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SIT1 Gene

protein-coding   GIFtS: 54
GCID: GC09M035640

Signaling Threshold Regulating Transmembrane Adaptor 1

(Previous name: suppression inducing transmembrane adaptor 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signaling Threshold Regulating Transmembrane Adaptor 11 2     SHP2-Interacting Transmembrane Adapter Protein2 3
SIT2 3 5     SIT-R2
Suppression Inducing Transmembrane Adaptor 11 2     SHP-2 Interacting Transmembrane Adaptor Protein2
SHP2 Interacting Transmembrane Adaptor1 2     SHP2-Interacting Transmembrane Adaptor Protein2
Suppression-Inducing Transmembrane Adapter 12 3     Signaling Threshold-Regulating Transmembrane Adapter 12
gp30/402 3     

External Ids:    HGNC: 177101   Entrez Gene: 272402   Ensembl: ENSG000001370787   OMIM: 6049645   UniProtKB: Q9Y3P83   

Export aliases for SIT1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SIT1 Gene:
SIT1 (signaling threshold regulating transmembrane adaptor 1) is a protein-coding gene. Diseases associated with SIT1 include multidrug-resistant tuberculosis, and tuberculosis. GO annotations related to this gene include kinase binding and SH2 domain binding.

UniProtKB/Swiss-Prot: SIT1_HUMAN, Q9Y3P8
Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive
selection of T-cells

Gene Wiki entry for SIT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIT1 gene promoter:
         IRF-2   Sp1   p300   Lmo2   LCR-F1   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIT1 promoter sequence
   Search Chromatin IP Primers for SIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13-p12   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13-p12

SIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIT1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035640:  view genomic region     (about GC identifiers)

Start:
35,649,292 bp from pter      End:
35,650,947 bp from pter
Size:
1,656 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIT1_HUMAN, Q9Y3P8 (See protein sequence)
Recommended Name: Signaling threshold-regulating transmembrane adapter 1 precursor  
Size: 196 amino acids; 21126 Da
Subunit: Homodimer; disulfide-linked. When phosphorylated, interacts with PTPN11/SHP2, GRB2 and CSK
Caution: In contrast to its orthologs it harbors a signal sequence
Secondary accessions: B2RBP9

Explore the universe of human proteins at neXtProt for SIT1: NX_Q9Y3P8

Explore proteomics data for SIT1 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11,
    GRB2 and CSK1
  • Ubiquitination2 at Lys147
  • Glycosylation2 at Asn26
  • Modification sites at PhosphoSitePlus

  • See SIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055265.1  
    ENSEMBL proteins: 
     ENSP00000259608  

    SIT1 Human Recombinant Protein Products:

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    SIT1 Assay Products:

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    Cloud-Clone Corp. ELISAs for SIT1
    Cloud-Clone Corp. CLIAs for SIT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9Y3P8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIT1_HUMAN, Q9Y3P8
    Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive
    selection of T-cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10209036
    GO:0019900kinase binding IPI10209036
    GO:0042169SH2 domain binding TAS11433379
         
    SIT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SIT1:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sit1):
     hematopoietic system  immune system 

    SIT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sit1tm1Lsmn for SIT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIT1

    miRNA
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    Block miRNA regulation of human, mouse, rat SIT1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SIT1:
    hsa-miR-92a-1* hsa-miR-3150b-3p hsa-miR-4290 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidSIT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIT1
    Predesigned siRNA for gene silencing in human, mouse, rat SIT1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for SIT1

    Clone
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    OriGene clones in human, mouse for SIT1 (see all 5)
    OriGene ORF clones in mouse, rat for SIT1
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    GenScript: all cDNA clones in your preferred vector: SIT1 (NM_014450)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIT1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIT1_HUMAN, Q9Y3P8: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol3
    mitochondrion2
    extracellular1
    lysosome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IDA10209036
    GO:0005887integral component of plasma membrane TAS11433379
    GO:0070062extracellular vesicular exosome IDA--

    SIT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SIT1
        TCR Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIT1
    Interactions:

        GeneGlobe Interaction Network for SIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SIT1 (Q9Y3P82, 3 ENSP000002596084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-8034949 MINT-8034964 I2D: score=4 STRING: ENSP00000340944
    FYNP062413, ENSP000003576564I2D: score=3 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    SYKP434053, ENSP000003648984I2D: score=3 STRING: ENSP00000364898
    ZAP70P434033, ENSP000002649724I2D: score=3 STRING: ENSP00000264972
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0007165signal transduction TAS10209036
    GO:0050863regulation of T cell activation IDA10209036

    SIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SIT1

    1 Novoseek inferred chemical compound relationship for SIT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37 4 11433379 (3)



    SIT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIT1 gene: 
    NM_014450.2  

    Unigene Cluster for SIT1:

    Signaling threshold regulating transmembrane adaptor 1
    Hs.88012  [show with all ESTs]
    Unigene Representative Sequence: BQ056568
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259608(uc003zxe.1) ENST00000486859 ENST00000474403
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SIT1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SIT1:
    hsa-miR-92a-1* hsa-miR-3150b-3p hsa-miR-4290 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidSIT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIT1
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    GenScript: all cDNA clones in your preferred vector: SIT1 (NM_014450)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIT1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SIT1
      QuantiTect SYBR Green Assays in human, mouse, rat SIT1
      QuantiFast Probe-based Assays in human, mouse, rat SIT1

    Additional mRNA sequence: 

    AJ010059.1 AK314758.1 BC102029.1 BC104491.1 BC107484.1 JQ924063.1 

    3 DOTS entries:

    DT.109933  DT.95159963  DT.102822261 

    Selected AceView cDNA sequences (see all 158):

    AA380418 BQ054614 CA488943 BC038673 BE728707 AA421195 AA459295 AW135205 
    AA714519 AW404968 BQ066178 BQ056724 AA430511 BE267550 AI732738 BM680405 
    BF796667 BE018581 AW674851 CR616792 BF436061 AY390226 AY390225 BC033666 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SIT1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                            -               
    SP2:                    -                       -               
    SP3:                                                            
    SP4:                          -                                 


    ECgene alternative splicing isoforms for SIT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTTCCC
    SIT1 Expression
    About this image


    SIT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
     
     Lymph (Hematopoietic System)
    SIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.88012

    UniProtKB/Swiss-Prot: SIT1_HUMAN, Q9Y3P8
    Tissue specificity: Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center
    B-cells (at protein level). Expressed in T- and B-cell lymphoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SIT1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sit11 , 5 suppression inducing transmembrane adaptor 11, 5 83.52(n)1
    78.41(a)1
      4 (23.04 cM)5
    543901  NM_019436.31  NP_062309.21 
     434820815 


    ENSEMBL Gene Tree for SIT1 (if available)
    TreeFam Gene Tree for SIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIT1 gene
    1 SIMAP similar gene for SIT1 using alignment to 1 protein entry:     SIT1_HUMAN:
    SIT-R

    SIT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIT1 (see all 118)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1511042111,2
    --35648835(+) TAGTGA/CTGGGG 1 -- ds50010--------
    rs13393751,2
    C,F,O,A,H--35648935(+) ACAGAC/GGGAGG 1 -- ds500124Minor allele frequency- N:0.00EA NA NS CSA WA 1452
    rs31380831,2
    C,F,A,H--35648950(-) AGTCCC/TCCAAT 1 -- ds500121Minor allele frequency- T:0.49NS EA NA WA CSA 2343
    rs1498159561,2
    --35649104(+) CAACAG/TCAGCT 1 -- ds50010--------
    rs38188631,2
    C,F--35649150(+) ACCTCT/GGCACT 1 -- ds50013Minor allele frequency- G:0.23EA WA 1740
    rs31380821,2
    C,F,H--35649216(-) TGCACG/AGAGCT 1 -- ds500116Minor allele frequency- A:0.10NS EA NA 2022
    rs1878755951,2
    --35649239(+) CACACC/TCCCAT 1 -- ds50010--------
    rs748578091,2
    F--35649249(+) TCTGCA/GGGGCC 1 -- ds50012Minor allele frequency- G:0.06NA EA 240
    rs1925533641,2
    --35649335(+) GACAGA/TGACAG 1 -- ut310--------
    rs1134435051,2
    C--35649611(+) GGGGGA/C/GTAAGA 2 -- ut311CSA 1

    HapMap Linkage Disequilibrium report for SIT1 (35649292 - 35650947 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SIT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8168n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIT1
    DNA2.0 Custom Variant and Variant Library Synthesis for SIT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604964    OMIM disorders: --

    4 diseases for SIT1:    
    About MalaCards
    multidrug-resistant tuberculosis    tuberculosis    b-cell lymphomas    alzheimer's disease


    SIT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIT1
    Human Genome Epidemiology (HuGE) Navigator: SIT1 (1 document)

    Export disorders for SIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIT1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with SIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation. (PubMed id 10209036)1, 2, 3, 9 Marie-Cardine A.... Schraven B. (J. Exp. Med. 1999)
    2. Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT). (PubMed id 11491537)1, 2, 3, 9 Huebener C.... Bruyns E. (Immunogenetics 2001)
    3. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). (PubMed id 11433379)1, 2, 9 Pfrepper K.-I.... Schraven B. (Eur. J. Immunol. 2001)
    4. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    5. Transmembrane adaptor molecules: a new category of lymphoid-cell markers. (PubMed id 16160011)1, 2 Tedoldi S....Horejsi V. (Blood 2006)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27240 HGNC: 17710 AceView: SITandC9orf100 Ensembl:ENSG00000137078 euGenes: HUgn27240
    ECgene: SIT1 H-InvDB: SIT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIT1 gene:
    Search GeneIP for patents involving SIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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