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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIRT4 Gene

protein-coding GIFtS: 57
GCID: GC12P120740

sirtuin 4

(Previous names: sirtuin (silent mating type information regulation 2, S....)

Explore 6 diseases affiliated with
SIRT4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sirtuin 4¹ ²		Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 4¹
SIR2L4¹ ² ³ ⁵		NAD-Dependent Protein Deacetylase Sirtuin-4²
Regulatory Protein SIR2 Homolog 4² ³		Sir2-Like 4²
NAD-Dependent ADP-Ribosyltransferase Sirtuin-4² ³		Sirtuin Type 4²
SIR2-Like Protein 4² ³		EC 2.4.2.-³
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S. Cerevisiae)¹		EC 3.5.1.-³

External Ids:	HGNC: 14932¹	Entrez Gene: 23409²	Ensembl: ENSG00000089163⁷	OMIM: 604482⁵	UniProtKB: Q9Y6E7³

Export aliases for SIRT4 gene to outside databases

Previous GC identifers: GC12P119613 GC12P120266 GC12P120522 GC12P119152 GC12P119203 GC12P117748

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRT4:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the

sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human

sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing

and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory

proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the

sirtuin family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7

Function: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target

proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no

detectable protein deacetylase activity

summary for SIRT4:

Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes

closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or

nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups

from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,

sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and

mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of

transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible

antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process

through their role in resistance to cellular stress.

Gene Wiki entry for SIRT4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIRT4 gene promoter:
STAT1 ATF-2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 FOXJ2 (long isoform) STAT3 c-Myb FOXJ2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIRT4 promoter sequence

Search SABiosciences Chromatin IP Primers for SIRT4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31

SIRT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P120740: view genomic region (about GC identifiers)

Start:	120,740,119 bp from pter	End:	120,751,052 bp from pter
Size:	10,934 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7 (See protein sequence)

Recommended Name: NAD-dependent protein deacetylase sirtuin-4 precursor

Size: 314 amino acids; 35188 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Interacts with GLUD1, IDE and SLC25A5

Subcellular location: Mitochondrion matrix

Miscellaneous: The reported ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the

deacetylase activity and may not be physiologically relevant (By similarity)

Sequence caution: Sequence=AAB95634.1; Type=Erroneous gene model prediction;

Secondary accessions: O43346 Q32M33

Explore the universe of human proteins at neXtProt for SIRT4: NX_Q9Y6E7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6E7

SIRT4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_036372.1

ENSEMBL proteins:

ENSP00000444838 ENSP00000202967

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SIRT4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	16079181
GO:0005759	mitochondrial matrix	IDA	17715127

SIRT4 for ontologies About GeneDecksing

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	ThermoFisher Antibody for SIRT4

Assay Products for SIRT4:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SIRT4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIRT4 for domains About GeneDecksing

4 InterPro domains/families:

IPR003000 Sirtuin

IPR026587 Sirtuin_ClassII

IPR026590 Ssirtuin_cat_dom

IPR026591 Sirtuin_cat_small_dom

Graphical View of Domain Structure for InterPro Entry Q9Y6E7

ProtoNet protein and cluster: Q9Y6E7

1 Blocks protein family: IPB003000 Silent information regulator protein Sir2

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7

Similarity: Belongs to the sirtuin family. Class II subfamily

Similarity: Contains 1 deacetylase sirtuin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7

Function: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target

proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down-regulates insulin secretion. Has no

detectable protein deacetylase activity

Catalytic activity: NAD(+) + a protein = nicotinamide + an N-(ADP-D-ribosyl)-protein

Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

Enzyme Numbers (IUBMB): EC 2.4.2.-¹ EC 3.5.1.-¹

miRNA Products:		OriGene 3'-UTR Clone: SIRT4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT4
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT4:
		hsa-miR-374b* hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-339-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SIRT4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		Search LifeMap BioReagents cell lines for SIRT4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT4

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003950	NAD+ ADP-ribosyltransferase activity	TAS	17456799
GO:0005515	protein binding	IPI	17715127
GO:0008270	zinc ion binding	IEA	--
GO:0034979	NOT NAD-dependent protein deacetylase activity	IDA	17715127
GO:0070403	NAD+ binding	IEA	--

SIRT4 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Sirt4^tm1Fwa for SIRT4
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Sirt4):

normal

SIRT4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

NAD metabolism

NAD metabolism

1.00

NAD metabolism

1.00

Non-homologous end-joining

DNA damage_NHEJ mechanisms of DSBs repair

0.36

DNA damage NHEJ mechanisms of DSBs repair

0.36

Signaling events mediated by HDAC Class I

Signaling events mediated by HDAC Class I

1.00

Chks in Checkpoint Regulation

p53 Signaling

0.32

4-1BB Pathway

SUMO Pathway

0.30

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SIRT4

	NAD metabolism
	DNA damage NHEJ mechanisms of DSBs repair

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT4

	p53 Signaling
	SUMO Pathway

2 GeneGo (Thomson Reuters) Pathways for SIRT4

	NAD metabolism
	DNA damage NHEJ mechanisms of DSBs repair

1 BioSystems Pathway for SIRT4

Signaling events mediated by HDAC Class I

SIRT4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SIRT4

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/12 Interacting proteins for SIRT4 (Q9Y6E7^{1, 3} ENSP00000202967⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC25A5	P05141¹^,³, ENSP00000360671⁴	EBI-2606540,EBI-355133 I2D: score=2 STRING: ENSP00000360671
SIRT3	Q9NTG7³, ENSP00000372191⁴	I2D: score=2 STRING: ENSP00000372191
IDE	P14735³, ENSP00000265986⁴	I2D: score=2 STRING: ENSP00000265986
SLC25A6	P12236³, ENSP00000370808⁴	I2D: score=2 STRING: ENSP00000370808
ENAH	Q8N8S7³	I2D: score=4

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006342	chromatin silencing	TAS	10381378
GO:0006471	protein ADP-ribosylation	TAS	17456799
GO:0006476	protein deacetylation	--	--
GO:0046676	negative regulation of insulin secretion	IMP	17715127

SIRT4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SIRT4 available from Tocris Bioscience About this table

Compound	Action	CAS #
Sirtinol	Selective sirtuin family deacetylase inhibitor	[410536-97-9]
Splitomicin	Sir2p inhibitor	[5690-03-9]

1 HMDB Compound for SIRT4 About this table

Compound	Synonyms	CAS #	PubMed Ids
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

Search CenterWatch for drugs/clinical trials and news about SIRT4 / SIR4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIRT4 gene:

NM_012240.2

Unigene Cluster for SIRT4:

Sirtuin 4

Hs.50861 [show with all ESTs]

Unigene Representative Sequence: BC034736

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000536460 ENST00000202967(uc001tyc.3) ENST00000537892

miRNA Products:		OriGene 3'-UTR Clone: SIRT4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT4
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT4:
		hsa-miR-374b* hsa-miR-424 hsa-miR-15a hsa-miR-497 hsa-miR-16 hsa-miR-195 hsa-miR-15b hsa-miR-339-5p

		SwitchGear 3'UTR luciferase reporter plasmid: SIRT4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRT4 (see all 4) OriGene shRNA RFP: SIRT4 OriGene siRNA: SIRT4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT4

Additional cDNA sequence:

AF083109.1 BC034736.1 BC109319.3 BC109320.3

3 DOTS entries:

DT.411590 DT.99963190 DT.121151837

24/27 AceView cDNA sequences (see all 27):

BM674605 BC034736 BM713962 AW025599 BF589963 NM_012240 CB139856 BM467963

AA412672 AI936687 AF083109 BF591913 BI764258 W63584 AA135913 AI192403

AA156947 AI264615 BQ708274 AA405279 AI910696 N80020 W30903 W02827

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT4 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b
SP1:
SP2:									-
SP3:
SP4:					-

ECgene alternative splicing isoforms for SIRT4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIRT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGACCACAG

About this image

SIRT4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SIRT4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRT4

SOURCE GeneReport for Unigene cluster: Hs.50861

UniProtKB/Swiss-Prot: SIR4_HUMAN, Q9Y6E7

Tissue specificity: Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in

pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus

SABiosciences Custom PCR Arrays for SIRT4

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SIRT4 gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SIRT4¹	sirtuin 4	70.65(n) 71.1(a)		416981 XM_415273.3 XP_415273.3
lizard (Anolis carolinensis)	Reptilia	SIRT4⁶ SIRT5⁶	--	63(a) 23(a)	1 ↔ 1 possible ortholog	GL343338.1(4015-5952) 4(57071927-57080042)
African clawed frog (Xenopus laevis)	Amphibia	AW643248.1²	--	74.45(n)		AW643248.1
zebrafish (Danio rerio)	Actinopterygii	zgc:103539¹	zgc:103539	64.22(n) 65.38(a)		791628 NM_001005988.1 NP_001005988.1
fruit fly (Drosophila melanogaster)	Insecta	CG3187³ Sirt4¹	CG3187-PA¹	49(a)³ 52.88(n)¹ 50(a)¹		5A10³ 31480¹ NM_132013.2¹ NP_572241.2¹
worm (Caenorhabditis elegans)	Secernentea	sir-2.2^{1 , 3}	SIR³ Protein SIR-2.2¹	49(a) (best of 2)³ 50.78(n)¹ 50.18(a)¹		X(13364196-13366297)³ 181455¹ NM_001029502.1¹ NP_001024673.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	SRT2¹	sirtuin 2	50.55(n) 45.79(a)		830782 NM_001085081.1 NP_001078550.1
rice (Oryza sativa)	Liliopsida	Os12g0179800¹	hypothetical protein	50.54(n) 46.43(a)		4351669 NM_001072842.1 NP_001066310.1
E. coli (Escherichia coli)	Gamma proteobacteria	cobB⁶	deacetylase of acs and cheY, regulates chemotaxis	27(a)	possible ortholog	Chromosome(1178854-1179582)

ENSEMBL Gene Tree for SIRT4 (if available)
TreeFam Gene Tree for SIRT4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIRT4 gene

SIRT2² SIRT3² SIRT5²

1 SIMAP similar gene for SIRT4 using alignment to 2 protein entries: SIR4_HUMAN (see all proteins):

SIRT3

SIRT4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143654868^1,2		--	120738136(+)	`TACTAA/TATGGT`	1	--	us2k¹		0	--	--	--	--
rs147180908^1,2		--	120738307(+)	`GCAGTC/TGCACA`	1	--	us2k¹		0	--	--	--	--
rs139563808^1,2		--	120738340(+)	`ATCTCC/TTGGGC`	1	--	us2k¹		0	--	--	--	--
rs55798575^1,2		--	120738492(+)	`GTGATC/TCTCCT`	1	--	us2k¹		0	--	--	--	--
rs35407225^1,2	C,F,	--	120738605(+)	`CCCTGC/ATGGCC`	1	--	us2k¹		4		NA	126
rs77482978^1,2	F,	--	120738730(+)	`CCCTGG/TGAGTG`	1	--	us2k¹		1		WA	118
rs200602670^1,2		--	120738765(+)	`TTAAT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs145500041^1,2		--	120738863(+)	`CATCAC/TTTTTG`	1	--	us2k¹		0	--	--	--	--
rs2464297^1,2	F,	--	120738885(-)	`ggcgtA/Gagcca`	1	--	us2k¹		1		WA	118
rs138194145^1,2		--	120738902(+)	`CCCAGC/TACTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIRT4 (120740119 - 120751052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIRT4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIRT4 for disorders           About GeneDecksing

OMIM gene information: 604482    OMIM disorders: --

6 diseases for SIRT4:    About MalaCards

hyperinsulinism diabetes mellitus neuropathy tuberculosis

pancreatitis mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: SIRT4 (2 documents)

Export disorders for SIRT4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SIRT4 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SIRT4)

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Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)^{1, 2, 3} Frye R.A. (1999)
Regulation of insulin secretion by SIRT4, a mitochondrial ADP- ribosyltransferase. (PubMed id 17715127)^{1, 2, 9} Ahuja N.... Verdin E. (2007)
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (PubMed id 16959573)^{1, 2} Haigis M.C.... Guarente L. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (2006)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)^{1, 2} Michishita E.... Horikawa I. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Sirtuin-4 modulates sensitivity to induction of the mi tochondrial permeability transition pore. (PubMed id 23044393)¹ Verma M....Pastorino J.G. (2013)
SIRT3 functions in the nucleus in the control of stres s-related gene expression. (PubMed id 23045395)¹ Iwahara T....Reinberg D. (2012)
The expression of Sirtuins 1 and 4 in peripheral bloo d leukocytes from patients with type 2 diabetes. (PubMed id 21556116)¹ Song R....Fu Y. (2011)
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)¹ Reiling E....Dekker J.M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23409	HGNC: 14932	AceView: SIRT4	Ensembl:ENSG00000089163	euGenes: HUgn23409
ECgene: SIRT4	H-InvDB: SIRT4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SIRT4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SIRT4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SIRT4 gene:
Search GeneIP for patents involving SIRT4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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