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Aliases for SKIDA1 Gene

Aliases for SKIDA1 Gene

  • SKI/DACH Domain Containing 1 2 3 5
  • Protein DLN-1 3 4
  • C10orf140 3 4
  • Chromosome 10 Open Reading Frame 140 2
  • SKI/DACH Domain-Containing Protein 1 3
  • DLN-1 3
  • DLN1 4

External Ids for SKIDA1 Gene

Previous HGNC Symbols for SKIDA1 Gene

  • C10orf140

Previous GeneCards Identifiers for SKIDA1 Gene

  • GC10M021802

Summaries for SKIDA1 Gene

GeneCards Summary for SKIDA1 Gene

SKIDA1 (SKI/DACH Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is EPOP.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKIDA1 Gene

Genomics for SKIDA1 Gene

Regulatory Elements for SKIDA1 Gene

Enhancers for SKIDA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G021505 1.2 ENCODE dbSUPER 11.7 +21.3 21258 1.2 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF143 SP5 ZHX2 SKIDA1 GC10P021497 MLLT10
GH10G021500 0.9 Ensembl ENCODE 11.7 +26.6 26633 1.9 SCRT1 RNF2 SUZ12 TAF1 CHD1 CBX2 RBBP5 ZNF2 SCRT2 ZBTB33 SKIDA1 MLLT10 GC10P021497
GH10G021581 0.8 ENCODE 11 -54.8 -54761 1.4 HDGF PKNOX1 ARID3A EED ZSCAN5C ZNF207 ETV6 RELB IKZF2 MTA2 RNU6-1141P MLLT10 CASC10 MIR1915 SKIDA1 LOC100422524 GC10M021624
GH10G021515 2.7 FANTOM5 ENCODE dbSUPER 1.8 +9.0 8951 6.3 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF263 SP3 CASC10 MIR1915 MLLT10 SKIDA1 GC10P021497
GH10G021522 1.7 FANTOM5 ENCODE dbSUPER 0.7 +0.8 814 7.4 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D MIR1915 CASC10 SKIDA1 MLLT10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SKIDA1 on UCSC Golden Path with GeneCards custom track

Promoters for SKIDA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025402 588 4801 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1

Genomic Location for SKIDA1 Gene

Chromosome:
10
Start:
21,510,754 bp from pter
End:
21,527,188 bp from pter
Size:
16,435 bases
Orientation:
Minus strand

Genomic View for SKIDA1 Gene

Genes around SKIDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKIDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKIDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIDA1 Gene

Proteins for SKIDA1 Gene

  • Protein details for SKIDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1XH10-SKDA1_HUMAN
    Recommended name:
    SKI/DACH domain-containing protein 1
    Protein Accession:
    Q1XH10
    Secondary Accessions:
    • B1ANA5
    • Q6ZMX4
    • Q8N3C3

    Protein attributes for SKIDA1 Gene

    Size:
    827 amino acids
    Molecular mass:
    90476 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SKIDA1 Gene

Post-translational modifications for SKIDA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKIDA1 Gene

No data available for DME Specific Peptides for SKIDA1 Gene

Domains & Families for SKIDA1 Gene

Protein Domains for SKIDA1 Gene

Suggested Antigen Peptide Sequences for SKIDA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1XH10

UniProtKB/Swiss-Prot:

SKDA1_HUMAN :
  • Belongs to the DACH/dachshund family.
Family:
  • Belongs to the DACH/dachshund family.
genes like me logo Genes that share domains with SKIDA1: view

No data available for Gene Families for SKIDA1 Gene

Function for SKIDA1 Gene

genes like me logo Genes that share phenotypes with SKIDA1: view

Animal Models for SKIDA1 Gene

MGI Knock Outs for SKIDA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKIDA1 Gene

Localization for SKIDA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKIDA1 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SKIDA1 Gene

Pathways & Interactions for SKIDA1 Gene

SuperPathways for SKIDA1 Gene

No Data Available

Interacting Proteins for SKIDA1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000410041%0d%0a9606.ENSP00000316578%0d%0a9606.ENSP00000404658%0d%0a
Selected Interacting proteins: Q1XH10-SKDA1_HUMAN ENSP00000410041 for SKIDA1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SKIDA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SKIDA1 Gene

Drugs & Compounds for SKIDA1 Gene

No Compound Related Data Available

Transcripts for SKIDA1 Gene

mRNA/cDNA for SKIDA1 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SKIDA1 Gene

SKI/DACH domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKIDA1 Gene

No ASD Table

Relevant External Links for SKIDA1 Gene

GeneLoc Exon Structure for
SKIDA1
ECgene alternative splicing isoforms for
SKIDA1

Expression for SKIDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SKIDA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SKIDA1 Gene:

SKIDA1

SOURCE GeneReport for Unigene cluster for SKIDA1 Gene:

Hs.350848
genes like me logo Genes that share expression patterns with SKIDA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKIDA1 Gene

Orthologs for SKIDA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKIDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKIDA1 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia SKIDA1 34 35
  • 96.08 (n)
rat
(Rattus norvegicus)
Mammalia Skida1 34
  • 94.06 (n)
mouse
(Mus musculus)
Mammalia Skida1 34 16 35
  • 92.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SKIDA1 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKIDA1 35
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKIDA1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H10ORF140 34
  • 77.38 (n)
SKIDA1 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9327 34
zebrafish
(Danio rerio)
Actinopterygii SKIDA1 35
  • 42 (a)
OneToOne
Species where no ortholog for SKIDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKIDA1 Gene

ENSEMBL:
Gene Tree for SKIDA1 (if available)
TreeFam:
Gene Tree for SKIDA1 (if available)

Paralogs for SKIDA1 Gene

Paralogs for SKIDA1 Gene

genes like me logo Genes that share paralogs with SKIDA1: view

Variants for SKIDA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SKIDA1 Gene

SKDA1_HUMAN-Q1XH10
The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary.

Sequence variations from dbSNP and Humsavar for SKIDA1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000168078 -- 21,522,399(+) CAACA(A/T)TGTAA intron-variant
rs1000332314 -- 21,516,838(+) GTTGA(C/T)CAGAT reference, missense
rs1000460722 -- 21,525,723(+) GGGAT(A/G)AGAGT upstream-variant-2KB
rs1000768811 -- 21,524,169(+) TAAAC(A/G)TCTCT intron-variant
rs1000832887 -- 21,525,437(+) GATGT(A/G)TGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKIDA1 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv135n67 CNV gain 20364138
nsv1052477 CNV gain 25217958
nsv1068291 CNV deletion 25765185
nsv1143624 CNV deletion 24896259
nsv517469 CNV loss 19592680
nsv527055 CNV loss 19592680
nsv550200 CNV loss 21841781
nsv550201 CNV loss 21841781
nsv825289 CNV loss 20364138

Variation tolerance for SKIDA1 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKIDA1 Gene

Human Gene Mutation Database (HGMD)
SKIDA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKIDA1

Disorders for SKIDA1 Gene

Relevant External Links for SKIDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKIDA1

No disorders were found for SKIDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKIDA1 Gene

Publications for SKIDA1 Gene

  1. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah P.D. … Sellers T.A. (Nat. Genet. 2013) 3 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 64
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for SKIDA1 Gene

Sources for SKIDA1 Gene

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