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Aliases for SIVA1 Gene

Aliases for SIVA1 Gene

  • SIVA1 Apoptosis Inducing Factor 2 3
  • SIVA1, Apoptosis-Inducing Factor 3 5
  • CD27BP 3 4
  • SIVA 3 4
  • CD27-Binding (Siva) Protein 3
  • CD27-Binding Protein 4
  • Siva-1 3
  • Siva-2 3

External Ids for SIVA1 Gene

Previous GeneCards Identifiers for SIVA1 Gene

  • GC14P104291
  • GC14P105219
  • GC14P085416

Summaries for SIVA1 Gene

Entrez Gene Summary for SIVA1 Gene

  • This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIVA1 Gene

SIVA1 (SIVA1 Apoptosis Inducing Factor) is a Protein Coding gene. Diseases associated with SIVA1 include Scapuloperoneal Myopathy. Among its related pathways are p53 Pathway (RnD) and NF-kappaB Signaling. GO annotations related to this gene include virus receptor activity and CD27 receptor binding.

UniProtKB/Swiss-Prot for SIVA1 Gene

  • Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Gene Wiki entry for SIVA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIVA1 Gene

Genomics for SIVA1 Gene

Regulatory Elements for SIVA1 Gene

Enhancers for SIVA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIVA1 on UCSC Golden Path with GeneCards custom track

Promoters for SIVA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SIVA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIVA1 Gene

104,752,420 bp from pter
104,768,494 bp from pter
16,075 bases
Plus strand

Genomic View for SIVA1 Gene

Genes around SIVA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIVA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIVA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIVA1 Gene

Proteins for SIVA1 Gene

  • Protein details for SIVA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Apoptosis regulatory protein Siva
    Protein Accession:
    Secondary Accessions:
    • Q96P98
    • Q9UPD6

    Protein attributes for SIVA1 Gene

    175 amino acids
    Molecular mass:
    18695 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2.
    • Sequence=AAC51372.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAD50057.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SIVA1 Gene


neXtProt entry for SIVA1 Gene

Proteomics data for SIVA1 Gene at MOPED

Post-translational modifications for SIVA1 Gene

  • Phosphorylated by ABL2/ARG in response to oxidative stress.
  • Ubiquitination at Lys 17, Lys 41, and Lys 124
  • Modification sites at PhosphoSitePlus

Other Protein References for SIVA1 Gene

No data available for DME Specific Peptides for SIVA1 Gene

Domains & Families for SIVA1 Gene

Protein Domains for SIVA1 Gene


Suggested Antigen Peptide Sequences for SIVA1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIVA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SIVA1 Gene

Function for SIVA1 Gene

Molecular function for SIVA1 Gene

UniProtKB/Swiss-Prot Function:
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Gene Ontology (GO) - Molecular Function for SIVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity ISS --
GO:0008270 zinc ion binding IDA 16683188
genes like me logo Genes that share ontologies with SIVA1: view
genes like me logo Genes that share phenotypes with SIVA1: view

Animal Models for SIVA1 Gene

MGI Knock Outs for SIVA1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIVA1 Gene

Localization for SIVA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIVA1 Gene

Cytoplasm. Nucleus. Note=In the nucleus, accumulates in dot-like structures.

Subcellular locations from

Jensen Localization Image for SIVA1 Gene COMPARTMENTS Subcellular localization image for SIVA1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SIVA1 Gene

Pathways & Interactions for SIVA1 Gene

genes like me logo Genes that share pathways with SIVA1: view

Pathways by source for SIVA1 Gene

2 Cell Signaling Technology pathways for SIVA1 Gene
1 GeneGo (Thomson Reuters) pathway for SIVA1 Gene
1 R&D Systems pathway for SIVA1 Gene
2 Qiagen pathways for SIVA1 Gene

SIGNOR curated interactions for SIVA1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SIVA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006924 activation-induced cell death of T cells IDA 16491128
GO:0097191 extrinsic apoptotic signaling pathway IDA 9177220
genes like me logo Genes that share ontologies with SIVA1: view

Drugs & Compounds for SIVA1 Gene

No Compound Related Data Available

Transcripts for SIVA1 Gene

Unigene Clusters for SIVA1 Gene

SIVA1, apoptosis-inducing factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIVA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for SIVA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIVA1 Gene

mRNA expression in normal human tissues for SIVA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIVA1 Gene

SOURCE GeneReport for Unigene cluster for SIVA1 Gene Hs.112058

mRNA Expression by UniProt/SwissProt for SIVA1 Gene

Tissue specificity: Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
genes like me logo Genes that share expression patterns with SIVA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for SIVA1 Gene

Orthologs for SIVA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIVA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SIVA1 35
  • 80.84 (n)
  • 77.59 (a)
SIVA1 36
  • 77 (a)
(Canis familiaris)
Mammalia SIVA1 35
  • 83.24 (n)
  • 78.29 (a)
(Mus musculus)
Mammalia Siva1 35
  • 73.95 (n)
  • 71.26 (a)
Siva1 16
Gm16380 36
  • 66 (a)
Siva1 36
  • 71 (a)
(Pan troglodytes)
Mammalia SIVA1 35
  • 98.86 (n)
  • 99.43 (a)
SIVA1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Siva1 35
  • 78.13 (n)
  • 75.8 (a)
(Monodelphis domestica)
Mammalia SIVA1 36
  • 56 (a)
(Gallus gallus)
Aves SIVA1 35
  • 58.91 (n)
  • 51.74 (a)
SIVA1 36
  • 49 (a)
(Anolis carolinensis)
Reptilia SIVA1 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia siva1 35
  • 56.12 (n)
  • 49.37 (a)
(Danio rerio)
Actinopterygii siva1 35
  • 52.3 (n)
  • 43.11 (a)
siva1 36
  • 41 (a)
Species with no ortholog for SIVA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIVA1 Gene

Gene Tree for SIVA1 (if available)
Gene Tree for SIVA1 (if available)

Paralogs for SIVA1 Gene

No data available for Paralogs for SIVA1 Gene

Variants for SIVA1 Gene

Sequence variations from dbSNP and Humsavar for SIVA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs14905 -- 104,759,551(+) ACGAG(C/T)GCTCG downstream-variant-500B, utr-variant-3-prime
rs8006310 -- 104,752,139(+) GCGGC(A/G)TGGGG upstream-variant-2KB
rs8006580 -- 104,751,996(+) cgagc(A/G)agggc upstream-variant-2KB
rs1804801 -- 104,756,610(+) CCCAT(A/C)TGGGG reference, missense
rs1804802 -- 104,756,748(+) CCTGT(G/T)TGGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SIVA1 Gene

Variant ID Type Subtype PubMed ID
dgv2008n71 CNV Loss 21882294
dgv2009n71 CNV Loss 21882294
nsv902389 CNV Loss 21882294
nsv470678 CNV Gain 18288195
nsv470677 CNV Loss 18288195
dgv2012n71 CNV Loss 21882294
dgv2013n71 CNV Loss 21882294
nsv517038 CNV Loss 19592680
nsv820230 CNV Gain 19587683
dgv2015n71 CNV Loss 21882294
nsv456455 CNV Loss 19166990
nsv902407 CNV Gain 21882294
nsv827077 CNV Gain 20364138

Variation tolerance for SIVA1 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIVA1 Gene

Disorders for SIVA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SIVA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
scapuloperoneal myopathy
- elite association - COSMIC cancer census association via MalaCards
Search SIVA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SIVA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SIVA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIVA1 Gene

Publications for SIVA1 Gene

  1. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. (PMID: 9177220) Prasad K.V.S. … Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 67
  2. Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva. (PMID: 18330885) Balci-Peynircioglu B. … Gumucio D.L. (J. Cell. Physiol. 2008) 3 23
  3. The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. (PMID: 17653867) Py B. … Benichou S. (Apoptosis 2007) 3 23
  4. Siva-1 and an alternative splice form lacking the death domain, Siva- 2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway. (PMID: 15034012) Py B. … Benichou S. (J. Immunol. 2004) 3 23
  5. The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva. (PMID: 11601913) Henke A. … Munder T. (Virology 2001) 3 23

Products for SIVA1 Gene

Sources for SIVA1 Gene