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Aliases for SKIL Gene

Aliases for SKIL Gene

  • SKI-Like Proto-Oncogene 2 3
  • SNO 3 4 6
  • SKI-Like Oncogene 2 3
  • Ski-Related Oncogene SnoN 3
  • Ski-Related Oncogene 4
  • Ski-Related Protein 4
  • Ski-Like Protein 3
  • SnoA 3
  • SnoI 3
  • SnoN 3

External Ids for SKIL Gene

Summaries for SKIL Gene

Entrez Gene Summary for SKIL Gene

  • The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SKIL Gene

SKIL (SKI-Like Proto-Oncogene) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is SKI.

UniProtKB/Swiss-Prot for SKIL Gene

  • May have regulatory role in cell division or differentiation in response to extracellular signals

Gene Wiki entry for SKIL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKIL Gene

Genomics for SKIL Gene

Genomic Location for SKIL Gene

Start:
170,357,678 bp from pter
End:
170,396,849 bp from pter
Size:
39,172 bases
Orientation:
Plus strand

Genomic View for SKIL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIL Gene

Regulatory Elements for SKIL Gene

Transcription factor binding sites by QIAGEN in the SKIL gene promoter:

Proteins for SKIL Gene

  • Protein details for SKIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12757-SKIL_HUMAN
    Recommended name:
    Ski-like protein
    Protein Accession:
    P12757
    Secondary Accessions:
    • A6NGT1
    • B4DT50
    • O00464
    • P12756
    • Q07501

    Protein attributes for SKIL Gene

    Size:
    684 amino acids
    Molecular mass:
    76976 Da
    Quaternary structure:
    • Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for SKIL Gene

    Alternative splice isoforms for SKIL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKIL Gene

Proteomics data for SKIL Gene at MOPED

Post-translational modifications for SKIL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys249 and Lys423

Other Protein References for SKIL Gene

No data available for DME Specific Peptides for SKIL Gene

Domains for SKIL Gene

Gene Families for SKIL Gene

HGNC:
  • SKOR :SKI transcriptional corepressors

UniProtKB/Swiss-Prot:

SKIL_HUMAN
Family:
  • Belongs to the SKI family.:
    • P12757
genes like me logo Genes that share domains with SKIL: view

Function for SKIL Gene

Molecular function for SKIL Gene

UniProtKB/Swiss-Prot Function: May have regulatory role in cell division or differentiation in response to extracellular signals

Gene Ontology (GO) - Molecular Function for SKIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10531062
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 10531062
GO:0003677 NOT DNA binding IDA 10531062
GO:0003682 chromatin binding ISS --
GO:0003714 transcription corepressor activity IDA 10531062
genes like me logo Genes that share ontologies with SKIL: view
genes like me logo Genes that share phenotypes with SKIL: view

Animal Models for SKIL Gene

MGI Knock Outs for SKIL:

miRNA for SKIL Gene

miRTarBase miRNAs that target SKIL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SKIL Gene

Localization for SKIL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKIL Gene COMPARTMENTS Subcellular localization image for SKIL gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SKIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IDA 14712482
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 16109768
GO:0016605 PML body IDA 19383336
genes like me logo Genes that share ontologies with SKIL: view

Pathways for SKIL Gene

genes like me logo Genes that share pathways with SKIL: view

Pathways by source for SKIL Gene

Gene Ontology (GO) - Biological Process for SKIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0001825 blastocyst formation IEA --
GO:0002260 lymphocyte homeostasis IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SKIL: view

Compounds for SKIL Gene

(2) Novoseek inferred chemical compound relationships for SKIL Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 49 2
lysine 0.732 3
genes like me logo Genes that share compounds with SKIL: view

Transcripts for SKIL Gene

Unigene Clusters for SKIL Gene

SKI-like oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKIL Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: -
SP3:
SP4: - -

Relevant External Links for SKIL Gene

GeneLoc Exon Structure for
SKIL
ECgene alternative splicing isoforms for
SKIL

Expression for SKIL Gene

mRNA expression in normal human tissues for SKIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SKIL Gene

SOURCE GeneReport for Unigene cluster for SKIL Gene Hs.536655

mRNA Expression by UniProt/SwissProt for SKIL Gene

P12757-SKIL_HUMAN
Tissue specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.
genes like me logo Genes that share expressions with SKIL: view

Orthologs for SKIL Gene

This gene was present in the common ancestor of animals.

Orthologs for SKIL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKIL 36
  • 99.51 (n)
  • 99.56 (a)
SKIL 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKIL 36
  • 91.26 (n)
  • 91.07 (a)
SKIL 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKIL 36
  • 90.63 (n)
  • 91.65 (a)
SKIL 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skil 36
  • 85.48 (n)
  • 89.19 (a)
Skil 16
Skil 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKIL 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKIL 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Skil 36
  • 85.62 (n)
  • 89.81 (a)
chicken
(Gallus gallus)
Aves SKIL 36
  • 75.16 (n)
  • 75.85 (a)
SKIL 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKIL 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia skil 36
  • 70.51 (n)
  • 72.48 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100007653 36
  • 54.7 (n)
  • 52.82 (a)
skila 37
  • 49 (a)
OneToMany
skilb 37
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Snoo 37
  • 16 (a)
OneToMany
CG7233 38
  • 46 (a)
Species with no ortholog for SKIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKIL Gene

ENSEMBL:
Gene Tree for SKIL (if available)
TreeFam:
Gene Tree for SKIL (if available)

Paralogs for SKIL Gene

Paralogs for SKIL Gene

Selected SIMAP similar genes for SKIL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SKIL: view

Variants for SKIL Gene

Sequence variations from dbSNP and Humsavar for SKIL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs15709 -- 170,392,741(-) TTCCA(A/T)CACAT utr-variant-3-prime
rs1045210 -- 170,396,290(+) TAGTA(A/C)ACATG utr-variant-3-prime
rs1047308 -- 170,359,679(-) GGGGG(A/G)TTGGG utr-variant-5-prime, intron-variant
rs1511174 -- 170,358,045(+) GGAGC(C/T)GCGGG upstream-variant-2KB, intron-variant
rs1511175 -- 170,358,218(+) TGGCG(C/G)GGGGA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKIL Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
nsv519286 CNV Loss 19592680

Relevant External Links for SKIL Gene

HapMap Linkage Disequilibrium report
SKIL

Disorders for SKIL Gene

(9) Novoseek inferred disease relationships for SKIL Gene

Disease -log(P) Hits PubMed IDs
nephropathy obstructive 66.6 3
cancer 29 15
melanoma 15.7 10
tumors 5.23 8
breast carcinoma 2.11 3

Relevant External Links for SKIL

Genetic Association Database (GAD)
SKIL
Human Genome Epidemiology (HuGE) Navigator
SKIL
Tumor Gene Database (TGDB):
SKIL
genes like me logo Genes that share disorders with SKIL: view

No data available for UniProtKB/Swiss-Prot for SKIL Gene

Publications for SKIL Gene

  1. SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno. (PMID: 8233802) Pearson-White S. (Nucleic Acids Res. 1993) 3 4 23
  2. Proto-oncogene Sno expression, alternative isoforms and immediate early serum response. (PMID: 9207045) Pearson-White S.H. … Crittenden R. (Nucleic Acids Res. 1997) 3 4 23
  3. Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). (PMID: 15221015) Komuro A. … Miyazawa K. (Oncogene 2004) 3 4 23
  4. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. (PMID: 17591695) Levy L. … Hill C.S. (Mol. Cell. Biol. 2007) 3 4 23
  5. Isolation of human cDNA clones of ski and the ski-related gene, sno. (PMID: 2762147) Nomura N. … Ishizaki R. (Nucleic Acids Res. 1989) 2 3 4

Products for SKIL Gene

  • Addgene plasmids for SKIL

Sources for SKIL Gene

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