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Aliases for SIRPG Gene

Aliases for SIRPG Gene

  • Signal Regulatory Protein Gamma 2 3
  • CD172 Antigen-Like Family Member B 3 4
  • Signal-Regulatory Protein Beta 2 2 3
  • Signal-Regulatory Protein Beta-2 3 4
  • Signal-Regulatory Protein Gamma 2 5
  • CD172g Antigen 3 4
  • SIRP-Beta-2 3 4
  • SIRP-Gamma 3 4
  • SIRP-B2 3 4
  • SIRPB2 3 4
  • SIRP Beta 2 3
  • SIRPgamma 3
  • BA77C3.1 3
  • CD172g 3

External Ids for SIRPG Gene

Previous HGNC Symbols for SIRPG Gene

  • SIRPB2

Previous GeneCards Identifiers for SIRPG Gene

  • GC20M001558

Summaries for SIRPG Gene

Entrez Gene Summary for SIRPG Gene

  • The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRPG Gene

SIRPG (Signal Regulatory Protein Gamma) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Osteoclast differentiation. An important paralog of this gene is SIRPA.

UniProtKB/Swiss-Prot for SIRPG Gene

  • Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Gene Wiki entry for SIRPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPG Gene

Genomics for SIRPG Gene

Regulatory Elements for SIRPG Gene

Genomic Location for SIRPG Gene

Chromosome:
20
Start:
1,629,152 bp from pter
End:
1,686,516 bp from pter
Size:
57,365 bases
Orientation:
Minus strand

Genomic View for SIRPG Gene

Genes around SIRPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPG Gene

Proteins for SIRPG Gene

  • Protein details for SIRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1W8-SIRPG_HUMAN
    Recommended name:
    Signal-regulatory protein gamma
    Protein Accession:
    Q9P1W8
    Secondary Accessions:
    • B1AKP6
    • Q5D051
    • Q5JV25
    • Q5MKL4
    • Q8WWA5
    • Q9NQK8

    Protein attributes for SIRPG Gene

    Size:
    387 amino acids
    Molecular mass:
    42498 Da
    Quaternary structure:
    • Interacts with CD47.

    Three dimensional structures from OCA and Proteopedia for SIRPG Gene

    Alternative splice isoforms for SIRPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPG Gene

Proteomics data for SIRPG Gene at MOPED

Post-translational modifications for SIRPG Gene

  • Glycosylation at Asn 243, Asn 268, Asn 309, and Asn 317
  • Modification sites at PhosphoSitePlus

Other Protein References for SIRPG Gene

Antibody Products

  • R&D Systems Antibodies for SIRPG (SIRP gamma/CD172g)

No data available for DME Specific Peptides for SIRPG Gene

Domains & Families for SIRPG Gene

Protein Domains for SIRPG Gene

Suggested Antigen Peptide Sequences for SIRPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1W8

UniProtKB/Swiss-Prot:

SIRPG_HUMAN :
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPG: view

Function for SIRPG Gene

Molecular function for SIRPG Gene

UniProtKB/Swiss-Prot Function:
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
genes like me logo Genes that share phenotypes with SIRPG: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIRPG Gene

Localization for SIRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPG Gene COMPARTMENTS Subcellular localization image for SIRPG gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SIRPG Gene

Pathways & Interactions for SIRPG Gene

genes like me logo Genes that share pathways with SIRPG: view

Pathways by source for SIRPG Gene

Gene Ontology (GO) - Biological Process for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0035556 intracellular signal transduction TAS 9062191
GO:0050870 positive regulation of T cell activation IDA 15383453
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SIRPG: view

No data available for SIGNOR curated interactions for SIRPG Gene

Drugs & Compounds for SIRPG Gene

No Compound Related Data Available

Transcripts for SIRPG Gene

Unigene Clusters for SIRPG Gene

Signal-regulatory protein gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for SIRPG Gene

GeneLoc Exon Structure for
SIRPG
ECgene alternative splicing isoforms for
SIRPG

Expression for SIRPG Gene

mRNA expression in normal human tissues for SIRPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPG Gene

This gene is overexpressed in Whole Blood (x17.2), Spleen (x10.2), and Small Intestine - Terminal Ileum (x7.5).

Protein differential expression in normal tissues from HIPED for SIRPG Gene

This gene is overexpressed in CD4 Tcells (40.4) and CD8 Tcells (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIRPG Gene



SOURCE GeneReport for Unigene cluster for SIRPG Gene Hs.590883

mRNA Expression by UniProt/SwissProt for SIRPG Gene

Q9P1W8-SIRPG_HUMAN
Tissue specificity: Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
genes like me logo Genes that share expression patterns with SIRPG: view

Protein tissue co-expression partners for SIRPG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SIRPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPG 35
  • 98.19 (n)
  • 97.42 (a)
SIRPG 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
ManyToMany
SIRPA 36
  • 49 (a)
ManyToMany
SIRPB1 36
  • 62 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm5150 36
  • 27 (a)
ManyToMany
Gm9733 36
  • 46 (a)
ManyToMany
Sirpa 36
  • 41 (a)
ManyToMany
Sirpb1a 36
  • 55 (a)
ManyToMany
Sirpb1b 36
  • 55 (a)
ManyToMany
Sirpb1c 36
  • 55 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for SIRPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPG Gene

ENSEMBL:
Gene Tree for SIRPG (if available)
TreeFam:
Gene Tree for SIRPG (if available)

Paralogs for SIRPG Gene

Paralogs for SIRPG Gene

(9) SIMAP similar genes for SIRPG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIRPG: view

Variants for SIRPG Gene

Sequence variations from dbSNP and Humsavar for SIRPG Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_049936 -
VAR_049937 -
rs743080 -- 1,661,838(-) CTGGG(A/G)CAGTG intron-variant
rs743081 -- 1,661,011(+) GATGA(A/G)AATTA intron-variant
rs761824 -- 1,670,774(-) TCCTA(A/C)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRPG Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680
dgv1302e1 CNV Complex 17122850
nsv428374 CNV Loss 18775914
dgv4516n71 CNV Gain 21882294
nsv510779 CNV Loss 20534489
nsv833894 CNV Gain 17160897
esv2722071 CNV Deletion 23290073
esv2722074 CNV Deletion 23290073

Variation tolerance for SIRPG Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPG Gene

HapMap Linkage Disequilibrium report
SIRPG
Human Gene Mutation Database (HGMD)
SIRPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPG Gene

Disorders for SIRPG Gene

Relevant External Links for SIRPG

Genetic Association Database (GAD)
SIRPG
Human Genome Epidemiology (HuGE) Navigator
SIRPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRPG

No disorders were found for SIRPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPG Gene

Publications for SIRPG Gene

  1. Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. (PMID: 11185750) Ichigotani Y. … Hamaguchi M. (J. Hum. Genet. 2000) 2 3 4 23 67
  2. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. (PMID: 18524990) Stefanidakis M. … Luscinskas F.W. (Blood 2008) 3 23
  3. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3
  4. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. (PMID: 15383453) Piccio L. … Colonna M. (Blood 2005) 3 23
  5. Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. (PMID: 15294972) Brooke G. … Barclay A.N. (J. Immunol. 2004) 3 23

Products for SIRPG Gene

Sources for SIRPG Gene

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