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Aliases for SKA2 Gene

Aliases for SKA2 Gene

  • Spindle And Kinetochore Associated Complex Subunit 2 2 3
  • Family With Sequence Similarity 33, Member A 2 3
  • FAM33A 3 4
  • Spindle And Kinetochore-Associated Protein 2 3
  • Spindle And KT (Kinetochore) Associated 2 3
  • Protein FAM33A 4

External Ids for SKA2 Gene

Previous HGNC Symbols for SKA2 Gene

  • FAM33A

Previous GeneCards Identifiers for SKA2 Gene

  • GC17M054544
  • GC17M057188
  • GC17M052547

Summaries for SKA2 Gene

GeneCards Summary for SKA2 Gene

SKA2 (Spindle And Kinetochore Associated Complex Subunit 2) is a Protein Coding gene. Diseases associated with SKA2 include impetigo and acute poststreptococcal glomerulonephritis. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for SKA2 Gene

  • Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKA2 Gene

Genomics for SKA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SKA2 Gene

Start:
59,109,947 bp from pter
End:
59,155,439 bp from pter
Size:
45,493 bases
Orientation:
Minus strand

Genomic View for SKA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SKA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKA2 Gene

No data available for Regulatory Elements for SKA2 Gene

Proteins for SKA2 Gene

  • Protein details for SKA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVK7-SKA2_HUMAN
    Recommended name:
    Spindle and kinetochore-associated protein 2
    Protein Accession:
    Q8WVK7
    Secondary Accessions:
    • A6NIL3
    • B3KPL3
    • E9PCB8

    Protein attributes for SKA2 Gene

    Size:
    121 amino acids
    Molecular mass:
    14188 Da
    Quaternary structure:
    • Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much lower affinity than SKA1. May interact with NR3C1; the relevance of such interaction remains unclear in vivo.

    Three dimensional structures from OCA and Proteopedia for SKA2 Gene

    Alternative splice isoforms for SKA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKA2 Gene

Proteomics data for SKA2 Gene at MOPED

Post-translational modifications for SKA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKA2 Gene

No data available for DME Specific Peptides for SKA2 Gene

Domains for SKA2 Gene

Protein Domains for SKA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SKA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVK7

UniProtKB/Swiss-Prot:

SKA2_HUMAN :
  • Q8WVK7
Family:
  • Belongs to the SKA2 family.
genes like me logo Genes that share domains with SKA2: view

No data available for Gene Families for SKA2 Gene

Function for SKA2 Gene

Molecular function for SKA2 Gene

UniProtKB/Swiss-Prot Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it is required for SKA1 localization.

Gene Ontology (GO) - Molecular Function for SKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17093495
GO:0008017 microtubule binding IDA 19289083
genes like me logo Genes that share ontologies with SKA2: view
genes like me logo Genes that share phenotypes with SKA2: view

Animal Model Products

CRISPR Products

miRNA for SKA2 Gene

miRTarBase miRNAs that target SKA2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SKA2 Gene

Localization for SKA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKA2 Gene

Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKA2 Gene COMPARTMENTS Subcellular localization image for SKA2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000940 condensed chromosome outer kinetochore IDA 17093495
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005876 spindle microtubule IDA 17093495
genes like me logo Genes that share ontologies with SKA2: view

Pathways for SKA2 Gene

genes like me logo Genes that share pathways with SKA2: view

Pathways by source for SKA2 Gene

Gene Ontology (GO) - Biological Process for SKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007059 chromosome segregation IMP 19289083
GO:0007067 mitotic nuclear division IMP 19289083
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0031110 regulation of microtubule polymerization or depolymerization IDA 19289083
genes like me logo Genes that share ontologies with SKA2: view

Transcripts for SKA2 Gene

Unigene Clusters for SKA2 Gene

Spindle and kinetochore associated complex subunit 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SKA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -
SP9: - - - -

Relevant External Links for SKA2 Gene

GeneLoc Exon Structure for
SKA2
ECgene alternative splicing isoforms for
SKA2

Expression for SKA2 Gene

mRNA expression in normal human tissues for SKA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKA2 Gene

SOURCE GeneReport for Unigene cluster for SKA2 Gene Hs.463607

genes like me logo Genes that share expressions with SKA2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SKA2 Gene

Orthologs for SKA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKA2 35
  • 98.9 (n)
  • 97.52 (a)
SKA2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKA2 35
  • 89.53 (n)
  • 81.82 (a)
SKA2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKA2 35
  • 91.46 (n)
  • 85.12 (a)
SKA2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ska2 35
  • 86.11 (n)
  • 77.5 (a)
Ska2 16
Ska2 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKA2 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKA2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691962 35
  • 83.47 (n)
  • 71.9 (a)
chicken
(Gallus gallus)
Aves SKA2 35
  • 65.53 (n)
  • 52.99 (a)
SKA2 36
  • 27 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKA2 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ska2 35
  • 60.87 (n)
  • 46.96 (a)
zebrafish
(Danio rerio)
Actinopterygii im:7140390 35
  • 59.12 (n)
  • 43.4 (a)
SKA2 36
  • 20 (a)
OneToOne
Species with no ortholog for SKA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKA2 Gene

ENSEMBL:
Gene Tree for SKA2 (if available)
TreeFam:
Gene Tree for SKA2 (if available)

Paralogs for SKA2 Gene

Selected SIMAP similar genes for SKA2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for SKA2 Gene

genes like me logo Genes that share paralogs with SKA2: view

No data available for Paralogs for SKA2 Gene

Variants for SKA2 Gene

Sequence variations from dbSNP and Humsavar for SKA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1135591 -- 59,134,608(-) tgcca(C/T)tgcac intron-variant
rs1871751 -- 59,113,007(-) tgaga(C/T)gggag intron-variant
rs2333445 -- 59,124,356(+) GAGCC(C/G)AGGAG intron-variant
rs6416934 -- 59,147,135(+) cctgg(A/G)caaca intron-variant
rs6503896 -- 59,116,164(+) tcagg(A/G)gttcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SKA2 Gene

Variant ID Type Subtype PubMed ID
dgv3236n71 CNV Loss 21882294
nsv908644 CNV Loss 21882294
nsv908646 CNV Loss 21882294
nsv833499 CNV Loss 17160897
dgv995e1 CNV Complex 17122850
dgv3237n71 CNV Loss 21882294
esv990139 CNV Deletion 20482838
esv28194 CNV Loss 19812545

Relevant External Links for SKA2 Gene

HapMap Linkage Disequilibrium report
SKA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKA2 Gene

Disorders for SKA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SKA2 Gene including...

Search for SKA2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for SKA2 Gene

genes like me logo Genes that share disorders with SKA2: view

No data available for UniProtKB/Swiss-Prot for SKA2 Gene

Publications for SKA2 Gene

  1. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. (PMID: 19289083) Welburn J.P.I. … Cheeseman I.M. (Dev. Cell 2009) 2 3 4
  2. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. (PMID: 17093495) Hanisch A. … Nigg E.A. (EMBO J. 2006) 2 3 4
  3. Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. (PMID: 18583474) Rice L. … Ray D.W. (J. Endocrinol. 2008) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SKA2 Gene

  • Addgene plasmids for SKA2

Sources for SKA2 Gene

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