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SIRT6 Gene

protein-coding   GIFtS: 62
GCID: GC19M004125

Sirtuin 6

(Previous names: sirtuin (silent mating type information regulation 2, S....)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sirtuin 61 2     NAD-Dependent Deacetylase Sirtuin-62
SIR2L62 3 5     NAD-Dependent Protein Deacetylase Sirtuin-62
Regulatory Protein SIR2 Homolog 62 3     Sir2-Related Protein Type 62
SIR2-Like Protein 62 3     Sirtuin Type 62
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 6 (S.
Cerevisiae)1
     EC 3.5.1.-3
Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae,
Homolog) 61
     

External Ids:    HGNC: 149341   Entrez Gene: 515482   Ensembl: ENSG000000774637   OMIM: 6062115   UniProtKB: Q8N6T73   

Export aliases for SIRT6 gene to outside databases

Previous GC identifers: GC19M004266 GC19M004114 GC19M003937


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIRT6 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class IV of the sirtuin family. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, Jul 2010)

GeneCards Summary for SIRT6 Gene:
SIRT6 (sirtuin 6) is a protein-coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ binding. An important paralog of this gene is SIRT7.

UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7
Function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac.
Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates
histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B
target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple
glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF
protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with
RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for
normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal
glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via
deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated
substrate

summary for SIRT6 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIRT6 gene promoter:
         RFX1   Olf-1   MIF-1   Nkx2-5   HEN1   FOXI1   FOXJ2 (long isoform)   ARP-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT6 promoter sequence
   Search Chromatin IP Primers for SIRT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SIRT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004125:  view genomic region     (about GC identifiers)

Start:
4,174,106 bp from pter      End:
4,182,601 bp from pter
Size:
8,496 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-6  
Size: 355 amino acids; 39119 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8
Miscellaneous: The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction
of the deacetylase activity and may not be physiologically relevant (By similarity)
Sequence caution: Sequence=AAC34468.1; Type=Erroneous gene model prediction; Sequence=AAD15478.1; Type=Erroneous
gene model prediction; Sequence=AAH04218.1; Type=Erroneous translation; Note=Wrong choice of CCDS;
4 PDB 3D structures from and Proteopedia for SIRT6:
3K35 (3D)        3PKI (3D)        3PKJ (3D)        3ZG6 (3D)    
Secondary accessions: B2RCD0 O75291 Q6IAF5 Q6PK99 Q8NCD2 Q9BSI5 Q9BWP3 Q9NRC7 Q9UQD1
Alternative splicing: 2 isoforms:  Q8N6T7-1   Q8N6T7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRT6: NX_Q8N6T7

Explore proteomics data for SIRT6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys245, Lys267
  • Modification sites at PhosphoSitePlus

  • See SIRT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180214.1  NP_057623.2  

    ENSEMBL proteins: 
     ENSP00000473085   ENSP00000469001   ENSP00000305310   ENSP00000337332   ENSP00000471123  
     ENSP00000472023   ENSP00000470215   ENSP00000471837   ENSP00000371360  

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    Novus Biologicals SIRT6 Proteins
    Novus Biologicals SIRT6 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SIRT6

     
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    Cloud-Clone Corp. ELISAs for SIRT6
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    Search eBioscience for ELISAs for SIRT6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003000 Sirtuin
     IPR026590 Ssirtuin_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8N6T7

    ProtoNet protein and cluster: Q8N6T7

    1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7
    Similarity: Belongs to the sirtuin family. Class IV subfamily
    Similarity: Contains 1 deacetylase sirtuin-type domain


    Find genes that share domains with SIRT6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIR6_HUMAN, Q8N6T7
    Function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac.
    Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates
    histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B
    target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple
    glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF
    protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with
    RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for
    normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal
    glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via
    deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated
    substrate
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

         Enzyme Number (IUBMB): EC 3.5.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity TAS17456799
    GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS--
    GO:0005515protein binding IPI19135889
    GO:0008270zinc ion binding ISS--
    GO:0017136NAD-dependent histone deacetylase activity ISS--
         
    Find genes that share ontologies with SIRT6           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sirt6):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  reproductive system  skeleton  vision/eye 

    Find genes that share phenotypes with SIRT6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SIRT6: Sirt6tm2.2Cxd Sirt6tm2.1Cxd Sirt6tm1Fwa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIRT6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIRT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIRT6

    miRNA
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    hsa-miR-34b* hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a hsa-miR-33a hsa-miR-34a hsa-miR-520g hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidSIRT6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SIRT6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SIRT6 (NM_016539)
    Sino Biological Human cDNA Clone for SIRT6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT6
    Addgene plasmids for SIRT6 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIR6_HUMAN, Q8N6T7: Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin
    regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm IDA16079181
    GO:0005724nuclear telomeric heterochromatin IDA18337721
    GO:0005730NOT nucleolus IDA16079181

    Find genes that share ontologies with SIRT6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIRT6 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    3Non-homologous end-joining
    DNA damage NHEJ mechanisms of DSBs repair0.37
    44-1BB Pathway
    SUMO Pathway0.30
    5SREBF and miR33 in cholesterol and lipid homeostasis
    SREBF and miR33 in cholesterol and lipid homeostasis


    Find genes that share SuperPaths with SIRT6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIRT6
        p53 Signaling
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for SIRT6
        Chromatin Regulation / Acetylation

    2 GeneGo (Thomson Reuters) Pathways for SIRT6
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    2 BioSystems Pathways for SIRT6
        SREBF and miR33 in cholesterol and lipid homeostasis
    Signaling events mediated by HDAC Class I

    1 Sino Biological Pathway for SIRT6
        p53 Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including SIRT6: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SIRT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIRT6 (Q8N6T71, 2, 3 ENSP000003373324) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELF5Q9UKW62, 3, ENSP000003110104MINT-67097 I2D: score=4 STRING: ENSP00000311010
    FAF1Q9UNN52, 3MINT-8270715 I2D: score=2 
    VIMP086702, 3, ENSP000002242374MINT-64930 MINT-8270737 I2D: score=4 STRING: ENSP00000224237
    CHD3Q128732, 3, ENSP000003697164MINT-64931 MINT-8270704 I2D: score=4 STRING: ENSP00000369716
    RELAQ042061, 3, ENSP000003842734EBI-712415,EBI-73886 I2D: score=2 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471protein ADP-ribosylation TAS17456799
    GO:0010569regulation of double-strand break repair via homologous recombination IDA19135889
    GO:0016575histone deacetylation ISS--
    GO:0070932histone H3 deacetylation IDA18337721

    Find genes that share ontologies with SIRT6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    6 ApexBio Compounds for SIRT6     About this table
    CompoundAction CAS #
    EX 527 (SEN0014196)novel, potential, and specific small-molecule inhibitor of SIRT1[49843-98-3]
    Sirtinolspecific SIRT1 and SIRT2 inhibitor[410536-97-9]
    sirtuin modulatorsirtuin modulator[1093403-33-8]
    SRT1720activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
    Tenovin-3Tenovin-3 [1011301-27-1]
    Tenovin-6a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

    Compounds for SIRT6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
    SplitomicinSir2p inhibitor[5690-03-9]
    AGK 2Selective SIRT2 inhibitor[304896-28-4]

    5 HMDB Compounds for SIRT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIRT6 gene (2 alternative transcripts): 
    NM_001193285.1  NM_016539.2  

    Unigene Cluster for SIRT6:

    Sirtuin 6
    Hs.423756  [show with all ESTs]
    Unigene Representative Sequence: NM_016539
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599365 ENST00000601488 ENST00000305232 ENST00000337491(uc002lzo.3 uc002lzq.3 uc002lzp.3 uc010xid.2 uc002lzr.3)
    ENST00000600938 ENST00000594279 ENST00000596119 ENST00000597896 ENST00000595670
    ENST00000600540 ENST00000601571 ENST00000601069 ENST00000596298 ENST00000599394
    ENST00000594341 ENST00000381935
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      QuantiFast Probe-based Assays in human, mouse, rat SIRT6

    Additional mRNA sequence: 

    AF233396.1 AK074810.1 AK225567.1 AK293348.1 AK299420.1 AK301247.1 AK315048.1 AL365375.1 
    BC004218.2 BC005026.1 BC028220.1 CR457200.1 

    18 DOTS entries:

    DT.111453  DT.91868508  DT.100695090  DT.95092955  DT.92432257  DT.100783089  DT.100783083  DT.95092936 
    DT.95092937  DT.102829791  DT.102829792  DT.95078754  DT.100027169  DT.121424965  DT.121424973  DT.75174365 
    DT.95214663  DT.100695089 

    Selected AceView cDNA sequences (see all 166):

    CR590451 CR601886 CR615004 BC005026 BQ220614 CR600586 BM544459 BE253366 
    CR618222 BI871432 CR611152 AA482543 BE250802 CR596220 CA389461 BM128833 
    BM722178 BU956920 BM711597 CR593044 AK074810 AA514518 CR619282 BE263531 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIRT6 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
    SP1:                          -     -                 -     -                             -           -                       -                                 
    SP2:                          -     -                 -     -                             -           -     -                 -                                 
    SP3:                                                  -     -                             -           -     -                 -                                 
    SP4:                          -     -                 -     -                             -     -     -                       -                                 
    SP5:                          -     -                 -     -                             -           -                                                         


    ECgene alternative splicing isoforms for SIRT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIRT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTGCAG
    SIRT6 Expression
    About this image

    SIRT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIRT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.423756
        Pathway & Disease-focused RT2 Profiler PCR Array including SIRT6: 
              Telomeres & Telomerase in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SIRT6 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirt61 , 5 sirtuin 6 (silent mating type information regulation more5
    sirtuin 61
    82.93(n)1
    88.62(a)1
      10 (39.72 cM)5
    507211  NM_181586.31  NP_853617.11 
     816217855 
    chicken
    (Gallus gallus)
    Aves SIRT61 sirtuin 6 73.54(n)
    77.19(a)
      428332  NM_001039320.1  NP_001034409.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIRT66
    sirtuin 6
    66(a)
    1 ↔ 1
    AAWZ02041818(3377-5222)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.196022 Xenopus laevis transcribed sequence with moderate similarity more 72.85(n)    BX853463.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sirt61 sirtuin (silent mating type information regulation more 68.67(n)
    73.14(a)
      415161  NM_001002071.1  NP_001002071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62843
    Sirt61
    Sirt61 51(a)3
    54.35(n)1
    52.54(a)1
      86A33
    412541  NM_141733.31  NP_649990.21 
    worm
    (Caenorhabditis elegans)
    Secernentea sir-2.43   -- 38(a)   I(5999207-6000764)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SRT11 SRT1 51.85(n)
    52.22(a)
      835670  NM_124958.2  NP_200387.1 
    rice
    (Oryza sativa)
    Liliopsida Os.23162 Oryza sativa subsp. indica SIR2-like protein mRNA, more 71.08(n)    AK069000.1 


    ENSEMBL Gene Tree for SIRT6 (if available)
    TreeFam Gene Tree for SIRT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIRT6 gene
    SIRT72  
    1 SIMAP similar gene for SIRT6 using alignment to 7 protein entries:     SIR6_HUMAN (see all proteins):
    SIRT7

    Find genes that share paralogs with SIRT6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIRT6 (see all 342)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2002267671,2
    C--4173636(+) TCCAG-/AGGCGG 2 -- ds50010--------
    rs2015487721,2
    --4173636(+) CCAGA-/TGGCGG 2 -- ds50010--------
    rs118788681,2
    C,F,H--4173637(+) CCAGAG/TGCGGG 2 -- ds500113Minor allele frequency- T:0.18NS EA NA 1980
    rs3508471,2
    C,H--4173639(-) ACCCCC/GCCTCT 2 -- ds500112Minor allele frequency- G:0.15MN NA WA CSA EA 557
    rs1154626071,2
    F--4173708(+) CGGAGC/TCCAAG 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1912234891,2
    --4173824(+) GTTAAA/GTCCAG 2 -- ds50010--------
    rs1832263431,2
    --4173832(+) CAGCAC/GTTTGG 2 -- ds50010--------
    rs1879413611,2
    --4174022(+) CTGCAA/GTGAGC 2 -- ds50010--------
    rs1429570771,2
    --4174029(+) GAGCTA/GAGATC 2 -- ds50010--------
    rs1138550821,2
    C--4174056(+) GCCTTG/AGTGAC 2 -- ds50011Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for SIRT6 (4174106 - 4182601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SIRT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833716CNV Loss17160897
    nsv910783CNV Loss21882294
    nsv910816CNV Loss21882294
    dgv3673n71CNV Loss21882294
    nsv910818CNV Loss21882294
    nsv910817CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIRT6
    DNA2.0 Custom Variant and Variant Library Synthesis for SIRT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606211    OMIM disorders: --


    Find genes that share disorders with SIRT6           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SIRT6 (2 documents)

    Export disorders for SIRT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIRT6 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with SIRT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PubMed id 10873683)1, 2, 3, 9 Frye R.A. (Biochem. Biophys. Res. Commun. 2000)
    2. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2, 9 Michishita E.... Horikawa I. (Mol. Biol. Cell 2005)
    3. Structure and biochemical functions of SIRT6. (PubMed id 21362626)1, 2 Pan P.W....Denu J.M. (J. Biol. Chem. 2011)
    4. Human SIRT6 promotes DNA end resection through CtIP deacetylation. (PubMed id 20829486)1, 2 Kaidi A.... Jackson S.P. (Science 2010)
    5. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. (PubMed id 19135889)1, 2 Kawahara T.L.A....Chua K.F. (Cell 2009)
    6. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. (PubMed id 19625767)1, 2 Michishita E.... Chua K.F. (Cell Cycle 2009)
    7. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. (PubMed id 18337721)1, 2 Michishita E.... Chua K.F. (Nature 2008)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51548 HGNC: 14934 AceView: SIRT6 Ensembl:ENSG00000077463 euGenes: HUgn51548
    ECgene: SIRT6 H-InvDB: SIRT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SIRT6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SIRT6 gene:
    Search GeneIP for patents involving SIRT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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