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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIRT5 Gene

protein-coding GIFtS: 60
GCID: GC06P013574

sirtuin 5

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)

Explore 6 diseases affiliated with
SIRT5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sirtuin 5¹ ²		NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial²
Regulatory Protein SIR2 Homolog 5² ³		NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial²
SIR2L5² ³		Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 5²
SIR2-Like Protein 5² ³		Sir2-Like 5²
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 5 (S. Cerevisiae)¹		Sirtuin Type 5²
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5¹		EC 3.5.1.-³
NAD-Dependent Deacetylase Sirtuin-5²

External Ids:	HGNC: 14933¹	Entrez Gene: 23408²	Ensembl: ENSG00000124523⁷	OMIM: 604483⁵	UniProtKB: Q9NXA8³

Export aliases for SIRT5 gene to outside databases

Previous GC identifers: GC06P013632 GC06P013682 GC06P013519

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRT5:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the

sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human

sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing

and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory

proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the

sirtuin family. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jul

2010)

UniProtKB/Swiss-Prot: SIR5_HUMAN, Q9NXA8

Function: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on

target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting:

acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during

fasting. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically

relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro

summary for SIRT5:

Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes

closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or

nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups

from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,

sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and

mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of

transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible

antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process

through their role in resistance to cellular stress.

Gene Wiki entry for SIRT5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIRT5 gene promoter:
POU2F1 HOXA3 Pbx1a POU2F1a AP-4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIRT5 promoter sequence

Search SABiosciences Chromatin IP Primers for SIRT5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23 Ensembl cytogenetic band: 6p23 HGNC cytogenetic band: 6p23

SIRT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT5 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P013574: view genomic region (about GC identifiers)

Start:	13,574,792 bp from pter	End:	13,614,790 bp from pter
Size:	39,999 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIR5_HUMAN, Q9NXA8 (See protein sequence)

Recommended Name: NAD-dependent protein deacylase sirtuin-5, mitochondrial precursor

Size: 310 amino acids; 33881 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding

Subcellular location: Mitochondrion matrix. Mitochondrion intermembrane space

Subcellular location: Isoform 1: Cytoplasm. Mitochondrion

Subcellular location: Isoform 2: Mitochondrion

6/8 PDB 3D structures from and Proteopedia for SIRT5 (see all 8):

2B4Y (3D)

2NYR (3D)

3RIG (3D)

3RIY (3D)

4F4U (3D)

4F56 (3D)

Secondary accessions: B4DFM4 B4DYJ5 F5H5Z9 Q5T294 Q5T295 Q9Y6E6

Alternative splicing: 4 isoforms: Q9NXA8-1 Q9NXA8-2 Q9NXA8-3 Q9NXA8-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRT5: NX_Q9NXA8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NXA8

SIRT5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001180196.1 NP_001229756.1 NP_036373.1 NP_112534.1

ENSEMBL proteins:

ENSP00000368564 ENSP00000368552 ENSP00000352830 ENSP00000380509

Human Recombinant Protein Products:

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	Novus Biologicals SIRT5 Proteins Novus Biologicals SIRT5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SIRT5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--
GO:0005758	mitochondrial intermembrane space	IDA	18680753
GO:0005759	mitochondrial matrix	IDA	18680753

SIRT5 for ontologies About GeneDecksing

SIRT5 Antibody Products:

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	R&D Systems Antibodies for SIRT5 (Sirtuin 5/SIRT5)
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	OriGene Antibodies (see all 10): SIRT5 OriGene Custom Antibody Services for SIRT5
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	Novus Biologicals SIRT5 Antibodies
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	Uscn Antibodies for SIRT5
	ThermoFisher Antibodies for SIRT5

Assay Products for SIRT5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SIRT5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SIRT5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIRT5 for domains About GeneDecksing

3 InterPro domains/families:

IPR003000 Sirtuin

IPR026590 Ssirtuin_cat_dom

IPR026591 Sirtuin_cat_small_dom

Graphical View of Domain Structure for InterPro Entry Q9NXA8

ProtoNet protein and cluster: Q9NXA8

UniProtKB/Swiss-Prot: SIR5_HUMAN, Q9NXA8

Domain: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in

substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind

to malonylated and succinylated substrates and define the specificity (PubMed:22076378)

Similarity: Belongs to the sirtuin family. Class III subfamily

Similarity: Contains 1 deacetylase sirtuin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SIR5_HUMAN, Q9NXA8

Function: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on

target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting:

acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during

fasting. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically

relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro

Catalytic activity: NAD(+) + a malonylprotein = nicotinamide + O-malonyl-ADP-ribose + a protein

Catalytic activity: NAD(+) + a succinylprotein = nicotinamide + O-succinyl-ADP-ribose + a protein

Enzyme regulation: Inhibited by suramin

Biophysicochemical properties: Kinetic parameters: KM=6.1 uM for a synthetic histone H3K9 malonyllysine peptide; KM=5.8

uM for a synthetic histone H3K9 succinyllysine peptide; KM=8.7 uM for a synthetic GLUD1 peptide malonylated at 'Lys-

503'; KM=14 uM for a synthetic GLUD1 peptide succinylated at 'Lys- 503'; KM=150 uM for a synthetic ACSS1 peptide

malonylated at 'Lys- 628'; KM=450 uM for a synthetic ACSS1 peptide succinylated at 'Lys- 628';

Enzyme Number (IUBMB): EC 3.5.1.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SIRT5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT5
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT5 (see all 17):
		hsa-miR-34b* hsa-miR-3607-3p hsa-miR-3133 hsa-miR-192 hsa-miR-186 hsa-miR-215 hsa-miR-548c-3p hsa-miR-576-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SIRT5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRT5 (see all 7) OriGene shRNA RFP: SIRT5 OriGene siRNA: SIRT5
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SIRT5
		Search LifeMap BioReagents cell lines for SIRT5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT5

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003950	NOT NAD+ ADP-ribosyltransferase activity	TAS	17456799
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IDA	--
GO:0036054	protein-malonyllysine demalonylase activity	IDA	--
GO:0036055	protein-succinyllysine desuccinylase activity	IDA	--

SIRT5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SIRT5:

Increased cell death HMECs cel

Increased cell death in breast

Animal Models:
Mouse knock-outs for SIRT5: Sirt5^tm1Fwa Sirt5^tm1.1Ics
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sirt5):

homeostasis/metabolism

normal

SIRT5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

NAD metabolism

NAD metabolism

1.00

NAD metabolism

1.00

Non-homologous end-joining

DNA damage NHEJ mechanisms of DSBs repair

0.36

DNA damage_NHEJ mechanisms of DSBs repair

0.36

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Signaling events mediated by HDAC Class I

Signaling events mediated by HDAC Class I

1.00

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SIRT5

	NAD metabolism
	DNA damage NHEJ mechanisms of DSBs repair

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT5

	p53 Signaling
	SUMO Pathway

2 Cell Signaling Technology (CST) Pathways for SIRT5

	Chromatin Regulation / Acetylation
	Glucose / Energy Metabolism

2 GeneGo (Thomson Reuters) Pathways for SIRT5

	NAD metabolism
	DNA damage NHEJ mechanisms of DSBs repair

1 BioSystems Pathway for SIRT5

Signaling events mediated by HDAC Class I

SIRT5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIRT5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/87 Interacting proteins for SIRT5 (Q9NXA8³ ENSP00000368552⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 87)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT3	Q9NTG7³, ENSP00000372191⁴	I2D: score=1 STRING: ENSP00000372191
RELA	Q04206³, ENSP00000384273⁴	I2D: score=1 STRING: ENSP00000384273
CPS1	P31327³, ENSP00000402608⁴	I2D: score=1 STRING: ENSP00000402608
BRD4	ENSP00000263377⁴	STRING: ENSP00000263377
IARS2	ENSP00000303279⁴	STRING: ENSP00000303279

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006342	chromatin silencing	TAS	10381378
GO:0006471	NOT protein ADP-ribosylation	TAS	17456799
GO:0006476	NOT protein deacetylation	IDA	--
GO:0036047	peptidyl-lysine demalonylation	IDA	--
GO:0036049	peptidyl-lysine desuccinylation	IDA	--

SIRT5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SIRT5 available from Tocris Bioscience About this table

Compound	Action	CAS #
Sirtinol	Selective sirtuin family deacetylase inhibitor	[410536-97-9]
Splitomicin	Sir2p inhibitor	[5690-03-9]

1 HMDB Compound for SIRT5 About this table

Compound	Synonyms	CAS #	PubMed Ids
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

5 DrugBank Compounds for SIRT5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2'-O-Acetyl Adenosine-5-Diphosphoribose	--	--	target	--	17139284 17016423 10592235
Adenosine-5-Diphosphoribose	--	--	target	--	17139284 17016423 10592235
Nicotinamide	--	98-92-0	target	--	17139284 17016423 10592235
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	17139284 17016423 10592235
Suramin	Bayer 205 (see all 6)	145-63-1	target	inhibitor	17355872

Search CenterWatch for drugs/clinical trials and news about SIRT5 / SIR5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIRT5 gene (4 alternative transcripts):

NM_001193267.2 NM_001242827.1 NM_012241.4 NM_031244.3

Unigene Clusters for SIRT5:

Sirtuin 5

Hs.567431 [show with all ESTs], Hs.594133 [show with all ESTs]

Unigene Representative Sequences: NM_012241, AK094269

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379262(uc003naw.3) ENST00000379250(uc003nax.3 uc003nay.3)

ENST00000359782(uc011dit.2) ENST00000397350

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SIRT5 Browse OriGene MicroRNA Expression Plasmids
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		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT5 (see all 17):
		hsa-miR-34b* hsa-miR-3607-3p hsa-miR-3133 hsa-miR-192 hsa-miR-186 hsa-miR-215 hsa-miR-548c-3p hsa-miR-576-5p

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT5

Additional cDNA sequence:

AK094269.1 BC064478.1

16 DOTS entries:

DT.212593 DT.409466 DT.99974806 DT.95143890 DT.101955149 DT.121393611 DT.95262507 DT.121393774

DT.99995211 DT.100791969 DT.100767818 DT.121393691 DT.95113447 DT.95212233 DT.97766929 DT.91744595

24/127 AceView cDNA sequences (see all 127):

AI089886 CR606976 BE350936 CR595911 CF140176 AI419476 BI061941 AI401136

BQ006251 CA412315 BE217845 BF434883 CR617335 CA406695 AA721145 CR623350

AA732428 W68575 AA811503 AL704940 BE379900 BQ230580 AA765055 CR600455

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT5 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·	14b	·	14c	^	15a	·	15b
SP1:							-																-								-		-		-		-
SP2:					-		-						-										-								-		-		-		-
SP3:																							-								-		-
SP4:
SP5:					-		-

ECgene alternative splicing isoforms for SIRT5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIRT5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATGAAAC

About this image
See SIRT5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRT5

SOURCE GeneReport for Unigene clusters: Hs.567431 Hs.594133

UniProtKB/Swiss-Prot: SIR5_HUMAN, Q9NXA8

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for SIRT5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SIRT5 gene from 10/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SIRT5¹	sirtuin 5	73.99(n) 77.7(a)		420834 XM_418925.3 XP_418925.3
lizard (Anolis carolinensis)	Reptilia	SIRT6⁶ SIRT1⁶ (see all 7)	--	9(a) 8(a) (see all 7)	possible ortholog possible ortholog (see all 7)	AAWZ02041818(3377-5222) GL343215.1(1274117-1291832)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15494²	Xenopus laevis transcribed sequence with weak similarity more	75.03(n)		CA973198.1
zebrafish (Danio rerio)	Actinopterygii	CK353135.1²	--	74.94(n)		CK353135.1
fruit fly (Drosophila melanogaster)	Insecta	Sir2⁶ Sirt7⁶ (see all 5)	Sirt7 (see all 5)	8(a) 8(a) (see all 5)	possible ortholog possible ortholog (see all 5)	2L(13165551-13169551) 3R(24881654-24884926)
worm (Caenorhabditis elegans)	Secernentea	sir-2.3⁶ sir-2.2⁶ (see all 4)	yeast SIR related family member (sir-2.2) (see all 4)	22(a) 21(a) (see all 4)	possible ortholog possible ortholog (see all 4)	X(13331947-13333620) X(13328189-13331175)
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_ABL004W¹	ABL004Wp	45.02(n) 40.3(a)		4619035 NM_208296.1 NP_982943.1
thale cress (Arabidopsis thaliana)	eudicotyledons	SRT2⁶ SRT1⁶	sirtuin 1	18(a) 12(a)	possible ortholog possible ortholog	5(2871377-2873789) 5(22567222-22570963)
rice (Oryza sativa)	Liliopsida	-- --	transcriptional regulator Sir2 family protein, put... transcriptional regulator Sir2 family protein, put...	18(a) 12(a)	possible ortholog possible ortholog	12(4031200-4035956) 4(11306929-11319334)
E. coli (Escherichia coli)	Gamma proteobacteria	cobB⁶	deacetylase of acs and cheY, regulates chemotaxis	35(a)	1 ↔ 1	Chromosome(1178854-1179582)

ENSEMBL Gene Tree for SIRT5 (if available)
TreeFam Gene Tree for SIRT5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIRT5 gene

SIRT2² SIRT4² SIRT3²

SIRT5 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for SIRT5
PGOHUM00000244750 PGOHUM00000260404 PGOHUM00000249355

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7764534^1,2	A	--	13555854(+)	`acacaC/Tataca`	1	--	int¹		0	--	--	--	--
rs77341813^1,2	F,	--	13572782(+)	`CTACAT/CATCGG`	3	--	us2k¹		1		WA	118
rs77068038^1,2		--	13572842(+)	`TCCAAC/TTGAAA`	3	--	us2k¹		0	--	--	--	--
rs183323970^1,2		--	13573085(+)	`GAGAAG/TGAGTA`	4	--	us2k¹		0	--	--	--	--
rs189074031^1,2		--	13573115(+)	`CCCTTC/TTTCCA`	4	--	us2k¹		0	--	--	--	--
rs3807053^1,2	C,F,H,	--	13573138(+)	`GCTGGG/CGAATT`	4	--	us2k¹		12		EA NS NA WA	2270
rs191826556^1,2		--	13573299(+)	`ATAATA/GATGTA`	4	--	us2k¹		0	--	--	--	--
rs184017956^1,2		--	13573439(+)	`GTTACC/TTATAG`	4	--	us2k¹		0	--	--	--	--
rs3840544^1,2	C,	--	13573459(+)	`CTAGG-/AAAAAA`	4	--	us2k¹		1		CSA	2
rs200580151^1,2		--	13573467(+)	`AAAAA-/TCAAAC`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIRT5 (13574792 - 13614790 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIRT5: --
Human Gene Mutation Database (HGMD): SIRT5

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIRT5 for disorders           About GeneDecksing

OMIM gene information: 604483    OMIM disorders: --

6 diseases for SIRT5:    About MalaCards

intrahepatic cholangiocarcinoma cholangiocarcinoma schizophrenia tuberculosis

malaria mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: SIRT5 (4 documents)

Export disorders for SIRT5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SIRT5 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SIRT5)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)^{1, 2, 3} Frye R.A. (1999)
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PubMed id 18680753)^{1, 2, 9} Schlicker C....Steegborn C. (2008)
The first identification of lysine malonylation substrates and its regulatory enzyme. (PubMed id 21908771)^{1, 2} Peng C.... Zhao Y. (2011)
Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms. (PubMed id 21143562)^{1, 2} Matsushita N....Yanagi S. (2011)
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. (PubMed id 22076378)^{1, 2} Du J.... Lin H. (2011)
Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin. (PubMed id 17355872)^{2, 7} Schuetz A....Plotnikov A.N. (2007)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)^{1, 2} Michishita E.... Horikawa I. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23408	HGNC: 14933	AceView: SIRT5	Ensembl:ENSG00000124523	euGenes: HUgn23408
ECgene: SIRT5	H-InvDB: SIRT5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SIRT5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SIRT5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SIRT5 gene:
Search GeneIP for patents involving SIRT5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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