SKIL Gene
protein-coding GIFtS: 59
GCID: GC03P170075
|
|
SKI-like oncogene
| |
Aliases
for SKIL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SKI-Like Oncogene1 2 | | Ski-Like Protein2 | | SNO1 2 3 | | Ski-Related Oncogene SnoN2 | | SnoA1 2 | | Ski-Related Oncogene3 | | SnoN1 2 | | Ski-Related Protein3 | | SnoI2 | | |
Export aliases for SKIL gene to outside databasesPrevious GC identifers: GC03P167219 GC03P171126 GC03P171479 GC03P171398 GC03P171396 GC03P171558 GC03P167445 |
Summaries
for SKIL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SKIL:
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiationthrough transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoterregion of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter thenucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding threedifferent isoforms have been found for this gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: SKIL_HUMAN, P12757Function: May have regulatory role in cell division or differentiation in response to extracellular signals
Gene Wiki entry for SKIL
|
Genomic Views
for SKIL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SKIL gene promoter:
Sp1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SKIL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKIL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26 Ensembl cytogenetic band: 3q26.2 HGNC cytogenetic band: 3q26SKIL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P170075: view genomic region
(about GC identifiers)
Start:
|
170,075,466 bp from pter |
End:
|
170,114,623 bp from pter |
Size:
|
39,158 bases |
Orientation:
|
plus strand |
|
Proteins
for SKIL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SKIL_HUMAN, P12757 (See
protein sequence)Recommended Name: Ski-like protein Size: 684 amino acids; 76976 Da
Subunit: Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1
1 PDB 3D structure from  and Proteopedia  for SKIL:3EQ5 (3D)
Secondary accessions: A6NGT1 B4DT50 O00464 P12756 Q07501Alternative splicing: 5 isoforms: P12757-1 P12757-2 P12757-3 P12757-4 P12757-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SKIL: NX_P12757
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P12757
SKIL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001138569.1 NP_001138570.1 NP_001234937.1 NP_005405.2
ENSEMBL proteins: ENSP00000417670 ENSP00000259119 ENSP00000406520 ENSP00000400193 ENSP00000415243 ENSP00000418237 Reactome Protein details: P12757
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SKIL for ontologies About GeneDecksing
SKIL Antibody Products:
Assay Products for SKIL: |
Protein
Domains /
Families
for SKIL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SKIL for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P12757ProtoNet protein and cluster: P12757 3 Blocks protein families: IPB000770 SAND domain IPB003380 Transforming protein Ski IPB010919 SAND-like
UniProtKB/Swiss-Prot: SKIL_HUMAN, P12757Similarity: Belongs to the SKI family |
Function
for SKIL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SKIL_HUMAN, P12757Function: May have regulatory role in cell division or differentiation in response to extracellular signals
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKIL (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKIL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SKIL (NM_001145098) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SKIL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKIL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKIL |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
SKIL for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SKIL: Skiltm1Sis Skiltm1Spw
8 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Skil):
SKIL for phenotypes About GeneDecksing
|
Pathways & Interactions
for SKIL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | | | 2 | Development_TGF-beta receptor signaling | | | 3 | Generic Transcription Pathway | | | 4 | TGF-beta/Smad Signaling | | | 5 | Transcriptional Regulatory Network in Embryonic Stem Cell | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for SKIL
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SKIL
1 
Cell Signaling Technology (CST) Pathway for SKIL
1  GeneGo (Thomson Reuters) Pathway for SKIL
4  BioSystems Pathways for SKIL
5/7 
Reactome Pathways for SKIL (see all 7)
SKIL for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SKIL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/136 Interacting proteins for SKIL (P127572, 3 ENSP000002591194) via UniProtKB, MINT, STRING, and/or I2D (see all 136)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SMAD2 | Q157962, 3, ENSP000002621604 | MINT-60921 MINT-61636 I2D:
score=6 STRING: ENSP00000262160 | | SMAD3 | P840222, 3, ENSP000003329734 | MINT-61640 I2D:
score=5 STRING: ENSP00000332973 | | NCOR1 | O753762, 3, ENSP000002687124 | MINT-61662 I2D:
score=4 STRING: ENSP00000268712 | | FBLN1 | P231422, 3, ENSP000003315444 | MINT-61641 I2D:
score=3 STRING: ENSP00000331544 | | HEYL | Q9NQ872, 3, ENSP000003619434 | MINT-61635 I2D:
score=3 STRING: ENSP00000361943 |
About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | -- | | GO:0001825 | blastocyst formation |
IEA | -- | | GO:0002260 | lymphocyte homeostasis |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- |
SKIL for ontologies About GeneDecksing
|
Drugs & Compounds
for SKIL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SKIL for compounds About GeneDecksing
 Browse Tocris compounds for SKIL
2 Novoseek chemical compound relationships for SKIL gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tgf beta1 |
49 |
3 |
16871886 (2) |
| lysine |
0.732 |
4 |
11691834 (2), 16966324 (1) |
Search CenterWatch for drugs/clinical trials and news about SKIL
|
Transcripts
for SKIL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SKIL gene (4 alternative transcripts): NM_001145097.2 NM_001145098.2 NM_001248008.1 NM_005414.4 Unigene Clusters for SKIL: SKI-like oncogene Hs.536655 [show with all ESTs], Hs.581632 [show with all ESTs]Unigene Representative Sequences: NM_005414, JX10316410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000477216 ENST00000465590 ENST00000476188 ENST00000259119 ENST00000426052
ENST00000490989 ENST00000413427 ENST00000458537(uc011bps.2 uc003fgu.3 uc003fgv.3 uc003fgw.3)
ENST00000470571 ENST00000490894
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKIL (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKIL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SKIL (NM_001145098) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SKIL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKIL |
Additional cDNA sequence: JX103164.1 12 DOTS entries: DT.209925 DT.97804150 DT.99999851 DT.100783679 DT.91892330 DT.120907416 DT.91800467 DT.100748962 DT.92423425 DT.100751003 DT.91731303 DT.95271121 24/213 AceView cDNA sequences (see all 213): H40632 AW614948 AA017059 AU132165 AA280815 AW779041 AA280992 AW079702 AW662250 AA862980 AI827162 U70730 AA513300 AA278329 AI346562 X15219 CB215755 BF434248 CA418219 AW778903 AA953430 AI358240 AI784324 AW294869
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SKIL About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for SKIL
|
Expression
for SKIL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SKIL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SKIL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SKIL
SOURCE GeneReport for Unigene clusters: Hs.536655 Hs.581632
UniProtKB/Swiss-Prot: SKIL_HUMAN, P12757Tissue specificity: Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle,followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restrictedto skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including SKIL:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKIL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SKIL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKIL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKIL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKIL |
Orthologs
for SKIL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SKIL gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SKIL1 |
SKI-like oncogene |
75.23(n)
76.07(a) |
|
396087 NM_205174.2 NP_990505.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SKIL6 |
-- |
72(a) |
1 ↔ 1 |
3(7585446-7614632) |
zebrafish
(Danio rerio) |
Actinopterygii |
skilb1 |
SKI-like oncogene b |
52.5(n)
48.28(a) |
|
100170835 NM_001130669.1 NP_001124141.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG72333 |
-- |
46(a) |
|
28D3 -- |
ENSEMBL Gene Tree for SKIL (if available)
TreeFam Gene Tree for SKIL (if available) |
Paralogs
for SKIL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SKIL gene
- SKI2 SKOR22 SKOR12
1 SIMAP similar gene for SKIL using alignment to 4 protein entries: SKIL_HUMAN (see all proteins):SKI
SKIL for paralogs About GeneDecksing
|
Genomic Variants
for SKIL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SKIL (170075466 - 170114623 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SKIL: -- | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing SKIL: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SKIL |
|
Disorders
/ Diseases
for SKIL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SKIL for disorders About GeneDecksing
OMIM gene information: 165340
OMIM disorders: --
20/21  diseases for SKIL (see all 21): About MalaCardsbarrett's esophagus esophageal squamous cell carcinoma squamous cell carcinoma malignant glioma
breast carcinoma colorectal cancer nephropathy esophagitis
scleroderma carcinoma hepatocellular carcinoma esophageal cancer
ovarian cancer retinoblastoma melanoma fibrosis
thyroiditis adenocarcinoma pancreatitis hepatitis
9 Novoseek disease relationships for SKIL gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nephropathy obstructive |
66.6 |
3 |
16959829 (1), 15537870 (1), 17625116 (1) |
| cancer |
29 |
23 |
16109768 (2), 17074815 (2), 16314499 (2), 18537639 (1) (see all 12) |
| melanoma |
15.7 |
11 |
18782659 (5), 15809735 (3), 16845326 (2) |
| tumors |
5.23 |
11 |
10705283 (2), 12941827 (1), 18212064 (1), 12764135 (1) (see all 7) |
| breast carcinoma |
2.11 |
3 |
12941827 (3) |
| colorectal cancer |
0.739 |
3 |
17062133 (1), 19096149 (1) |
| leukemia |
0 |
4 |
19745809 (1), 19920850 (1) |
| breast cancer |
0 |
5 |
12941827 (2), 17074815 (1) |
| carcinoma |
0 |
7 |
19096149 (2) |
Human Genome Epidemiology (HuGE) Navigator: SKIL (1 document)
Tumor Gene Database (TGDB): SKIL
Export disorders for SKIL gene to outside databases
|
Publications
for SKIL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SKIL gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with SKIL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of human cDNA clones of ski and the ski-related gene, sno. (PubMed id 2762147)1, 2, 3 Nomura N.... Ishizaki R. (1989)
- SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno. (PubMed id 8233802)1, 2, 9 Pearson-White S. (1993)
- Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. (PubMed id 17591695)1, 2, 9 Levy L.... Hill C.S. (2007)
- Proto-oncogene Sno expression, alternative isoforms and immediate early serum response. (PubMed id 9207045)1, 2, 9 Pearson-White S.H. and Crittenden R. (1997)
- Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). (PubMed id 15221015)1, 2, 9 Komuro A....Miyazawa K. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sumoylated SnoN represses transcription in a promoter-specific manner. (PubMed id 16966324)1, 9 Hsu Y.H....Bonni S. (2006)
- Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. (PubMed id 16959829)1, 9 Tan R....Liu Y. (2006)
- Dual role of SnoN in mammalian tumorigenesis. (PubMed id 17074815)1, 9 Zhu Q....Luo K. (2007)
- Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. (PubMed id 16109768)1, 9 Krakowski A.R....Luo K. (2005)
|
External Searches for SKIL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SKIL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SKIL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SKIL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SKIL gene:
Search GeneIP for patents involving SKIL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SKIL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for SKIL | | OriGene shRNA RFP for SKIL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SKIL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SKIL | | | OriGene Protein Over-expression Lysate for SKIL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SKIL | | OriGene 3'-UTR Clone for SKIL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SKIL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SKIL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SKIL | | OriGene Custom Protein Services for SKIL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SKIL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SKIL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKIL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SKIL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKIL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SKIL |
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| | Antibodies & Assays for SKIL |
| | | | Search Tocris compounds for SKIL |
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 | | | SKIL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKIL |
|  |  |  | | | | ThermoFisher Antibodies for SKIL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKIL |
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