Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SKAP2 Gene

Aliases for SKAP2 Gene

  • Src Kinase Associated Phosphoprotein 2 2 3
  • SKAP55R 3 4 6
  • SCAP2 3 4 6
  • Src-Associated Adapter Protein With PH And SH3 Domains 3 4
  • Src Family-Associated Phosphoprotein 2 3 4
  • Retinoic Acid-Induced Protein 70 3 4
  • Pyk2/RAFTK-Associated Protein 3 4
  • SKAP55 Homolog 3 4
  • SKAP-55HOM 3 4
  • SKAP-HOM 3 4
  • PRAP 3 4
  • RA70 3 4
  • SAPS 3 4
  • Src Kinase-Associated Phosphoprotein Of 55-Related Protein 3
  • Src Kinase-Associated Phosphoprotein 55-Related Protein 4
  • Fyn-Associated Phosphoprotein SKAP55 Homologue 3
  • Src Family Associated Phosphoprotein 2 2
  • Src Kinase-Associated Phosphoprotein 2 3

External Ids for SKAP2 Gene

Previous HGNC Symbols for SKAP2 Gene

  • SCAP2

Previous GeneCards Identifiers for SKAP2 Gene

  • GC07M026674

Summaries for SKAP2 Gene

Entrez Gene Summary for SKAP2 Gene

  • The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for SKAP2 Gene

SKAP2 (Src Kinase Associated Phosphoprotein 2) is a Protein Coding gene. Diseases associated with SKAP2 include tarsal tunnel syndrome and oral candidiasis. Among its related pathways are Cell junction organization and Cell junction organization. GO annotations related to this gene include phospholipid binding and SH3/SH2 adaptor activity. An important paralog of this gene is SKAP1.

UniProtKB/Swiss-Prot for SKAP2 Gene

  • May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.

Gene Wiki entry for SKAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKAP2 Gene

Genomics for SKAP2 Gene

Regulatory Elements for SKAP2 Gene

Genomic Location for SKAP2 Gene

Start:
26,657,778 bp from pter
End:
26,995,239 bp from pter
Size:
337,462 bases
Orientation:
Minus strand

Genomic View for SKAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKAP2 Gene

Proteins for SKAP2 Gene

  • Protein details for SKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75563-SKAP2_HUMAN
    Recommended name:
    Src kinase-associated phosphoprotein 2
    Protein Accession:
    O75563
    Secondary Accessions:
    • A4D173
    • Q53GP6
    • Q75MK6
    • Q75MZ4
    • Q9UBZ3
    • Q9UED8

    Protein attributes for SKAP2 Gene

    Size:
    359 amino acids
    Molecular mass:
    41217 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3. May interact with actin (By similarity). Interacts with FYB, which is required for SKAP2 protein stability. Interacts with LAT, GRB2, PTK2B and PRAM1. May interact with FYN, HCK and LYN. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for SKAP2 Gene

neXtProt entry for SKAP2 Gene

Proteomics data for SKAP2 Gene at MOPED

Post-translational modifications for SKAP2 Gene

  • Phosphorylated in resting platelets. Phosphorylated by FYN on Tyr-261 upon T-cell activation (Probable). Dephosphorylated on Tyr-75 by PTPN22.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKAP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SKAP2 Gene

Domains for SKAP2 Gene

Gene Families for SKAP2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for SKAP2 Gene

Graphical View of Domain Structure for InterPro Entry

O75563

UniProtKB/Swiss-Prot:

SKAP2_HUMAN :
  • O75563
Domain:
  • The SH3 domain interacts with FYB and PTK2B
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the SKAP family.
genes like me logo Genes that share domains with SKAP2: view

Function for SKAP2 Gene

Molecular function for SKAP2 Gene

UniProtKB/Swiss-Prot Function: May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.
UniProtKB/Swiss-Prot Induction: By retinoic acid.

Gene Ontology (GO) - Molecular Function for SKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9671755
GO:0005515 protein binding IPI 21719704
genes like me logo Genes that share ontologies with SKAP2: view
genes like me logo Genes that share phenotypes with SKAP2: view

miRNA for SKAP2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SKAP2 Gene

Localization for SKAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKAP2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKAP2 Gene COMPARTMENTS Subcellular localization image for SKAP2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 3
extracellular 2
endosome 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 11390434
genes like me logo Genes that share ontologies with SKAP2: view

Pathways for SKAP2 Gene

genes like me logo Genes that share pathways with SKAP2: view

Pathways by source for SKAP2 Gene

Gene Ontology (GO) - Biological Process for SKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9671755
GO:0007165 signal transduction TAS 9837776
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009967 positive regulation of signal transduction TAS 9671755
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with SKAP2: view

Compounds for SKAP2 Gene

(9) Novoseek inferred chemical compound relationships for SKAP2 Gene

Compound -log(P) Hits PubMed IDs
saquinavir 72.2 4
ritonavir 61.3 3
indinavir 60.1 2
amprenavir 57.7 1
nelfinavir 48.2 1
genes like me logo Genes that share compounds with SKAP2: view

Transcripts for SKAP2 Gene

Unigene Clusters for SKAP2 Gene

Src kinase associated phosphoprotein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKAP2 Gene

No ASD Table

Relevant External Links for SKAP2 Gene

GeneLoc Exon Structure for
SKAP2
ECgene alternative splicing isoforms for
SKAP2

Expression for SKAP2 Gene

mRNA expression in normal human tissues for SKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SKAP2 Gene

This gene is overexpressed in Whole Blood (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SKAP2 Gene

SOURCE GeneReport for Unigene cluster for SKAP2 Gene Hs.200770

mRNA Expression by UniProt/SwissProt for SKAP2 Gene

O75563-SKAP2_HUMAN
Tissue specificity: Ubiquitously expressed. Present in platelets (at protein level).
genes like me logo Genes that share expressions with SKAP2: view

Orthologs for SKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKAP2 35
  • 99.54 (n)
  • 99.72 (a)
SKAP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKAP2 35
  • 91.62 (n)
  • 93.02 (a)
SKAP2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKAP2 35
  • 93.59 (n)
  • 93.59 (a)
SKAP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skap2 35
  • 88.55 (n)
  • 90.78 (a)
Skap2 16
Skap2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKAP2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Skap2 35
  • 88.92 (n)
  • 87.99 (a)
chicken
(Gallus gallus)
Aves SKAP2 35
  • 79.2 (n)
  • 76.72 (a)
SKAP2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKAP2 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9007 35
tropical clawed frog
(Silurana tropicalis)
Amphibia skap2 35
  • 68.31 (n)
  • 62.96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3678 35
zebrafish
(Danio rerio)
Actinopterygii skap2 35
  • 64.76 (n)
  • 60.66 (a)
skap2 36
  • 59 (a)
OneToOne
zgc65975 35
Species with no ortholog for SKAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKAP2 Gene

ENSEMBL:
Gene Tree for SKAP2 (if available)
TreeFam:
Gene Tree for SKAP2 (if available)

Paralogs for SKAP2 Gene

Paralogs for SKAP2 Gene

Selected SIMAP similar genes for SKAP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SKAP2: view

Variants for SKAP2 Gene

Sequence variations from dbSNP and Humsavar for SKAP2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13186 -- 26,668,038(+) ACAAT(A/C)CCTAA intron-variant
rs169873 -- 26,668,907(+) TAGGG(G/T)GGTAT utr-variant-3-prime, intron-variant
rs190033 -- 26,668,959(+) CAGTA(A/G)AAAAT utr-variant-3-prime, intron-variant
rs212838 -- 26,658,575(+) AAAAC(C/T)GACAT intron-variant
rs212839 -- 26,660,611(+) TATCT(G/T)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKAP2 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv830929 CNV Gain 17160897
nsv5672 CNV Loss 18451855
nsv887855 CNV Loss 21882294
nsv507380 CNV Insertion 20534489
esv2734163 CNV Deletion 23290073
esv2734164 CNV Deletion 23290073
esv2734165 CNV Deletion 23290073

Relevant External Links for SKAP2 Gene

HapMap Linkage Disequilibrium report
SKAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKAP2 Gene

Disorders for SKAP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for SKAP2 Gene including...

Search for SKAP2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for SKAP2 Gene

(4) Novoseek inferred disease relationships for SKAP2 Gene

Disease -log(P) Hits PubMed IDs
candidiasis 73.8 5
oral candidiasis 67 2
oropharyngeal 56.8 1
immunodeficiency 21.3 2

Relevant External Links for SKAP2

Genetic Association Database (GAD)
SKAP2
Human Genome Epidemiology (HuGE) Navigator
SKAP2
genes like me logo Genes that share disorders with SKAP2: view

No data available for UniProtKB/Swiss-Prot for SKAP2 Gene

Publications for SKAP2 Gene

  1. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. (PMID: 9755858) Marie-Cardine A. … Schraven B. (FEBS Lett. 1998) 2 3 4 23
  2. RA70 is a src kinase-associated protein expressed ubiquitously. (PMID: 9837776) Kouroku Y. … Momoi T. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. (PMID: 12893833) Takahashi T. … Matsumoto M. (J. Biol. Chem. 2003) 3 4 23
  4. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PMID: 9671755) Liu J. … Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  5. Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin. (PMID: 10942756) Asazuma N. … Watson S.P. (J. Biol. Chem. 2000) 3 4

Products for SKAP2 Gene

Sources for SKAP2 Gene

Back to Top

Content