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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIRT4 Gene

protein-coding   GIFtS: 58
GCID: GC12P120740

Sirtuin 4

(Previous names: sirtuin (silent mating type information regulation 2, S....)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sirtuin 41 2     Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae,
Homolog) 41
SIR2L42 3 5     NAD-Dependent Protein Deacetylase Sirtuin-42
Regulatory Protein SIR2 Homolog 42 3     Sir2-Like 42
NAD-Dependent ADP-Ribosyltransferase Sirtuin-42 3     Sirtuin Type 42
SIR2-Like Protein 42 3     EC 2.4.2.-3
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S.
Cerevisiae)1
     EC 3.5.1.-3

External Ids:    HGNC: 149321   Entrez Gene: 234092   Ensembl: ENSG000000891637   OMIM: 6044825   UniProtKB: Q9Y6E73   

Export aliases for SIRT4 gene to outside databases

Previous GC identifers: GC12P119613 GC12P120266 GC12P120522 GC12P119152 GC12P119203 GC12P117748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRT4 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class IV of the sirtuin family. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIRT4 Gene: 
SIRT4 (sirtuin 4) is a protein-coding gene. Diseases associated with SIRT4 include hyperinsulinism, and tuberculosis, and among its related super-pathways are p53 Signaling and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD-dependent protein deacetylase activity. An important paralog of this gene is SIRT2.

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7
Function: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target
proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no
detectable protein deacetylase activity

summary for SIRT4 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIRT4 gene promoter:
         STAT1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   FOXJ2 (long isoform)   STAT3   c-Myb   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIRT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SIRT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120740:  view genomic region     (about GC identifiers)

Start:
120,740,119 bp from pter      End:
120,751,052 bp from pter
Size:
10,934 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-4 precursor  
Size: 314 amino acids; 35188 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with GLUD1, IDE and SLC25A5
Subcellular location: Mitochondrion matrix
Miscellaneous: The reported ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the
deacetylase activity and may not be physiologically relevant (By similarity)
Sequence caution: Sequence=AAB95634.1; Type=Erroneous gene model prediction;
Secondary accessions: O43346 Q32M33

Explore the universe of human proteins at neXtProt for SIRT4: NX_Q9Y6E7

Explore proteomics data for SIRT4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6E7

  • SIRT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIRT4 Protein Expression
    REFSEQ proteins: NP_036372.1  
    ENSEMBL proteins: 
     ENSP00000444838   ENSP00000202967  

    Human Recombinant Protein Products for SIRT4: 
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    OriGene Protein Over-expression Lysate for SIRT4
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    Novus Biologicals SIRT4 Proteins
    Novus Biologicals SIRT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SIRT4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA16079181
    GO:0005759mitochondrial matrix IDA16959573

    SIRT4 for ontologies           About GeneDecksing



    SIRT4 Antibody Products: 
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    ThermoFisher Antibody for SIRT4
    LSBio Antibodies in human, mouse, rat for SIRT4 

    Assay Products for SIRT4: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SIRT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SIRT4 
    Cloud-Clone Corp. CLIAs for SIRT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003000 Sirtuin
     IPR026587 Sirtuin_ClassII
     IPR026590 Ssirtuin_cat_dom
     IPR026591 Sirtuin_cat_small_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6E7

    ProtoNet protein and cluster: Q9Y6E7

    1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7
    Similarity: Belongs to the sirtuin family. Class II subfamily
    Similarity: Contains 1 deacetylase sirtuin-type domain


    SIRT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIR4_HUMAN, Q9Y6E7
    Function: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target
    proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no
    detectable protein deacetylase activity
    Catalytic activity: NAD(+) + a protein = nicotinamide + an N-(ADP-D-ribosyl)-protein
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

         Enzyme Numbers (IUBMB): EC 2.4.2.-1 EC 3.5.1.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NAD+ ADP-ribosyltransferase activity TAS17456799
    GO:0005515protein binding IPI16959573
    GO:0008270zinc ion binding ----
    GO:0034979NOT NAD-dependent protein deacetylase activity IDA17715127
    GO:0046872metal ion binding IEA--
         
    SIRT4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sirt4):
     normal 

    SIRT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sirt4tm1Fwa for SIRT4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIRT4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIRT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRT4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIRT4 

    miRNA
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    hsa-miR-374b* hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidSIRT4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SIRT4

    Clone
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    GenScript: all cDNA clones in your preferred vector: SIRT4 (NM_012240)
    Sino Biological Human cDNA Clone for SIRT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT4
    Sirion Biotech Customized lentivirus for stable overexpression of SIRT4 
                         Customized lentivirus expression plasmids for stable overexpression of SIRT4 

    Cell Line
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    Search LifeMap BioReagents cell lines for SIRT4
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIRT4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1p53 Pathway
    p53 Signaling0.38
    p53 Pathway0.38
    2NAD metabolism
    NAD metabolism0.43
    3Non-homologous end-joining
    DNA damage NHEJ mechanisms of DSBs repair0.37
    44-1BB Pathway
    SUMO Pathway0.30
    5Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for SIRT4
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT4
        p53 Signaling
    SUMO Pathway

    2 GeneGo (Thomson Reuters) Pathways for SIRT4
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    1 BioSystems Pathway for SIRT4
        Signaling events mediated by HDAC Class I

    1 Sino Biological Pathway for SIRT4 
        p53 Pathway



    SIRT4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIRT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/12 Interacting proteins for SIRT4 (Q9Y6E71, 3 ENSP000002029674) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC25A5P051411, 3, ENSP000003606714EBI-2606540,EBI-355133 I2D: score=2 STRING: ENSP00000360671
    SIRT3Q9NTG73, ENSP000003721914I2D: score=2 STRING: ENSP00000372191
    IDEP147353, ENSP000002659864I2D: score=2 STRING: ENSP00000265986
    SLC25A6P122363, ENSP000003708084I2D: score=2 STRING: ENSP00000370808
    ENAHQ8N8S73I2D: score=4 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006342chromatin silencing TAS10381378
    GO:0006471protein ADP-ribosylation TAS17456799
    GO:0006541glutamine metabolic process ISS--
    GO:0006974response to DNA damage stimulus ISS--
    GO:0034983peptidyl-lysine deacetylation ISS--

    SIRT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SIRT4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
    SplitomicinSir2p inhibitor[5690-03-9]
    AGK 2Selective SIRT2 inhibitor[304896-28-4]

    1 HMDB Compound for SIRT4    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    Search CenterWatch for drugs/clinical trials and news about SIRT4 / SIR4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIRT4 gene: 
    NM_012240.2  

    Unigene Cluster for SIRT4:

    Sirtuin 4
    Hs.50861  [show with all ESTs]
    Unigene Representative Sequence: BC034736
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536460 ENST00000202967(uc001tyc.3) ENST00000537892
    miRNA
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    hsa-miR-374b* hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidSIRT4 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT4
    Clone
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    GenScript: all cDNA clones in your preferred vector: SIRT4 (NM_012240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT4
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    Additional mRNA sequence: 

    AF083109.1 BC034736.1 BC109319.3 BC109320.3 

    3 DOTS entries:

    DT.411590  DT.99963190  DT.121151837 

    24/27 AceView cDNA sequences (see all 27):

    BC034736 BM713962 BM674605 BI764258 BM467963 NM_012240 BF589963 AF083109 
    AW025599 AI936687 AA412672 CB139856 BF591913 AA135913 W63584 BQ708274 
    AI192403 AA405279 AI910696 N80020 AA156947 AI264615 W30903 AA247909 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
    SP1:                                                      
    SP2:                          -                           
    SP3:                                                      
    SP4:              -                                       


    ECgene alternative splicing isoforms for SIRT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIRT4 expression in normal human tissues (normalized intensities)      SIRT4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGACCACAG
    SIRT4 Expression
    About this image


    SIRT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             posterior singulate   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Spinal Cord (Nervous System)
             Superior Cervical Ganglion   

    See SIRT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIRT4

    SOURCE GeneReport for Unigene cluster: Hs.50861

    UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7
    Tissue specificity: Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing
    beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes
    and fetal thymus

        SABiosciences Custom PCR Arrays for SIRT4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SIRT4 gene from 10/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirt41 , 5 sirtuin 4 (silent mating type information regulation more1, 5 83.39(n)1
    87.3(a)1
      5 (56.10 cM)5
    753871  NM_001167691.11  NP_001161163.11 
     1154780105 
    chicken
    (Gallus gallus)
    Aves SIRT41 sirtuin 4 70.65(n)
    71.1(a)
      416981  XM_415273.3  XP_415273.3 
    lizard
    (Anolis carolinensis)
    Reptilia SIRT46
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343338.1(1146-5952)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW643248.12   -- 74.45(n)    AW643248.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1035391 zgc:103539 64.22(n)
    65.38(a)
      791628  NM_001005988.1  NP_001005988.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31873
    Sirt41
    CG3187-PA1 49(a)3
    52.88(n)1
    50(a)1
      5A103
    314801  NM_132013.21  NP_572241.21 
    worm
    (Caenorhabditis elegans)
    Secernentea sir-2.21 , 3 SIR3
    Protein SIR-2.21
    49(a)
    (best of 2)3
    50.78(n)1
    50.18(a)1
      X(13364196-13366297)3
    1814551  NM_001029502.11  NP_001024673.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HST16
    SIR26
    NAD(+)-dependent histone deacetylase; essential su...
    Conserved NAD+ dependent histone deacetylase of th...
    12(a)
    10(a)
    many ↔ many
    many ↔ many
    XV(200368-201879)
    IV(376757-378445)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SRT21 sirtuin 2 50.55(n)
    45.79(a)
      830782  NM_001085081.1  NP_001078550.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01798001 hypothetical protein 50.54(n)
    46.43(a)
      4351669  NM_001072842.1  NP_001066310.1 


    ENSEMBL Gene Tree for SIRT4 (if available)
    TreeFam Gene Tree for SIRT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIRT4 gene
    SIRT22  SIRT32  SIRT52  

    SIRT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/396 SNPs in SIRT4 are shown (see all 396)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436548681,2
    --120738136(+) TACTAA/TATGGT 1 -- us2k10--------
    rs1471809081,2
    --120738307(+) GCAGTC/TGCACA 1 -- us2k10--------
    rs1395638081,2
    --120738340(+) ATCTCC/TTGGGC 1 -- us2k10--------
    rs557985751,2
    --120738492(+) GTGATC/TCTCCT 1 -- us2k10--------
    rs354072251,2
    C,F--120738605(+) CCCTGC/ATGGCC 1 -- us2k14Minor allele frequency- A:0.06NA 126
    rs774829781,2
    C,F--120738730(+) CCCTGG/TGAGTG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs2006026701,2
    --120738765(+) TTAAT-/AAAAAA 1 -- us2k10--------
    rs1455000411,2
    --120738863(+) CATCAC/TTTTTG 1 -- us2k10--------
    rs24642971,2
    C,F--120738885(-) ggcgtA/Gagcca 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1381941451,2
    C--120738902(+) CCCAGC/TACTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SIRT4 (120740119 - 120751052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SIRT4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518764CNV Loss19592680
    nsv832530CNV Loss17160897
    nsv899555CNV Loss21882294
    nsv899556CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604482    OMIM disorders: --

    5 diseases for SIRT4:    About MalaCards
    hyperinsulinism    tuberculosis    neuropathy    diabetes mellitus
    pancreatitis


    SIRT4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIRT4
    Human Genome Epidemiology (HuGE) Navigator: SIRT4 (2 documents)

    Export disorders for SIRT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIRT4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SIRT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)1, 2, 3 Frye R.A. (1999)
    2. Regulation of insulin secretion by SIRT4, a mitochondrial ADP- ribosyltransferase. (PubMed id 17715127)1, 2, 9 Ahuja N.... Verdin E. (2007)
    3. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1, 4 Reiling E....Dekker J.M. (2009)
    4. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (PubMed id 16959573)1, 2 Haigis M.C.... Guarente L. (2006)
    5. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    6. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2 Michishita E.... Horikawa I. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. (PubMed id 23663782)1 Csibi A....Blenis J. (2013)
    9. Sirtuin-4 modulates sensitivity to induction of the mi tochondrial permeability transition pore. (PubMed id 23044393)1 Verma M....Pastorino J.G. (2013)
    10. SIRT3 functions in the nucleus in the control of stres s-related gene expression. (PubMed id 23045395)1 Iwahara T....Reinberg D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23409 HGNC: 14932 AceView: SIRT4 Ensembl:ENSG00000089163 euGenes: HUgn23409
    ECgene: SIRT4 H-InvDB: SIRT4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIRT4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIRT4 gene:
    Search GeneIP for patents involving SIRT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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