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Aliases for SIRT7 Gene

Aliases for SIRT7 Gene

  • Sirtuin 7 2 3 5
  • Regulatory Protein SIR2 Homolog 7 3 4
  • SIR2-Like Protein 7 3 4
  • SIR2L7 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 7 2
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 7 3
  • NAD-Dependent Deacetylase Sirtuin-7 3
  • Sir2-Related Protein Type 7 3
  • Sirtuin Type 7 3
  • EC 3.5.1.- 4

External Ids for SIRT7 Gene

Previous GeneCards Identifiers for SIRT7 Gene

  • GC17M079361
  • GC17M9I0172
  • GC17M080405
  • GC17M9I0548
  • GC17M9I7463
  • GC17M077464
  • GC17M077465
  • GC17M079869
  • GC17M075271

Summaries for SIRT7 Gene

Entrez Gene Summary for SIRT7 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT7 Gene

SIRT7 (Sirtuin 7) is a Protein Coding gene. Among its related pathways are p53 Signaling and Signaling events mediated by HDAC Class I. GO annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K18 specific). An important paralog of this gene is SIRT6.

UniProtKB/Swiss-Prot for SIRT7 Gene

  • NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Tocris Summary for SIRT7 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT7 Gene

Genomics for SIRT7 Gene

Regulatory Elements for SIRT7 Gene

Enhancers for SIRT7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SIRT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SIRT7 Gene

Chromosome:
17
Start:
81,911,939 bp from pter
End:
81,921,323 bp from pter
Size:
9,385 bases
Orientation:
Minus strand

Genomic View for SIRT7 Gene

Genes around SIRT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT7 Gene

Proteins for SIRT7 Gene

  • Protein details for SIRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC8-SIR7_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-7
    Protein Accession:
    Q9NRC8
    Secondary Accessions:
    • A8K2K0
    • B3KSU8
    • Q3MIK4
    • Q9NSZ6
    • Q9NUS6

    Protein attributes for SIRT7 Gene

    Size:
    400 amino acids
    Molecular mass:
    44898 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation. Interacts with histone H2A and/or histone H2B.
    Miscellaneous:
    • Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas.
    SequenceCaution:
    • Sequence=CAB70848.2; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Alternative splice isoforms for SIRT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT7 Gene

Proteomics data for SIRT7 Gene at MOPED

Post-translational modifications for SIRT7 Gene

Other Protein References for SIRT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIRT7 (SIRT7)

No data available for DME Specific Peptides for SIRT7 Gene

Domains & Families for SIRT7 Gene

Gene Families for SIRT7 Gene

Suggested Antigen Peptide Sequences for SIRT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRC8

UniProtKB/Swiss-Prot:

SIR7_HUMAN :
  • Contains 1 deacetylase sirtuin-type domain.
  • Belongs to the sirtuin family. Class IV subfamily.
Domain:
  • Contains 1 deacetylase sirtuin-type domain.
Family:
  • Belongs to the sirtuin family. Class IV subfamily.
genes like me logo Genes that share domains with SIRT7: view

Function for SIRT7 Gene

Molecular function for SIRT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Enzyme Numbers (IUBMB) for SIRT7 Gene

Gene Ontology (GO) - Molecular Function for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22722849
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific) IDA 22722849
genes like me logo Genes that share ontologies with SIRT7: view
genes like me logo Genes that share phenotypes with SIRT7: view

Animal Models for SIRT7 Gene

MGI Knock Outs for SIRT7:

Animal Model Products

miRNA for SIRT7 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT7 Gene

Localization for SIRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT7 Gene

Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRT7 Gene COMPARTMENTS Subcellular localization image for SIRT7 gene
Compartment Confidence
nucleus 5
mitochondrion 3

No data available for Gene Ontology (GO) - Cellular Components for SIRT7 Gene

Pathways & Interactions for SIRT7 Gene

genes like me logo Genes that share pathways with SIRT7: view

Pathways by source for SIRT7 Gene

1 Sino Biological pathway for SIRT7 Gene
1 Cell Signaling Technology pathway for SIRT7 Gene
2 GeneGo (Thomson Reuters) pathways for SIRT7 Gene
2 Qiagen pathways for SIRT7 Gene

SIGNOR curated interactions for SIRT7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SIRT7 Gene

None

Drugs & Compounds for SIRT7 Gene

(7) Drugs for SIRT7 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 850,854
Resveratrol Experimental, Investigational Pharma Wee1 kinase inhibtor,potent and ATP-competitive, Others, Cyclooxygenase inhibitor 106
Splitomicin Pharma Sir2p inhibitor 0
Panobinostat Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 133
NAD Pharma Full agonist, Agonist 0

(2) Additional Compounds for SIRT7 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3

(5) Tocris Compounds for SIRT7 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Resveratrol Cyclooxygenase inhibitor 501-36-0
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9
Splitomicin Sir2p inhibitor 5690-03-9

(1) ApexBio Compounds for SIRT7 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT7: view

Transcripts for SIRT7 Gene

Unigene Clusters for SIRT7 Gene

Sirtuin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT7 Gene

No ASD Table

Relevant External Links for SIRT7 Gene

GeneLoc Exon Structure for
SIRT7
ECgene alternative splicing isoforms for
SIRT7

Expression for SIRT7 Gene

mRNA expression in normal human tissues for SIRT7 Gene

mRNA differential expression in normal tissues according to GTEx for SIRT7 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for SIRT7 Gene

This gene is overexpressed in Platelet (42.8), Serum (15.6), and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIRT7 Gene



SOURCE GeneReport for Unigene cluster for SIRT7 Gene Hs.514636

genes like me logo Genes that share expression patterns with SIRT7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SIRT7 Gene

Orthologs for SIRT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIRT7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SIRT7 35
  • 90.33 (n)
  • 96 (a)
SIRT7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIRT7 35
  • 89.5 (n)
  • 94 (a)
SIRT7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sirt7 35
  • 86.77 (n)
  • 94.72 (a)
Sirt7 16
Sirt7 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SIRT7 35
  • 99.33 (n)
  • 99.75 (a)
SIRT7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sirt7 35
  • 86.43 (n)
  • 93.97 (a)
oppossum
(Monodelphis domestica)
Mammalia SIRT7 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCYT2 35
  • 73.33 (n)
  • 77.22 (a)
PCYT2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIRT7 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt7 35
  • 62.45 (n)
  • 63.82 (a)
Str.16209 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15780 35
zebrafish
(Danio rerio)
Actinopterygii LOC796135 35
  • 62.84 (n)
  • 66.07 (a)
sirt7 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11305 37
  • 52 (a)
Sirt7 35
  • 55.68 (n)
  • 51.1 (a)
Sirt7 36
  • 26 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8781 35
Species with no ortholog for SIRT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT7 Gene

ENSEMBL:
Gene Tree for SIRT7 (if available)
TreeFam:
Gene Tree for SIRT7 (if available)

Paralogs for SIRT7 Gene

Paralogs for SIRT7 Gene

(1) SIMAP similar genes for SIRT7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIRT7: view

Variants for SIRT7 Gene

Sequence variations from dbSNP and Humsavar for SIRT7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1879568 -- 81,914,253(+) CGGGC(A/G)GGCAG intron-variant
rs1879569 -- 81,914,365(+) GTTCA(A/G)AGGCT nc-transcript-variant, reference, synonymous-codon
rs11559052 -- 81,915,450(+) TCTGC(G/T)CATGC nc-transcript-variant, reference, missense
rs35278165 -- 81,915,053(+) CAGGT(C/T)CCTGG intron-variant
rs34104890 -- 81,916,616(+) TGCCC(A/G)CCACC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SIRT7 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
nsv833571 CNV Loss 17160897

Variation tolerance for SIRT7 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SIRT7 Gene

Disorders for SIRT7 Gene

Relevant External Links for SIRT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRT7

No disorders were found for SIRT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRT7 Gene

Publications for SIRT7 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PMID: 10873683) Frye R.A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
  2. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PMID: 16618798) Ford E. … Guarente L. (Genes Dev. 2006) 2 3
  3. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. (PMID: 16525639) Voelter-Mahlknecht S. … Mahlknecht U. (Int. J. Oncol. 2006) 3 23
  4. Altered sirtuin expression is associated with node-positive breast cancer. (PMID: 17003781) Ashraf N. … Shiels P.G. (Br. J. Cancer 2006) 3 23
  5. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E. … Horikawa I. (Mol. Biol. Cell 2005) 3 23

Products for SIRT7 Gene

Sources for SIRT7 Gene

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