Aliases for SKAP2 Gene
External Ids for SKAP2 Gene
Previous HGNC Symbols for SKAP2 Gene
Previous GeneCards Identifiers for SKAP2 Gene
The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
GeneCards Summary for SKAP2 Gene
SKAP2 (Src Kinase Associated Phosphoprotein 2) is a Protein Coding gene. Diseases associated with SKAP2 include candida glabrata and tibial neuropathy. Among its related pathways are Cell junction organization. GO annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SKAP1.
UniProtKB/Swiss-Prot for SKAP2 Gene
May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.