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Aliases for SKA3 Gene

Aliases for SKA3 Gene

  • Spindle And Kinetochore Associated Complex Subunit 3 2 3
  • C13orf3 3 4
  • RAMA1 3 4
  • Spindle And Kinetochore-Associated Protein 3 3
  • Chromosome 13 Open Reading Frame 3 2

External Ids for SKA3 Gene

Previous Symbols for SKA3 Gene

  • C13orf3

Summaries for SKA3 Gene

Entrez Gene Summary for SKA3 Gene

  • This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for SKA3 Gene

SKA3 (Spindle And Kinetochore Associated Complex Subunit 3) is a Protein Coding gene. Diseases associated with SKA3 include acute poststreptococcal glomerulonephritis.

UniProtKB/Swiss-Prot for SKA3 Gene

  • Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKA3 Gene

Genomics for SKA3 Gene

Genomic Location for SKA3 Gene

Start:
21,153,595 bp from pter
End:
21,176,602 bp from pter
Size:
23,008 bases
Orientation:
Minus strand

Genomic View for SKA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKA3 Gene

No data available for Regulatory Elements for SKA3 Gene

Proteins for SKA3 Gene

  • Protein details for SKA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX90-SKA3_HUMAN
    Recommended name:
    Spindle and kinetochore-associated protein 3
    Protein Accession:
    Q8IX90
    Secondary Accessions:
    • A2A330
    • A2A331
    • B2RBY2
    • Q5VZV5
    • Q86WR2
    • Q8NBG1
    • Q96D22

    Protein attributes for SKA3 Gene

    Size:
    412 amino acids
    Molecular mass:
    46359 Da
    Quaternary structure:
    • Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1.
    SequenceCaution:
    • Sequence=AAH13418.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG37379.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37379.1; Type=Frameshift; Positions=29; Evidence={ECO:0000305}; Sequence=CAH69950.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAX08294.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SKA3 Gene

    Alternative splice isoforms for SKA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKA3 Gene

Proteomics data for SKA3 Gene at MOPED

Post-translational modifications for SKA3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn316

Other Protein References for SKA3 Gene

No data available for DME Specific Peptides for SKA3 Gene

Domains for SKA3 Gene

Protein Domains for SKA3 Gene

ProtoNet:

UniProtKB/Swiss-Prot:

SKA3_HUMAN
Family:
  • Belongs to the SKA3 family.:
    • Q8IX90
genes like me logo Genes that share domains with SKA3: view

No data available for Gene Families for SKA3 Gene

Function for SKA3 Gene

Molecular function for SKA3 Gene

UniProtKB/Swiss-Prot Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization.

Gene Ontology (GO) - Molecular Function for SKA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19289083
genes like me logo Genes that share ontologies with SKA3: view
genes like me logo Genes that share phenotypes with SKA3: view

miRNA for SKA3 Gene

miRTarBase miRNAs that target SKA3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SKA3 Gene

Localization for SKA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKA3 Gene

Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKA3 Gene COMPARTMENTS Subcellular localization image for SKA3 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
plasma membrane 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SKA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000940 condensed chromosome outer kinetochore IDA 19289083
GO:0005737 cytoplasm IEA --
GO:0005876 spindle microtubule IDA 19289083
genes like me logo Genes that share ontologies with SKA3: view

Pathways for SKA3 Gene

SuperPathways for SKA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SKA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IMP 19289083
GO:0007067 mitotic nuclear division IMP 19289083
GO:0031110 regulation of microtubule polymerization or depolymerization IDA 19289083
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SKA3: view

No data available for Pathways by source for SKA3 Gene

Transcripts for SKA3 Gene

Unigene Clusters for SKA3 Gene

Spindle and kinetochore associated complex subunit 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: -
SP2: - -
SP3: - - - - - - -
SP4:

Relevant External Links for SKA3 Gene

GeneLoc Exon Structure for
SKA3
ECgene alternative splicing isoforms for
SKA3

Expression for SKA3 Gene

mRNA expression in normal human tissues for SKA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SKA3 Gene

This gene is overexpressed in Testis (6.7) and Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKA3 Gene

SOURCE GeneReport for Unigene cluster for SKA3 Gene Hs.88523

genes like me logo Genes that share expressions with SKA3: view

Orthologs for SKA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKA3 36
  • 99.55 (n)
  • 99.2 (a)
SKA3 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKA3 36
  • 84.92 (n)
  • 76.75 (a)
SKA3 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKA3 36
  • 85.76 (n)
  • 77.67 (a)
SKA3 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ska3 36
  • 76.01 (n)
  • 64.02 (a)
Ska3 16
Ska3 37
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKA3 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKA3 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ska3 36
  • 74.88 (n)
  • 63.17 (a)
chicken
(Gallus gallus)
Aves SKA3 36
  • 55.01 (n)
  • 42.82 (a)
SKA3 37
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ska3 36
  • 50.57 (n)
  • 39.25 (a)
zebrafish
(Danio rerio)
Actinopterygii ska3 37
  • 20 (a)
OneToOne
Species with no ortholog for SKA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKA3 Gene

ENSEMBL:
Gene Tree for SKA3 (if available)
TreeFam:
Gene Tree for SKA3 (if available)

Paralogs for SKA3 Gene

No data available for Paralogs for SKA3 Gene

Variants for SKA3 Gene

Sequence variations from dbSNP and Humsavar for SKA3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs598000 -- 21,178,015(-) AACAG(C/T)TCTGA upstream-variant-2KB
rs913206 -- 21,153,428(-) gaagg(C/T)gtagt downstream-variant-500B
rs1327178 -- 21,154,344(-) CACGG(A/G)AGCCT utr-variant-3-prime
rs1327179 -- 21,154,181(-) CATAC(C/T)GTGGA utr-variant-3-prime
rs1409833 -- 21,154,548(-) GGTTG(A/T)GAGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SKA3 Gene

Variant ID Type Subtype PubMed ID
nsv899878 CNV Gain 21882294
esv28665 CNV Gain 19812545
dgv315n67 CNV Gain 20364138
esv32897 CNV Loss 17666407
nsv512307 CNV Loss 21212237
esv2747075 CNV Deletion 23290073
dgv241e201 CNV Deletion 23290073
dgv242e201 CNV Deletion 23290073
esv1003302 CNV Deletion 20482838
esv2175517 CNV Deletion 18987734
esv2747086 CNV Deletion 23290073
esv1007120 CNV Deletion 20482838
esv1249925 CNV Deletion 17803354
esv8341 CNV Loss 19470904
dgv243e201 CNV Deletion 23290073
dgv244e201 CNV Deletion 23290073
dgv245e201 CNV Deletion 23290073
esv997322 CNV Loss 20482838
nsv826585 CNV Gain 20364138
dgv316n67 CNV Gain 20364138
esv2747098 CNV Deletion 23290073
esv33455 CNV Loss 17666407
nsv64608 CNV Loss 16902084
esv2747099 CNV Deletion 23290073

Relevant External Links for SKA3 Gene

HapMap Linkage Disequilibrium report
SKA3

Disorders for SKA3 Gene

(1) University of Copenhagen DISEASES for SKA3 Gene

genes like me logo Genes that share disorders with SKA3: view

No data available for UniProtKB/Swiss-Prot for SKA3 Gene

Publications for SKA3 Gene

  1. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. (PMID: 19289083) Welburn J.P.I. … Cheeseman I.M. (Dev. Cell 2009) 2 3 4
  2. Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. (PMID: 19360002) Gaitanos T.N. … Nigg E.A. (EMBO J. 2009) 2 3 4
  3. Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. (PMID: 19387489) Theis M. … Buchholz F. (EMBO J. 2009) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4

Products for SKA3 Gene

  • Addgene plasmids for SKA3

Sources for SKA3 Gene

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