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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIRT2 Gene

protein-coding   GIFtS: 65
GCID: GC19M039369

Sirtuin 2

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)
(Previous symbol: SIR2L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sirtuin 21 2     SIR22
SIR2L1 2 3 5     NAD-Dependent Deacetylase Sirtuin-22
SIR2L22 3 5     NAD-Dependent Protein Deacetylase Sirtuin-22
Regulatory Protein SIR2 Homolog 22 3     Silent Information Regulator 22
SIR2-Like Protein 22 3     Sir2-Related Protein Type 22
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 2 (S.
Cerevisiae)1
     Sirtuin Type 22
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae,
Homolog) 21
     EC 3.5.1.-3

External Ids:    HGNC: 108861   Entrez Gene: 229332   Ensembl: ENSG000000689037   OMIM: 6044805   UniProtKB: Q8IXJ63   
ORGUL members:         
NONCODE14:n409745      

Export aliases for SIRT2 gene to outside databases

Previous GC identifers: GC19M039981 GC19M039760 GC19M044045 GC19M044061 GC19M035815


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRT2 Gene:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the
sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human
sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene
silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as
intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is
included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of
this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for SIRT2 Gene: 
SIRT2 (sirtuin 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SIRT2 include lip cancer, and multiple system atrophy, and among its related super-pathways are p53 Signaling and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include ubiquitin binding and transcription factor binding. An important paralog of this gene is SIRT4.

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6
Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone
proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle,
probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation.
Deacetylates 'Lys-310' of RELA

summary for SIRT2 Gene:
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes
closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or
nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups
from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,
sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and
mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of
transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible
antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process
through their role in resistance to cellular stress.

Gene Wiki entry for SIRT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIRT2 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SIRT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

SIRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039369:  view genomic region     (about GC identifiers)

Start:
39,369,195 bp from pter      End:
39,390,502 bp from pter
Size:
21,308 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6 (See protein sequence)
Recommended Name: NAD-dependent protein deacetylase sirtuin-2  
Size: 389 amino acids; 43182 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the
cytoskeleton
Subcellular location: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules
Developmental stage: Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome
Miscellaneous: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is
unlikely in vivo
Sequence caution: Sequence=AAD45971.1; Type=Erroneous initiation; Sequence=AAF67015.1; Type=Frameshift;
Positions=Several;
3 PDB 3D structures from and Proteopedia for SIRT2:
1J8F (3D)        3ZGO (3D)        3ZGV (3D)    
Secondary accessions: A8K3V1 B2RB45 O95889 Q924Y7 Q9P0G8 Q9UNT0 Q9Y6E9
Alternative splicing: 4 isoforms:  Q8IXJ6-1   Q8IXJ6-2   Q8IXJ6-3   Q8IXJ6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRT2: NX_Q8IXJ6

Explore proteomics data for SIRT2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at the G2/M transition of the cell cycle
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXJ6

  • SIRT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIRT2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001180215.1  NP_036369.2  NP_085096.1  

    ENSEMBL proteins: 
     ENSP00000249396   ENSP00000375931   ENSP00000404309   ENSP00000400338   ENSP00000411393  
     ENSP00000385146   ENSP00000401203   ENSP00000407272   ENSP00000409690   ENSP00000397022  
     ENSP00000408023   ENSP00000351809  

    Human Recombinant Protein Products for SIRT2: 
    EMD Millipore Purified and/or Recombinant SIRT2 Protein
    R&D Systems Recombinant & Natural Proteins for SIRT2 (Sirtuin 2/SIRT2)
    Enzo Life Sciences proteins for SIRT2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SIRT2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SIRT2
    GenScript Custom Purified and Recombinant Proteins Services for SIRT2
    Novus Biologicals SIRT2 Proteins
    Novus Biologicals SIRT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SIRT2
    Cloud-Clone Corp. Proteins for SIRT2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005677chromatin silencing complex NAS12697818
    GO:0005737cytoplasm IDA12697818
    GO:0005874microtubule IDA12620231

    SIRT2 for ontologies           About GeneDecksing



    SIRT2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SIRT2
    R&D Systems Antibodies for SIRT2 (Sirtuin 2/SIRT2)
    Cell Signaling Technology (CST) Antibodies for SIRT2 
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    OriGene Custom Antibody Services for SIRT2
    GenScript Custom Superior Antibodies Services for SIRT2
    Novus Biologicals SIRT2 Antibodies
    Abcam antibodies for SIRT2
    Cloud-Clone Corp. Antibodies for SIRT2 
    ThermoFisher Antibody for SIRT2
    LSBio Antibodies in human, mouse, rat for SIRT2 

    Assay Products for SIRT2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SIRT2
    R&D Systems Proteome Profiler Antibody Arrays for SIRT2 (Sirtuin 2/SIRT2)
    GenScript Custom Assay Services for SIRT2
    Enzo Life Sciences assays for SIRT2
    Cloud-Clone Corp. ELISAs for SIRT2 
    Cloud-Clone Corp. CLIAs for SIRT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR017328 NAD-dep_deAcase_SIR2_class_I
     IPR003000 Sirtuin
     IPR026590 Ssirtuin_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8IXJ6

    ProtoNet protein and cluster: Q8IXJ6

    1 Blocks protein domain: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6
    Similarity: Belongs to the sirtuin family. Class I subfamily
    Similarity: Contains 1 deacetylase sirtuin-type domain


    SIRT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIR2_HUMAN, Q8IXJ6
    Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone
    proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle,
    probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation.
    Deacetylates 'Lys-310' of RELA
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein
    Enzyme regulation: Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide

         Enzyme Number (IUBMB): EC 3.5.1.-1

         Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003950NOT NAD+ ADP-ribosyltransferase activity TAS17456799
    GO:0005515protein binding IPI12697818
    GO:0008134transcription factor binding IPI12887892
    GO:0008270zinc ion binding IDA11427894
    GO:0016811hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
         
    SIRT2 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Sirt2):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     nervous system  normal  other  tumorigenesis 

    SIRT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SIRT2: Sirt2tm1Gdon Sirt2tm1.2Jmi Sirt2tm1.1Cxd Sirt2tm1.1Fwa

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIRT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIRT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SIRT2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT2
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT2:
    hsa-miR-4303 hsa-miR-4283 hsa-miR-1303 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSIRT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SIRT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SIRT2
    Sirion Biotech Customized adenovirus for overexpression of SIRT2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SIRT2 (see all 15)
    OriGene ORF clones in mouse, rat for SIRT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SIRT2 (NM_030593)
    Sino Biological Human cDNA Clone for SIRT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT2
    Sirion Biotech Customized lentivirus for stable overexpression of SIRT2 
                         Customized lentivirus expression plasmids for stable overexpression of SIRT2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SIRT2
    Search LifeMap BioReagents cell lines for SIRT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIRT2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p53 Pathway
    p53 Signaling0.38
    p53 Pathway0.38
    2NAD metabolism
    NAD metabolism0.43
    3Non-homologous end-joining
    DNA damage NHEJ mechanisms of DSBs repair0.37
    4Signal transduction Activin A signaling regulation
    Histone modification0.31
    54-1BB Pathway
    SUMO Pathway0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for SIRT2
        NAD metabolism
    Histone modification
    DNA damage NHEJ mechanisms of DSBs repair

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT2
        p53 Signaling
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for SIRT2
        Chromatin Regulation / Acetylation

    2 GeneGo (Thomson Reuters) Pathways for SIRT2
        NAD metabolism
    DNA damage NHEJ mechanisms of DSBs repair

    2 BioSystems Pathways for SIRT2
        Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class III

    1 Sino Biological Pathway for SIRT2 
        p53 Pathway



    SIRT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIRT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/134 Interacting proteins for SIRT2 (Q8IXJ61, 2, 3 ENSP000002493964) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000183chromatin silencing at rDNA NAS11427894
    GO:0006342chromatin silencing NAS12697818
    GO:0006348chromatin silencing at telomere NAS11427894
    GO:0006471NOT protein ADP-ribosylation TAS17456799
    GO:0006476protein deacetylation IDA17172643

    SIRT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SIRT2 for compounds           About GeneDecksing

    EMD Millipore small molecules for SIRT2:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for SIRT2

    Compounds for SIRT2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    AK 7Selective SIRT2 inhibitor; brain penetrant[420831-40-9]
    SplitomicinSir2p inhibitor[5690-03-9]
    AGK 2Selective SIRT2 inhibitor[304896-28-4]

    1 HMDB Compound for SIRT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--

    1 Novoseek inferred chemical compound relationship for SIRT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nad+ 67.4 9 19060927 (1), 16211212 (1), 17628866 (1)

    Search CenterWatch for drugs/clinical trials and news about SIRT2 / SIR2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIRT2 gene (3 alternative transcripts): 
    NM_001193286.1  NM_012237.3  NM_030593.2  

    Unigene Cluster for SIRT2:

    Sirtuin 2
    Hs.466693  [show with all ESTs]
    Unigene Representative Sequence: NM_012237
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479290 ENST00000462654(uc010egi.2 uc002ojs.2) ENST00000249396(uc002ojt.2 uc002ojv.2)
    ENST00000392081(uc002oju.2 uc010egh.2) ENST00000496069 ENST00000414941
    ENST00000420440 ENST00000443898 ENST00000407552 ENST00000381766 ENST00000491960
    ENST00000476771 ENST00000451193 ENST00000423526 ENST00000437828 ENST00000447739
    ENST00000481381 ENST00000358931

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT2:
    hsa-miR-4303 hsa-miR-4283 hsa-miR-1303 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidSIRT2 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT2

    Additional mRNA sequence: 

    AB009274.1 AF083107.2 AF095714.1 AF131800.1 AF160214.1 AK025876.1 AK054642.1 AK225824.1 
    AK290716.1 AK314492.1 AY030277.1 BC003012.1 BC003547.1 NR_034146.1 

    24/27 DOTS entries (see all 27):

    DT.100883254  DT.447660  DT.100883257  DT.100883265  DT.100883250  DT.86854504  DT.99958966  DT.429673 
    DT.95281347  DT.97855683  DT.100883271  DT.100883270  DT.121500146  DT.75198292  DT.100030658  DT.100883272 
    DT.102830215  DT.91841242  DT.95105807  DT.98131735  DT.99936055  DT.100883252  DT.121500101  DT.91779085 

    24/544 AceView cDNA sequences (see all 544):

    BM837612 BM784187 BI907256 BM547962 AA366595 AL079367 CF264878 AL556451 
    BM698473 AI826678 BI918160 CR598693 AL583280 CD515711 BQ221442 BI768954 
    BQ645221 BG437042 BM743842 BQ068347 BI907019 CD671289 BQ068262 BI762228 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i · 1j · 1k ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ·
    SP1:                                                                    -           -     -     -           -           -                             -     -   
    SP2:                                                                    -           -     -     -           -           -                             -     -   
    SP3:                                                                    -     -     -     -     -           -           -                             -     -   
    SP4:                                                                                                                    -                             -     -   
    SP5:                                                                                                        -           -                             -     -   

    ExUns: 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
    SP1:  -                                                           -                     
    SP2:  -                                                           -                     
    SP3:  -                                                           -                     
    SP4:  -                                                           -                     
    SP5:  -                                         -     -     -     -     -               


    ECgene alternative splicing isoforms for SIRT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIRT2 expression in normal human tissues (normalized intensities)      SIRT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGATGGGC
    SIRT2 Expression
    About this image


    SIRT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Bone (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Blood (Muscoskeletal System)
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
     
     Mesenchymal Stem Cells
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   

    See SIRT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIRT2

    SOURCE GeneReport for Unigene cluster: Hs.466693

    UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6
    Tissue specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly
    expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor
    gene in human gliomas possibly through the regulation of microtubule network

        SABiosciences Expression via Pathway-Focused PCR Arrays including SIRT2 (see all 6): 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Telomeres & Telomerase in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SIRT2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sirt21 , 5 sirtuin 2 (silent mating type information regulation more1, 5 85.86(n)1
    87.66(a)1
      7 (16.92 cM)5
    643831  NM_022432.41  NP_071877.31 
     287667355 
    chicken
    (Gallus gallus)
    Aves SIRT21 sirtuin 2 73.39(n)
    74.56(a)
      548628  NM_001017414.1  NP_001017414.1 
    lizard
    (Anolis carolinensis)
    Reptilia SIRT26
    sirtuin 2
    65(a)
    1 ↔ 1
    GL343885.1(18663-30561)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF522612.12   -- 73.4(n)    CF522612.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb57d052 wufb57d05 77.05(n)   322309  BC045510.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50853
    Sirt21
    NAD-dependent histone deacetylase3
    CG5085-PA1
    49(a)3
    55.95(n)1
    51.46(a)1
      92E33
    424141  NM_142623.31  NP_650880.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HST21 Hst2p 49.76(n)
    47.45(a)
      856092   NP_015310.1 


    ENSEMBL Gene Tree for SIRT2 (if available)
    TreeFam Gene Tree for SIRT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIRT2 gene
    SIRT42  SIRT32  SIRT52  
    3 SIMAP similar genes for SIRT2 using alignment to 10 protein entries:     SIR2_HUMAN (see all proteins):
    SIR2    SIRT3    SIRT1

    SIRT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in SIRT2 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72497931,2
    C--39371013(+) AGACCC/TAGAGC 4 -- int14Minor allele frequency- T:0.22WA NA EA 360
    rs72496751,2
    C,F,A--39371014(+) GACCCA/GGAGCG 4 -- int15Minor allele frequency- G:0.34WA CSA NA EA 362
    rs1860541801,2
    --39371039(+) CCCCCC/GGCACT 4 -- int10--------
    rs169728621,2
    C,F--39371122(+) CTGGTT/GTGAGT 4 -- int17Minor allele frequency- G:0.09NA CSA WA 377
    rs1898387161,2
    C--39371289(+) GGGGAA/GCCTGT 4 -- int10--------
    rs2014311981,2
    --39371353(+) TGAGCA/GGGCGA 6 P L mis1 int10--------
    rs2007775381,2
    C--39371374(+) GGGGTA/GCCCTG 6 A V mis1 int10--------
    rs1120098201,2
    C,F--39371446(+) AGCCAC/TAGCCC 4 -- int12Minor allele frequency- T:0.01CSA EU 1024
    rs1388054951,2
    C--39371459(+) AACCTA/GCTTGC 4 -- spd1 int11Minor allele frequency- G:0.00NA 4468
    rs2007294061,2
    --39371499(+) AAGGAA/GGTACC 7 T syn10--------

    HapMap Linkage Disequilibrium report for SIRT2 (39369195 - 39390502 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SIRT2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SIRT2
    DNA2.0 Custom Variant and Variant Library Synthesis for SIRT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604480    OMIM disorders: --

    16 diseases for SIRT2:    About MalaCards
    lip cancer    multiple system atrophy    temporal lobe epilepsy    mood disorder
    obesity, association with    huntington's disease    parkinson's disease    multiple sclerosis
    alcoholism    tuberculosis    diabetes mellitus    obesity
    melanoma    prostate cancer    hepatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SIRT2:
    Diabetes mellitus

    SIRT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SIRT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 5.16 5 19060927 (1), 19559674 (1), 10393250 (1)
    tumors 0 3 16211212 (1), 12963026 (1), 19559674 (1)

    Human Genome Epidemiology (HuGE) Navigator: SIRT2 (1 document)

    Export disorders for SIRT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIRT2 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with SIRT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. (PubMed id 10393250)1, 2, 3, 9 Afshar G. and Murnane J.P. (1999)
    2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)1, 2, 3 Frye R.A. (1999)
    3. Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. (PubMed id 12697818)1, 2, 9 Dryden S.C.... Tainsky M.A. (2003)
    4. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PubMed id 12620231)1, 2, 9 North B.J.... Verdin E. (2003)
    5. Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. (PubMed id 12963026)1, 2, 9 Hiratsuka M....Oshimura M. (2003)
    6. Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1, 2 Jiang W....Zhao S. (2011)
    7. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)1, 2 Michishita E.... Horikawa I. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Conserved enzymatic production and biological effect of O-acetyl-ADP- ribose by silent information regulator 2-like NAD+-dependent deacetylases. (PubMed id 11812793)1, 2 Borra M.T.... Denu J.M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22933 HGNC: 10886 AceView: SIRT2 Ensembl:ENSG00000068903 euGenes: HUgn22933
    ECgene: SIRT2 H-InvDB: SIRT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIRT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIRT2 gene:
    Search GeneIP for patents involving SIRT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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