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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SKIDA1 Gene

protein-coding   GIFtS: 33
GCID: GC10M021802

SKI/DACH Domain Containing 1

(Previous name: chromosome 10 open reading frame 140)
(Previous symbol: C10orf140)
  Search for SKIDA1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SKI/DACH Domain Containing 11 2     DLN-12
C10orf1401 2 3     SKI/DACH Domain-Containing Protein 12
Protein DLN-12 3     DLN13
Chromosome 10 Open Reading Frame 1401     

External Ids:    HGNC: 326971   Entrez Gene: 3876402   Ensembl: ENSG000001805927   UniProtKB: Q1XH103   

Export aliases for SKIDA1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SKIDA1 Gene: 
SKIDA1 (SKI/DACH domain containing 1) is a protein-coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is C17orf96.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SKIDA1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SKIDA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKIDA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.31   Ensembl cytogenetic band:  10p12.31   HGNC cytogenetic band: 10p12.31

SKIDA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKIDA1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M021802:  view genomic region     (about GC identifiers)

Start:
21,802,407 bp from pter      End:
21,814,611 bp from pter
Size:
12,205 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SKDA1_HUMAN, Q1XH10 (See protein sequence)
Recommended Name: SKI/DACH domain-containing protein 1  
Size: 827 amino acids; 90476 Da
Secondary accessions: B1ANA5 Q6ZMX4 Q8N3C3

Explore the universe of human proteins at neXtProt for SKIDA1: NX_Q1XH10

Explore proteomics data for SKIDA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus (DLN1)
  • View neXtProt modification sites for NX_Q1XH10

  • SKIDA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SKIDA1 Protein Expression
    REFSEQ proteins: NP_997254.3  
    ENSEMBL proteins: 
     ENSP00000410041   ENSP00000442432  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SKIDA1 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009061 DNA-bd_dom_put
     IPR003380 Transform_Ski

    Graphical View of Domain Structure for InterPro Entry Q1XH10

    ProtoNet protein and cluster: Q1XH10

    UniProtKB/Swiss-Prot: SKDA1_HUMAN, Q1XH10
    Similarity: Belongs to the DACH/dachshund family


    SKIDA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
         
    SKIDA1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SKIDA1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SKIDA1 (ENSP000004100414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SKIDA1 (SKDA1)

    Search CenterWatch for drugs/clinical trials and news about SKIDA1 / SKDA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SKIDA1 gene: 
    NM_207371.3  

    Unigene Cluster for SKIDA1:

    SKI/DACH domain containing 1
    Hs.350848  [show with all ESTs]
    Unigene Representative Sequence: NM_207371
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449193(uc009xkd.3) ENST00000487107 ENST00000444772
    miRNA
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    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AB234866.1 AK055656.1 AK127130.1 AK131456.1 AK299717.1 AL834446.1 BC142633.1 

    3 DOTS entries:

    DT.101974978  DT.40257672  DT.75153595 

    7 AceView cDNA sequences:

    NM_207371 AL834446 AK131456 BE250228 AA723015 AI363206 BI497298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SKIDA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SKIDA1 Expression
    About this image


    See SKIDA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SKIDA1

    SOURCE GeneReport for Unigene cluster: Hs.350848
        SABiosciences Custom PCR Arrays for SKIDA1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKIDA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SKIDA1 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skida11 , 5 RIKEN cDNA 2810030E01 gene5
    SKI/DACH domain containing 11
    93.24(n)1
    93.58(a)1
      2 (12.83 cM)5
    726681  NM_028317.21  NP_082593.21 
     180406765 
    chicken
    (Gallus gallus)
    Aves SKIDA11 SKI/DACH domain containing 1 75.41(n)
    71.66(a)
      420510  XM_418611.3  XP_418611.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    46(a)
    possible ortholog
    6(16717694-16720269)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.93272 Transcribed sequence with weak similarity to protein more 79.05(n)    BX698576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL722971.12   -- 77.44(n)    AL722971.1 


    ENSEMBL Gene Tree for SKIDA1 (if available)
    TreeFam Gene Tree for SKIDA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SKIDA1 gene
    C17orf962  

    SKIDA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: SKDA1_HUMAN, Q1XH10
    Polymorphism: The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary


    10/242 SNPs in SKIDA1 are shown (see all 242)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814755311,2
    --21802139(+) TCACTG/TATCTC 1 -- int10--------
    rs1846015651,2
    --21802265(+) CGTCAC/TATAGT 1 -- int10--------
    rs1450099621,2
    --21802310(+) TCTTTC/TAGGCA 1 -- int10--------
    rs1893599041,2
    --21802364(+) TTAACC/TGTTCT 1 -- int10--------
    rs1822300161,2
    --21802643(+) GGATGG/TTCTGA 1 -- ut310--------
    rs70796721,2
    C,F,A,H--21802654(+) AAACAC/GAAGTT 1 -- ut315Minor allele frequency- G:0.08NS EA WA 536
    rs1860225761,2
    --21802675(+) GCAGAA/GAAAGT 1 -- ut310--------
    rs71004711,2
    C,F,H--21802741(+) CTGTTA/GTTTTT 1 -- ut317Minor allele frequency- G:0.11NS NA WA 1010
    rs1909418531,2
    --21802818(+) TATCAA/GGAGTT 1 -- ut310--------
    rs1387939351,2
    --21802901(+) CACTTC/TGGGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SKIDA1 (21802407 - 21814611 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SKIDA1: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SKIDA1
    DNA2.0 Custom Variant and Variant Library Synthesis for SKIDA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SKIDA1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SKIDA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GWAS meta-analysis and replication identifies three ne w susceptibility loci for ovarian cancer. (PubMed id 23535730)1 Pharoah P.D....Sellers T.A. (2013)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    3. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. (PubMed id 7829101)1 Robertson N.G....Morton C.C. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387640 HGNC: 32697 AceView: FLJ45187 Ensembl:ENSG00000180592 euGenes: HUgn387640
    ECgene: SKIDA1 H-InvDB: SKIDA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SKIDA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SKIDA1 gene:
    Search GeneIP for patents involving SKIDA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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