR2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKOR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SKOR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKOR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKOR2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKOR2 |
Orthologs
for SKOR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SKOR2 gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SKOR21 |
SKI family transcriptional corepressor 2 |
75.01(n)
77.92(a) |
|
770237 XM_001233569.2 XP_001233570.2 |
lizard
(Anolis carolinensis) |
Reptilia |
SKOR26 |
-- |
59(a) |
1 ↔ 1 |
1(34262174-34304214) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1533956 |
zgc:153395 |
58(a) |
1 ↔ 1 |
10(14576488-14586634) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG110936 |
-- |
26(a) |
1 → many |
4(982967-999048) |
ENSEMBL Gene Tree for SKOR2 (if available)
TreeFam Gene Tree for SKOR2 (if available) |
Paralogs
for SKOR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SKOR2 gene
- SKI2 SKIL2 SKOR12
1 SIMAP similar gene for SKOR2 using alignment to 1 protein entry: SKOR2_HUMAN:SKI
SKOR2 for paralogs About GeneDecksing
|
Genomic Variants
for SKOR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SKOR2 (44746293 - 44775554 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SKOR2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SKOR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SKOR2 for disorders About GeneDecksing
2  diseases for SKOR2: About MalaCardsneuronitis alcoholism
Human Genome Epidemiology (HuGE) Navigator: SKOR2 (1 document)
Export disorders for SKOR2 gene to outside databases
|
Publications
for SKOR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SKOR2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SKOR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues. (PubMed id 16200078)1, 2, 3 Arndt S....Bosserhoff A.K. (2005)
- Identification of a novel transcriptional corepressor , Corl2, as a cerebellar Purkinje cell-selective marker. (PubMed id 18522874)1, 3 Minaki Y....Ono Y. (2008)
- HPV status-independent association of alcohol and tob acco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinom as. (PubMed id 20029986)1 Bennett K.L....Eng C. (2010)
- Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1 Elks C.E....Murray A. (2010)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
|
External Searches for SKOR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SKOR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SKOR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SKOR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SKOR2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SKOR2 gene:
Search GeneIP for patents involving SKOR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SKOR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SKOR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SKOR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKOR2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SKOR2 | | OriGene Custom Protein Services for SKOR2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SKOR2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SKOR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKOR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SKOR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKOR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKOR2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SKOR2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SKOR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKOR2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SKOR2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SKOR2 |
| |  | |
|
|
|
