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Aliases for SIRT6 Gene

Aliases for SIRT6 Gene

  • Sirtuin 6 2 3 5
  • Regulatory Protein SIR2 Homolog 6 3 4
  • SIR2-Like Protein 6 3 4
  • SIR2L6 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 6 2
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 6 (S. Cerevisiae) 2
  • NAD-Dependent Protein Deacetylase Sirtuin-6 3
  • Sir2-Related Protein Type 6 3
  • Sirtuin Type 6 3
  • EC 3.5.1.- 4

External Ids for SIRT6 Gene

Previous GeneCards Identifiers for SIRT6 Gene

  • GC19M004266
  • GC19M004114
  • GC19M004125
  • GC19M003937

Summaries for SIRT6 Gene

Entrez Gene Summary for SIRT6 Gene

  • This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for SIRT6 Gene

SIRT6 (Sirtuin 6) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and 4-1BB Pathway. GO annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K9 specific). An important paralog of this gene is SIRT7.

UniProtKB/Swiss-Prot for SIRT6 Gene

  • NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Tocris Summary for SIRT6 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT6 Gene

Additional gene information for SIRT6 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT6 Gene

Genomics for SIRT6 Gene

Regulatory Elements for SIRT6 Gene

Enhancers for SIRT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H004181 1.1 ENCODE 22.9 +0.7 666 2 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CACTIN SIRT6 CACTIN-AS1 TICAM1 LOC100287614 ENSG00000266959 LOC105372244 ENSG00000267030 ENSG00000267138 ENSG00000267769
GH19H004142 1.6 Ensembl ENCODE dbSUPER 13.1 +36.0 36031 7 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 CACTIN SIRT6 ANKRD24 MAP2K2 TMIGD2 FSD1 CCDC94 CREB3L3 LRG1 GC19P004136
GH19H004129 1.5 Ensembl ENCODE dbSUPER 12.4 +51.4 51441 2 PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A TCF12 ZNF121 GATA2 FOS CREB3L3 SIRT6 ANKRD24 CACTIN-AS1 APBA3 CACTIN EEF2 FSD1 TMIGD2 ENSG00000269807
GH19H004204 1.1 Ensembl ENCODE 12.8 -22.3 -22303 0 TBP PKNOX1 RB1 TBL1XR1 ZNF76 THRB ZSCAN9 RAD21 RFX5 TCF12 CCDC94 DPP9-AS1 ENSG00000267030 APBA3 ANKRD24 SIRT6 CREB3L3 ENSG00000267769 EBI3 CACTIN-AS1
GH19H004208 0.8 ENCODE 12 -26.2 -26155 1 BCOR ELF3 CTCF PTBP1 ZMYM3 RAD21 ADNP SMC3 ZNF143 FOS CCDC94 EBI3 SIRT6 ANKRD24 CREB3L3 SNORD37 TMIGD2 FSD1 GC19P004210 GC19M004225
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRT6 on UCSC Golden Path with GeneCards custom track

Promoters for SIRT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106169 204 1601 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for SIRT6 Gene

Chromosome:
19
Start:
4,174,109 bp from pter
End:
4,182,604 bp from pter
Size:
8,496 bases
Orientation:
Minus strand

Genomic View for SIRT6 Gene

Genes around SIRT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT6 Gene

Proteins for SIRT6 Gene

  • Protein details for SIRT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6T7-SIR6_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-6
    Protein Accession:
    Q8N6T7
    Secondary Accessions:
    • B2RCD0
    • O75291
    • Q6IAF5
    • Q6PK99
    • Q8NCD2
    • Q9BSI5
    • Q9BWP3
    • Q9NRC7
    • Q9UQD1

    Protein attributes for SIRT6 Gene

    Size:
    355 amino acids
    Molecular mass:
    39119 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.
    Miscellaneous:
    • The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
    SequenceCaution:
    • Sequence=AAC34468.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD15478.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH04218.1; Type=Erroneous translation; Note=Wrong choice of CCDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIRT6 Gene

    Alternative splice isoforms for SIRT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT6 Gene

Post-translational modifications for SIRT6 Gene

  • Ubiquitination at Lys245 and isoforms=2267
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SIRT6 (SIRT6)
  • Abcam antibodies for SIRT6
  • Santa Cruz Biotechnology (SCBT) Antibodies for SIRT6

No data available for DME Specific Peptides for SIRT6 Gene

Domains & Families for SIRT6 Gene

Gene Families for SIRT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SIRT6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6T7

UniProtKB/Swiss-Prot:

SIR6_HUMAN :
  • Belongs to the sirtuin family. Class IV subfamily.
Family:
  • Belongs to the sirtuin family. Class IV subfamily.
genes like me logo Genes that share domains with SIRT6: view

Function for SIRT6 Gene

Molecular function for SIRT6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Enzyme Numbers (IUBMB) for SIRT6 Gene

Phenotypes From GWAS Catalog for SIRT6 Gene

Gene Ontology (GO) - Molecular Function for SIRT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS,IEA --
GO:0005515 protein binding IPI 19135889
genes like me logo Genes that share ontologies with SIRT6: view
genes like me logo Genes that share phenotypes with SIRT6: view

Animal Models for SIRT6 Gene

MGI Knock Outs for SIRT6:

Animal Model Products

CRISPR Products

miRNA for SIRT6 Gene

miRTarBase miRNAs that target SIRT6

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT6
  • Applied Biological Materials Clones for SIRT6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT6 Gene

Localization for SIRT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT6 Gene

Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT6 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SIRT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005724 nuclear telomeric heterochromatin IDA 18337721
GO:0005730 NOT nucleolus IDA 16079181
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIRT6: view

Pathways & Interactions for SIRT6 Gene

genes like me logo Genes that share pathways with SIRT6: view

Pathways by source for SIRT6 Gene

SIGNOR curated interactions for SIRT6 Gene

Activates:

Gene Ontology (GO) - Biological Process for SIRT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis IEA --
GO:0006284 base-excision repair IEA --
GO:0006471 protein ADP-ribosylation TAS,IEA 17456799
GO:0006476 protein deacetylation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with SIRT6: view

Drugs & Compounds for SIRT6 Gene

(9) Drugs for SIRT6 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 136
L-Arginine Approved Nutra Full agonist, Agonist 0
Nicotinamide Approved Nutra 937,941
Splitomicin Pharma 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for SIRT6 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
O-acetyl-ADP-ribose
EX 527
49843-98-3
SirReal 2
709002-46-0

(5) Tocris Compounds for SIRT6 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Salermide SIRT1 and SIRT2 inhibitor 1105698-15-4
SirReal 2 Selective inhibitor of SIRT2 709002-46-0
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9

(1) ApexBio Compounds for SIRT6 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT6: view

Drug Products

Transcripts for SIRT6 Gene

Unigene Clusters for SIRT6 Gene

Sirtuin 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT6
  • Applied Biological Materials Clones for SIRT6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - - -
SP12: - - - - - - - -
SP13: -
SP14: - -
SP15: - - - - - -
SP16: - - - - - -
SP17: - -

Relevant External Links for SIRT6 Gene

GeneLoc Exon Structure for
SIRT6
ECgene alternative splicing isoforms for
SIRT6

Expression for SIRT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRT6 Gene

Protein differential expression in normal tissues from HIPED for SIRT6 Gene

This gene is overexpressed in Breast (47.1) and NK cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIRT6 Gene



NURSA nuclear receptor signaling pathways regulating expression of SIRT6 Gene:

SIRT6

SOURCE GeneReport for Unigene cluster for SIRT6 Gene:

Hs.423756

Evidence on tissue expression from TISSUES for SIRT6 Gene

  • Liver(4.4)
  • Blood(4.3)
  • Heart(4.3)
  • Lung(4.3)
  • Spleen(4.2)
  • Eye(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with SIRT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT6 Gene

Orthologs for SIRT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SIRT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT6 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia SIRT6 33 34
  • 86.85 (n)
cow
(Bos Taurus)
Mammalia SIRT6 33 34
  • 86.1 (n)
rat
(Rattus norvegicus)
Mammalia Sirt6 33
  • 83.03 (n)
mouse
(Mus musculus)
Mammalia Sirt6 33 16 34
  • 82.93 (n)
oppossum
(Monodelphis domestica)
Mammalia SIRT6 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIRT6 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIRT6 33 34
  • 73.54 (n)
lizard
(Anolis carolinensis)
Reptilia SIRT6 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt6 33
  • 70.62 (n)
MGC76070 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19602 33
zebrafish
(Danio rerio)
Actinopterygii sirt6 33 34
  • 68.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001458 33
  • 58.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sirt6 33 34
  • 54.35 (n)
CG6284 35
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea sir-2.4 35 34
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SRT1 33
  • 51.85 (n)
rice
(Oryza sativa)
Liliopsida Os04g0271000 33
  • 52.96 (n)
Os.2316 33
corn
(Zea mays)
Liliopsida Zm.4848 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToOne
Species where no ortholog for SIRT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIRT6 Gene

ENSEMBL:
Gene Tree for SIRT6 (if available)
TreeFam:
Gene Tree for SIRT6 (if available)

Paralogs for SIRT6 Gene

Paralogs for SIRT6 Gene

(1) SIMAP similar genes for SIRT6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SIRT6: view

Variants for SIRT6 Gene

Sequence variations from dbSNP and Humsavar for SIRT6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs201886868 Uncertain significance 4,174,943(+) ATGGC(A/G)GTCCT reference, synonymous-codon, missense
rs1000986632 -- 4,183,007(+) GGAGC(C/G)TCGCT intron-variant, upstream-variant-2KB
rs1001220975 -- 4,178,152(+) CTCCC(C/G)AGTAG intron-variant
rs1001329127 -- 4,183,982(+) CAGAA(A/C)GAATG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001330851 -- 4,184,119(+) GCCAA(C/T)AGGCA intron-variant, upstream-variant-2KB, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for SIRT6 Gene

Variant ID Type Subtype PubMed ID
nsv833716 CNV loss 17160897

Variation tolerance for SIRT6 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRT6 Gene

Human Gene Mutation Database (HGMD)
SIRT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT6 Gene

Disorders for SIRT6 Gene

Relevant External Links for SIRT6

Human Genome Epidemiology (HuGE) Navigator
SIRT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRT6

No disorders were found for SIRT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRT6 Gene

Publications for SIRT6 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. (PMID: 10873683) Frye RA (Biochemical and biophysical research communications 2000) 2 3 4 22 60
  2. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E … Horikawa I (Molecular biology of the cell 2005) 3 4 22 60
  3. Structure and biochemical functions of SIRT6. (PMID: 21362626) Pan PW … Denu JM (The Journal of biological chemistry 2011) 3 4 60
  4. Human SIRT6 promotes DNA end resection through CtIP deacetylation. (PMID: 20829486) Kaidi A … Jackson SP (Science (New York, N.Y.) 2010) 3 4 60
  5. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. (PMID: 19135889) Kawahara TL … Chua KF (Cell 2009) 3 4 60

Products for SIRT6 Gene

  • Addgene plasmids for SIRT6

Sources for SIRT6 Gene

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