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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SKIV2L2 Gene

protein-coding   GIFtS: 57
GCID: GC05P054605

Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae)

(Previous name: KIAA0052)
(Previous symbol: KIAA0052)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae)1 2     Dob12
KIAA00521 2 3     fSAP1182
Functional Spliceosome-Associated Protein 1181 2     Superkiller Viralicidic Activity 2-Like 22
Mtr42 3     EC 3.6.4.133
ATP-Dependent Helicase SKIV2L22 3     EC 3.6.18

External Ids:    HGNC: 187341   Entrez Gene: 235172   Ensembl: ENSG000000391237   UniProtKB: P422853   

Export aliases for SKIV2L2 gene to outside databases

Previous GC identifers: GC05P054640 GC05P051576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SKIV2L2 Gene: 
SKIV2L2 (superkiller viralicidic activity 2-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with SKIV2L2 include tuberculosis, and rheumatoid arthritis, and among its related super-pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DDX60.

UniProtKB/Swiss-Prot: SK2L2_HUMAN, P42285
Function: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the
3'processing of the 7S pre-RNA to the mature 5.8S rRNA

Gene Wiki entry for SKIV2L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SKIV2L2 gene promoter:
         TBP   CUTL1   RORalpha2   C/EBPalpha   CHOP-10   E2F-1   E2F   Sox9   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKIV2L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SKIV2L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKIV2L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

SKIV2L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKIV2L2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P054605:  view genomic region     (about GC identifiers)

Start:
54,603,576 bp from pter      End:
54,721,409 bp from pter
Size:
117,834 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SK2L2_HUMAN, P42285 (See protein sequence)
Recommended Name: Superkiller viralicidic activity 2-like 2  
Size: 1042 amino acids; 117805 Da
Subunit: Associated with the RNA exosome complex. Identified in the spliceosome C complex
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAH65258.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA06124.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q2M386 Q6MZZ8 Q6P170 Q8N5R0 Q8TAG2

Explore the universe of human proteins at neXtProt for SKIV2L2: NX_P42285

Explore proteomics data for SKIV2L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P42285

  • 4/6 DME Specific Peptides for SKIV2L2 (P42285) (see all 6)
     NNQSVLV  LFATETF  KGRVACEI  QMSGRAGR 

    SKIV2L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SKIV2L2 Protein Expression
    REFSEQ proteins: NP_056175.3  
    ENSEMBL proteins: 
     ENSP00000230640   ENSP00000425042   ENSP00000422125   ENSP00000426641   ENSP00000442583  

    Human Recombinant Protein Products for SKIV2L2: 
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    Cloud-Clone Corp. Proteins for SKIV2L2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000178colocalizes with exosome (RNase complex) IDA11719186
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IEA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    SKIV2L2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR012961 DSH_C
     IPR027417 P-loop_NTPase
     IPR025696 rRNA_proc-arch_dom
     IPR016438 RNA_helicase_ATP-dep_SK12/DOB1

    Graphical View of Domain Structure for InterPro Entry P42285

    ProtoNet protein and cluster: P42285

    1 Blocks protein domain: IPB012961 DSH

    UniProtKB/Swiss-Prot: SK2L2_HUMAN, P42285
    Similarity: Belongs to the helicase family. SKI2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    SKIV2L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SK2L2_HUMAN, P42285
    Function: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the
    3'processing of the 7S pre-RNA to the mature 5.8S rRNA
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI15231747
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    SKIV2L2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SKIV2L2:
     Decreased viability  Decreased viability of wild-ty  Increased circadian rhythm amp  Nuclear pre-40S maturation def 

         1 MGI phenotypic allele for Skiv2l2 (no phenotypes)

    SKIV2L2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SKIV2L2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKIV2L2 
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SKIV2L2 (see all 9):
    hsa-miR-411* hsa-miR-379* hsa-miR-1224-3p hsa-miR-432 hsa-miR-567 hsa-miR-320e hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSKIV2L2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SKIV2L2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for SKIV2L2):
        RNA degradation


    SKIV2L2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SKIV2L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/665 Interacting proteins for SKIV2L2 (P422851, 2, 3 ENSP000002306404) via UniProtKB, MINT, STRING, and/or I2D (see all 665)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7947479 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7947479 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7947479 I2D: score=1 
    ENSG00000229496Q138382, 3MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0000460maturation of 5.8S rRNA IMP17412707

    SKIV2L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SKIV2L2 (SK2L2)

    Search CenterWatch for drugs/clinical trials and news about SKIV2L2 / SK2L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SKIV2L2 gene: 
    NM_015360.4  

    Unigene Cluster for SKIV2L2:

    Superkiller viralicidic activity 2-like 2 (S. cerevisiae)
    Hs.274531  [show with all ESTs]
    Unigene Representative Sequence: NM_015360
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230640(uc003jpy.4 uc011cqi.2) ENST00000504388 ENST00000506750
    ENST00000503165 ENST00000504997 ENST00000505565 ENST00000502953 ENST00000518955
    ENST00000508716 ENST00000545714
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SKIV2L2 (see all 9):
    hsa-miR-411* hsa-miR-379* hsa-miR-1224-3p hsa-miR-432 hsa-miR-567 hsa-miR-320e hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSKIV2L2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF085966.1 AK123505.1 AK291649.1 AK304788.1 BC014669.2 BC028604.2 BC031779.1 BC065258.1 
    BC104996.1 BC105291.1 BC113509.1 BX640789.1 D29641.2 

    22 DOTS entries:

    DT.97856812  DT.101966979  DT.92446699  DT.100656484  DT.101974792  DT.120816792  DT.100656488  DT.219660 
    DT.92446687  DT.100802921  DT.95070515  DT.95083975  DT.100892051  DT.86856159  DT.92446681  DT.92446683 
    DT.92446684  DT.95148960  DT.95175811  DT.120816921  DT.91900480  DT.95148998 

    24/221 AceView cDNA sequences (see all 221):

    AW168117 BF725650 AW770148 BI259169 CB322042 AI379890 BM460627 AI613226 
    AI687386 AI422598 BM129813 CB138419 AA211854 W07035 BQ129304 BM555897 
    AI275980 AW023824 CB851633 F13234 BF970210 AA815042 AI056824 AI289487 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SKIV2L2 expression in normal human tissues (normalized intensities)      SKIV2L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SKIV2L2 Expression
    About this image


    SKIV2L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             trachea   
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See SKIV2L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SKIV2L2

    SOURCE GeneReport for Unigene cluster: Hs.274531
        SABiosciences Custom PCR Arrays for SKIV2L2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SKIV2L2 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skiv2l21 , 5 superkiller viralicidic activity 2-like 2 (S. cerevisiae)1, 5 88.46(n)1
    97.69(a)1
      13 (63.93 cM)5
    721981  NM_028151.21  NP_082427.11 
     1128677805 
    chicken
    (Gallus gallus)
    Aves SKIV2L21 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 81.6(n)
    92.13(a)
      427137  NM_001012944.1  NP_001012962.1 
    lizard
    (Anolis carolinensis)
    Reptilia SKIV2L26
    superkiller viralicidic activity 2-like 2 (S. cere...
    88(a)
    1 ↔ 1
    2(2528609-2573163)
    zebrafish
    (Danio rerio)
    Actinopterygii skiv2l21 superkiller viralicidic activity 2-like 2 73.81(n)
    86.76(a)
      406795  NM_214768.1  NP_999933.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)35Df1 lethal (2) 35Df 59.84(n)
    64.61(a)
      48782  NM_080190.2  NP_524929.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mtr-41 Protein MTR-4 56.68(n)
    52.61(a)
      177824  NM_069356.4  NP_501757.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTR4(YJL050W)4
    MTR41
    ATP-dependent 3'-5' RNA helicase of the Dead-box family, more4
    Mtr4p1
    57.41(n)1
    53.19(a)1
      10(342522-345743)4
    8533971, 4  NP_012485.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G597601 RNA helicase 58.24(n)
    56.8(a)
      842269  NM_104669.3  NP_176185.1 


    ENSEMBL Gene Tree for SKIV2L2 (if available)
    TreeFam Gene Tree for SKIV2L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SKIV2L2 gene
    DDX602  DDX60L2  
    2 SIMAP similar genes for SKIV2L2 using alignment to 7 protein entries:     SK2L2_HUMAN (see all proteins):
    SKIV2L    SKI2W

    SKIV2L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2190 SNPs in SKIV2L2 are shown (see all 2190)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891826441,2
    --54605565(+) GGTATA/GTATTT 1 -- int10--------
    rs1913840291,2
    --54605651(+) AGAGGG/TTACAT 1 -- int10--------
    rs1380134551,2
    --54605695(+) AATTCC/TATCAG 1 -- int10--------
    rs1839570701,2
    --54605920(+) TTTACC/TTCAAA 1 -- int10--------
    rs1868129701,2
    C--54606158(+) TCCTGA/G/TCCGGG 1 -- int10--------
    rs104719411,2
    C,F,A,H--54606227(+) GGTCAA/GGAGTT 1 -- int15Minor allele frequency- G:0.10NA WA CSA 127
    rs1431726481,2
    --54606691(+) ACCTCA/GAACTC 1 -- int10--------
    rs1482808101,2
    --54606930(+) AAAAAA/GCTTTA 1 -- int10--------
    rs773763701,2
    F--54607192(+) TGATCA/GTTGGT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1152457641,2
    C,F--54607231(+) ACACTG/ATTTTT 1 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for SKIV2L2 (54603576 - 54721409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SKIV2L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660955CNV Deletion23128226
    nsv435812CNV Deletion17901297
    nsv880340CNV Loss21882294
    dgv6070n71CNV Loss21882294
    dgv6072n71CNV Loss21882294
    nsv518688CNV Loss19592680
    nsv523841CNV Loss19592680
    dgv6071n71CNV Loss21882294
    nsv823079CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for SKIV2L2:    About MalaCards
    tuberculosis    rheumatoid arthritis    arthritis


    SKIV2L2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SKIV2L2
    Human Genome Epidemiology (HuGE) Navigator: SKIV2L2 (1 document)

    Export disorders for SKIV2L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SKIV2L2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with SKIV2L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PubMed id 18309376)1, 4 Lee H.S....Gregersen P.K. (2008)
    2. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PubMed id 17412707)1, 2 Schilders G.... Pruijn G.J.M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    6. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (2001)
    7. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23517 HGNC: 18734 AceView: KIAA0052 Ensembl:ENSG00000039123 euGenes: HUgn23517
    ECgene: SKIV2L2 Kegg: 23517 H-InvDB: SKIV2L2

    (According to HUGE)
    About This Section
    HUGE: KIAA0052

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SKIV2L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SKIV2L2 gene:
    Search GeneIP for patents involving SKIV2L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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