Aliases for SIRT3 Gene
- Sirtuin 3 2 3
- SIR2L3 3 4 6
- Regulatory Protein SIR2 Homolog 3 3 4
- SIR2-Like Protein 3 3 4
- Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae) 2
- Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3 2
- Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase 3
- Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3 3
External Ids for SIRT3 Gene
Previous GeneCards Identifiers for SIRT3 Gene
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIRT3 Gene
SIRT3 (Sirtuin 3) is a Protein Coding gene. Diseases associated with SIRT3 include uterine fibroid. Among its related pathways are Glucose / Energy Metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ binding. An important paralog of this gene is SIRT2.
UniProtKB/Swiss-Prot for SIRT3 Gene
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process through their role in resistance to cellular stress.