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SKA1 Gene

protein-coding   GIFtS: 55
GCID: GC18P047902

Spindle And Kinetochore Associated Complex Subunit 1

(Previous name: chromosome 18 open reading frame 24)
(Previous symbol: C18orf24)
  See SKA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spindle And Kinetochore Associated Complex Subunit 11 2
C18orf241 2 3
Chromosome 18 Open Reading Frame 241
Spindle And Kinetochore-Associated Protein 12
Spindle And KT (Kinetochore) Associated 12

External Ids:    HGNC: 281091   Entrez Gene: 2201342   Ensembl: ENSG000001548397   UniProtKB: Q96BD83   

Export aliases for SKA1 gene to outside databases

Previous GC identifers: GC18P046156 GC18P044755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SKA1 Gene:
SKA1 (spindle and kinetochore associated complex subunit 1) is a protein-coding gene. Diseases associated with SKA1 include acute poststreptococcal glomerulonephritis. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot: SKA1_HUMAN, Q96BD8
Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is
essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes
undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1
complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules
as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in
a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SKA1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SKA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SKA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q21.1

SKA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SKA1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P047902:  view genomic region     (about GC identifiers)

Start:
47,901,365 bp from pter      End:
47,920,543 bp from pter
Size:
19,179 bases      Orientation:
plus strand

1 alternative location:
Chr18+,NW_003315956 82,829-101,975     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SKA1_HUMAN, Q96BD8 (See protein sequence)
Recommended Name: Spindle and kinetochore-associated protein 1  
Size: 255 amino acids; 29484 Da
Subunit: Component of the SKA1 complex, composed of SKA1, SKA2 and SKA3. Forms a heterodimer with SKA2; the
heterodimer interacting with SKA3. The core SKA1 complex is composed of 2 SKA1-SKA2 heterodimers, each
heterodimer interacting with a molecule of the SKA3 homodimer. The core SKA1 complex associates with microtubules
and forms oligomeric assemblies. Interacts directly with microtubules, SKA2 and SKA3
3 PDB 3D structures from and Proteopedia for SKA1:
4AJ5 (3D)        4C9Y (3D)        4CA0 (3D)    
Secondary accessions: B2R9Y6 B4E0P4
Alternative splicing: 2 isoforms:  Q96BD8-1   Q96BD8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SKA1: NX_Q96BD8

Explore proteomics data for SKA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SKA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034624.1  NP_659497.1  

    ENSEMBL proteins: 
     ENSP00000285116   ENSP00000381470   ENSP00000397222   ENSP00000467242   ENSP00000467559  
    Reactome Protein details: Q96BD8

    SKA1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009829 DUF1395

    Graphical View of Domain Structure for InterPro Entry Q96BD8

    ProtoNet protein and cluster: Q96BD8

    UniProtKB/Swiss-Prot: SKA1_HUMAN, Q96BD8
    Similarity: Belongs to the SKA1 family


    Find genes that share domains with SKA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SKA1_HUMAN, Q96BD8
    Function: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is
    essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes
    undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1
    complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules
    as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in
    a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17093495
    GO:0008017microtubule binding IDA19289083
         
    Find genes that share ontologies with SKA1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SKA1:
     Decreased cell number  Increased gamma-H2AX phosphory  Increased number of cells in m  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SKA1
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    miRNA
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    miRTarBase miRNAs that target SKA1:
    hsa-mir-215-5p (MIRT024386), hsa-mir-328-3p (MIRT043769), hsa-mir-193b-3p (MIRT016380), hsa-mir-192-5p (MIRT026316)

    Block miRNA regulation of human, mouse, rat SKA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SKA1:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidSKA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SKA1_HUMAN, Q96BD8: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the
    outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both
    the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule
    attachment from prometaphase, through mid-anaphase and then vanishes in telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3
    peroxisome2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000940condensed chromosome outer kinetochore IDA17093495
    GO:0005813centrosome ----
    GO:0005829cytosol TAS--
    GO:0005876spindle microtubule IDA17093495
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with SKA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SKA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with SKA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Reactome Pathways for SKA1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SKA1
    Interactions:

        Search GeneGlobe Interaction Network for SKA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SKA1 (Q96BD81, 2, 3 ENSP000002851164) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKA2Q8WVK71, 2, 3, ENSP000003334334EBI-741854,EBI-1773994 MINT-3391334 MINT-7277219 MINT-3391284 MINT-3391398 MINT-7277243 MINT-7277201 MINT-3391311 MINT-7277189 MINT-4051212 MINT-3391357 MINT-3391375 I2D: score=2 STRING: ENSP00000333433
    CENPEQ022242, 3, ENSP000002651484MINT-3391266 I2D: score=1 STRING: ENSP00000265148
    TUBA4AP683662, 3, ENSP000002484374MINT-3391222 I2D: score=1 STRING: ENSP00000248437
    SKA3Q8IX902, 3, ENSP000003194174MINT-7277243 MINT-7277267 MINT-7277189 MINT-7277201 MINT-7277219 I2D: score=1 STRING: ENSP00000319417
    NDC80O147772, 3, ENSP000002615974MINT-3391245 I2D: score=1 STRING: ENSP00000261597
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IMP19289083
    GO:0007067mitosis IMP19289083
    GO:0031110regulation of microtubule polymerization or depolymerization IDA19289083
    GO:0051301cell division IMP17093495

    Find genes that share ontologies with SKA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SKA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SKA1 gene (2 alternative transcripts): 
    NM_001039535.2  NM_145060.3  

    Unigene Cluster for SKA1:

    Spindle and kinetochore associated complex subunit 1
    Hs.134726  [show with all ESTs]
    Unigene Representative Sequence: NM_001039535
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285116(uc002let.3 uc010xdl.2) ENST00000398452(uc002leu.3)
    ENST00000417656 ENST00000488454 ENST00000494518
    miRNA
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    Block miRNA regulation of human, mouse, rat SKA1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SKA1:
    hsa-miR-586
    SwitchGear 3'UTR luciferase reporter plasmidSKA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SKA1
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    Addgene plasmids for SKA1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SKA1
      QuantiTect SYBR Green Assays in human, mouse, rat SKA1
      QuantiFast Probe-based Assays in human, mouse, rat SKA1

    Additional mRNA sequence: 

    AK303464.1 AK313968.1 BC005972.1 BC015606.2 

    6 DOTS entries:

    DT.99972832  DT.100755117  DT.430381  DT.101958079  DT.100755120  DT.91817183 

    Selected AceView cDNA sequences (see all 109):

    AI168606 AW592496 AA411396 AW204362 BX956145 AA465336 AI183401 BQ227737 
    CF144925 CF529689 AW236496 BC015606 AI801269 BQ649317 AI623303 AA121042 
    BQ064512 AI193377 AA830772 BQ651551 BM470268 AA568806 BQ896628 CF529657 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SKA1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                                                   
    SP2:                                                                        
    SP3:                                -                                       


    ECgene alternative splicing isoforms for SKA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SKA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGTTGT
    SKA1 Expression
    About this image


    SKA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Testis (Reproductive System)
    SKA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SKA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.134726
        Custom PCR Arrays for SKA1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SKA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SKA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SKA1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ska11 , 5 spindle and kinetochore associated complex subunit more1, 5 80.95(n)1
    75.79(a)1
      18 (50.67 cM)5
    664681  NM_025581.41  NP_079857.31 
     741952995 
    lizard
    (Anolis carolinensis)
    Reptilia SKA16
    spindle and kinetochore associated complex subunit...
    58(a)
    1 ↔ 1
    GL343471.1(268234-290160)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ska11 spindle and kinetochore associated complex subunit more 59.23(n)
    57.37(a)
      100144953  NM_001126525.1  NP_001119997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ska11 spindle and kinetochore associated complex subunit more 53.31(n)
    47.62(a)
      436865  NM_001002592.1  NP_001002592.1 


    ENSEMBL Gene Tree for SKA1 (if available)
    TreeFam Gene Tree for SKA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SKA1 gene
    3 SIMAP similar genes for SKA1 using alignment to 4 protein entries:     SKA1_HUMAN (see all proteins):
    ZNF506    VPS53    LIN7B

    Find genes that share paralogs with SKA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SKA1 (see all 518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs99730091,2
    C,F,H--47899397(+) ttcatC/Tggcca 2 -- us2k16Minor allele frequency- T:0.07NS EA WA CSA 418
    rs18088791,2
    C,F,A,H--47899555(-) tgacaG/TTTACA 2 -- us2k111Minor allele frequency- T:0.43NS EA NA WA 778
    rs1463099881,2
    --47899557(+) TAACTA/GTCAGG 2 -- us2k10--------
    rs20074021,2
    C,F,A--47899591(-) cagggG/Tatatg 2 -- us2k15Minor allele frequency- T:0.50NA CSA 10
    rs1442784531,2
    C--47899606(+) CTGCAC/TGTATA 2 -- us2k10--------
    rs1461054401,2
    --47899607(+) TGCACA/GTATAC 2 -- us2k10--------
    rs99730141,2
    C,F--47899703(+) aattcC/Tttctc 2 -- us2k1 trp31Minor allele frequency- T:0.50WA 2
    rs1872903631,2
    --47899737(+) TCCCCA/CACTGA 2 -- us2k10--------
    rs1498269751,2
    --47899865(+) TTTTCC/GGACTC 2 -- us2k10--------
    rs1908771971,2
    --47899876(+) AGCCCA/GCCTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SKA1 (47901365 - 47920543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SKA1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665570CNV Deletion23128226
    dgv3419n71CNV Loss21882294
    esv34028CNV Loss18971310
    nsv909640CNV Loss21882294
    nsv909636CNV Loss21882294
    dgv3418n71CNV Loss21882294
    nsv909634CNV Loss21882294
    nsv909635CNV Gain21882294
    nsv522433CNV Gain19592680
    esv988818CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SKA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SKA1:    
    About MalaCards
    acute poststreptococcal glomerulonephritis

    2 diseases from the University of Copenhagen DISEASES database for SKA1:
    Acute poststreptococcal glomerulonephritis     X-linked hypophosphatemia

    Find genes that share disorders with SKA1           About GenesLikeMe

    Genetic Association Database (GAD): SKA1

    Export disorders for SKA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SKA1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with SKA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. (PubMed id 17093495)1, 2, 3 Hanisch A.... Nigg E.A. (EMBO J. 2006)
    2. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. (PubMed id 19289083)1, 2 Welburn J.P.I.... Cheeseman I.M. (Dev. Cell 2009)
    3. Proteome analysis of the human mitotic spindle. (PubMed id 15561729)1, 2 Sauer G.... Sillje H.H.W. (Mol. Cell. Proteomics 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. (PubMed id 22371557)1 Chan Y.W....Santamaria A. (J. Cell Biol. 2012)
    7. Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface. (PubMed id 22483620)1 Jeyaprakash A.A....Conti E. (Mol. Cell 2012)
    8. The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. (PubMed id 23085020)1 Schmidt J.C....Cheeseman I.M. (Dev. Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 220134 HGNC: 28109 AceView: C18orf24 Ensembl:ENSG00000154839 euGenes: HUgn220134
    ECgene: SKA1 H-InvDB: SKA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SKA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SKA1 gene:
    Search GeneIP for patents involving SKA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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