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SIRT4 Gene

protein-coding   GIFtS: 59
GCID: GC12P120740

Sirtuin 4

(Previous names: sirtuin (silent mating type information regulation 2, S....)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sirtuin 41 2     Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae,
Homolog) 41
SIR2L42 3 5     NAD-Dependent Protein Deacetylase Sirtuin-42
Regulatory Protein SIR2 Homolog 42 3     Sir2-Like 42
NAD-Dependent ADP-Ribosyltransferase Sirtuin-42 3     Sirtuin Type 42
SIR2-Like Protein 42 3     EC 2.4.2.-3
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S.
Cerevisiae)1
     EC 3.5.1.-3

External Ids:    HGNC: 149321   Entrez Gene: 234092   Ensembl: ENSG000000891637   OMIM: 6044825   UniProtKB: Q9Y6E73   
ORGUL members:         

Export aliases for SIRT4 gene to outside databases

Previous GC identifers: GC12P119613 GC12P120266 GC12P120522 GC12P119152 GC12P119203 GC12P117748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIRT4 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class IV of the sirtuin family. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIRT4 Gene:
SIRT4 (sirtuin 4) is a protein-coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD-dependent protein deacetylase activity. An important paralog of this gene is SIRT1.

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7
Function: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase.
Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting
GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono
ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting
GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In
response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a
tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD,
inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion

summary for SIRT4 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIRT4 gene promoter:
         STAT1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXJ2 (long isoform)   STAT3   c-Myb   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT4 promoter sequence
   Search Chromatin IP Primers for SIRT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SIRT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120740:  view genomic region     (about GC identifiers)

Start:
120,740,119 bp from pter      End:
120,751,052 bp from pter
Size:
10,934 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-4 precursor  
Size: 314 amino acids; 35188 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with GLUD1, IDE and SLC25A5
Miscellaneous: Expression is down-regulated in a number of cancers, while overexpression reduces cell
proliferation, transformation, and tumor development (PubMed:23562301, PubMed:23663782)
Miscellaneous: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side
reaction of the deacetylase activity and may not be physiologically relevant (By similarity)
Sequence caution: Sequence=AAB95634.1; Type=Erroneous gene model prediction;
Secondary accessions: O43346 Q32M33

Explore the universe of human proteins at neXtProt for SIRT4: NX_Q9Y6E7

Explore proteomics data for SIRT4 at MOPED


See SIRT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036372.1  
ENSEMBL proteins: 
 ENSP00000444838   ENSP00000202967  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR026587 Sirtuin_class_II
 IPR026591 Sirtuin_cat_small_dom
 IPR003000 Sirtuin
 IPR026590 Ssirtuin_cat_dom

Graphical View of Domain Structure for InterPro Entry Q9Y6E7

ProtoNet protein and cluster: Q9Y6E7

1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7
Similarity: Belongs to the sirtuin family. Class II subfamily
Similarity: Contains 1 deacetylase sirtuin-type domain


Find genes that share domains with SIRT4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SIR4_HUMAN, Q9Y6E7
Function: Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase.
Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting
GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono
ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting
GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In
response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a
tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD,
inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion
Catalytic activity: NAD(+) + a protein = nicotinamide + an N-(ADP-D-ribosyl)-protein
Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

     Enzyme Numbers (IUBMB): EC 2.4.2.-1 EC 3.5.1.-1

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003950NAD+ ADP-ribosyltransferase activity TAS17456799
GO:0005515protein binding IPI16959573
GO:0034979NOT NAD-dependent protein deacetylase activity IDA17715127
GO:0046872metal ion binding IEA--
GO:0070403NAD+ binding IEA--
     
Find genes that share ontologies with SIRT4           About GenesLikeMe


Phenotypes:
     1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Sirt4):
 normal 

Find genes that share phenotypes with SIRT4           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Sirt4tm1Fwa for SIRT4

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIRT4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIRT4

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miRNA
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miRTarBase miRNAs that target SIRT4:
hsa-mir-103a-3p (MIRT027077), hsa-mir-26b-5p (MIRT029386), hsa-mir-16-5p (MIRT031656), hsa-mir-148b-3p (MIRT043594)

Block miRNA regulation of human, mouse, rat SIRT4 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate SIRT4:
hsa-miR-374b* hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-339-5p
SwitchGear 3'UTR luciferase reporter plasmidSIRT4 3' UTR sequence
Inhib. RNA
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Gene Editing
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Sino Biological Human cDNA Clone for SIRT4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT4
Addgene plasmids for SIRT4 

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SIR4_HUMAN, Q9Y6E7: Mitochondrion matrix
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
nucleus2
peroxisome1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA16079181
GO:0005759mitochondrial matrix IDA16959573

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SIRT4 About    
See pathways by source

SuperPathContained pathways About
1p53 Signaling
p53 Signaling0.38
p53 Pathway0.38
2Nicotinate and nicotinamide metabolism
NAD metabolism0.43
3Non-homologous end-joining
DNA damage NHEJ mechanisms of DSBs repair0.37
44-1BB Pathway
SUMO Pathway0.30
5Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class I

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIRT4
    p53 Signaling
SUMO Pathway

2 GeneGo (Thomson Reuters) Pathways for SIRT4
    NAD metabolism
DNA damage NHEJ mechanisms of DSBs repair

1 BioSystems Pathway for SIRT4
    Signaling events mediated by HDAC Class I

1 Sino Biological Pathway for SIRT4
    p53 Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SIRT4
Interactions:

    Search GeneGlobe Interaction Network for SIRT4

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

Selected Interacting proteins for SIRT4 (Q9Y6E71, 3 ENSP000002029674) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
SLC25A5P051411, 3, ENSP000003606714EBI-2606540,EBI-355133 I2D: score=2 STRING: ENSP00000360671
SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
IDEP147353, ENSP000002659864I2D: score=2 STRING: ENSP00000265986
SLC25A6P122363, ENSP000003708084I2D: score=2 STRING: ENSP00000370808
ENAHQ8N8S73I2D: score=4 
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Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006342chromatin silencing TAS10381378
GO:0006471protein ADP-ribosylation TAS17456799
GO:0006541glutamine metabolic process ISS--
GO:0006974cellular response to DNA damage stimulus ISS--
GO:0034983peptidyl-lysine deacetylation ISS--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
6 ApexBio Compounds for SIRT4     About this table
CompoundAction CAS #
EX 527 (SEN0014196)novel, potential, and specific small-molecule inhibitor of SIRT1[49843-98-3]
Sirtinolspecific SIRT1 and SIRT2 inhibitor[410536-97-9]
sirtuin modulatorsirtuin modulator[1093403-33-8]
SRT1720activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
Tenovin-3Tenovin-3 [1011301-27-1]
Tenovin-6a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

Compounds for SIRT4 available from Tocris Bioscience    About this table
CompoundAction CAS #
SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
EX 527Selective SIRT1 inhibitor[49843-98-3]
AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
SplitomicinSir2p inhibitor[5690-03-9]
AGK 2Selective SIRT2 inhibitor[304896-28-4]

1 HMDB Compound for SIRT4    About this table
CompoundSynonyms CAS #PubMed Ids
NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SIRT4 gene: 
NM_012240.2  

Unigene Cluster for SIRT4:

Sirtuin 4
Hs.50861  [show with all ESTs]
Unigene Representative Sequence: BC034736
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000536460 ENST00000202967(uc001tyc.3) ENST00000537892
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  QuantiFast Probe-based Assays in human, mouse, rat SIRT4

Additional mRNA sequence: 

AF083109.1 BC034736.1 BC109319.3 BC109320.3 

3 DOTS entries:

DT.411590  DT.99963190  DT.121151837 

Selected AceView cDNA sequences (see all 27):

BC034736 BM674605 BM713962 AI936687 CB139856 AW025599 BI764258 BF591913 
NM_012240 BF589963 AF083109 BM467963 AA412672 AA135913 AA405279 BQ708274 
AA156947 N80020 AI264615 AI910696 W63584 AI192403 W30903 AA247909 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT4    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1:                                                      
SP2:                          -                           
SP3:                                                      
SP4:              -                                       


ECgene alternative splicing isoforms for SIRT4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SIRT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGACCACAG
SIRT4 Expression
About this image


SIRT4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebellum
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Liver (Hepatobiliary System)
         Hepatocytes Liver Lobule
SIRT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SIRT4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.50861

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7
Tissue specificity: Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing
beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes
and fetal thymus

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for SIRT4 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Sirt41 , 5 sirtuin 4 (silent mating type information regulation more5
sirtuin 41
83.23(n)1
87.01(a)1
  5 (56.10 cM)5
753871  NM_001167691.11  NP_001161163.11 
 1154780105 
chicken
(Gallus gallus)
Aves SIRT41 sirtuin 4 73.33(n)
75.36(a)
  416981  XM_004934395.1  XP_004934452.1 
lizard
(Anolis carolinensis)
Reptilia SIRT46
sirtuin 4
61(a)
1 ↔ 1
GL343338.1(1146-5952)
African clawed frog
(Xenopus laevis)
Amphibia AW643248.12   -- 74.45(n)    AW643248.1 
zebrafish
(Danio rerio)
Actinopterygii sirt41 sirtuin 4 64.22(n)
65.38(a)
  791628  NM_001005988.1  NP_001005988.1 
fruit fly
(Drosophila melanogaster)
Insecta CG31873
Sirt41
Sirt41 49(a)3
51.67(n)1
48.67(a)1
  5A103
314801  NM_132013.21  NP_572241.21 
worm
(Caenorhabditis elegans)
Secernentea sir-2.21 , 3 SIR3
sir-2.21
49(a)
(best of 2)3
50.78(n)1
50.18(a)1
  X(13364196-13366297)3
1814551  NM_001270289.11  NP_001257218.11 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST16
SIR26
NAD(+)-dependent histone deacetylase; essential su...
Conserved NAD+ dependent histone deacetylase of th...
13(a)
11(a)
many ↔ many
many ↔ many
XV(200368-201879) YOL068C
IV(376757-378445) YDL042C
thale cress
(Arabidopsis thaliana)
eudicotyledons SRT21 SRT2 50.61(n)
45.62(a)
  830782  NM_001085081.1  NP_001078550.1 
rice
(Oryza sativa)
Liliopsida Os12g01798001 Os12g0179800 50.54(n)
46.43(a)
  4351669  NM_001072842.1  NP_001066310.1 


ENSEMBL Gene Tree for SIRT4 (if available)
TreeFam Gene Tree for SIRT4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SIRT4 gene
SIRT12  SIRT52  

Find genes that share paralogs with SIRT4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SIRT4 (see all 396)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1436548681,2
--120738136(+) TACTAA/TATGGT 1 -- us2k10--------
rs1471809081,2
--120738307(+) GCAGTC/TGCACA 1 -- us2k10--------
rs1395638081,2
--120738340(+) ATCTCC/TTGGGC 1 -- us2k10--------
rs557985751,2
--120738492(+) GTGATC/TCTCCT 1 -- us2k10--------
rs354072251,2
C,F--120738605(+) CCCTGC/ATGGCC 1 -- us2k14Minor allele frequency- A:0.06NA 126
rs774829781,2
C,F--120738730(+) CCCTGG/TGAGTG 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs2006026701,2
--120738765(+) TTAAT-/AAAAAA 1 -- us2k10--------
rs1455000411,2
--120738863(+) CATCAC/TTTTTG 1 -- us2k10--------
rs24642971,2
C,F--120738885(-) ggcgtA/Gagcca 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs1381941451,2
C--120738902(+) CCCAGC/TACTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for SIRT4 (120740119 - 120751052 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SIRT4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv518764CNV Loss19592680
nsv832530CNV Loss17160897
nsv899555CNV Loss21882294
nsv899556CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SIRT4
DNA2.0 Custom Variant and Variant Library Synthesis for SIRT4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604482    OMIM disorders: --


Find genes that share disorders with SIRT4           About GenesLikeMe

Genetic Association Database (GAD): SIRT4
Human Genome Epidemiology (HuGE) Navigator: SIRT4 (2 documents)

Export disorders for SIRT4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SIRT4 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with SIRT4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)1, 2, 3 Frye R.A. (Biochem. Biophys. Res. Commun. 1999)
  2. Regulation of insulin secretion by SIRT4, a mitochondrial ADP- ribosyltransferase. (PubMed id 17715127)1, 2, 9 Ahuja N.... Verdin E. (J. Biol. Chem. 2007)
  3. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. (PubMed id 23663782)1, 2 Csibi A....Blenis J. (Cell 2013)
  4. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1, 4 Reiling E....Dekker J.M. (Eur. J. Hum. Genet. 2009)
  5. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (PubMed id 16959573)1, 2 Haigis M.C.... Guarente L. (Cell 2006)
  6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
  7. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2 Michishita E.... Horikawa I. (Mol. Biol. Cell 2005)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  10. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. (PubMed id 23562301)2 Jeong S.M.... Haigis M.C. (Cancer Cell 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23409 HGNC: 14932 AceView: SIRT4 Ensembl:ENSG00000089163 euGenes: HUgn23409
ECgene: SIRT4 H-InvDB: SIRT4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SIRT4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SIRT4 gene:
Search GeneIP for patents involving SIRT4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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