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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SIRPG Gene

protein-coding   GIFtS: 57
GCID: GC20M001558

Signal-Regulatory Protein Gamma

(Previous name: signal-regulatory protein beta 2)
(Previous symbol: SIRPB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal-Regulatory Protein Gamma1 2     CD172g Antigen2 3
SIRPB21 2 3 5     CD172g2
Signal-Regulatory Protein Beta 21 2     SIRP-B22
Signal-Regulatory Protein Beta-22 3     SIRPgamma2
SIRP-beta-22 3     bA77C3.12
SIRP-gamma2 3     SIRP Beta 22
CD172 Antigen-Like Family Member B2 3     SIRP-b23

External Ids:    HGNC: 157571   Entrez Gene: 554232   Ensembl: ENSG000000890127   OMIM: 6054665   UniProtKB: Q9P1W83   

Export aliases for SIRPG gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIRPG Gene:
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to
the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be
involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively
spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for SIRPG Gene: 
SIRPG (signal-regulatory protein gamma) is a protein-coding gene. Diseases associated with SIRPG include systemic lupus erythematosus, and type 1 diabetes, and among its related super-pathways are Cell junction organization and Platelet activation, signaling and aggregation. GO annotations related to this gene include protein binding. An important paralog of this gene is SIRPB2.

UniProtKB/Swiss-Prot: SIRPG_HUMAN, Q9P1W8
Function: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion.
Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell
proliferation and costimulates T-cell activation

Gene Wiki entry for SIRPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIRPG gene promoter:
         c-Fos   AP-1   MEF-2   NF-E2 p45   MEF-2A   aMEF-2   c-Jun   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSIRPG promoter sequence
   Search SABiosciences Chromatin IP Primers for SIRPG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SIRPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIRPG gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M001558:  view genomic region     (about GC identifiers)

Start:
1,609,798 bp from pter      End:
1,638,425 bp from pter
Size:
28,628 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIRPG_HUMAN, Q9P1W8 (See protein sequence)
Recommended Name: Signal-regulatory protein gamma precursor  
Size: 387 amino acids; 42498 Da
Subunit: Interacts with CD47
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for SIRPG:
2JJW (3D)    
Secondary accessions: B1AKP6 Q5D051 Q5JV25 Q5MKL4 Q8WWA5 Q9NQK8
Alternative splicing: 4 isoforms:  Q9P1W8-1   Q9P1W8-2   Q9P1W8-3   Q9P1W8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SIRPG: NX_Q9P1W8

Explore proteomics data for SIRPG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P1W8

  • SIRPG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SIRPG Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034597.1  NP_061026.2  NP_543006.2  

    ENSEMBL proteins: 
     ENSP00000370992   ENSP00000342759   ENSP00000305529   ENSP00000216927   ENSP00000370995  
    Reactome Protein details: Q9P1W8
    Human Recombinant Protein Products for SIRPG: 
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    Novus Biologicals SIRPG Protein
    Novus Biologicals SIRPG Lysates
    Sino Biological Recombinant Protein for SIRPG
    Sino Biological Cell Lysate for SIRPG 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane IDA15383453
    GO:0016021integral to membrane IEA--

    SIRPG for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SIRP: Signal-regulatory proteins
    CD: CD molecules
    C1SET: Immunoglobulin superfamily / C1-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry Q9P1W8

    ProtoNet protein and cluster: Q9P1W8

    UniProtKB/Swiss-Prot: SIRPG_HUMAN, Q9P1W8
    Similarity: Contains 2 Ig-like C1-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    SIRPG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIRPG_HUMAN, Q9P1W8
    Function: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion.
    Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell
    proliferation and costimulates T-cell activation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15383453
         
    SIRPG for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SIRPG:
     Decreased Salmonella enterica   Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SIRPG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SIRPG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SIRPG 
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    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRPG
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SIRPG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell-cell junction organization
    Cell-Cell communication0.64
    2Platelet activation, signaling and aggregation
    Hemostasis0.43
    3Osteoclast differentiation
    Osteoclast differentiation
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    5Signal regulatory protein (SIRP) family interactions
    Signal regulatory protein (SIRP) family interactions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for SIRPG
        Hemostasis
    Signal regulatory protein (SIRP) family interactions
    Cell-Cell communication
    Cell surface interactions at the vascular wall


    1         Kegg Pathway  (Kegg details for SIRPG):
        Osteoclast differentiation


    SIRPG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIRPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for SIRPG (Q9P1W81, 3 ENSP000003055294) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD47Q087221, 3, ENSP000003553614EBI-1268284,EBI-1268321 I2D: score=1 STRING: ENSP00000355361
    ERBB4ENSP000003422354STRING: ENSP00000342235
    IL10ENSP000004122374STRING: ENSP00000412237
    F3ENSP000003341454STRING: ENSP00000334145
    NPHS1ENSP000003681904STRING: ENSP00000368190
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007267cell-cell signaling TAS9062191
    GO:0007596blood coagulation TAS--
    GO:0008284positive regulation of cell proliferation IDA15383453
    GO:0008285negative regulation of cell proliferation TAS9062191

    SIRPG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIRPG

    Search CenterWatch for drugs/clinical trials and news about SIRPG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SIRPG gene (3 alternative transcripts): 
    NM_001039508.1  NM_018556.3  NM_080816.2  

    Unigene Cluster for SIRPG:

    Signal-regulatory protein gamma
    Hs.590883  [show with all ESTs]
    Unigene Representative Sequence: AK124224
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478145 ENST00000381580 ENST00000344103 ENST00000303415(uc002wfm.1)
    ENST00000497407 ENST00000216927 ENST00000381583(uc002wfn.1 uc002wfo.1)

    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SIRPG
    SwitchGear 3'UTR luciferase reporter plasmidSIRPG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SIRPG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRPG
    Clone
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    OriGene clones in human, mouse for SIRPG (see all 19)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SIRPG (NM_018556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SIRPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPG
    Sirion Biotech Customized lentivirus for stable overexpression of SIRPG 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRPG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRPG

    Additional mRNA sequence: 

    AB042624.1 AK124224.1 AK292745.1 AY748247.1 AY748248.1 BC020629.1 BC064532.1 

    6 DOTS entries:

    DT.208930  DT.120813881  DT.100651081  DT.120813933  DT.40113426  DT.99955863 

    22 AceView cDNA sequences:

    BX091558 BM545731 AK124224 BC020629 BC064532 AI767857 AA448081 AB042624 
    BI906236 NM_018556 NM_080816 BI909029 N77861 AA447582 AI968642 AA446468 
    AA430143 BG545450 BG198862 CD697992 CD704405 BG215091 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SIRPG (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                    -                       -     -                     
    SP2:                                            -     -                     
    SP3:                    -                 -     -     -                     
    SP4:                                                  -                     
    SP5:                    -           -     -     -     -                     


    ECgene alternative splicing isoforms for SIRPG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SIRPG expression in normal human tissues (normalized intensities)      SIRPG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATTGGGCT
    SIRPG Expression
    About this image


    SIRPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 8 entries
             T Helper Cells Thymus
             cd8+ t cell   
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus

    See SIRPG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SIRPG

    SOURCE GeneReport for Unigene cluster: Hs.590883

    UniProtKB/Swiss-Prot: SIRPG_HUMAN, Q9P1W8
    Tissue specificity: Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta
    and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells,
    and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse
    positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed
    in the medulla on mature T-lymphocytes that have undergone thymic selection

        SABiosciences Custom PCR Arrays for SIRPG
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SIRPG gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SIRPA6
    SIRPA6
    (see all 3)
    Uncharacterized protein
    (see all 3)
    36(a)
    34(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    AADN03010873.1(3381-8631)
    20(10135195-10138155)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    26(a)
    23(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    GL343515.1(139492-140536)
    GL343401.1(109012-338022)
            Species with no ortholog for SIRPG

    ENSEMBL Gene Tree for SIRPG (if available)
    TreeFam Gene Tree for SIRPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SIRPG gene
    SIRPB22  SIRPD2  SIRPB12  SIRPA2  ENSG000002608612  
    10 SIMAP similar genes for SIRPG using alignment to 2 protein entries:     SIRPG_HUMAN (see all proteins):
    SIRPB1    PTPNS1    SIRPA    SIRPD    HLA-A    HLA-B
    HLA-C    MICA    SIRPB2    HLA-DRB4

    SIRPG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/906 SNPs in SIRPG are shown (see all 906)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811060301,2
    --1609346(+) GAGGTG/TAGAAG 3 -- ds50010--------
    rs61054371,2
    C,F,H--1609355(+) AGTGTG/CCAGGT 3 -- ds500112Minor allele frequency- C:0.11NS EA WA CSA NA 1080
    rs22093121,2
    H--1609377(+) CTCAGT/CGCTCT 3 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs1179293491,2
    F--1609404(+) ACTGGC/ACCCTG 3 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1180257621,2
    C,F--1609405(+) CTGGCC/TCCTGA 3 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1426160791,2
    --1609484(+) ATGTTA/GGGGGT 3 -- ds50010--------
    rs1433638261,2
    --1609487(+) TTGGGA/GGTGAT 3 -- ds50010--------
    rs130379711,2
    C,F,A,H--1609495(+) GATTAT/CACCAC 3 -- ds500114Minor allele frequency- C:0.29NS EA NA WA 1202
    rs1856627531,2
    --1609511(+) TTGTCA/GAGTAC 3 -- ds50010--------
    rs1138930991,2
    C--1609527(+) TCAGCT/-CTTTT 3 -- ds50011Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for SIRPG (1609798 - 1638425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SIRPG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722074CNV Deletion23290073
    esv2722071CNV Deletion23290073
    nsv510779CNV Loss20534489
    nsv428374CNV Loss18775914
    dgv4516n71CNV Gain21882294
    nsv522008CNV Gain19592680
    nsv833894CNV Gain17160897
    dgv1302e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605466    OMIM disorders: --

    4 diseases for SIRPG:    About MalaCards
    systemic lupus erythematosus    type 1 diabetes    lupus erythematosus    endotheliitis


    SIRPG for disorders           About GeneDecksing

    Genetic Association Database (GAD): SIRPG
    Human Genome Epidemiology (HuGE) Navigator: SIRPG (1 document)

    Export disorders for SIRPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SIRPG gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SIRPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. (PubMed id 11185750)1, 2, 3, 9 Ichigotani Y.... Hamaguchi M. (2000)
    2. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. (PubMed id 15383453)1, 2, 9 Piccio L.... Colonna M. (2005)
    3. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (2009)
    4. A nomenclature for signal regulatory protein family m embers. (PubMed id 16339511)1, 3 van den Berg T.K....Barclay A.N. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. (PubMed id 18524990)1, 9 Stefanidakis M....Luscinskas F.W. (2008)
    8. Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. (PubMed id 15294972)1, 9 Brooke G....Barclay A.N. (2004)
    9. A genome-wide association study in Chinese men identif ies three risk loci for non-obstructive azoospermia. (PubMed id 22197933)4 Hu Z....Sha J. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55423 HGNC: 15757 AceView: SIRPB2 Ensembl:ENSG00000089012 euGenes: HUgn55423
    ECgene: SIRPG Kegg: 55423 H-InvDB: SIRPG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SIRPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SIRPG gene:
    Search GeneIP for patents involving SIRPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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