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SIRT7 Gene

protein-coding   GIFtS: 59
GCID: GC17M079869

Sirtuin 7

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sirtuin 71 2     NAD-Dependent Deacetylase Sirtuin-72
SIR2L72 3 5     NAD-Dependent Protein Deacetylase Sirtuin-72
Regulatory Protein SIR2 Homolog 72 3     Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 72
SIR2-Like Protein 72 3     Sir2-Related Protein Type 72
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S.
Cerevisiae)1
     Sirtuin Type 72
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae,
Homolog) 71
     EC 3.5.1.-3

External Ids:    HGNC: 149351   Entrez Gene: 515472   Ensembl: ENSG000001875317   OMIM: 6062125   UniProtKB: Q9NRC83   

Export aliases for SIRT7 gene to outside databases

Previous GC identifers: GC17M079361 GC17M9I0172 GC17M080405 GC17M9I0548 GC17M9I7463 GC17M077464 GC17M077465 GC17M075271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIRT7 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class IV of the sirtuin family. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIRT7 Gene:
SIRT7 (sirtuin 7) is a protein-coding gene. GO annotations related to this gene include NAD-dependent histone deacetylase activity (H3-K18 specific) and chromatin binding. An important paralog of this gene is SIRT6.

UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8
Function: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18'
(H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac,
directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of
genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription
repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and
seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in
oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of
H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from
mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates
transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival,
however such data need additional confirmation

summary for SIRT7 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIRT7 gene promoter:
         HOXA9   TBP   E2F   AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT7 promoter sequence
   Search Chromatin IP Primers for SIRT7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRT7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

SIRT7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079869:  view genomic region     (about GC identifiers)

Start:
79,869,815 bp from pter      End:
79,879,199 bp from pter
Size:
9,385 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-7  
Size: 400 amino acids; 44898 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex,
such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters
for H3K18Ac deacetylation. Interacts with histone H2A and/or histone H2B
Miscellaneous: Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas
Caution: Was originally (PubMed:11953824) termed SIR-T8/SIRT8. This was later retracted (PubMed:12454780). See
also PubMed:12454781
Sequence caution: Sequence=CAB70848.2; Type=Miscellaneous discrepancy;
Secondary accessions: A8K2K0 B3KSU8 Q3MIK4 Q9NSZ6 Q9NUS6
Alternative splicing: 3 isoforms:  Q9NRC8-1   Q9NRC8-2   Q9NRC8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRT7: NX_Q9NRC8

Explore proteomics data for SIRT7 at MOPED

Post-translational modifications: 

  • Phosphorylated during mitosis (Probable)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SIRT7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057622.1  
    ENSEMBL proteins: 
     ENSP00000329466   ENSP00000461044   ENSP00000459524  

    SIRT7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for SIRT7
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    Search eBioscience for ELISAs for SIRT7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003000 Sirtuin
     IPR026590 Ssirtuin_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRC8

    ProtoNet protein and cluster: Q9NRC8

    1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIR7_HUMAN, Q9NRC8
    Similarity: Belongs to the sirtuin family. Class IV subfamily
    Similarity: Contains 1 deacetylase sirtuin-type domain


    Find genes that share domains with SIRT7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIR7_HUMAN, Q9NRC8
    Function: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18'
    (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac,
    directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of
    genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription
    repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and
    seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in
    oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of
    H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from
    mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates
    transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival,
    however such data need additional confirmation
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

         Enzyme Number (IUBMB): EC 3.5.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA--
    GO:0005515protein binding IPI19174463
    GO:0046872metal ion binding IEA--
    GO:0070403NAD+ binding IEA--
    GO:0097372NAD-dependent histone deacetylase activity (H3-K18 specific) IDA--
         
    Find genes that share ontologies with SIRT7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SIRT7:
     Increased cell number in G1, s 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sirt7):
     adipose tissue  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  muscle  no phenotypic analysis 
     pigmentation  skeleton 

    Find genes that share phenotypes with SIRT7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sirt7tm1Evbo for SIRT7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIRT7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIRT7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRT7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIRT7

    miRNA
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    miRTarBase miRNAs that target SIRT7:
    hsa-mir-335-5p (MIRT018583)

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    Selected qRT-PCR Assays for microRNAs that regulate SIRT7 (see all 22):
    hsa-miR-142-5p hsa-miR-125a-5p hsa-miR-148b hsa-miR-411 hsa-miR-106a hsa-miR-340 hsa-miR-125b hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidSIRT7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SIRT7

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SIRT7 (NM_016538)
    Sino Biological Human cDNA Clone for SIRT7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT7
    Addgene plasmids for SIRT7 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIR7_HUMAN, Q9NRC8: Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the
    cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with
    nucleolar organizer regions during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA16079181
    GO:0005731nucleolus organizer region IDA19174463
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SIRT7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIRT7 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    3Non-homologous end-joining
    DNA damage NHEJ mechanisms of DSBs repair0.37
    44-1BB Pathway
    SUMO Pathway0.30
    5Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class III


    Find genes that share SuperPaths with SIRT7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIRT7
        p53 Signaling
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for SIRT7
        Chromatin Regulation / Acetylation

    2 GeneGo (Thomson Reuters) Pathways for SIRT7
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    2 BioSystems Pathways for SIRT7
        Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class I

    1 Sino Biological Pathway for SIRT7
        p53 Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIRT7
    Interactions:

        Search GeneGlobe Interaction Network for SIRT7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIRT7 (Q9NRC82, 3 ENSP000003294664) via UniProtKB, MINT, STRING, and/or I2D (see all 694)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0007072positive regulation of transcription on exit from mitosis IMP19174463
    GO:0009303rRNA transcription IMP19174463
    GO:0070932histone H3 deacetylation IDA--
    GO:0070933histone H4 deacetylation IDA--

    Find genes that share ontologies with SIRT7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    6 ApexBio Compounds for SIRT7     About this table
    CompoundAction CAS #
    EX 527 (SEN0014196)novel, potential, and specific small-molecule inhibitor of SIRT1[49843-98-3]
    Sirtinolspecific SIRT1 and SIRT2 inhibitor[410536-97-9]
    sirtuin modulatorsirtuin modulator[1093403-33-8]
    SRT1720activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
    Tenovin-3Tenovin-3 [1011301-27-1]
    Tenovin-6a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

    Compounds for SIRT7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
    SplitomicinSir2p inhibitor[5690-03-9]
    AGK 2Selective SIRT2 inhibitor[304896-28-4]

    1 HMDB Compound for SIRT7    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIRT7 gene: 
    NM_016538.2  

    Unigene Cluster for SIRT7:

    Sirtuin 7
    Hs.514636  [show with all ESTs]
    Unigene Representative Sequence: AK131437
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000574992 ENST00000572976 ENST00000571832 ENST00000536038 ENST00000328666(uc002kcj.2)
    ENST00000574153 ENST00000576156 ENST00000571233 ENST00000572902 ENST00000572350
    ENST00000577065 ENST00000574495 ENST00000573367 ENST00000571915 ENST00000575360
    ENST00000575244 ENST00000570367 ENST00000572671
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      QuantiTect SYBR Green Assays in human, mouse, rat SIRT7
      QuantiFast Probe-based Assays in human, mouse, rat SIRT7

    Additional mRNA sequence: 

    AF233395.1 AK094326.1 AK131437.1 AK290265.1 AL137626.1 BC017305.2 BC101791.1 BC101793.1 

    20 DOTS entries:

    DT.95287654  DT.454662  DT.101959177  DT.95205939  DT.100821692  DT.120932852  DT.120932841  DT.92428690 
    DT.95205925  DT.120932876  DT.91936508  DT.95205933  DT.120932859  DT.120932867  DT.95205941  DT.100821687 
    DT.100821691  DT.91816305  DT.99987651  DT.446479 

    Selected AceView cDNA sequences (see all 669):

    BE645263 T08554 BM717922 CR591281 AI355838 AU100188 BM981320 AA707425 
    BU625267 BE300003 BI829713 BM694234 AI244689 BM677149 BM456834 BF939653 
    H06817 BE276937 BE676530 BM128148 BM967165 AI569073 BG180327 NM_032711 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIRT7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGAGCTGG
    SIRT7 Expression
    About this image

    SIRT7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIRT7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514636
        Custom PCR Arrays for SIRT7
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SIRT7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirt71 , 5 sirtuin 7 (silent mating type information regulation more5
    sirtuin 71
    86.77(n)1
    94.72(a)1
      11 (84.34 cM)5
    2090111  NM_153056.21  NP_694696.21 
     1206183725 
    chicken
    (Gallus gallus)
    Aves PCYT21 phosphate cytidylyltransferase 2, ethanolamine 73.33(n)
    77.22(a)
      422093  NM_001031106.1  NP_001026277.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIRT76
    sirtuin 7
    75(a)
    1 ↔ 1
    2(118482249-118490171)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157802 Xenopus laevis transcribed sequence with weak similarity more 75.36(n)    BX842913.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7961351 novel protein similar to vertebratesirtuin (silent more 62.84(n)
    66.07(a)
      796135  XM_001336402.4  XP_001336438.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113053
    Sirt71
    Sirt71 52(a)3
    55.68(n)1
    51.1(a)1
      98F63
    434331  NM_143407.21  NP_651664.21 


    ENSEMBL Gene Tree for SIRT7 (if available)
    TreeFam Gene Tree for SIRT7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIRT7 gene
    SIRT62  
    1 SIMAP similar gene for SIRT7 using alignment to 3 protein entries:     SIR7_HUMAN (see all proteins):
    SIRT6

    Find genes that share paralogs with SIRT7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for SIRT7    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3749417351,2
    ----79871514(+) ACCAC-/CACGCTTC 1 -- int10--------
    rs3746530491,2
    ----79875312(+) TTTTT-/TAACTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SIRT7 (79869815 - 79879199 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIRT7 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    nsv909161CNV Loss21882294
    esv29964CNV Loss17803354
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3342n71CNV Loss21882294
    nsv833571CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIRT7
    DNA2.0 Custom Variant and Variant Library Synthesis for SIRT7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606212    OMIM disorders: --


    Find genes that share disorders with SIRT7           About GenesLikeMe


    Export disorders for SIRT7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIRT7 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SIRT7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PubMed id 10873683)1, 2, 3, 9 Frye R.A. (Biochem. Biophys. Res. Commun. 2000)
    2. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PubMed id 16618798)1, 2, 3 Ford E.... Guarente L. (Genes Dev. 2006)
    3. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2, 9 Michishita E.... Horikawa I. (Mol. Biol. Cell 2005)
    4. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1, 2 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    5. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. (PubMed id 22722849)1, 2 Barber M.F.... Chua K.F. (Nature 2012)
    6. Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. (PubMed id 19174463)1, 2 Grob A....Sirri V. (J. Cell Sci. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. (PubMed id 11953824)1, 2 de Nigris F.... Fusco A. (Br. J. Cancer 2002)
    10. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. (PubMed id 12454780)1, 2 De Nigris F....Fusco A. (Br. J. Cancer 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51547 HGNC: 14935 AceView: MAFGandPCYT2andSIRT7 Ensembl:ENSG00000187531 euGenes: HUgn51547
    ECgene: SIRT7 H-InvDB: SIRT7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIRT7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIRT7 gene:
    Search GeneIP for patents involving SIRT7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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