Aliases for SIRT7 Gene
- Sirtuin 7 2 3
- SIR2L7 3 4 6
- Regulatory Protein SIR2 Homolog 7 3 4
- SIR2-Like Protein 7 3 4
- Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae) 2
- Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 7 2
- Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 7 3
External Ids for SIRT7 Gene
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIRT7 Gene
SIRT7 (Sirtuin 7) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K18 specific). An important paralog of this gene is SIRT6.
UniProtKB/Swiss-Prot for SIRT7 Gene
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process through their role in resistance to cellular stress.