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Aliases for SIRPD Gene

Aliases for SIRPD Gene

  • Signal Regulatory Protein Delta 2 3 5
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 2 2 3
  • Signal-Regulatory Protein Delta 2 3
  • SIRP-Delta 3 4
  • PTPNS1L2 3 4
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 2 4
  • DJ576H24.4 3

External Ids for SIRPD Gene

Previous HGNC Symbols for SIRPD Gene

  • PTPNS1L2

Previous GeneCards Identifiers for SIRPD Gene

  • GC20M001463
  • GC20M001514
  • GC20M001465

Summaries for SIRPD Gene

GeneCards Summary for SIRPD Gene

SIRPD (Signal Regulatory Protein Delta) is a Protein Coding gene. An important paralog of this gene is SIRPG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPD Gene

Genomics for SIRPD Gene

Regulatory Elements for SIRPD Gene

Enhancers for SIRPD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F001535 1.2 Ensembl ENCODE 11.9 +21.9 21936 3.9 HDGF CTCF TBL1XR1 MAX RELA CBX5 EED ZNF143 ETV6 NFE2 SIRPB1 NSFL1C SIRPD ENSG00000242324 ENSG00000271523 RNU6-917P
GH20F001626 0.2 Ensembl 11.2 -68.1 -68095 1.4 IKZF1 EED ETV6 MNT EBF1 CREM SPI1 ENSG00000271523 SIRPG ENSG00000242324 SIRPD SIRPB1 SIRPG-AS1
GH20F001633 0.2 Ensembl 11.1 -74.7 -74695 0.2 SOX13 HLF NR2F1 CEBPB ZEB2 ZNF644 RARA IKZF1 HMBOX1 NR2F6 SIRPG SIRPD ENSG00000242324 SIRPG-AS1 RN7SL561P
GH20F001631 0.6 Ensembl 11.1 -72.8 -72795 0.8 CEBPB JUNB JUND ZNF316 IKZF1 ETV6 MAFK EMSY PRDM1 SIRPG ENSG00000242324 SIRPD SIRPG-AS1 SIRPB1
GH20F001632 0.5 Ensembl 11.1 -73.5 -73495 0.2 JUND HLF IKZF1 EED JUNB ETV6 EBF1 SIRPG ENSG00000242324 SIRPD SIRPG-AS1 SIRPB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SIRPD on UCSC Golden Path with GeneCards custom track

Genomic Location for SIRPD Gene

1,534,223 bp from pter
1,559,006 bp from pter
24,784 bases
Minus strand

Genomic View for SIRPD Gene

Genes around SIRPD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPD Gene

Proteins for SIRPD Gene

  • Protein details for SIRPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-regulatory protein delta
    Protein Accession:
    Secondary Accessions:
    • B3KS88
    • Q5TFQ6

    Protein attributes for SIRPD Gene

    197 amino acids
    Molecular mass:
    21687 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIRPD Gene

Post-translational modifications for SIRPD Gene

  • Glycosylation at Asn 174
  • Modification sites at PhosphoSitePlus

Other Protein References for SIRPD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIRPD Gene

Domains & Families for SIRPD Gene

Protein Domains for SIRPD Gene

Suggested Antigen Peptide Sequences for SIRPD Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPD: view

Function for SIRPD Gene

genes like me logo Genes that share phenotypes with SIRPD: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SIRPD Gene

Localization for SIRPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPD Gene


Subcellular locations from

Jensen Localization Image for SIRPD Gene COMPARTMENTS Subcellular localization image for SIRPD gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIRPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SIRPD: view

Pathways & Interactions for SIRPD Gene

SuperPathways for SIRPD Gene

No Data Available

Interacting Proteins for SIRPD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000371036 Q9H106-SIRPD_HUMAN for SIRPD Gene via STRING IID

Gene Ontology (GO) - Biological Process for SIRPD Gene


No data available for Pathways by source and SIGNOR curated interactions for SIRPD Gene

Transcripts for SIRPD Gene

mRNA/cDNA for SIRPD Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SIRPD Gene

Signal-regulatory protein delta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -

Relevant External Links for SIRPD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIRPD Gene

mRNA expression in normal human tissues for SIRPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPD Gene

This gene is overexpressed in Testis (x39.3) and Whole Blood (x9.4).

NURSA nuclear receptor signaling pathways regulating expression of SIRPD Gene:


SOURCE GeneReport for Unigene cluster for SIRPD Gene:

genes like me logo Genes that share expression patterns with SIRPD: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SIRPD Gene

Orthologs for SIRPD Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIRPD 34
  • 98.02 (n)
-- 35
  • 95 (a)
-- 35
  • 4 (a)
(Bos Taurus)
Mammalia SIRPD 35
  • 34 (a)
(Canis familiaris)
Mammalia SIRPD 35
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
Species where no ortholog for SIRPD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPD Gene

Gene Tree for SIRPD (if available)
Gene Tree for SIRPD (if available)

Paralogs for SIRPD Gene

Paralogs for SIRPD Gene

(4) SIMAP similar genes for SIRPD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIRPD: view

Variants for SIRPD Gene

Sequence variations from dbSNP and Humsavar for SIRPD Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10485824 -- 1,537,454(+) TATAA(A/G)GGTCC intron-variant
rs111341580 -- 1,549,448(+) AACTG(A/G)ACATC intron-variant
rs111371691 -- 1,554,097(+) GTTTT(C/T)CACTG intron-variant
rs111431969 -- 1,551,800(+) TCACG(C/G)ATGCG downstream-variant-500B, reference, missense
rs111578991 -- 1,559,275(+) CTCCC(A/G)AGTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SIRPD Gene

Variant ID Type Subtype PubMed ID
esv2758777 CNV gain+loss 17122850
esv3644980 CNV gain 21293372
nsv428374 CNV loss 18775914
nsv510779 CNV deletion 20534489
nsv522008 CNV gain 19592680
nsv585206 CNV gain 21841781
nsv833893 CNV loss 17160897
nsv833894 CNV gain 17160897
nsv9775 CNV loss 18304495

Variation tolerance for SIRPD Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRPD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPD Gene

Disorders for SIRPD Gene

Relevant External Links for SIRPD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SIRPD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPD Gene

Publications for SIRPD Gene

  1. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3 64

Products for SIRPD Gene

Sources for SIRPD Gene

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