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Aliases for SKIL Gene

Aliases for SKIL Gene

  • SKI-Like Proto-Oncogene 2 3
  • SNO 3 4 6
  • SKI-Like Oncogene 2 3
  • Ski-Related Oncogene SnoN 3
  • Ski-Related Oncogene 4
  • Ski-Related Protein 4
  • Ski-Like Protein 3
  • SnoA 3
  • SnoI 3
  • SnoN 3

External Ids for SKIL Gene

Previous GeneCards Identifiers for SKIL Gene

  • GC03P167219
  • GC03P171126
  • GC03P171479
  • GC03P171398
  • GC03P171396
  • GC03P171558
  • GC03P170075
  • GC03P167445

Summaries for SKIL Gene

Entrez Gene Summary for SKIL Gene

  • The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SKIL Gene

SKIL (SKI-Like Proto-Oncogene) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is SKI.

UniProtKB/Swiss-Prot for SKIL Gene

  • May have regulatory role in cell division or differentiation in response to extracellular signals

Gene Wiki entry for SKIL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKIL Gene

Genomics for SKIL Gene

Regulatory Elements for SKIL Gene

Transcription factor binding sites by QIAGEN in the SKIL gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SKIL Gene

170,357,678 bp from pter
170,396,849 bp from pter
39,172 bases
Plus strand

Genomic View for SKIL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIL Gene

Proteins for SKIL Gene

  • Protein details for SKIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ski-like protein
    Protein Accession:
    Secondary Accessions:
    • A6NGT1
    • B4DT50
    • O00464
    • P12756
    • Q07501

    Protein attributes for SKIL Gene

    684 amino acids
    Molecular mass:
    76976 Da
    Quaternary structure:
    • Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for SKIL Gene

    Alternative splice isoforms for SKIL Gene


neXtProt entry for SKIL Gene

Proteomics data for SKIL Gene at MOPED

Post-translational modifications for SKIL Gene

  • Ubiquitination at Lys249 and Lys423
  • Modification sites at PhosphoSitePlus

Other Protein References for SKIL Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SKIL (SKIL)

No data available for DME Specific Peptides for SKIL Gene

Domains for SKIL Gene

Gene Families for SKIL Gene

  • SKOR :SKI transcriptional corepressors

Suggested Antigen Peptide Sequences for SKIL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P12757
  • Belongs to the SKI family.
genes like me logo Genes that share domains with SKIL: view

Function for SKIL Gene

Molecular function for SKIL Gene

UniProtKB/Swiss-Prot Function:
May have regulatory role in cell division or differentiation in response to extracellular signals

Gene Ontology (GO) - Molecular Function for SKIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10531062
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 10531062
GO:0003677 NOT DNA binding IDA 10531062
GO:0003682 chromatin binding ISS --
GO:0003714 transcription corepressor activity IDA 10531062
genes like me logo Genes that share ontologies with SKIL: view
genes like me logo Genes that share phenotypes with SKIL: view

Animal Models for SKIL Gene

MGI Knock Outs for SKIL:

Animal Model Products

miRNA for SKIL Gene

miRTarBase miRNAs that target SKIL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SKIL Gene

Localization for SKIL Gene

Subcellular locations from

Jensen Localization Image for SKIL Gene COMPARTMENTS Subcellular localization image for SKIL gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SKIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 14712482
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 16109768
GO:0016605 PML body IDA 19383336
genes like me logo Genes that share ontologies with SKIL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SKIL Gene

Pathways for SKIL Gene

genes like me logo Genes that share pathways with SKIL: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SKIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0001825 blastocyst formation IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SKIL: view

Compounds for SKIL Gene

(2) Novoseek inferred chemical compound relationships for SKIL Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 49 2
lysine 0.732 3
genes like me logo Genes that share compounds with SKIL: view

Transcripts for SKIL Gene

Unigene Clusters for SKIL Gene

SKI-like oncogene:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SKIL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKIL Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: -
SP4: - -

Relevant External Links for SKIL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SKIL Gene

mRNA expression in normal human tissues for SKIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SKIL Gene

This gene is overexpressed in Cervix (68.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SKIL Gene

SOURCE GeneReport for Unigene cluster for SKIL Gene Hs.536655

mRNA Expression by UniProt/SwissProt for SKIL Gene

Tissue specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
genes like me logo Genes that share expressions with SKIL: view

Expression partners for SKIL Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SKIL Gene

Orthologs for SKIL Gene

This gene was present in the common ancestor of animals.

Orthologs for SKIL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SKIL 35
  • 91.26 (n)
  • 91.07 (a)
  • 91 (a)
(Canis familiaris)
Mammalia SKIL 35
  • 90.63 (n)
  • 91.65 (a)
  • 92 (a)
(Mus musculus)
Mammalia Skil 35
  • 85.48 (n)
  • 89.19 (a)
Skil 16
Skil 36
  • 89 (a)
(Pan troglodytes)
Mammalia SKIL 35
  • 99.51 (n)
  • 99.56 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Skil 35
  • 85.62 (n)
  • 89.81 (a)
(Monodelphis domestica)
Mammalia SKIL 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia SKIL 36
  • 73 (a)
(Gallus gallus)
Aves SKIL 35
  • 75.16 (n)
  • 75.85 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia SKIL 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia skil 35
  • 70.51 (n)
  • 72.48 (a)
(Danio rerio)
Actinopterygii LOC100007653 35
  • 54.7 (n)
  • 52.82 (a)
skila 36
  • 49 (a)
skilb 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7233 37
  • 46 (a)
Snoo 36
  • 16 (a)
Species with no ortholog for SKIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKIL Gene

Gene Tree for SKIL (if available)
Gene Tree for SKIL (if available)

Paralogs for SKIL Gene

Paralogs for SKIL Gene

Selected SIMAP similar genes for SKIL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SKIL: view

Variants for SKIL Gene

Sequence variations from dbSNP and Humsavar for SKIL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs15709 -- 170,392,741(-) TTCCA(A/T)CACAT utr-variant-3-prime
rs1045210 -- 170,396,290(+) TAGTA(A/C)ACATG utr-variant-3-prime
rs1047308 -- 170,359,679(-) GGGGG(A/G)TTGGG utr-variant-5-prime, intron-variant
rs1511174 -- 170,358,045(+) GGAGC(C/T)GCGGG upstream-variant-2KB, intron-variant
rs1511175 -- 170,358,218(+) TGGCG(C/G)GGGGA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKIL Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv519286 CNV Loss 19592680

Relevant External Links for SKIL Gene

HapMap Linkage Disequilibrium report

PCR Panel Products

  • Copy Number PCR Panels: for SKIL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKIL Gene

Disorders for SKIL Gene

(9) Novoseek inferred disease relationships for SKIL Gene

Disease -log(P) Hits PubMed IDs
nephropathy obstructive 66.6 3
cancer 29 15
melanoma 15.7 10
tumors 5.23 8
breast carcinoma 2.11 3

Relevant External Links for SKIL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
genes like me logo Genes that share disorders with SKIL: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SKIL Gene

Publications for SKIL Gene

  1. SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno. (PMID: 8233802) Pearson-White S. (Nucleic Acids Res. 1993) 3 4 23
  2. Proto-oncogene Sno expression, alternative isoforms and immediate early serum response. (PMID: 9207045) Pearson-White S.H. … Crittenden R. (Nucleic Acids Res. 1997) 3 4 23
  3. Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). (PMID: 15221015) Komuro A. … Miyazawa K. (Oncogene 2004) 3 4 23
  4. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. (PMID: 17591695) Levy L. … Hill C.S. (Mol. Cell. Biol. 2007) 3 4 23
  5. Isolation of human cDNA clones of ski and the ski-related gene, sno. (PMID: 2762147) Nomura N. … Ishizaki R. (Nucleic Acids Res. 1989) 2 3 4

Products for SKIL Gene

  • Addgene plasmids for SKIL

Sources for SKIL Gene

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