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SKAP1 Gene

protein-coding   GIFtS: 60
GCID: GC17M046210

Src Kinase Associated Phosphoprotein 1

(Previous name: src family associated phosphoprotein 1)
(Previous symbol: SCAP1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Src Kinase Associated Phosphoprotein 11 2     SKAP-552 3
SCAP11 2 3 5     pp552 3
SKAP552 3 5     HEL-S-81p2
Src Family Associated Phosphoprotein 11 2     Epididymis Secretory Sperm Binding Protein Li 81p2
Src Family-Associated Phosphoprotein 12 3     Src Kinase-Associated Phosphoprotein 12
Src Kinase-Associated Phosphoprotein Of 55 KDa2 3     

External Ids:    HGNC: 156051   Entrez Gene: 86312   Ensembl: ENSG000001412937   OMIM: 6049695   UniProtKB: Q86WV13   

Export aliases for SKAP1 gene to outside databases

Previous GC identifers: GC17M043566 GC17M041580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SKAP1 Gene:
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of
recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a
unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and
degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by
coupling T-cell antigen receptor stimulation to the activation of integrins. (provided by RefSeq, Jul 2008)

GeneCards Summary for SKAP1 Gene:
SKAP1 (src kinase associated phosphoprotein 1) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and protein complex binding. An important paralog of this gene is SKAP2.

UniProtKB/Swiss-Prot: SKAP1_HUMAN, Q86WV1
Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal
conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the
surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells

Gene Wiki entry for SKAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SKAP1 gene promoter:
         AP-1   ATF-2   MyoD   YY1   c-Ets-1   MEF-2A   FAC1   GATA-6   c-Jun   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKAP1 promoter sequence
   Search Chromatin IP Primers for SKAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

SKAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKAP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046210:  view genomic region     (about GC identifiers)

Start:
46,210,802 bp from pter      End:
46,507,637 bp from pter
Size:
296,836 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SKAP1_HUMAN, Q86WV1 (See protein sequence)
Recommended Name: Src kinase-associated phosphoprotein 1  
Size: 359 amino acids; 41432 Da
Subunit: Homodimer. Interacts with FYN and PTPRC. Interacts with GRB2 when phosphorylated on Tyr-271. Interacts
with FYB, which is required for SKAP2 protein stability. Part of a complex consisting of SKAP1, FYB and CLNK.
Interacts with RASGRP1
1 PDB 3D structure from and Proteopedia for SKAP1:
1U5D (3D)    
Secondary accessions: D3DTV1 O15268
Alternative splicing: 2 isoforms:  Q86WV1-1   Q86WV1-2   

Explore the universe of human proteins at neXtProt for SKAP1: NX_Q86WV1

Explore proteomics data for SKAP1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation
    by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC (Probable)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SKAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001068567.1  NP_003717.3  

    ENSEMBL proteins: 
     ENSP00000338171   ENSP00000463284   ENSP00000464509   ENSP00000464311   ENSP00000462360  
     ENSP00000464198   ENSP00000462437  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q86WV1

    ProtoNet protein and cluster: Q86WV1

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: SKAP1_HUMAN, Q86WV1
    Domain: The SH3 domain interacts with FYB
    Similarity: Belongs to the SKAP family
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with SKAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKAP1_HUMAN, Q86WV1
    Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal
    conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the
    surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005070SH3/SH2 adaptor activity IC9195899
    GO:0005515protein binding IPI16461356
    GO:0017124SH3 domain binding TAS11909961
    GO:0019901protein kinase binding IPI9195899
    GO:0019903protein phosphatase binding IPI11909961
         
    Find genes that share ontologies with SKAP1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SKAP1:
     Decreased focal adhesion (FA)   Decreased viability  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Skap1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with SKAP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKAP1
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    SwitchGear 3'UTR luciferase reporter plasmidSKAP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SKAP1

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    GenScript: all cDNA clones in your preferred vector (see all 2): SKAP1 (NM_003726)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SKAP1_HUMAN, Q86WV1: Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts
    at the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    cytoskeleton1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA11909961

    Find genes that share ontologies with SKAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    TCR Signaling Pathway0.36
    2Ras signaling pathway
    Rap1 signaling pathway0.36


    Find genes that share SuperPaths with SKAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SKAP1
        TCR Signaling Pathway



    1 Kegg Pathway  (Kegg details for SKAP1):
        Rap1 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SKAP1
    Interactions:

        GeneGlobe Interaction Network for SKAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SKAP1 (Q86WV11, 2, 3 ENSP000003381714) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYBO151171, 2, 3, ENSP000003164604EBI-2477305,EBI-1753267 MINT-7147955 MINT-7147875 MINT-7148011 MINT-7147926 I2D: score=3 STRING: ENSP00000316460
    FYNP062412, 3, ENSP000003576564MINT-8031426 I2D: score=4 STRING: ENSP00000357656
    GRB2P629932, 3, ENSP000003390074MINT-8031437 I2D: score=4 STRING: ENSP00000339007
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    PTPRCP085753, ENSP000003563464I2D: score=3 STRING: ENSP00000356346
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009967positive regulation of signal transduction IC9195899
    GO:0045893positive regulation of transcription, DNA-templated IMP11909961
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP11909961
    GO:0050852T cell receptor signaling pathway IMP11909961

    Find genes that share ontologies with SKAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for SKAP1

    1 Novoseek inferred chemical compound relationship for SKAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 43 11 10229084 (3), 9195899 (2), 17658605 (2), 9755858 (1) (see all 5)



    Find genes that share compounds with SKAP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SKAP1 gene (2 alternative transcripts): 
    NM_001075099.1  NM_003726.3  

    Unigene Cluster for SKAP1:

    Src kinase associated phosphoprotein 1
    Hs.316931  [show with all ESTs]
    Unigene Representative Sequence: BC039040
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336915 ENST00000584709(uc002ini.1 uc002inj.1 uc010dbd.1)
    ENST00000583844 ENST00000579476 ENST00000584924(uc010dbe.1) ENST00000581400
    ENST00000579336 ENST00000581419
    miRNA
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    hsa-miR-3140-3p hsa-miR-2113 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidSKAP1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SKAP1

    Additional mRNA sequence: 

    AK290818.1 BC039040.1 BC047870.1 Y11215.1 

    6 DOTS entries:

    DT.443453  DT.92420241  DT.95263900  DT.100726926  DT.100748501  DT.438360 

    Selected AceView cDNA sequences (see all 45):

    BC047870 AA342347 AA515886 AA809983 AI216616 BC039040 AA995906 CB157324 
    BM918438 BQ879838 AI760627 CB985047 CD556518 Y11215 NM_003726 CB162087 
    BX099494 AA904648 BI906566 BG197139 BF511972 AA738043 AA342346 AW134687 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SKAP1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
    SP1:                                      -                                                     -                                 
    SP2:                                      -                       -                             -                                 
    SP3:                                                                                                                              
    SP4:                                                        -     -                             -                                 
    SP5:                                                                                      -     -                                 


    ECgene alternative splicing isoforms for SKAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SKAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGGCTGGT
    SKAP1 Expression
    About this image


    SKAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Brain (Nervous System)
             Hippocampus
    SKAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.316931

    UniProtKB/Swiss-Prot: SKAP1_HUMAN, Q86WV1
    Tissue specificity: Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen
    cells and testis. Present in T-cells (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SKAP1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Skap11 , 5 src family associated phosphoprotein 11, 5 86.49(n)1
    82.18(a)1
      11 (59.93 cM)5
    784731  NM_001033186.31  NP_001028358.11 
     964645935 
    chicken
    (Gallus gallus)
    Aves SKAP16
    src kinase associated phosphoprotein 1
    57(a)
    1 ↔ 1
    27(3711055-3815879)
    lizard
    (Anolis carolinensis)
    Reptilia SKAP16
    src kinase associated phosphoprotein 1
    55(a)
    1 ↔ 1
    6(75121061-75133567)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.97002 Transcribed sequence with weak similarity to protein more 78.71(n)    BX691402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii skap11 src kinase associated phosphoprotein 1 58.53(n)
    54.71(a)
      563784  NM_001080011.1  NP_001073480.1 


    ENSEMBL Gene Tree for SKAP1 (if available)
    TreeFam Gene Tree for SKAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SKAP1 gene
    SKAP22  
    3 SIMAP similar genes for SKAP1 using alignment to 6 protein entries:     SKAP1_HUMAN (see all proteins):
    IFT122    SKAP2    SCAP2

    Find genes that share paralogs with SKAP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SKAP1 (see all 4617)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932411681,2
    --46210320(+) CGGGCA/GGCTGA 2 -- ds50010--------
    rs1468170371,2
    C--46210395(+) TCCAGA/CCTGGG 2 -- ds50010--------
    rs72072701,2
    C,F,H--46210434(+) caaacA/Caacaa 2 -- ds50017Minor allele frequency- C:0.12NS EA CSA WA NA 658
    rs1148598941,2
    C,F--46210456(+) AAAATC/GAGCCA 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs38154721,2
    C,F,H--46210773(-) TGTAAA/GATGAT 2 -- ds500125Minor allele frequency- G:0.10NS EA NA WA CSA 2248
    rs3698076091,2
    C--46210972(-) AGCCTA/GGTCAT 2 -- ut310--------
    rs23024771,2
    C,H--46211078(-) CCTCTC/TTTTGC 2 -- ut31 trp35Minor allele frequency- T:0.01NS EA 536
    rs1835682301,2
    --46211365(+) ATATAG/TAGTCT 2 -- int10--------
    rs341027211,2
    C--46211426(+) TTTTT-/TAAACT 2 -- int10--------
    rs1170313421,2
    C,F--46211495(+) GTTGCA/GTAATA 2 -- int11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for SKAP1 (46210802 - 46460802 bp, first 250kb of SKAP1)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SKAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716012CNV Deletion23290073
    esv2658580CNV Deletion23128226
    esv2716013CNV Deletion23290073
    esv268582CNV Insertion20981092
    esv273577CNV Insertion20981092
    esv23897CNV Loss19812545
    nsv833469CNV Loss17160897
    nsv908576CNV Gain21882294
    nsv469808CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SKAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SKAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604969    OMIM disorders: --


    Find genes that share disorders with SKAP1           About GenesLikeMe

    Genetic Association Database (GAD): SKAP1
    Human Genome Epidemiology (HuGE) Navigator: SKAP1 (2 documents)

    Export disorders for SKAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SKAP1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with SKAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of SKAP55, a novel protein that associates with p59fyn in human T-lymphocytes. (PubMed id 9195899)1, 2, 3, 9 Marie-Cardine A....Schraven B. (J. Biol. Chem. 1997)
    2. SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. (PubMed id 17658605)1, 2, 9 Kosco K.A.... Mustelin T. (Mol. Immunol. 2008)
    3. Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. (PubMed id 15849195)1, 2, 9 Huang Y....Wange R.L. (J. Biol. Chem. 2005)
    4. SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. (PubMed id 12171928)1, 2, 9 Wu L.... Shen S.-H. (J. Biol. Chem. 2002)
    5. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. (PubMed id 9748251)1, 2, 9 Marie-Cardine A.... Koretzky G.A. (J. Biol. Chem. 1998)
    6. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PubMed id 9671755)1, 2, 9 Liu J.... Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. (PubMed id 16980616)1, 2, 9 Kliche S.... Schraven B. (Mol. Cell. Biol. 2006)
    8. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (Nat. Genet. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. (PubMed id 16461356)1, 2 Duke-Cohan J.S.... Rudd C.E. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8631 HGNC: 15605 AceView: SCAP1 Ensembl:ENSG00000141293 euGenes: HUgn8631
    ECgene: SKAP1 Kegg: 8631 H-InvDB: SKAP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SKAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SKAP1 gene:
    Search GeneIP for patents involving SKAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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