Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SKIV2L2 Gene

Aliases for SKIV2L2 Gene

  • Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae) 2 3
  • KIAA0052 2 3 4
  • Functional Spliceosome-Associated Protein 118 2 3
  • ATP-Dependent RNA Helicase SKIV2L2 3 4
  • TRAMP-Like Complex Helicase 3 4
  • Mtr4 3 4
  • Superkiller Viralicidic Activity 2-Like 2 3
  • ATP-Dependent Helicase SKIV2L2 3
  • EC 3.6.4.13 4
  • EC 3.6.1 64
  • FSAP118 3
  • Dob1 3

External Ids for SKIV2L2 Gene

Previous Symbols for SKIV2L2 Gene

  • KIAA0052

Summaries for SKIV2L2 Gene

GeneCards Summary for SKIV2L2 Gene

SKIV2L2 (Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DDX60.

UniProtKB/Swiss-Prot for SKIV2L2 Gene

  • May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3-processing of the 7S pre-RNA to the mature 5.8S rRNA.

Gene Wiki entry for SKIV2L2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKIV2L2 Gene

Genomics for SKIV2L2 Gene

Genomic Location for SKIV2L2 Gene

Start:
55,307,748 bp from pter
End:
55,425,581 bp from pter
Size:
117,834 bases
Orientation:
Plus strand

Genomic View for SKIV2L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKIV2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIV2L2 Gene

Regulatory Elements for SKIV2L2 Gene

Proteins for SKIV2L2 Gene

  • Protein details for SKIV2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42285-SK2L2_HUMAN
    Recommended name:
    Superkiller viralicidic activity 2-like 2
    Protein Accession:
    P42285
    Secondary Accessions:
    • Q2M386
    • Q6MZZ8
    • Q6P170
    • Q8N5R0
    • Q8TAG2

    Protein attributes for SKIV2L2 Gene

    Size:
    1042 amino acids
    Molecular mass:
    117805 Da
    Quaternary structure:
    • Component of a TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Identified in the spliceosome C complex.
    SequenceCaution:
    • Sequence=AAH65258.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA06124.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SKIV2L2 Gene

Proteomics data for SKIV2L2 Gene at MOPED

Selected DME Specific Peptides for SKIV2L2 Gene

Post-translational modifications for SKIV2L2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys192, Lys587, Lys852, Lys873, and Lys1022

Other Protein References for SKIV2L2 Gene

Domains for SKIV2L2 Gene

UniProtKB/Swiss-Prot:

SK2L2_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • P42285
  • Contains 1 helicase C-terminal domain.:
    • P42285
Family:
  • Belongs to the helicase family. SKI2 subfamily.:
    • P42285
genes like me logo Genes that share domains with SKIV2L2: view

No data available for Gene Families for SKIV2L2 Gene

Function for SKIV2L2 Gene

Molecular function for SKIV2L2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3-processing of the 7S pre-RNA to the mature 5.8S rRNA.

Enzyme Numbers (IUBMB) for SKIV2L2 Gene

Gene Ontology (GO) - Molecular Function for SKIV2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 15231747
GO:0005524 ATP binding IEA --
GO:0016817 hydrolase activity, acting on acid anhydrides --
genes like me logo Genes that share ontologies with SKIV2L2: view
genes like me logo Genes that share phenotypes with SKIV2L2: view

miRNA for SKIV2L2 Gene

miRTarBase miRNAs that target SKIV2L2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SKIV2L2 Gene

Localization for SKIV2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKIV2L2 Gene

Nucleus, nucleoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKIV2L2 Gene COMPARTMENTS Subcellular localization image for SKIV2L2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SKIV2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000178 colocalizes_with exosome (RNase complex) IDA 11719186
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SKIV2L2: view

Pathways for SKIV2L2 Gene

SuperPathways for SKIV2L2 Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with SKIV2L2: view

Pathways by source for SKIV2L2 Gene

1 KEGG pathway for SKIV2L2 Gene

Gene Ontology (GO) - Biological Process for SKIV2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0000460 maturation of 5.8S rRNA IMP 17412707
genes like me logo Genes that share ontologies with SKIV2L2: view

Transcripts for SKIV2L2 Gene

Unigene Clusters for SKIV2L2 Gene

Superkiller viralicidic activity 2-like 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKIV2L2 Gene

No ASD Table

Relevant External Links for SKIV2L2 Gene

GeneLoc Exon Structure for
SKIV2L2
ECgene alternative splicing isoforms for
SKIV2L2

Expression for SKIV2L2 Gene

mRNA expression in normal human tissues for SKIV2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKIV2L2 Gene

SOURCE GeneReport for Unigene cluster for SKIV2L2 Gene Hs.274531

genes like me logo Genes that share expressions with SKIV2L2: view

Orthologs for SKIV2L2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SKIV2L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKIV2L2 36
  • 99.84 (n)
  • 99.81 (a)
SKIV2L2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKIV2L2 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKIV2L2 36
  • 94.15 (n)
  • 98.85 (a)
SKIV2L2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skiv2l2 36
  • 88.37 (n)
  • 97.5 (a)
Skiv2l2 16
Skiv2l2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKIV2L2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKIV2L2 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Skiv2l2 36
  • 89.83 (n)
  • 97.79 (a)
chicken
(Gallus gallus)
Aves SKIV2L2 36
  • 81.6 (n)
  • 92.13 (a)
SKIV2L2 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKIV2L2 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia skiv2l2 36
  • 77.22 (n)
  • 89.42 (a)
zebrafish
(Danio rerio)
Actinopterygii skiv2l2 36
  • 73.3 (n)
  • 86.54 (a)
skiv2l2 37
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009600 36
  • 58.23 (n)
  • 64.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Df 36
  • 61.03 (n)
  • 66.77 (a)
l(2)35Df 37
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mtr-4 36
  • 57.12 (n)
  • 53.17 (a)
mtr-4 37
  • 50 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL181C 36
  • 56.57 (n)
  • 55.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR4 36
  • 59.64 (n)
  • 56.99 (a)
MTR4 37
  • 50 (a)
OneToMany
MTR4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01364g 36
  • 58.61 (n)
  • 57.14 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G59760 36
  • 58.67 (n)
  • 57.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03363 36
  • 53.41 (n)
  • 53.51 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mtr4 36
  • 60.88 (n)
  • 60.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8524 37
  • 60 (a)
OneToOne
Species with no ortholog for SKIV2L2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SKIV2L2 Gene

ENSEMBL:
Gene Tree for SKIV2L2 (if available)
TreeFam:
Gene Tree for SKIV2L2 (if available)

Paralogs for SKIV2L2 Gene

Paralogs for SKIV2L2 Gene

Selected SIMAP similar genes for SKIV2L2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SKIV2L2: view

Variants for SKIV2L2 Gene

Sequence variations from dbSNP and Humsavar for SKIV2L2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs170738 -- 55,421,097(-) CCGAA(A/G)CAAAA intron-variant
rs230753 -- 55,422,790(-) ACACA(C/G)GATAA intron-variant
rs230754 -- 55,422,587(-) TGCAA(A/G)GATGA intron-variant
rs230755 -- 55,422,194(-) CTTGT(C/G)CAAAG intron-variant
rs230756 -- 55,421,722(-) CTGCA(C/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKIV2L2 Gene

Variant ID Type Subtype PubMed ID
dgv6070n71 CNV Loss 21882294
dgv6071n71 CNV Loss 21882294
esv2660955 CNV Deletion 23128226
nsv880340 CNV Loss 21882294
dgv6072n71 CNV Loss 21882294
nsv523841 CNV Loss 19592680
nsv518688 CNV Loss 19592680
nsv823079 CNV Loss 20364138
nsv435812 CNV Deletion 17901297

Relevant External Links for SKIV2L2 Gene

HapMap Linkage Disequilibrium report
SKIV2L2

Disorders for SKIV2L2 Gene

Relevant External Links for SKIV2L2

Genetic Association Database (GAD)
SKIV2L2
Human Genome Epidemiology (HuGE) Navigator
SKIV2L2
genes like me logo Genes that share disorders with SKIV2L2: view

No data available for UniProtKB/Swiss-Prot for SKIV2L2 Gene

Publications for SKIV2L2 Gene

  1. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PMID: 18309376) Lee H.S. … Gregersen P.K. (Mol. Med. 2008) 3 49
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  3. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PMID: 11719186) Chen C.-Y. … Karin M. (Cell 2001) 3 4
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4

Products for SKIV2L2 Gene

  • antibodies-online peptides for SKIV2L2
  • antibodies-online antibodies for SKIV2L2
  • antibodies-online kits for SKIV2L2

Sources for SKIV2L2 Gene

Back to Top

Content