Aliases for SKIL Gene
External Ids for SKIL Gene
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SKIL Gene
SKIL (SKI-Like Proto-Oncogene) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is SKI.
UniProtKB/Swiss-Prot for SKIL Gene
May have regulatory role in cell division or differentiation in response to extracellular signals