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Aliases for SIT1 Gene

Aliases for SIT1 Gene

  • Signaling Threshold Regulating Transmembrane Adaptor 1 2 3
  • SIT 3 4 6
  • SHP2-Interacting Transmembrane Adapter Protein 3 4
  • Suppression Inducing Transmembrane Adaptor 1 2 3
  • Suppression-Inducing Transmembrane Adapter 1 3 4
  • SHP2 Interacting Transmembrane Adaptor 2 3
  • Gp30/40 3 4
  • Signaling Threshold-Regulating Transmembrane Adapter 1 3
  • SHP-2 Interacting Transmembrane Adaptor Protein 3
  • SHP2-Interacting Transmembrane Adaptor Protein 3
  • SIT-R 3

External Ids for SIT1 Gene

Summaries for SIT1 Gene

GeneCards Summary for SIT1 Gene

SIT1 (Signaling Threshold Regulating Transmembrane Adaptor 1) is a Protein Coding gene. Among its related pathways are TCR Signaling (Qiagen). GO annotations related to this gene include kinase binding and SH2 domain binding.

UniProtKB/Swiss-Prot for SIT1 Gene

  • Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.

Gene Wiki entry for SIT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIT1 Gene

Genomics for SIT1 Gene

Regulatory Elements for SIT1 Gene

Genomic Location for SIT1 Gene

35,649,295 bp from pter
35,650,950 bp from pter
1,656 bases
Minus strand

Genomic View for SIT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIT1 Gene

Proteins for SIT1 Gene

  • Protein details for SIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signaling threshold-regulating transmembrane adapter 1
    Protein Accession:
    Secondary Accessions:
    • B2RBP9

    Protein attributes for SIT1 Gene

    196 amino acids
    Molecular mass:
    21126 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. When phosphorylated, interacts with PTPN11/SHP2, GRB2 and CSK.

neXtProt entry for SIT1 Gene

Proteomics data for SIT1 Gene at MOPED

Post-translational modifications for SIT1 Gene

  • Phosphorylated on tyrosines by LCK, FYN or ZAP70 upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK.
  • Ubiquitination at Lys147
  • Glycosylation at Asn26
  • Modification sites at PhosphoSitePlus

Other Protein References for SIT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIT1 Gene

Domains for SIT1 Gene

Protein Domains for SIT1 Gene


Suggested Antigen Peptide Sequences for SIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIT1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SIT1 Gene

Function for SIT1 Gene

Molecular function for SIT1 Gene

UniProtKB/Swiss-Prot Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.

Gene Ontology (GO) - Molecular Function for SIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10209036
GO:0019900 kinase binding IPI 10209036
GO:0042169 SH2 domain binding TAS 11433379
genes like me logo Genes that share ontologies with SIT1: view

Phenotypes for SIT1 Gene

MGI mutant phenotypes for SIT1:
inferred from 1 alleles
GenomeRNAi human phenotypes for SIT1:
genes like me logo Genes that share phenotypes with SIT1: view

Animal Models for SIT1 Gene

MGI Knock Outs for SIT1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SIT1 Gene

Localization for SIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIT1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for SIT1 Gene COMPARTMENTS Subcellular localization image for SIT1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 10209036
GO:0005887 integral component of plasma membrane TAS 11433379
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SIT1: view

Pathways for SIT1 Gene

SuperPathways for SIT1 Gene

Superpath Contained pathways
1 TCR Signaling (Qiagen)
genes like me logo Genes that share pathways with SIT1: view

Pathways by source for SIT1 Gene

1 Qiagen pathway for SIT1 Gene

Gene Ontology (GO) - Biological Process for SIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0007165 signal transduction TAS 10209036
GO:0050863 regulation of T cell activation IDA 10209036
genes like me logo Genes that share ontologies with SIT1: view

Compounds for SIT1 Gene

(1) Novoseek inferred chemical compound relationships for SIT1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 37 3
genes like me logo Genes that share compounds with SIT1: view

Transcripts for SIT1 Gene

Unigene Clusters for SIT1 Gene

Signaling threshold regulating transmembrane adaptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIT1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SIT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP4: -

Relevant External Links for SIT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIT1 Gene

mRNA expression in normal human tissues for SIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIT1 Gene

This gene is overexpressed in Whole Blood (11.2), Spleen (8.4), and Small Intestine - Terminal Ileum (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIT1 Gene

SOURCE GeneReport for Unigene cluster for SIT1 Gene Hs.88012

mRNA Expression by UniProt/SwissProt for SIT1 Gene

Tissue specificity: Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma.
genes like me logo Genes that share expressions with SIT1: view

In Situ Assay Products

Orthologs for SIT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIT1 35
  • 99.32 (n)
  • 100 (a)
SIT1 36
  • 100 (a)
(Bos Taurus)
Mammalia SIT1 35
  • 84.35 (n)
  • 80.11 (a)
SIT1 36
  • 69 (a)
(Canis familiaris)
Mammalia SIT1 35
  • 85.66 (n)
  • 82.12 (a)
SIT1 36
  • 81 (a)
(Mus musculus)
Mammalia Sit1 35
  • 83.52 (n)
  • 78.41 (a)
Sit1 16
Sit1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SIT1 36
  • 39 (a)
(Rattus norvegicus)
Mammalia Sit1 35
  • 80.87 (n)
  • 78.41 (a)
Species with no ortholog for SIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIT1 Gene

Gene Tree for SIT1 (if available)
Gene Tree for SIT1 (if available)

Paralogs for SIT1 Gene

Selected SIMAP similar genes for SIT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SIT1: view

No data available for Paralogs for SIT1 Gene

Variants for SIT1 Gene

Sequence variations from dbSNP and Humsavar for SIT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1140679 -- 35,650,768(-) CACGG(A/T)TCTAC reference, missense
rs1339375 -- 35,648,938(+) ACAGA(C/G/T)GGAGG downstream-variant-500B
rs2297880 -- 35,650,461(+) TAAGA(A/G)AGAAC intron-variant
rs3138080 -- 35,650,211(-) CAGCA(A/G)GATCC synonymous-codon, reference
rs3138081 -- 35,649,810(-) GCCCC(A/T)GCCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIT1 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294

Relevant External Links for SIT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIT1 Gene

Disorders for SIT1 Gene

Relevant External Links for SIT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SIT1: view

No data available for UniProtKB/Swiss-Prot for SIT1 Gene

Publications for SIT1 Gene

  1. Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT). (PMID: 11491537) Huebener C. … Bruyns E. (Immunogenetics 2001) 2 3 4 23
  2. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation. (PMID: 10209036) Marie-Cardine A. … Schraven B. (J. Exp. Med. 1999) 2 3 4 23
  3. Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). (PMID: 11433379) Pfrepper K.-I. … Schraven B. (Eur. J. Immunol. 2001) 3 4 23
  4. Transmembrane adaptor molecules: a new category of lymphoid-cell markers. (PMID: 16160011) Tedoldi S. … Horejsi V. (Blood 2006) 3 4
  5. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 48

Products for SIT1 Gene

Sources for SIT1 Gene

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