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SIRT3 Gene

protein-coding   GIFtS: 64
GCID: GC11M000264

Sirtuin 3

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)
  See SIRT3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sirtuin 31 2     NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial2
SIR2L32 3 5     NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial2
Regulatory Protein SIR2 Homolog 32 3     Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 32
SIR2-Like Protein 32 3     Sir2-Like 32
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S.
Cerevisiae)1
     Sirtuin Type 32
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae,
Homolog) 31
     EC 3.5.1.-3
Mitochondrial Nicotinamide Adenine Dinucleotide-Dependent Deacetylase2     hSIRT33

External Ids:    HGNC: 149311   Entrez Gene: 234102   Ensembl: ENSG000001420827   OMIM: 6044815   UniProtKB: Q9NTG73   

Export aliases for SIRT3 gene to outside databases

Previous GC identifers: GC11M000439 GC11M000261 GC11P000962 GC11M000206 GC11M000035 GC11M000216 GC11M000228 GC11M000241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIRT3 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different
proteins have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIRT3 Gene:
SIRT3 (sirtuin 3) is a protein-coding gene. Diseases associated with SIRT3 include uterine fibroid. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD+ binding. An important paralog of this gene is SIRT2.

UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7
Function: NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by
deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP
synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating
tissue-specific ATP levels

summary for SIRT3 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SIRT3 gene promoter:
         TBP   Pbx1a   AML1a   HTF   CREB   NRF-2   deltaCREB   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT3 promoter sequence
   Search Chromatin IP Primers for SIRT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

SIRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000264:  view genomic region     (about GC identifiers)

Start:
215,030 bp from pter      End:
236,931 bp from pter
Size:
21,902 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial precursor  
Size: 399 amino acids; 43573 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with NDUFA9, ACSS1, IDH2 and GDH
Miscellaneous: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is
unlikely in vivo
Selected PDB 3D structures from and Proteopedia for SIRT3 (see all 20):
3GLR (3D)        3GLS (3D)        3GLT (3D)        3GLU (3D)        4BN4 (3D)        4BN5 (3D)    
Secondary accessions: B7Z5U6 Q9Y6E8
Alternative splicing: 2 isoforms:  Q9NTG7-1   Q9NTG7-2   

Explore the universe of human proteins at neXtProt for SIRT3: NX_Q9NTG7

Explore proteomics data for SIRT3 at MOPED

Post-translational modifications: 

  • Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably
    essential for its enzymatic activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SIRT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017524.1  NP_036371.1  

    ENSEMBL proteins: 
     ENSP00000372191   ENSP00000434747   ENSP00000433899   ENSP00000435464   ENSP00000432937  
     ENSP00000433077   ENSP00000437216   ENSP00000435505   ENSP00000437179   ENSP00000435014  
     ENSP00000432857   ENSP00000433132   ENSP00000436085  
    Reactome Protein details: Q9NTG7

    SIRT3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SIRT3
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    Novus Biologicals SIRT3 Proteins
    Novus Biologicals SIRT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SIRT3
    Cloud-Clone Corp. Proteins for SIRT3

     
    Search eBioscience for Proteins for SIRT3 

     
    antibodies-online proteins for SIRT3 (17 products) 

     
    antibodies-online peptides for SIRT3

    SIRT3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SIRT3
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    antibodies-online antibodies for SIRT3 (107 products) 

    SIRT3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SIRT3
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    antibodies-online kits for SIRT3 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR026591 Sirtuin_cat_small_dom
     IPR017328 Sirtuin_class_I
     IPR003000 Sirtuin
     IPR026590 Ssirtuin_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NTG7

    ProtoNet protein and cluster: Q9NTG7

    1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7
    Similarity: Belongs to the sirtuin family. Class I subfamily
    Similarity: Contains 1 deacetylase sirtuin-type domain


    Find genes that share domains with SIRT3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIR3_HUMAN, Q9NTG7
    Function: NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by
    deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP
    synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating
    tissue-specific ATP levels
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein
    Biophysicochemical properties: Kinetic parameters: KM=600 uM for NAD;

         Enzyme Number (IUBMB): EC 3.5.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NOT NAD+ ADP-ribosyltransferase activity TAS17456799
    GO:0005515protein binding IPI16788062
    GO:0008270zinc ion binding IDA19535340
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
    GO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific) IEA--
         
    Find genes that share ontologies with SIRT3           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sirt3):
     adipose tissue  cardiovascular system  cellular  growth/size/body  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  no phenotypic analysis  normal 

    Find genes that share phenotypes with SIRT3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SIRT3: Sirt3tm1.1Fwa Sirt3tm1.1Cxd

       genOway: Develop your customized and physiologically relevant rodent model for SIRT3

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    7 qRT-PCR Assays for microRNAs that regulate SIRT3:
    hsa-miR-505 hsa-miR-4291 hsa-miR-3150b-3p hsa-miR-922 hsa-miR-494 hsa-miR-1910 hsa-miR-384
    SwitchGear 3'UTR luciferase reporter plasmidSIRT3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SIRT3
    Predesigned siRNA for gene silencing in human, mouse, rat SIRT3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SIRT3 (NM_012239)
    Sino Biological Human cDNA Clone for SIRT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT3
    Addgene plasmids for SIRT3 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIRT3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIR3_HUMAN, Q9NTG7: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus2
    cytosol1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA16079181
    GO:0005759mitochondrial matrix IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with SIRT3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIRT3 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    3Non-homologous end-joining
    DNA damage NHEJ mechanisms of DSBs repair0.37
    4Packaging Of Telomere Ends
    Histone modification0.31
    54-1BB Pathway
    SUMO Pathway0.30


    Find genes that share SuperPaths with SIRT3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIRT3
        p53 Signaling
    SUMO Pathway

    2 Cell Signaling Technology (CST) Pathways for SIRT3
        Chromatin Regulation / Acetylation
    Glucose / Energy Metabolism

    2 GeneGo (Thomson Reuters) Pathways for SIRT3
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    3 BioSystems Pathways for SIRT3
        Energy Metabolism
    Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class I

    1 Sino Biological Pathway for SIRT3
        p53 Pathway

    1 Reactome Pathway for SIRT3
        Transcriptional activation of mitochondrial biogenesis


        Pathway & Disease-focused RT2 Profiler PCR Array including SIRT3: 
              Adipogenesis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SIRT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIRT3 (Q9NTG71, 2, 3 ENSP000003721914) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5A1P257051, 3, ENSP000002820504EBI-724621,EBI-351437 I2D: score=2 STRING: ENSP00000282050
    ENSG00000234258P349313, ENSP000003964864I2D: score=2 STRING: ENSP00000396486
    ENSG00000206383P349313I2D: score=2 
    ENSG00000236251P349313I2D: score=2 
    HSPA1LP349313I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006471NOT protein ADP-ribosylation TAS17456799
    GO:0006476protein deacetylation IDA16788062
    GO:0009060aerobic respiration IMP--
    GO:0034983peptidyl-lysine deacetylation IMP--

    Find genes that share ontologies with SIRT3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    6 ApexBio Compounds for SIRT3     About this table
    CompoundAction CAS #
    EX 527 (SEN0014196)novel, potential, and specific small-molecule inhibitor of SIRT1[49843-98-3]
    Sirtinolspecific SIRT1 and SIRT2 inhibitor[410536-97-9]
    sirtuin modulatorsirtuin modulator[1093403-33-8]
    SRT1720activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
    Tenovin-3Tenovin-3 [1011301-27-1]
    Tenovin-6a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

    Compounds for SIRT3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
    SplitomicinSir2p inhibitor[5690-03-9]
    AGK 2Selective SIRT2 inhibitor[304896-28-4]

    1 HMDB Compound for SIRT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    1 DrugBank Compound for SIRT3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5-Diphosphoribose-- --target--10592235

    3 Novoseek inferred chemical compound relationships for SIRT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nicotinamide 63.2 1 16565078 (1)
    nad+ 59.7 5 18722353 (1), 20132432 (1)
    acetyl-coa 52.5 1 16788062 (1)



    Find genes that share compounds with SIRT3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SIRT3 gene (2 alternative transcripts): 
    NM_001017524.2  NM_012239.5  

    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382743(uc001loj.4 uc001lok.4 uc010qvm.2 uc010qvn.2 uc010qvo.2 uc010qvp.2 uc010qvq.2)
    ENST00000529937 ENST00000532837 ENST00000525319 ENST00000524564 ENST00000532956
    ENST00000529382 ENST00000531753 ENST00000526854 ENST00000529055 ENST00000528702(uc009ybt.1)
    ENST00000534381 ENST00000530067 ENST00000528469 ENST00000525776 ENST00000525237

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    7 qRT-PCR Assays for microRNAs that regulate SIRT3:
    hsa-miR-505 hsa-miR-4291 hsa-miR-3150b-3p hsa-miR-922 hsa-miR-494 hsa-miR-1910 hsa-miR-384
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    Selected AceView cDNA sequences (see all 192):

    BQ268413 BE296573 BU856008 BQ001375 BM810987 AL543635 AI445981 AL137276 
    BU678231 W95416 BM912425 AA021017 AI342359 AA016157 BI755839 CR624703 
    BM709066 AI091200 BI761668 CB305647 BC001042 AA340081 BM671846 AL578986 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIRT3 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^
    SP1:                                      -                                   -     -     -           -     -                                   -     -     -   
    SP2:                                -     -                                   -     -     -           -     -                                   -     -     -   
    SP3:                                      -     -     -                       -     -     -           -     -                                                   
    SP4:                                                                                                                                                  -         
    SP5:              -     -     -     -                                                                                                                           

    ExUns: 11a · 11b · 11c ^ 12a · 12b
    SP1:              -               
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for SIRT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SIRT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATACATTT
    SIRT3 Expression
    About this image

    SIRT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIRT3 Protein Expression

    UniProtKB/Swiss-Prot: SIR3_HUMAN, Q9NTG7
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including SIRT3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SIRT3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirt31 , 5 sirtuin 3 (silent mating type information regulation more5
    sirtuin 31
    83.66(n)1
    83.77(a)1
      7 (86.07 cM)5
    643841  NM_001177804.11  NP_001171275.11 
     1408636705 
    chicken
    (Gallus gallus)
    Aves SIRT31 sirtuin (silent mating type information regulation more 74.29(n)
    78.93(a)
      422988  NM_001199493.1  NP_001186422.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIRT36
    sirtuin 3
    65(a)
    1 ↔ 1
    1(77187790-77194544)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.43072 Xenopus laevis transcribed sequence with weak similarity more 75.2(n)    BU913067.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sirt31 sirtuin (silent mating type information regulation more 67.67(n)
    70.94(a)
      558775  NM_001080174.1  NP_001073643.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HST2(YPL015C)4 Cytoplasmic member of the silencing information regulator more   --   16(526883-525810) 856092  NP_015310.1 


    ENSEMBL Gene Tree for SIRT3 (if available)
    TreeFam Gene Tree for SIRT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIRT3 gene
    SIRT22  
    3 SIMAP similar genes for SIRT3 using alignment to 10 protein entries:     SIR3_HUMAN (see all proteins):
    SIRT2    SIRT1    SIR2

    Find genes that share paralogs with SIRT3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIRT3 (see all 730)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs171558301,2
    C,F--215626(+) CACGCA/GGGTAA 2 -- ut31 ese36Minor allele frequency- G:0.04NA WA CSA 262
    rs1397114271,2
    C--215804(+) GGTGGC/GCAGGA 2 -- ut310--------
    rs122264021,2
    C--215904(+) GGGGCG/ATAGTG 2 -- ut31 ese34Minor allele frequency- A:0.10WA NA EA 360
    rs744620311,2
    C,F--215908(+) CGTAGT/GGTGGG 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs1443710901,2
    C--215975(+) GGAGAA/GGCTGA 2 -- ut310--------
    rs1885157991,2
    --216031(+) GGGCCA/GTCTCC 2 -- ut310--------
    rs1929428811,2
    --216051(+) AGGGAC/TAAATG 2 -- ut310--------
    rs122266971,2
    C,F,H--216056(+) CAAATG/ACCTTC 2 -- ut3115Minor allele frequency- A:0.10NS EA NA WA 1388
    rs1844166731,2
    --216095(+) CGCCAC/TGTATC 2 -- ut310--------
    rs1891978041,2
    --216169(+) CATGCC/TGGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SIRT3 (215030 - 236931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SIRT3 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2413108CNV Deletion18987734
    esv2678621CNV Deletion23128226
    esv1679398CNV Deletion17803354
    esv1251555CNV Deletion17803354
    esv1104397CNV Deletion17803354
    esv2674082CNV Deletion23128226
    esv989341CNV Deletion20482838
    nsv7632CNV Insertion18451855
    nsv896437CNV Loss21882294
    esv32593CNV Loss17666407

    Human Gene Mutation Database (HGMD): SIRT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIRT3
    DNA2.0 Custom Variant and Variant Library Synthesis for SIRT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604481    OMIM disorders: --

    1 disease for SIRT3:    
    About MalaCards
    uterine fibroid


    Find genes that share disorders with SIRT3           About GenesLikeMe

    1 Novoseek inferred disease relationship for SIRT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 20159966 (1)

    Genetic Association Database (GAD): SIRT3
    Human Genome Epidemiology (HuGE) Navigator: SIRT3 (9 documents)

    Export disorders for SIRT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIRT3 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with SIRT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human SIRT3 protein deacetylase is exclusively mitochondrial. (PubMed id 18215119)1, 2, 3 Cooper H.M. and Spelbrink J.N. (Biochem. J. 2008)
    2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)1, 2, 3 Frye R.A. (Biochem. Biophys. Res. Commun. 1999)
    3. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. (PubMed id 12186850)1, 2, 9 Schwer B.... Verdin E. (J. Cell Biol. 2002)
    4. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PubMed id 18680753)1, 2, 9 Schlicker C....Steegborn C. (J. Mol. Biol. 2008)
    5. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. (PubMed id 15676284)1, 4, 9 Bellizzi D....De Benedictis G. (Genomics 2005)
    6. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PubMed id 16788062)1, 2, 9 Schwer B.... Verdin E. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    7. SIRT3 regulates long-chain acyl-coA dehydrogenase by deacetylating conserved lysines near the active site. (PubMed id 24121500)1, 2 Bharathi S.S.... Goetzman E.S. (J. Biol. Chem. 2013)
    8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    9. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    10. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23410 HGNC: 14931 AceView: SIRT3 Ensembl:ENSG00000142082 euGenes: HUgn23410
    ECgene: SIRT3 H-InvDB: SIRT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SIRT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SIRT3 gene:
    Search GeneIP for patents involving SIRT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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