Aliases for SIVA1 Gene
External Ids for SIVA1 Gene
Previous GeneCards Identifiers for SIVA1 Gene
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIVA1 Gene
SIVA1 (SIVA1, Apoptosis-Inducing Factor) is a Protein Coding gene. Among its related pathways are Apoptosis Signaling Pathways and Apoptosis and Autophagy. GO annotations related to this gene include virus receptor activity and CD27 receptor binding.
UniProtKB/Swiss-Prot for SIVA1 Gene
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.