Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SIRT3 Gene

Aliases for SIRT3 Gene

  • Sirtuin 3 2 3
  • SIR2L3 3 4 6
  • Regulatory Protein SIR2 Homolog 3 3 4
  • SIR2-Like Protein 3 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3 2
  • Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase 3
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 3 3
  • NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial 3
  • NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial 3
  • Sirtuin Type 3 3
  • Sir2-Like 3 3
  • EC 3.5.1.- 4
  • HSIRT3 4

External Ids for SIRT3 Gene

Previous GeneCards Identifiers for SIRT3 Gene

  • GC11M000439
  • GC11M000261
  • GC11P000962
  • GC11M000206
  • GC11M000035
  • GC11M000216
  • GC11M000228
  • GC11M000241
  • GC11M000264

Summaries for SIRT3 Gene

Entrez Gene Summary for SIRT3 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT3 Gene

SIRT3 (Sirtuin 3) is a Protein Coding gene. Diseases associated with SIRT3 include uterine fibroid. Among its related pathways are Glucose / Energy Metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ binding. An important paralog of this gene is SIRT2.

UniProtKB/Swiss-Prot for SIRT3 Gene

  • NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.

Tocris Summary for SIRT3 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process through their role in resistance to cellular stress.

Gene Wiki entry for SIRT3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT3 Gene

Genomics for SIRT3 Gene

Regulatory Elements for SIRT3 Gene

Genomic Location for SIRT3 Gene

Start:
215,030 bp from pter
End:
236,931 bp from pter
Size:
21,902 bases
Orientation:
Minus strand

Genomic View for SIRT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT3 Gene

Proteins for SIRT3 Gene

  • Protein details for SIRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTG7-SIR3_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Protein Accession:
    Q9NTG7
    Secondary Accessions:
    • B7Z5U6
    • Q9Y6E8

    Protein attributes for SIRT3 Gene

    Size:
    399 amino acids
    Molecular mass:
    43573 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with NDUFA9, ACSS1, IDH2 and GDH.
    Miscellaneous:
    • Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo

    Three dimensional structures from OCA and Proteopedia for SIRT3 Gene

    Alternative splice isoforms for SIRT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT3 Gene

Proteomics data for SIRT3 Gene at MOPED

Post-translational modifications for SIRT3 Gene

  • Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIRT3 Gene

Domains for SIRT3 Gene

Suggested Antigen Peptide Sequences for SIRT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NTG7

UniProtKB/Swiss-Prot:

SIR3_HUMAN :
  • Q9NTG7
Domain:
  • Contains 1 deacetylase sirtuin-type domain.
Family:
  • Belongs to the sirtuin family. Class I subfamily.
genes like me logo Genes that share domains with SIRT3: view

No data available for Gene Families for SIRT3 Gene

Function for SIRT3 Gene

Molecular function for SIRT3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=600 uM for NAD {ECO:0000269 PubMed:19535340};
UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function: NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.

Enzyme Numbers (IUBMB) for SIRT3 Gene

Gene Ontology (GO) - Molecular Function for SIRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0005515 protein binding IPI 16788062
GO:0008270 zinc ion binding IDA 19535340
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
GO:0019899 enzyme binding IEA --
genes like me logo Genes that share ontologies with SIRT3: view
genes like me logo Genes that share phenotypes with SIRT3: view

Animal Models for SIRT3 Gene

MGI Knock Outs for SIRT3:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for SIRT3 Gene

Localization for SIRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT3 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRT3 Gene COMPARTMENTS Subcellular localization image for SIRT3 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SIRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IDA 16079181
GO:0005759 mitochondrial matrix TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SIRT3: view

Pathways for SIRT3 Gene

genes like me logo Genes that share pathways with SIRT3: view

Pathways by source for SIRT3 Gene

1 Sino Biological pathway for SIRT3 Gene
2 Qiagen pathways for SIRT3 Gene
2 Cell Signaling Technology pathways for SIRT3 Gene

Gene Ontology (GO) - Biological Process for SIRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 NOT protein ADP-ribosylation TAS 17456799
GO:0006476 protein deacetylation IDA 16788062
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with SIRT3: view

Compounds for SIRT3 Gene

(6) ApexBio Compounds for SIRT3 Gene

Compound Action Cas Number
EX 527 (SEN0014196) novel, potential, and specific small-molecule inhibitor of SIRT1 [49843-98-3]
Sirtinol specific SIRT1 and SIRT2 inhibitor [410536-97-9]
sirtuin modulator sirtuin modulator. [1093403-33-8]
SRT1720 activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
Tenovin-3 Tenovin-3 [1011301-27-1]
Tenovin-6 a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

(5) Tocris Compounds for SIRT3 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor [304896-28-4]
AK 7 Selective SIRT2 inhibitor; brain penetrant [420831-40-9]
EX 527 Selective SIRT1 inhibitor [49843-98-3]
Salermide SIRT1 and SIRT2 inhibitor [1105698-15-4]
Sirtinol Selective sirtuin family deacetylase inhibitor [410536-97-9]

(1) HMDB Compounds for SIRT3 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(1) Drugbank Compounds for SIRT3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5-Diphosphoribose
target

(3) Novoseek inferred chemical compound relationships for SIRT3 Gene

Compound -log(P) Hits PubMed IDs
nicotinamide 63.2 1
nad+ 59.7 2
acetyl-coa 52.5 1
genes like me logo Genes that share compounds with SIRT3: view

Transcripts for SIRT3 Gene

Unigene Clusters for SIRT3 Gene

Sirtuin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - -
SP6: - -
SP7: - - - -
SP8: - - - - - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - -
SP15:

ExUns: 11a · 11b · 11c ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SIRT3 Gene

GeneLoc Exon Structure for
SIRT3
ECgene alternative splicing isoforms for
SIRT3

Expression for SIRT3 Gene

mRNA expression in normal human tissues for SIRT3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SIRT3 Gene

SOURCE GeneReport for Unigene cluster for SIRT3 Gene Hs.716456

mRNA Expression by UniProt/SwissProt for SIRT3 Gene

Q9NTG7-SIR3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SIRT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SIRT3 Gene

Orthologs for SIRT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIRT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT3 35
  • 99.38 (n)
  • 98.75 (a)
cow
(Bos Taurus)
Mammalia SIRT3 35
  • 83.12 (n)
  • 79.11 (a)
SIRT3 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIRT3 35
  • 83.02 (n)
  • 80.82 (a)
SIRT3 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sirt3 35
  • 83.66 (n)
  • 83.77 (a)
Sirt3 16
Sirt3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIRT3 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIRT3 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sirt3 35
  • 85.42 (n)
  • 85.94 (a)
chicken
(Gallus gallus)
Aves SIRT3 35
  • 74.29 (n)
  • 78.93 (a)
SIRT3 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIRT3 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4307 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt3 35
  • 63.13 (n)
  • 61.36 (a)
Str.4714 35
zebrafish
(Danio rerio)
Actinopterygii sirt3 35
  • 67.67 (n)
  • 70.94 (a)
sirt3 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5085 37
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST2 36
  • 34 (a)
OneToMany
HST2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for SIRT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT3 Gene

ENSEMBL:
Gene Tree for SIRT3 (if available)
TreeFam:
Gene Tree for SIRT3 (if available)

Paralogs for SIRT3 Gene

Paralogs for SIRT3 Gene

Selected SIMAP similar genes for SIRT3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with SIRT3: view

Variants for SIRT3 Gene

Sequence variations from dbSNP and Humsavar for SIRT3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10714 -- 216,290(+) CGCTC(A/G)GCCCA utr-variant-3-prime
rs475149 -- 229,093(+) AAACC(C/T)TTGCC intron-variant
rs484547 -- 226,522(-) ctgag(A/G)cagga intron-variant
rs488526 -- 229,229(+) AGGCG(A/G)ATCAC intron-variant
rs490308 -- 221,882(+) TGTAC(A/G)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRT3 Gene

Variant ID Type Subtype PubMed ID
dgv910n71 CNV Gain 21882294
esv22231 CNV Gain 19812545
nsv896436 CNV Gain 21882294
nsv896437 CNV Loss 21882294
dgv911n71 CNV Gain 21882294
nsv467630 CNV Gain 19166990
nsv522596 CNV Gain 19592680
nsv467631 CNV Gain 19166990
nsv896439 CNV Loss 21882294
nsv896440 CNV Gain 21882294
nsv896441 CNV Loss 21882294
esv32593 CNV Loss 17666407
dgv912n71 CNV Gain 21882294
nsv469921 CNV Gain 18288195
esv2674082 CNV Deletion 23128226
esv1679398 CNV Deletion 17803354
esv2413108 CNV Deletion 18987734
esv2678621 CNV Deletion 23128226
esv1104397 CNV Deletion 17803354
esv989341 CNV Deletion 20482838
esv1251555 CNV Deletion 17803354
nsv7632 CNV Insertion 18451855
nsv896445 CNV Loss 21882294
nsv896447 CNV Loss 21882294

Relevant External Links for SIRT3 Gene

HapMap Linkage Disequilibrium report
SIRT3
Human Gene Mutation Database (HGMD)
SIRT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT3 Gene

Disorders for SIRT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SIRT3 Gene including...

Search for SIRT3 Gene in MalaCards »

(1) Novoseek inferred disease relationships for SIRT3 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1

Relevant External Links for SIRT3

Genetic Association Database (GAD)
SIRT3
Human Genome Epidemiology (HuGE) Navigator
SIRT3
genes like me logo Genes that share disorders with SIRT3: view

No data available for UniProtKB/Swiss-Prot for SIRT3 Gene

Publications for SIRT3 Gene

  1. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. (PMID: 12186850) Schwer B. … Verdin E. (J. Cell Biol. 2002) 3 4 23
  2. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PMID: 16788062) Schwer B. … Verdin E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  3. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PMID: 18680753) Schlicker C. … Steegborn C. (J. Mol. Biol. 2008) 3 4 23
  4. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. (PMID: 15676284) Bellizzi D. … De Benedictis G. (Genomics 2005) 3 23 48
  5. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PMID: 10381378) Frye R.A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4

Products for SIRT3 Gene

  • Addgene plasmids for SIRT3

Sources for SIRT3 Gene

Back to Top

Content