SIRT7 Gene
protein-coding GIFtS: 59
GCID: GC17M079869
|
|
sirtuin 7(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)
| |
Aliases
for SIRT7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sirtuin 71 2 | | NAD-Dependent Deacetylase Sirtuin-72 | | SIR2L72 3 5 | | NAD-Dependent Protein Deacetylase Sirtuin-72 | | Regulatory Protein SIR2 Homolog 72 3 | | Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 72 | | SIR2-Like Protein 72 3 | | Sir2-Related Protein Type 72 | | Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae)1 | | Sirtuin Type 72 | | Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 71 | | EC 3.5.1.-3 |
Export aliases for SIRT7 gene to outside databasesPrevious GC identifers: GC17M079361 GC17M9I0172 GC17M080405 GC17M9I0548 GC17M9I7463 GC17M077464 GC17M077465 GC17M075271 |
Summaries
for SIRT7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIRT7:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of thesirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of humansirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencingand suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatoryproteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of thesirtuin family. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8Function: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18'(H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac,directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genesand has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor.Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintainthe transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenictransformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac atpromoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis:promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcriptionactivity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such dataneed additional confirmation
 summary
for SIRT7: Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.
Gene Wiki entry for SIRT7
|
Genomic Views
for SIRT7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIRT7 gene promoter:
HOXA9 TBP E2F AP-1 ATF-2 MyoD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIRT7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3SIRT7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M079869: view genomic region
(about GC identifiers)
Start:
|
79,869,815 bp from pter |
End:
|
79,879,199 bp from pter |
Size:
|
9,385 bases |
Orientation:
|
minus strand |
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Proteins
for SIRT7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8 (See
protein sequence)Recommended Name: NAD-dependent protein deacetylase sirtuin-7 Size: 400 amino acids; 44898 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex, such asMYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters for H3K18Acdeacetylation. Interacts with histone H2A and/or histone H2B
Subcellular location: Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm.Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizerregions during mitosis
Miscellaneous: Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas
Caution: Was originally (PubMed:11953824) termed SIR-T8/SIRT8. This was later retracted (PubMed:12454780). See alsoPubMed:12454781
Sequence caution: Sequence=CAB70848.2; Type=Miscellaneous discrepancy;
Secondary accessions: A8K2K0 B3KSU8 Q3MIK4 Q9NSZ6 Q9NUS6Alternative splicing: 3 isoforms: Q9NRC8-1 Q9NRC8-2 Q9NRC8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIRT7: NX_Q9NRC8
Post-translational modifications:
Phosphorylated during mitosis (Probable)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRC8
SIRT7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057622.1
ENSEMBL proteins: ENSP00000329466 ENSP00000458737 ENSP00000458897 ENSP00000461044 ENSP00000459524
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SIRT7 for ontologies About GeneDecksing
SIRT7 Antibody Products:
Assay Products for SIRT7: |
Protein
Domains /
Families
for SIRT7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIRT7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRC8ProtoNet protein and cluster: Q9NRC8 1 Blocks protein family: IPB003000 Silent information regulator protein Sir2
UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8Similarity: Belongs to the sirtuin family. Class IV subfamilySimilarity: Contains 1 deacetylase sirtuin-type domain |
Function
for SIRT7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8Function: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18'(H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac,directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genesand has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor.Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintainthe transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenictransformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac atpromoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis:promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcriptionactivity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such dataneed additional confirmationCatalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a proteinEnzyme Number (IUBMB): EC 3.5.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SIRT7 (NM_016538) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRT7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT7 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
SIRT7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SIRT7:
Animal Models:
Mouse knock-out Sirt7tm1Evbo for SIRT7
12 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Sirt7):
SIRT7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SIRT7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | NAD metabolism | | | 2 | Non-homologous end-joining | | | 3 | Signaling events mediated by HDAC Class I | | | 4 | Signaling events mediated by HDAC Class III | | | 5 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for SIRT7
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT7
1 
Cell Signaling Technology (CST) Pathway for SIRT7
2  GeneGo (Thomson Reuters) Pathways for SIRT7
2  BioSystems Pathways for SIRT7
SIRT7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIRT7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/677 Interacting proteins for SIRT7 (Q9NRC82, 3 ENSP000003294664) via UniProtKB, MINT, STRING, and/or I2D (see all 677)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SIRT7 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIRT7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for SIRT7 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Sirtinol | Selective sirtuin family deacetylase inhibitor | [410536-97-9] | | Splitomicin | Sir2p inhibitor | [5690-03-9] |
1 HMDB Compound for SIRT7 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- |
Search CenterWatch for drugs/clinical trials and news about SIRT7 / SIR7
|
Transcripts
for SIRT7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIRT7 gene: NM_016538.2 Unigene Cluster for SIRT7: Sirtuin 7 Hs.514636 [show with all ESTs]Unigene Representative Sequence: AK13143718/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000574992 ENST00000572976 ENST00000571832 ENST00000536038 ENST00000328666(uc002kcj.2)
ENST00000576004 ENST00000576971 ENST00000574153 ENST00000576156 ENST00000571233
ENST00000572902 ENST00000572350 ENST00000577065 ENST00000574495 ENST00000573367
ENST00000571915 ENST00000575360 ENST00000575244
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIRT7 (NM_016538) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRT7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT7 |
Additional cDNA sequence: AF233395.1 AK094326.1 AK131437.1 AK290265.1 AL137626.1 BC017305.2 BC101791.1 BC101793.1 20 DOTS entries: DT.95287654 DT.454662 DT.101959177 DT.95205939 DT.100821692 DT.120932852 DT.120932841 DT.92428690 DT.95205925 DT.120932876 DT.91936508 DT.95205933 DT.120932859 DT.120932867 DT.95205941 DT.100821687 DT.100821691 DT.91816305 DT.99987651 DT.446479 24/669 AceView cDNA sequences (see all 669): BU738568 BF061745 BF725990 BI793087 BQ428131 AI339910 BM801285 AI254743 AI281178 BF001964 BM055412 CA307028 AI833017 BQ017626 CF145826 CA424339 BX427058 BU186830 BM967165 AA948414 BM719511 BQ001079 CR617660 AI872048
GeneLoc Exon Structure
|
Expression
for SIRT7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIRT7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGAGCTGG
About this image
See SIRT7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRT7
SOURCE GeneReport for Unigene cluster: Hs.514636
SABiosciences Custom PCR Arrays for SIRT7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRT7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIRT7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRT7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT7 |
Orthologs
for SIRT7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SIRT7 gene from 7/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PCYT21 |
phosphate cytidylyltransferase 2, ethanolamine |
73.25(n)
77.22(a) |
|
422093 NM_001031106.1 NP_001026277.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SIRT76SIRT56 |
-- |
76(a)17(a) |
1 ↔ 1possible ortholog |
2(118482249-118490171) 4(57071927-57080042) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.157802 |
Xenopus laevis transcribed sequence with weak similarity more |
75.36(n) |
|
BX842913.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7961351 |
novel protein similar to vertebratesirtuin (silent more |
63.08(n)
66.67(a) |
|
796135 XM_001336402.3 XP_001336438.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG113053
Sirt71 |
CG11305-PA1 |
52(a)3
55.68(n)1
51.1(a)1 |
|
98F63
434331 NM_143407.21 NP_651664.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
sir-2.46 |
yeast SIR related family member (sir-2.4) |
21(a) |
1 ↔ 1 |
I(5990741-5992670) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
cobB6 |
deacetylase of acs and cheY, regulates chemotaxis |
20(a) |
possible ortholog |
Chromosome(1178854-1179582) |
ENSEMBL Gene Tree for SIRT7 (if available)
TreeFam Gene Tree for SIRT7 (if available) |
Paralogs
for SIRT7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIRT7 gene
- SIRT62
1 SIMAP similar gene for SIRT7 using alignment to 5 protein entries: SIR7_HUMAN (see all proteins):SIRT6
SIRT7 for paralogs About GeneDecksing
|
Genomic Variants
for SIRT7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIRT7 (79869815 - 79879199 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SIRT7
6 CNVs: 23319 30036 5042 7175 73078 5041 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRT7 |
|
Disorders
/ Diseases
for SIRT7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIRT7 for disorders About GeneDecksing
OMIM gene information: 606212
OMIM disorders: --
6  diseases for SIRT7: About MalaCardsthyroiditis thyroid carcinoma thyroid cancer breast cancer
adenoma carcinoma
Export disorders for SIRT7 gene to outside databases
|
Publications
for SIRT7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIRT7 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with SIRT7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PubMed id 10873683)1, 2, 3, 9 Frye R.A. (2000)
- Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PubMed id 16618798)1, 2, 3 Ford E....Guarente L. (2006)
- Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2, 9 Michishita E.... Horikawa I. (2005)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1, 2 Tsai Y.C....Cristea I.M. (2012)
- SIRT7 links H3K18 deacetylation to maintenance of onco genic transformation. (PubMed id 22722849)1, 2 Barber M.F....Chua K.F. (2012)
- Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. (PubMed id 19174463)1, 2 Grob A....Sirri V. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. (PubMed id 11953824)1, 2 de Nigris F.... Fusco A. (2002)
- Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. (PubMed id 12454780)1, 2 De Nigris F....Fusco A. (2002)
|
External Searches for SIRT7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SIRT7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIRT7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIRT7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for SIRT7 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SIRT7 gene:
Search GeneIP for patents involving SIRT7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SIRT7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SIRT7 | | OriGene shRNA RFP for SIRT7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRT7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRT7 | | | OriGene Protein Over-expression Lysate for SIRT7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIRT7 | | OriGene 3'-UTR Clone for SIRT7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIRT7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIRT7 | | OriGene Custom Protein Services for SIRT7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIRT7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRT7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRT7 |
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| | Antibodies & Assays for SIRT7 |
| | | | Tocris compounds for SIRT7 |
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 | | | SIRT7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT7 |
|  |  |  | | | | ThermoFisher Antibody for SIRT7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT7 |
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