SIRT6 Gene
protein-coding GIFtS: 61
GCID: GC19M004125
|
|
sirtuin 6(Previous names: sirtuin (silent mating type information regulation 2, S....)
| |
Aliases
for SIRT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sirtuin 61 2 | | NAD-Dependent Deacetylase Sirtuin-62 | | SIR2L62 3 5 | | NAD-Dependent Protein Deacetylase Sirtuin-62 | | Regulatory Protein SIR2 Homolog 62 3 | | Sir2-Related Protein Type 62 | | SIR2-Like Protein 62 3 | | Sirtuin Type 62 | | Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 6 (S. Cerevisiae)1 | | EC 3.5.1.-3 | | Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 61 | | |
Export aliases for SIRT6 gene to outside databasesPrevious GC identifers: GC19M004266 GC19M004114 GC19M003937 |
Summaries
for SIRT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SIRT6:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of thesirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of humansirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencingand suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatoryproteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of thesirtuin family. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jul 2010)
UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7Function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulatesacetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac atNF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as acorepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulateglucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in theregulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. Maybe required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required forgenomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescenceand apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylaseactivity and can bind NAD(+) in the absence of acetylated substrate
 summary
for SIRT6: Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.
Gene Wiki entry for SIRT6
|
Genomic Views
for SIRT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIRT6 gene promoter:
RFX1 Olf-1 MIF-1 Nkx2-5 HEN1 FOXI1 FOXJ2 (long isoform) ARP-1 FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIRT6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3SIRT6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M004125: view genomic region
(about GC identifiers)
Start:
|
4,174,106 bp from pter |
End:
|
4,182,596 bp from pter |
Size:
|
8,491 bases |
Orientation:
|
minus strand |
|
Proteins
for SIRT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7 (See
protein sequence)Recommended Name: NAD-dependent protein deacetylase sirtuin-6 Size: 355 amino acids; 39119 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8
Subcellular location: Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatinregions
Miscellaneous: The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of thedeacetylase activity and may not be physiologically relevant (By similarity)
Sequence caution: Sequence=AAC34468.1; Type=Erroneous gene model prediction; Sequence=AAD15478.1; Type=Erroneous genemodel prediction; Sequence=AAH04218.1; Type=Erroneous translation; Note=Wrong choice of CCDS;
3 PDB 3D structures from  and Proteopedia  for SIRT6:3K35 (3D)
3PKI (3D)
3PKJ (3D)
Secondary accessions: B2RCD0 O75291 Q6IAF5 Q6PK99 Q8NCD2 Q9BSI5 Q9BWP3 Q9NRC7 Q9UQD1Alternative splicing: 2 isoforms: Q8N6T7-1 Q8N6T7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SIRT6: NX_Q8N6T7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N6T7
SIRT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001180214.1 NP_057623.2
ENSEMBL proteins: ENSP00000337332 ENSP00000305310 ENSP00000371360
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SIRT6 for ontologies About GeneDecksing
SIRT6 Antibody Products:
Assay Products for SIRT6: |
Protein
Domains /
Families
for SIRT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIRT6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N6T7ProtoNet protein and cluster: Q8N6T7 1 Blocks protein family: IPB003000 Silent information regulator protein Sir2
UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7Similarity: Belongs to the sirtuin family. Class IV subfamilySimilarity: Contains 1 deacetylase sirtuin-type domain |
Function
for SIRT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SIR6_HUMAN, Q8N6T7Function: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulatesacetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac atNF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as acorepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulateglucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in theregulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. Maybe required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required forgenomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescenceand apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylaseactivity and can bind NAD(+) in the absence of acetylated substrateCatalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a proteinEnzyme Number (IUBMB): EC 3.5.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): SIRT6 (NM_016539) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT6 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
SIRT6 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for SIRT6: Sirt6tm2.2Cxd Sirt6tm2.1Cxd Sirt6tm1Fwa
15 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Sirt6):
SIRT6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SIRT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | NAD metabolism | | | 2 | Non-homologous end-joining | | | 3 | Signaling events mediated by HDAC Class I | | | 4 | Chromatin Regulation / Acetylation | | | 5 | Chks in Checkpoint Regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for SIRT6
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT6
1 
Cell Signaling Technology (CST) Pathway for SIRT6
2  GeneGo (Thomson Reuters) Pathways for SIRT6
1  BioSystems Pathway for SIRT6
SIRT6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIRT6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/16 Interacting proteins for SIRT6 (Q8N6T71, 2, 3 ENSP000003373324) via UniProtKB, MINT, STRING, and/or I2D (see all 16)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ELF5 | Q9UKW62, 3, ENSP000003110104 | MINT-67097 I2D:
score=4 STRING: ENSP00000311010 | | FAF1 | Q9UNN52, 3 | MINT-8270715 I2D:
score=2 | | VIM | P086702, 3, ENSP000002242374 | MINT-64930 MINT-8270737 I2D:
score=4 STRING: ENSP00000224237 | | CHD3 | Q128732, 3, ENSP000003697164 | MINT-64931 MINT-8270704 I2D:
score=4 STRING: ENSP00000369716 | | RELA | Q042061, 3, ENSP000003842734 | EBI-712415,EBI-73886 I2D:
score=2 STRING: ENSP00000384273 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SIRT6 for ontologies About GeneDecksing
|
Drugs & Compounds
for SIRT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for SIRT6 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| Sirtinol | Selective sirtuin family deacetylase inhibitor | [410536-97-9] | | Splitomicin | Sir2p inhibitor | [5690-03-9] |
5 HMDB Compounds for SIRT6 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| L-Arginine | (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14) | 74-79-3 | -- | | NAD | 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28) | 53-84-9 | -- | | NADH | 1,4-Dihydronicotinamide adenine dinucleotide (see all 17) | 58-68-4 | -- | | NADP | Adenine-nicotinamide dinucleotide phosphate (see all 18) | 53-59-8 | -- | | Niacinamide | 3-Carbamoylpyridine (see all 77) | 98-92-0 | -- |
Search CenterWatch for drugs/clinical trials and news about SIRT6 / SIR6
|
Transcripts
for SIRT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIRT6 gene (2 alternative transcripts): NM_001193285.1 NM_016539.2 Unigene Cluster for SIRT6: Sirtuin 6 Hs.423756 [show with all ESTs]Unigene Representative Sequence: NM_0165393 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337491(uc002lzo.3 uc002lzq.3 uc002lzp.3 uc010xid.2 uc002lzr.3)
ENST00000305232 ENST00000381935
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SIRT6 (NM_016539) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRT6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT6 |
Additional cDNA sequence: AF233396.1 AK074810.1 AK225567.1 AK293348.1 AK299420.1 AK301247.1 AK315048.1 AL365375.1 BC004218.2 BC005026.1 BC028220.1 CR457200.1 18 DOTS entries: DT.111453 DT.91868508 DT.100695090 DT.95092955 DT.92432257 DT.100783089 DT.100783083 DT.95092936 DT.95092937 DT.102829791 DT.102829792 DT.95078754 DT.100027169 DT.121424965 DT.121424973 DT.75174365 DT.95214663 DT.100695089 24/166 AceView cDNA sequences (see all 166): BM722178 BE250802 BU956920 CR596220 BM544459 CR615004 CR600586 CR601886 CR590451 BM711597 AA482543 BE253366 CR618222 AA514518 BM128833 BI871432 BC005026 BU557928 CR611152 CA389461 CK819458 CR619282 AK074810 BE263531
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT6 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIRT6
|
Expression
for SIRT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIRT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCTGCAG
About this image
See SIRT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRT6
SOURCE GeneReport for Unigene cluster: Hs.423756
SABiosciences Expression via Pathway-Focused PCR Array including SIRT6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRT6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SIRT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT6 |
Orthologs
for SIRT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for SIRT6 gene from 8/32 species (see all 32) About this table
ENSEMBL Gene Tree for SIRT6 (if available)
TreeFam Gene Tree for SIRT6 (if available) |
Paralogs
for SIRT6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIRT6 gene
- SIRT72
1 SIMAP similar gene for SIRT6 using alignment to 7 protein entries: SIR6_HUMAN (see all proteins):SIRT7
SIRT6 for paralogs About GeneDecksing
|
Genomic Variants
for SIRT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIRT6 (4174106 - 4182596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SIRT6
1 CNV: 5074 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRT6 |
|
Disorders
/ Diseases
for SIRT6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SIRT6 for disorders About GeneDecksing
OMIM gene information: 606211
OMIM disorders: --
1  disease for SIRT6: About MalaCardsmood disorder
Human Genome Epidemiology (HuGE) Navigator: SIRT6 (2 documents)
Export disorders for SIRT6 gene to outside databases
|
Publications
for SIRT6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIRT6 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with SIRT6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins. (PubMed id 10873683)1, 2, 3, 9 Frye R.A. (2000)
- Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2, 9 Michishita E.... Horikawa I. (2005)
- Structure and biochemical functions of SIRT6. (PubMed id 21362626)1, 2 Pan P.W....Denu J.M. (2011)
- Human SIRT6 promotes DNA end resection through CtIP d eacetylation. (PubMed id 20829486)1, 2 Kaidi A....Jackson S.P. (2010)
- SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. (PubMed id 19135889)1, 2 Kawahara T.L.A....Chua K.F. (2009)
- Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. (PubMed id 19625767)1, 2 Michishita E.... Chua K.F. (2009)
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. (PubMed id 18337721)1, 2 Michishita E.... Chua K.F. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
|
External Searches for SIRT6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SIRT6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SIRT6 gene
(According to HUGE)
About This Section
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Specialized Databases showing SIRT6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for SIRT6 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for SIRT6 gene:
Search GeneIP for patents involving SIRT6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SIRT6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SIRT6 | | OriGene shRNA RFP for SIRT6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRT6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRT6 | | | OriGene Protein Over-expression Lysate for SIRT6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIRT6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SIRT6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SIRT6 | | OriGene Custom Protein Services for SIRT6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIRT6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRT6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRT6 |
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| | Antibodies & Assays for SIRT6 |
| | | | Tocris compounds for SIRT6 |
| |  |  |  |  | | | | | | Recombinant Protein for SIRT6 |
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 | | | SIRT6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT6 |
|  |  |  | | | | ThermoFisher Antibody for SIRT6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT6 |
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