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Aliases for SIRPG Gene

Aliases for SIRPG Gene

  • Signal Regulatory Protein Gamma 2 3 5
  • CD172 Antigen-Like Family Member B 3 4
  • Signal-Regulatory Protein Beta-2 3 4
  • Signal-Regulatory Protein Gamma 2 3
  • CD172g Antigen 3 4
  • SIRP-Gamma 3 4
  • SIRP-B2 3 4
  • SIRPB2 3 4
  • Signal-Regulatory Protein Beta 2 2
  • SIRP-Beta-2 4
  • SIRP Beta 2 3
  • SIRPgamma 3
  • BA77C3.1 3
  • CD172g 3

External Ids for SIRPG Gene

Previous HGNC Symbols for SIRPG Gene

  • SIRPB2

Previous GeneCards Identifiers for SIRPG Gene

  • GC20M001558

Summaries for SIRPG Gene

Entrez Gene Summary for SIRPG Gene

  • The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRPG Gene

SIRPG (Signal Regulatory Protein Gamma) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Osteoclast differentiation. An important paralog of this gene is SIRPB1.

UniProtKB/Swiss-Prot for SIRPG Gene

  • Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Gene Wiki entry for SIRPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPG Gene

Genomics for SIRPG Gene

Regulatory Elements for SIRPG Gene

Enhancers for SIRPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F001775 1.5 FANTOM5 Ensembl ENCODE 10.9 -90.4 -90388 2.2 MLX ARID4B SIN3A ZNF48 ZNF2 SLC30A9 ZNF143 ZNF207 ZNF263 SP3 SIRPG SIRPB3P LOC100289473 LOC100533711
GH20F001566 1.4 FANTOM5 Ensembl ENCODE 10.8 +117.8 117786 4.9 CTCF ATF1 JUN BACH1 RFX5 ZNF316 NFE2 FOS CREM MAFK SIRPB1 ENSG00000271523 SIRPG SDCBP2 SIRPB2 SIRPA SIRPD
GH20F001764 1.2 FANTOM5 Ensembl ENCODE 10.8 -78.0 -78027 0.9 CTCF ZNF654 HLF WRNIP1 ARID4B MAX RAD21 TGIF2 MBD1 ZNF143 SIRPG SIRPB3P LOC100533711 LOC100289473
GH20F001731 1 Ensembl ENCODE 11.1 -45.6 -45567 1.0 HDGF MTA2 TAL1 ZBED1 JUNB ZIC2 OSR2 GATA3 GATA2 GLIS1 SIRPG ENSG00000242324 SIRPD SIRPB1 LOC105369219 PIR35224
GH20F001707 0.8 Ensembl ENCODE 11.8 -21.7 -21685 1.2 ARID1B ZNF263 KLF16 MTA2 NCOR1 TAL1 MAFK SIRPG SIRPB1 LOC105369219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRPG on UCSC Golden Path with GeneCards custom track

Genomic Location for SIRPG Gene

Chromosome:
20
Start:
1,629,152 bp from pter
End:
1,686,516 bp from pter
Size:
57,365 bases
Orientation:
Minus strand

Genomic View for SIRPG Gene

Genes around SIRPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPG Gene

Proteins for SIRPG Gene

  • Protein details for SIRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1W8-SIRPG_HUMAN
    Recommended name:
    Signal-regulatory protein gamma
    Protein Accession:
    Q9P1W8
    Secondary Accessions:
    • B1AKP6
    • Q5D051
    • Q5JV25
    • Q5MKL4
    • Q8WWA5
    • Q9NQK8

    Protein attributes for SIRPG Gene

    Size:
    387 amino acids
    Molecular mass:
    42498 Da
    Quaternary structure:
    • Interacts with CD47.

    Three dimensional structures from OCA and Proteopedia for SIRPG Gene

    Alternative splice isoforms for SIRPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPG Gene

Post-translational modifications for SIRPG Gene

  • Glycosylation at Asn 243, Asn 268, Asn 309, and Asn 317
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SIRPG (SIRP gamma/CD172g)
  • Cloud-Clone Corp. Antibodies for SIRPG

No data available for DME Specific Peptides for SIRPG Gene

Domains & Families for SIRPG Gene

Protein Domains for SIRPG Gene

Suggested Antigen Peptide Sequences for SIRPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1W8

UniProtKB/Swiss-Prot:

SIRPG_HUMAN :
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPG: view

Function for SIRPG Gene

Molecular function for SIRPG Gene

UniProtKB/Swiss-Prot Function:
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Gene Ontology (GO) - Molecular Function for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383453
genes like me logo Genes that share ontologies with SIRPG: view
genes like me logo Genes that share phenotypes with SIRPG: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIRPG Gene

Localization for SIRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRPG gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IDA 15383453
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIRPG: view

Pathways & Interactions for SIRPG Gene

genes like me logo Genes that share pathways with SIRPG: view

Pathways by source for SIRPG Gene

Gene Ontology (GO) - Biological Process for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007267 cell-cell signaling TAS 9062191
GO:0008284 positive regulation of cell proliferation IDA 15383453
GO:0008285 negative regulation of cell proliferation TAS 9062191
GO:0022409 positive regulation of cell-cell adhesion IDA 15383453
genes like me logo Genes that share ontologies with SIRPG: view

No data available for SIGNOR curated interactions for SIRPG Gene

Transcripts for SIRPG Gene

Unigene Clusters for SIRPG Gene

Signal-regulatory protein gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for SIRPG Gene

GeneLoc Exon Structure for
SIRPG
ECgene alternative splicing isoforms for
SIRPG

Expression for SIRPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPG Gene

This gene is overexpressed in Whole Blood (x17.2), Spleen (x10.2), and Small Intestine - Terminal Ileum (x7.5).

Protein differential expression in normal tissues from HIPED for SIRPG Gene

This gene is overexpressed in CD4 Tcells (40.4) and CD8 Tcells (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SIRPG Gene



Protein tissue co-expression partners for SIRPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SIRPG Gene:

SIRPG

SOURCE GeneReport for Unigene cluster for SIRPG Gene:

Hs.590883

mRNA Expression by UniProt/SwissProt for SIRPG Gene:

Q9P1W8-SIRPG_HUMAN
Tissue specificity: Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
genes like me logo Genes that share expression patterns with SIRPG: view

Primer Products

Orthologs for SIRPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPG 34 35
  • 98.19 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia SIRPB1 35
  • 62 (a)
ManyToMany
SIRPA 35
  • 49 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Sirpb1a 35
  • 55 (a)
ManyToMany
Sirpb1b 35
  • 55 (a)
ManyToMany
Sirpb1c 35
  • 55 (a)
ManyToMany
Gm9733 35
  • 46 (a)
ManyToMany
Sirpa 35
  • 41 (a)
ManyToMany
Gm5150 35
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
Species where no ortholog for SIRPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPG Gene

ENSEMBL:
Gene Tree for SIRPG (if available)
TreeFam:
Gene Tree for SIRPG (if available)

Paralogs for SIRPG Gene

Paralogs for SIRPG Gene

(9) SIMAP similar genes for SIRPG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIRPG: view

Variants for SIRPG Gene

Sequence variations from dbSNP and Humsavar for SIRPG Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10048858 -- 1,684,505(+) AATTA(C/T)GAAAC intron-variant
rs10211741 -- 1,659,373(+) CAGGG(G/T)GAAAT intron-variant, upstream-variant-2KB
rs10211807 -- 1,659,676(+) TCACC(C/T)GGCTT intron-variant, upstream-variant-2KB
rs1022641 -- 1,666,246(-) tactt(A/G)ttagt intron-variant
rs10439589 -- 1,676,782(+) ACAGG(C/T)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRPG Gene

Variant ID Type Subtype PubMed ID
esv2722071 CNV deletion 23290073
esv2722074 CNV deletion 23290073
esv2758777 CNV gain+loss 17122850
esv3644988 CNV gain 21293372
nsv428374 CNV loss 18775914
nsv510779 CNV deletion 20534489
nsv522008 CNV gain 19592680
nsv585206 CNV gain 21841781
nsv833894 CNV gain 17160897
nsv964369 CNV duplication 23825009

Variation tolerance for SIRPG Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPG Gene

Human Gene Mutation Database (HGMD)
SIRPG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPG Gene

Disorders for SIRPG Gene

Relevant External Links for SIRPG

Genetic Association Database (GAD)
SIRPG
Human Genome Epidemiology (HuGE) Navigator
SIRPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPG

No disorders were found for SIRPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPG Gene

Publications for SIRPG Gene

  1. Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. (PMID: 11185750) Ichigotani Y. … Hamaguchi M. (J. Hum. Genet. 2000) 2 3 4 22 64
  2. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. (PMID: 15383453) Piccio L. … Colonna M. (Blood 2005) 3 4 22 64
  3. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PMID: 19430480) Barrett J.C. … Rich S.S. (Nat. Genet. 2009) 3 46 64
  4. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. (PMID: 18524990) Stefanidakis M. … Luscinskas F.W. (Blood 2008) 3 22 64
  5. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3 64

Products for SIRPG Gene

Sources for SIRPG Gene

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