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Aliases for SIRPG Gene

Aliases for SIRPG Gene

  • Signal-Regulatory Protein Gamma 2 3
  • SIRPB2 3 4 6
  • CD172 Antigen-Like Family Member B 3 4
  • Signal-Regulatory Protein Beta 2 2 3
  • Signal-Regulatory Protein Beta-2 3 4
  • CD172g Antigen 3 4
  • SIRP-Beta-2 3 4
  • SIRP-Gamma 3 4
  • SIRP-B2 3 4
  • SIRP Beta 2 3
  • SIRPgamma 3
  • BA77C3.1 3
  • CD172g 3

External Ids for SIRPG Gene

Previous HGNC Symbols for SIRPG Gene

  • SIRPB2

Previous GeneCards Identifiers for SIRPG Gene

  • GC20M001558

Summaries for SIRPG Gene

Entrez Gene Summary for SIRPG Gene

  • The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRPG Gene

SIRPG (Signal-Regulatory Protein Gamma) is a Protein Coding gene. Among its related pathways are Hemostasis and Cell junction organization. An important paralog of this gene is SIRPB1.

UniProtKB/Swiss-Prot for SIRPG Gene

  • Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Gene Wiki entry for SIRPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPG Gene

Genomics for SIRPG Gene

Regulatory Elements for SIRPG Gene

Genomic Location for SIRPG Gene

Start:
1,628,876 bp from pter
End:
1,657,779 bp from pter
Size:
28,904 bases
Orientation:
Minus strand

Genomic View for SIRPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPG Gene

Proteins for SIRPG Gene

  • Protein details for SIRPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1W8-SIRPG_HUMAN
    Recommended name:
    Signal-regulatory protein gamma
    Protein Accession:
    Q9P1W8
    Secondary Accessions:
    • B1AKP6
    • Q5D051
    • Q5JV25
    • Q5MKL4
    • Q8WWA5
    • Q9NQK8

    Protein attributes for SIRPG Gene

    Size:
    387 amino acids
    Molecular mass:
    42498 Da
    Quaternary structure:
    • Interacts with CD47.

    Three dimensional structures from OCA and Proteopedia for SIRPG Gene

    Alternative splice isoforms for SIRPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPG Gene

Proteomics data for SIRPG Gene at MOPED

Post-translational modifications for SIRPG Gene

  • Ubiquitination at Lys181
  • Glycosylation at Asn243, Asn268, Asn309, and Asn317
  • Modification sites at PhosphoSitePlus

Other Protein References for SIRPG Gene

Antibody Products

  • R&D Systems Antibodies for SIRPG (SIRP gamma/CD172g)

No data available for DME Specific Peptides for SIRPG Gene

Domains for SIRPG Gene

Gene Families for SIRPG Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • CD :CD molecules
  • SIRP :Signal-regulatory proteins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SIRPG Gene

Suggested Antigen Peptide Sequences for SIRPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1W8

UniProtKB/Swiss-Prot:

SIRPG_HUMAN :
  • Q9P1W8
Domain:
  • Contains 2 Ig-like C1-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPG: view

Function for SIRPG Gene

Molecular function for SIRPG Gene

UniProtKB/Swiss-Prot Function: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

Gene Ontology (GO) - Molecular Function for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383453
genes like me logo Genes that share ontologies with SIRPG: view

Phenotypes for SIRPG Gene

genes like me logo Genes that share phenotypes with SIRPG: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIRPG Gene

Localization for SIRPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPG Gene COMPARTMENTS Subcellular localization image for SIRPG gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 15383453
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIRPG: view

Pathways for SIRPG Gene

genes like me logo Genes that share pathways with SIRPG: view

Pathways by source for SIRPG Gene

Gene Ontology (GO) - Biological Process for SIRPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007267 cell-cell signaling TAS 9062191
GO:0007596 blood coagulation TAS --
GO:0008284 positive regulation of cell proliferation IDA 15383453
GO:0008285 negative regulation of cell proliferation TAS 9062191
genes like me logo Genes that share ontologies with SIRPG: view

Transcripts for SIRPG Gene

Unigene Clusters for SIRPG Gene

Signal-regulatory protein gamma:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIRPG

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for SIRPG Gene

GeneLoc Exon Structure for
SIRPG
ECgene alternative splicing isoforms for
SIRPG

Expression for SIRPG Gene

mRNA expression in normal human tissues for SIRPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPG Gene

This gene is overexpressed in Whole Blood (17.2), Spleen (10.2), and Small Intestine - Terminal Ileum (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIRPG Gene

SOURCE GeneReport for Unigene cluster for SIRPG Gene Hs.590883

mRNA Expression by UniProt/SwissProt for SIRPG Gene

Q9P1W8-SIRPG_HUMAN
Tissue specificity: Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.
genes like me logo Genes that share expressions with SIRPG: view

In Situ Assay Products

Orthologs for SIRPG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRPG 35
  • 98.19 (n)
  • 97.42 (a)
SIRPG 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 41 (a)
ManyToMany
SIRPA 36
  • 49 (a)
ManyToMany
SIRPB1 36
  • 62 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm5150 36
  • 27 (a)
ManyToMany
Gm9733 36
  • 46 (a)
ManyToMany
Sirpa 36
  • 41 (a)
ManyToMany
Sirpb1a 36
  • 55 (a)
ManyToMany
Sirpb1b 36
  • 55 (a)
ManyToMany
Sirpb1c 36
  • 55 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for SIRPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPG Gene

ENSEMBL:
Gene Tree for SIRPG (if available)
TreeFam:
Gene Tree for SIRPG (if available)

Paralogs for SIRPG Gene

Paralogs for SIRPG Gene

Selected SIMAP similar genes for SIRPG Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SIRPG: view

Variants for SIRPG Gene

Sequence variations from dbSNP and Humsavar for SIRPG Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs963168 -- 1,657,932(-) GTCTG(A/G)TTATC upstream-variant-2KB
rs1048055 -- 1,629,416(-) GCAGG(G/T)GCCAT utr-variant-3-prime
rs2209311 -- 1,628,610(+) AAATC(A/C)CTGTA downstream-variant-500B
rs2209312 -- 1,628,731(+) CTCAG(C/T)GCTCT downstream-variant-500B
rs2256335 -- 1,655,857(+) GAGAA(A/C)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRPG Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680
dgv1302e1 CNV Complex 17122850
nsv428374 CNV Loss 18775914
dgv4516n71 CNV Gain 21882294
nsv510779 CNV Loss 20534489
nsv833894 CNV Gain 17160897
esv2722071 CNV Deletion 23290073
esv2722074 CNV Deletion 23290073

Relevant External Links for SIRPG Gene

HapMap Linkage Disequilibrium report
SIRPG
Human Gene Mutation Database (HGMD)
SIRPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPG Gene

Disorders for SIRPG Gene

Relevant External Links for SIRPG

Genetic Association Database (GAD)
SIRPG
Human Genome Epidemiology (HuGE) Navigator
SIRPG
genes like me logo Genes that share disorders with SIRPG: view

No data available for UniProtKB/Swiss-Prot for SIRPG Gene

Publications for SIRPG Gene

  1. Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family. (PMID: 11185750) Ichigotani Y. … Hamaguchi M. (J. Hum. Genet. 2000) 2 3 4 23
  2. Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation. (PMID: 15383453) Piccio L. … Colonna M. (Blood 2005) 3 4 23
  3. Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. (PMID: 15294972) Brooke G. … Barclay A.N. (J. Immunol. 2004) 3 23
  4. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. (PMID: 18524990) Stefanidakis M. … Luscinskas F.W. (Blood 2008) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for SIRPG Gene

Sources for SIRPG Gene

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