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Aliases for SKAP1 Gene

Aliases for SKAP1 Gene

  • Src Kinase Associated Phosphoprotein 1 2 3 5
  • Src Kinase-Associated Phosphoprotein Of 55 KDa 3 4
  • Src Family-Associated Phosphoprotein 1 3 4
  • SKAP-55 3 4
  • SKAP55 3 4
  • SCAP1 3 4
  • Pp55 3 4
  • Epididymis Secretory Sperm Binding Protein Li 81p 3
  • Src Family Associated Phosphoprotein 1 2
  • Src Kinase-Associated Phosphoprotein 1 3
  • HEL-S-81p 3

External Ids for SKAP1 Gene

Previous HGNC Symbols for SKAP1 Gene

  • SCAP1

Previous GeneCards Identifiers for SKAP1 Gene

  • GC17M043566
  • GC17M046210
  • GC17M041580

Summaries for SKAP1 Gene

Entrez Gene Summary for SKAP1 Gene

  • This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SKAP1 Gene

SKAP1 (Src Kinase Associated Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are T cell receptor signaling pathway and Ras signaling pathway. GO annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is SKAP2.

UniProtKB/Swiss-Prot for SKAP1 Gene

  • Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Gene Wiki entry for SKAP1 Gene

Additional gene information for SKAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKAP1 Gene

Genomics for SKAP1 Gene

Regulatory Elements for SKAP1 Gene

Enhancers for SKAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H048437 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30.5 -10.3 -10322 5 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 ELK1 ZNF207 ATF7 RUNX3 SKAP1 ENSG00000200538 HOXB1 HOXB2 SNX11 CDK5RAP3 LOC101927166
GH17H048293 2.1 Ensembl ENCODE 19 +135.4 135378 2 ZBTB40 BATF ZNF766 SCRT2 ATF7 RUNX3 IKZF2 CREM ZNF362 JUNB SKAP1 MIR1203 HOXB-AS4 HOXB9 SNX11 CBX1 CDK5RAP3 PRR15L EGID-105371807 ENSG00000266222
GH17H048538 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 16.3 -142.9 -142891 68 FEZF1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN NR2C1 KDM1A UBE2Z ENSG00000264701 HOXB2 CDK5RAP3 SP2 SKAP1 HOXB9 RN7SL125P GIP ENSG00000250838
GH17H048477 1.3 ENCODE dbSUPER 25.8 -48.2 -48191 1 HDGF PKNOX1 ATF1 ARNT FEZF1 TCF12 ZNF766 GATA2 ELK1 ZNF207 SKAP1 HOXB2 HOXB-AS1 HOXB-AS3 HOXB1 SNX11 ENSG00000266601 GC17P048482 LOC101927166
GH17H048491 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.6 -62.4 -62424 2 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 ZNF207 ZNF548 REST HOXB2 SKAP1 RN7SL125P GIP ENSG00000250838 ENSG00000251461 ENSG00000264243 LINC02075 SP2 HOXB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SKAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SKAP1 Gene

Chromosome:
17
Start:
48,133,438 bp from pter
End:
48,430,275 bp from pter
Size:
296,838 bases
Orientation:
Minus strand

Genomic View for SKAP1 Gene

Genes around SKAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKAP1 Gene

Proteins for SKAP1 Gene

  • Protein details for SKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WV1-SKAP1_HUMAN
    Recommended name:
    Src kinase-associated phosphoprotein 1
    Protein Accession:
    Q86WV1
    Secondary Accessions:
    • D3DTV1
    • O15268

    Protein attributes for SKAP1 Gene

    Size:
    359 amino acids
    Molecular mass:
    41432 Da
    Quaternary structure:
    • Homodimer. Interacts with FYN (PubMed:9195899). Interacts with PTPRC (PubMed:11909961). Interacts with GRB2 when phosphorylated on Tyr-271 (PubMed:12171928). Interacts with FYB, which is required for SKAP2 protein stability (PubMed:10856234, PubMed:27335501, PubMed:9671755, PubMed:10856234, PubMed:15849195, PubMed:16461356). Part of a complex consisting of SKAP1, FYB and CLNK (By similarity). Interacts with RASGRP1 (PubMed:17658605). Interacts with ARAP (PubMed:27335501).

    Three dimensional structures from OCA and Proteopedia for SKAP1 Gene

    Alternative splice isoforms for SKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKAP1 Gene

Post-translational modifications for SKAP1 Gene

  • Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC (Probable).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SKAP1 Gene

Domains & Families for SKAP1 Gene

Gene Families for SKAP1 Gene

Protein Domains for SKAP1 Gene

Suggested Antigen Peptide Sequences for SKAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WV1

UniProtKB/Swiss-Prot:

SKAP1_HUMAN :
  • The SH3 domain interacts with FYB.
  • Belongs to the SKAP family.
Domain:
  • The SH3 domain interacts with FYB.
Family:
  • Belongs to the SKAP family.
genes like me logo Genes that share domains with SKAP1: view

Function for SKAP1 Gene

Molecular function for SKAP1 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Phenotypes From GWAS Catalog for SKAP1 Gene

Gene Ontology (GO) - Molecular Function for SKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IC,IBA 9195899
GO:0005515 protein binding IPI 16461356
GO:0017124 SH3 domain binding TAS 11909961
GO:0019901 protein kinase binding IPI 9195899
GO:0019903 protein phosphatase binding IPI 11909961
genes like me logo Genes that share ontologies with SKAP1: view
genes like me logo Genes that share phenotypes with SKAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SKAP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SKAP1 Gene

Localization for SKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKAP1 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKAP1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 11909961
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA,IEA 11909961
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with SKAP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SKAP1 Gene

Pathways & Interactions for SKAP1 Gene

genes like me logo Genes that share pathways with SKAP1: view

Pathways by source for SKAP1 Gene

1 BioSystems pathway for SKAP1 Gene
1 KEGG pathway for SKAP1 Gene

Gene Ontology (GO) - Biological Process for SKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0045785 positive regulation of cell adhesion IEA --
GO:0045893 positive regulation of transcription, DNA-templated IMP 11909961
genes like me logo Genes that share ontologies with SKAP1: view

No data available for SIGNOR curated interactions for SKAP1 Gene

Drugs & Compounds for SKAP1 Gene

(1) Drugs for SKAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SKAP1: view

Transcripts for SKAP1 Gene

Unigene Clusters for SKAP1 Gene

Src kinase associated phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SKAP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SKAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for SKAP1 Gene

GeneLoc Exon Structure for
SKAP1
ECgene alternative splicing isoforms for
SKAP1

Expression for SKAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SKAP1 Gene

This gene is overexpressed in Whole Blood (x9.9).

Protein differential expression in normal tissues from HIPED for SKAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (50.1) and CD8 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SKAP1 Gene



Protein tissue co-expression partners for SKAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SKAP1 Gene:

SKAP1

SOURCE GeneReport for Unigene cluster for SKAP1 Gene:

Hs.316931

mRNA Expression by UniProt/SwissProt for SKAP1 Gene:

Q86WV1-SKAP1_HUMAN
Tissue specificity: Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).

Evidence on tissue expression from TISSUES for SKAP1 Gene

  • Blood(4.4)
  • Pancreas(4.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SKAP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SKAP1 Gene

Orthologs for SKAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKAP1 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia SKAP1 33 34
  • 91.5 (n)
cow
(Bos Taurus)
Mammalia SKAP1 33 34
  • 91.48 (n)
mouse
(Mus musculus)
Mammalia Skap1 33 16 34
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Skap1 33
  • 85.62 (n)
oppossum
(Monodelphis domestica)
Mammalia SKAP1 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKAP1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SKAP1 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKAP1 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia skap1 33
  • 60.98 (n)
Str.9700 33
zebrafish
(Danio rerio)
Actinopterygii skap1 33 34
  • 58.53 (n)
Species where no ortholog for SKAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKAP1 Gene

ENSEMBL:
Gene Tree for SKAP1 (if available)
TreeFam:
Gene Tree for SKAP1 (if available)

Paralogs for SKAP1 Gene

Paralogs for SKAP1 Gene

(3) SIMAP similar genes for SKAP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SKAP1: view

Variants for SKAP1 Gene

Sequence variations from dbSNP and Humsavar for SKAP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000003060 -- 48,192,511(+) AATAT(C/T)ACATT intron-variant
rs1000014850 -- 48,248,384(+) CAACA(C/T)GGTGA intron-variant
rs1000022996 -- 48,402,401(+) CTCAG(C/G)TCACT intron-variant
rs1000024058 -- 48,338,730(+) AACGG(C/G)TCATT intron-variant
rs1000042179 -- 48,347,935(+) GGAAT(C/T)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKAP1 Gene

Variant ID Type Subtype PubMed ID
dgv5674n54 CNV loss 21841781
dgv5675n54 CNV loss 21841781
esv23897 CNV loss 19812545
esv2658580 CNV deletion 23128226
esv2716012 CNV deletion 23290073
esv2716013 CNV deletion 23290073
esv2761960 CNV gain 21179565
esv3554502 CNV deletion 23714750
esv3582799 CNV loss 25503493
esv3640713 CNV loss 21293372
esv3640715 CNV loss 21293372
nsv1109083 CNV deletion 24896259
nsv469808 CNV loss 16826518
nsv477638 CNV novel sequence insertion 20440878
nsv478236 CNV novel sequence insertion 20440878
nsv575466 CNV loss 21841781
nsv575467 CNV loss 21841781
nsv575469 CNV loss 21841781
nsv575474 CNV loss 21841781
nsv833469 CNV loss 17160897
nsv953921 CNV duplication 24416366

Variation tolerance for SKAP1 Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKAP1 Gene

Disorders for SKAP1 Gene

Relevant External Links for SKAP1

Genetic Association Database (GAD)
SKAP1
Human Genome Epidemiology (HuGE) Navigator
SKAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKAP1

No disorders were found for SKAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKAP1 Gene

Publications for SKAP1 Gene

  1. Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes. (PMID: 9195899) Marie-Cardine A … Schraven B (The Journal of biological chemistry 1997) 2 3 4 22 60
  2. SKAP55 modulates T cell antigen receptor-induced activation of the Ras-Erk-AP1 pathway by binding RasGRP1. (PMID: 17658605) Kosco KA … Mustelin T (Molecular immunology 2008) 3 4 22 60
  3. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. (PMID: 16980616) Kliche S … Schraven B (Molecular and cellular biology 2006) 3 4 22 60
  4. Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. (PMID: 15849195) Huang Y … Wange RL (The Journal of biological chemistry 2005) 3 4 22 60
  5. SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. (PMID: 12171928) Wu L … Shen SH (The Journal of biological chemistry 2002) 3 4 22 60

Products for SKAP1 Gene

Sources for SKAP1 Gene

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