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Aliases for SKIDA1 Gene

Aliases for SKIDA1 Gene

  • SKI/DACH Domain Containing 1 2 3 5
  • Protein DLN-1 3 4
  • C10orf140 3 4
  • Chromosome 10 Open Reading Frame 140 2
  • SKI/DACH Domain-Containing Protein 1 3
  • DLN-1 3
  • DLN1 4

External Ids for SKIDA1 Gene

Previous HGNC Symbols for SKIDA1 Gene

  • C10orf140

Previous GeneCards Identifiers for SKIDA1 Gene

  • GC10M021802

Summaries for SKIDA1 Gene

GeneCards Summary for SKIDA1 Gene

SKIDA1 (SKI/DACH Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is C17orf96.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKIDA1 Gene

Genomics for SKIDA1 Gene

Regulatory Elements for SKIDA1 Gene

Enhancers for SKIDA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SKIDA1 on UCSC Golden Path with GeneCards custom track

Promoters for SKIDA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SKIDA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SKIDA1 Gene

21,510,754 bp from pter
21,527,188 bp from pter
16,435 bases
Minus strand

Genomic View for SKIDA1 Gene

Genes around SKIDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKIDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKIDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIDA1 Gene

Proteins for SKIDA1 Gene

  • Protein details for SKIDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SKI/DACH domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B1ANA5
    • Q6ZMX4
    • Q8N3C3

    Protein attributes for SKIDA1 Gene

    827 amino acids
    Molecular mass:
    90476 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SKIDA1 Gene

Post-translational modifications for SKIDA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKIDA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SKIDA1 Gene

Domains & Families for SKIDA1 Gene

Protein Domains for SKIDA1 Gene

Suggested Antigen Peptide Sequences for SKIDA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DACH/dachshund family.
  • Belongs to the DACH/dachshund family.
genes like me logo Genes that share domains with SKIDA1: view

No data available for Gene Families for SKIDA1 Gene

Function for SKIDA1 Gene

genes like me logo Genes that share phenotypes with SKIDA1: view

Animal Models for SKIDA1 Gene

MGI Knock Outs for SKIDA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKIDA1 Gene

Localization for SKIDA1 Gene

Subcellular locations from

Jensen Localization Image for SKIDA1 Gene COMPARTMENTS Subcellular localization image for SKIDA1 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SKIDA1 Gene

Pathways & Interactions for SKIDA1 Gene

SuperPathways for SKIDA1 Gene

No Data Available

Interacting Proteins for SKIDA1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000410041 Q1XH10-SKDA1_HUMAN for SKIDA1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SKIDA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SKIDA1 Gene

Drugs & Compounds for SKIDA1 Gene

No Compound Related Data Available

Transcripts for SKIDA1 Gene

mRNA/cDNA for SKIDA1 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SKIDA1 Gene

SKI/DACH domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKIDA1 Gene

No ASD Table

Relevant External Links for SKIDA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SKIDA1 Gene

mRNA expression in normal human tissues for SKIDA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SKIDA1 Gene:


SOURCE GeneReport for Unigene cluster for SKIDA1 Gene:

genes like me logo Genes that share expression patterns with SKIDA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SKIDA1 Gene

Orthologs for SKIDA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKIDA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SKIDA1 34
  • 96.08 (n)
  • 95.59 (a)
  • 89 (a)
(Mus musculus)
Mammalia Skida1 34
  • 92.06 (n)
  • 92.36 (a)
Skida1 16
Skida1 35
  • 92 (a)
(Pan troglodytes)
Mammalia SKIDA1 34
  • 99.42 (n)
  • 99.14 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Skida1 34
  • 94.06 (n)
  • 91.27 (a)
(Bos Taurus)
Mammalia SKIDA1 35
  • 76 (a)
(Monodelphis domestica)
Mammalia SKIDA1 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia SKIDA1 35
  • 78 (a)
(Gallus gallus)
Aves C2H10ORF140 34
  • 77.38 (n)
  • 74.02 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9327 34
(Danio rerio)
Actinopterygii SKIDA1 35
  • 42 (a)
Species where no ortholog for SKIDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKIDA1 Gene

Gene Tree for SKIDA1 (if available)
Gene Tree for SKIDA1 (if available)

Paralogs for SKIDA1 Gene

Paralogs for SKIDA1 Gene

genes like me logo Genes that share paralogs with SKIDA1: view

Variants for SKIDA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SKIDA1 Gene

The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary.

Sequence variations from dbSNP and Humsavar for SKIDA1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3758595 -- 21,523,882(-) TCCCG(C/G)TTTTT intron-variant, upstream-variant-2KB
rs4083949 -- 21,521,689(+) AATTA(A/C)ATGTG intron-variant
rs7100471 -- 21,513,812(+) CTGTT(A/G)TTTTT utr-variant-3-prime
rs946711 -- 21,517,903(+) TCCTC(A/C)GCCAG utr-variant-5-prime
rs12256551 -- 21,510,797(+) AGGGC(A/C)TGCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SKIDA1 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv135n67 CNV gain 20364138
nsv1052477 CNV gain 25217958
nsv1068291 CNV deletion 25765185
nsv1143624 CNV deletion 24896259
nsv517469 CNV loss 19592680
nsv527055 CNV loss 19592680
nsv550200 CNV loss 21841781
nsv550201 CNV loss 21841781
nsv825289 CNV loss 20364138

Variation tolerance for SKIDA1 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKIDA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for SKIDA1 Gene

Relevant External Links for SKIDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SKIDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKIDA1 Gene

Publications for SKIDA1 Gene

  1. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3 65
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 65
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 65
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 65
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 65

Products for SKIDA1 Gene

Sources for SKIDA1 Gene