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Aliases for SIVA1 Gene

Aliases for SIVA1 Gene

  • SIVA1, Apoptosis-Inducing Factor 2 3
  • CD27BP 3 4
  • SIVA 3 4
  • Apoptosis Regulatory Protein Siva 3
  • CD27-Binding (Siva) Protein 3
  • CD27-Binding Protein 4
  • Siva-1 3
  • Siva-2 3

External Ids for SIVA1 Gene

Summaries for SIVA1 Gene

Entrez Gene Summary for SIVA1 Gene

  • This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIVA1 Gene

SIVA1 (SIVA1, Apoptosis-Inducing Factor) is a Protein Coding gene. Among its related pathways are Apoptosis Signaling Pathways and Apoptosis and Autophagy. GO annotations related to this gene include virus receptor activity and CD27 receptor binding.

UniProtKB/Swiss-Prot for SIVA1 Gene

  • Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Gene Wiki entry for SIVA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIVA1 Gene

Genomics for SIVA1 Gene

Genomic Location for SIVA1 Gene

104,753,100 bp from pter
104,768,494 bp from pter
15,395 bases
Plus strand

Genomic View for SIVA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIVA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIVA1 Gene

Regulatory Elements for SIVA1 Gene

Proteins for SIVA1 Gene

  • Protein details for SIVA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apoptosis regulatory protein Siva
    Protein Accession:
    Secondary Accessions:
    • Q96P98
    • Q9UPD6

    Protein attributes for SIVA1 Gene

    175 amino acids
    Molecular mass:
    18695 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Isoform 1 binds 3 Zn(2+) ions.;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Isoform 2 binds 2 Zn(2+) ions.;
    Quaternary structure:
    • Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.
    • Sequence=AAC51372.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD50057.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIVA1 Gene


neXtProt entry for SIVA1 Gene

Proteomics data for SIVA1 Gene at MOPED

Post-translational modifications for SIVA1 Gene

  • Phosphorylated by ABL2/ARG in response to oxidative stress.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys17, Lys41, and Lys124

Other Protein References for SIVA1 Gene

No data available for DME Specific Peptides for SIVA1 Gene

Domains for SIVA1 Gene

Protein Domains for SIVA1 Gene


Suggested Antigen Peptide Sequences for SIVA1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIVA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SIVA1 Gene

Function for SIVA1 Gene

Molecular function for SIVA1 Gene

UniProtKB/Swiss-Prot Function: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Gene Ontology (GO) - Molecular Function for SIVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity ISS --
GO:0005175 CD27 receptor binding IPI 16683188
GO:0005515 protein binding IPI 12011449
GO:0008270 zinc ion binding IDA 16683188
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SIVA1: view

Phenotypes for SIVA1 Gene

GenomeRNAi human phenotypes for SIVA1:
genes like me logo Genes that share phenotypes with SIVA1: view

miRNA for SIVA1 Gene

miRTarBase miRNAs that target SIVA1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SIVA1 Gene

Localization for SIVA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIVA1 Gene

Cytoplasm. Nucleus. Note=In the nucleus, accumulates in dot-like structures.

Subcellular locations from

Jensen Localization Image for SIVA1 Gene COMPARTMENTS Subcellular localization image for SIVA1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 15034012
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA 12011449
genes like me logo Genes that share ontologies with SIVA1: view

Pathways for SIVA1 Gene

genes like me logo Genes that share pathways with SIVA1: view

Pathways by source for SIVA1 Gene

1 GeneGo (Thomson Reuters) pathway for SIVA1 Gene
2 Qiagen pathways for SIVA1 Gene
2 Cell Signaling Technology pathways for SIVA1 Gene

Gene Ontology (GO) - Biological Process for SIVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006924 activation-induced cell death of T cells IDA 16491128
GO:0009615 response to virus --
GO:0016032 viral process --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 16491128
GO:0046718 viral entry into host cell ISS --
genes like me logo Genes that share ontologies with SIVA1: view

Compounds for SIVA1 Gene


Pharmaceutical: Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1
genes like me logo Genes that share compounds with SIVA1: view

Transcripts for SIVA1 Gene

Unigene Clusters for SIVA1 Gene

SIVA1, apoptosis-inducing factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIVA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for SIVA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIVA1 Gene

mRNA expression in normal human tissues for SIVA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIVA1 Gene

SOURCE GeneReport for Unigene cluster for SIVA1 Gene Hs.112058

mRNA Expression by UniProt/SwissProt for SIVA1 Gene

Tissue specificity: Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon
genes like me logo Genes that share expressions with SIVA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SIVA1 Gene

Orthologs for SIVA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIVA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIVA1 35
  • 98.86 (n)
  • 99.43 (a)
SIVA1 36
  • 99 (a)
(Bos Taurus)
Mammalia SIVA1 35
  • 80.84 (n)
  • 77.59 (a)
SIVA1 36
  • 77 (a)
(Canis familiaris)
Mammalia SIVA1 35
  • 83.24 (n)
  • 78.29 (a)
(Mus musculus)
Mammalia Gm16380 36
  • 66 (a)
Siva1 35
  • 73.95 (n)
  • 71.26 (a)
Siva1 16
Siva1 36
  • 71 (a)
(Monodelphis domestica)
Mammalia SIVA1 36
  • 56 (a)
(Rattus norvegicus)
Mammalia Siva1 35
  • 78.13 (n)
  • 75.8 (a)
(Gallus gallus)
Aves SIVA1 35
  • 58.91 (n)
  • 51.74 (a)
SIVA1 36
  • 49 (a)
(Anolis carolinensis)
Reptilia SIVA1 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia siva1 35
  • 56.12 (n)
  • 49.37 (a)
(Danio rerio)
Actinopterygii siva1 35
  • 52.3 (n)
  • 43.11 (a)
siva1 36
  • 41 (a)
Species with no ortholog for SIVA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIVA1 Gene

Gene Tree for SIVA1 (if available)
Gene Tree for SIVA1 (if available)

Paralogs for SIVA1 Gene

No data available for Paralogs for SIVA1 Gene

Variants for SIVA1 Gene

Sequence variations from dbSNP and Humsavar for SIVA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs14905 -- 104,759,551(+) ACGAG(C/T)GCTCG utr-variant-3-prime
rs1133044 -- 104,759,642(+) AACCT(C/G)TTTAT utr-variant-3-prime
rs3809454 -- 104,752,732(-) GTGCA(G/T)CGGGG upstream-variant-2KB
rs5811150 -- 104,758,492(+) CTTTC(-/TT)TTTTT intron-variant
rs8006310 -- 104,752,139(+) GCGGC(A/G)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIVA1 Gene

Variant ID Type Subtype PubMed ID
dgv2008n71 CNV Loss 21882294
dgv2009n71 CNV Loss 21882294
nsv902389 CNV Loss 21882294
nsv470678 CNV Gain 18288195
nsv470677 CNV Loss 18288195
dgv2012n71 CNV Loss 21882294
dgv2013n71 CNV Loss 21882294
nsv517038 CNV Loss 19592680
nsv820230 CNV Gain 19587683
dgv2015n71 CNV Loss 21882294
nsv456455 CNV Loss 19166990
nsv902407 CNV Gain 21882294
nsv827077 CNV Gain 20364138

Relevant External Links for SIVA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIVA1 Gene

Disorders for SIVA1 Gene

No disorders were found for SIVA1 Gene.

No data available for UniProtKB/Swiss-Prot for SIVA1 Gene

Publications for SIVA1 Gene

  1. Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva. (PMID: 10756043) Henke A. … Munder T. (J. Virol. 2000) 3 4 23
  2. The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva. (PMID: 11601913) Henke A. … Munder T. (Virology 2001) 3 4 23
  3. Siva-1 and an alternative splice form lacking the death domain, Siva- 2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway. (PMID: 15034012) Py B. … Benichou S. (J. Immunol. 2004) 3 4 23
  4. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. (PMID: 9177220) Prasad K.V.S. … Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  5. The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress. (PMID: 11278261) Cao C. … Kufe D. (J. Biol. Chem. 2001) 3 4

Products for SIVA1 Gene

Sources for SIVA1 Gene

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