SKOR1 Gene
protein-coding GIFtS: 44
GCID: GC15P068113
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SKI family transcriptional corepressor 1(Previous name: Lbxcor1 homolog (mouse) )
(Previous symbol: LBXCOR1)
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Aliases
for SKOR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SKI Family Transcriptional Corepressor 11 2 | | Lbxcor1 Homolog (Mouse)1 | | CORL11 2 3 5 | | Corepressor For LBX12 | | LBXCOR11 2 3 5 | | Functional Smad Suppressing Element 152 | | FUSSEL151 2 3 | | Fussel-153 | | Functional Smad-Suppressing Element On Chromosome 152 3 | | Lbxcor1 Homolog2 | | Ladybird Homeobox Corepressor 12 3 | | Transcriptional Corepressor CORL12 | | LBX1 Corepressor 12 3 | | Fussel-153 |
Export aliases for SKOR1 gene to outside databasesPrevious GC identifer: GC15P044951 |
Summaries
for SKOR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SKOR1_HUMAN, P84550Function: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling
|
Genomic Views
for SKOR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SKOR1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SKOR1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKOR1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q23SKOR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P068113: view genomic region
(about GC identifiers)
Start:
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68,112,042 bp from pter |
End:
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68,126,899 bp from pter |
Size:
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14,858 bases |
Orientation:
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plus strand |
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Proteins
for SKOR1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SKOR1_HUMAN, P84550 (See
protein sequence)Recommended Name: SKI family transcriptional corepressor 1 Size: 965 amino acids; 99831 Da
Subunit: Interacts with LBX1 (By similarity). Interacts with SMAD1, SMAD2 and SMAD3
Subcellular location: Nucleus (By similarity)
Secondary accessions: A6NIP4 A6NJY0 Q2VWA5Alternative splicing: 3 isoforms: P84550-1 P84550-2 P84550-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SKOR1: NX_P84550
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P84550
SKOR1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001244953.1
ENSEMBL proteins: ENSP00000343200 ENSP00000451193 ENSP00000452361 ENSP00000369374 ENSP00000373654
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SKOR1 for ontologies About GeneDecksing
SKOR1 Antibody Products:
Assay Products for SKOR1: |
Protein
Domains /
Families
for SKOR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SKOR1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P84550ProtoNet protein and cluster: P84550 2 Blocks protein families: IPB000770 SAND domain IPB010919 SAND-like
UniProtKB/Swiss-Prot: SKOR1_HUMAN, P84550Similarity: Belongs to the SKI family |
Function
for SKOR1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SKOR1_HUMAN, P84550Function: Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKOR1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SKOR1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SKOR1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SKOR1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for SKOR1 (P845503 ENSP000003736544) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IBA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
NAS | 17292623 | | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
IBA | -- | | GO:0030514 | negative regulation of BMP signaling pathway |
IDA | 17292623 |
SKOR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SKOR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SKOR1
Search CenterWatch for drugs/clinical trials and news about SKOR1
|
Transcripts
for SKOR1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SKOR1 gene (2 alternative transcripts): NM_001031807.1 NM_001258024.1 Unigene Cluster for SKOR1: SKI family transcriptional corepressor 1 Hs.451224 [show with all ESTs]Unigene Representative Sequence: AY6695075 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341418 ENST00000554240 ENST00000554054 ENST00000380035 ENST00000389002(uc002aqy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SKOR1 (NM_001031807) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SKOR1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKOR1 |
Additional cDNA sequence: AY669507.1 1 DOTS entry: DT.101970423 2 AceView cDNA sequences: CF136193 BI831656
GeneLoc Exon Structure
|
Expression
for SKOR1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SKOR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGGCCAG
About this image
See SKOR1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.451224
UniProtKB/Swiss-Prot: SKOR1_HUMAN, P84550Tissue specificity: Present specifically in cerebellar Purkinje cells (at protein level)
SABiosciences Custom PCR Arrays for SKOR1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKOR1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SKOR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKOR1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKOR1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKOR1 |
Orthologs
for SKOR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SKOR1 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SKOR16 |
Uncharacterized protein |
65(a) |
1 ↔ 1 |
10(21230383-21234994) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.131542 |
Transcribed sequences |
81.34(n) |
|
BX726161.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
skor1a6skor1b6 |
SKI family transcriptional corepressor 1b |
59(a)55(a) |
many → 1many → 1 |
7(35289896-35296061) 18(19755322-19762740) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG110936 |
-- |
27(a) |
1 → many |
4(982967-999048) |
Species with no ortholog for SKOR1
ENSEMBL Gene Tree for SKOR1 (if available)
TreeFam Gene Tree for SKOR1 (if available) |
Paralogs
for SKOR1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SKOR1 gene
- SKI2 SKOR22 SKIL2
1 SIMAP similar gene for SKOR1 using alignment to 3 protein entries: SKOR1_HUMAN (see all proteins):SKI
SKOR1 for paralogs About GeneDecksing
|
Genomic Variants
for SKOR1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SKOR1 (68112042 - 68126899 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SKOR1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SKOR1 |
|
Disorders
/ Diseases
for SKOR1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SKOR1 for disorders About GeneDecksing
OMIM gene information: 611273
OMIM disorders: --
6  diseases for SKOR1: About MalaCardsrestless legs syndrome localized scleroderma tourette syndrome scleroderma
keloids neuronitis
Human Genome Epidemiology (HuGE) Navigator: SKOR1 (0 documents)
Export disorders for SKOR1 gene to outside databases
|
Publications
for SKOR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SKOR1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SKOR1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. (PubMed id 15528197)1, 3, 9 Mizuhara E....Ono Y. (2005)
- Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling. (PubMed id 17292623)1, 2 Arndt S.... Bosserhoff A.-K. (2007)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
- Fussel-15, a new player in wound healing, is deregula ted in keloid and localized scleroderma. (PubMed id 21641385)1 Arndt S....Bosserhoff A.K. (2011)
- Genome-wide association study identifies novel restles s legs syndrome susceptibility loci on 2p14 and 16q12.1. (PubMed id 21779176)1 Winkelmann J....Meitinger T. (2011)
- Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
- Association of intronic variants of the BTBD9 gene wi th Tourette syndrome. (PubMed id 19822783)1 RiviA"re J.B....Rouleau G.A. (2009)
- Replication of restless legs syndrome loci in three European populations. (PubMed id 19279021)1 Kemlink D....Winkelmann J. (2009)
- Genetics of restless legs syndrome. (PubMed id 18541116)1 Winkelmann J. (2008)
- Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. (PubMed id 17637780)1 Winkelmann J....Meitinger T. (2007)
|
External Searches for SKOR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SKOR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SKOR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SKOR1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SKOR1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SKOR1 gene:
Search GeneIP for patents involving SKOR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SKOR1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SKOR1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SKOR1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKOR1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SKOR1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKOR1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SKOR1 | | OriGene Custom Protein Services for SKOR1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SKOR1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SKOR1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKOR1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SKOR1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKOR1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKOR1 |
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 | | | SKOR1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKOR1 |
|  |  |  | | | | Search ThermoFisher Antibodies for SKOR1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKOR1 |
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