Aliases for SKI Gene
External Ids for SKI Gene
Previous GeneCards Identifiers for SKI Gene
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
GeneCards Summary for SKI Gene
SKI (SKI Proto-Oncogene) is a Protein Coding gene. Diseases associated with SKI include Shprintzen-Goldberg Craniosynostosis Syndrome and Goldberg-Shprintzen Syndrome. Among its related pathways are TGF-beta Receptor Signaling (WikiPathways) and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and ubiquitin protein ligase binding. An important paralog of this gene is SKIL.
UniProtKB/Swiss-Prot for SKI Gene
May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.