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SIRT2 Gene

protein-coding   GIFtS: 66
GCID: GC19M039369

Sirtuin 2

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)
(Previous symbol: SIR2L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sirtuin 21 2     NAD-Dependent Deacetylase Sirtuin-22
SIR2L1 2 3 5     NAD-Dependent Protein Deacetylase Sirtuin-22
SIR2L22 3 5     Silent Information Regulator 22
Regulatory Protein SIR2 Homolog 22 3     Sir2-Related Protein Type 22
SIR2-Like Protein 22 3     Sirtuin Type 22
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 2 (S.
Cerevisiae)1
     sirtuin-22
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae,
Homolog) 21
     EC 3.5.1.-3
SIR22     

External Ids:    HGNC: 108861   Entrez Gene: 229332   Ensembl: ENSG000000689037   OMIM: 6044805   UniProtKB: Q8IXJ63   
ORGUL members:         

Export aliases for SIRT2 gene to outside databases

Previous GC identifers: GC19M039981 GC19M039760 GC19M044045 GC19M044061 GC19M035815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SIRT2 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of
this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for SIRT2 Gene:
SIRT2 (sirtuin 2) is a protein-coding gene. Diseases associated with SIRT2 include lip cancer, and obesity, association with. GO annotations related to this gene include ubiquitin binding and transcription factor binding. An important paralog of this gene is SIRT3.

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6
Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone
proteins such as ACLY, PCK1 and RELA. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic
exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing
proteasomal degradation. Deacetylates 'Lys-310' of RELA

summary for SIRT2 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SIRT2 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT2 promoter sequence
   Search Chromatin IP Primers for SIRT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SIRT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

SIRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039369:  view genomic region     (about GC identifiers)

Start:
39,369,195 bp from pter      End:
39,390,502 bp from pter
Size:
21,308 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-2  
Size: 389 amino acids; 43182 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the
cytoskeleton
Developmental stage: Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome
Miscellaneous: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is
unlikely in vivo
Sequence caution: Sequence=AAD45971.1; Type=Erroneous initiation; Sequence=AAF67015.1; Type=Frameshift;
Positions=Several;
3 PDB 3D structures from and Proteopedia for SIRT2:
1J8F (3D)        3ZGO (3D)        3ZGV (3D)    
Secondary accessions: A8K3V1 B2RB45 O95889 Q924Y7 Q9P0G8 Q9UNT0 Q9Y6E9
Alternative splicing: 4 isoforms:  Q8IXJ6-1   Q8IXJ6-2   Q8IXJ6-3   Q8IXJ6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRT2: NX_Q8IXJ6

Explore proteomics data for SIRT2 at MOPED

Post-translational modifications: 

  • Phosphorylated at the G2/M transition of the cell cycle1
  • Ubiquitination2 at Lys55
  • Modification sites at PhosphoSitePlus

  • See SIRT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180215.1  NP_036369.2  NP_085096.1  

    ENSEMBL proteins: 
     ENSP00000249396   ENSP00000375931   ENSP00000404309   ENSP00000400338   ENSP00000411393  
     ENSP00000385146   ENSP00000401203   ENSP00000407272   ENSP00000409690   ENSP00000397022  
     ENSP00000408023   ENSP00000351809  

    SIRT2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SIRT2
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    Novus Biologicals SIRT2 Proteins
    Novus Biologicals SIRT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SIRT2
    Cloud-Clone Corp. Proteins for SIRT2

    SIRT2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SIRT2
    R&D Systems Antibodies for SIRT2 (Sirtuin 2/SIRT2)
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    LSBio Antibodies in human, mouse, rat for SIRT2

    SIRT2 Assay Products:

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    Enzo Life Sciences assays for SIRT2
    Cloud-Clone Corp. ELISAs for SIRT2
    Cloud-Clone Corp. CLIAs for SIRT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR017328 Sirtuin_class_I
     IPR003000 Sirtuin
     IPR026590 Ssirtuin_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8IXJ6

    ProtoNet protein and cluster: Q8IXJ6

    1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6
    Similarity: Belongs to the sirtuin family. Class I subfamily
    Similarity: Contains 1 deacetylase sirtuin-type domain


    SIRT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIR2_HUMAN, Q8IXJ6
    Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone
    proteins such as ACLY, PCK1 and RELA. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic
    exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing
    proteasomal degradation. Deacetylates 'Lys-310' of RELA
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein
    Enzyme regulation: Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide

         Enzyme Number (IUBMB): EC 3.5.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NOT NAD+ ADP-ribosyltransferase activity TAS17456799
    GO:0005515protein binding IPI12697818
    GO:0008134transcription factor binding IPI12887892
    GO:0008270zinc ion binding IDA11427894
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
         
    SIRT2 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Sirt2):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     nervous system  normal  other  tumorigenesis 

    SIRT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SIRT2: Sirt2tm1Gdon Sirt2tm1.2Jmi Sirt2tm1.1Cxd Sirt2tm1.1Fwa

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SIRT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SIRT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIRT2

    miRNA
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    miRTarBase miRNAs that target SIRT2:
    hsa-mir-7-5p (MIRT025871)

    Block miRNA regulation of human, mouse, rat SIRT2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate SIRT2:
    hsa-miR-4303 hsa-miR-4283 hsa-miR-1303 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSIRT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SIRT2
    Predesigned siRNA for gene silencing in human, mouse, rat SIRT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SIRT2

    Clone
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    OriGene clones in human, mouse for SIRT2 (see all 17)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SIRT2 (NM_030593)
    Sino Biological Human cDNA Clone for SIRT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SIRT2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SIR2_HUMAN, Q8IXJ6: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005677chromatin silencing complex NAS12697818
    GO:0005737cytoplasm IDA12697818
    GO:0005874microtubule IDA12620231

    SIRT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SIRT2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    2Nicotinate and nicotinamide metabolism
    NAD metabolism0.43
    3Non-homologous end-joining
    DNA damage NHEJ mechanisms of DSBs repair0.37
    4Packaging Of Telomere Ends
    Histone modification0.31
    54-1BB Pathway
    SUMO Pathway0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SIRT2
        p53 Signaling
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for SIRT2
        Chromatin Regulation / Acetylation

    2 GeneGo (Thomson Reuters) Pathways for SIRT2
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    2 BioSystems Pathways for SIRT2
        Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class I

    1 Sino Biological Pathway for SIRT2
        p53 Pathway



    SIRT2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SIRT2 (see all 6): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SIRT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SIRT2 (Q8IXJ61, 2, 3 ENSP000002493964) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000183chromatin silencing at rDNA NAS11427894
    GO:0006342chromatin silencing NAS12697818
    GO:0006348chromatin silencing at telomere NAS11427894
    GO:0006471NOT protein ADP-ribosylation TAS17456799
    GO:0006476protein deacetylation IDA17172643

    SIRT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for SIRT2
    6 ApexBio Compounds for SIRT2     About this table
    CompoundAction CAS #
    EX 527 (SEN0014196)novel, potential, and specific small-molecule inhibitor of SIRT1[49843-98-3]
    Sirtinolspecific SIRT1 and SIRT2 inhibitor[410536-97-9]
    sirtuin modulatorsirtuin modulator[1093403-33-8]
    SRT1720activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
    Tenovin-3Tenovin-3 [1011301-27-1]
    Tenovin-6a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

    Compounds for SIRT2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
    SplitomicinSir2p inhibitor[5690-03-9]
    AGK 2Selective SIRT2 inhibitor[304896-28-4]

    1 HMDB Compound for SIRT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    1 Novoseek inferred chemical compound relationship for SIRT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nad+ 67.4 9 19060927 (1), 16211212 (1), 17628866 (1)



    SIRT2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SIRT2 gene (3 alternative transcripts): 
    NM_001193286.1  NM_012237.3  NM_030593.2  

    Unigene Cluster for SIRT2:

    Sirtuin 2
    Hs.466693  [show with all ESTs]
    Unigene Representative Sequence: NM_012237
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479290 ENST00000462654(uc010egi.2 uc002ojs.2) ENST00000249396(uc002ojt.2 uc002ojv.2)
    ENST00000392081(uc002oju.2 uc010egh.2) ENST00000496069 ENST00000414941
    ENST00000420440 ENST00000443898 ENST00000407552 ENST00000381766 ENST00000491960
    ENST00000476771 ENST00000451193 ENST00000423526 ENST00000437828 ENST00000447739
    ENST00000481381 ENST00000358931
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      QuantiFast Probe-based Assays in human, mouse, rat SIRT2

    Additional mRNA sequence: 

    AB009274.1 AF083107.2 AF095714.1 AF131800.1 AF160214.1 AK025876.1 AK054642.1 AK225824.1 
    AK290716.1 AK314492.1 AY030277.1 BC003012.1 BC003547.1 NR_034146.1 

    Selected DOTS entries (see all 27):

    DT.100883254  DT.447660  DT.100883257  DT.100883265  DT.100883250  DT.86854504  DT.99958966  DT.429673 
    DT.95281347  DT.97855683  DT.100883271  DT.100883270  DT.121500146  DT.75198292  DT.100030658  DT.100883272 
    DT.102830215  DT.91841242  DT.95105807  DT.98131735  DT.99936055  DT.100883252  DT.121500101  DT.91779085 

    Selected AceView cDNA sequences (see all 544):

    CA454453 BU196170 AA535900 BX439457 BG386360 BQ068338 BQ058696 BI523850 
    BM544569 BQ068262 BM771970 AL583280 BU507144 CD742627 AU279964 AY030277 
    CD558177 BI517372 CR623364 AA339049 CB144280 NM_030593 BU182713 BM837612 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SIRT2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j · 1k ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ·
    SP1:                                                                    -           -     -     -           -           -                             -     -   
    SP2:                                                                    -           -     -     -           -           -                             -     -   
    SP3:                                                                    -     -     -     -     -           -           -                             -     -   
    SP4:                                                                                                                    -                             -     -   
    SP5:                                                                                                        -           -                             -     -   

    ExUns: 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
    SP1:  -                                                           -                     
    SP2:  -                                                           -                     
    SP3:  -                                                           -                     
    SP4:  -                                                           -                     
    SP5:  -                                         -     -     -     -     -               


    ECgene alternative splicing isoforms for SIRT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SIRT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGATGGGC
    SIRT2 Expression
    About this image


    SIRT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
    SIRT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SIRT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466693

    UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6
    Tissue specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly
    expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor
    gene in human gliomas possibly through the regulation of microtubule network

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SIRT2 (see all 6): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SIRT2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirt21 , 5 sirtuin 2 (silent mating type information regulation more5
    sirtuin 21
    85.86(n)1
    87.66(a)1
      7 (16.92 cM)5
    643831  NM_022432.41  NP_071877.31 
     287667355 
    chicken
    (Gallus gallus)
    Aves SIRT21 sirtuin 2 73.29(n)
    74.56(a)
      548628  NM_001017414.1  NP_001017414.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIRT26
    sirtuin 2
    63(a)
    1 ↔ 1
    GL343885.1(18663-30561)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF522612.12   -- 73.4(n)    CF522612.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb57d052 wufb57d05 77.05(n)   322309  BC045510.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50853
    Sirt21
    NAD-dependent histone deacetylase3
    Sirt21
    49(a)3
    55.85(n)1
    51.46(a)1
      92E33
    424141  NM_142623.31  NP_650880.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HST21 HST2 49.88(n)
    47.81(a)
      856092   NP_015310.1 


    ENSEMBL Gene Tree for SIRT2 (if available)
    TreeFam Gene Tree for SIRT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SIRT2 gene
    SIRT32  
    3 SIMAP similar genes for SIRT2 using alignment to 11 protein entries:     SIR2_HUMAN (see all proteins):
    SIR2    SIRT3    SIRT1

    SIRT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SIRT2 (see all 518)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72497931,2
    C--39371013(+) AGACCC/TAGAGC 4 -- int14Minor allele frequency- T:0.22WA NA EA 360
    rs72496751,2
    C,F,A--39371014(+) GACCCA/GGAGCG 4 -- int15Minor allele frequency- G:0.34WA CSA NA EA 362
    rs1860541801,2
    --39371039(+) CCCCCC/GGCACT 4 -- int10--------
    rs169728621,2
    C,F--39371122(+) CTGGTT/GTGAGT 4 -- int17Minor allele frequency- G:0.09NA CSA WA 377
    rs1898387161,2
    C--39371289(+) GGGGAA/GCCTGT 4 -- int10--------
    rs2014311981,2
    --39371353(+) TGAGCA/GGGCGA 6 P L mis1 int10--------
    rs2007775381,2
    C--39371374(+) GGGGTA/GCCCTG 6 A V mis1 int10--------
    rs1120098201,2
    C,F--39371446(+) AGCCAC/TAGCCC 4 -- int12Minor allele frequency- T:0.01CSA EU 1024
    rs1388054951,2
    C--39371459(+) AACCTA/GCTTGC 4 -- spd1 int11Minor allele frequency- G:0.00NA 4468
    rs2007294061,2
    --39371499(+) AAGGAA/GGTACC 7 T syn10--------

    HapMap Linkage Disequilibrium report for SIRT2 (39369195 - 39390502 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SIRT2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SIRT2
    DNA2.0 Custom Variant and Variant Library Synthesis for SIRT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604480    OMIM disorders: --

    Selected diseases for SIRT2 (see all 21):    
    About MalaCards
    lip cancer    obesity, association with    multiple system atrophy    temporal lobe epilepsy
    mood disorder    huntington's disease    obesity    parkinson's disease
    multiple sclerosis    diabetes mellitus    tuberculosis    melanoma
    prostate cancer    squamous cell carcinoma    prostatitis    malaria
    hepatocellular carcinoma    cerebritis    hepatitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for SIRT2:
    Diabetes mellitus

    SIRT2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for SIRT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.16 5 19060927 (1), 19559674 (1), 10393250 (1)
    tumors 0 3 16211212 (1), 12963026 (1), 19559674 (1)

    Human Genome Epidemiology (HuGE) Navigator: SIRT2 (1 document)

    Export disorders for SIRT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SIRT2 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with SIRT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. (PubMed id 10393250)1, 2, 3, 9 Afshar G. and Murnane J.P. (Gene 1999)
    2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)1, 2, 3 Frye R.A. (Biochem. Biophys. Res. Commun. 1999)
    3. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. (PubMed id 12697818)1, 2, 9 Dryden S.C.... Tainsky M.A. (Mol. Cell. Biol. 2003)
    4. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PubMed id 12620231)1, 2, 9 North B.J.... Verdin E. (Mol. Cell 2003)
    5. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. (PubMed id 12963026)1, 2, 9 Hiratsuka M....Oshimura M. (Biochem. Biophys. Res. Commun. 2003)
    6. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1, 2 Jiang W.... Zhao S. (Mol. Cell 2011)
    7. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2 Michishita E.... Horikawa I. (Mol. Biol. Cell 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Conserved enzymatic production and biological effect of O-acetyl-ADP- ribose by silent information regulator 2-like NAD+-dependent deacetylases. (PubMed id 11812793)1, 2 Borra M.T.... Denu J.M. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22933 HGNC: 10886 AceView: SIRT2 Ensembl:ENSG00000068903 euGenes: HUgn22933
    ECgene: SIRT2 H-InvDB: SIRT2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SIRT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SIRT2 gene:
    Search GeneIP for patents involving SIRT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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