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SKIV2L2 Gene

protein-coding   GIFtS: 58
GCID: GC05P054605

Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae)

(Previous name: KIAA0052)
(Previous symbol: KIAA0052)
  Search for SKIV2L2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Superkiller Viralicidic Activity 2-Like 2 (S. Cerevisiae)1 2     Dob12
KIAA00521 2 3     ATP-Dependent Helicase SKIV2L22
Functional Spliceosome-Associated Protein 1181 2     fSAP1182
Mtr42 3     Superkiller Viralicidic Activity 2-Like 22
ATP-Dependent RNA Helicase SKIV2L22 3     EC 3.6.4.133
TRAMP-Like Complex Helicase2 3     EC 3.6.18

External Ids:    HGNC: 187341   Entrez Gene: 235172   Ensembl: ENSG000000391237   UniProtKB: P422853   

Export aliases for SKIV2L2 gene to outside databases

Previous GC identifers: GC05P054640 GC05P051576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SKIV2L2 Gene:
SKIV2L2 (superkiller viralicidic activity 2-like 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DDX60.

UniProtKB/Swiss-Prot: SK2L2_HUMAN, P42285
Function: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the
3'-processing of the 7S pre-RNA to the mature 5.8S rRNA

Gene Wiki entry for SKIV2L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the SKIV2L2 gene promoter:
         TBP   CUTL1   RORalpha2   C/EBPalpha   CHOP-10   E2F-1   E2F   Sox9   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKIV2L2 promoter sequence
   Search Chromatin IP Primers for SKIV2L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKIV2L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

SKIV2L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKIV2L2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P054605:  view genomic region     (about GC identifiers)

Start:
54,603,576 bp from pter      End:
54,721,409 bp from pter
Size:
117,834 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SK2L2_HUMAN, P42285 (See protein sequence)
Recommended Name: Superkiller viralicidic activity 2-like 2  
Size: 1042 amino acids; 117805 Da
Subunit: Component of a TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase
(SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7
or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or
nucleolar RNA exosomes. Identified in the spliceosome C complex
Sequence caution: Sequence=AAH65258.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA06124.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q2M386 Q6MZZ8 Q6P170 Q8N5R0 Q8TAG2

Explore the universe of human proteins at neXtProt for SKIV2L2: NX_P42285

Explore proteomics data for SKIV2L2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys192, Lys587, Lys852, Lys873, Lys1022
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for SKIV2L2 (P42285) (see all 6)
     NNQSVLV  LFATETF  KGRVACEI  QMSGRAGR 


    See SKIV2L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056175.3  
    ENSEMBL proteins: 
     ENSP00000230640   ENSP00000425042   ENSP00000422125   ENSP00000426641   ENSP00000442583  

    SKIV2L2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR025696 rRNA_proc-arch_dom
     IPR016438 RNA_helicase_ATP-dep_SK12/DOB1
     IPR012961 DSH_C
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P42285

    ProtoNet protein and cluster: P42285

    1 Blocks protein domain: IPB012961 DSH

    UniProtKB/Swiss-Prot: SK2L2_HUMAN, P42285
    Similarity: Belongs to the helicase family. SKI2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with SKIV2L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SK2L2_HUMAN, P42285
    Function: May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the
    3'-processing of the 7S pre-RNA to the mature 5.8S rRNA
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI15231747
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    Find genes that share ontologies with SKIV2L2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SKIV2L2:
     Decreased viability  Decreased viability of wild-ty  Increased circadian rhythm amp  Nuclear pre-40S maturation def 

         1 MGI phenotypic allele for Skiv2l2 (no phenotypes)

    Find genes that share phenotypes with SKIV2L2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKIV2L2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKIV2L2
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    miRNA
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    miRTarBase miRNAs that target SKIV2L2:
    hsa-mir-155-5p (MIRT020972), hsa-mir-26b-5p (MIRT030044)

    Block miRNA regulation of human, mouse, rat SKIV2L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SKIV2L2 (see all 9):
    hsa-miR-411* hsa-miR-379* hsa-miR-1224-3p hsa-miR-432 hsa-miR-567 hsa-miR-320e hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSKIV2L2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SKIV2L2

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKIV2L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SK2L2_HUMAN, P42285: Nucleus, nucleoplasm. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000178colocalizes with exosome (RNase complex) IDA11719186
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    Find genes that share ontologies with SKIV2L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKIV2L2 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48


    Find genes that share SuperPaths with SKIV2L2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SKIV2L2):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SKIV2L2
    Interactions:

        Search GeneGlobe Interaction Network for SKIV2L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SKIV2L2 (P422851, 2, 3 ENSP000002306404) via UniProtKB, MINT, STRING, and/or I2D (see all 713)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-7947479 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7947479 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7947479 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7947479 I2D: score=1 
    ENSG00000229496Q138382, 3MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0000460maturation of 5.8S rRNA IMP17412707

    Find genes that share ontologies with SKIV2L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SKIV2L2 (SK2L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SKIV2L2 gene: 
    NM_015360.4  

    Unigene Cluster for SKIV2L2:

    Superkiller viralicidic activity 2-like 2 (S. cerevisiae)
    Hs.274531  [show with all ESTs]
    Unigene Representative Sequence: NM_015360
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230640(uc003jpy.4 uc011cqi.2) ENST00000504388 ENST00000506750
    ENST00000503165 ENST00000504997 ENST00000505565 ENST00000502953 ENST00000518955
    ENST00000508716 ENST00000545714
    miRNA
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    Block miRNA regulation of human, mouse, rat SKIV2L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SKIV2L2 (see all 9):
    hsa-miR-411* hsa-miR-379* hsa-miR-1224-3p hsa-miR-432 hsa-miR-567 hsa-miR-320e hsa-miR-155 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidSKIV2L2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SKIV2L2
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      QuantiTect SYBR Green Assays in human, mouse, rat SKIV2L2
      QuantiFast Probe-based Assays in human, mouse, rat SKIV2L2

    Additional mRNA sequence: 

    AF085966.1 AK123505.1 AK291649.1 AK304788.1 BC014669.2 BC028604.2 BC031779.1 BC065258.1 
    BC104996.1 BC105291.1 BC113509.1 BX640789.1 D29641.2 

    22 DOTS entries:

    DT.97856812  DT.101966979  DT.92446699  DT.100656484  DT.101974792  DT.120816792  DT.100656488  DT.219660 
    DT.92446687  DT.100802921  DT.95070515  DT.95083975  DT.100892051  DT.86856159  DT.92446681  DT.92446683 
    DT.92446684  DT.95148960  DT.95175811  DT.120816921  DT.91900480  DT.95148998 

    Selected AceView cDNA sequences (see all 221):

    BG392145 AI333080 BM476565 CB044754 BC065258 F10835 BC014669 D29641 
    N77949 BU160722 AA450207 AF085966 BQ002194 AA489487 CA445886 AK123505 
    BM463765 BC031779 BM699031 BP337491 AA815042 AI056824 AI289487 AL522435 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SKIV2L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SKIV2L2 Expression
    About this image


    SKIV2L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    SKIV2L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKIV2L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274531
        Custom PCR Arrays for SKIV2L2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKIV2L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SKIV2L2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skiv2l21 , 5 superkiller viralicidic activity 2-like 2 (S. cerevisiae)1, 5 88.37(n)1
    97.5(a)1
      13 (63.93 cM)5
    721981  NM_028151.21  NP_082427.11 
     1128677805 
    chicken
    (Gallus gallus)
    Aves SKIV2L21 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 81.6(n)
    92.13(a)
      427137  NM_001012944.1  NP_001012962.1 
    lizard
    (Anolis carolinensis)
    Reptilia SKIV2L26
    superkiller viralicidic activity 2-like 2 (S. cere...
    87(a)
    1 ↔ 1
    2(2528609-2573163)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia skiv2l21 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 77.22(n)
    89.42(a)
      100496866  XM_002941111.2  XP_002941157.1 
    zebrafish
    (Danio rerio)
    Actinopterygii skiv2l21 superkiller viralicidic activity 2-like 2 73.3(n)
    86.54(a)
      406795  NM_214768.1  NP_999933.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)35Df1 lethal (2) 35Df 61.03(n)
    66.77(a)
      48782  NM_080190.2  NP_524929.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mtr-41 mtr-4 57.12(n)
    53.17(a)
      177824  NM_069356.5  NP_501757.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTR4(YJL050W)4
    MTR41
    ATP-dependent 3'-5' RNA helicase of the Dead-box family, more4
    MTR41
    59.64(n)1
    56.99(a)1
      10(342522-345743)4
    8533971, 4  NP_012485.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G597601 AT1G59760 58.67(n)
    57.16(a)
      842269  NM_104669.3  NP_176185.1 


    ENSEMBL Gene Tree for SKIV2L2 (if available)
    TreeFam Gene Tree for SKIV2L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SKIV2L2 gene
    DDX602  DDX60L2  
    2 SIMAP similar genes for SKIV2L2 using alignment to 7 protein entries:     SK2L2_HUMAN (see all proteins):
    SKIV2L    SKI2W

    Find genes that share paralogs with SKIV2L2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SKIV2L2 (see all 2190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891826441,2
    --54605565(+) GGTATA/GTATTT 1 -- int10--------
    rs1913840291,2
    --54605651(+) AGAGGG/TTACAT 1 -- int10--------
    rs1380134551,2
    --54605695(+) AATTCC/TATCAG 1 -- int10--------
    rs1839570701,2
    --54605920(+) TTTACC/TTCAAA 1 -- int10--------
    rs1868129701,2
    C--54606158(+) TCCTGA/G/TCCGGG 1 -- int10--------
    rs104719411,2
    C,F,A,H--54606227(+) GGTCAA/GGAGTT 1 -- int15Minor allele frequency- G:0.10NA WA CSA 127
    rs1431726481,2
    --54606691(+) ACCTCA/GAACTC 1 -- int10--------
    rs1482808101,2
    --54606930(+) AAAAAA/GCTTTA 1 -- int10--------
    rs773763701,2
    F--54607192(+) TGATCA/GTTGGT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1152457641,2
    C,F--54607231(+) ACACTG/ATTTTT 1 -- int11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for SKIV2L2 (54603576 - 54721409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SKIV2L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660955CNV Deletion23128226
    nsv435812CNV Deletion17901297
    nsv880340CNV Loss21882294
    dgv6070n71CNV Loss21882294
    dgv6072n71CNV Loss21882294
    nsv518688CNV Loss19592680
    nsv523841CNV Loss19592680
    dgv6071n71CNV Loss21882294
    nsv823079CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SKIV2L2
    DNA2.0 Custom Variant and Variant Library Synthesis for SKIV2L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SKIV2L2           About GenesLikeMe

    Genetic Association Database (GAD): SKIV2L2
    Human Genome Epidemiology (HuGE) Navigator: SKIV2L2 (1 document)

    Export disorders for SKIV2L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SKIV2L2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SKIV2L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PubMed id 18309376)1, 4 Lee H.S....Gregersen P.K. (Mol. Med. 2008)
    2. C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing. (PubMed id 17412707)1, 2 Schilders G.... Pruijn G.J.M. (Nucleic Acids Res. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. (PubMed id 11719186)1, 2 Chen C.-Y.... Karin M. (Cell 2001)
    7. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23517 HGNC: 18734 AceView: KIAA0052 Ensembl:ENSG00000039123 euGenes: HUgn23517
    ECgene: SKIV2L2 Kegg: 23517 H-InvDB: SKIV2L2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0052

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SKIV2L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SKIV2L2 gene:
    Search GeneIP for patents involving SKIV2L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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