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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SIRT2 Gene

protein-coding GIFtS: 65
GCID: GC19M039369

sirtuin 2

(Previous names: sirtuin (silent mating type information regulation 2, S.cerevisiae,...)
(Previous symbol: SIR2L)

Explore 14 diseases affiliated with
SIRT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sirtuin 2¹ ²		SIR2²
SIR2L¹ ² ³ ⁵		NAD-Dependent Deacetylase Sirtuin-2²
SIR2L2² ³ ⁵		NAD-Dependent Protein Deacetylase Sirtuin-2²
Regulatory Protein SIR2 Homolog 2² ³		Silent Information Regulator 2²
SIR2-Like Protein 2² ³		Sir2-Related Protein Type 2²
Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 2 (S. Cerevisiae)¹		Sirtuin Type 2²
Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 2¹		EC 3.5.1.-³

External Ids:	HGNC: 10886¹	Entrez Gene: 22933²	Ensembl: ENSG00000068903⁷	OMIM: 604480⁵	UniProtKB: Q8IXJ6³

ORGUL members:
	NONCODE:n409745

Export aliases for SIRT2 gene to outside databases

Previous GC identifers: GC19M039981 GC19M039760 GC19M044045 GC19M044061 GC19M035815

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRT2:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the

sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human

sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing

and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory

proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the

sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. (provided by RefSeq,

Jul 2010)

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6

Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins.

Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its

role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of

RELA

summary for SIRT2:

Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes

closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or

nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups

from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general,

sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and

mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of

transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible

antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process

through their role in resistance to cellular stress.

Gene Wiki entry for SIRT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIRT2 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SIRT2 promoter sequence

Search SABiosciences Chromatin IP Primers for SIRT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13

SIRT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRT2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M039369: view genomic region (about GC identifiers)

Start:	39,369,195 bp from pter	End:	39,390,502 bp from pter
Size:	21,308 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6 (See protein sequence)

Recommended Name: NAD-dependent protein deacetylase sirtuin-2

Size: 389 amino acids; 43182 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the

cytoskeleton

Subcellular location: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules

Developmental stage: Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome

Miscellaneous: Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely

in vivo

Sequence caution: Sequence=AAD45971.1; Type=Erroneous initiation; Sequence=AAF67015.1; Type=Frameshift;

Positions=Several;

1 PDB 3D structure from and Proteopedia for SIRT2:

1J8F (3D)

Secondary accessions: A8K3V1 B2RB45 O95889 Q924Y7 Q9P0G8 Q9UNT0 Q9Y6E9

Alternative splicing: 4 isoforms: Q8IXJ6-1 Q8IXJ6-2 Q8IXJ6-3 Q8IXJ6-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRT2: NX_Q8IXJ6

Post-translational modifications:

Phosphorylated at the G2/M transition of the cell cycle¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IXJ6

SIRT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001180215.1 NP_036369.2 NP_085096.1

ENSEMBL proteins:

ENSP00000249396 ENSP00000375931 ENSP00000404309 ENSP00000400338 ENSP00000411393

ENSP00000385146 ENSP00000401203 ENSP00000407272 ENSP00000409690 ENSP00000397022

ENSP00000408023 ENSP00000351809

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant SIRT2 Protein
	R&D Systems Recombinant & Natural Proteins for SIRT2 (Sirtuin 2/SIRT2)
	Enzo Life Sciences proteins for SIRT2
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): SIRT2 OriGene Custom Protein Services for SIRT2
	GenScript Custom Purified and Recombinant Proteins Services for SIRT2
	Novus Biologicals SIRT2 Proteins Novus Biologicals SIRT2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SIRT2
	Uscn Proteins for SIRT2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005677	chromatin silencing complex	NAS	12697818
GO:0005737	cytoplasm	IDA	16079181
GO:0005874	microtubule	IDA	12620231

SIRT2 for ontologies About GeneDecksing

SIRT2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SIRT2
	R&D Systems Antibodies for SIRT2 (Sirtuin 2/SIRT2)
	OriGene Antibodies (see all 4): SIRT2 OriGene Custom Antibody Services for SIRT2
	GenScript Custom Superior Antibodies Services for SIRT2
	Novus Biologicals SIRT2 Antibodies
	Abcam antibodies for SIRT2
	Uscn Antibodies for SIRT2
	ThermoFisher Antibody for SIRT2

Assay Products for SIRT2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for SIRT2 (Sirtuin 2/SIRT2)
	GenScript Custom Assay Services for SIRT2
	Enzo Life Sciences assays for SIRT2
	Uscn ELISAs and CLIAs for SIRT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIRT2 for domains About GeneDecksing

3 InterPro domains/families:

IPR017328 NAD-dep_deAcase_SIR2_class_I

IPR003000 Sirtuin

IPR026590 Ssirtuin_cat_dom

Graphical View of Domain Structure for InterPro Entry Q8IXJ6

ProtoNet protein and cluster: Q8IXJ6

1 Blocks protein family: IPB003000 Silent information regulator protein Sir2

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6

Similarity: Belongs to the sirtuin family. Class I subfamily

Similarity: Contains 1 deacetylase sirtuin-type domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6

Function: NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins.

Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its

role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of

RELA

Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein

Enzyme regulation: Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide

Enzyme Number (IUBMB): EC 3.5.1.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SIRT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT2:
		hsa-miR-4303 hsa-miR-4283 hsa-miR-1303 hsa-miR-24
		SwitchGear 3'UTR luciferase reporter plasmid: SIRT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRT2 (see all 7) OriGene shRNA RFP: SIRT2 OriGene siRNA: SIRT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SIRT2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SIRT2 (NM_030593)
		Sino Biological Human cDNA Clone for SIRT2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SIRT2
		Search LifeMap BioReagents cell lines for SIRT2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT2

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003950	NOT NAD+ ADP-ribosyltransferase activity	TAS	17456799
GO:0005515	protein binding	IPI	--
GO:0008134	transcription factor binding	IPI	15126506
GO:0008270	zinc ion binding	IDA	11427894
GO:0017136	NAD-dependent histone deacetylase activity	IDA	11427894

SIRT2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for SIRT2: Sirt2^tm1Gbp Sirt2^tm1.1Cxd Sirt2^tm1.1Fwa
     14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Sirt2):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	nervous system
no phenotypic analysis	normal	other	tumorigenesis

SIRT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

NAD metabolism

NAD metabolism

1.00

NAD metabolism

1.00

Non-homologous end-joining

DNA damage NHEJ mechanisms of DSBs repair

0.36

DNA damage_NHEJ mechanisms of DSBs repair

0.36

Signaling events mediated by HDAC Class I

Signaling events mediated by HDAC Class I

1.00

Signaling events mediated by HDAC Class III

Signaling events mediated by HDAC Class III

1.00

Chks in Checkpoint Regulation

p53 Signaling

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for SIRT2

	NAD metabolism
	Histone modification
	DNA damage NHEJ mechanisms of DSBs repair

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SIRT2

	p53 Signaling
	SUMO Pathway

2 GeneGo (Thomson Reuters) Pathways for SIRT2

	NAD metabolism
	DNA damage NHEJ mechanisms of DSBs repair

2 BioSystems Pathways for SIRT2

	Signaling events mediated by HDAC Class I
	Signaling events mediated by HDAC Class III

SIRT2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIRT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for SIRT2 (Q8IXJ6^{1, 2, 3} ENSP00000249396⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³, ENSP00000350275⁴	I2D: score=1 STRING: ENSP00000350275
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000183	chromatin silencing at rDNA	NAS	11427894
GO:0006342	chromatin silencing	NAS	12697818
GO:0006348	chromatin silencing at telomere	NAS	11427894
GO:0006471	NOT protein ADP-ribosylation	TAS	17456799
GO:0006476	protein deacetylation	IDA	17172643

SIRT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SIRT2 for compounds About GeneDecksing

EMD Millipore small molecules for SIRT2:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for SIRT2

Compounds for SIRT2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Sirtinol	Selective sirtuin family deacetylase inhibitor	[410536-97-9]
AGK 2	Selective SIRT2 inhibitor	[304896-28-4]
Salermide	SIRT1 and SIRT2 inhibitor	[1105698-15-4]
Splitomicin	Sir2p inhibitor	[5690-03-9]

1 HMDB Compound for SIRT2 About this table

Compound	Synonyms	CAS #	PubMed Ids
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

1 Novoseek chemical compound relationship for SIRT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nad+	67.4	9	19060927 (1), 16211212 (1), 17628866 (1)

Search CenterWatch for drugs/clinical trials and news about SIRT2 / SIR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SIRT2 gene (3 alternative transcripts):

NM_001193286.1 NM_012237.3 NM_030593.2

Unigene Cluster for SIRT2:

Sirtuin 2

Hs.466693 [show with all ESTs]

Unigene Representative Sequence: NM_012237

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479290 ENST00000462654(uc010egi.2 uc002ojs.2) ENST00000249396(uc002ojt.2 uc002ojv.2)

ENST00000392081(uc002oju.2 uc010egh.2) ENST00000496069 ENST00000414941

ENST00000420440 ENST00000443898 ENST00000407552 ENST00000381766 ENST00000491960

ENST00000476771 ENST00000451193 ENST00000423526 ENST00000437828 ENST00000447739

ENST00000481381 ENST00000358931

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SIRT2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SIRT2
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate SIRT2:
		hsa-miR-4303 hsa-miR-4283 hsa-miR-1303 hsa-miR-24
		SwitchGear 3'UTR luciferase reporter plasmid: SIRT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRT2 (see all 7) OriGene shRNA RFP: SIRT2 OriGene siRNA: SIRT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRT2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRT2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SIRT2 (NM_030593)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRT2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SIRT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT2

Additional cDNA sequence:

AB009274.1 AF083107.2 AF095714.1 AF131800.1 AF160214.1 AK025876.1 AK054642.1 AK225824.1

AK290716.1 AK314492.1 AY030277.1 BC003012.1 BC003547.1 NR_034146.1

24/27 DOTS entries (see all 27):

DT.100883254 DT.447660 DT.100883257 DT.100883265 DT.100883250 DT.86854504 DT.99958966 DT.429673

DT.95281347 DT.97855683 DT.100883271 DT.100883270 DT.121500146 DT.75198292 DT.100030658 DT.100883272

DT.102830215 DT.91841242 DT.95105807 DT.98131735 DT.99936055 DT.100883252 DT.121500101 DT.91779085

24/544 AceView cDNA sequences (see all 544):

BM920249 CR598693 AL556451 BI918160 CD671289 BM790736 CR591051 BQ068347

CD675728 BE253088 BF529638 AI159833 BX367337 BM916886 BQ951302 AK131390

CD558177 CB152744 CR617711 BQ221442 BI756239 BG437042 BM698473 BI766740

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT2 (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	·	1i	·	1j	·	1k	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·
SP1:																							-				-		-		-				-				-										-		-
SP2:																							-				-		-		-				-				-										-		-
SP3:																							-		-		-		-		-				-				-										-		-
SP4:																																							-										-		-
SP5:																																			-				-										-		-

ExUns:	11c	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20	^	21
SP1:	-																				-
SP2:	-																				-
SP3:	-																				-
SP4:	-																				-
SP5:	-														-		-		-		-		-

ECgene alternative splicing isoforms for SIRT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SIRT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGATGGGC

About this image
See SIRT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRT2

SOURCE GeneReport for Unigene cluster: Hs.466693

UniProtKB/Swiss-Prot: SIR2_HUMAN, Q8IXJ6

Tissue specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly

expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene

in human gliomas possibly through the regulation of microtubule network

SABiosciences Expression via Pathway-Focused PCR Arrays including SIRT2 (see all 6):

Epigenetic Chromatin Modification Enzymes in human mouse rat

Cancer PathwayFinder in human mouse rat

Telomeres & Telomerase in human mouse rat

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRT2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SIRT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SIRT2 gene from 8/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sirt2^{1 , 5}	sirtuin 2 (silent mating type information regulation more^{1, 5}	85.86(n)¹ 87.66(a)¹		7 (16.92 cM)⁵ 64383¹ NM_022432.4¹ NP_071877.3¹ 28766735⁵
chicken (Gallus gallus)	Aves	SIRT2¹	sirtuin 2	73.39(n) 74.56(a)		548628 NM_001017414.1 NP_001017414.1
lizard (Anolis carolinensis)	Reptilia	SIRT2⁶ SIRT5⁶	--	69(a) 18(a)	1 ↔ 1 possible ortholog	GL343885.1(20281-29499) 4(57071927-57080042)
African clawed frog (Xenopus laevis)	Amphibia	CF522612.1²	--	73.4(n)		CF522612.1
zebrafish (Danio rerio)	Actinopterygii	wufb57d05²	wufb57d05	77.05(n)		322309 BC045510.1
fruit fly (Drosophila melanogaster)	Insecta	CG5085³ Sirt2¹	NAD-dependent histone deacetylase³ CG5085-PA¹	49(a)³ 55.95(n)¹ 51.46(a)¹		92E3³ 42414¹ NM_142623.3¹ NP_650880.2¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HST2¹	Hst2p	49.76(n) 47.45(a)		856092 NP_015310.1
E. coli (Escherichia coli)	Gamma proteobacteria	cobB⁶	deacetylase of acs and cheY, regulates chemotaxis	23(a)	possible ortholog	Chromosome(1178854-1179582)

ENSEMBL Gene Tree for SIRT2 (if available)
TreeFam Gene Tree for SIRT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SIRT2 gene

SIRT4² SIRT3² SIRT5²

3 SIMAP similar genes for SIRT2 using alignment to 10 protein entries: SIR2_HUMAN (see all proteins):

SIR2 SIRT3 SIRT1

SIRT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75665069^1,2		--	39368753(+)	`GTACCG/ATGGCA`	6	--	int¹ ds500¹		2		CSA EA	121
rs184359872^1,2		--	39368854(+)	`TGCTCA/GGTTCC`	6	--	int¹ ds500¹		0	--	--	--	--
rs892034^1,2	C,F,H,	--	39368998(+)	`GCCTTC/TAGTGA`	6	--	ds500¹ us2k¹		25		MN NS EA NA WA CSA	2433
rs2015^1,2	C,F,A,H,	--	39369369(-)	`TGAATA/CTAACC`	6	--	ut3¹ nc-transcript-variantus2k¹ ese³		31		NA EA MN NS WA CSA	4276
rs143456715^1,2	C,	--	39369426(+)	`CACAGA/GCCCCC`	6	--	us2k¹ ut3¹ nc-transcript-variant		0	--	--	--	--
rs189355670^1,2	C,	--	39369457(+)	`GGGCCC/TGAAGC`	6	--	us2k¹ ut3¹ nc-transcript-variant		0	--	--	--	--
rs2241703^1,2	C,F,H,	--	39369514(+)	`TGGGGG/ACAGTT`	6	--	ut3¹ nc-transcript-variantus2k¹ ese³		6		EA NS	2022
rs45592833^1,2	C,F,	--	39369635(+)	`TGGGGG/TCCAGG`	6	--	ut3¹ nc-transcript-variantus2k¹		3		WA CSA	122
rs199976060^1,2	C,F,	--	39369769(+)	`AGCTCG/AGCATC`	6	--	us2k¹ ut3¹ nc-transcript-variant		1		EU	855
rs113734329^1,2	C,F	--	39369847(+)	`GTGGCG/AGGGAC`	8	/P /L	us2k¹ mis¹ ut3¹		2		CSA NA	4546

HapMap Linkage Disequilibrium report for SIRT2 (39369195 - 39390502 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIRT2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIRT2 for disorders           About GeneDecksing

OMIM gene information: 604480    OMIM disorders: --

14 diseases for SIRT2:    About MalaCards

temporal lobe epilepsy multiple system atrophy mood disorder lip cancer

multiple sclerosis huntington's disease skin cancer parkinson's disease

copd tuberculosis melanoma hepatitis

mycobacterium tuberculosis alcoholism

1 disease from the University of Copenhagen DISEASES database for SIRT2:

Diabetes mellitus

2 Novoseek disease relationships for SIRT2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	5.16	5	19060927 (1), 19559674 (1), 10393250 (1)
tumors	0	3	16211212 (1), 12963026 (1), 19559674 (1)

Human Genome Epidemiology (HuGE) Navigator: SIRT2 (1 document)

Export disorders for SIRT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SIRT2 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with SIRT2)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2. (PubMed id 10393250)^{1, 2, 3, 9} Afshar G. and Murnane J.P. (1999)
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PubMed id 10381378)^{1, 2, 3} Frye R.A. (1999)
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. (PubMed id 12697818)^{1, 2, 9} Dryden S.C.... Tainsky M.A. (2003)
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PubMed id 12620231)^{1, 2, 9} North B.J.... Verdin E. (2003)
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. (PubMed id 12963026)^{1, 2, 9} Hiratsuka M....Oshimura M. (2003)
Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)^{1, 2} Jiang W....Zhao S. (2011)
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PubMed id 16079181)^{1, 2} Michishita E.... Horikawa I. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Conserved enzymatic production and biological effect of O-acetyl-ADP- ribose by silent information regulator 2-like NAD+-dependent deacetylases. (PubMed id 11812793)^{1, 2} Borra M.T.... Denu J.M. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22933	HGNC: 10886	AceView: SIRT2	Ensembl:ENSG00000068903	euGenes: HUgn22933
ECgene: SIRT2	H-InvDB: SIRT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SIRT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SIRT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SIRT2 gene:
Search GeneIP for patents involving SIRT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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