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Aliases for SIRT7 Gene

Aliases for SIRT7 Gene

  • Sirtuin 7 2 3
  • SIR2L7 3 4 6
  • Regulatory Protein SIR2 Homolog 7 3 4
  • SIR2-Like Protein 7 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 7 2
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 7 3
  • NAD-Dependent Protein Deacetylase Sirtuin-7 3
  • NAD-Dependent Deacetylase Sirtuin-7 3
  • Sir2-Related Protein Type 7 3
  • Sirtuin Type 7 3
  • EC 3.5.1.- 4

External Ids for SIRT7 Gene

Summaries for SIRT7 Gene

Entrez Gene Summary for SIRT7 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT7 Gene

SIRT7 (Sirtuin 7) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K18 specific). An important paralog of this gene is SIRT6.

UniProtKB/Swiss-Prot for SIRT7 Gene

  • NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Tocris Summary for SIRT7 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process through their role in resistance to cellular stress.

Gene Wiki entry for SIRT7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT7 Gene

Genomics for SIRT7 Gene

Genomic Location for SIRT7 Gene

Start:
81,911,939 bp from pter
End:
81,921,323 bp from pter
Size:
9,385 bases
Orientation:
Minus strand

Genomic View for SIRT7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT7 Gene

Regulatory Elements for SIRT7 Gene

Proteins for SIRT7 Gene

  • Protein details for SIRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC8-SIR7_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-7
    Protein Accession:
    Q9NRC8
    Secondary Accessions:
    • A8K2K0
    • B3KSU8
    • Q3MIK4
    • Q9NSZ6
    • Q9NUS6

    Protein attributes for SIRT7 Gene

    Size:
    400 amino acids
    Molecular mass:
    44898 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation. Interacts with histone H2A and/or histone H2B.
    Miscellaneous:
    • Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas
    SequenceCaution:
    • Sequence=CAB70848.2; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Alternative splice isoforms for SIRT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT7 Gene

Proteomics data for SIRT7 Gene at MOPED

Post-translational modifications for SIRT7 Gene

Other Protein References for SIRT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIRT7 Gene

Domains for SIRT7 Gene

UniProtKB/Swiss-Prot:

SIR7_HUMAN
Domain:
  • Contains 1 deacetylase sirtuin-type domain.:
    • Q9NRC8
Family:
  • Belongs to the sirtuin family. Class IV subfamily.:
    • Q9NRC8
genes like me logo Genes that share domains with SIRT7: view

No data available for Gene Families for SIRT7 Gene

Function for SIRT7 Gene

Molecular function for SIRT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Enzyme Numbers (IUBMB) for SIRT7 Gene

Gene Ontology (GO) - Molecular Function for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22722849
GO:0005515 protein binding IPI 19174463
GO:0046872 metal ion binding IEA --
GO:0070403 NAD+ binding IEA --
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific) IDA 22722849
genes like me logo Genes that share ontologies with SIRT7: view
genes like me logo Genes that share phenotypes with SIRT7: view

Animal Models for SIRT7 Gene

MGI Knock Outs for SIRT7:

miRNA for SIRT7 Gene

miRTarBase miRNAs that target SIRT7

No data available for Transcription Factor Targeting and HOMER Transcription for SIRT7 Gene

Localization for SIRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT7 Gene

Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRT7 Gene COMPARTMENTS Subcellular localization image for SIRT7 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA 16079181
GO:0005731 nucleolus organizer region IDA 19174463
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIRT7: view

Pathways for SIRT7 Gene

genes like me logo Genes that share pathways with SIRT7: view

Pathways by source for SIRT7 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for SIRT7 Gene
1 Sino Biological pathway for SIRT7 Gene
2 Qiagen pathways for SIRT7 Gene
1 Cell Signaling Technology pathway for SIRT7 Gene

Gene Ontology (GO) - Biological Process for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 22722849
GO:0007072 positive regulation of transcription on exit from mitosis IMP 19174463
GO:0009303 rRNA transcription IMP 19174463
GO:0070932 histone H3 deacetylation IDA 22722849
GO:0070933 histone H4 deacetylation IDA 22722849
genes like me logo Genes that share ontologies with SIRT7: view

Compounds for SIRT7 Gene

(6) ApexBio Compounds for SIRT7 Gene

Compound Action Cas Number
EX 527 (SEN0014196) novel, potential, and specific small-molecule inhibitor of SIRT1 [49843-98-3]
Sirtinol specific SIRT1 and SIRT2 inhibitor [410536-97-9]
sirtuin modulator sirtuin modulator. [1093403-33-8]
SRT1720 activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
Tenovin-3 Tenovin-3 [1011301-27-1]
Tenovin-6 a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

(5) Tocris Compounds for SIRT7 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor [304896-28-4]
AK 7 Selective SIRT2 inhibitor; brain penetrant [420831-40-9]
EX 527 Selective SIRT1 inhibitor [49843-98-3]
Sirtinol Selective sirtuin family deacetylase inhibitor [410536-97-9]
Splitomicin Sir2p inhibitor [5690-03-9]

(1) HMDB Compounds for SIRT7 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with SIRT7: view

Transcripts for SIRT7 Gene

Unigene Clusters for SIRT7 Gene

Sirtuin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT7 Gene

No ASD Table

Relevant External Links for SIRT7 Gene

GeneLoc Exon Structure for
SIRT7
ECgene alternative splicing isoforms for
SIRT7

Expression for SIRT7 Gene

mRNA expression in normal human tissues for SIRT7 Gene

mRNA differential expression in normal tissues according to GTEx for SIRT7 Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIRT7 Gene

SOURCE GeneReport for Unigene cluster for SIRT7 Gene Hs.514636

genes like me logo Genes that share expressions with SIRT7: view

Orthologs for SIRT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIRT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT7 36
  • 99.33 (n)
  • 99.75 (a)
SIRT7 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIRT7 36
  • 90.33 (n)
  • 96 (a)
SIRT7 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIRT7 36
  • 89.5 (n)
  • 94 (a)
SIRT7 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sirt7 36
  • 86.77 (n)
  • 94.72 (a)
Sirt7 16
Sirt7 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIRT7 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sirt7 36
  • 86.43 (n)
  • 93.97 (a)
chicken
(Gallus gallus)
Aves PCYT2 36
  • 73.33 (n)
  • 77.22 (a)
PCYT2 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIRT7 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15780 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt7 36
  • 62.45 (n)
  • 63.82 (a)
Str.16209 36
zebrafish
(Danio rerio)
Actinopterygii LOC796135 36
  • 62.84 (n)
  • 66.07 (a)
sirt7 37
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sirt7 36
  • 55.68 (n)
  • 51.1 (a)
Sirt7 37
  • 26 (a)
OneToOne
CG11305 38
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8781 36
Species with no ortholog for SIRT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT7 Gene

ENSEMBL:
Gene Tree for SIRT7 (if available)
TreeFam:
Gene Tree for SIRT7 (if available)

Paralogs for SIRT7 Gene

Paralogs for SIRT7 Gene

Selected SIMAP similar genes for SIRT7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIRT7: view

Variants for SIRT7 Gene

Sequence variations from dbSNP and Humsavar for SIRT7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1879568 -- 81,914,253(+) CGGGC(A/G)GGCAG intron-variant, reference, missense
rs1879569 -- 81,914,365(+) GTTCA(A/G)AGGCT synonymous-codon, reference, nc-transcript-variant
rs11559052 -- 81,915,450(+) TCTGC(G/T)CATGC reference, missense, nc-transcript-variant
rs34104890 -- 81,916,616(+) TGCCC(A/G)CCACC intron-variant
rs34241371 -- 81,914,651(+) GGCAG(-/C)CCCAC reference, frameshift-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRT7 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
nsv833571 CNV Loss 17160897

Relevant External Links for SIRT7 Gene

HapMap Linkage Disequilibrium report
SIRT7

Disorders for SIRT7 Gene

No disorders were found for SIRT7 Gene.

No data available for UniProtKB/Swiss-Prot for SIRT7 Gene

Publications for SIRT7 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PMID: 10873683) Frye R.A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E. … Horikawa I. (Mol. Biol. Cell 2005) 3 4 23
  3. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PMID: 16618798) Ford E. … Guarente L. (Genes Dev. 2006) 2 3 4
  4. Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. (PMID: 19174463) Grob A. … Sirri V. (J. Cell Sci. 2009) 3 4
  5. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. (PMID: 16525639) Voelter-Mahlknecht S. … Mahlknecht U. (Int. J. Oncol. 2006) 3 23

Products for SIRT7 Gene

  • Addgene plasmids for SIRT7

Sources for SIRT7 Gene

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