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Aliases for SKIDA1 Gene

Aliases for SKIDA1 Gene

  • SKI/DACH Domain Containing 1 2 3 5
  • Protein DLN-1 3 4
  • C10orf140 3 4
  • Chromosome 10 Open Reading Frame 140 2
  • SKI/DACH Domain-Containing Protein 1 3
  • DLN-1 3
  • DLN1 4

External Ids for SKIDA1 Gene

Previous HGNC Symbols for SKIDA1 Gene

  • C10orf140

Previous GeneCards Identifiers for SKIDA1 Gene

  • GC10M021802

Summaries for SKIDA1 Gene

GeneCards Summary for SKIDA1 Gene

SKIDA1 (SKI/DACH Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is EPOP.

Additional gene information for SKIDA1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKIDA1 Gene

Genomics for SKIDA1 Gene

GeneHancer (GH) Regulatory Elements for SKIDA1 Gene

Promoters and enhancers for SKIDA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I021522 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.9 +0.8 814 7.4 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 MLLT10 SKIDA1 BMI1 MIR1915 CASC10
GH10I022001 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -476.1 -476112 2.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF302 DNAJC1 BMI1 MLLT10 SKIDA1 GC10M021938 GC10P021805
GH10I022228 Enhancer 1.6 FANTOM5 Ensembl ENCODE 10.1 -702.5 -702506 3 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 TRN-GTT2-3 PIR53259 MLLT10 BMI1 COMMD3 SKIDA1 DNAJC1 EBLN1 LOC105376446
GH10I021505 Enhancer 1.1 ENCODE dbSUPER 11.7 +21.3 21258 1.2 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 RXRA SP5 NFYC SKIDA1 GC10P021497 MLLT10
GH10I021723 Enhancer 1.2 Ensembl ENCODE 10.2 -197.4 -197413 2.3 FOXA2 SMAD1 ARNT ARID4B FEZF1 ZNF2 YY1 ZNF766 ZNF213 SP3 MLLT10 BMI1 MIR1915 CASC10 RNU6-1141P SKIDA1 ENSG00000261671 GC10P021711 RN7SKP219
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SKIDA1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SKIDA1 Gene

Genomic Locations for SKIDA1 Gene
chr10:21,510,754-21,527,188
(GRCh38/hg38)
Size:
16,435 bases
Orientation:
Minus strand
chr10:21,802,407-21,814,611
(GRCh37/hg19)

Genomic View for SKIDA1 Gene

Genes around SKIDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKIDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKIDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIDA1 Gene

Proteins for SKIDA1 Gene

  • Protein details for SKIDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1XH10-SKDA1_HUMAN
    Recommended name:
    SKI/DACH domain-containing protein 1
    Protein Accession:
    Q1XH10
    Secondary Accessions:
    • B1ANA5
    • Q6ZMX4
    • Q8N3C3

    Protein attributes for SKIDA1 Gene

    Size:
    827 amino acids
    Molecular mass:
    90476 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SKIDA1 Gene

Post-translational modifications for SKIDA1 Gene

No Post-translational modifications

Other Protein References for SKIDA1 Gene

No data available for DME Specific Peptides for SKIDA1 Gene

Domains & Families for SKIDA1 Gene

Gene Families for SKIDA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SKIDA1 Gene

Suggested Antigen Peptide Sequences for SKIDA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q1XH10

UniProtKB/Swiss-Prot:

SKDA1_HUMAN :
  • Belongs to the DACH/dachshund family.
Family:
  • Belongs to the DACH/dachshund family.
genes like me logo Genes that share domains with SKIDA1: view

Function for SKIDA1 Gene

genes like me logo Genes that share phenotypes with SKIDA1: view

Animal Models for SKIDA1 Gene

MGI Knock Outs for SKIDA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKIDA1 Gene

Localization for SKIDA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKIDA1 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SKIDA1 Gene

Pathways & Interactions for SKIDA1 Gene

SuperPathways for SKIDA1 Gene

No Data Available

Interacting Proteins for SKIDA1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000410041%0d%0a9606.ENSP00000316578%0d%0a9606.ENSP00000404658%0d%0a
Selected Interacting proteins: ENSP00000410041 Q1XH10-SKDA1_HUMAN for SKIDA1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SKIDA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SKIDA1 Gene

Drugs & Compounds for SKIDA1 Gene

No Compound Related Data Available

Transcripts for SKIDA1 Gene

mRNA/cDNA for SKIDA1 Gene

(5) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SKIDA1 Gene

SKI/DACH domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKIDA1 Gene

No ASD Table

Relevant External Links for SKIDA1 Gene

GeneLoc Exon Structure for
SKIDA1
ECgene alternative splicing isoforms for
SKIDA1

Expression for SKIDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SKIDA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SKIDA1 Gene:

SKIDA1

SOURCE GeneReport for Unigene cluster for SKIDA1 Gene:

Hs.350848
genes like me logo Genes that share expression patterns with SKIDA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKIDA1 Gene

Orthologs for SKIDA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKIDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKIDA1 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia SKIDA1 33 34
  • 96.08 (n)
rat
(Rattus norvegicus)
Mammalia Skida1 33
  • 94.06 (n)
mouse
(Mus musculus)
Mammalia Skida1 33 16 34
  • 92.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SKIDA1 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKIDA1 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKIDA1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H10ORF140 33
  • 77.38 (n)
SKIDA1 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9327 33
zebrafish
(Danio rerio)
Actinopterygii SKIDA1 34
  • 42 (a)
OneToOne
Species where no ortholog for SKIDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKIDA1 Gene

ENSEMBL:
Gene Tree for SKIDA1 (if available)
TreeFam:
Gene Tree for SKIDA1 (if available)

Paralogs for SKIDA1 Gene

Paralogs for SKIDA1 Gene

genes like me logo Genes that share paralogs with SKIDA1: view

Variants for SKIDA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SKIDA1 Gene

SKDA1_HUMAN-Q1XH10
The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary.

Sequence variations from dbSNP and Humsavar for SKIDA1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000168078 -- 21,522,399(-) A/T intron_variant
rs1000332314 -- 21,516,838(-) C/T coding_sequence_variant, missense_variant
rs1000460722 -- 21,525,723(-) G/A upstream_transcript_variant
rs1000768811 -- 21,524,169(-) G/A intron_variant
rs1000832887 -- 21,525,437(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SKIDA1 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv135n67 CNV gain 20364138
nsv1052477 CNV gain 25217958
nsv1068291 CNV deletion 25765185
nsv1143624 CNV deletion 24896259
nsv517469 CNV loss 19592680
nsv527055 CNV loss 19592680
nsv550200 CNV loss 21841781
nsv550201 CNV loss 21841781
nsv825289 CNV loss 20364138

Variation tolerance for SKIDA1 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SKIDA1 Gene

Human Gene Mutation Database (HGMD)
SKIDA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKIDA1

Disorders for SKIDA1 Gene

Additional Disease Information for SKIDA1

No disorders were found for SKIDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKIDA1 Gene

Publications for SKIDA1 Gene

  1. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  2. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah PD … Sellers TA (Nature genetics 2013) 3 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58

Products for SKIDA1 Gene

Sources for SKIDA1 Gene

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