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Aliases for SKAP1 Gene

Aliases for SKAP1 Gene

  • Src Kinase Associated Phosphoprotein 1 2 3
  • SKAP55 3 4 6
  • SCAP1 3 4 6
  • Src Kinase-Associated Phosphoprotein Of 55 KDa 3 4
  • Src Family Associated Phosphoprotein 1 2 3
  • Src Family-Associated Phosphoprotein 1 3 4
  • SKAP-55 3 4
  • Pp55 3 4
  • Epididymis Secretory Sperm Binding Protein Li 81p 3
  • Src Kinase-Associated Phosphoprotein 1 3
  • HEL-S-81p 3

External Ids for SKAP1 Gene

Previous HGNC Symbols for SKAP1 Gene

  • SCAP1

Previous GeneCards Identifiers for SKAP1 Gene

  • GC17M043566
  • GC17M046210
  • GC17M041580

Summaries for SKAP1 Gene

Entrez Gene Summary for SKAP1 Gene

  • This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

GeneCards Summary for SKAP1 Gene

SKAP1 (Src Kinase Associated Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and B cell receptor signaling pathway (KEGG). GO annotations related to this gene include phospholipid binding and protein complex binding. An important paralog of this gene is SKAP2.

UniProtKB/Swiss-Prot for SKAP1 Gene

  • Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Gene Wiki entry for SKAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKAP1 Gene

Genomics for SKAP1 Gene

Regulatory Elements for SKAP1 Gene

Genomic Location for SKAP1 Gene

Start:
48,133,440 bp from pter
End:
48,430,275 bp from pter
Size:
296,836 bases
Orientation:
Minus strand

Genomic View for SKAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKAP1 Gene

Proteins for SKAP1 Gene

  • Protein details for SKAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WV1-SKAP1_HUMAN
    Recommended name:
    Src kinase-associated phosphoprotein 1
    Protein Accession:
    Q86WV1
    Secondary Accessions:
    • D3DTV1
    • O15268

    Protein attributes for SKAP1 Gene

    Size:
    359 amino acids
    Molecular mass:
    41432 Da
    Quaternary structure:
    • Homodimer. Interacts with FYN and PTPRC. Interacts with GRB2 when phosphorylated on Tyr-271. Interacts with FYB, which is required for SKAP2 protein stability. Part of a complex consisting of SKAP1, FYB and CLNK. Interacts with RASGRP1.

    Three dimensional structures from OCA and Proteopedia for SKAP1 Gene

    Alternative splice isoforms for SKAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKAP1 Gene

Proteomics data for SKAP1 Gene at MOPED

Post-translational modifications for SKAP1 Gene

  • Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB. Tyr-232 is dephosphorylated by PTPRC (Probable).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SKAP1 Gene

Domains for SKAP1 Gene

Gene Families for SKAP1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for SKAP1 Gene

Suggested Antigen Peptide Sequences for SKAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WV1

UniProtKB/Swiss-Prot:

SKAP1_HUMAN :
  • Q86WV1
Domain:
  • The SH3 domain interacts with FYB
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the SKAP family.
genes like me logo Genes that share domains with SKAP1: view

Function for SKAP1 Gene

Molecular function for SKAP1 Gene

UniProtKB/Swiss-Prot Function: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

Gene Ontology (GO) - Molecular Function for SKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IC 9195899
GO:0005515 protein binding IPI 16461356
GO:0017124 SH3 domain binding TAS 11909961
GO:0019901 protein kinase binding IPI 9195899
GO:0019903 protein phosphatase binding IPI 11909961
genes like me logo Genes that share ontologies with SKAP1: view
genes like me logo Genes that share phenotypes with SKAP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SKAP1 Gene

Localization for SKAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKAP1 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKAP1 Gene COMPARTMENTS Subcellular localization image for SKAP1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
cytoskeleton 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA 11909961
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with SKAP1: view

Pathways for SKAP1 Gene

genes like me logo Genes that share pathways with SKAP1: view

Pathways by source for SKAP1 Gene

1 BioSystems pathway for SKAP1 Gene
1 KEGG pathway for SKAP1 Gene

Gene Ontology (GO) - Biological Process for SKAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009967 positive regulation of signal transduction IC 9195899
GO:0045893 positive regulation of transcription, DNA-templated IMP 11909961
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 11909961
GO:0050852 T cell receptor signaling pathway IMP 11909961
genes like me logo Genes that share ontologies with SKAP1: view

Compounds for SKAP1 Gene

(1) Novoseek inferred chemical compound relationships for SKAP1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 43 9
genes like me logo Genes that share compounds with SKAP1: view

Transcripts for SKAP1 Gene

Unigene Clusters for SKAP1 Gene

Src kinase associated phosphoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - -
SP2: - - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for SKAP1 Gene

GeneLoc Exon Structure for
SKAP1
ECgene alternative splicing isoforms for
SKAP1

Expression for SKAP1 Gene

mRNA expression in normal human tissues for SKAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SKAP1 Gene

This gene is overexpressed in Whole Blood (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKAP1 Gene

SOURCE GeneReport for Unigene cluster for SKAP1 Gene Hs.316931

mRNA Expression by UniProt/SwissProt for SKAP1 Gene

Q86WV1-SKAP1_HUMAN
Tissue specificity: Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
genes like me logo Genes that share expressions with SKAP1: view

Orthologs for SKAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKAP1 35
  • 99.63 (n)
  • 99.72 (a)
SKAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKAP1 35
  • 91.48 (n)
  • 87.64 (a)
SKAP1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKAP1 35
  • 91.5 (n)
  • 89.08 (a)
SKAP1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Skap1 35
  • 86.49 (n)
  • 82.18 (a)
Skap1 16
Skap1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKAP1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKAP1 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Skap1 35
  • 85.62 (n)
  • 81.43 (a)
chicken
(Gallus gallus)
Aves SKAP1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKAP1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia skap1 35
  • 60.98 (n)
  • 51.8 (a)
Str.9700 35
zebrafish
(Danio rerio)
Actinopterygii skap1 35
  • 58.53 (n)
  • 54.71 (a)
skap1 36
  • 47 (a)
OneToOne
Species with no ortholog for SKAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKAP1 Gene

ENSEMBL:
Gene Tree for SKAP1 (if available)
TreeFam:
Gene Tree for SKAP1 (if available)

Paralogs for SKAP1 Gene

Paralogs for SKAP1 Gene

Selected SIMAP similar genes for SKAP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SKAP1: view

Variants for SKAP1 Gene

Sequence variations from dbSNP and Humsavar for SKAP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs183281 -- 48,171,014(-) CATGA(A/G)ACTGA intron-variant
rs208005 -- 48,162,623(-) ATGGG(C/T)ACCTC intron-variant
rs208006 -- 48,160,305(-) AAATT(A/T)AAAAA intron-variant
rs208007 -- 48,154,153(-) TGTCA(A/G)TTATA intron-variant
rs208008 -- 48,153,476(-) GCAAC(A/G)GAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKAP1 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV Complex 16826518
nsv908576 CNV Gain 21882294
esv2716012 CNV Deletion 23290073
esv2716013 CNV Deletion 23290073
esv2658580 CNV Deletion 23128226
esv23897 CNV Loss 19812545
nsv833469 CNV Loss 17160897
esv268582 CNV Insertion 20981092
esv273577 CNV Insertion 20981092

Relevant External Links for SKAP1 Gene

HapMap Linkage Disequilibrium report
SKAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKAP1 Gene

Disorders for SKAP1 Gene

Relevant External Links for SKAP1

Genetic Association Database (GAD)
SKAP1
Human Genome Epidemiology (HuGE) Navigator
SKAP1
genes like me logo Genes that share disorders with SKAP1: view

No data available for UniProtKB/Swiss-Prot for SKAP1 Gene

Publications for SKAP1 Gene

  1. Molecular cloning of SKAP55, a novel protein that associates with p59fyn in human T-lymphocytes. (PMID: 9195899) Marie-Cardine A. … Schraven B. (J. Biol. Chem. 1997) 2 3 4 23
  2. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PMID: 9671755) Liu J. … Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. (PMID: 9748251) Marie-Cardine A. … Koretzky G.A. (J. Biol. Chem. 1998) 3 4 23
  4. SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation. (PMID: 12171928) Wu L. … Shen S.-H. (J. Biol. Chem. 2002) 3 4 23
  5. Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. (PMID: 15849195) Huang Y. … Wange R.L. (J. Biol. Chem. 2005) 3 4 23

Products for SKAP1 Gene

Sources for SKAP1 Gene

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