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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIX4 Gene

protein-coding   GIFtS: 52
GCID: GC14M061176

SIX homeobox 4

(Previous names: sine oculis homeobox (Drosophila) homolog 4, sine oculis...)
 Explore 7 diseases affiliated with
SIX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SIX4    

Aliases
for SIX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SIX Homeobox 41 2
AREC31 2
Sine Oculis Homeobox Homolog 42 3
Sine Oculis Homeobox (Drosophila) Homolog 41
Sine Oculis Homeobox Homolog 4 (Drosophila)1
Homeobox Protein SIX42

External Ids:    HGNC: 108901   Entrez Gene: 518042   Ensembl: ENSG000001006257   OMIM: 6063425   UniProtKB: Q9UIU63   

Export aliases for SIX4 gene to outside databases

Previous GC identifers: GC14M058506 GC14M054973 GC14M059170 GC14M060249 GC14M041338


Summaries
for SIX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SIX4:
This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein
required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and
may have a role in the differentiation or maturation of neuronal cells. (provided by RefSeq, May 2010)

Gene Wiki entry for SIX4


Genomic Views
for SIX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIX4 gene promoter:
         Egr-3   Lmo2   MyoD   Nkx2-5   AP-2gamma   E47   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

SIX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIX4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M061176:  view genomic region     (about GC identifiers)

Start:
 61,176,246 bp from pter      End:
 61,191,066 bp from pter
Size:
 14,821 bases      Orientation:
 minus strand

Proteins
for SIX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIX4_HUMAN, Q9UIU6 (See protein sequence)
Recommended Name: Homeobox protein SIX4  
Size: 781 amino acids; 82933 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA86223.1; Type=Erroneous initiation; Sequence=EAW80786.1; Type=Erroneous initiation;
Secondary accessions: Q4QQH5 Q4V764

Explore the universe of human proteins at neXtProt for SIX4: NX_Q9UIU6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UIU6

    • SIX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_059116.3  
    ENSEMBL proteins: 
     ENSP00000216513   ENSP00000451537   ENSP00000450761  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: SIX4
    OriGene Custom Protein Services for SIX4 
    GenScript Custom Purified and Recombinant Proteins Services for SIX4
    Novus Biologicals SIX4 Protein
    Novus Biologicals SIX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SIX4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    SIX4 for ontologies           About GeneDecksing



    SIX4 Antibody Products: 
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    Uscn Antibodies for SIX4
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    Uscn ELISAs and CLIAs for SIX4

    Protein Domains /
    Families
    for SIX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SIX4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9UIU6

    ProtoNet protein and cluster: Q9UIU6

    UniProtKB/Swiss-Prot: SIX4_HUMAN, Q9UIU6
    Similarity: Belongs to the SIX/Sine oculis homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for SIX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
         Genatlas biochemistry entry for SIX4:
    Drosophila sine oculis homolog SIX4 homeo box encoding gene,expressed in mouse in the nucleus of neuronal cells in
    developing brain,spinal cord and various ganglia,not deleted in a adult tissues,also expressed in developing mouse
    retina,putatively involved in differentiation or maturation of neuronal cells and retinal development

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SIX4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIX4
    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate SIX4 (see all 112):
    hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-15a hsa-miR-30d hsa-miR-30a hsa-miR-629 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmid: SIX4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIX4 (see all 7)
    OriGene shRNA RFP: SIX4
    OriGene siRNA: SIX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SIX4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIX4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIX4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SIX4 (NM_017420)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIX4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SIX4
    Search LifeMap BioReagents cell lines for SIX4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIX4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    SIX4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SIX4:
     Increased gamma-H2AX phosphory 

    Animal Models:
         14 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Six4):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  limbs/digits/tail  mortality/aging  muscle 
     nervous system  normal  skeleton  vision/eye 

    SIX4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SIX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIX4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SIX4 (Q9UIU62, 3 ENSP000002165134) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KDM6AO155502, 3, ENSP000003672034MINT-7949384 I2D: score=2 STRING: ENSP00000367203
    EYA2O001673, ENSP000003336404I2D: score=2 STRING: ENSP00000333640
    EYA3Q995043, ENSP000003629784I2D: score=1 STRING: ENSP00000362978
    KBTBD7Q8WVZ93I2D: score=1 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008582regulation of synaptic growth at neuromuscular junction IEA--
    GO:0009653anatomical structure morphogenesis TAS10640827
    GO:0032880regulation of protein localization IEA--
    GO:0042472inner ear morphogenesis IEA--


    SIX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SIX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIX4
    Search CenterWatch for drugs/clinical trials and news about SIX4 

    Transcripts
    for SIX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SIX4 gene: 
    NM_017420.4  

    Unigene Cluster for SIX4:

    SIX homeobox 4
    Hs.97849  [show with all ESTs]
    Unigene Representative Sequence: NM_017420
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216513(uc001xfc.3) ENST00000554079 ENST00000556952(uc010app.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: SIX4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIX4
    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate SIX4 (see all 112):
    hsa-miR-124* hsa-miR-548j hsa-miR-193a-3p hsa-miR-15a hsa-miR-30d hsa-miR-30a hsa-miR-629 hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmid: SIX4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIX4 (see all 7)
    OriGene shRNA RFP: SIX4
    OriGene siRNA: SIX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIX4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIX4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIX4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SIX4 (NM_017420)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIX4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIX4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIX4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIX4

    Additional cDNA sequence: 

    AF032107.1 AK309358.1 BC098135.1 BC098282.1 BC099722.1 BC101934.1 

    1 DOTS entry:

    DT.40301139 

    6 AceView cDNA sequences:

    NM_017420 BG977380 AF032107 AA375786 BP365126 BF678614 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SIX4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:        -     -                     
    SP2:                                    


    ECgene alternative splicing isoforms for SIX4

    Expression
    for SIX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SIX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/46 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 46) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMyoblastsSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMyoblastsSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

    See SIX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIX4

    SOURCE GeneReport for Unigene cluster: Hs.97849
        SABiosciences Expression via Pathway-Focused PCR Array including SIX4: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIX4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIX4

    Orthologs
    for SIX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SIX4 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SIX41 SIX homeobox 4 78.94(n)
    80.39(a)    		   395601  XM_003641442.1  XP_003641490.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SIX46
    		 --
    		 51(a)
    		 1 ↔ 1
    		 GL343261.1(729273-761613)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.73842 Xenopus laevis transcribed sequence with weak similarity more 75.32(n)    48041179 
    zebrafish
    (Danio rerio)    		 Actinopterygii AB040709.12   -- 82.06(n)   65232  AB040709.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Six43 gonad development RNA polymerase II
    transcription more    		 65(a)   77E6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-333   -- 53(a)
    (best of 3)    		   V(5322702-5324303)   --


    ENSEMBL Gene Tree for SIX4 (if available)
    TreeFam Gene Tree for SIX4 (if available) 

    Paralogs
    for SIX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIX4 gene
    SIX52  SIX22  SIX12  SIX32  SIX62  
    8 SIMAP similar genes for SIX4 using alignment to 3 protein entries:     SIX4_HUMAN (see all proteins):
    AREC3    SIX1    SIX6    SIX2    SIX3    SIX5
    NKX2-5    WUGSC

    SIX4 for paralogs           About GeneDecksing



    Genomic Variants
    for SIX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/262 NCBI SNPs in SIX4 are shown (see all 262)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs776012791,2
    		F,--61175965(+) GGAAGG/AGGAAG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1113880921,2
    		C,--61175976(+) GTACAC/ATTCTT 1 -- ds50012Minor allele frequency- A:0.04NA 122
    rs1827989351,2
    		--61176260(+) GGTATA/GTATAA 1 -- ut310--------
    rs1501339241,2
    		--61176339(+) CTTAAC/TTGTCC 1 -- ut310--------
    rs101337771,2
    		C,F,H--61176459(+) GCAGTA/GAAGAC 1 -- ut31 ese35Minor allele frequency- G:0.01NS EA CSA 422
    rs21808301,2
    		C,F,O,A,H,--61176485(-) TGTATG/ATCATG 1 -- ut31 ese326Minor allele frequency- A:0.21NS EA NA WA CSA 2496
    rs1383360871,2
    		--61176499(+) TGTAT-/AGAGTTT 1 -- ut310--------
    rs727222301,2
    		C,F,--61176886(+) ACACAT/AGCCCA 1 -- ut311Minor allele frequency- A:0.07NA 120
    rs1871211151,2
    		--61176937(+) AGAGAA/GATTTA 1 -- ut310--------
    rs1456319021,2
    		--61177075(+) GAGATA/GTAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SIX4 (61176246 - 61191066 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SIX4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIX4
    DNA2.0 Custom Variant and Variant Library Synthesis for SIX4

    Disorders / Diseases
    for SIX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SIX4 for disorders           About GeneDecksing

    OMIM gene information: 606342    OMIM disorders: --

    7 diseases for SIX4:    About MalaCards
    posterior polar cataract    myocardial stunning    anophthalmia    neuronitis
    cataract    pharyngitis    retinitis

    1 disease from the University of Copenhagen DISEASES database for SIX4:
    Myocardial infarction

    Export disorders for SIX4 gene to outside databases

    Publications
    for SIX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIX4 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SIX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosome mapping of the human SIX4 and murine Six4 genes. (PubMed id 10640827)1, 2, 3 Ozaki H.... Kawakami K. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies. (PubMed id 10512683)1, 3 Gallardo M.E....Rodriguez de Cordoba S. (1999)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    7. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    8. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Six3 and Six6 activity is modulated by members of the groucho family. (PubMed id 12441302)1 Lopez-Rios J....Bovolenta P. (2003)

    External Searches for SIX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SIX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51804 HGNC: 10890 AceView: SIX4 Ensembl:ENSG00000100625 euGenes: HUgn51804
    ECgene: SIX4 H-InvDB: SIX4

    Other Databases showing SIX4 gene

    (According to HUGE)
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    Specialized Databases showing SIX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SIX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SIX4 gene:
    Search GeneIP for patents involving SIX4

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