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Aliases for SKA1 Gene

Aliases for SKA1 Gene

  • Spindle And Kinetochore Associated Complex Subunit 1 2 3 5
  • C18orf24 3 4
  • Spindle And KT (Kinetochore) Associated 1 3
  • Chromosome 18 Open Reading Frame 24 2

External Ids for SKA1 Gene

Previous HGNC Symbols for SKA1 Gene

  • C18orf24

Previous GeneCards Identifiers for SKA1 Gene

  • GC18P046156
  • GC18P047902
  • GC18P044755

Summaries for SKA1 Gene

GeneCards Summary for SKA1 Gene

SKA1 (Spindle And Kinetochore Associated Complex Subunit 1) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for SKA1 Gene

  • Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKA1 Gene

Genomics for SKA1 Gene

Regulatory Elements for SKA1 Gene

Enhancers for SKA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SKA1 on UCSC Golden Path with GeneCards custom track

Promoters for SKA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SKA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SKA1 Gene

Chromosome:
18
Start:
50,374,995 bp from pter
End:
50,394,173 bp from pter
Size:
19,179 bases
Orientation:
Plus strand

Genomic View for SKA1 Gene

Genes around SKA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKA1 Gene

Proteins for SKA1 Gene

  • Protein details for SKA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BD8-SKA1_HUMAN
    Recommended name:
    Spindle and kinetochore-associated protein 1
    Protein Accession:
    Q96BD8
    Secondary Accessions:
    • B2R9Y6
    • B4E0P4

    Protein attributes for SKA1 Gene

    Size:
    255 amino acids
    Molecular mass:
    29484 Da
    Quaternary structure:
    • Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3 (PubMed:17093495). Forms a heterodimer with SKA2; the heterodimer interacting with SKA3 (PubMed:17093495, PubMed:19289083, PubMed:23085020). The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each heterodimer interacting with a molecule of the SKA3 homodimer (PubMed:19289083). The core SKA1 complex associates with microtubules and forms oligomeric assemblies (PubMed:17093495, PubMed:19289083). Interacts with microtubules; the interaction is direct (PubMed:19289083, PubMed:23085020). Interacts with SKA2 (PubMed:19289083). Interacts with SKA3 (PubMed:19289083, PubMed:23085020).

    Three dimensional structures from OCA and Proteopedia for SKA1 Gene

    Alternative splice isoforms for SKA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKA1 Gene

Proteomics data for SKA1 Gene at MOPED

Post-translational modifications for SKA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKA1 Gene

No data available for DME Specific Peptides for SKA1 Gene

Domains & Families for SKA1 Gene

Protein Domains for SKA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SKA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BD8

UniProtKB/Swiss-Prot:

SKA1_HUMAN :
  • Belongs to the SKA1 family.
Family:
  • Belongs to the SKA1 family.
genes like me logo Genes that share domains with SKA1: view

No data available for Gene Families for SKA1 Gene

Function for SKA1 Gene

Molecular function for SKA1 Gene

UniProtKB/Swiss-Prot Function:
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).
genes like me logo Genes that share phenotypes with SKA1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SKA1 Gene

Localization for SKA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKA1 Gene

Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner (PubMed:17093495). Localizes to both the mitotic spindle and kinetochore-associated proteins (PubMed:17093495). Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase (PubMed:17093495). {ECO:0000269 PubMed:17093495}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SKA1 Gene COMPARTMENTS Subcellular localization image for SKA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
peroxisome 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SKA1 Gene

Pathways & Interactions for SKA1 Gene

genes like me logo Genes that share pathways with SKA1: view

Pathways by source for SKA1 Gene

Gene Ontology (GO) - Biological Process for SKA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IMP 19289083
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IMP 19289083
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SKA1: view

No data available for SIGNOR curated interactions for SKA1 Gene

Drugs & Compounds for SKA1 Gene

No Compound Related Data Available

Transcripts for SKA1 Gene

Unigene Clusters for SKA1 Gene

Spindle and kinetochore associated complex subunit 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SKA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: -

Relevant External Links for SKA1 Gene

GeneLoc Exon Structure for
SKA1
ECgene alternative splicing isoforms for
SKA1

Expression for SKA1 Gene

mRNA expression in normal human tissues for SKA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SKA1 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for SKA1 Gene

This gene is overexpressed in Breast (45.0) and Fetal ovary (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SKA1 Gene



SOURCE GeneReport for Unigene cluster for SKA1 Gene Hs.134726

genes like me logo Genes that share expression patterns with SKA1: view

Protein tissue co-expression partners for SKA1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SKA1 Gene

Orthologs for SKA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SKA1 35
  • 89.99 (n)
  • 87.35 (a)
SKA1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SKA1 35
  • 85.1 (n)
  • 85.1 (a)
SKA1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ska1 35
  • 80.95 (n)
  • 75.79 (a)
Ska1 16
Ska1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SKA1 35
  • 99.35 (n)
  • 99.22 (a)
SKA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ska1 35
  • 82.21 (n)
  • 80.24 (a)
oppossum
(Monodelphis domestica)
Mammalia SKA1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SKA1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKA1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ska1 35
  • 59.23 (n)
  • 57.37 (a)
zebrafish
(Danio rerio)
Actinopterygii ska1 35
  • 53.31 (n)
  • 47.62 (a)
ska1 36
  • 46 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for SKA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKA1 Gene

ENSEMBL:
Gene Tree for SKA1 (if available)
TreeFam:
Gene Tree for SKA1 (if available)

Paralogs for SKA1 Gene

(3) SIMAP similar genes for SKA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SKA1: view

No data available for Paralogs for SKA1 Gene

Variants for SKA1 Gene

Sequence variations from dbSNP and Humsavar for SKA1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_030091 -

Structural Variations from Database of Genomic Variants (DGV) for SKA1 Gene

Variant ID Type Subtype PubMed ID
nsv909634 CNV Loss 21882294
nsv909635 CNV Gain 21882294
nsv909636 CNV Loss 21882294
dgv3418n71 CNV Loss 21882294
dgv3419n71 CNV Loss 21882294
nsv909640 CNV Loss 21882294
esv34028 CNV Loss 18971310
nsv515672 CNV Gain+Loss 19592680
nsv522433 CNV Gain 19592680
esv988818 CNV Gain 20482838
esv2665570 CNV Deletion 23128226

Variation tolerance for SKA1 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SKA1 Gene

Disorders for SKA1 Gene

Relevant External Links for SKA1

Genetic Association Database (GAD)
SKA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SKA1

No disorders were found for SKA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKA1 Gene

Publications for SKA1 Gene

  1. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. (PMID: 17093495) Hanisch A. … Nigg E.A. (EMBO J. 2006) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma. (PMID: 26063960) Dong C. … Ma B.L. (Dis. Markers 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SKA1 Gene

Sources for SKA1 Gene

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