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SIVA1 Gene

protein-coding   GIFtS: 51
GCID: GC14P105219

SIVA1, Apoptosis-Inducing Factor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SIVA1, Apoptosis-Inducing Factor1 2     Siva-22
CD27BP2 3     Apoptosis Regulatory Protein Siva2
SIVA2 3     CD27-Binding (Siva) Protein2
Siva-12     CD27-Binding Protein3

External Ids:    HGNC: 177121   Entrez Gene: 105722   Ensembl: ENSG000001849907   OMIM: 6055675   UniProtKB: O153043   

Export aliases for SIVA1 gene to outside databases

Previous GC identifers: GC14P104291 GC14P085416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIVA1 Gene:
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the
CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic
tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct
proteins have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIVA1 Gene:
SIVA1 (SIVA1, apoptosis-inducing factor) is a protein-coding gene. Diseases associated with SIVA1 include typhoid fever, and gastroenteritis. GO annotations related to this gene include CD27 receptor binding and virus receptor activity.

UniProtKB/Swiss-Prot: SIVA_HUMAN, O15304
Function: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits
activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis

Gene Wiki entry for SIVA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIVA1 gene promoter:
         AhR   Pax-5   Tal-1   ATF-2   GATA-2   YY1   Arnt   E47   CREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SIVA1 promoter sequence
   Search Chromatin IP Primers for SIVA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIVA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

SIVA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIVA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P105219:  view genomic region     (about GC identifiers)

Start:
105,219,437 bp from pter      End:
105,234,831 bp from pter
Size:
15,395 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SIVA_HUMAN, O15304 (See protein sequence)
Recommended Name: Apoptosis regulatory protein Siva  
Size: 175 amino acids; 18695 Da
Cofactor: Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions
Subunit: Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus
of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2
from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2
Sequence caution: Sequence=AAC51372.1; Type=Erroneous initiation; Sequence=AAD50057.1; Type=Erroneous initiation;
Secondary accessions: Q96P98 Q9UPD6
Alternative splicing: 2 isoforms:  O15304-1   O15304-2   (Mouse isoform 2 has been shown (PubMed:9177220) to have no pro-apoptotic activity. However, human isoform 2 has been shown to be capable of inducing apoptosis (PubMed:15034012))

Explore the universe of human proteins at neXtProt for SIVA1: NX_O15304

Explore proteomics data for SIVA1 at MOPED

Post-translational modifications: 

  • Phosphorylated by ABL2/ARG in response to oxidative stress1
  • Ubiquitination2 at Lys17, Lys41, Lys124
  • Modification sites at PhosphoSitePlus

  • See SIVA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006418.2  NP_068355.1  

    ENSEMBL proteins: 
     ENSP00000329213   ENSP00000329447   ENSP00000451570   ENSP00000451427   ENSP00000451823  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022773 Siva_cd27-bd

    Graphical View of Domain Structure for InterPro Entry O15304

    ProtoNet protein and cluster: O15304

    1 Blocks protein domain: IPB008842 Cd27 binding


    SIVA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIVA_HUMAN, O15304
    Function: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits
    activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity ISS--
    GO:0005175CD27 receptor binding IPI16683188
    GO:0005515protein binding IPI12011449
    GO:0008270zinc ion binding IDA16683188
    GO:0046872metal ion binding IEA--
         
    SIVA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIVA1:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIVA1
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    miRTarBase miRNAs that target SIVA1:
    hsa-mir-340-5p (MIRT019564)

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    4 qRT-PCR Assays for microRNAs that regulate SIVA1:
    hsa-miR-142-5p hsa-miR-19b hsa-miR-19a hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSIVA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIVA_HUMAN, O15304: Cytoplasm. Nucleus. Note=In the nucleus, accumulates in dot-like structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3
    extracellular1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005654nucleoplasm IDA15034012
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion IDA12011449

    SIVA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIVA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis Signaling Pathways
    Apoptosis and survival Apoptotic TNF family pathways0.35
    2Lymphocyte Signaling
    Lymphocyte Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIVA1
        CD27 Pathway
    GITR Pathway

    2 Cell Signaling Technology (CST) Pathways for SIVA1
        Apoptosis and Autophagy
    Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for SIVA1
        Apoptosis and survival Apoptotic TNF-family pathways




    SIVA1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIVA1
    Interactions:

        GeneGlobe Interaction Network for SIVA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for SIVA1 (O153041, 2, 3 ENSP000003292134) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL2P104151, 3, ENSP000003296234EBI-520756,EBI-77694 I2D: score=1 STRING: ENSP00000329623
    MYZAPP0CAP12, 3MINT-65204 I2D: score=3 
    PXMP2Q9NR771, 3EBI-520756,EBI-1392944 I2D: score=2 
    BCL2L1Q078171, 3, ENSP000003025644EBI-520756,EBI-78035 I2D: score=3 STRING: ENSP00000302564
    CD27P268421, 3, ENSP000002665574EBI-520756,EBI-520729 I2D: score=5 STRING: ENSP00000266557
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006924activation-induced cell death of T cells IDA16491128
    GO:0009615response to virus ISS--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA16491128

    SIVA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIVA1 (SIVA)

    UniProtKB/Swiss-Prot: SIVA_HUMAN, O15304
    Pharmaceutical: Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated
    apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIVA1 gene (2 alternative transcripts): 
    NM_006427.3  NM_021709.2  

    Unigene Cluster for SIVA1:

    SIVA1, apoptosis-inducing factor
    Hs.112058  [show with all ESTs]
    Unigene Representative Sequence: AK128704
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329967(uc001yph.3 uc001ypi.3) ENST00000535554(uc010tyj.1)
    ENST00000347067 ENST00000553810 ENST00000553819 ENST00000554013 ENST00000556431(uc001ypg.1)
    ENST00000556195
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    4 qRT-PCR Assays for microRNAs that regulate SIVA1:
    hsa-miR-142-5p hsa-miR-19b hsa-miR-19a hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidSIVA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SIVA1
      QuantiFast Probe-based Assays in human, mouse, rat SIVA1

    Additional mRNA sequence: 

    AF033111.1 AF401214.1 AK095949.1 AK124078.1 AK128704.1 AK223332.1 AK300415.1 AK316457.1 
    AK316550.1 BC034562.1 

    8 DOTS entries:

    DT.217007  DT.101956883  DT.100792266  DT.101969811  DT.40121780  DT.40284918  DT.95279965  DT.95140185 

    Selected AceView cDNA sequences (see all 268):

    AW250652 CF552512 AI560326 NM_006427 AI369273 BE792641 BM310878 BM919839 
    BU846436 BQ670026 NM_021709 F31352 AI802676 AW170666 AA628332 BU162880 
    AW575647 BQ943607 BG683095 CA432072 BC034562 AA953323 BQ013306 AW025365 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SIVA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:              -                 -               
    SP2:              -                                 
    SP3:              -     -           -               
    SP4:                                                


    ECgene alternative splicing isoforms for SIVA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIVA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTATTTTG
    SIVA1 Expression
    About this image

    SIVA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIVA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112058

    UniProtKB/Swiss-Prot: SIVA_HUMAN, O15304
    Tissue specificity: Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen
    and less in colon

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SIVA1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Siva11 , 5 SIVA1, apoptosis-inducing factor1, 5 73.95(n)1
    71.26(a)1
      12 (61.20 cM)5
    309541  NM_013929.21  NP_038957.21 
     1126448285 
    chicken
    (Gallus gallus)
    Aves SIVA11 SIVA1, apoptosis-inducing factor 58.91(n)
    51.74(a)
      423493  NM_001277535.1  NP_001264464.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIVA16
    SIVA1, apoptosis-inducing factor
    46(a)
    1 ↔ 1
    1(3684322-3692289)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia siva11 SIVA1, apoptosis-inducing factor 56.12(n)
    49.37(a)
      733962  NM_001045673.1  NP_001039138.1 
    zebrafish
    (Danio rerio)
    Actinopterygii siva11 SIVA1, apoptosis-inducing factor 52.3(n)
    43.11(a)
      571845  XM_695476.6  XP_700568.6 


    ENSEMBL Gene Tree for SIVA1 (if available)
    TreeFam Gene Tree for SIVA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIVA1 (see all 222)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349920741,2
    C,F--85420182(+) CACACAT/-GTGTG 2 -- int14Minor allele frequency- -:0.25NA CSA 12
    rs1434024831,2
    C--85420683(+) GACAC-/ATGTGGA 2 -- int10--------
    rs1999207961,2
    C--85420684(-) TCCACA/GTNNNN 2 -- int10--------
    rs1807691851,2
    --86208643(+) ACCGAC/TTGGTG 2 -- us2k10--------
    rs1842940551,2
    --86208862(+) GTGCCA/GCGGAG 2 -- us2k10--------
    rs80114611,2
    C,F,A--86208882(+) gcgcaG/Agagcc 2 -- us2k16Minor allele frequency- A:0.34NA CSA WA EA 364
    rs80117791,2
    C,F,A--86208943(+) cctcgT/Cgggga 2 -- us2k13Minor allele frequency- C:0.33NA CSA 6
    rs1155203751,2
    F--86208990(+) CGGCGG/AGCCGG 2 -- us2k11Minor allele frequency- A:0.26WA 118
    rs1885884181,2
    --86209012(+) GACCCA/GGCGCA 2 -- us2k10--------
    rs1817484381,2
    --86209023(+) TCCTCC/TGCAGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIVA1 (105219437 - 105234831 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIVA1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2013n71CNV Loss21882294
    dgv2008n71CNV Loss21882294
    dgv2015n71CNV Loss21882294
    nsv517038CNV Loss19592680
    dgv2009n71CNV Loss21882294
    dgv2012n71CNV Loss21882294
    nsv470677CNV Loss18288195
    nsv456455CNV Loss19166990
    nsv902389CNV Loss21882294
    nsv902407CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605567    OMIM disorders: --

    9 diseases for SIVA1:    
    About MalaCards
    typhoid fever    gastroenteritis    familial mediterranean fever    influenza
    ischemia    hiv-1    breast cancer    neuronitis
    prostatitis


    SIVA1 for disorders           About GeneDecksing


    Export disorders for SIVA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIVA1 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with SIVA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. (PubMed id 9177220)1, 2, 3 Prasad K.V.S....Schlossman S.F. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva. (PubMed id 11601913)1, 2, 9 Henke A.... Munder T. (Virology 2001)
    3. Siva-1 and an alternative splice form lacking the death domain, Siva- 2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway. (PubMed id 15034012)1, 2, 9 Py B.... Benichou S. (J. Immunol. 2004)
    4. Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva. (PubMed id 10756043)1, 2, 9 Henke A.... Munder T. (J. Virol. 2000)
    5. The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22. (PubMed id 16683188)1, 2 Nestler M....Munder T. (Mol. Cell. Biochem. 2006)
    6. Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). (PubMed id 16491128)1, 2 Gudi R.... Prasad K.V.S. (Oncogene 2006)
    7. Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2. (PubMed id 15958577)1, 2 Chu F.... Kanteti P.V.S. (Cancer Res. 2005)
    8. The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis. (PubMed id 14739602)1, 2 Chu F....Prasad K.V.S. (Apoptosis 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. (PubMed id 12011449)1, 2 Xue L.... Prasad K.V.S. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10572 HGNC: 17712 AceView: SIVA Ensembl:ENSG00000184990 euGenes: HUgn10572
    ECgene: SIVA1 H-InvDB: SIVA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIVA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIVA1 gene:
    Search GeneIP for patents involving SIVA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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