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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SKA2 Gene

protein-coding GIFtS: 52
GCID: GC17M057188

spindle and kinetochore associated complex subunit 2

(Previous names: family with sequence similarity 33, member A )
(Previous symbol: FAM33A)

Explore 5 diseases affiliated with
SKA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Spindle And Kinetochore Associated Complex Subunit 2¹ ²		Spindle And Kinetochore-Associated Protein 2²
FAM33A¹ ² ³		Spindle And KT (Kinetochore) Associated 2²
Family With Sequence Similarity 33, Member A¹ ²		Protein FAM33A³
FLJ12758¹

External Ids:	HGNC: 28006¹	Entrez Gene: 348235²	Ensembl: ENSG00000182628⁷	UniProtKB: Q8WVK7³

Export aliases for SKA2 gene to outside databases

Previous GC identifers: GC17M054544 GC17M052547

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7

Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential

for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar

attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct

component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies.

The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled

manner. In the complex, it is required for SKA1 localization

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SKA2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SKA2 promoter sequence

Search SABiosciences Chromatin IP Primers for SKA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SKA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.2

SKA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKA2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M057188: view genomic region (about GC identifiers)

Start:	57,187,308 bp from pter	End:	57,232,800 bp from pter
Size:	45,493 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7 (See protein sequence)

Recommended Name: Spindle and kinetochore-associated protein 2

Size: 121 amino acids; 14188 Da

Subunit: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer

interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting

with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric

assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1.

May interact with NR3C1; the relevance of such interaction remains unclear in vivo

Subcellular location: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the

outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the

mitotic spindle and kinetochore-associated proteins

1 PDB 3D structure from and Proteopedia for SKA2:

4AJ5 (3D)

Secondary accessions: A6NIL3 B3KPL3

Explore the universe of human proteins at neXtProt for SKA2: NX_Q8WVK7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WVK7

SKA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001094065.1 NP_872426.1

ENSEMBL proteins:

ENSP00000333433 ENSP00000462197 ENSP00000462918 ENSP00000464558 ENSP00000462220

ENSP00000411231 ENSP00000462574 ENSP00000463167 ENSP00000463315

Reactome Protein details: Q8WVK7
Human Recombinant Protein Products:

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	Uscn Proteins for SKA2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000940	condensed chromosome outer kinetochore	IDA	17093495
GO:0005829	cytosol	TAS	--
GO:0005876	spindle microtubule	IDA	19289083

SKA2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SKA2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SKA2 for domains About GeneDecksing

1 InterPro domain/family:

IPR026762 Ska2

Graphical View of Domain Structure for InterPro Entry Q8WVK7

ProtoNet protein and cluster: Q8WVK7

UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7

Similarity: Belongs to the SKA2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7

Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential

for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar

attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct

component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies.

The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled

manner. In the complex, it is required for SKA1 localization

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SKA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SKA2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SKA2 (see all 9):
		hsa-miR-1226 hsa-miR-513a-3p hsa-miR-26b* hsa-miR-3617 hsa-miR-570 hsa-miR-3943 hsa-miR-641 hsa-miR-501-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SKA2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SKA2 (see all 4) OriGene shRNA RFP: SKA2 Browse OriGene siRNA
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKA2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19289083
GO:0008017	microtubule binding	IDA	19289083

SKA2 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for SKA2:

Cell cycle / mitosis defect

Increased gamma-H2AX phosphory

Increased number of cells in m

Metaphase cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 Reactome Pathways for SKA2 (see all 10)

	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Mitotic Anaphase
	Cell Cycle

SKA2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SKA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/50 Interacting proteins for SKA2 (Q8WVK7^{2, 3} ENSP00000333433⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKA1	Q96BD8²^,³, ENSP00000285116⁴	MINT-3391334 MINT-7277219 MINT-3391284 MINT-3391398 MINT-7277243 MINT-7277201 MINT-3391311 MINT-7277189 MINT-4051212 MINT-3391357 MINT-3391375 I2D: score=2 STRING: ENSP00000285116
SKA3	Q8IX90², ENSP00000319417⁴	MINT-7277243 MINT-7277189 MINT-7277201 MINT-7277219 STRING: ENSP00000319417
PPP2R2B	Q00005³, ENSP00000336591⁴	I2D: score=2 STRING: ENSP00000336591
SEPT1	Q8WYJ6³	I2D: score=1
BIRC5	ENSP00000301633⁴	STRING: ENSP00000301633

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000090	mitotic anaphase	IMP	17093495
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007059	chromosome segregation	IMP	19289083

SKA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SKA2
Search CenterWatch for drugs/clinical trials and news about SKA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SKA2 gene (2 alternative transcripts):

NM_001100595.1 NM_182620.3

Unigene Cluster for SKA2:

Spindle and kinetochore associated complex subunit 2

Hs.463607 [show with all ESTs]

Unigene Representative Sequence: NM_182620

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000330137(uc002ixd.2 uc010dde.1 uc002ixe.2) ENST00000580541

ENST00000578105 ENST00000578519 ENST00000583927 ENST00000581068 ENST00000437036

ENST00000583380 ENST00000583976 ENST00000584089

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SKA2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SKA2 (see all 9):
		hsa-miR-1226 hsa-miR-513a-3p hsa-miR-26b* hsa-miR-3617 hsa-miR-570 hsa-miR-3943 hsa-miR-641 hsa-miR-501-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SKA2 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SKA2

Additional cDNA sequence:

AK022820.1 AK056473.1 BC017873.1 BC106003.1 FJ648812.1

20 DOTS entries:

DT.442164 DT.91748900 DT.120930624 DT.120930321 DT.120930477 DT.311923 DT.100789865 DT.100789866

DT.91748898 DT.95375423 DT.100831346 DT.95375425 DT.120930659 DT.100760004 DT.100837243 DT.101970413

DT.121197555 DT.75169062 DT.91748899 DT.97844312

24/174 AceView cDNA sequences (see all 174):

R15444 BU181827 BE048371 AA856661 AI671479 BX395238 BP871774 N56070

NM_182620 CA420007 BG395794 CR615257 BG260898 AA101461 AI436329 AA362052

BX332880 AI091258 AI249716 BU621322 BU507533 AA100371 BM015713 BM764556

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SKA2 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	·	5g
SP1:							-								-
SP2:							-				-				-
SP3:											-				-
SP4:							-				-
SP5:							-				-		-		-

ECgene alternative splicing isoforms for SKA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SKA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGAATAC

About this image

SKA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SKA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SKA2

SOURCE GeneReport for Unigene cluster: Hs.463607

SABiosciences Custom PCR Arrays for SKA2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SKA2 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SKA2¹	spindle and kinetochore associated complex subunit more	65.52(n) 53.45(a)		417629 XM_415873.3 XP_415873.1
lizard (Anolis carolinensis)	Reptilia	--	--	38(a)	1 → many	GL343684.1(333452-336295)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX743148.1²	--	76.87(n)		BX743148.1
zebrafish (Danio rerio)	Actinopterygii	im:7140390¹	im:7140390	58.95(n) 42.59(a)		449942 NM_001199675.1 NP_001186604.1

ENSEMBL Gene Tree for SKA2 (if available)
TreeFam Gene Tree for SKA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SKA2 gene

SKA2P1²

4 SIMAP similar genes for SKA2 using alignment to 9 protein entries: SKA2_HUMAN (see all proteins):

FAM33A HOOK2 APOPT1 ZNF410

SKA2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SKA2
PGOHUM00000239600

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200703829^1,2		--	57186824(+)	`CTGTT-/TTGTTGTT`	2	--	int¹		0	--	--	--	--
rs150000843^1,2		--	57186830(+)	`TGTTG-/TTTTTT`	2	--	int¹		0	--	--	--	--
rs61092888^1,2	C	--	57186833(+)	`TTTTT-/TGTTTT`	2	--	int¹		0	--	--	--	--
rs146420555^1,2		--	57186919(+)	`GCGCAA/CTCTCA`	2	--	int¹		0	--	--	--	--
rs182236285^1,2		--	57186979(+)	`CCTCCC/GGAGTA`	2	--	int¹		0	--	--	--	--
rs186356056^1,2		--	57186980(+)	`CTCCCA/GAGTAG`	2	--	int¹		0	--	--	--	--
rs190709101^1,2		--	57186996(+)	`ACTACA/GGGCAC`	2	--	int¹		0	--	--	--	--
rs182874831^1,2		--	57187482(+)	`AATACA/GGATCT`	2	--	ut3¹		0	--	--	--	--
rs149114699^1,2		--	57187508(+)	`AGTTAC/TATTTA`	2	--	ut3¹		0	--	--	--	--
rs7208505^1,2	C,F,A,H,	--	57187729(+)	`CTACCA/GTTTTT`	2	--	ut3¹		33		NS EA NA WA CSA	2924

HapMap Linkage Disequilibrium report for SKA2 (57187308 - 57232800 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SKA2
1 CNV: 4043
1 Indel: 67233

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SKA2

DNA2.0 Custom Variant and Variant Library Synthesis for SKA2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SKA2 for disorders About GeneDecksing

5 diseases for SKA2: About MalaCards

acute poststreptococcal glomerulonephritis rheumatic fever impetigo glomerulonephritis

acne

3 diseases from the University of Copenhagen DISEASES database for SKA2:

Acute poststreptococcal glomerulonephritis Rheumatic fever Impetigo

Export disorders for SKA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SKA2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with SKA2)

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The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. (PubMed id 19289083)^{1, 2, 3} Welburn J.P.I.... Cheeseman I.M. (2009)
Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. (PubMed id 18583474)^{1, 2, 3} Rice L....Ray D.W. (2008)
Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. (PubMed id 17093495)^{1, 2, 3} Hanisch A.... Nigg E.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. (PubMed id 22371557)¹ Chan Y.W....Santamaria A. (2012)
Structural and functional organization of the Ska comp lex, a key component of the kinetochore-microtubule interface. (PubMed id 22483620)¹ Jeyaprakash A.A....Conti E. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Intronic miR-301 feedback regulates its host gene, sk a2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways. (PubMed id 20470754)¹ Cao G....Shao N. (2010)
Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)² Oppermann F.S.... Daub H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 348235	HGNC: 28006	AceView: FAM33A	Ensembl:ENSG00000182628	euGenes: HUgn348235
ECgene: SKA2	H-InvDB: SKA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SKA2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SKA2 gene
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Patent Information for SKA2 gene:
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spindle and kinetochore associated complex subunit 2

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SKA2 Gene

spindle and kinetochore associated complex subunit 2

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