Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SIRT7 Gene

Aliases for SIRT7 Gene

  • Sirtuin 7 2 3 5
  • Regulatory Protein SIR2 Homolog 7 3 4
  • SIR2-Like Protein 7 3 4
  • SIR2L7 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 7 2
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 7 3
  • NAD-Dependent Protein Deacetylase Sirtuin-7 3
  • NAD-Dependent Deacetylase Sirtuin-7 3
  • Sir2-Related Protein Type 7 3
  • Sirtuin Type 7 3
  • EC 3.5.1.- 4

External Ids for SIRT7 Gene

Previous GeneCards Identifiers for SIRT7 Gene

  • GC17M079361
  • GC17M9I0172
  • GC17M080405
  • GC17M9I0548
  • GC17M9I7463
  • GC17M077464
  • GC17M077465
  • GC17M079869
  • GC17M075271

Summaries for SIRT7 Gene

Entrez Gene Summary for SIRT7 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT7 Gene

SIRT7 (Sirtuin 7) is a Protein Coding gene. Among its related pathways are DNA damage_NHEJ mechanisms of DSBs repair and Signaling events mediated by HDAC Class III. GO annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K18 specific). An important paralog of this gene is SIRT6.

UniProtKB/Swiss-Prot for SIRT7 Gene

  • NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Tocris Summary for SIRT7 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT7 Gene

Genomics for SIRT7 Gene

Regulatory Elements for SIRT7 Gene

Enhancers for SIRT7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G082492 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10 -574.2 -574170 6.0 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 NARF ENSG00000262049 HGS ENSG00000262652 ARL2BPP9 ALYREF NARF-IT1 RFNG ENSG00000265678 OGFOD3
GH17G082211 1.7 Ensembl ENCODE dbSUPER 10 -294.7 -294681 8.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000262049 CCDC57 NARF-IT1 HGS TEPSIN ENSG00000262652 CEP131 ARL2BPP9 OGFOD3 ENSG00000265678
GH17G081884 1.3 ENCODE dbSUPER 11.9 +35.3 35316 3.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 FOS SP3 P4HB SIRT7 MAFG PYCR1 ENSG00000235296 MYADML2 GC17P081887 GC17P081881
GH17G082518 1.4 ENCODE dbSUPER 10 -599.6 -599634 4.7 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 HGS ENSG00000262049 ENSG00000262652 ARL2BPP9 NARF-IT1 ALYREF OGFOD3 ENSG00000265678 SIRT7 CCDC137
GH17G081294 1.3 ENCODE dbSUPER 10 +625.9 625893 2.7 HDGF ARNT ZFP64 ARID4B SIN3A YY1 ZNF143 DEK SP3 SP5 SLC38A10 TEPSIN HGS ENSG00000262049 NDUFAF8 ALYREF ENSG00000265678 CHMP6 SIRT7 CCDC137
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRT7 on UCSC Golden Path with GeneCards custom track

Promoters for SIRT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099501 282 1001 HDGF ARNT AGO1 ZNF133 WRNIP1 ARID4B SIN3A ZNF143 PAF1 SP3

Genomic Location for SIRT7 Gene

Chromosome:
17
Start:
81,911,939 bp from pter
End:
81,921,323 bp from pter
Size:
9,385 bases
Orientation:
Minus strand

Genomic View for SIRT7 Gene

Genes around SIRT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT7 Gene

Proteins for SIRT7 Gene

  • Protein details for SIRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC8-SIR7_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-7
    Protein Accession:
    Q9NRC8
    Secondary Accessions:
    • A8K2K0
    • B3KSU8
    • Q3MIK4
    • Q9NSZ6
    • Q9NUS6

    Protein attributes for SIRT7 Gene

    Size:
    400 amino acids
    Molecular mass:
    44898 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation. Interacts with histone H2A and/or histone H2B.
    Miscellaneous:
    • Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas.
    SequenceCaution:
    • Sequence=CAB70848.2; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Alternative splice isoforms for SIRT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT7 Gene

Post-translational modifications for SIRT7 Gene

Other Protein References for SIRT7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIRT7 (SIRT7)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SIRT7

No data available for DME Specific Peptides for SIRT7 Gene

Domains & Families for SIRT7 Gene

Gene Families for SIRT7 Gene

Suggested Antigen Peptide Sequences for SIRT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRC8

UniProtKB/Swiss-Prot:

SIR7_HUMAN :
  • Belongs to the sirtuin family. Class IV subfamily.
Family:
  • Belongs to the sirtuin family. Class IV subfamily.
genes like me logo Genes that share domains with SIRT7: view

Function for SIRT7 Gene

Molecular function for SIRT7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Enzyme Numbers (IUBMB) for SIRT7 Gene

Gene Ontology (GO) - Molecular Function for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22722849
GO:0005515 protein binding IPI 19174463
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0070403 NAD+ binding IEA --
genes like me logo Genes that share ontologies with SIRT7: view
genes like me logo Genes that share phenotypes with SIRT7: view

Animal Models for SIRT7 Gene

MGI Knock Outs for SIRT7:

Animal Model Products

CRISPR Products

miRNA for SIRT7 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT7 Gene

Localization for SIRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT7 Gene

Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT7 gene
Compartment Confidence
nucleus 5
mitochondrion 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA,IDA 16079181
GO:0005731 nucleolus organizer region IDA 19174463
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIRT7: view

Pathways & Interactions for SIRT7 Gene

genes like me logo Genes that share pathways with SIRT7: view

Pathways by source for SIRT7 Gene

1 Sino Biological pathway for SIRT7 Gene
1 Cell Signaling Technology pathway for SIRT7 Gene
2 GeneGo (Thomson Reuters) pathways for SIRT7 Gene
2 Qiagen pathways for SIRT7 Gene

SIGNOR curated interactions for SIRT7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 22722849
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007072 positive regulation of transcription involved in exit from mitosis IMP 19174463
GO:0009303 rRNA transcription IMP 19174463
genes like me logo Genes that share ontologies with SIRT7: view

Drugs & Compounds for SIRT7 Gene

(7) Drugs for SIRT7 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 135
Nicotinamide Approved Nutra 919,923
Splitomicin Pharma 0
NAD Pharma Full agonist, Agonist 0
AGK 2 Pharma Selective SIRT2 inhibitor 0

(3) Additional Compounds for SIRT7 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3
SirReal 2
709002-46-0

(5) Tocris Compounds for SIRT7 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Salermide SIRT1 and SIRT2 inhibitor 1105698-15-4
SirReal 2 Selective inhibitor of SIRT2 709002-46-0
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9

(1) ApexBio Compounds for SIRT7 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT7: view

Drug Products

Transcripts for SIRT7 Gene

Unigene Clusters for SIRT7 Gene

Sirtuin 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT7

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT7 Gene

No ASD Table

Relevant External Links for SIRT7 Gene

GeneLoc Exon Structure for
SIRT7
ECgene alternative splicing isoforms for
SIRT7

Expression for SIRT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRT7 Gene

mRNA differential expression in normal tissues according to GTEx for SIRT7 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for SIRT7 Gene

This gene is overexpressed in Platelet (42.8), Serum (15.6), and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIRT7 Gene



NURSA nuclear receptor signaling pathways regulating expression of SIRT7 Gene:

SIRT7

SOURCE GeneReport for Unigene cluster for SIRT7 Gene:

Hs.514636

Evidence on tissue expression from TISSUES for SIRT7 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Intestine(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with SIRT7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT7 Gene

Orthologs for SIRT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIRT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT7 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia SIRT7 34 35
  • 90.33 (n)
dog
(Canis familiaris)
Mammalia SIRT7 34 35
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia Sirt7 34 16 35
  • 86.77 (n)
rat
(Rattus norvegicus)
Mammalia Sirt7 34
  • 86.43 (n)
oppossum
(Monodelphis domestica)
Mammalia SIRT7 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCYT2 34 35
  • 73.33 (n)
lizard
(Anolis carolinensis)
Reptilia SIRT7 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt7 34
  • 62.45 (n)
Str.16209 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15780 34
zebrafish
(Danio rerio)
Actinopterygii sirt7 35
  • 63 (a)
OneToOne
LOC796135 34
  • 62.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sirt7 34 35
  • 55.68 (n)
CG11305 36
  • 52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8781 34
Species where no ortholog for SIRT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT7 Gene

ENSEMBL:
Gene Tree for SIRT7 (if available)
TreeFam:
Gene Tree for SIRT7 (if available)

Paralogs for SIRT7 Gene

Paralogs for SIRT7 Gene

(1) SIMAP similar genes for SIRT7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIRT7: view

Variants for SIRT7 Gene

Sequence variations from dbSNP and Humsavar for SIRT7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000041849 -- 81,919,917(+) TGCCA(A/G)CGCAC upstream-variant-2KB, utr-variant-3-prime
rs1000738479 -- 81,911,673(+) CGCCC(C/T)CCGAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001332798 -- 81,916,018(+) TAGTC(A/G)TGTTC intron-variant
rs1001389602 -- 81,915,908(+) CTCAT(C/T)CTTCC intron-variant
rs1001825123 -- 81,918,356(+) TACCC(-/G)GGGGG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SIRT7 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for SIRT7 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT7 Gene

Disorders for SIRT7 Gene

Relevant External Links for SIRT7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRT7

No disorders were found for SIRT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRT7 Gene

Publications for SIRT7 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PMID: 10873683) Frye R.A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PMID: 16618798) Ford E. … Guarente L. (Genes Dev. 2006) 2 3 4 64
  3. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E. … Horikawa I. (Mol. Biol. Cell 2005) 3 4 22 64
  4. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PMID: 22586326) Tsai Y.C. … Cristea I.M. (Mol. Cell. Proteomics 2012) 3 4 64
  5. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. (PMID: 22722849) Barber M.F. … Chua K.F. (Nature 2012) 3 4 64

Products for SIRT7 Gene

  • Addgene plasmids for SIRT7

Sources for SIRT7 Gene

Content
Loading form....