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Aliases for SIRPD Gene

Aliases for SIRPD Gene

  • Signal Regulatory Protein Delta 2 3 5
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 2 2 3
  • Signal-Regulatory Protein Delta 2 3
  • SIRP-Delta 3 4
  • PTPNS1L2 3 4
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 2 4
  • DJ576H24.4 3

External Ids for SIRPD Gene

Previous HGNC Symbols for SIRPD Gene

  • PTPNS1L2

Previous GeneCards Identifiers for SIRPD Gene

  • GC20M001463
  • GC20M001514
  • GC20M001465

Summaries for SIRPD Gene

GeneCards Summary for SIRPD Gene

SIRPD (Signal Regulatory Protein Delta) is a Protein Coding gene. An important paralog of this gene is SIRPG.

Additional gene information for SIRPD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPD Gene

Genomics for SIRPD Gene

Regulatory Elements for SIRPD Gene

Enhancers for SIRPD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H001622 1.3 Ensembl ENCODE dbSUPER 11.2 -64.3 -64303 2 HDGF EBF1 FOXK2 EED ATF7 ETV6 RUNX3 IKZF2 ZNF687 CBFB SIRPB1 SIRPG ENSG00000271523 SIRPD ENSG00000242324 ENSG00000260861
GH20H001535 1.1 Ensembl ENCODE 11.9 +22.2 22214 3 HDGF CTCF TBL1XR1 MAX BATF RELA POLR2A EED ZNF143 SMC3 SIRPD ENSG00000242324 NSFL1C SIRPB1 ENSG00000271523 RNU6-917P
GH20H001286 0.9 FANTOM5 ENCODE dbSUPER 10.2 +272.0 272019 0 ZIC2 SNPH RAD21L1 SDCBP2 FKBP1A ENSG00000242324 SIRPD SIRPG PIR62557 ENSG00000280162
GH20H001731 0.9 Ensembl ENCODE 10 -173.1 -173077 0 HDGF ZBED1 NR2F1 JUNB BATF EED IKZF1 TARDBP NBN ETV6 SIRPG ENSG00000242324 SIRPD SIRPB1 LOC105369219 PIR35224
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRPD on UCSC Golden Path with GeneCards custom track

Genomic Location for SIRPD Gene

1,534,223 bp from pter
1,559,006 bp from pter
24,784 bases
Minus strand

Genomic View for SIRPD Gene

Genes around SIRPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPD Gene

Proteins for SIRPD Gene

  • Protein details for SIRPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-regulatory protein delta
    Protein Accession:
    Secondary Accessions:
    • B3KS88
    • Q5TFQ6

    Protein attributes for SIRPD Gene

    197 amino acids
    Molecular mass:
    21687 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIRPD Gene

Post-translational modifications for SIRPD Gene

  • Glycosylation at Asn174
  • Modification sites at PhosphoSitePlus

Other Protein References for SIRPD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIRPD Gene

Domains & Families for SIRPD Gene

Gene Families for SIRPD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SIRPD Gene

Suggested Antigen Peptide Sequences for SIRPD Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SIRPD: view

No data available for UniProtKB/Swiss-Prot for SIRPD Gene

Function for SIRPD Gene

Phenotypes From GWAS Catalog for SIRPD Gene

genes like me logo Genes that share phenotypes with SIRPD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SIRPD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIRPD Gene

Localization for SIRPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPD Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRPD gene
Compartment Confidence
extracellular 4
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SIRPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SIRPD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIRPD Gene

Pathways & Interactions for SIRPD Gene

SuperPathways for SIRPD Gene

No Data Available

Interacting Proteins for SIRPD Gene

Gene Ontology (GO) - Biological Process for SIRPD Gene


No data available for Pathways by source and SIGNOR curated interactions for SIRPD Gene

Drugs & Compounds for SIRPD Gene

No Compound Related Data Available

Transcripts for SIRPD Gene

mRNA/cDNA for SIRPD Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIRPD Gene

Signal-regulatory protein delta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SIRPD
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -

Relevant External Links for SIRPD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIRPD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPD Gene

This gene is overexpressed in Testis (x39.3) and Whole Blood (x9.4).

NURSA nuclear receptor signaling pathways regulating expression of SIRPD Gene:


SOURCE GeneReport for Unigene cluster for SIRPD Gene:


Evidence on tissue expression from TISSUES for SIRPD Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SIRPD: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRPD Gene

Orthologs for SIRPD Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIRPD 33
  • 98.02 (n)
-- 34
  • 95 (a)
-- 34
  • 4 (a)
(Bos Taurus)
Mammalia SIRPD 34
  • 34 (a)
(Canis familiaris)
Mammalia SIRPD 34
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
Species where no ortholog for SIRPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPD Gene

Gene Tree for SIRPD (if available)
Gene Tree for SIRPD (if available)

Paralogs for SIRPD Gene

Paralogs for SIRPD Gene

(4) SIMAP similar genes for SIRPD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIRPD: view

Variants for SIRPD Gene

Sequence variations from dbSNP and Humsavar for SIRPD Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000095936 -- 1,545,681(+) TTCTT(C/T)GGAGG intron-variant
rs1000194893 -- 1,539,936(+) TGCAG(C/T)CTTAA intron-variant, nc-transcript-variant
rs1000203788 -- 1,550,109(+) CTACC(G/T)GGGTT intron-variant, nc-transcript-variant
rs1000220917 -- 1,540,198(+) GGATG(A/C)TGGCA intron-variant
rs1000376837 -- 1,544,496(+) TATTT(G/T)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRPD Gene

Variant ID Type Subtype PubMed ID
esv2758777 CNV gain+loss 17122850
esv3644980 CNV gain 21293372
nsv428374 CNV loss 18775914
nsv510779 CNV deletion 20534489
nsv522008 CNV gain 19592680
nsv585206 CNV gain 21841781
nsv833893 CNV loss 17160897
nsv833894 CNV gain 17160897
nsv9775 CNV loss 18304495

Variation tolerance for SIRPD Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPD Gene

Disorders for SIRPD Gene

Relevant External Links for SIRPD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIRPD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPD Gene

Publications for SIRPD Gene

  1. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg TK … Barclay AN (Journal of immunology (Baltimore, Md. : 1950) 2005) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SIRPD Gene

Sources for SIRPD Gene

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