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Aliases for SIRT3 Gene

Aliases for SIRT3 Gene

  • Sirtuin 3 2 3 5
  • Regulatory Protein SIR2 Homolog 3 3 4
  • SIR2-Like Protein 3 3 4
  • SIR2L3 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3 2
  • Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase 3
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3 3
  • NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial 3
  • NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial 3
  • Sirtuin Type 3 3
  • Sir2-Like 3 3
  • EC 3.5.1.- 4
  • HSIRT3 4

External Ids for SIRT3 Gene

Previous GeneCards Identifiers for SIRT3 Gene

  • GC11M000439
  • GC11M000261
  • GC11P000962
  • GC11M000206
  • GC11M000035
  • GC11M000216
  • GC11M000228
  • GC11M000241
  • GC11M000264

Summaries for SIRT3 Gene

Entrez Gene Summary for SIRT3 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT3 Gene

SIRT3 (Sirtuin 3) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class III and Organelle biogenesis and maintenance. GO annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is SIRT2.

UniProtKB/Swiss-Prot for SIRT3 Gene

  • NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.

Tocris Summary for SIRT3 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT3 Gene

Additional gene information for SIRT3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT3 Gene

Genomics for SIRT3 Gene

Regulatory Elements for SIRT3 Gene

Enhancers for SIRT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H000266 2 FANTOM5 Ensembl ENCODE dbSUPER 20.9 -33.1 -33122 6 HDGF PKNOX1 FOXA2 ARNT YY1 ZNF766 CBX5 ZNF143 ZNF207 JUNB RIC8A IFITM2 PSMD13 BET1L TMEM80 PHRF1 SNORA52 SIRT3 PGGHG ENSG00000255237
GH11H000201 0.7 Ensembl ENCODE 15.1 +34.7 34737 1 POLR2A SUPT5H SPI1 PSMD13 SIRT3 BET1L PIR60203 GC11M000210 ODF3
GH11H000215 0.7 dbSUPER 12.8 +20.2 20167 3 BCOR GATAD2A FOXA2 SAP130 L3MBTL2 SMAD5 CC2D1A CBX5 POLR2A MYNN PSMD13 BET1L SIRT3 RIC8A PIR38744
GH11H000333 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5 -98.9 -98881 4 HDAC1 HDGF RAD21 ZNF766 GATA2 EGR1 SCRT2 ZBTB11 CEBPB ZEB2 PGGHG ENSG00000255026 NLRP6 LOC105376505 ENSG00000251661 ENSG00000270972 SIRT3 B4GALNT4
GH11H000187 0.7 Ensembl ENCODE 11.4 +48.9 48931 0 PKNOX1 ZBTB33 SIRT3 PSMD13 RIC8A SCGB1C1 BET1L PIR46170
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRT3 on UCSC Golden Path with GeneCards custom track

Promoters for SIRT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035589 231 2201 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1

Genomic Location for SIRT3 Gene

Chromosome:
11
Start:
215,030 bp from pter
End:
236,931 bp from pter
Size:
21,902 bases
Orientation:
Minus strand

Genomic View for SIRT3 Gene

Genes around SIRT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT3 Gene

Proteins for SIRT3 Gene

  • Protein details for SIRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTG7-SIR3_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Protein Accession:
    Q9NTG7
    Secondary Accessions:
    • B7Z5U6
    • Q9Y6E8

    Protein attributes for SIRT3 Gene

    Size:
    399 amino acids
    Molecular mass:
    43573 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with NDUFA9, ACSS1, IDH2 and GDH.
    Miscellaneous:
    • Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo.

    Three dimensional structures from OCA and Proteopedia for SIRT3 Gene

    Alternative splice isoforms for SIRT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT3 Gene

Post-translational modifications for SIRT3 Gene

  • Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for SIRT3 (Sirtuin 3/SIRT3)
  • Cell Signaling Technology (CST) Antibodies for SIRT3 (SIRT3)

No data available for DME Specific Peptides for SIRT3 Gene

Domains & Families for SIRT3 Gene

Gene Families for SIRT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SIRT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NTG7

UniProtKB/Swiss-Prot:

SIR3_HUMAN :
  • Belongs to the sirtuin family. Class I subfamily.
Family:
  • Belongs to the sirtuin family. Class I subfamily.
genes like me logo Genes that share domains with SIRT3: view

Function for SIRT3 Gene

Molecular function for SIRT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=600 uM for NAD {ECO:0000269 PubMed:19535340};
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.

Enzyme Numbers (IUBMB) for SIRT3 Gene

Phenotypes From GWAS Catalog for SIRT3 Gene

Gene Ontology (GO) - Molecular Function for SIRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0005515 protein binding IPI 16788062
GO:0008270 zinc ion binding IDA 19535340
GO:0016787 hydrolase activity IEA --
GO:0017136 NAD-dependent histone deacetylase activity IEA --
genes like me logo Genes that share ontologies with SIRT3: view
genes like me logo Genes that share phenotypes with SIRT3: view

Animal Models for SIRT3 Gene

MGI Knock Outs for SIRT3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIRT3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT3
  • Applied Biological Materials Clones for SIRT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SIRT3 Gene

Localization for SIRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT3 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT3 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 16079181
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with SIRT3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIRT3 Gene

Pathways & Interactions for SIRT3 Gene

genes like me logo Genes that share pathways with SIRT3: view

Pathways by source for SIRT3 Gene

SIGNOR curated interactions for SIRT3 Gene

Activates:

Gene Ontology (GO) - Biological Process for SIRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 NOT protein ADP-ribosylation TAS 17456799
GO:0006476 protein deacetylation IDA 16788062
GO:0007005 mitochondrion organization TAS --
GO:0007568 aging IEA --
GO:0009060 aerobic respiration IMP 22309213
genes like me logo Genes that share ontologies with SIRT3: view

Drugs & Compounds for SIRT3 Gene

(16) Drugs for SIRT3 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 937,941
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 136
Adenosine-5-Diphosphoribose Experimental Pharma Target 0
Resveratrol Experimental, Investigational Pharma Cyclooxygenase inhibitor 123
Sirtinol Pharma SIRT inhibitor, Selective sirtuin family deacetylase inhibitor 0

(5) Additional Compounds for SIRT3 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3
SirReal 2
709002-46-0

(5) Tocris Compounds for SIRT3 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Salermide SIRT1 and SIRT2 inhibitor 1105698-15-4
SirReal 2 Selective inhibitor of SIRT2 709002-46-0
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9

(10) ApexBio Compounds for SIRT3 Gene

Compound Action Cas Number
AK-7 420831-40-9
EX-527 R-enantiomer 848193-69-1
EX-527 S-enantiomer 848193-68-0
Inauhzin SIRT1 inhibitor 309271-94-1
Resveratrol 501-36-0
Sirtinol SIRT inhibitor 410536-97-9
Splitomicin 5690-03-9
SRT2104 (GSK2245840) 1093403-33-8
Tenovin-6 SIRT inhibitor and p53 activator 1011557-82-6
Triacetyl Resveratrol Cell-permeable resveratrol prodrug 42206-94-0
genes like me logo Genes that share compounds with SIRT3: view

Drug Products

Transcripts for SIRT3 Gene

Unigene Clusters for SIRT3 Gene

Sirtuin 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT3
  • Applied Biological Materials Clones for SIRT3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - -
SP15:

ExUns: 11a · 11b · 11c ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SIRT3 Gene

GeneLoc Exon Structure for
SIRT3
ECgene alternative splicing isoforms for
SIRT3

Expression for SIRT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRT3 Gene

Protein differential expression in normal tissues from HIPED for SIRT3 Gene

This gene is overexpressed in Bone (10.9), Plasma (8.9), and Heart (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SIRT3 Gene



Protein tissue co-expression partners for SIRT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIRT3 Gene:

SIRT3

SOURCE GeneReport for Unigene cluster for SIRT3 Gene:

Hs.716456

mRNA Expression by UniProt/SwissProt for SIRT3 Gene:

Q9NTG7-SIR3_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SIRT3 Gene

  • Liver(4.5)
  • Lung(4.3)
  • Nervous system(4.2)
  • Muscle(2.8)
  • Heart(2.7)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with SIRT3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT3 Gene

Orthologs for SIRT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIRT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT3 33
  • 99.38 (n)
rat
(Rattus norvegicus)
Mammalia Sirt3 33
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia Sirt3 33 16 34
  • 83.66 (n)
cow
(Bos Taurus)
Mammalia SIRT3 33 34
  • 83.12 (n)
dog
(Canis familiaris)
Mammalia SIRT3 33 34
  • 83.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SIRT3 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIRT3 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIRT3 33 34
  • 74.29 (n)
lizard
(Anolis carolinensis)
Reptilia SIRT3 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt3 33
  • 63.13 (n)
Str.4714 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4307 33
zebrafish
(Danio rerio)
Actinopterygii sirt3 33 34
  • 67.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5085 35
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST2 34 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for SIRT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT3 Gene

ENSEMBL:
Gene Tree for SIRT3 (if available)
TreeFam:
Gene Tree for SIRT3 (if available)

Paralogs for SIRT3 Gene

Paralogs for SIRT3 Gene

genes like me logo Genes that share paralogs with SIRT3: view

Variants for SIRT3 Gene

Sequence variations from dbSNP and Humsavar for SIRT3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000072392 -- 214,932(+) CCACT(A/G)TAGTA intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000114269 -- 224,914(+) CTAAC(A/G)GGGCT intron-variant
rs1000363104 -- 220,348(+) AAAAA(A/G)AAGAA intron-variant
rs1000393950 -- 216,268(+) GAACA(C/T)GAAGA nc-transcript-variant, utr-variant-3-prime
rs1000433799 -- 221,667(+) AGATA(C/G)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRT3 Gene

Variant ID Type Subtype PubMed ID
dgv1010n100 CNV gain 25217958
dgv1011n100 CNV gain 25217958
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
dgv47e215 CNV deletion 23714750
esv1104397 CNV deletion 17803354
esv1251555 CNV deletion 17803354
esv1679398 CNV deletion 17803354
esv22231 CNV gain 19812545
esv2413108 CNV deletion 18987734
esv2674082 CNV deletion 23128226
esv2678621 CNV deletion 23128226
esv32593 CNV loss 17666407
esv3547164 CNV deletion 23714750
esv3579240 CNV loss 25503493
esv3625060 CNV gain 21293372
esv3625061 CNV gain 21293372
esv989341 CNV deletion 20482838
nsv1052484 CNV gain 25217958
nsv1124526 CNV deletion 24896259
nsv1153322 CNV deletion 26484159
nsv467630 CNV gain 19166990
nsv467631 CNV gain 19166990
nsv469921 CNV gain 18288195
nsv522596 CNV gain 19592680
nsv552762 CNV gain 21841781
nsv552765 CNV gain 21841781
nsv7632 CNV insertion 18451855

Variation tolerance for SIRT3 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.02; 75.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRT3 Gene

Human Gene Mutation Database (HGMD)
SIRT3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT3 Gene

Disorders for SIRT3 Gene

Relevant External Links for SIRT3

Genetic Association Database (GAD)
SIRT3
Human Genome Epidemiology (HuGE) Navigator
SIRT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRT3

No disorders were found for SIRT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRT3 Gene

Publications for SIRT3 Gene

  1. The human SIRT3 protein deacetylase is exclusively mitochondrial. (PMID: 18215119) Cooper HM … Spelbrink JN (The Biochemical journal 2008) 2 3 4 60
  2. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PMID: 18680753) Schlicker C … Steegborn C (Journal of molecular biology 2008) 3 4 22 60
  3. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PMID: 16788062) Schwer B … Verdin E (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 60
  4. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. (PMID: 15676284) Bellizzi D … De Benedictis G (Genomics 2005) 3 22 45 60
  5. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. (PMID: 12186850) Schwer B … Verdin E (The Journal of cell biology 2002) 3 4 22 60

Products for SIRT3 Gene

  • Addgene plasmids for SIRT3

Sources for SIRT3 Gene

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