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SKAP2 Gene

protein-coding   GIFtS: 57
GCID: GC07M026706

Src Kinase Associated Phosphoprotein 2

(Previous name: src family associated phosphoprotein 2)
(Previous symbol: SCAP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src Kinase Associated Phosphoprotein 21 2     SAPS2 3
SCAP21 2 3 5     SKAP-55HOM2 3
SKAP55R2 3 5     SKAP-HOM2 3
Src Family Associated Phosphoprotein 21 2     Pyk2/RAFTK-Associated Protein2 3
Retinoic Acid-Induced Protein 702 3     SKAP55 Homolog2 3
Src Family-Associated Phosphoprotein 22 3     Fyn-Associated Phosphoprotein SKAP55 Homologue2
Src Kinase-Associated Phosphoprotein 55-Related Protein2 3     Src Kinase-Associated Phosphoprotein 22
Src-Associated Adapter Protein With PH And SH3 Domains2 3     Src Kinase-Associated Phosphoprotein Of 55-Related Protein2
PRAP2 3     Src-Associated Adaptor Protein2
RA702 3     

External Ids:    HGNC: 156871   Entrez Gene: 89352   Ensembl: ENSG000000050207   OMIM: 6052155   UniProtKB: O755633   

Export aliases for SKAP2 gene to outside databases

Previous GC identifer: GC07M026674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SKAP2 Gene:
The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase
associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src
signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein
phosphorylation. (provided by RefSeq, Jul 2008)

GeneCards Summary for SKAP2 Gene:
SKAP2 (src kinase associated phosphoprotein 2) is a protein-coding gene. Diseases associated with SKAP2 include tarsal tunnel syndrome, and ulnar neuropathy. GO annotations related to this gene include SH3/SH2 adaptor activity and phospholipid binding. An important paralog of this gene is SKAP1.

UniProtKB/Swiss-Prot: SKAP2_HUMAN, O75563
Function: May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell
receptor (BCR) to integrin activation. May play a role in src signaling pathway

Gene Wiki entry for SKAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SKAP2 gene promoter:
         ER-alpha   LCR-F1   MEF-2A   POU2F1   CBF-A   CBF-B   POU2F1a   CP1A   aMEF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SKAP2 promoter sequence
   Search Chromatin IP Primers for SKAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

SKAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKAP2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M026706:  view genomic region     (about GC identifiers)

Start:
26,706,681 bp from pter      End:
27,034,858 bp from pter
Size:
328,178 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 26,757,875-26,955,499     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SKAP2_HUMAN, O75563 (See protein sequence)
Recommended Name: Src kinase-associated phosphoprotein 2  
Size: 359 amino acids; 41217 Da
Subunit: Homodimer (By similarity). Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB and PTPNS1.
Part of a complex consisting of SKAP2, FYB and LILRB3. May interact with actin (By similarity). Interacts with
FYB, which is required for SKAP2 protein stability. Interacts with LAT, GRB2, PTK2B and PRAM1. May interact with
FYN, HCK and LYN. Interacts with FASLG
1 PDB 3D structure from and Proteopedia for SKAP2:
3OMH (3D)    
Secondary accessions: A4D173 Q53GP6 Q75MK6 Q75MZ4 Q9UBZ3 Q9UED8

Explore the universe of human proteins at neXtProt for SKAP2: NX_O75563

Explore proteomics data for SKAP2 at MOPED

Post-translational modifications: 

  • Phosphorylated in resting platelets. Phosphorylated by FYN on Tyr-261 upon T-cell activation (Probable).
    Dephosphorylated on Tyr-75 by PTPN221
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SKAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003921.2  
    ENSEMBL proteins: 
     ENSP00000005587   ENSP00000408163   ENSP00000443593  
    Reactome Protein details: O75563

    SKAP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SKAP2
    OriGene Protein Over-expression Lysate for SKAP2
    OriGene MassSpec for SKAP2
    OriGene Custom Protein Services for SKAP2
    GenScript Custom Purified and Recombinant Proteins Services for SKAP2
    Novus Biologicals SKAP2 Proteins
    Novus Biologicals SKAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SKAP2

    SKAP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals SKAP2 Antibodies
    Abcam antibodies for SKAP2
    Cloud-Clone Corp. Antibodies for SKAP2
    ThermoFisher Antibodies for SKAP2
    LSBio Antibodies in human, mouse, rat for SKAP2

    SKAP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SKAP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SKAP2
    Cloud-Clone Corp. CLIAs for SKAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O75563

    ProtoNet protein and cluster: O75563

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: SKAP2_HUMAN, O75563
    Domain: The SH3 domain interacts with FYB and PTK2B
    Similarity: Belongs to the SKAP family
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    SKAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKAP2_HUMAN, O75563
    Function: May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell
    receptor (BCR) to integrin activation. May play a role in src signaling pathway
    Induction: By retinoic acid

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity TAS9671755
    GO:0005515protein binding ----
         
    SKAP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SKAP2:
     Decreased DCP1a protein expres 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Skap2):
     hematopoietic system  immune system 

    SKAP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKAP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SKAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SKAP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SKAP2:
    hsa-mir-15a-5p (MIRT003875), hsa-mir-16-5p (MIRT004369), hsa-mir-484 (MIRT042017), hsa-mir-335-5p (MIRT017252)

    Block miRNA regulation of human, mouse, rat SKAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SKAP2 (see all 38):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-642a hsa-miR-4254 hsa-miR-193a-3p hsa-miR-1224-3p hsa-miR-759 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidSKAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SKAP2
    Predesigned siRNA for gene silencing in human, mouse, rat SKAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SKAP2

    Clone
    Products:
         
    OriGene clones in human, mouse for SKAP2 (see all 6)
    OriGene ORF clones in mouse, rat for SKAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SKAP2 (NM_003930)
    Sino Biological Human cDNA Clone for SKAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKAP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SKAP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SKAP2_HUMAN, O75563: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus3
    extracellular2
    endosome1
    golgi apparatus1
    lysosome1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA11390434

    SKAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell-Cell communication0.64
    Signal regulatory protein (SIRP) family interactions0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SKAP2
        Signal regulatory protein (SIRP) family interactions



    SKAP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SKAP2
    Interactions:

        GeneGlobe Interaction Network for SKAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for SKAP2 (O755633 ENSP000000055874) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062413, ENSP000003576564I2D: score=4 STRING: ENSP00000357656
    HCKP086313, ENSP000003650124I2D: score=3 STRING: ENSP00000365012
    FYBO151173, ENSP000003164604I2D: score=1 STRING: ENSP00000316460
    LCKP062393, ENSP000003378254I2D: score=1 STRING: ENSP00000337825
    PRAM1Q96QH23, ENSP000002556124I2D: score=1 STRING: ENSP00000255612
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9671755
    GO:0007165signal transduction TAS9837776
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0009967positive regulation of signal transduction TAS9671755
    GO:0042113B cell activation IEA--

    SKAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SKAP2

    9 Novoseek inferred chemical compound relationships for SKAP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    saquinavir 72.2 5 11476984 (1), 11322888 (1), 17954688 (1), 12621090 (1)
    ritonavir 61.3 4 11476984 (1), 11322888 (1), 17954688 (1)
    indinavir 60.1 2 11476984 (1), 11322888 (1)
    amprenavir 57.7 1 12621090 (1)
    nelfinavir 48.2 1 11322888 (1)
    glycosphingolipid 47.5 1 16618109 (1)
    anti-fungal 21.1 1 12621090 (1)
    aspartate 17.7 3 16897584 (1), 11291571 (1), 9485603 (1)
    tyrosine 0 2 9755858 (1), 12893833 (1)



    SKAP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SKAP2 gene: 
    NM_003930.3  

    Unigene Clusters for SKAP2:

    Src kinase associated phosphoprotein 2
    Hs.200770  [show with all ESTs], Hs.610137  [show with all ESTs]
    Unigene Representative Sequences: NM_003930, BQ708363
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000345317(uc011jzi.2 uc003syc.3 uc011jzj.2) ENST00000489977
    ENST00000468712 ENST00000495802 ENST00000432747 ENST00000490456 ENST00000497511
    ENST00000481204 ENST00000487720 ENST00000539623
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SKAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SKAP2 (see all 38):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-642a hsa-miR-4254 hsa-miR-193a-3p hsa-miR-1224-3p hsa-miR-759 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidSKAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SKAP2
    Predesigned siRNA for gene silencing in human, mouse, rat SKAP2
    Clone
    Products:
         
    OriGene clones in human, mouse for SKAP2 (see all 6)
    OriGene ORF clones in mouse, rat for SKAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SKAP2 (NM_003930)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SKAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SKAP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SKAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for SKAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SKAP2
      QuantiTect SYBR Green Assays in human, mouse, rat SKAP2
      QuantiFast Probe-based Assays in human, mouse, rat SKAP2

    Additional mRNA sequence: 

    AB063661.1 AB063671.1 AB063791.1 AB063873.1 AB063905.1 AB063909.1 AB063910.1 AB063911.1 
    AB066896.1 AB066900.1 AB066905.1 AB066909.1 AB066910.1 AB066914.1 AB066915.1 AB066916.1 
    AB066918.1 AB066919.1 AB066920.1 AB066921.1 AB066923.1 AB066924.1 AB066933.1 AB067034.1 
    AB067035.1 AB067036.1 AB067037.1 AB067038.1 AB067039.1 AB067040.1 AB067041.1 AB067044.1 
    AB067046.1 AB067049.1 AB067052.1 AB067053.1 AB067055.1 AB067056.1 AB067057.1 AB067058.1 
    AB067060.1 AB067064.1 AB067066.1 AB067067.1 AB067068.1 AB067084.1 AB067085.1 AB067088.1 
    AB067089.1 AB067090.1 AB067091.1 AB067092.1 AB067093.1 AB067120.1 AB067132.1 AB067133.1 
    AB067134.1 AB067135.1 AB067136.1 AB067137.1 AB067142.1 AB067143.1 AB067144.1 AB067145.1 
    AB067146.1 AB067148.1 AB067149.1 AB067151.1 AB067271.1 AB067274.1 AB067276.1 AB067278.1 
    AB067279.1 AB067282.1 AB067284.1 AB067289.1 AB067293.1 AB067298.1 AB067300.1 AB363098.1 
    AB363103.1 AB363104.1 AB363113.1 AB363131.1 AB363152.1 AB363153.1 AB363154.1 AB363224.1 
    AB374190.1 AB374203.1 AB374205.1 AB729120.1 AF004936.1 AF004937.1 AF017459.1 AF017460.1 
    AF017461.1 AF017463.1 AF021948.1 AF021954.1 AF021957.1 AF021958.1 AF021975.1 AF021990.1 
    AF021991.1 AF022004.1 AF022005.1 AF052527.1 AF062101.1 AF062102.1 AF062104.1 AF062112.1 
    AF062113.1 AF062124.1 AF062128.1 AF062146.1 AF062148.1 AF062149.1 AF062152.1 AF062158.1 
    AF062173.1 AF062176.1 AF062181.1 AF062183.1 AF062187.1 AF062192.1 AF062196.1 AF062201.1 
    AF062204.1 AF062217.1 AF062218.1 AF062227.1 AF062231.1 AF062234.1 AF062239.1 AF062240.1 
    AF062244.1 AF062250.1 AF062278.1 AF062292.1 AF064878.1 AF064879.1 AF103048.1 AF103053.1 
    AF103061.2 AF103062.1 AF103065.1 AF103083.1 AF103094.1 AF103108.1 AF103173.1 AF103178.1 
    AF103236.1 AF103242.1 AF103277.2 AF103278.1 AF103287.1 AF103289.1 AF103299.1 AF103306.1 
    AF103313.1 AF103337.1 AF103340.1 AF103344.1 AF103362.1 AF103372.1 AF107233.1 AF107238.1 
    AF107239.1 AF107241.1 AF129752.1 AF174022.1 AF174032.1 AF174035.1 AF174041.1 AF174049.1 
    AF174053.1 AF174054.1 AF174078.1 AF174082.1 AF174085.1 AF174086.1 AF174087.1 AF174088.1 
    AF174124.1 AF174128.1 AF245309.2 AF283780.1 AF283781.1 AF283784.1 AF302819.1 AF361025.1 
    AF372845.1 AF396470.1 AF396472.1 AF396478.1 AF398963.1 AF408717.2 AF408738.1 AF417843.1 
    AF417844.1 AF455548.1 AF460681.1 AF460702.1 AF460703.1 AF460708.1 AF460712.1 AF460715.1 
    AF460721.1 AF460728.1 AF460736.1 AF460737.1 AF460739.1 AF460748.1 AF460749.1 AF460750.1 
    AF460752.1 AF460753.1 AF460755.1 AF460757.1 AF460762.1 AF460765.1 AF460785.1 AF460789.1 
    AF460792.1 AF460795.1 AF460796.1 AF460799.1 AF460808.1 AF460809.1 AF460810.1 AF460811.1 
    AF460812.1 AF460813.1 AF460814.1 AF460815.1 AF460816.1 AF460818.1 AF460819.1 AF460820.1 
    AF460821.1 AF460824.1 AF460828.1 AF460831.1 AF460832.1 AF460836.1 AF460837.1 AF460842.1 
    AF460843.1 AF484411.1 AJ008187.1 AJ222547.1 AJ222548.1 AJ222549.1 AJ222550.1 AJ222552.1 
    AJ222555.1 AJ222556.1 AJ222557.1 AJ222558.1 AJ222559.1 AJ222560.1 AJ222561.1 AJ222562.1 
    AJ222563.1 AJ222564.1 AJ222565.1 AJ222566.1 AJ222567.1 AJ222568.1 AJ222569.1 AJ222570.1 
    AJ222571.1 AJ222573.1 AJ222574.1 AJ222575.1 AJ222576.1 AJ222577.1 AJ222578.1 AJ233698.1 
    AJ233713.1 AJ235663.1 AJ239377.1 AJ240555.1 AJ240556.1 AJ240560.1 AJ240580.1 AJ240595.1 
    AJ241346.1 AJ241354.1 AJ241355.1 AJ244928.1 AJ244929.1 AJ244930.1 AJ244931.1 AJ244932.1 
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    DQ454982.1 DQ454986.1 DQ454988.1 DQ454992.1 DQ454995.1 DQ454997.1 DQ454998.1 DQ454999.1 
    DQ455002.1 DQ455005.1 DQ455007.1 DQ523846.1 DQ523847.1 DQ523853.1 DQ523856.1 DQ523861.1 
    DQ523864.1 DQ523868.1 DQ523870.1 DQ523872.1 DQ523875.1 DQ523877.1 DQ523881.1 DQ523882.1 
    DQ523885.1 DQ523886.1 DQ523887.1 DQ523893.1 DQ523894.1 DQ523900.1 DQ523902.1 DQ523906.1 
    DQ523909.1 DQ523912.1 DQ523927.1 DQ523928.1 DQ523929.1 DQ523930.1 DQ523931.1 DQ523933.1 
    DQ523935.1 DQ523946.1 DQ523947.1 DQ523950.1 DQ523952.1 DQ523955.1 DQ523959.1 DQ523960.1 
    DQ523972.1 DQ523975.1 DQ523980.1 DQ523984.1 DQ523987.1 DQ523988.1 DQ523990.1 DQ523991.1 
    DQ523999.1 DQ524000.1 DQ524001.1 DQ524003.1 DQ524006.1 DQ524007.1 DQ524008.1 DQ524009.1 
    DQ524012.1 DQ524017.1 DQ524018.1 DQ524027.1 DQ524030.1 DQ524032.1 DQ524035.1 DQ524038.1 
    DQ524044.1 DQ524060.1 DQ524061.1 DQ524065.1 DQ524068.1 DQ524077.1 DQ524096.1 DQ524102.1 
    DQ524131.1 DQ535279.1 DQ535289.1 DQ535294.1 DQ535296.1 DQ535314.1 DQ535320.1 DQ535326.1 
    DQ535329.1 DQ535370.1 DQ535393.1 DQ535421.1 DQ535427.1 DQ535433.1 DQ535455.1 DQ535456.1 
    DQ535459.1 EF028216.1 EF175396.1 EF175402.1 EF175407.1 EF175421.1 EF175423.1 EF175434.1 
    EF175437.1 EF407837.1 EF407849.1 EF441754.1 EF544958.1 EF583678.1 EF624236.1 EU090050.1 
    EU090244.1 EU099061.1 EU099068.1 EU099071.1 EU099076.1 EU099079.1 EU099089.1 EU099096.1 
    EU099098.1 EU099107.1 EU099109.1 EU099112.1 EU099123.1 EU099126.1 EU099131.1 EU099156.1 
    EU099169.1 EU099191.1 EU099227.1 EU099235.1 EU099252.1 EU099254.1 EU099255.1 EU099259.1 
    EU099267.1 EU099277.1 EU099278.1 EU146315.1 EU146343.1 EU146358.1 EU146377.1 EU146394.1 
    EU350428.1 EU433882.1 EU619988.1 EU620002.1 EU620038.1 EU937522.1 FJ039783.1 FJ039790.1 
    FJ039791.1 FJ039792.1 FJ208782.1 FJ385279.1 FJ385292.1 FJ385328.1 FJ385331.1 FJ385337.1 
    FJ385351.1 FJ385353.1 FJ385370.1 FJ385371.1 FJ385373.1 FJ385377.1 FJ385378.1 FJ385402.1 
    FJ385413.1 FJ385423.1 FJ385434.1 FJ385435.1 FJ492903.1 FJ492909.1 FJ492910.1 FJ840008.1 
    FJ840011.1 FJ840012.1 FJ840020.1 FJ840055.1 FJ840375.1 FJ840414.1 FJ840418.1 FJ840424.1 
    FJ873953.1 FJ874002.1 FJ874054.1 FJ874055.1 FJ874065.1 FJ874066.1 FJ874069.1 FJ874072.1 
    FJ874075.1 FJ874085.1 FJ874088.1 FJ874094.1 FJ874095.1 FR820867.1 FR820868.1 FR820869.1 
    FR820870.1 FR820871.1 FR820872.1 FR820873.1 FR820875.1 GQ504852.1 GQ504930.1 GQ504932.1 
    GQ504940.1 GU358660.1 GU358680.1 GU552721.1 GU552724.1 GU552725.1 GU552726.1 GU552727.1 
    GU552728.1 GU552729.1 GU552730.1 GU552731.1 GU552733.1 GU552736.1 GU552769.1 GU570263.1 
    GU570372.1 GU570373.1 GU570374.1 HM116105.1 HM116113.1 HM116114.1 HM116141.1 HM116146.1 
    HM116153.1 HM116155.1 HM116160.1 HM116162.1 HM116168.1 HM116169.1 HM116177.1 HM116182.1 
    HM116195.1 HM116199.1 HM116205.1 HM116208.1 HM116216.1 HM116219.1 HM116221.1 HM116222.1 
    HM152498.1 HM152499.1 HM152512.1 HM152516.1 HM152518.1 HM152521.1 HM152526.1 HM451490.1 
    HM774720.1 HM774736.1 HM774878.1 HM775069.1 HM994959.1 HM995092.1 HM995219.1 HM995239.1 
    HM995286.1 HM995287.1 HM995289.1 HM995291.1 HM995368.1 HM995370.1 HM995371.1 HM995396.1 
    HM995477.1 HM995479.1 HM995481.1 HM995513.1 HM995535.1 HM995549.1 HM995550.1 HM995552.1 
    HM995553.1 HM995554.1 HM995565.1 HM995651.1 HM995652.1 HM995654.1 HM995687.1 HM995693.1 
    HM995714.1 HM995715.1 HM995717.1 HM995718.1 HM995719.1 HM995720.1 HM995743.1 HM995865.1 
    HM995867.1 HM995920.1 HM996018.1 HM996057.1 HM996061.1 HM996124.1 HM996196.1 HM996197.1 
    HM996199.1 HM996206.1 HM996222.1 HM996223.1 HM996230.1 HM996236.1 HM996238.1 HM996243.1 
    HM996258.1 HM996265.1 HM996279.1 HM996415.1 HM996438.1 HM996480.1 HM996508.1 HM996519.1 
    HM996520.1 HM996535.1 HM996554.1 HQ378388.1 HQ392880.1 HQ392881.1 HQ392885.1 HQ392894.1 
    HQ392917.1 JF810276.1 JF810277.1 JF810279.1 JN110725.1 JN110760.1 JN110800.1 JN110847.1 
    JN110934.1 JN110965.1 JN110999.1 JN376171.1 JN376173.1 JN376176.1 JN376184.1 JN376186.1 
    JN376188.1 JN376189.1 JN376194.1 JN376195.1 JN376215.1 JN376216.1 JN376217.1 JN376224.1 
    JN376225.1 JN376226.1 JN376230.1 JN376231.1 JN376232.1 JN376233.1 JN376234.1 JN376235.1 
    JN376236.1 JN376254.1 JN376255.1 JN376256.1 JN376257.1 JN376266.1 JN376267.1 JN376268.1 
    JN376269.1 JN376285.1 JN376286.1 JN376287.1 JN376304.1 JN376305.1 JN376306.1 JN376310.1 
    JN376361.1 JN376366.1 JN376367.1 JN376411.1 JN376412.1 JN376413.1 JN376414.1 JN376415.1 
    JN376425.1 JN376426.1 JN376427.1 JN376428.1 JN376429.1 JN376436.1 JN376443.1 JN376444.1 
    JN376449.1 JN376461.1 JN376468.1 JN376492.1 JN376506.1 JN376509.1 JN376510.1 JN376511.1 
    JN376512.1 JN376513.1 JN376514.1 JN376515.1 JN376516.1 JN376517.1 JN376518.1 JN376519.1 
    JN376520.1 JN376521.1 JN376522.1 JN376523.1 JN376529.1 JN376530.1 JN376532.1 JN376535.1 
    JN376536.1 JN376537.1 JN376538.1 JN376541.1 JN376542.1 JN376543.1 JN376549.1 JN376614.1 
    JN376615.1 JN376616.1 JN376643.1 JN376644.1 JN376666.1 JN376667.1 JN376688.1 JN376713.1 
    JN376746.1 JN376749.1 JN376753.1 JQ304255.1 JQ304256.1 JQ304259.1 JQ304265.1 JQ304268.1 
    JX027465.1 JX173327.1 JX173330.1 JX173333.1 JX173348.1 JX173350.1 JX173359.1 L06023.1 
    L12109.1 L12190.1 L12192.1 L23518.1 L23556.1 L23934.1 L25291.1 L25293.1 
    L34163.1 L38425.1 L43087.1 L43117.1 M26998.1 M27768.1 M33859.1 M33860.1 
    M67501.1 M74018.1 M74021.1 M74469.1 M84508.1 M84512.1 M99601.1 M99607.1 
    S45207.1 S45947.1 S56197.1 S63731.1 S64473.1 S66098.1 S67110.1 S79918.1 
    U00494.1 U00497.1 U00556.1 U00566.1 U00571.1 U00578.1 U00581.1 U21257.1 
    U21267.1 U21268.1 U22391.1 U64496.1 U71103.1 U71106.1 U85233.1 U86523.1 
    U86524.1 U86799.1 U86800.1 U89766.1 U96278.1 U96280.1 U96285.1 U96287.1 
    U97243.1 U97246.1 X17678.1 X52110.1 X52895.1 X54437.1 X54441.1 X54447.1 
    X56158.1 X64152.1 X64153.1 X64156.1 X64159.1 X64234.1 X64235.1 X65903.1 
    X65904.1 X65911.1 X75022.1 X75024.1 X84336.1 X84339.1 X87438.1 X95660.1 
    Y08428.1 Y09249.1 Y09390.1 Y14936.1 Y17927.1 Y17928.1 Y17930.1 Y17931.1 
    Y17932.1 Y17933.1 Y17934.1 Y17943.1 Y17944.1 Y17945.1 Y17947.1 Y17948.1 
    Y17949.1 Z11941.1 Z14193.1 Z14195.1 Z14197.1 Z14198.1 Z14206.1 Z18828.1 
    Z30545.1 Z30547.1 Z30549.1 Z30550.1 Z30552.1 Z30554.1 Z30557.1 Z30561.1 
    Z30562.1 Z30573.1 Z30576.1 Z30578.1 Z30580.1 Z30581.1 Z30590.1 Z30591.1 
    Z30592.1 Z30596.1 Z30599.1 Z30671.1 Z30674.1 Z30675.1 Z30676.1 Z30677.1 
    Z30678.1 Z35126.1 Z35492.1 Z46269.1 Z46271.1 Z46273.1 Z46275.1 Z46277.1 
    Z46282.1 Z46300.1 Z46301.1 Z46302.1 Z46304.1 Z46305.1 Z46306.1 Z46307.1 
    Z46308.1 Z46315.1 Z46316.1 Z46317.1 Z46318.1 Z46319.1 Z46320.1 Z46321.1 
    Z46322.1 Z46323.1 Z46324.1 Z46325.1 Z46326.1 Z46327.1 Z46328.1 Z46329.1 
    Z46330.1 Z46331.1 Z46332.1 Z46333.1 Z46334.1 Z46335.1 Z46336.1 Z46337.1 
    Z46338.1 Z46339.1 Z46340.1 Z46341.1 Z46342.1 Z46769.1 Z46857.1 Z47228.1 
    Z47229.1 Z47234.1 Z47241.1 Z49135.1 Z49139.1 Z49141.1 Z49143.1 Z70604.1 
    Z70605.1 Z70606.1 Z70607.1 Z70608.1 Z70610.1 Z70616.1 Z70617.1 Z70618.1 
    Z70620.1 Z70621.1 Z70622.1 Z70623.1 Z70624.1 Z70625.1 Z70626.1 Z70627.1 
    Z70631.1 Z70632.1 Z70637.1 Z70638.1 Z70639.1 Z70640.1 Z70641.1 Z70642.1 
    Z70643.1 Z70644.1 Z70645.1 Z70646.1 Z70647.1 Z70648.1 Z70649.1 Z70650.1 
    Z70654.1 Z70655.1 Z70656.1 Z70657.1 Z74665.1 Z74671.1 Z74695.1 Z75362.1 
    Z75364.1 Z75365.1 Z75367.1 Z75369.1 Z75373.1 Z75374.1 Z75376.1 Z75377.1 
    Z75378.1 Z75379.1 Z75381.1 Z75383.1 Z75385.1 Z75387.1 Z75388.1 Z75389.1 
    Z75392.1 Z75394.1 Z75397.1 Z75398.1 

    Selected DOTS entries (see all 871):

    DT.452743  DT.100060883  DT.98083054  DT.100666898  DT.100780946  DT.121651499  DT.100043168  DT.121506031 
    DT.100851394  DT.101987323  DT.121508967  DT.100035517  DT.121650696  DT.121651752  DT.121505803  DT.121508491 
    DT.100039782  DT.100043958  DT.121506265  DT.121509596  DT.91864019  DT.121506460  DT.121508259  DT.121508484 

    Selected AceView cDNA sequences (see all 211):

    BU626415 AI446521 AI278918 BE856248 AA429629 R81282 BC002893 CA423048 
    BG111216 NM_003930 CA396042 AI050841 AW008485 CK002653 AI858173 AF072166 
    CD369002 H72374 CB161041 R81177 AA629098 BQ433993 AA987547 CB111872 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SKAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGCACAG
    SKAP2 Expression
    About this image


    SKAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Lymph (Hematopoietic System)
    SKAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKAP2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.200770 Hs.610137

    UniProtKB/Swiss-Prot: SKAP2_HUMAN, O75563
    Tissue specificity: Ubiquitously expressed. Present in platelets (at protein level)

        Custom PCR Arrays for SKAP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SKAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for SKAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SKAP2
    QuantiTect SYBR Green Assays in human, mouse, rat SKAP2
    QuantiFast Probe-based Assays in human, mouse, rat SKAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for SKAP2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skap21 , 5 src family associated phosphoprotein 21, 5 88.55(n)1
    90.78(a)1
      6 (25.35 cM)5
    543531  NM_018773.21  NP_061243.11 
     518591665 
    chicken
    (Gallus gallus)
    Aves SKAP21 src kinase associated phosphoprotein 2 79.2(n)
    76.72(a)
      420629  XM_418727.4  XP_418727.3 
    lizard
    (Anolis carolinensis)
    Reptilia SKAP26
    src kinase associated phosphoprotein 2
    70(a)
    1 ↔ 1
    GL343275.1(1657982-1786821)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.90072 Xenopus laevis transcribed sequence with moderate similarity more 79.92(n)    CD519925.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659752 hypothetical protein MGC65975 74.65(n)   393601  BC057253.1 


    ENSEMBL Gene Tree for SKAP2 (if available)
    TreeFam Gene Tree for SKAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SKAP2 gene
    SKAP12  
    2 SIMAP similar genes for SKAP2 using alignment to 2 protein entries:     SKAP2_HUMAN (see all proteins):
    SCAP2    SKAP1

    SKAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SKAP2 (see all 3678)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467262861,2
    --26706212(+) AAAAAC/TGAAAC 1 -- ds50010--------
    rs1894835861,2
    --26706279(+) GTCCTA/GTAATA 1 -- ds50010--------
    rs1811792331,2
    --26706316(+) TAGCAC/TACAGT 1 -- ds50010--------
    rs1447988081,2
    C--26706406(+) TGTCA-/TTATGC 1 -- ds50010--------
    rs171542911,2
    C,F,H--26706477(+) AAGTCA/GTTTGT 1 -- ds500113Minor allele frequency- G:0.06NA NS EA WA 1620
    rs1852347311,2
    --26706523(+) GCCCTA/GTTTCA 1 -- ds50010--------
    rs1900863711,2
    --26706623(+) CAAATC/TAATCA 1 -- ds50010--------
    rs1403195561,2
    C--26706626(+) ATTAAG/TCATAA 1 -- ds50010--------
    rs1427142281,2
    C--26706742(+) CATTAG/TTGTAA 1 -- ut310--------
    rs171542951,2
    C,F,H--26706802(+) AAAATG/TCTATA 1 -- ut3112Minor allele frequency- T:0.04NA NS EA WA 1514

    HapMap Linkage Disequilibrium report for SKAP2 (26706681 - 26956681 bp, first 250kb of SKAP2)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SKAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734164CNV Deletion23290073
    esv2734163CNV Deletion23290073
    esv2734165CNV Deletion23290073
    nsv507380CNV Insertion20534489
    nsv887855CNV Loss21882294
    nsv5672CNV Loss18451855
    nsv830929CNV Gain17160897
    nsv7393OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SKAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SKAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605215    OMIM disorders: --

    Selected diseases for SKAP2 (see all 22):    
    About MalaCards
    tarsal tunnel syndrome    ulnar neuropathy    thoracic outlet syndrome    candida glabrata
    vulvovaginal candidiasis    oral candidiasis    candidiasis    vulvovaginitis
    neuronal ceroid lipofuscinosis    lysosomal storage disease    vaginitis    acute promyelocytic leukemia
    neuropathy    periodontitis    type 1 diabetes    inflammatory bowel disease
    pancreatic cancer    neuronitis    tonsillitis    pancreatitis

    3 diseases from the University of Copenhagen DISEASES database for SKAP2:
    Candidiasis     Tarsal tunnel syndrome     Lysosomal storage disease

    SKAP2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SKAP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    candidiasis 73.8 5 11476984 (2), 12182226 (1), 10733678 (1), 12437091 (1)
    oral candidiasis 67 3 11506465 (1), 15472333 (1)
    oropharyngeal 56.8 1 12437091 (1)
    immunodeficiency 21.3 3 17954688 (1), 12621090 (1)

    Genetic Association Database (GAD): SKAP2
    Human Genome Epidemiology (HuGE) Navigator: SKAP2 (5 documents)

    Export disorders for SKAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SKAP2 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with SKAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RA70 is a src kinase-associated protein expressed ubiquitously. (PubMed id 9837776)1, 2, 3, 9 Kouroku Y.... Momoi T. (Biochem. Biophys. Res. Commun. 1998)
    2. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. (PubMed id 9755858)1, 2, 3, 9 Marie-Cardine A.... Schraven B. (FEBS Lett. 1998)
    3. Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. (PubMed id 12893833)1, 2, 9 Takahashi T.... Matsumoto M. (J. Biol. Chem. 2003)
    4. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PubMed id 9671755)1, 2, 9 Liu J.... Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    5. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. (PubMed id 21719704)1, 2 Yu X.... Zhang Z.Y. (J. Biol. Chem. 2011)
    6. In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. (PubMed id 20378605)1, 4 Qu H.Q....Polychronakos C. (Hum. Mol. Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
    9. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8935 HGNC: 15687 AceView: SCAP2 Ensembl:ENSG00000005020 euGenes: HUgn8935
    ECgene: SKAP2 H-InvDB: SKAP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SKAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SKAP2 gene:
    Search GeneIP for patents involving SKAP2

    GeneCards and IP:
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