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SIRT1 Gene

protein-coding   GIFtS: 66

GC10P069314
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
(Previous names: sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for SIRT1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EC 3.5.1.- 3
OTTHUMP00000019691 2
OTTHUMP00000060745 2
SIR2L1 1, 2, 3, 5
SIR2alpha 2
hSIR2 3
hSIRT1 3
Descriptions
SIR2-like protein 1 3
sir2-like 1 2
sirtuin (silent mating type information regulation 2
homolog) 1 (S. cerevisiae) 2
sirtuin (silent mating type information regulation 2, S.
cerevisiae, homolog) 1 1
sirtuin 1 2
sirtuin type 1 2
External Ids
HGNC: 149291
Entrez Gene: 234112
UniProtKB: Q96EB63
Ensembl: ENSG000000967177
Search outside databases for aliases for SIRT1 gene

Previous GC identifers: GC10P068455 GC10P068731 GC10P069536 GC10P068989

Summaries
for SIRT1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for SIRT1:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein.
Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four
classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin
proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.
Studies suggest that the human sirtuins may function as intracellular regulatory proteins with
mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of
the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by
RefSeq]

UniProtKB/Swiss-Prot: SIRT1_HUMAN, Q96EB6
Function: NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle
differentiation by deacetylating key proteins. Deacetylates 'Lys-382' of p53/TP53 and impairs its
ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and
thereby represses rDNA transcription by the RNA polymerase I. Involved in HES1- and HEY2-mediated
transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and
MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal
muscle cell differentiation. Despite some ability to deacetylate histones in vitro, such activity
is either weak or inexistent in vivo. In case of HIV-1 infection, interacts with and deacetylates
the viral Tat protein

Gene Wiki entry for SIRT1 (Sirtuin_1)

Genomic Location
for SIRT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SIRT1 gene  

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q21

SIRT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P069314:     (about GC identifiers)

Start:
 69,314,433 bp from pter
End:
 69,348,153 bp from pter
Size:
 33,721 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000010.9  NT_008583.16  

Proteins
for SIRT1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SIRT1_HUMAN, Q96EB6 (See protein sequence)
Recommended Name: NAD-dependent deacetylase sirtuin-1  
Size: 747 amino acids; 81681 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with TAF1B. Found in a complex with PCAF and MYOD1 (By similarity). Interacts
with MLLT7/FOXO4, HES1, HEY2, p53/TP53 and PML. Interacts with RPS19BP1/AROS
Subcellular location: Nucleus. Note=Recruited to the nuclear bodies via its interaction with PML
Miscellaneous: Red wine, which contains resveratrol, may participate in activation of sirtuin
proteins, and may therefore participate in an extended lifespan as it has been observed in yeast
Secondary accessions: Q2XNF6 Q5JVQ0 Q9GZR9 Q9Y6F0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001135970.1  NP_036370.2  


    ENSEMBL proteins: 
    ENSP00000384063 ENSP00000384508 ENSP00000212015 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant SIRT1 Protein
    Sigma-Aldrich Proteins for SIRT1  
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SIRT1
    Recombinant Proteins from Abcam (SIRT1)
    Human Recombinant Proteins from Abnova (SIRT1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005635 nuclear envelope IDA15469825
    GO:0005730 nucleolus IDA15469825
    GO:0005737NOT cytoplasm IDA15469825
    GO:0016605 PML body IDA12006491
    About this table

    Antibodies for SIRT1: 
    Invitrogen Antibodies for SIRT1
    Millipore Mono- and Polyclonal Antibodies for the study of SIRT1
    Sigma-Aldrich Antibodies for SIRT1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SIRT1 
    Antibodies from Abcam (SIRT1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for SIRT1

    Assays for SIRT1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Enzo Life Sciences assays for SIRT1

    Protein Domains/
    Families
    for SIRT1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR003000 NAD-dep_histone_deAcase_SIR2


       GeneDecks  SIRT1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q96EB6

    ProtoNet protein and cluster: Q96EB6

    1 Blocks protein family: IPB003000 Silent information regulator protein Sir2

    UniProtKB/Swiss-Prot: SIRT1_HUMAN, Q96EB6
    Similarity: Belongs to the sirtuin family
    Similarity: Contains 1 deacetylase sirtuin-type domain

    Gene Function
    for SIRT1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SIRT1)
    Millipore RNAi Products for the Analysis of SIRT1 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (SIRT1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001142498

                  Applied Biosystems Silencer® siRNAs for SIRT1

                  Sigma-Aldrich siRNA and siRNA Panels for SIRT1  
                         Sigma-Aldrich shRNA Panels and shRNA for SIRT1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142498
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142498
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001142498 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_012238

    UniProtKB/Swiss-Prot: SIRT1_HUMAN, Q96EB6
    Function: NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle
    differentiation by deacetylating key proteins. Deacetylates 'Lys-382' of p53/TP53 and impairs its
    ability to induce proapoptotic program and modulate cell senescence. Deacetylates TAF1B and
    thereby represses rDNA transcription by the RNA polymerase I. Involved in HES1- and HEY2-mediated
    transcriptional repression. Inhibits skeletal muscle differentiation by deacetylating PCAF and
    MYOD1. May serve as a sensor of the cytosolic ratio of NAD(+)/NADH, which is essential in skeletal
    muscle cell differentiation. Despite some ability to deacetylate histones in vitro, such activity
    is either weak or inexistent in vivo. In case of HIV-1 infection, interacts with and deacetylates
    the viral Tat protein
    Catalytic activity: NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein
    Enzyme regulation: Inhibited by nicotinamide. Activated by resveratrol
    (3,5,4'-trihydroxy-trans-stilbene), butein (3,4,2',4'-tetrahydroxychalcone), piceatannol
    (3,5,3',4'-tetrahydroxy-trans-stilbene), Isoliquiritigenin (4,2',4'-trihydroxychalcone), fisetin
    (3,7,3',4'-tetrahydroxyflavone) and quercetin (3,5,7,3',4'-pentahydroxyflavone). RPS19BP1/AROS
    acts as a positive regulator of deacetylation activity
    Enzyme Number (IUBMB): EC 3.5.1.- 

    15/23 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Sirt1) (see all 23 ):

    adipose tissuebehavior/neurologicalcellularcraniofacial
    digestive/alimentaryembryogenesisendocrine/exocrine glandgrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aging

    5/12 Gene Ontology (GO) molecular function terms (links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039 p53 binding IEA--
    GO:0003677 DNA binding IEA--
    GO:0003714 transcription corepressor activity IEA--
    GO:0003950NOT NAD+ ADP-ribosyltransferase activity TAS17456799
    GO:0008022 protein C-terminus binding IPI18203716
    About this table

    Pathways & Interactions
    for SIRT1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    3 Millipore Pathways for SIRT1
     NAD metabolism
     Histone modification
     DNA damage NHEJ mechanisms of DSBs repair

       GeneDecks  SIRT1 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SIRT1  (Your Favorite Gene powered by Ingenuity) 
     p53 Signaling

       GeneDecks  SIRT1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  SIRT1 


    5/116 Interacting proteins for SIRT1 (ENSP000002120153 Q96EB61, 2) via UniProtKB, MINT, and/or STRING (see all 116 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA0409O431591EBI-1802965, EBI-2008793
    Arntl Arntl (xeno)Q9WTL8-21EBI-1802965, EBI-644559
    Per2 Per2 (xeno)O549431EBI-1802965, EBI-1266779
    ATP1A1P050232MINT-6488488
    DDOSTP396562MINT-6488488
    About this table

    5/30 Gene Ontology (GO) biological process terms (links to tree view) (see all 30 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542 ovulation from ovarian follicle IEA--
    GO:0006260 DNA replication TAS17317627
    GO:0006281 DNA repair TAS17317627
    GO:0006343 establishment of chromatin silencing IDA15469825
    GO:0006344 maintenance of chromatin silencing IMP15469825
    About this table

    Drugs & Compounds
    for SIRT1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for SIRT1
    Sigma-Aldrich Small Molecules for SIRT1:
    Inhibitor

    Compounds for SIRT1 available from Tocris Bioscience
    CompoundAction CAS number
    SirtinolSelective sirtuin family deacetylase inhibitor[410536-97-9]
    EX 527Selective SIRT1 inhibitor[49843-98-3]
    SplitomicinSir2p inhibitor[5690-03-9]
    About this table


    8 Novoseek chemical compound relationships for SIRT1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    nad+ 73.81 27 17595514 (2), 19188449 (2), 16328012 (1), 19060927 (1) (see all 9)
    lysine 49.17 2 15744310 (1), 17098745 (1)
    nadh 32.86 1 19188449 (1)
    lipid 15.29 8 17936707 (2), 17646659 (2), 18820948 (1), 18239056 (1) (see all 5)
    fatty acid 9.52 6 17646659 (2), 18709650 (1)
    glucose 6.45 19 18423418 (4), 19071085 (3), 17646659 (3), 15744310 (3) (see all 8)
    oxygen 0.00 1 18922599 (1), 19303870 (1)
    nitric oxide 0.00 1 19260974 (1), 19149606 (1)
    About this table


    Transcripts
    for SIRT1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (SIRT1)
    Millipore RNAi Products for the Analysis of SIRT1 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (SIRT1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001142498

                  Sigma-Aldrich siRNA and siRNA Panels for SIRT1  
                         Sigma-Aldrich shRNA Panels and shRNA for SIRT1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001142498  NM_012238  

    REFSEQ mRNAs for SIRT1 gene (2 alternative transcripts): 

    NM_001142498.1   NM_012238.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001142498  NM_012238  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001142498
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001142498
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001142498 

    Additional cDNA sequence: 

    AF083106.2 AF235040.1 AK027686.1 AK074805.1 AK289743.1 AL136741.1 BC012499.1 BX648554.1 

    7 DOTS entries:

    DT.312320  DT.100749000  DT.97824709  DT.100748999  DT.100658352  DT.91751505  DT.121247108 

    24/87 AceView cDNA sequences (see all 87 ):

    AF235040 BU186744 BQ219206 AI367389 AA461259 BF445130 BM980158 CK820052 
    BM273130 AI282390 BU735905 BM354077 BQ632248 AA828109 NM_012238 AF083106 
    AW615289 AA452304 AA608812 BQ025488 AI378978 AW007728 BI520244 R86123 

    highest scoring ESTs for SIRT1:

    AA460952 AI381553 AL042303 AA044634 AA044761 AA251252 AA452304 AA608812 AA782231 AA971929 

    Unigene Cluster for SIRT1:

    Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
    Hs.369779  [show with all ESTs]
    Unigene Representative Sequence: NM_012238


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SIRT1 (see all 6 )

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:                                                  -                                                   
    SP2:                                                                                                      
    SP3:                                                  -     -                                             
    SP4:                                                  -     -                                             
    SP5:              -     -     -                       -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for SIRT1

    3 Ensembl transcripts including schematic representations:
    ENST00000403579  ENST00000406900  ENST00000212015  

    Expression
    for SIRT1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SIRT1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SIRT1

    1 / 2 / 3

    5 probe-sets matching SIRT1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    46399_at2, 3 U95-B 1 1.00 1.00 0.92 0.79 AI381553 1.00 1.00 1.00 1

    		64265_s_at2, 3 U95-C 1 1.00 1.00 0.95 1.17 AA460952 1.00 1.00 1.00 1
    61678_at2, 3 U95-C 1 1.00 1.00 0.95 1.04 AL042303 1.00 1.00 1.00 1

    		218878_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_012238 0.60 1.00 0.82 1

    		218878_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  SIRT1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.369779

    UniProtKB/Swiss-Prot: SIRT1_HUMAN, Q96EB6
    Tissue specificity: Widely expressed

    Orthologs
    for SIRT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SIRT1 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 SIRT11   -- sirtuin (silent mating type information regulation more 92.22(n)
    92.17(a)    		 489012  XM_546130.2  XP_546130.2 
    cow
    (Bos taurus)    		 SIRT11   -- sirtuin (silent mating type information regulation more 91.39(n)
    90.98(a)    		 613629  XM_864818.2  XP_869911.1 
    rat
    (Rattus norvegicus)    		 Sirt11   -- sirtuin (silent mating type information regulation more 89.96(n)
    91.56(a)    		 309757  XM_228146.4  XP_228146.4 
    mouse
    (Mus musculus)    		 Sirt11, 5 105
    		 sirtuin 1 (silent mating type information regulation more1, 5 87.43(n)1
    88.48(a)1    		 937591  NM_019812.11  NP_062786.11 
     AA1990125  AA6732585  (see all 21)
    chicken
    (Gallus gallus)    		 SIRT11   -- sirtuin (silent mating type information regulation more 73.31(n)
    72.63(a)    		 423646  NM_001004767.1  NP_001004767.1 
    About this table        Species with no ortholog for SIRT1

    ENSEMBL Gene Tree for SIRT1

    Paralogs
    for SIRT1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SIRT1 gene
    SIRT22  SIRT32  

    SNPs/Variants
    for SIRT1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/308 NCBI SNPs in SIRT1 are shown (see all 308 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 98)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs7525781,2
    		A,C,F,H69347066(+) TGTAGT/CAATGT 1 -- ut31 ese39Minor allele frequency- C:0.03EU EA WA NS 600
    rs47467201,2
    		A,C,F,H69346836(+) AACTTT/CTGATT 1 -- ut3116Minor allele frequency- C:0.17NA EU EA WA NS 1166
    rs37583911,2
    		A,C,F,H69313348(+) TACCAT/CGGGTT 1 -- ng519Minor allele frequency- C:0.30EA EU WA NA 1672
    rs37400511,2
    		A,C,F,H69313965(+) TACTTA/GTTAAC 1 -- ng51 tfbs310Minor allele frequency- G:0.26EA EU WA NS 2074
    rs22349751,2
    		A,C,F69348084(+) AAAACC/TAGTGT 1 -- ut31 ese36Minor allele frequency- T:0.11MN NS 374
    rs127783661,2
    		C,F,H69313085(+) ATGAAC/TAGTGG 1 -- ng5112Minor allele frequency- N:0.00EU EA WA NA 986
    --
    rs23944431,2
    		A,C,F69314347(+) GCGCCG/CAGAGG 1 -- ng515Minor allele frequency- C:0.35NS 154
    --
    rs9326581,2
    		A,C,F69314223(-) gcccTT/GCCTCT 1 -- ng51 trp35Minor allele frequency- G:0.49NS 154
    rs78979091,2
    		C,F,H69346440(+) AACTCG/AATAGA 1 -- ut3116Minor allele frequency- A:0.01NA EU EA WA NS 1166
    rs10227641,2
    		C,F,H69348185(+) GTCTTG/ACAGAA 1 -- ng3114Minor allele frequency- A:0.01NA EA WA NS 770
    About this table

    HapMap Linkage Disequilibrium images for SIRT1 (up to first 250kb)

    Disorders & Mutations
    for SIRT1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 604479

    6 Novoseek disease relationships for SIRT1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 31.08 27 16596166 (3), 16288037 (3), 19149601 (2), 18838864 (2) (see all 10)
    neurodegeneration 22.70 2 17581637 (2), 17936707 (1), 19173742 (1), 18838864 (1) (see all 5)
    tumors 6.72 8 19047049 (3), 12297502 (1), 19285066 (1), 16596166 (1) (see all 6)
    metabolic disorder 4.02 3 19260974 (2), 17646659 (1)
    cardiovascular diseases 0.00 6 19260974 (2)
    stroke 0.00 1 18537630 (1)
    About this table

    1 PharmGKB disease relationship for SIRT1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    Genetic Association Database: SIRT1
    Human Genome Epidemiology Navigator: SIRT1 (11 documents)

    Medical News
    for SIRT1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SIRT1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/202 PubMed articles for SIRT1 gene (see all 202 ):

    Search for SIRT1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing SIRT1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 23411 HGNC: 14929 AceView: SIRT1 Ensembl:ENSG00000096717 euGenes: HUgn23411
    ECgene: SIRT1 H-InvDB: SIRT1

    Other Databases showing SIRT1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SIRT1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sirt1/

    Licensable Technologies
    for SIRT1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SIRT1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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     Assays/Drugs/Proteins for SIRT1
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