SIRPD Gene
protein-coding GIFtS: 44
GCID: GC20M001514
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signal-regulatory protein delta(Previous names: protein tyrosine phosphatase, non-receptor type substrate...)
(Previous symbol: PTPNS1L2)
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Aliases
for SIRPD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Signal-Regulatory Protein Delta1 2 | | PTPNS1L21 2 3 | | DJ576H24.41 | | Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 21 2 | | Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 22 3 | | SIRP-Delta1 |
Export aliases for SIRPD gene to outside databasesPrevious GC identifers: GC20M001463 GC20M001465 |
Summaries
for SIRPD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SIRPD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SIRPD gene promoter:
GCNF HTF XBP-1 Max GCNF-1 GCNF-2 c-Myc ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for SIRPD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13SIRPD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M001514: view genomic region
(about GC identifiers)
Start:
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1,514,897 bp from pter |
End:
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1,539,489 bp from pter |
Size:
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24,593 bases |
Orientation:
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minus strand |
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Proteins
for SIRPD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SIRPD_HUMAN, Q9H106 (See
protein sequence)Recommended Name: Signal-regulatory protein delta precursor Size: 197 amino acids; 21687 Da
Subcellular location: Secreted (Potential)
Secondary accessions: B3KS88 Q5TFQ6Explore the universe of human proteins at neXtProt for SIRPD: NX_Q9H106
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H106
SIRPD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848555.2
ENSEMBL proteins: ENSP00000410072 ENSP00000371034 ENSP00000371036
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
SIRPD for ontologies About GeneDecksing
SIRPD Antibody Products:
Assay Products for SIRPD: |
Protein
Domains /
Families
for SIRPD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SIRPD for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H106ProtoNet protein and cluster: Q9H106 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: SIRPD_HUMAN, Q9H106Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for SIRPD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPD
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SIRPD (NM_178460) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRPD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPD |
1 GenomeRNAi human phenotype for SIRPD:
|
Pathways & Interactions
for SIRPD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SIRPD
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SIRPD (ENSP000003710364) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SIRPD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SIRPD
Search CenterWatch for drugs/clinical trials and news about SIRPD
|
Transcripts
for SIRPD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SIRPD gene: NM_178460.2 Unigene Cluster for SIRPD: Signal-regulatory protein delta Hs.729560 [show with all ESTs]Unigene Representative Sequence: NM_1784603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000429387 ENST00000381621 ENST00000381623(uc002wfi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPD
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SIRPD (NM_178460) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SIRPD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPD |
Additional cDNA sequence: BC033502.1 4 DOTS entries: DT.97812322 DT.102893 DT.443439 DT.120838642 24/67 AceView cDNA sequences (see all 67): BQ635330 BQ635331 CD369292 AL597487 CA748838 AK130124 BM285386 BI756472 BQ635329 AA709221 T78888 BQ635328 AI219993 AI939310 CD368713 BI910932 BM998154 BI830800 BX089051 CA306410 BI908893 BC025286 AA315922 BI823904
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SIRPD About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
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| SP1: | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SIRPD
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Expression
for SIRPD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SIRPD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCCCATAC
About this image
See SIRPD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SIRPD
SOURCE GeneReport for Unigene cluster: Hs.729560
SABiosciences Custom PCR Arrays for SIRPD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRPD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SIRPD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRPD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRPD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPD |
Orthologs
for SIRPD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SIRPD gene from 2/4 species (see all 4) About this table
ENSEMBL Gene Tree for SIRPD (if available)
TreeFam Gene Tree for SIRPD (if available) |
Paralogs
for SIRPD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SIRPD gene
- SIRPB22 SIRPB12 ENSG000002608612 SIRPA2 SIRPG2
4 SIMAP similar genes for SIRPD using alignment to 3 protein entries: SIRPD_HUMAN (see all proteins):SIRPB1 SIRPG PTPNS1 SIRPB2
SIRPD for paralogs About GeneDecksing
|
Genomic Variants
for SIRPD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SIRPD (1514897 - 1539489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SIRPD
2 CNVs: 4090 32404 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRPD |
|
Disorders
/ Diseases
for SIRPD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 SIRPD for disorders About MalaCards
SIRPD for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SIRPD (1 document)
Export disorders for SIRPD gene to outside databases
|
Publications
for SIRPD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SIRPD gene integrated from 9 sources:
(articles sorted by number of sources associating them with SIRPD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A nomenclature for signal regulatory protein family m embers. (PubMed id 16339511)1, 3 van den Berg T.K....Barclay A.N. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SIRPD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SIRPD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SIRPD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SIRPD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SIRPD | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SIRPD gene:
Search GeneIP for patents involving SIRPD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SIRPD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SIRPD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SIRPD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SIRPD | | | OriGene Protein Over-expression Lysate for SIRPD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SIRPD | | OriGene 3'-UTR Clone for SIRPD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SIRPD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SIRPD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SIRPD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SIRPD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SIRPD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SIRPD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SIRPD |
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 |  |  |  | |
| | | | Search Tocris compounds for SIRPD |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SIRPD |
|  |  |  | | | | Search ThermoFisher Antibodies for SIRPD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SIRPD |
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