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Aliases for SKA2 Gene

Aliases for SKA2 Gene

  • Spindle And Kinetochore Associated Complex Subunit 2 2 3 5
  • Family With Sequence Similarity 33, Member A 2 3
  • FAM33A 3 4
  • Spindle And KT (Kinetochore) Associated 2 3
  • Protein FAM33A 4

External Ids for SKA2 Gene

Previous HGNC Symbols for SKA2 Gene

  • FAM33A

Previous GeneCards Identifiers for SKA2 Gene

  • GC17M054544
  • GC17M057188
  • GC17M052547

Summaries for SKA2 Gene

GeneCards Summary for SKA2 Gene

SKA2 (Spindle And Kinetochore Associated Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for SKA2 Gene

  • Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKA2 Gene

Genomics for SKA2 Gene

Regulatory Elements for SKA2 Gene

Promoters for SKA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SKA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SKA2 Gene

Chromosome:
17
Start:
59,109,947 bp from pter
End:
59,155,439 bp from pter
Size:
45,493 bases
Orientation:
Minus strand

Genomic View for SKA2 Gene

Genes around SKA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKA2 Gene

Proteins for SKA2 Gene

  • Protein details for SKA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVK7-SKA2_HUMAN
    Recommended name:
    Spindle and kinetochore-associated protein 2
    Protein Accession:
    Q8WVK7
    Secondary Accessions:
    • A6NIL3
    • B3KPL3
    • E9PCB8

    Protein attributes for SKA2 Gene

    Size:
    121 amino acids
    Molecular mass:
    14188 Da
    Quaternary structure:
    • Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1. May interact with NR3C1; the relevance of such interaction remains unclear in vivo.

    Three dimensional structures from OCA and Proteopedia for SKA2 Gene

    Alternative splice isoforms for SKA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKA2 Gene

Proteomics data for SKA2 Gene at MOPED

Post-translational modifications for SKA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SKA2 Gene

Domains & Families for SKA2 Gene

Protein Domains for SKA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SKA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WVK7

UniProtKB/Swiss-Prot:

SKA2_HUMAN :
  • Belongs to the SKA2 family.
Family:
  • Belongs to the SKA2 family.
genes like me logo Genes that share domains with SKA2: view

No data available for Gene Families for SKA2 Gene

Function for SKA2 Gene

Molecular function for SKA2 Gene

UniProtKB/Swiss-Prot Function:
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:17093495, PubMed:19289083). In the complex, it is required for SKA1 localization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020).
genes like me logo Genes that share phenotypes with SKA2: view

Animal Models for SKA2 Gene

MGI Knock Outs for SKA2:
  • Ska2 tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKA2 Gene

Localization for SKA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKA2 Gene

Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. {ECO:0000269 PubMed:17093495, ECO:0000269 PubMed:19289083}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKA2 Gene COMPARTMENTS Subcellular localization image for SKA2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for SKA2 Gene

Pathways & Interactions for SKA2 Gene

genes like me logo Genes that share pathways with SKA2: view

Pathways by source for SKA2 Gene

Gene Ontology (GO) - Biological Process for SKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA,IMP 19289083
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA,IMP 19289083
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SKA2: view

No data available for SIGNOR curated interactions for SKA2 Gene

Drugs & Compounds for SKA2 Gene

No Compound Related Data Available

Transcripts for SKA2 Gene

Unigene Clusters for SKA2 Gene

Spindle and kinetochore associated complex subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -
SP9: - - - -

Relevant External Links for SKA2 Gene

GeneLoc Exon Structure for
SKA2
ECgene alternative splicing isoforms for
SKA2

Expression for SKA2 Gene

mRNA expression in normal human tissues for SKA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SKA2 Gene

This gene is overexpressed in Adipocyte (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKA2 Gene



SOURCE GeneReport for Unigene cluster for SKA2 Gene Hs.463607

genes like me logo Genes that share expression patterns with SKA2: view

Protein tissue co-expression partners for SKA2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SKA2 Gene

Orthologs for SKA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKA2 35
  • 98.9 (n)
  • 97.52 (a)
SKA2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKA2 36
  • 83 (a)
OneToOne
SKA2 35
  • 89.53 (n)
  • 81.82 (a)
dog
(Canis familiaris)
Mammalia SKA2 35
  • 91.46 (n)
  • 85.12 (a)
SKA2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ska2 16
Ska2 36
  • 78 (a)
OneToOne
Ska2 35
  • 86.11 (n)
  • 77.5 (a)
oppossum
(Monodelphis domestica)
Mammalia SKA2 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKA2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691962 35
  • 83.47 (n)
  • 71.9 (a)
chicken
(Gallus gallus)
Aves SKA2 35
  • 65.53 (n)
  • 52.99 (a)
SKA2 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKA2 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ska2 35
  • 60.87 (n)
  • 46.96 (a)
zebrafish
(Danio rerio)
Actinopterygii SKA2 36
  • 20 (a)
OneToOne
im:7140390 35
  • 59.12 (n)
  • 43.4 (a)
Species with no ortholog for SKA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKA2 Gene

ENSEMBL:
Gene Tree for SKA2 (if available)
TreeFam:
Gene Tree for SKA2 (if available)

Paralogs for SKA2 Gene

(3) SIMAP similar genes for SKA2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SKA2 Gene

genes like me logo Genes that share paralogs with SKA2: view

No data available for Paralogs for SKA2 Gene

Variants for SKA2 Gene

Sequence variations from dbSNP and Humsavar for SKA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs6503896 -- 59,116,164(+) tcagg(A/G)gttcg intron-variant
rs7214098 -- 59,127,271(+) ggaca(C/T)gtgcc intron-variant
rs8067682 -- 59,142,030(+) gttca(A/G)agctg intron-variant
rs7222087 -- 59,144,258(+) aaaaa(A/T)gacaa intron-variant
rs9889557 -- 59,125,074(+) gttca(A/G)gcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKA2 Gene

Variant ID Type Subtype PubMed ID
dgv3236n71 CNV Loss 21882294
nsv908644 CNV Loss 21882294
nsv908646 CNV Loss 21882294
nsv833499 CNV Loss 17160897
dgv995e1 CNV Complex 17122850
dgv3237n71 CNV Loss 21882294
esv990139 CNV Deletion 20482838
esv28194 CNV Loss 19812545

Variation tolerance for SKA2 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SKA2 Gene

HapMap Linkage Disequilibrium report
SKA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKA2 Gene

Disorders for SKA2 Gene

Relevant External Links for SKA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKA2

No disorders were found for SKA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKA2 Gene

Publications for SKA2 Gene

  1. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. (PMID: 19289083) Welburn J.P.I. … Cheeseman I.M. (Dev. Cell 2009) 2 3 4 67
  2. Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. (PMID: 18583474) Rice L. … Ray D.W. (J. Endocrinol. 2008) 2 3
  3. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. (PMID: 17093495) Hanisch A. … Nigg E.A. (EMBO J. 2006) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors. (PMID: 25073599) Guintivano J. … Kaminsky Z.A. (Am J Psychiatry 2014) 3

Products for SKA2 Gene

Sources for SKA2 Gene

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