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SIX2 Gene

protein-coding   GIFtS: 51
GCID: GC02M045232

SIX Homeobox 2

(Previous names: sine oculis homeobox (Drosophila) homolog 2, sine oculis...)
  See SIX2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SIX Homeobox 21 2
Sine Oculis Homeobox Homolog 22 3
Sine Oculis Homeobox (Drosophila) Homolog 21
Sine Oculis Homeobox Homolog 2 (Drosophila)1
Homeobox Protein SIX22

External Ids:    HGNC: 108881   Entrez Gene: 107362   Ensembl: ENSG000001705777   OMIM: 6049945   UniProtKB: Q9NPC83   

Export aliases for SIX2 gene to outside databases

Previous GC identifers: GC02M045231 GC02M045401 GC02M045206 GC02M045143 GC02M044969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIX2 Gene:
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine
oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene
family, may be involved in limb or eye development. (provided by RefSeq, Dec 2008)

GeneCards Summary for SIX2 Gene:
SIX2 (SIX homeobox 2) is a protein-coding gene. Diseases associated with SIX2 include microtia. GO annotations related to this gene include protein complex binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SIX4.

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
Function: May be involved in limb tendon and ligament development (By similarity)

Gene Wiki entry for SIX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIX2 gene promoter:
         NF-1   NF-1/L   Nkx2-5   CUTL1   STAT5A   Tal-1beta   N-Myc   IRF-7A   NF-kappaB1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIX2 promoter sequence
   Search Chromatin IP Primers for SIX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

SIX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M045232:  view genomic region     (about GC identifiers)

Start:
45,232,300 bp from pter      End:
45,236,569 bp from pter
Size:
4,270 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8 (See protein sequence)
Recommended Name: Homeobox protein SIX2  
Size: 291 amino acids; 32286 Da
Secondary accessions: Q9BXH7

Explore the universe of human proteins at neXtProt for SIX2: NX_Q9NPC8

Explore proteomics data for SIX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SIX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_058628.3  
    ENSEMBL proteins: 
     ENSP00000304502  

    SIX2 Human Recombinant Protein Products:

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    Novus Biologicals SIX2 Protein
    Novus Biologicals SIX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIX2

     
    Search eBioscience for Proteins for SIX2 

     
    antibodies-online proteins for SIX2 (3 products) 

     
    antibodies-online peptides for SIX2

    SIX2 Antibody Products:

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    antibodies-online antibodies for SIX2 (31 products) 

    SIX2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SIX2
    Cloud-Clone Corp. CLIAs for SIX2
    Search eBioscience for ELISAs for SIX2 
    antibodies-online kits for SIX2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SIX: Homeoboxes / SINE class

    3 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9NPC8

    ProtoNet protein and cluster: Q9NPC8

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
    Similarity: Belongs to the SIX/Sine oculis homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with SIX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIX2_HUMAN, Q9NPC8
    Function: May be involved in limb tendon and ligament development (By similarity)

         Genatlas biochemistry entry for SIX2:
    Drosophila sine oculis homolog SIX2 homeo box encoding gene,expressed in mesenchyme in mouse

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0032403protein complex binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with SIX2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Six2):
     cardiovascular system  cellular  mortality/aging  normal  renal/urinary system 

    Find genes that share phenotypes with SIX2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Six2tm1Gco for SIX2

       genOway: Develop your customized and physiologically relevant rodent model for SIX2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SIX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIX2 (see all 25):
    hsa-miR-320a hsa-miR-623 hsa-miR-3938 hsa-miR-181c hsa-miR-4263 hsa-miR-340 hsa-miR-1184 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSIX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIX2
    Predesigned siRNA for gene silencing in human, mouse, rat SIX2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SIX2 (see all 6)
    OriGene ORF clones in mouse, rat for SIX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIX2 (NM_016932)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIX2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIX2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIX2_HUMAN, Q9NPC8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SIX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including SIX2: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SIX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIX2 (Q9NPC83 ENSP000003045024) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EYA1Q995023, ENSP000003426264I2D: score=2 STRING: ENSP00000342626
    AESQ081173, ENSP000002215614I2D: score=1 STRING: ENSP00000221561
    EYA3Q995043, ENSP000003629784I2D: score=1 STRING: ENSP00000362978
    TLE1Q047243, ENSP000003656824I2D: score=2 STRING: ENSP00000365682
    PAX6ENSP000003684014STRING: ENSP00000368401
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development ----
    GO:0001822kidney development IMP18305125
    GO:0002062chondrocyte differentiation IEA--
    GO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with SIX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIX2 gene: 
    NM_016932.4  

    Unigene Cluster for SIX2:

    SIX homeobox 2
    Hs.101937  [show with all ESTs]
    Unigene Representative Sequence: NM_016932
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303077(uc002ruo.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat SIX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SIX2 (see all 25):
    hsa-miR-320a hsa-miR-623 hsa-miR-3938 hsa-miR-181c hsa-miR-4263 hsa-miR-340 hsa-miR-1184 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidSIX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SIX2
    Predesigned siRNA for gene silencing in human, mouse, rat SIX2
    Clone
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    OriGene clones in human, mouse for SIX2 (see all 6)
    OriGene ORF clones in mouse, rat for SIX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SIX2 (NM_016932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIX2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SIX2
    OriGene qSTAR qPCR primer pairs in human, mouse for SIX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIX2
      QuantiTect SYBR Green Assays in human, mouse, rat SIX2
      QuantiFast Probe-based Assays in human, mouse, rat SIX2

    Additional mRNA sequence: 

    AF136940.1 AF332196.1 AF332197.1 BC024033.2 BT020100.1 

    2 DOTS entries:

    DT.92417765  DT.92417764 

    Selected AceView cDNA sequences (see all 35):

    AF332197 CR595397 BX280822 AI697859 BQ071675 BC024033 AA808542 AF136940 
    BG829041 NM_016932 AF332196 AI697804 AI630789 AW078611 BX341976 BU543706 
    BX347429 AI811914 CA413774 BM999458 BQ944758 BX400894 BM017907 BE328432 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAATGTTCT
    SIX2 Expression
    About this image


    SIX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 11 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
             Human kidney epithelial cell spheroids
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    SIX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.101937

    UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
    Tissue specificity: Strongly expressed in skeletal muscle. Expressed in Wilms' tumor and in the cap mesenchyme of
    fetal kidney (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SIX2: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SIX2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Six21 , 5 sine oculis-related homeobox 2 homolog (Drosophila)5
    sine oculis-related homeobox 21
    92.33(n)1
    97.59(a)1
      17 (55.72 cM)5
    204721  NM_011380.21  NP_035510.11 
     856842685 
    chicken
    (Gallus gallus)
    Aves SIX21 SIX homeobox 2 83.92(n)
    90.49(a)
      724086  NM_001044695.1  NP_001038160.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIX26
    SIX homeobox 2
    92(a)
    1 ↔ 1
    GL343284.1(1226958-1247234)
    African clawed frog
    (Xenopus laevis)
    Amphibia six2-A2 homeobox protein SIX2 85.27(n)    AF108810.2 
    zebrafish
    (Danio rerio)
    Actinopterygii AB040708.12   -- 76.75(n)   83415  AB040708.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta so3 circadian rhythm transcription factor 86(a)
    (best of 2)
      2 43C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-333   -- 59(a)
    (best of 3)
      V(5322702-5324303)   --


    ENSEMBL Gene Tree for SIX2 (if available)
    TreeFam Gene Tree for SIX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIX2 gene
    SIX42  SIX52  SIX12  SIX32  SIX62  
    6 SIMAP similar genes for SIX2 using alignment to 2 protein entries:     SIX2_HUMAN (see all proteins):
    SIX1    AREC3    SIX3    SIX6    SIX4    SIX5

    Find genes that share paralogs with SIX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIX2 (see all 158)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413683441,2
    --45099026(+) GCTTAA/CGTCTG 1 -- int10--------
    rs1161387261,2
    C,F--45099359(+) CACCTA/GGCGAC 1 -- int11Minor allele frequency- G:0.01NA 120
    rs1469870691,2
    --45099376(+) AAGTCA/GTGTGT 1 -- int10--------
    rs1379807021,2
    --45099392(+) AAGGCA/GTCTGG 1 -- int10--------
    rs1435258531,2
    C--45099437(+) AGAACA/GGCCCA 1 -- int10--------
    rs800965841,2
    C,F--45099449(+) CCGGGG/ATGTCG 1 -- int12Minor allele frequency- A:0.05WA EA 238
    rs1908464241,2
    --45099600(+) ATTACA/GGGGAG 1 -- ut310--------
    rs779565191,2
    C--45099717(+) GGGGCC/GTATGA 1 -- ut310--------
    rs802898741,2
    C,F--45099750(+) TGTGGC/TGCTGC 1 -- ut311Minor allele frequency- T:0.05EA 120
    rs1823256071,2
    --45099862(+) AAAGTC/TCCTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SIX2 (45232300 - 45236569 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SIX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2711CNV Loss18451855

    Human Gene Mutation Database (HGMD): SIX2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIX2
    DNA2.0 Custom Variant and Variant Library Synthesis for SIX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604994    OMIM disorders: --

    1 disease for SIX2:    
    About MalaCards
    microtia


    Find genes that share disorders with SIX2           About GenesLikeMe

    Genetic Association Database (GAD): SIX2

    Export disorders for SIX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIX2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SIX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. (PubMed id 10773454)1, 2, 9 Boucher C.A.... Bailey M.E.S. (Gene 2000)
    2. SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor. (PubMed id 22703800)1, 2 Murphy A.J....Lovvorn H.N. (J. Pediatr. Surg. 2012)
    3. Familial syndromic esophageal atresia maps to 2p23-p24. (PubMed id 10677303)1, 2 Celli J....Brunner H.G. (Am. J. Hum. Genet. 2000)
    4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    5. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PubMed id 21909109)1 Kim Y.J....Cho Y.S. (Nat. Genet. 2011)
    6. Mutational analysis of HOXA2 and SIX2 in a Bronx population with isolated microtia. (PubMed id 20542577)1 Monks D.C....Babcock M. (Int. J. Pediatr. Otorhinolaryngol. 2010)
    7. The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. (PubMed id 18989625)1 Kumar J.P. (Cell. Mol. Life Sci. 2009)
    8. The six family of homeobox genes in development and cancer. (PubMed id 19055944)1 Christensen K.L....Ford H.L. (Adv. Cancer Res. 2008)
    9. SIX2 and BMP4 mutations associate with anomalous kidney development. (PubMed id 18305125)1 Weber S.... Burdine R.D. (J. Am. Soc. Nephrol. 2008)
    10. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10736 HGNC: 10888 AceView: SIX2 Ensembl:ENSG00000170577 euGenes: HUgn10736
    ECgene: SIX2 H-InvDB: SIX2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIX2 gene:
    Search GeneIP for patents involving SIX2

    GeneCards and IP:
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