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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIRT3 Gene

protein-coding GIFtS: 67
GCID: GC11M000228

sirtuin 3

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)

Explore 9 diseases affiliated with
SIRT3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sirtuin 3¹ ²		NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial²
SIR2L3¹ ² ³ ⁵		NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial²
Regulatory Protein SIR2 Homolog 3² ³		Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3²
SIR2-Like Protein 3² ³		Sir2-Like 3²
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae)¹		Sirtuin Type 3²
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3¹		EC 3.5.1.-³
Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase²		HSIRT3¹

External Ids:	HGNC: 14931¹	Entrez Gene: 23410²	Ensembl: ENSG00000142082⁷	OMIM: 604481⁵	UniProtKB: Q9NTG7³

Export aliases for SIRT3 gene to outside databases

Previous GC identifers: GC11M000439 GC11M000261 GC11P000962 GC11M000206 GC11M000035 GC11M000216

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRT3:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the

sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human

sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing

and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory

proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the

sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for

this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7

Function: NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by

deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for

regulating tissue-specific ATP levels

summary for SIRT3:

Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes

closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or

nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups

from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,

sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and

mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of

transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible

antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process

through their role in resistance to cellular stress.

Gene Wiki entry for SIRT3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIRT3 gene promoter:
TBP Pbx1a AML1a HTF CREB NRF-2 deltaCREB TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIRT3 promoter sequence

Search SABiosciences Chromatin IP Primers for SIRT3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

SIRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT3 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M000228: view genomic region (about GC identifiers)

Start:	215,030 bp from pter	End:	236,931 bp from pter
Size:	21,902 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7 (See protein sequence)

Recommended Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial precursor

Size: 399 amino acids; 43573 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with NDUFA9, ACSS1, IDH2 and GDH

Subcellular location: Mitochondrion matrix

Miscellaneous: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely

in vivo

6 PDB 3D structures from and Proteopedia for SIRT3:

3GLR (3D)

3GLS (3D)

3GLT (3D)

3GLU (3D)

4FVT (3D)

4HD8 (3D)

Secondary accessions: B7Z5U6 Q9Y6E8

Alternative splicing: 2 isoforms: Q9NTG7-1 Q9NTG7-2

Explore the universe of human proteins at neXtProt for SIRT3: NX_Q9NTG7

Post-translational modifications:

Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential

for its enzymatic activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NTG7

SIRT3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001017524.1 NP_036371.1

ENSEMBL proteins:

ENSP00000372191 ENSP00000434747 ENSP00000433899 ENSP00000435464 ENSP00000432937

ENSP00000433077 ENSP00000437216 ENSP00000435505 ENSP00000437179 ENSP00000435014

ENSP00000432857 ENSP00000433132 ENSP00000436085

Human Recombinant Protein Products:

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	Novus Biologicals SIRT3 Proteins Novus Biologicals SIRT3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SIRT3
	Uscn Proteins for SIRT3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IDA	16079181
GO:0005759	mitochondrial matrix	IEA	--
GO:0016020	membrane	IEA	--

SIRT3 for ontologies About GeneDecksing

SIRT3 Antibody Products:

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	R&D Systems Antibodies for SIRT3 (Sirtuin 3/SIRT3)
	Cell Signaling Technology (CST) Antibodies for SIRT3
	OriGene Antibodies (see all 2): SIRT3 OriGene Custom Antibody Services for SIRT3
	GenScript Custom Superior Antibodies Services for SIRT3
	Novus Biologicals SIRT3 Antibodies
	Abcam antibodies for SIRT3
	Uscn Antibodies for SIRT3
	ThermoFisher Antibodies for SIRT3

Assay Products for SIRT3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SIRT3
	Enzo Life Sciences assays for SIRT3
	Uscn ELISAs and CLIAs for SIRT3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIRT3 for domains About GeneDecksing

4 InterPro domains/families:

IPR017328 NAD-dep_deAcase_SIR2_class_I

IPR003000 Sirtuin

IPR026590 Ssirtuin_cat_dom

IPR026591 Sirtuin_cat_small_dom

Graphical View of Domain Structure for InterPro Entry Q9NTG7

ProtoNet protein and cluster: Q9NTG7

1 Blocks protein family: IPB003000 Silent information regulator protein Sir2

UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7

Similarity: Belongs to the sirtuin family. Class I subfamily

Similarity: Contains 1 deacetylase sirtuin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7

Function: NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by

deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for

regulating tissue-specific ATP levels

Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

Biophysicochemical properties: Kinetic parameters: KM=600 uM for NAD;

Enzyme Number (IUBMB): EC 3.5.1.-¹

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		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT3:
		hsa-miR-505 hsa-miR-4291 hsa-miR-3150b-3p hsa-miR-922 hsa-miR-494 hsa-miR-1910 hsa-miR-384
		SwitchGear 3'UTR luciferase reporter plasmid: SIRT3 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003950	NOT NAD+ ADP-ribosyltransferase activity	TAS	17456799
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IDA	19535340
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA	--
GO:0070403	NAD+ binding	IEA	--

SIRT3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for SIRT3: Sirt3^tm1.1Fwa Sirt3^tm1.1Cxd
     10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sirt3):

adipose tissue	cardiovascular system	cellular	growth/size	homeostasis/metabolism
immune system	liver/biliary system	mortality/aging	no phenotypic analysis	normal

SIRT3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

NAD metabolism

NAD metabolism

1.00

NAD metabolism

1.00

Non-homologous end-joining

DNA damage NHEJ mechanisms of DSBs repair

0.36

DNA damage_NHEJ mechanisms of DSBs repair

0.36

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Signaling events mediated by HDAC Class I

Signaling events mediated by HDAC Class I

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for SIRT3

	NAD metabolism
	Histone modification
	DNA damage NHEJ mechanisms of DSBs repair

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT3

	p53 Signaling
	SUMO Pathway

2 Cell Signaling Technology (CST) Pathways for SIRT3

	Chromatin Regulation / Acetylation
	Glucose / Energy Metabolism

2 GeneGo (Thomson Reuters) Pathways for SIRT3

	NAD metabolism
	DNA damage NHEJ mechanisms of DSBs repair

3 BioSystems Pathways for SIRT3

	Energy Metabolism
	Signaling events mediated by HDAC Class III
	Signaling events mediated by HDAC Class I

SIRT3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SIRT3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/113 Interacting proteins for SIRT3 (Q9NTG7^{1, 2, 3} ENSP00000372191⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 113)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP5A1	P25705¹^,³, ENSP00000282050⁴	EBI-724621,EBI-351437 I2D: score=2 STRING: ENSP00000282050
ALDH2	P05091²^,³, ENSP00000261733⁴	MINT-8204646 I2D: score=2 STRING: ENSP00000261733
DNM1L	O00429³, ENSP00000266481⁴	I2D: score=3 STRING: ENSP00000266481
ATP5B	P06576³, ENSP00000262030⁴	I2D: score=2 STRING: ENSP00000262030
FOXO3	O43524³, ENSP00000339527⁴	I2D: score=2 STRING: ENSP00000339527

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006471	NOT protein ADP-ribosylation	TAS	17456799
GO:0006476	protein deacetylation	IDA	16788062
GO:0009060	aerobic respiration	IMP	--
GO:0034983	peptidyl-lysine deacetylation	IMP	--

SIRT3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SIRT3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for SIRT3 available from Tocris Bioscience About this table

Compound	Action	CAS #
Sirtinol	Selective sirtuin family deacetylase inhibitor	[410536-97-9]
Splitomicin	Sir2p inhibitor	[5690-03-9]

1 HMDB Compound for SIRT3 About this table

Compound	Synonyms	CAS #	PubMed Ids
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

1 DrugBank Compound for SIRT3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Adenosine-5-Diphosphoribose	--	--	target	--	10592235

3 Novoseek chemical compound relationships for SIRT3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nicotinamide	63.2	1	16565078 (1)
nad+	59.7	5	18722353 (1), 20132432 (1)
acetyl-coa	52.5	1	16788062 (1)

Search CenterWatch for drugs/clinical trials and news about SIRT3 / SIR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIRT3 gene (2 alternative transcripts):

NM_001017524.2 NM_012239.5

Unigene Cluster for SIRT3:

Sirtuin 3

Hs.716456 [show with all ESTs]

Unigene Representative Sequence: NM_012239

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000382743(uc001loj.4 uc001lok.4 uc010qvm.2 uc010qvn.2 uc010qvo.2 uc010qvp.2 uc010qvq.2)

ENST00000529937 ENST00000532837 ENST00000525319 ENST00000524564 ENST00000532956

ENST00000529382 ENST00000531753 ENST00000526854 ENST00000529055 ENST00000528702(uc009ybt.1)

ENST00000534381 ENST00000530067 ENST00000528469 ENST00000525776 ENST00000525237

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT3
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT3:
		hsa-miR-505 hsa-miR-4291 hsa-miR-3150b-3p hsa-miR-922 hsa-miR-494 hsa-miR-1910 hsa-miR-384
		SwitchGear 3'UTR luciferase reporter plasmid: SIRT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT3

Additional cDNA sequence:

AF083108.2 AK074992.1 AK298572.1 AK299009.1 AK299438.1 AK301558.1 AK301979.1 AK308681.1

AK316175.1 AL137276.1 BC001042.2

22 DOTS entries:

DT.95132400 DT.99932517 DT.100821814 DT.92428394 DT.120712525 DT.100776287 DT.100776280 DT.120712557

DT.100776283 DT.101959135 DT.92428397 DT.100821804 DT.120712632 DT.91658555 DT.95132405 DT.102840703

DT.120712540 DT.80101208 DT.95132402 DT.101982355 DT.120712684 DT.433861

24/192 AceView cDNA sequences (see all 192):

W95416 AI452877 BQ001375 BC001042 AA021017 BE296573 CR624703 BM671846

BQ268413 CR598105 AL543635 CR618015 AW732040 R02109 AI091200 AI492888

BU678231 AA016157 BM810987 AA340081 CR592147 BU169171 BM709066 AI445981

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT3 (see all 15) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g	^	10	^
SP1:													-												-		-		-				-		-												-		-		-
SP2:											-		-												-		-		-				-		-												-		-		-
SP3:													-		-		-								-		-		-				-		-
SP4:																																																	-
SP5:					-		-		-		-

ExUns:	11a	·	11b	·	11c	^	12a	·	12b
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SIRT3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIRT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATACATTT

About this image
See SIRT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRT3

SOURCE GeneReport for Unigene cluster: Hs.716456

UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7

Tissue specificity: Widely expressed

SABiosciences Expression via Pathway-Focused PCR Array including SIRT3:

Adipogenesis in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SIRT3 gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SIRT3¹	sirtuin (silent mating type information regulation more	72.96(n) 76.82(a)		422988 NM_001199493.1 NP_001186422.1
lizard (Anolis carolinensis)	Reptilia	SIRT3⁶ SIRT5⁶	--	65(a) 19(a)	1 ↔ 1 possible ortholog	1(77187790-77192139) 4(57071927-57080042)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4307²	Xenopus laevis transcribed sequence with weak similarity more	75.2(n)		BU913067.1
zebrafish (Danio rerio)	Actinopterygii	sirt3¹	sirtuin (silent mating type information regulation more	66.31(n) 67.97(a)		558775 NM_001080174.1 NP_001073643.1
honey bee (Apis mellifera)	Insecta	--	--	23(a)	possible ortholog	Group14.3(984618-986135)
E. coli (Escherichia coli)	Gamma proteobacteria	cobB⁶	deacetylase of acs and cheY, regulates chemotaxis	23(a)	possible ortholog	Chromosome(1178854-1179582) b1120

ENSEMBL Gene Tree for SIRT3 (if available)
TreeFam Gene Tree for SIRT3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIRT3 gene

SIRT2² SIRT4² SIRT5²

4 SIMAP similar genes for SIRT3 using alignment to 10 protein entries: SIR3_HUMAN (see all proteins):

SIRT2 SIRT1 SIR2 SIRT4

SIRT3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10081^1,2	C,F,A,H,	--	214544(-)	`AGACCG/ATTGCA`	3	--	int¹ ut3¹		22		MN NS EA NA WA CSA	4207
rs191621556^1,2		--	214638(+)	`AGCTGC/TTGCCT`	3	--	ut3¹ int¹		0	--	--	--	--
rs500840^1,2	C,F,A,H,	--	214716(-)	`GCTTGC/TTTTGT`	3	--	int¹ ut3¹		5		MN NA	312
rs183924228^1,2		--	214878(+)	`TGAGCA/GCAGGG`	3	--	ut3¹ int¹		0	--	--	--	--
rs138796024^1,2	C,	--	214902(+)	`AGACA-/TTCTCC`	3	--	int¹ ut3¹		0	--	--	--	--
rs186510149^1,2	C,	--	215012(+)	`CAACAA/GGGAAA`	3	--	int¹ ut3¹		0	--	--	--	--
rs191155373^1,2	C,	--	215045(+)	`TTGAGA/CTTTAT`	3	--	ut3¹		0	--	--	--	--
rs182247480^1,2		--	215072(+)	`AGCCAC/GAGAAA`	3	--	ut3¹		0	--	--	--	--
rs186957731^1,2		--	215340(+)	`GGAGGC/TGGAAG`	3	--	int¹ ut3¹		0	--	--	--	--
rs192912929^1,2	C,	--	215354(+)	`CAGTGA/GGCTGA`	3	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SIRT3 (215030 - 236931 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SIRT3
2 CNVs: 71209 6912
3 Indels: 24692 44860 24691
Human Gene Mutation Database (HGMD): SIRT3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIRT3 for disorders           About GeneDecksing

OMIM gene information: 604481    OMIM disorders: --

9 diseases for SIRT3:    About MalaCards

diffuse large b-cell lymphoma b-cell lymphomas uterine fibroid diabetes mellitus

breast cancer hypoxia tuberculosis hepatitis

mycobacterium tuberculosis

1 Novoseek disease relationship for SIRT3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	20159966 (1)

Genetic Association Database (GAD): SIRT3
Human Genome Epidemiology (HuGE) Navigator: SIRT3 (9 documents)

Export disorders for SIRT3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SIRT3 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with SIRT3)

Utopia: connect your pdf to the dynamic
world of online information

The human SIRT3 protein deacetylase is exclusively mitochondrial. (PubMed id 18215119)^{1, 2, 3} Cooper H.M. and Spelbrink J.N. (2008)
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)^{1, 2, 3} Frye R.A. (1999)
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. (PubMed id 12186850)^{1, 2, 9} Schwer B.... Verdin E. (2002)
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PubMed id 18680753)^{1, 2, 9} Schlicker C....Steegborn C. (2008)
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. (PubMed id 15676284)^{1, 4, 9} Bellizzi D....De Benedictis G. (2005)
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PubMed id 16788062)^{1, 2, 9} Schwer B.... Verdin E. (2006)
Crystal structures of human SIRT3 displaying substrate-induced conformational changes. (PubMed id 19535340)^{1, 2} Jin L.... Perni R.B. (2009)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)^{1, 2} Michishita E.... Horikawa I. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. (PubMed id 12374852)^{1, 2} Onyango P.... Feinberg A.P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23410	HGNC: 14931	AceView: SIRT3	Ensembl:ENSG00000142082	euGenes: HUgn23410
ECgene: SIRT3	H-InvDB: SIRT3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SIRT3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SIRT3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SIRT3 gene:
Search GeneIP for patents involving SIRT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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