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Aliases for SKOR1 Gene

Aliases for SKOR1 Gene

  • SKI Family Transcriptional Corepressor 1 2 3
  • Functional Smad-Suppressing Element On Chromosome 15 3 4
  • Functional Smad Suppressing Element 15 2 3
  • Transcriptional Corepressor CORL1 2 3
  • Ladybird Homeobox Corepressor 1 3 4
  • Corepressor For LBX1 2 3
  • LBX1 Corepressor 1 3 4
  • Fussel-15 3 4
  • FUSSEL15 3 4
  • LBXCOR1 3 4
  • CORL1 3 4
  • Lbxcor1 Homolog (Mouse) 2
  • Lbxcor1 Homolog 3

External Ids for SKOR1 Gene

Previous HGNC Symbols for SKOR1 Gene

  • LBXCOR1

Previous GeneCards Identifiers for SKOR1 Gene

  • GC15P068113
  • GC15P044951

Summaries for SKOR1 Gene

GeneCards Summary for SKOR1 Gene

SKOR1 (SKI Family Transcriptional Corepressor 1) is a Protein Coding gene. GO annotations related to this gene include transcription corepressor activity and SMAD binding. An important paralog of this gene is SKI.

UniProtKB/Swiss-Prot for SKOR1 Gene

  • Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKOR1 Gene

Genomics for SKOR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SKOR1 Gene

Chromosome:
15
Start:
67,819,704 bp from pter
End:
67,834,561 bp from pter
Size:
14,858 bases
Orientation:
Plus strand

Genomic View for SKOR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKOR1 Gene

No data available for Regulatory Elements for SKOR1 Gene

Proteins for SKOR1 Gene

  • Protein details for SKOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84550-SKOR1_HUMAN
    Recommended name:
    SKI family transcriptional corepressor 1
    Protein Accession:
    P84550
    Secondary Accessions:
    • A6NIP4
    • A6NJY0
    • Q2VWA5

    Protein attributes for SKOR1 Gene

    Size:
    965 amino acids
    Molecular mass:
    99831 Da
    Quaternary structure:
    • Interacts with LBX1 (By similarity). Interacts with SMAD1, SMAD2 and SMAD3.

    Alternative splice isoforms for SKOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKOR1 Gene

Proteomics data for SKOR1 Gene at MOPED

Post-translational modifications for SKOR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKOR1 Gene

No data available for DME Specific Peptides for SKOR1 Gene

Domains & Families for SKOR1 Gene

Gene Families for SKOR1 Gene

Suggested Antigen Peptide Sequences for SKOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P84550

UniProtKB/Swiss-Prot:

SKOR1_HUMAN :
  • Belongs to the SKI family.
Family:
  • Belongs to the SKI family.
genes like me logo Genes that share domains with SKOR1: view

Function for SKOR1 Gene

Molecular function for SKOR1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.

Gene Ontology (GO) - Molecular Function for SKOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding --
GO:0046332 SMAD binding IPI 17292623
genes like me logo Genes that share ontologies with SKOR1: view

Phenotypes for SKOR1 Gene

GenomeRNAi human phenotypes for SKOR1:
genes like me logo Genes that share phenotypes with SKOR1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SKOR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SKOR1 Gene

Localization for SKOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKOR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKOR1 Gene COMPARTMENTS Subcellular localization image for SKOR1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for SKOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 17292623
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IBA --
GO:0030425 dendrite IDA 17292623
GO:0043025 neuronal cell body IDA 17292623
genes like me logo Genes that share ontologies with SKOR1: view

Pathways & Interactions for SKOR1 Gene

SuperPathways for SKOR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SKOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 17292623
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IBA --
GO:0030514 negative regulation of BMP signaling pathway IDA 17292623
genes like me logo Genes that share ontologies with SKOR1: view

No data available for Pathways by source and SIGNOR curated interactions for SKOR1 Gene

Drugs & Compounds for SKOR1 Gene

No Compound Related Data Available

Transcripts for SKOR1 Gene

mRNA/cDNA for SKOR1 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SKOR1 Gene

SKI family transcriptional corepressor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SKOR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKOR1 Gene

No ASD Table

Relevant External Links for SKOR1 Gene

GeneLoc Exon Structure for
SKOR1
ECgene alternative splicing isoforms for
SKOR1

Expression for SKOR1 Gene

mRNA expression in normal human tissues for SKOR1 Gene

mRNA differential expression in normal tissues according to GTEx for SKOR1 Gene

This gene is overexpressed in Brain - Cerebellum (x7.4) and Brain - Cerebellar Hemisphere (x5.2).

Protein differential expression in normal tissues from HIPED for SKOR1 Gene

This gene is overexpressed in Liver (50.6) and Heart (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SKOR1 Gene



SOURCE GeneReport for Unigene cluster for SKOR1 Gene Hs.451224

mRNA Expression by UniProt/SwissProt for SKOR1 Gene

P84550-SKOR1_HUMAN
Tissue specificity: Present specifically in cerebellar Purkinje cells (at protein level).
genes like me logo Genes that share expression patterns with SKOR1: view

Protein tissue co-expression partners for SKOR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SKOR1 Gene

Orthologs for SKOR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SKOR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SKOR1 35
  • 84.32 (n)
  • 83.92 (a)
SKOR1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKOR1 35
  • 92.7 (n)
  • 94.56 (a)
SKOR1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SKOR1 35
  • 99.16 (n)
  • 98.85 (a)
SKOR1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKOR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skor1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKOR1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia skor1 35
  • 71.67 (n)
  • 73 (a)
Str.13154 35
zebrafish
(Danio rerio)
Actinopterygii skor1a 36
  • 54 (a)
OneToMany
skor1b 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11093 36
  • 28 (a)
OneToMany
Species with no ortholog for SKOR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKOR1 Gene

ENSEMBL:
Gene Tree for SKOR1 (if available)
TreeFam:
Gene Tree for SKOR1 (if available)

Paralogs for SKOR1 Gene

Paralogs for SKOR1 Gene

(1) SIMAP similar genes for SKOR1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SKOR1: view

Variants for SKOR1 Gene

Sequence variations from dbSNP and Humsavar for SKOR1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs922493 -- 67,818,410(+) TACCT(A/G)CTAAG upstream-variant-2KB
rs922494 -- 67,828,306(+) GAAAC(C/T)GGGCC intron-variant
rs1871308 -- 67,819,100(+) ctctc(C/T)ctcca upstream-variant-2KB
rs1871309 -- 67,819,104(+) ccctc(C/T)atata upstream-variant-2KB
rs2061845 -- 67,819,936(+) GCCGC(C/T)GCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKOR1 Gene

Variant ID Type Subtype PubMed ID
nsv827375 CNV Gain 20364138
nsv1578 CNV Insertion 18451855

Variation tolerance for SKOR1 Gene

Residual Variation Intolerance Score: 29.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKOR1 Gene

HapMap Linkage Disequilibrium report
SKOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKOR1 Gene

Disorders for SKOR1 Gene

Relevant External Links for SKOR1

Human Genome Epidemiology (HuGE) Navigator
SKOR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKOR1
genes like me logo Genes that share disorders with SKOR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKOR1 Gene

Publications for SKOR1 Gene

  1. Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. (PMID: 15528197) Mizuhara E. … Ono Y. (J. Biol. Chem. 2005) 2 23 67
  2. Fussel-15, a new player in wound healing, is deregulated in keloid and localized scleroderma. (PMID: 21641385) Arndt S. … Bosserhoff A.K. (Am. J. Pathol. 2011) 67
  3. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. (PMID: 21779176) Winkelmann J. … Meitinger T. (PLoS Genet. 2011) 67
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes E.K. … Loos R.J. (Nat. Genet. 2010) 67
  5. Association of intronic variants of the BTBD9 gene with Tourette syndrome. (PMID: 19822783) RiviA"re J.B. … Rouleau G.A. (Arch. Neurol. 2009) 67

Products for SKOR1 Gene

Sources for SKOR1 Gene

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