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SKA2 Gene

protein-coding   GIFtS: 52
GCID: GC17M057188

Spindle And Kinetochore Associated Complex Subunit 2

(Previous names: family with sequence similarity 33, member A)
(Previous symbol: FAM33A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spindle And Kinetochore Associated Complex Subunit 21 2
FAM33A1 2 3
Family With Sequence Similarity 33, Member A1 2
Spindle And Kinetochore-Associated Protein 22
Spindle And KT (Kinetochore) Associated 22
Protein FAM33A3

External Ids:    HGNC: 280061   Entrez Gene: 3482352   Ensembl: ENSG000001826287   UniProtKB: Q8WVK73   

Export aliases for SKA2 gene to outside databases

Previous GC identifers: GC17M054544 GC17M052547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SKA2 Gene:
SKA2 (spindle and kinetochore associated complex subunit 2) is a protein-coding gene. Diseases associated with SKA2 include impetigo, and acute poststreptococcal glomerulonephritis. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7
Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is
essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes
undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1
complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules
as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in
a depolymerization-coupled manner. In the complex, it is required for SKA1 localization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SKA2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSKA2 promoter sequence
   Search Chromatin IP Primers for SKA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

SKA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKA2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M057188:  view genomic region     (about GC identifiers)

Start:
57,187,308 bp from pter      End:
57,232,800 bp from pter
Size:
45,493 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7 (See protein sequence)
Recommended Name: Spindle and kinetochore-associated protein 2  
Size: 121 amino acids; 14188 Da
Subunit: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA1; the
heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each
heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules
and forms oligomeric assemblies. Interacts directly with SKA1. Binds directly to microtubules; but with a much
lower affinity than SKA1. May interact with NR3C1; the relevance of such interaction remains unclear in vivo
1 PDB 3D structure from and Proteopedia for SKA2:
4AJ5 (3D)    
Secondary accessions: A6NIL3 B3KPL3 E9PCB8
Alternative splicing: 2 isoforms:  Q8WVK7-1   Q8WVK7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKA2: NX_Q8WVK7

Explore proteomics data for SKA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SKA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001094065.1  NP_872426.1  

    ENSEMBL proteins: 
     ENSP00000333433   ENSP00000462197   ENSP00000462918   ENSP00000464558   ENSP00000462220  
     ENSP00000411231   ENSP00000462574   ENSP00000463167   ENSP00000463315  
    Reactome Protein details: Q8WVK7

    SKA2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026762 Ska2

    Graphical View of Domain Structure for InterPro Entry Q8WVK7

    ProtoNet protein and cluster: Q8WVK7

    UniProtKB/Swiss-Prot: SKA2_HUMAN, Q8WVK7
    Similarity: Belongs to the SKA2 family


    SKA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKA2_HUMAN, Q8WVK7
    Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is
    essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes
    undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1
    complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules
    as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in
    a depolymerization-coupled manner. In the complex, it is required for SKA1 localization

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17093495
    GO:0008017microtubule binding IDA19289083
         
    SKA2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for SKA2:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory  Increased number of cells in m  Metaphase cells 

         1 MGI phenotypic allele for Ska2 (no phenotypes)

    SKA2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKA2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SKA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SKA2

    miRNA
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    miRTarBase miRNAs that target SKA2:
    hsa-mir-375 (MIRT019891), hsa-let-7e-5p (MIRT051441)

    Block miRNA regulation of human, mouse, rat SKA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SKA2 (see all 9):
    hsa-miR-1226 hsa-miR-513a-3p hsa-miR-26b* hsa-miR-3617 hsa-miR-570 hsa-miR-3943 hsa-miR-641 hsa-miR-501-5p
    SwitchGear 3'UTR luciferase reporter plasmidSKA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SKA2

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    GenScript: all cDNA clones in your preferred vector (see all 2): SKA2 (NM_182620)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SKA2_HUMAN, Q8WVK7: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the
    outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both
    the mitotic spindle and kinetochore-associated proteins
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000940condensed chromosome outer kinetochore IDA17093495
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005876spindle microtubule IDA17093495

    SKA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SKA2
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    SKA2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SKA2
    Interactions:

        Search GeneGlobe Interaction Network for SKA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SKA2 (Q8WVK71, 2, 3 ENSP000003334334) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKA1Q96BD81, 2, 3, ENSP000002851164EBI-1773994,EBI-741854 MINT-3391334 MINT-7277219 MINT-3391284 MINT-3391398 MINT-7277243 MINT-7277201 MINT-3391311 MINT-7277189 MINT-4051212 MINT-3391357 MINT-3391375 I2D: score=2 STRING: ENSP00000285116
    SKA3Q8IX902, ENSP000003194174MINT-7277243 MINT-7277189 MINT-7277201 MINT-7277219 STRING: ENSP00000319417
    PPP2R2BQ000053, ENSP000003365914I2D: score=2 STRING: ENSP00000336591
    SEPT1Q8WYJ63I2D: score=1 
    BIRC5ENSP000003016334STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IMP19289083
    GO:0007067mitosis IMP19289083
    GO:0031110regulation of microtubule polymerization or depolymerization IDA19289083
    GO:0051301cell division IMP17093495

    SKA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SKA2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SKA2 gene (2 alternative transcripts): 
    NM_001100595.1  NM_182620.3  

    Unigene Cluster for SKA2:

    Spindle and kinetochore associated complex subunit 2
    Hs.463607  [show with all ESTs]
    Unigene Representative Sequence: NM_182620
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330137(uc002ixd.2 uc010dde.1 uc002ixe.2) ENST00000580541
    ENST00000578105 ENST00000578519 ENST00000583927 ENST00000581068 ENST00000437036
    ENST00000583380 ENST00000583976 ENST00000584089
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SKA2 (see all 9):
    hsa-miR-1226 hsa-miR-513a-3p hsa-miR-26b* hsa-miR-3617 hsa-miR-570 hsa-miR-3943 hsa-miR-641 hsa-miR-501-5p
    SwitchGear 3'UTR luciferase reporter plasmidSKA2 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for SKA2
    OriGene qSTAR qPCR primer pairs in human, mouse for SKA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SKA2
      QuantiTect SYBR Green Assays in human, mouse, rat SKA2
      QuantiFast Probe-based Assays in human, mouse, rat SKA2

    Additional mRNA sequence: 

    AK022820.1 AK056473.1 BC017873.1 BC106003.1 FJ648812.1 

    20 DOTS entries:

    DT.442164  DT.91748900  DT.120930624  DT.120930321  DT.120930477  DT.311923  DT.100789865  DT.100789866 
    DT.91748898  DT.95375423  DT.100831346  DT.95375425  DT.120930659  DT.100760004  DT.100837243  DT.101970413 
    DT.121197555  DT.75169062  DT.91748899  DT.97844312 

    Selected AceView cDNA sequences (see all 174):

    BU176723 AW572165 AI249716 AA100470 BE048371 AA884219 BU679751 BX362986 
    CA420007 BG395794 BQ013026 AA100371 BM764556 BM015713 CR605288 AA324028 
    BX112680 AW102750 BX445888 BQ439086 AI494042 AI375095 AI091258 BU181827 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SKA2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
    SP1:                    -                       -                                             
    SP2:                    -           -           -                                             
    SP3:                                -           -                                             
    SP4:                    -           -                                                         
    SP5:                    -           -     -     -                                             


    ECgene alternative splicing isoforms for SKA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SKA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGAATAC
    SKA2 Expression
    About this image


    SKA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
    SKA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463607
        Custom PCR Arrays for SKA2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SKA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SKA2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ska21 , 5 family with sequence similarity 33, member A5
    spindle and kinetochore associated complex subunit more1
    86.11(n)1
    77.5(a)1
      11 (51.91 cM)5
    661401  NM_025377.31  NP_079653.11 
     871092345 
    chicken
    (Gallus gallus)
    Aves SKA21 spindle and kinetochore associated complex subunit more 65.53(n)
    52.99(a)
      417629  XM_415873.4  XP_415873.1 
    lizard
    (Anolis carolinensis)
    Reptilia SKA26
    spindle and kinetochore associated complex subunit...
    39(a)
    1 ↔ 1
    GL343684.1(333452-336295)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX743148.12   -- 76.87(n)    BX743148.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71403901 im:7140390 59.12(n)
    43.4(a)
      449942  NM_001199675.1  NP_001186604.1 


    ENSEMBL Gene Tree for SKA2 (if available)
    TreeFam Gene Tree for SKA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SKA2 gene
    3 SIMAP similar genes for SKA2 using alignment to 8 protein entries:     SKA2_HUMAN (see all proteins):
    FAM33A    HOOK2    APOPT1

    SKA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SKA2
    PGOHUM00000239600


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SKA2 (see all 634)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007038291,2
    --57186824(+) CTGTT-/TTGTTGTT 2 -- int10--------
    rs610928881,2
    C--57186832(+) TTTTT-/TGTTTT 2 -- int10--------
    rs1464205551,2
    C--57186919(+) GCGCAA/CTCTCA 2 -- int10--------
    rs1822362851,2
    C--57186979(+) CCTCCC/GGAGTA 2 -- int10--------
    rs1863560561,2
    C--57186980(+) CTCCCA/GAGTAG 2 -- int10--------
    rs1907091011,2
    --57186996(+) ACTACA/GGGCAC 2 -- int10--------
    rs1828748311,2
    --57187482(+) AATACA/GGATCT 2 -- ut310--------
    rs1491146991,2
    --57187508(+) AGTTAC/TATTTA 2 -- ut310--------
    rs72085051,2
    C,F,A,H--57187729(+) CTACCA/GTTTTT 2 -- ut3133Minor allele frequency- G:0.39NS EA NA WA CSA 2924
    rs72082821,2
    C,F,A,H--57187795(+) AAATAC/TTAATT 2 -- ut3110Minor allele frequency- T:0.22NA CSA WA EA 374

    HapMap Linkage Disequilibrium report for SKA2 (57187308 - 57232800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SKA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv990139CNV Deletion20482838
    nsv908644CNV Loss21882294
    dgv3237n71CNV Loss21882294
    nsv833499CNV Loss17160897
    dgv3236n71CNV Loss21882294
    nsv908646CNV Loss21882294
    esv28194CNV Loss19812545
    dgv995e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for SKA2:    
    About MalaCards
    impetigo    acute poststreptococcal glomerulonephritis    rheumatic fever    acne
    glomerulonephritis

    3 diseases from the University of Copenhagen DISEASES database for SKA2:
    Acute poststreptococcal glomerulonephritis     Rheumatic fever     Impetigo

    SKA2 for disorders           About GeneDecksing


    Export disorders for SKA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SKA2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SKA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. (PubMed id 19289083)1, 2, 3 Welburn J.P.I.... Cheeseman I.M. (Dev. Cell 2009)
    2. Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. (PubMed id 18583474)1, 2, 3 Rice L.... Ray D.W. (J. Endocrinol. 2008)
    3. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. (PubMed id 17093495)1, 2, 3 Hanisch A.... Nigg E.A. (EMBO J. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Meta-analysis identifies four new loci associated with testicular germ cell tumor. (PubMed id 23666239)1 Chung C.C....Nathanson K.L. (Nat. Genet. 2013)
    7. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. (PubMed id 22371557)1 Chan Y.W....Santamaria A. (J. Cell Biol. 2012)
    8. Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface. (PubMed id 22483620)1 Jeyaprakash A.A....Conti E. (Mol. Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 348235 HGNC: 28006 AceView: FAM33A Ensembl:ENSG00000182628 euGenes: HUgn348235
    ECgene: SKA2 H-InvDB: SKA2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SKA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SKA2 gene:
    Search GeneIP for patents involving SKA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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