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Aliases for SIRPD Gene

Aliases for SIRPD Gene

  • Signal-Regulatory Protein Delta 2 3
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 2 2 3
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 2 3 4
  • SIRP-Delta 3 4
  • PTPNS1L2 3 4
  • DJ576H24.4 3

External Ids for SIRPD Gene

Previous HGNC Symbols for SIRPD Gene

  • PTPNS1L2

Previous GeneCards Identifiers for SIRPD Gene

  • GC20M001463
  • GC20M001514
  • GC20M001465

Summaries for SIRPD Gene

GeneCards Summary for SIRPD Gene

SIRPD (Signal-Regulatory Protein Delta) is a Protein Coding gene. An important paralog of this gene is SIRPB1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRPD Gene

Genomics for SIRPD Gene

Regulatory Elements for SIRPD Gene

Genomic Location for SIRPD Gene

Start:
1,534,251 bp from pter
End:
1,558,979 bp from pter
Size:
24,729 bases
Orientation:
Minus strand

Genomic View for SIRPD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPD Gene

Proteins for SIRPD Gene

  • Protein details for SIRPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H106-SIRPD_HUMAN
    Recommended name:
    Signal-regulatory protein delta
    Protein Accession:
    Q9H106
    Secondary Accessions:
    • B3KS88
    • Q5TFQ6

    Protein attributes for SIRPD Gene

    Size:
    197 amino acids
    Molecular mass:
    21687 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SIRPD Gene

Proteomics data for SIRPD Gene at MOPED

Post-translational modifications for SIRPD Gene

  • Glycosylation at Asn174
  • Modification sites at PhosphoSitePlus

Other Protein References for SIRPD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SIRPD Gene

Domains for SIRPD Gene

Gene Families for SIRPD Gene

HGNC:
  • SIRP :Signal-regulatory proteins
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for SIRPD Gene

Suggested Antigen Peptide Sequences for SIRPD Gene

Graphical View of Domain Structure for InterPro Entry

Q9H106

UniProtKB/Swiss-Prot:

SIRPD_HUMAN :
  • Q9H106
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with SIRPD: view

Function for SIRPD Gene

Gene Ontology (GO) - Molecular Function for SIRPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SIRPD: view

Phenotypes for SIRPD Gene

GenomeRNAi human phenotypes for SIRPD:
genes like me logo Genes that share phenotypes with SIRPD: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SIRPD Gene

Localization for SIRPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPD Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRPD Gene COMPARTMENTS Subcellular localization image for SIRPD gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SIRPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SIRPD: view

Pathways for SIRPD Gene

SuperPathways for SIRPD Gene

No Data Available

Interacting Proteins for SIRPD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000371036%0d%0a9606.ENSP00000276603%0d%0a
Selected Interacting proteins: ENSP00000371036 for SIRPD Gene via STRING

Symbol External ID(s) Details
TERF1

Gene Ontology (GO) - Biological Process for SIRPD Gene

None

No data available for Pathways by source for SIRPD Gene

Transcripts for SIRPD Gene

mRNA/cDNA for SIRPD Gene

Unigene Clusters for SIRPD Gene

Signal-regulatory protein delta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SIRPD

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: -
SP3: -
SP4:

Relevant External Links for SIRPD Gene

GeneLoc Exon Structure for
SIRPD
ECgene alternative splicing isoforms for
SIRPD

Expression for SIRPD Gene

mRNA expression in normal human tissues for SIRPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPD Gene

This gene is overexpressed in Testis (39.3) and Whole Blood (9.4).

SOURCE GeneReport for Unigene cluster for SIRPD Gene Hs.729560

genes like me logo Genes that share expressions with SIRPD: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for SIRPD Gene

Orthologs for SIRPD Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 4 (a)
OneToMany
SIRPD 35
  • 98.02 (n)
  • 95.68 (a)
cow
(Bos Taurus)
Mammalia SIRPD 36
  • 34 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIRPD 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
Species with no ortholog for SIRPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIRPD Gene

ENSEMBL:
Gene Tree for SIRPD (if available)
TreeFam:
Gene Tree for SIRPD (if available)

Paralogs for SIRPD Gene

Paralogs for SIRPD Gene

Selected SIMAP similar genes for SIRPD Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIRPD: view

Variants for SIRPD Gene

Sequence variations from dbSNP and Humsavar for SIRPD Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2246154 -- 1,547,392(+) gattg(A/C)tgtgg intron-variant
rs2249317 - 1,551,949(+) GGTAT(C/T)GGGTA reference, missense
rs2249431 -- 1,552,559(+) GCATA(C/T)GGTTC intron-variant
rs2249549 -- 1,553,606(+) CTAGG(A/G)CCCAG intron-variant
rs2249673 -- 1,554,384(+) TCTCA(A/G)TATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRPD Gene

Variant ID Type Subtype PubMed ID
nsv522008 CNV Gain 19592680
nsv833893 CNV Loss 17160897
dgv1301e1 CNV Complex 17122850
dgv1302e1 CNV Complex 17122850
nsv428374 CNV Loss 18775914
dgv4516n71 CNV Gain 21882294
nsv510779 CNV Loss 20534489
nsv833894 CNV Gain 17160897
nsv9775 CNV Loss 18304495

Relevant External Links for SIRPD Gene

HapMap Linkage Disequilibrium report
SIRPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPD Gene

Disorders for SIRPD Gene

Relevant External Links for SIRPD

Genetic Association Database (GAD)
SIRPD
Human Genome Epidemiology (HuGE) Navigator
SIRPD
genes like me logo Genes that share disorders with SIRPD: view

No data available for UniProtKB/Swiss-Prot for SIRPD Gene

Publications for SIRPD Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg T.K. … Barclay A.N. (J. Immunol. 2005) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SIRPD Gene

Sources for SIRPD Gene

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